LiteFold/InterPro · Datasets at Hugging Face

IPR018708

18,708

Protein of unknown function DUF2225

DUF2225

Family

1,853

false

This conserved bacterial family has no known function.

[]

0

[ "PFAM" ]

[ "PF09986" ]

[ "DUF2225" ]

[ 1853 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 1788, 36, 6, 23 ]

4

[]

0

true

Family

Protein of unknown function DUF2225

DUF2225

1

IPR018709

18,709

CoA enzyme activase, domain of unknown function DUF2229

CoA_activase_DUF2229

Domain

5,015

false

Proteins containing this domain include various bacterial hypothetical proteins, as well as CoA enzyme activases. The exact function of this domain has not, as yet, been defined.

[]

0

[ "PFAM" ]

[ "PF09989" ]

[ "DUF2229" ]

[ 5015 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Metamonada", "metagenomes" ]

[ 19, 4767, 28, 201 ]

4

[]

0

true

Domain

CoA enzyme activase, domain of unknown function DUF2229

CoA_activase_DUF2229

2

IPR018711

18,711

Phosphodiester glycosidase

NAGPA

Domain

15,237

false

This domain can be found in many bacterial and several viral proteins and can be identified in the mammalian transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA). Some proteins containing this domain may function as phosphodiester glycosidases [ ].

[]

0

[ "PFAM" ]

[ "PF09992" ]

[ "NAGPA" ]

[ 15237 ]

1

[]

0

[ "3ohg", "5h3k", "6ozd", "6pkg", "6pkh", "6pki", "6pku", "6pky", "6u11" ]

9

[ "PUB00078675" ]

[ "23572527" ]

[ "Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme." ]

[ 2013 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4, 13624, 1389, 43, 177 ]

5

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 4, 5, 5 ]

5

true

Domain

Phosphodiester glycosidase

NAGPA

8

IPR018712

18,712

T6SS, Phospholipase effector Tle1-like, catalytic domain

Tle1-like_cat

Domain

15,987

false

This entry represents a domain found in the type VI secretion system (T6SS) Phospholipase effector Tle1 from Pseudomonas aeruginosa ( ) and similar bacterial and fungal sequences. Tle1, which hydrolyse membrane phospholipids, is organised into two distinct parts, the phospholipase catalytic module (this entry) and the ...

[]

0

[ "PFAM" ]

[ "PF09994" ]

[ "T6SS_Tle1-like_cat" ]

[ 15987 ]

1

[]

0

[ "4o5p", "6sjl", "6ski", "9j3f" ]

4

[ "PUB00100135", "PUB00154252" ]

[ "32350888", "25084336" ]

[ "Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike.", "Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting." ]

[ 2020, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6829, 9125, 33 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1 ]

2

true

Domain

T6SS, Phospholipase effector Tle1-like, catalytic domain

Tle1-like_cat

2

IPR018713

18,713

ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase, catalytic domain

MPAB/Lcp_cat_dom

Domain

22,077

false

This entry represents the catalytic domain found in the endoplasmic reticulum (ER)-bound oxygenases mpaB' (MPAB2) and mpaB (MPAB) from Penicillium brevicompactum and Penicillium roqueforti and in the rubber oxygenase (Lcp) from Streptomyces sp., which contains highly conserved arginine and histidine residues. Structura...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09995" ]

[ "MPAB_Lcp_cat" ]

[ 22077 ]

1

[]

0

[ "5o1l", "5o1m" ]

2

[ "PUB00087009", "PUB00096709", "PUB00096710" ]

[ "28733658", "31209052", "25819959" ]

[ "Structural and Functional Analysis of Latex Clearing Protein (Lcp) Provides Insight into the Enzymatic Cleavage of Rubber.", "Compartmentalized biosynthesis of mycophenolic acid.", "Latex Clearing Protein (Lcp) of Streptomyces sp. Strain K30 Is a b-Type Cytochrome and Differs from Rubber Oxygenase A (RoxA) in ...

[ 2017, 2019, 2015 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 18642, 3213, 2, 220 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase, catalytic domain

MPAB/Lcp_cat_dom

7

IPR018714

18,714

Protein of unknown function DUF2237

DUF2237

Family

4,349

false

This family of hypothetical proteins has no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09996", "PTHR37466" ]

[ "DUF2237", "" ]

[ 4349, 4251 ]

2

[]

0

[ "2lq3", "3ush", "4ioh" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Mimiviridae sp. ChoanoV1", "unclassified sequences" ]

[ 3188, 846, 185, 1, 129 ]

5

[]

0

true

Family

Protein of unknown function DUF2237

DUF2237

9

IPR018715

18,715

Protein of unknown function DUF2239

DUF2239

Family

1,836

false

This family of uncharacterised bacterial proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09998" ]

[ "DUF2239" ]

[ 1836 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Dikarya", "metagenomes" ]

[ 1827, 2, 7 ]

3

[]

0

true

Family

Protein of unknown function DUF2239

DUF2239

3

IPR018716

18,716

Protein of unknown function DUF2240

DUF2240

Family

579

false

This family of various hypothetical archaeal proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF09999" ]

[ "DUF2240" ]

[ 579 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 557, 22 ]

2

[]

0

true

Family

Protein of unknown function DUF2240

DUF2240

3

IPR018718

18,718

Protein of unknown function DUF2242

DUF2242

Family

1,607

false

This family includes putative lipoproteins and uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF10001" ]

[ "DUF2242" ]

[ 1607 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1601, 4, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF2242

DUF2242

8

IPR018719

18,719

Protein of unknown function DUF2243, membrane

DUF2243_membrane

Family

2,577

false

This entry includes membrane proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF10002" ]

[ "DUF2243" ]

[ 2577 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 118, 2457, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF2243, membrane

DUF2243_membrane

7

IPR018720

18,720

Domain of unknown function DUF2249

DUF2249

Domain

5,060

false

This domain is found in a number of hypothetical bacterial and archaeal proteins with no known function. It is also found in proteins described as cupin 2 and hemerythrin. It represents a conserved region that shows distant similarity to the SirA protein (see ).

[]

0

[ "PFAM" ]

[ "PF10006" ]

[ "DUF2249" ]

[ 5060 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 868, 4092, 100 ]

3

[]

0

true

Domain

Domain of unknown function DUF2249

DUF2249

9

IPR018721

18,721

Protein of unknown function DUF2252

DUF2252

Family

8,993

false

DUF2252 has no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10009", "PTHR39441" ]

[ "DUF2252", "" ]

[ 8993, 8813 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 8620, 292, 4, 77 ]

4

[]

0

true

Family

Protein of unknown function DUF2252

DUF2252

2

IPR018723

18,723

Protein of unknown function DUF2254, membrane

DUF2254_membrane

Family

6,312

false

Members of this family of proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.

[]

0

[ "PFAM" ]

[ "PF10011" ]

[ "DUF2254" ]

[ 6312 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 110, 6120, 50, 32 ]

4

[]

0

true

Family

Protein of unknown function DUF2254, membrane

DUF2254_membrane

7

IPR018724

18,724

2OG-Fe dioxygenase

2OG-Fe_dioxygenase

Family

3,788

false

This family contains Fe-dependent dioxygenases, including L-isoleucine dioxygenase (IDO) [ ], 3(1)-hydroxy-L-isoleucine 4-dioxygenase (HilB) [ ] and Bifunctional enzyme flvA [ ].

[ "GO:0051213" ]

[ "dioxygenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10014" ]

[ "2OG-Fe_Oxy_2" ]

[ 3788 ]

1

[]

0

[ "3pl0", "6lnh", "7eeh", "8jms", "8w8h", "9dq0", "9dq1", "9dq2", "9dqp", "9dqq", "9dqr" ]

11

[ "PUB00066716", "PUB00100359", "PUB00100360" ]

[ "19850012", "31885262", "23554367" ]

[ "A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine.", "Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway.", "A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydr...

[ 2009, 2020, 2013 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3443, 326, 19 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

2OG-Fe dioxygenase

2OG-Fe_dioxygenase

4

IPR018725

18,725

Protein of unknown function DUF2259, secreted

DUF2259_secreted

Family

660

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10016" ]

[ "DUF2259" ]

[ 660 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 654, 6 ]

2

[]

0

true

Family

Protein of unknown function DUF2259, secreted

DUF2259_secreted

6

IPR018728

18,728

Domain of unknown function DUF2268

DUF2268

Domain

3,091

false

This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.

[]

0

[ "PFAM" ]

[ "PF10026" ]

[ "DUF2268" ]

[ 3091 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Fungi", "ecological metagenomes" ]

[ 8, 3069, 6, 8 ]

4

[]

0

true

Domain

Domain of unknown function DUF2268

DUF2268

2

IPR018729

18,729

Protein of unknown function DUF2269, transmembrane

DUF2269_transmembrane

Family

4,466

false

Members of this family of bacterial hypothetical integral membrane proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10027" ]

[ "DUF2269" ]

[ 4466 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "Protostomia", "metagenomes" ]

[ 4426, 4, 2, 34 ]

4

[]

0

true

Family

Protein of unknown function DUF2269, transmembrane

DUF2269_transmembrane

8

IPR018730

18,730

Protein of unknown function DUF2273

DUF2273

Family

2,187

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10031" ]

[ "DUF2273" ]

[ 2187 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2168, 19 ]

2

[]

0

true

Family

Protein of unknown function DUF2273

DUF2273

6

IPR018731

18,731

Autophagy-related protein 13, N-terminal

Atg13_N

Domain

6,139

false

This entry represents the N-terminal domain of autophagy-related protein 13 (Atg13) from yeasts, animals and plants. They function in autophagy. Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex o...

[ "GO:0006914", "GO:1990316" ]

[ "autophagy", "Atg1/ULK1 kinase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF10033" ]

[ "ATG13" ]

[ 6139 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-1632852", "R-DRE-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-SCE-1632852", "R-SPO-1632852", "R-XTR-1632852" ]

[ "REACTOME:R-DME-1632852", "REACTOME:R-DRE-1632852", "REACTOME:R-HSA-1632852", "REACTOME:R-MMU-1632852", "REACTOME:R-SCE-1632852", "REACTOME:R-SPO-1632852", "REACTOME:R-XTR-1632852" ]

7

[ "4j2g", "4yk8", "5c50", "8do8" ]

4

[ "PUB00076865", "PUB00076866" ]

[ "24879146", "19225151" ]

[ "ATG13: just a companion, or an executor of the autophagic program?", "ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery." ]

[ 2014, 2009 ]

2

[]

0

null

[ "Eukaryota", "Orpheovirus IHUMI-LCC2" ]

[ 6138, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 10, 2, 1, 4, 1, 1, 9, 6, 1, 1, 21 ]

11

true

Domain

Autophagy-related protein 13, N-terminal

Atg13_N

1

IPR018733

18,733

Protein of unknown function DUF2274

DUF2274

Family

2,458

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10038" ]

[ "DUF2274" ]

[ 2458 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 3, 2428, 27 ]

3

[]

0

true

Family

Protein of unknown function DUF2274

DUF2274

7

IPR018734

18,734

Domain of unknown function DUF2275

DUF2275

Domain

212

false

This domain, found in various hypothetical bacterial proteins and in the RNA polymerase sigma factor, has no known function.

[]

0

[ "PFAM" ]

[ "PF10039" ]

[ "DUF2275" ]

[ 212 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 211, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF2275

DUF2275

5

IPR018735

18,735

Protein of unknown function DUF2277

DUF2277

Family

4,152

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10041" ]

[ "DUF2277" ]

[ 4152 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Metazoa", "metagenomes" ]

[ 4140, 2, 10 ]

3

[]

0

true

Family

Protein of unknown function DUF2277

DUF2277

4

IPR018736

18,736

Protein of unknown function DUF2279, periplasmic lipoprotein

DUF2279_periplasmic_lipo

Family

2,022

false

This domain has no known function.

[]

0

[ "PFAM" ]

[ "PF10043" ]

[ "DUF2279" ]

[ 2022 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017028" ]

0

1

0

[ "Bacteria", "Mesangiospermae", "ecological metagenomes" ]

[ 2002, 5, 15 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2279, periplasmic lipoprotein

DUF2279_periplasmic_lipo

2

IPR018737

18,737

Protein LIN52

DREAM_LIN52

Family

2,111

false

LIN52 is a component of the DREAM (MuvB/DRM) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [ , ].

[ "GO:0006355", "GO:0070176" ]

[ "regulation of DNA-templated transcription", "DRM complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10044", "PTHR31489" ]

[ "LIN52", "" ]

[ 2110, 1804 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-1538133", "R-DRE-1538133", "R-GGA-1538133", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-156711", "R-HSA-69202", "R-HSA-69205", "R-HSA-69656", "R-MMU-1538133" ]

[ "REACTOME:R-CEL-1538133", "REACTOME:R-DRE-1538133", "REACTOME:R-GGA-1538133", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-1362300", "REACTOME:R-HSA-1538133", "REACTOME:R-HSA-156711", "REACTOME:R-HSA-69202", "REACTOME:R-HSA-69205", "REACTOME:R-HSA-69656", "REACTOME:R-MMU-1538133" ]

11

[ "4yos", "6c48" ]

2

[ "PUB00067716", "PUB00067717" ]

[ "17531812", "17671431" ]

[ "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.", "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2111 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 4, 2, 3, 8 ]

7

true

Family

Protein LIN52

DREAM_LIN52

5

IPR018738

18,738

Protein of unknown function DUF2280

DUF2280

Family

842

false

This entry includes Burkholderia phage Bups phi1, Orf2.36. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF10045" ]

[ "DUF2280" ]

[ 842 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Lasius niger", "metagenomes" ]

[ 825, 13, 1, 3 ]

4

[]

0

true

Family

Protein of unknown function DUF2280

DUF2280

4

IPR018740

18,740

BufA1 family periplasmic bufferin-type metallophore

BufA1

Family

4,021

false

BufA1 family periplasmic bufferin-type metallophore belongs to a family of ribosomally synthesised and post-translationally modified peptide (RiPP) precursors that are modified by multinuclear nonheme iron-dependent oxidase (MNIO) enzymes. Unusual among RiPPs, these peptides have a Sec-dependent N-terminal signal pepti...

[ "GO:0005507" ]

[ "copper ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10048" ]

[ "BufA1" ]

[ 4021 ]

1

[]

0

[]

0

[ "PUB00161747", "PUB00161748", "PUB00161749" ]

[ "28463986", "38772214", "39602266" ]

[ "The Legionella pneumophila GIG operon responds to gold and copper in planktonic and biofilm cultures.", "Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications.", "A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal ...

[ 2017, 2024, 2024 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3969, 7, 45 ]

3

[]

0

true

Family

BufA1 family periplasmic bufferin-type metallophore

BufA1

7

IPR018741

18,741

Protein of unknown function DUF2288

DUF2288

Family

2,091

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10052" ]

[ "DUF2288" ]

[ 2091 ]

1

[]

0

[ "2lv5" ]

1

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 2070, 21 ]

2

[]

0

true

Family

Protein of unknown function DUF2288

DUF2288

6

IPR018742

18,742

Protein of unknown function DUF2290

DUF2290

Family

327

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10053" ]

[ "DUF2290" ]

[ 327 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanogenium", "metagenomes" ]

[ 321, 2, 4 ]

3

[]

0

true

Family

Protein of unknown function DUF2290

DUF2290

9

IPR018744

18,744

Domain of unknown function DUF2293

DUF2293

Domain

3,218

false

Proteins in this entry are found the bacteria and fungi, they have no known function.

[]

0

[ "PFAM" ]

[ "PF10056" ]

[ "DUF2293" ]

[ 3218 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "candidate division MSBL1", "ecological metagenomes" ]

[ 1556, 1644, 4, 14 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF2293

DUF2293

6

IPR018745

18,745

Na+-translocating membrane potential-generating system MpsC

MpsC

Domain

2,823

false

This entry corresponds to the Na+-translocating membrane potential-generating system subunit MpsC [ ].

[]

0

[ "PFAM" ]

[ "PF10057" ]

[ "MpsC" ]

[ 2823 ]

1

[]

0

[]

0

[ "PUB00098622" ]

[ "25448817" ]

[ "The Staphylococcus aureus NuoL-like protein MpsA contributes to the generation of membrane potential." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2790, 5, 28 ]

3

[]

0

true

Domain

Na+-translocating membrane potential-generating system MpsC

MpsC

4

IPR018747

18,747

Protein of unknown function DUF2299

DUF2299

Family

315

false

Members of this family of hypothetical prokaryotic proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10061" ]

[ "DUF2299" ]

[ 315 ]

1

[]

0

[ "3cxj" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Meloidogyne hapla", "ecological metagenomes" ]

[ 284, 3, 1, 27 ]

4

[]

0

true

Family

Protein of unknown function DUF2299

DUF2299

1

IPR018748

18,748

Domain of unknown function DUF2300, secreted

DUF2300_secreted

Domain

751

false

This domain, found in various bacterial hypothetical and putative signal peptide proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF10062" ]

[ "DUF2300" ]

[ 751 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Darwinula stevensoni", "human gut metagenome" ]

[ 748, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF2300, secreted

DUF2300_secreted

4

IPR018750

18,750

Protein of unknown function DUF2306, membrane

DUF2306_membrane

Family

7,755

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10067" ]

[ "DUF2306" ]

[ 7755 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 6185, 1521, 23, 26 ]

4

[]

0

true

Family

Protein of unknown function DUF2306, membrane

DUF2306_membrane

3

IPR018752

18,752

Probable inorganic carbon transporter subunit DabA

DabA

Family

3,151

false

This entry represents the probable inorganic carbon transporter subunit DabA, which is part of an energy-coupled inorganic carbon pump together with DabB subunit in DAB operons (DAB1 and DAB2), found in a wide range of bacteria and archaea. DAB operon is required for CO2 concentrating mechanisms [ ]. The substrate of t...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01871", "PF10070", "PTHR38344" ]

[ "DabA", "DabA", "" ]

[ 2848, 3151, 3135 ]

3

[]

0

[]

0

[ "PUB00093673" ]

[ "31406332" ]

[ "DABs are inorganic carbon pumps found throughout prokaryotic phyla." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteria", "unclassified sequences" ]

[ 2869, 13, 228, 41 ]

4

[]

0

true

Family

Probable inorganic carbon transporter subunit DabA

DabA

8

IPR018753

18,753

GapR-like

Family

2,324

false

GapR is a nucleoid-associated protein (NAP) critical for cellular function in Caulobacter crescentus (also known as Caulobacter vibrioides). Loss of GapR causes severe defects in growth, cell division, DNA replication, and chromosome segregation [ , ]. This is a DNA-binding protein which has mainly an α-helical seconda...

[]

0

[ "HAMAP" ]

[ "MF_00797" ]

[ "UPF0335" ]

[ 2324 ]

1

[]

0

[ "6cfx", "6cfy", "6cg8", "6jyk", "6k2j", "6ozx", "6ozy", "6ozz" ]

8

[ "PUB00100154", "PUB00100155" ]

[ "28011580", "31723182" ]

[ "Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter.", "Structures of GapR reveal a central channel which could accommodate B-DNA." ]

[ 2017, 2019 ]

2

[]

0

null

[ "Bacteria", "Bilateria", "Viruses", "unclassified sequences" ]

[ 2286, 5, 19, 14 ]

4

[]

0

true

Family

GapR-like

2

IPR018754

18,754

T6SS, Transcription factor RovC-like, DNA binding domain

RovC-like_DNA-bd

Domain

3,212

false

This domain is found in a group of proteins from proteobacteria, including the hexameric transcription factor from Yersinia pseudotuberculosis RovC, which is essential for the activation of one of the Type VI secretion systems of this organism (T6SS4). This domain folds into a distinct variant of the helix-turn-helix d...

[]

0

[ "PFAM" ]

[ "PF10074" ]

[ "RovC_DNA-bd" ]

[ 3212 ]

1

[]

0

[ "6xz5", "7uqt" ]

2

[ "PUB00152791", "PUB00152792" ]

[ "32966346", "37246713" ]

[ "RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.", "DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria." ]

[ 2020, 2023 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3179, 7, 26 ]

3

[]

0

true

Domain

T6SS, Transcription factor RovC-like, DNA binding domain

RovC-like_DNA-bd

5

IPR018755

18,755

Bacteriophage Mu-like, Gp48

Phage_Mu_Gp48

Family

3,755

false

Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins, including Gp48 from Bacteriophage Mu and other Mu-like prophages such as FluMu [ ].

[]

0

[ "PFAM" ]

[ "PF10076" ]

[ "Phage_Mu_Gp48" ]

[ 3755 ]

1

[]

0

[ "8v3w", "8v41", "8v43", "9g8s", "9gb2", "9ki1" ]

6

[ "PUB00015900" ]

[ "11922669" ]

[ "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "metagenomes" ]

[ 3615, 8, 1, 110, 21 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bacteriophage Mu-like, Gp48

Phage_Mu_Gp48

3

IPR018756

18,756

Domain of unknown function DUF2314

DUF2314

Domain

1,880

false

This domain of unkown function is found in various bacterial hypothetical proteins, as well as putative ankyrin repeat proteins.

[]

0

[ "PFAM" ]

[ "PF10077" ]

[ "DUF2314" ]

[ 1880 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Edafosvirus sp.", "Eukaryota", "ecological metagenomes" ]

[ 1871, 1, 2, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF2314

DUF2314

6

IPR018757

18,757

Protein of unknown function DUF2316

DUF2316

Family

561

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10078" ]

[ "DUF2316" ]

[ 561 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanolapillus millepedarum", "bioreactor metagenome" ]

[ 559, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF2316

DUF2316

2

IPR018758

18,758

Membrane iron-sulfur containing protein FtrD-like

FtrD-like

Domain

1,345

false

Proteins containing this domain are bacterial membrane proteins associated with the FTR1 protein, an homologous to FtrC in the FtrABCD complex. This complex is a ferric iron transporter in which the ferric iron is generated by ferrous oxidation that requires the electron transfer by iron-sulfur cluster-containing FrtD....

[]

0

[ "PFAM" ]

[ "PF10080" ]

[ "FtrD-like" ]

[ 1345 ]

1

[]

0

[]

0

[ "PUB00098620" ]

[ "22924881" ]

[ "Iron and pH-responsive FtrABCD ferrous iron utilization system of Bordetella species." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Rhodnius prolixus", "metagenomes" ]

[ 23, 1303, 1, 18 ]

4

[]

0

true

Domain

Membrane iron-sulfur containing protein FtrD-like

FtrD-like

7

IPR018759

18,759

Putative beta-barrel porin 2

BBP2_2

Family

3,252

false

This entry represents a putative β-barrel porin type 2.

[]

0

[ "PFAM" ]

[ "PF10082" ]

[ "BBP2_2" ]

[ 3252 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017465" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3203, 5, 44 ]

3

[]

0

true

Family

Putative beta-barrel porin 2

BBP2_2

7

IPR018760

18,760

Domain of unknown function DUF2326

DUF2326

Domain

1,495

false

This domain, found in bacterial proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF10088" ]

[ "DUF2326" ]

[ 1495 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 1462, 5, 11, 17 ]

4

[]

0

true

Domain

Domain of unknown function DUF2326

DUF2326

8

IPR018762

18,762

Histidine phosphotransferase ChpT, C-terminal

ChpT_C

Domain

2,680

false

This entry represents the C-terminal domain of ChpT.

[]

0

[ "PFAM" ]

[ "PF10090" ]

[ "HPTransfase" ]

[ 2680 ]

1

[]

0

[ "4fmt", "4fpp", "4qpj", "4qpk" ]

4

[ "PUB00075663", "PUB00085074" ]

[ "22949187", "26124143" ]

[ "Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus.", "Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen." ]

[ 2012, 2015 ]

2

[]

0

null

[ "Bacteria", "Hevea brasiliensis", "metagenomes" ]

[ 2658, 1, 21 ]

3

[]

0

true

Domain

Histidine phosphotransferase ChpT, C-terminal

ChpT_C

1

IPR018763

18,763

Protein of unknown function DUF2334

DUF2334

Family

3,908

false

This entry represents Uncharacterized protein YdaL from Bacillus subtilis (strain 168) and similar proteins from bacteria and archaea. YdaL has been related to polysaccharide production [ ].

[]

0

[ "PFAM" ]

[ "PF10096" ]

[ "DUF2334" ]

[ 3908 ]

1

[]

0

[]

0

[ "PUB00100142" ]

[ "28296273" ]

[ "Cyclic-di-GMP signalling meets extracellular polysaccharide synthesis in Bacillus subtilis." ]

[ 2017 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "unclassified sequences" ]

[ 121, 3723, 10, 3, 51 ]

5

[]

0

true

Family

Protein of unknown function DUF2334

DUF2334

3

IPR018764

18,764

Anti-sigma K factor RskA, C-terminal

RskA_C

Domain

12,551

false

This domain, formerly known as DUF2337, is found at the C-terminal end of the anti-sigma-K factor from Mycobacterium tuberculosis (RskA) [ , ] and similar bacterial sequences. RskA (regulator of sigma K) represses the extra-cytoplasmic function (ECF) sigma factor K (sigK) by binding to it and inhibiting its activity [ ...

[ "GO:0005886", "GO:0016020" ]

[ "plasma membrane", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF10099" ]

[ "RskA_C" ]

[ 12551 ]

1

[]

0

[]

0

[ "PUB00044881", "PUB00044882", "PUB00154216" ]

[ "18203833", "17064366", "24699647" ]

[ "Evolution of the mycobacterial SigK regulon.", "Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis.", "Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex." ]

[ 2008, 2006, 2014 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 12455, 9, 2, 85 ]

4

[]

0

true

Domain

Anti-sigma K factor RskA, C-terminal

RskA_C

7

IPR018765

18,765

Domain of unknown function DUF2341

DUF2341

Domain

1,714

false

This domain of unknown function is found in various prokaryotic proteins, including MotA/TolQ/ExbB proton channels and other transport proteins.

[]

0

[ "PFAM" ]

[ "PF10102" ]

[ "DUF2341" ]

[ 1714 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 313, 1229, 38, 20, 114 ]

5

[]

0

true

Domain

Domain of unknown function DUF2341

DUF2341

7

IPR018767

18,767

Brl1/Brr6 domain

Brl1/Brr6_dom

Domain

2,234

false

In Saccharomyces cerevisiae, Brr6 and Brl1 are interacting proteins that localise to the nuclear envelope and regulate lipid homeostasis [ ]. Mutation studies have implicated the proteins in nuclear pore complex biogenesis and mRNA nuclear export [ ], although it may be that these observed effects are due to defects in...

[ "GO:0055088", "GO:0031965" ]

[ "lipid homeostasis", "nuclear membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF10104", "SM01042" ]

[ "Brr6_like_C_C", "Brr6_like_C_C" ]

[ 2232, 2171 ]

2

[]

0

[]

0

[ "PUB00044174", "PUB00044883", "PUB00083815", "PUB00083826" ]

[ "15882446", "11483521", "26432634", "22042620" ]

[ "Brl1p -- a novel nuclear envelope protein required for nuclear transport.", "An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport.", "Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore...

[ 2005, 2001, 2015, 2011 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2234 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Domain

Brl1/Brr6 domain

Brl1/Brr6_dom

8

IPR018769

18,769

Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345

VgrG2_DUF2345

Domain

7,704

false

Type VI secretion system (T6SS) appears to be confined to Proteobacteria. It is important for bacterial pathogenesis, but it is also found in non-pathogenic bacteria, suggesting that T6SS involvement is not limited to virulence [ ]. T6SS was identified in Vibrio cholerae [ ] and Pseudomonas aeruginosa [ ], and exports ...

[]

0

[ "PFAM" ]

[ "PF10106" ]

[ "DUF2345" ]

[ 7704 ]

1

[]

0

[ "6sjl", "6sk0", "6ski" ]

3

[ "PUB00034462", "PUB00042938", "PUB00067798", "PUB00067801", "PUB00100134", "PUB00100135", "PUB00100136", "PUB00100137" ]

[ "16763151", "16432199", "15385502", "19284603", "31577948", "32350888", "31231326", "26037124" ]

[ "A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.", "Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.", "Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.", "Di...

[ 2006, 2006, 2004, 2009, 2019, 2020, 2019, 2015 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Peduoviridae", "unclassified sequences" ]

[ 7633, 34, 2, 35 ]

4

[]

0

true

Domain

Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345

VgrG2_DUF2345

2

IPR018770

18,770

5-bromo-4-chloroindolyl phosphate hydrolysis protein

ChloroindolylP_hydrolase

Family

3,263

false

This entry consists of prokaryotic proteins that mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.

[]

0

[ "PFAM" ]

[ "PF10112" ]

[ "Halogen_Hydrol" ]

[ 3263 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3234, 29 ]

2

[]

0

true

Family

5-bromo-4-chloroindolyl phosphate hydrolysis protein

ChloroindolylP_hydrolase

2

IPR018771

18,771

PocR domain

PocR_dom

Domain

4,090

false

PocR, a ligand binding domain, has a novel variant of the PAS-like fold [ ]. Evidence suggests that it binds small hydrocarbon derivatives such as 1,3-propanediol [ ].

[]

0

[ "PFAM" ]

[ "PF10114" ]

[ "PocR" ]

[ 4090 ]

1

[]

0

[]

0

[ "PUB00057237" ]

[ "15814558" ]

[ "MEDS and PocR are novel domains with a predicted role in sensing simple hydrocarbon derivatives in prokaryotic signal transduction systems." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 244, 3775, 21, 50 ]

4

[]

0

true

Domain

PocR domain

PocR_dom

6

IPR018772

18,772

Transcription activator HlyU

Transcription_activator_HlyU

Family

1,571

false

This is a family of hypothetical prokaryotic proteins, with no known function. One of the proteins in this entry corresponds to the transcriptional activator HlyU, indicating a possible similar role in other members.

[]

0

[ "PFAM" ]

[ "PF10115" ]

[ "HlyU" ]

[ 1571 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1560, 11 ]

2

[]

0

true

Family

Transcription activator HlyU

Transcription_activator_HlyU

8

IPR018773

18,773

Methyltransferase regulatory domain, predicted

MeTrfase_reg_dom_prd

Domain

2,057

false

This entry represents a sequence region found in various prokaryotic methyltransferases that regulates the activity of the methyltransferase domain.

[]

0

[ "PFAM" ]

[ "PF10119" ]

[ "MethyTransf_Reg" ]

[ 2057 ]

1

[]

0

[ "5dnk", "5do0", "5doo", "5dpd", "5dpl" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2044, 4, 9 ]

3

[]

0

true

Domain

Methyltransferase regulatory domain, predicted

MeTrfase_reg_dom_prd

5

IPR018774

18,774

Bacteriophage Mu, GpT

Phage_Mu_GpT

Domain

1,578

false

This entry represents a conserved domain found in various caudoviral prophage proteins, including the bacteriophage Mu major head subunit GpT and related prophage.

[]

0

[ "PFAM" ]

[ "PF10124" ]

[ "Mu-like_gpT" ]

[ 1578 ]

1

[]

0

[ "8rkc", "8rkn", "8rko", "8rkx", "8rqe", "9jod" ]

6

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina", "Protostomia", "Viruses", "unclassified sequences" ]

[ 1465, 3, 6, 59, 45 ]

5

[]

0

true

Domain

Bacteriophage Mu, GpT

Phage_Mu_GpT

6

IPR018775

18,775

RNA repair pathway DNA polymerase beta

RlaP

Family

7,859

false

This entry represents a group of proteins that belong to the DNA polymerase beta superfamily, with closest affinities to the Minimal Nucleotide Transferase clade (MNT). They are found in diverse RNA repair genome contexts centred on both RtcB and Rnl-type (ATP-grasp fold) repair ligases [ ]. Members of this family of b...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10127", "PTHR34817" ]

[ "RlaP", "" ]

[ 7830, 7497 ]

2

[]

0

[]

0

[ "PUB00091037" ]

[ "27536007" ]

[ "RNA damage in biological conflicts and the diversity of responding RNA repair systems." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 106, 6904, 193, 563, 93 ]

5

[]

0

true

Family

RNA repair pathway DNA polymerase beta

RlaP

2

IPR018776

18,776

Membrane protein, 6-pyruvoyl-tetrahydropterin synthase-related domain

Membrane_prot_PTPS-rel_domain

Domain

711

false

This entry is found in various bacterial and archaeal hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. Its function has not yet been established, though it shows similarity to 6-pyruvoyl-tetrahydropterin synthase.

[]

0

[ "PFAM" ]

[ "PF10131" ]

[ "PTPS_related" ]

[ 711 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Ricinus communis", "ecological metagenomes" ]

[ 34, 643, 1, 33 ]

4

[]

0

true

Domain

Membrane protein, 6-pyruvoyl-tetrahydropterin synthase-related domain

Membrane_prot_PTPS-rel_domain

4

IPR018777

18,777

Replication initiator protein A

Replication_initiator_prot_A

Family

4,149

false

Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.

[]

0

[ "PFAM" ]

[ "PF10134" ]

[ "RPA" ]

[ 4149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Plasmid pEMT8", "unclassified sequences" ]

[ 4081, 4, 15, 1, 48 ]

5

[]

0

true

Family

Replication initiator protein A

Replication_initiator_prot_A

1

IPR018778

18,778

Type VII secretion system EssB

T7SS_EssB

Family

1,093

false

Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This protein is designated YukC in Bacillus subtilis and EssB is Staphylococcus aureus.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF10140", "TIGR03926" ]

[ "YukC", "T7_EssB" ]

[ 1093, 898 ]

2

[ "GP" ]

[ "GenProp0905" ]

[ "GP:GenProp0905" ]

1

[ "2ynq", "4ann", "4ano", "6z0f" ]

4

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "uncultured prokaryote" ]

[ 1091, 1, 1 ]

3

[]

0

true

Family

Type VII secretion system EssB

T7SS_EssB

7

IPR018780

18,780

BLOC-1-related complex subunit 5

TBORCS5

Family

1,809

false

This entry includes the subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it re...

[ "GO:0032418" ]

[ "lysosome localization" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10158", "PTHR31634" ]

[ "LOH1CR12", "" ]

[ 1780, 1770 ]

2

[]

0

[]

0

[ "PUB00082308" ]

[ "25898167" ]

[ "BORC, a multisubunit complex that regulates lysosome positioning." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1809 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 15, 2, 2, 2 ]

6

true

Family

BLOC-1-related complex subunit 5

TBORCS5

1

IPR018781

18,781

Transmembrane protein TPRA1/CAND2/CAND8

TPRA1/CAND2/CAND8

Family

2,493

false

This family of membrane proteins are conserved from plants to humans, including CAND2 and CAND8 from Arabidopsis. CAND2 and CAND8 are predicted G-protein coupled receptors [ ]. CAND2 plays a role in plants and microbes interactions [ ] and acts as a phytomelatonin receptor that regulates stomatal closure through the Ga...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10160", "PTHR15876" ]

[ "Tmemb_40", "" ]

[ 2491, 2424 ]

2

[]

0

[]

0

[ "PUB00093390", "PUB00093391", "PUB00093392" ]

[ "22206669", "18671868", "29702752" ]

[ "Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved in Arabidopsis root growth mediated by the bacterial quorum-sensing signals N-acyl-homoserine lactones.", "Whole proteome identification of plant candidate G-protein coupled receptors in Arabidopsis, rice, and poplar: computational predicti...

[ 2012, 2008, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2493 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 8, 4, 7, 3, 5, 11 ]

8

true

Family

Transmembrane protein TPRA1/CAND2/CAND8

TPRA1/CAND2/CAND8

7

IPR018782

18,782

Essential MCU regulator, mitochondrial

MCU_reg

Family

1,282

false

Essential MCU regulator (EMRE) is a component of the mitochondrial calcium uniporter complex in metazoa, a complex that mediates calcium uptake into mitochondria. It bridges the calcium-sensing components of the complex, MICU1 and MICU2, and the pore-forming subunit MCU, and it is essential for the complex uniporter ac...

[ "GO:0036444", "GO:0051560", "GO:1990246" ]

[ "calcium import into the mitochondrion", "mitochondrial calcium ion homeostasis", "uniplex complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF10161", "PTHR33904" ]

[ "DDDD", "" ]

[ 1281, 1202 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8949215", "R-BTA-8949664", "R-BTA-9837999", "R-CEL-8949215", "R-CEL-8949664", "R-CEL-9837999", "R-DME-8949215", "R-DME-8949664", "R-DME-9837999", "R-HSA-8949215", "R-HSA-8949664", "R-HSA-9837999", "R-MMU-8949215", "R-MMU-8949664", "R-MMU-9837999" ]

[ "REACTOME:R-BTA-8949215", "REACTOME:R-BTA-8949664", "REACTOME:R-BTA-9837999", "REACTOME:R-CEL-8949215", "REACTOME:R-CEL-8949664", "REACTOME:R-CEL-9837999", "REACTOME:R-DME-8949215", "REACTOME:R-DME-8949664", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-8949215", "REACTOME:R-HSA-8949664", "REACTOM...

15

[ "6k7x", "6k7y", "6o58", "6o5b", "6wdn", "6wdo", "6x4s", "6xjv", "6xjx", "6xqn" ]

10

[ "PUB00081393" ]

[ "24231807" ]

[ "EMRE is an essential component of the mitochondrial calcium uniporter complex." ]

[ 2013 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1282 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3, 1, 3, 4 ]

6

true

Family

Essential MCU regulator, mitochondrial

MCU_reg

8

IPR018784

18,784

LLP homolog-like

LLPH-like

Family

1,425

false

This entry represents a family of LLP homolog (LLPH) animal proteins, including 18 kDa learning-associated protein of slug from Lehmannia marginata (LAPS18), which functions in the regulation of neuronal cell adhesion and/or movement and synapse attachment [ ]. It has been shown to bind to the ApC/EBP (Aplysia CCAAT/en...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10169", "PTHR34253" ]

[ "LLPH", "" ]

[ 1424, 1312 ]

2

[]

0

[ "6lss", "6lu8", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8fkz", "8fl0", "8fl2", "8fl3", "8fl4", "8fl6", "8fl7", "8fl9", "8fla", "8flb", "8flc", "8fld", "8fle", "8flf", "8idt", "8idy", "8ie3", "8ine", "8inf", "8ink", "8ipd", "8ipx", "8ipy", "8ir1"...

35

[ "PUB00044326", "PUB00044327", "PUB00101115", "PUB00101554" ]

[ "11168596", "16504946", "26961175", "32669547" ]

[ "Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug.", "A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons.", "A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis...

[ 2001, 2006, 2016, 2020 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 1425 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 2, 2 ]

6

true

Family

LLP homolog-like

LLPH-like

1

IPR018785

18,785

Cysteine-rich DPF motif domain

CDPF1_dom

Domain

1,311

false

This entry represents the cysteine-rich DPF motif domain (CDPF1) in CDPF1-containing proteins found in a range of organisms, including human, chicken and Drosophila [ , , ]. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. The function of this protein has not...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF10170", "PR01995" ]

[ "C6_DPF", "UPF0595" ]

[ 1310, 1196 ]

2

[]

0

[]

0

[ "PUB00053648", "PUB00053649", "PUB00053650" ]

[ "10591208", "15642098", "12537572" ]

[ "The DNA sequence of human chromosome 22.", "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.", "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." ]

[ 1999, 2005, 2002 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1311 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 2, 4, 2, 1 ]

6

true

Domain

Cysteine-rich DPF motif domain

CDPF1_dom

7

IPR018786

18,786

Mitochondrial K+-H+ exchange-related

Mit_KHE1

Family

2,520

false

This entry represents a family of proteins from fungi, plants and bacteria, including Uncharacterized protein YDL183C from Saccharomyces cerevisiae, which may be part of an active mitochondrial K+/H+ exchanger (KHE) system [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10173", "PTHR28062" ]

[ "Mit_KHE1", "" ]

[ 2500, 2429 ]

2

[]

0

[]

0

[ "PUB00101048" ]

[ "20197279" ]

[ "Novel components of an active mitochondrial K(+)/H(+) exchange." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati", "marine metagenome" ]

[ 2503, 13, 4 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 5, 1, 2, 1, 1, 6 ]

6

true

Family

Mitochondrial K+-H+ exchange-related

Mit_KHE1

5

IPR018787

18,787

Protein of unknown function DUF2371, TMEM200

DUF2371_TMEM200

Family

3,144

false

This family of proteins with no known function is conserved from nematodes to humans. It includes members of the TMEM200 family of transmembrane proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10177", "PTHR31815" ]

[ "DUF2371", "" ]

[ 2995, 3110 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria", "Massilimicrobiota timonensis" ]

[ 3143, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 11, 3, 5, 7, 6 ]

6

true

Family

Protein of unknown function DUF2371, TMEM200

DUF2371_TMEM200

6

IPR018788

18,788

Proteasome assembly chaperone 3

Proteasome_assmbl_chp_3

Family

3,300

false

Proteasome assembly chaperone 3 (PSMG3) promotes assembly of the 20S proteasome [ ]. It may cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.

[ "GO:0043248" ]

[ "proteasome assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10178", "PTHR31051" ]

[ "PAC3", "" ]

[ 2503, 3077 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9907900", "R-DDI-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-SPO-9907900" ]

[ "REACTOME:R-BTA-9907900", "REACTOME:R-DDI-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-SPO-9907900" ]

5

[ "2z5e", "6jpt", "8qyj", "8tm3" ]

4

[ "PUB00044884" ]

[ "17189198" ]

[ "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3300 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Ze...

[ 2, 1, 1, 1, 2, 1, 7, 2, 1, 17 ]

10

true

Family

Proteasome assembly chaperone 3

Proteasome_assmbl_chp_3

7

IPR018789

18,789

Flocculin 11 domain

Flo11

Domain

346

false

Fungal cells need to be able to adhere to their surroundings, be it either abiotic surfaces or living tissues, in order to remain firmly attached to their source of nutrients. Adhesive properties in fungi are conveyed by a group of cell-surface proteins called adhesins (sometimes also referred to as agglutinins or floc...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF10182", "PS51824", "SM01213" ]

[ "Flo11", "FLO11", "Flo11" ]

[ 305, 343, 279 ]

3

[]

0

[ "4uyr", "4uys", "4uyt", "5fv5", "5fv6" ]

5

[ "PUB00045059", "PUB00087112", "PUB00087113" ]

[ "17870620", "22129043", "25960408" ]

[ "Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts.", "The N-terminal domain of the Flo11 protein from Saccharomyces cerevisiae is an adhesin without mannose-binding activity.", "Interactions by the Fungal Flo11 Adhesin Depend on a Fibro...

[ 2008, 2012, 2015 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 346 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

Flocculin 11 domain

Flo11

5

IPR018790

18,790

Protein of unknown function DUF2358

DUF2358

Family

6,987

false

This entry represents a family of conserved proteins. The function is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10184", "PTHR31094" ]

[ "DUF2358", "" ]

[ 6145, 3707 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 488, 6498, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 31, 1, 1, 2, 9, 10, 1, 16, 5, 34 ]

10

true

Family

Protein of unknown function DUF2358

DUF2358

1

IPR018791

18,791

UV radiation resistance protein/autophagy-related protein 14

UV_resistance/autophagy_Atg14

Family

6,755

false

This entry includes Atg14 (autophagy-related protein 14) from budding yeasts and their homologues, Atg14L/Bakor (beclin-1-associated autophagy-related key regulator) and UVRAG (UV irradiation resistance-associated gene), from animals. Atg14 is a hydrophilic protein with a coiled-coil motif at the N terminus region. Yea...

[]

0

[ "PFAM" ]

[ "PF10186" ]

[ "ATG14" ]

[ 6755 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1632852", "R-HSA-9679504", "R-HSA-9694676", "R-HSA-9705671", "R-HSA-9754560", "R-HSA-983170", "R-MMU-1632852", "R-RNO-1632852", "R-SPO-1632852" ]

[ "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-9679504", "REACTOME:R-HSA-9694676", "REACTOME:R-HSA-9705671", "REACTOME:R-HSA-9754560", "REACTOME:R-HSA-983170", "REACTOME:R-MMU-1632852", "REACTOME:R-RNO-1632852", "REACTOME:R-SPO-1632852" ]

9

[ "7bl1", "8sor", "9c82", "9mhf", "9mhg", "9mhh" ]

6

[ "PUB00009843", "PUB00054114", "PUB00054155", "PUB00055555", "PUB00077159", "PUB00084155" ]

[ "9712845", "11157979", "19050071", "18843052", "20643123", "16799551" ]

[ "Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.", "Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.", "Identification of Barkor as a mammalian autophagy-spec...

[ 1998, 2001, 2008, 2008, 2010, 2006 ]

6

[]

[ "IPR023261" ]

0

1

0

[ "Eukaryota" ]

[ 6755 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 23, 13, 1, 7, 5, 2, 5, 5, 1, 1, 24 ]

11

true

Family

UV radiation resistance protein/autophagy-related protein 14

UV_resistance/autophagy_Atg14

1

IPR018792

18,792

Nuclear protein 1-like

NUPR1-like

Family

1,184

false

This entry represents a group of nuclear proteins that are conserved from nematodes to humans. They can form a helix-loop-helix motif and are related to, yet distinct from, the HMG-I/Y-like subfamily of HMG proteins. This entry includes two human nuclear proteins, NUPR1 (also known as p8) and NUPR2. Similar to several ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10195", "PTHR17149" ]

[ "Phospho_p8", "" ]

[ 1183, 988 ]

2

[]

0

[]

0

[ "PUB00077980", "PUB00077982", "PUB00077983", "PUB00077984" ]

[ "19650074", "22858377", "22565310", "25056123" ]

[ "p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.", "Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.", "Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting...

[ 2009, 2012, 2012, 2014 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1184 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3, 2, 4 ]

6

true

Family

Nuclear protein 1-like

NUPR1-like

7

IPR018793

18,793

Cytochrome c oxidase assembly protein PET191

Cyt_c_oxidase_assmbl_Pet191

Family

3,374

false

This entry represents a family of conserved proteins found from nematodes to humans. Cytochrome c oxidase assembly protein Pet191 carries six highly conserved cysteine residues. Pet191 is required for the assembly of active cytochrome c oxidase but does not form part of the final assembled complex [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10203", "PTHR28627" ]

[ "Pet191_N", "" ]

[ 3371, 3195 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9864848", "R-DRE-9864848", "R-HSA-9864848", "R-MMU-9864848" ]

[ "REACTOME:R-BTA-9864848", "REACTOME:R-DRE-9864848", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

4

[]

0

[ "PUB00044429" ]

[ "8381337" ]

[ "Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae." ]

[ 1993 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3374 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 2, 1, 1, 2, 2, 1, 1, 5 ]

12

true

Family

Cytochrome c oxidase assembly protein PET191

Cyt_c_oxidase_assmbl_Pet191

6

IPR018794

18,794

Uncharacterised protein family UPF0538

UPF0538

Family

1,861

false

This entry consists of small proteins of approximately 150 amino acids whose function is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10209", "PTHR18444" ]

[ "DUF2340", "" ]

[ 1861, 1818 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1861 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2, 13, 1, 1 ]

6

true

Family

Uncharacterised protein family UPF0538

UPF0538

1

IPR018795

18,795

Uncharacterized protein KIAA2013-like

K2013-like

Family

2,179

false

This entry represents Uncharacterized protein KIAA2013 and similar proteins from animals. K2013 might be related to cannabinoid receptors [ ] and neurodegenerative disorders such as ALS [ ]. The function of this protein is still unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10222", "PTHR31386" ]

[ "DUF2152", "" ]

[ 2171, 2166 ]

2

[]

0

[]

0

[ "PUB00099528", "PUB00099529" ]

[ "31616248", "33327559" ]

[ "Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.", "Alzheimer's, Parkinson's Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement." ]

[ 2019, 2020 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2179 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 1, 3 ]

6

true

Family

Uncharacterized protein KIAA2013-like

K2013-like

1

IPR018796

18,796

Cytochrome c oxidase assembly factor 8

COA8

Family

2,045

false

Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway [ ], is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS) [ ]. In Drosoph...

[ "GO:0097193" ]

[ "intrinsic apoptotic signaling pathway" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10231", "PTHR31107" ]

[ "COA8", "" ]

[ 2040, 1918 ]

2

[]

0

[]

0

[ "PUB00086677", "PUB00093669", "PUB00093671" ]

[ "16782708", "30552096", "31555154" ]

[ "Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.", "APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.", "Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxi...

[ 2006, 2019, 2019 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 2045 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 11, 10, 4, 5 ]

6

true

Family

Cytochrome c oxidase assembly factor 8

COA8

4

IPR018797

18,797

FAM98

Family

3,516

false

FAM98A, B and C are glycine-rich proteins found from worms to humans. FAM98A contains a tubulin-binding calponin homology domain. It interacts with PLEKHM1 and functions in lysosome positioning in osteoclasts [ ]. FAM98A and FAM98B are included in a novel complex with DDX1 and C14orf166 and are involved in colorectal c...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10239", "PTHR31353" ]

[ "DUF2465", "" ]

[ 3508, 3444 ]

2

[ "GP", "REACTOME" ]

[ "GenProp1707", "R-HSA-6784531" ]

[ "GP:GenProp1707", "REACTOME:R-HSA-6784531" ]

2

[ "9i8v" ]

1

[ "PUB00086684", "PUB00086685" ]

[ "27777970", "28040436" ]

[ "PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.", "FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression." ]

[ 2016, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3516 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 18, 10, 10 ]

6

true

Family

FAM98

4

IPR018799

18,799

TRAF3-interacting protein 1

TRAF3IP1

Family

2,578

false

TRAF3-interacting protein 1 (TRAF3IP1, also known as IFT54) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans [ ]. The N-terminal region is the microtubule binding domain and is well-conserved; the C-te...

[ "GO:0008017" ]

[ "microtubule binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR31363" ]

[ "" ]

[ 2578 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5620924", "R-MMU-5620924", "R-RNO-5620924" ]

[ "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5620924", "REACTOME:R-RNO-5620924" ]

3

[ "2eqo", "5fmt", "5fmu", "8bd7", "8glv", "8kcq", "8ruy" ]

7

[ "PUB00044362", "PUB00063569", "PUB00063570" ]

[ "10791955", "12812986", "12935900" ]

[ "MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.", "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.", "MIP-T3 associates wi...

[ 2000, 2003, 2003 ]

3

[]

0

null

[ "Bacteria", "Cyprinid herpesvirus 1", "Eukaryota", "termite gut metagenome" ]

[ 9, 1, 2567, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 16, 1, 2, 2, 6 ]

6

true

Family

TRAF3-interacting protein 1

TRAF3IP1

7

IPR018800

18,800

Proline-rich protein PRCC

PRCC

Family

3,925

false

This family constitutes the major, conserved, portion of PRCC proteins. In humans, this family interacts with MAD2B, the mitotic checkpoint protein [ , ]. In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10253", "PTHR13621" ]

[ "PRCC", "" ]

[ 3689, 3671 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-DDI-72163", "R-HSA-72163" ]

[ "REACTOME:R-DDI-72163", "REACTOME:R-HSA-72163" ]

2

[]

0

[ "PUB00008533", "PUB00045083", "PUB00066678" ]

[ "11884590", "8986805", "11717438" ]

[ "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.", "Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.", "Im...

[ 2002, 1996, 2001 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3925 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 6, 1, 1, 1, 7, 2, 1, 2, 4, 1, 8 ]

11

true

Family

Proline-rich protein PRCC

PRCC

5

IPR018801

18,801

E3 ubiquitin-protein ligase TM129

TM129

Family

1,675

false

TM129 (also known as TMEM129) is a tri-spanning ER-membrane protein that can serve as an E3 ligase involved in ER-associated protein degradation [ , ].

[ "GO:0061630", "GO:0016567", "GO:0016020" ]

[ "ubiquitin protein ligase activity", "protein ubiquitination", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF10272", "PTHR31322" ]

[ "Tmpp129", "" ]

[ 1672, 1648 ]

2

[ "EC", "METACYC", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-8866654" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-8866654" ]

3

[]

0

[ "PUB00086681", "PUB00086683" ]

[ "24807418", "27854284" ]

[ "A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.", "The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein." ]

[ 2014, 2016 ]

2

[]

0

null

[ "Eukaryota", "Paenibacillus woosongensis" ]

[ 1674, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 3, 2, 2 ]

6

true

Family

E3 ubiquitin-protein ligase TM129

TM129

9

IPR018802

18,802

Latarcin precursor

Latarcin_precursor

Family

31

false

This entry represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi [ ]. Latarcins are likely to adopt amphipathic α-helical structure in the plasma membrane.

[]

0

[ "PFAM" ]

[ "PF10279" ]

[ "Latarcin" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00044328" ]

[ "16735513" ]

[ "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." ]

[ 2006 ]

1

[]

0

null

[ "Lachesana tarabaevi" ]

[ 31 ]

1

[]

0

true

Family

Latarcin precursor

Latarcin_precursor

2

IPR018803

18,803

Ish1/Msc1-like

Repeat

1,960

false

Proteins containing this repeat include the stress response protein Ish1 from fission yeasts and meiotic sister chromatid recombination protein 1 (Msc1) from budding yeasts. Proteins containing this repeat also include some uncharacterised proteins from Acinetobacter baumannii. Ish1 has a role in maintaining cell viabi...

[]

0

[ "PFAM" ]

[ "PF10281" ]

[ "Ish1" ]

[ 1960 ]

1

[]

0

[]

0

[ "PUB00070797", "PUB00070798" ]

[ "11751918", "10511544" ]

[ "The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.", "Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination." ]

[ 2002, 1999 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Vieuvirus", "marine sediment metagenome" ]

[ 40, 1917, 2, 1 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Repeat

Ish1/Msc1-like

8

IPR018805

18,805

Cell wall protein YJL171C/Tos1, C-terminal

YJL171C/Tos1_C

Domain

1,426

false

This entry represents a domain found in a group of fungal cell wall proteins, including Probable circularly permuted 1,3-beta-glucanase Tos1 and YJL171C from budding yeasts [ ]. They contain 5 highly conserved cysteines, two of which form a characteristic CGC sequence motif. This proteins are related to glycosyl hydrol...

[]

0

[ "PFAM" ]

[ "PF10287" ]

[ "YJL171C_Tos1_C" ]

[ 1426 ]

1

[ "EC" ]

[ "3.2.1.39" ]

[ "EC:3.2.1.39" ]

1

[]

0

[ "PUB00097737" ]

[ "20016268" ]

[ "TOS1 is circularly permuted 1,3-beta-glucanase." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Myxococcota" ]

[ 1412, 14 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 1 ]

3

true

Domain

Cell wall protein YJL171C/Tos1, C-terminal

YJL171C/Tos1_C

1

IPR018807

18,807

Cell wall protein YJL171C/Tos1, N-terminal

YJL171C/Tos1_N

Domain

1,352

false

This entry represents a domain found in a group of fungal cell wall proteins, including Probable circularly permuted 1,3-beta-glucanase Tos1 and YJL171C from budding yeasts. This proteins are related to glycosyl hydrolases [ ]. The function of this glycine-rich domain is unknown.

[]

0

[ "PFAM" ]

[ "PF10290" ]

[ "YJL171C_Tos1_N" ]

[ 1352 ]

1

[ "EC" ]

[ "3.2.1.39" ]

[ "EC:3.2.1.39" ]

1

[]

0

[ "PUB00097737" ]

[ "20016268" ]

[ "TOS1 is circularly permuted 1,3-beta-glucanase." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 1318, 34 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 1 ]

3

true

Domain

Cell wall protein YJL171C/Tos1, N-terminal

YJL171C/Tos1_N

7

IPR018808

18,808

Muniscin, C-terminal

Muniscin_C

Domain

8,081

false

The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muni...

[]

0

[ "PFAM" ]

[ "PF10291" ]

[ "muHD" ]

[ 8081 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8856825", "R-HSA-8856828", "R-MMU-8856825", "R-MMU-8856828", "R-RNO-8856825", "R-RNO-8856828", "R-SCE-8856828", "R-SPO-8856828" ]

[ "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-8856825", "REACTOME:R-MMU-8856828", "REACTOME:R-RNO-8856825", "REACTOME:R-RNO-8856828", "REACTOME:R-SCE-8856828", "REACTOME:R-SPO-8856828" ]

8

[ "3g9h", "5awr", "5aws", "5awt", "5awu", "5jp2", "6a9y" ]

7

[ "PUB00057692" ]

[ "19713939" ]

[ "Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation." ]

[ 2009 ]

1

[ "IPR028565" ]

[ "IPR037984", "IPR049609" ]

1

2

0

[ "Eukaryota", "bird metagenome" ]

[ 8080, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 38, 4, 27, 7, 1, 3, 18, 1, 1, 2 ]

12

true

Domain

Muniscin, C-terminal

Muniscin_C

4

IPR018809

18,809

Protein of unknown function DUF2406

DUF2406

Family

1,444

false

This entry represents a family of small proteins conserved in fungi. The function is not known.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10295", "PTHR28186" ]

[ "DUF2406", "" ]

[ 1424, 1413 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1444 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2 ]

3

true

Family

Protein of unknown function DUF2406

DUF2406

1

IPR018810

18,810

Uncharacterised protein family UPF0662

UPF0662

Family

1,824

false

This entry represents a family of proteins conserved in fungi whose function is unknown. It includes Cu(2+) suppressing and bleomycin sensitive protein 1 thought to be involved in bleomycin tolerance with links to DNA repair and/or proteasome function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10303", "PTHR28086" ]

[ "DUF2408", "" ]

[ 1795, 1799 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Fusobacterium nucleatum" ]

[ 1823, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Uncharacterised protein family UPF0662

UPF0662

7

IPR018811

18,811

MIOREX complex component 11

MRX11

Family

1,593

false

MIOREX complex component 11 (MRX11) associates with mitochondrial ribosome [ ]. Its function is not clear. MIOREX complex is a large expressome-like assembly of ribosomes with factors involved in all the steps of post-transcriptional gene expression.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10306", "PTHR28002" ]

[ "FLILHELTA", "" ]

[ 1502, 1470 ]

2

[]

0

[]

0

[ "PUB00076405" ]

[ "25683707" ]

[ "Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1593 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

MIOREX complex component 11

MRX11

4

IPR018812

18,812

Swiss Army Knife RNA repair protein, HAD domain

SAK_HAD

Domain

1,397

false

This entry represents the HAD domain found in the so-called 'Swiss Army Knife' (SAK) repair protein, which is predicted to play a role in RNA repair. SAK may be involved in phosphate group removal during RNA re-ligation [ ]. There are two characteristic sequence motifs, GGWW and TGR.

[]

0

[ "PFAM" ]

[ "PF10307" ]

[ "HAD_SAK_1" ]

[ 1397 ]

1

[]

0

[]

0

[ "PUB00091037" ]

[ "27536007" ]

[ "RNA damage in biological conflicts and the diversity of responding RNA repair systems." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota", "Viruses", "marine sediment metagenome" ]

[ 1388, 8, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Swiss Army Knife RNA repair protein, HAD domain

SAK_HAD

4

IPR018814

18,814

Maintenance of telomere capping protein 1

MTC1

Family

1,726

false

This entry represents maintenance of telomere capping protein 1 (Mtc1) found in fungi which may interact with ribosomes [ ] and is synthetically lethal with cdc13-1 [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10310", "PTHR28265" ]

[ "DUF5427", "" ]

[ 1718, 1712 ]

2

[]

0

[]

0

[ "PUB00035474", "PUB00059200" ]

[ "16702403", "18845848" ]

[ "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.", "A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae." ]

[ 2006, 2008 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1726 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Maintenance of telomere capping protein 1

MTC1

7

IPR018815

18,815

Increased loss of mitochondrial DNA protein 1

Incr_loss_mito_DNA_1

Family

1,139

false

This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae (Baker's yeast) and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the con...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10311", "PTHR28029" ]

[ "Ilm1", "" ]

[ 1129, 1129 ]

2

[]

0

[]

0

[ "PUB00044317" ]

[ "17151231" ]

[ "The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1139 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Increased loss of mitochondrial DNA protein 1

Incr_loss_mito_DNA_1

6

IPR018816

18,816

Splicing factor cactin, central domain

Cactin_central

Domain

4,472

false

This entry represents the conserved central domain of the splicing factor cactin. It contains two of three predicted coiled-coil motifs. Most proteins containing this domain also have at the C-terminal end. Upstream of this domain in Drosophila proteins are a serine-rich region, some non-typical RD motifs and three pre...

[]

0

[ "PFAM" ]

[ "PF10312" ]

[ "Cactin_mid" ]

[ 4472 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-DME-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

5

[ "7w5a", "7w5b", "8c6j", "9fmd" ]

4

[ "PUB00044178" ]

[ "10842059" ]

[ "Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 4470 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 8, 1, 4, 4, 4, 4, 1, 6, 3, 1, 13 ]

11

true

Domain

Splicing factor cactin, central domain

Cactin_central

4

IPR018818

18,818

Sin3 binding protein

Stb3

Family

1,196

false

This entry represents Sin3 binding proteins conserved in fungi. Sin3p does not bind DNA directly even though the yeast SIN3 gene functions as a transcriptional repressor. Sin3p is part of a large multiprotein complex [ ]. Stb3 appears to bind directly to ribosomal RNA Processing Elements (RRPE) although there are no ob...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10330", "PTHR28164" ]

[ "Stb3", "" ]

[ 1190, 1183 ]

2

[]

0

[]

0

[ "PUB00044498", "PUB00044499" ]

[ "9393435", "17616518" ]

[ "Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins.", "Stb3 binds to ribosomal RNA processing element motifs that control transcriptional responses to growth in Saccharomyces cerevisiae." ]

[ 1997, 2007 ]

2

[]

0

null

[ "Botrimarina hoheduenensis", "Dikarya" ]

[ 1, 1195 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Sin3 binding protein

Stb3

5

IPR018819

18,819

Nur1/Mug154

Family

1,702

false

This entry includes Nur1 from budding yeasts and Mug154 from fission yeasts. Nur1 is part of the perinuclear network that controls recombination at multiple loci to maintain genome stability [ ]. Mug15 may has a role in meiosis [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10332", "PTHR28293" ]

[ "DUF2418", "" ]

[ 1676, 1653 ]

2

[]

0

[]

0

[ "PUB00044889", "PUB00092502" ]

[ "16303567", "18997772" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "Role for perinuclear chromosome tethering in maintenance of genome stability." ]

[ 2005, 2008 ]

2

[]

0

null

[ "Eukaryota", "Methanocalculus chunghsingensis" ]

[ 1701, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Nur1/Mug154

6

IPR018820

18,820

Brefeldin A sensitivity protein-related, domain of unknown function DUF2421

BRE4-related_DUF2421

Domain

4,786

false

This domain is found in several uncharacterised proteins and in Brefeldin A-sensitivity protein 4, which is a zinc finger protein containing five transmembrane domains. Brefeldin A-sensitivity protein 4 null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect int...

[]

0

[ "PFAM" ]

[ "PF10334" ]

[ "BRE4" ]

[ 4786 ]

1

[]

0

[]

0

[ "PUB00004475", "PUB00019467", "PUB00053688" ]

[ "9171100", "11169758", "11378903" ]

[ "Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins.", "Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport.", "Identification and characterization of Saccharomyces c...

[ 1997, 2001, 2001 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4786 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2 ]

2

true

Domain

Brefeldin A sensitivity protein-related, domain of unknown function DUF2421

BRE4-related_DUF2421

3

IPR018821

18,821

Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding

DUF294_put_nucleoTrafse_sb-bd

Domain

9,160

false

This entry is found associated with presumed nucleotidyltransferase domains and seems to be distantly related to other helical substrate binding domains.

[]

0

[ "PFAM" ]

[ "PF10335" ]

[ "DUF294_C" ]

[ 9160 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 27, 9067, 18, 48 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding

DUF294_put_nucleoTrafse_sb-bd

9

IPR018822

18,822

Uncharacterised protein family UPF0646

UPF0646

Family

1,383

false

This entry represents a family of proteins conserved in fungi. Their function is not known.

[]

0

[ "PFAM" ]

[ "PF10336" ]

[ "DUF2420" ]

[ 1383 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1383 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Uncharacterised protein family UPF0646

UPF0646

7

IPR018823

18,823

Putative ER transporter, 6TM, N-terminal

ArAE_2_N

Domain

3,788

false

This domain is found in proteins conserved in fungi. Their function is not known. This entry represents the N-terminal half of some member proteins which contain the DUF2421 domain ( ) at their C terminus. These proteins are putative endoplasmic reticulum tranpsorters, with a total of 12 TMs.

[]

0

[ "PFAM" ]

[ "PF10337" ]

[ "ArAE_2_N" ]

[ 3788 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3788 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Domain

Putative ER transporter, 6TM, N-terminal

ArAE_2_N

4

IPR018824

18,824

Conidiation-specific protein 6

Conidiation-specific_6

Family

1,933

false

This entry represents a conserved region found in fungal conidiation-specific protein 6 [ ]. This protein is expressed approximately 6 hours after the induction of development and is induced just prior to major constriction-chain growth [ ].

[]

0

[ "PFAM" ]

[ "PF10346" ]

[ "Con-6" ]

[ 1933 ]

1

[]

0

[]

0

[ "PUB00044205", "PUB00044206" ]

[ "8224542", "9560395" ]

[ "Structural characterization and expression analysis of the Neurospora conidiation gene con-6.", "The fluffy gene of Neurospora crassa encodes a Gal4p-type C6 zinc cluster protein required for conidial development." ]

[ 1993, 1998 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1933 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 3 ]

2

true

Family

Conidiation-specific protein 6

Conidiation-specific_6

7

IPR018825

18,825

Domain of unknown function DUF2427

DUF2427

Domain

3,698

false

This entry represents the N-terminal region of a family of proteins conserved in fungi. Several of these proteins are annotated as being Ftp1 but this could not be confirmed. Their function is not known.

[]

0

[ "PFAM" ]

[ "PF10348" ]

[ "DUF2427" ]

[ 3698 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Marinilactibacillus psychrotolerans" ]

[ 3697, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1, 1 ]

3

true

Domain

Domain of unknown function DUF2427

DUF2427

3

IPR018827

18,827

Protein YTP1-like, C-terminal

YTP1_C

Domain

3,550

false

This entry represents a conserved sequence region found a family of poorly characterised fungal proteins, including YTP1 from S. cerevisiae. It appears to contain regions similar to mitochondrial electron transport proteins. The C-terminal domain is hydrophobic and negatively charged. There are consensus sites for both...

[]

0

[ "PFAM" ]

[ "PF10355" ]

[ "Ytp1" ]

[ 3550 ]

1

[]

0

[]

0

[ "PUB00044557" ]

[ "8635735" ]

[ "Sequence of the Saccharomyces cerevisiae YTP1 gene encoding a deduced novel type-III integral membrane protein with domains of sequence similarity to mitochondrial electron-transport enzymes." ]

[ 1996 ]

1

[]

0

null

[ "Eukaryota", "Streptomyces polyasparticus" ]

[ 3549, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 1 ]

3

true

Domain

Protein YTP1-like, C-terminal

YTP1_C

8

IPR018828

18,828

Required for respiratory growth protein 7, mitochondrial

RRG7

Family

1,819

false

These family represents a group of mitochondrial fungal proteins, including RRG7, whose function is not yet known.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10356", "PTHR28133" ]

[ "RRG7", "" ]

[ 1606, 1763 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 1817, 2 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Required for respiratory growth protein 7, mitochondrial

RRG7

3

IPR018829

18,829

Domain of unknown function DUF2433

DUF2433

Domain

1,604

false

This entry represents a conserved domain of 120 residues from a family fungal proteins. Their function is not known.

[]

0

[ "PFAM" ]

[ "PF10360" ]

[ "DUF2433" ]

[ 1604 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 6, 1598 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

Domain of unknown function DUF2433

DUF2433

8