interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR021968 | 21,968 | Polyribonucleotide phosphorylase C-terminal | PNPase_C | Domain | 2,124 | false | false | PNPase regulates the expression of small non-coding RNAs that control expression of outer-membrane proteins. The enzyme also affects complex processes, such as the tissue-invasive virulence of Salmonella enterica and the regulation of a virulence-factor secretion system in Yersinia. In Escherichia coli, PNPase is invol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12111"
] | [
"PNPase_C"
] | [
2124
] | 1 | [] | [] | [] | 0 | [
"3gcm",
"3gme",
"3h1c",
"9ibh",
"9qh0"
] | 5 | [
"PUB00052156"
] | [
"19327365"
] | [
"Crystal structure of Escherichia coli polynucleotide phosphorylase core bound to RNase E, RNA and manganese: implications for catalytic mechanism and RNA degradosome assembly."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadota",
"marine sediment metagenome"
] | [
4,
2119,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Polyribonucleotide phosphorylase C-terminal | Polyribonucleotide phosphorylase C-terminal | PNPase_C | 4 |
IPR021969 | 21,969 | Protein of unknown function DUF3579 | DUF3579 | Family | 1,733 | false | false | This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 98 to 126 amino acids in length. This protein has a conserved FRP sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12112"
] | [
"DUF3579"
] | [
1733
] | 1 | [] | [] | [] | 0 | [
"2l9d"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1697,
3,
33
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3579 | Protein of unknown function DUF3579 | DUF3579 | 4 |
IPR021970 | 21,970 | Sequence-variable mosaic (SVM), signal sequence | SVM_signal | Domain | 405 | false | false | This domain is presumed to be a signal peptide sequence found in Sequence-variable mosaic (SVM) proteins [ ]. It is found in phytoplasmas. This presumed signal sequence is about 30 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12113"
] | [
"SVM_signal"
] | [
405
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053557"
] | [
"17688407"
] | [
"Sequence-variable mosaics: composites of recurrent transposition characterizing the genomes of phylogenetically diverse phytoplasmas."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Candidatus Phytoplasma"
] | [
405
] | 1 | [] | [] | 0 | true | Domain | Sequence-variable mosaic (SVM), signal sequence | Sequence-variable mosaic (SVM), signal sequence | SVM_signal | 3 |
IPR021971 | 21,971 | Salivary protein 15 | Salp15 | Family | 1,086 | false | false | This is a family of 15kDa salivary proteins (Salp15) from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation and interleukin (IL)-2 production [ , ]. It downregulat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12115"
] | [
"Salp15"
] | [
1086
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00069638",
"PUB00069639",
"PUB00101346",
"PUB00101347"
] | [
"12121666",
"20201978",
"17343683",
"17082567"
] | [
"Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.",
"Two novel Salp15-like immunosuppressant genes from salivary glands of Ixodes persulcatus Schulze tick.",
"T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15.",
"Cutting edge: CD4 is the receptor ... | [
2002,
2010,
2007,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Ixodoidea"
] | [
1086
] | 1 | [] | [] | 0 | true | Family | Salivary protein 15 | Salivary protein 15 | Salp15 | 3 |
IPR021972 | 21,972 | Parvovirus non-structural protein 1, C-terminal | Parvovirus_NS1_C | Domain | 364 | false | false | Parvoviruses are some of the smallest viruses containing linear, non-segmented single-stranded DNA genomes, with an average genome size of 5000 nucleotides. Parvoviruses have been described that infect a wide range of invertebrates and vertebrates and are well known for causing enteric disease in mammals. Genomes conta... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12117"
] | [
"NS1_C"
] | [
364
] | 1 | [
"EC",
"EC"
] | [
"3.1.21.-",
"3.6.4.12"
] | [
"EC:3.1.21.-",
"EC:3.6.4.12"
] | 2 | [] | 0 | [
"PUB00054921",
"PUB00083690",
"PUB00096849",
"PUB00096898"
] | [
"20097398",
"9847309",
"7799962",
"12050365"
] | [
"Determination and analysis of the full-length chicken parvovirus genome.",
"A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice.",
"Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1.",
... | [
2010,
1999,
1995,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Parvoviridae"
] | [
364
] | 1 | [] | [] | 0 | true | Domain | Parvovirus non-structural protein 1, C-terminal | Parvovirus non-structural protein 1, C-terminal | Parvovirus_NS1_C | 3 |
IPR021973 | 21,973 | SprA-related family | SprA-related | Family | 1,620 | false | false | This family of bacterial proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold [ ]. Proteins in this family are typically between 234 to 465 amino acids in length. Most members are annotated as being SprA-related. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12118"
] | [
"SprA-related"
] | [
1620
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075429"
] | [
"23671590"
] | [
"CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
1593,
27
] | 2 | [] | [] | 0 | true | Family | SprA-related family | SprA-related family | SprA-related | 7 |
IPR021974 | 21,974 | Protein of unknown function DUF3581 | DUF3581 | Family | 976 | false | false | This family consists of uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12119"
] | [
"DUF3581"
] | [
976
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
966,
10
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3581 | Protein of unknown function DUF3581 | DUF3581 | 9 |
IPR021975 | 21,975 | Rifampin ADP-ribosyltransferase | Rifampin_Arr | Domain | 2,371 | false | false | Arr enzymes catalyze ADP-ribosylation of rifamycins, thus rendering rifamycin antibiotics ineffective. The opportunistic pathogen Mycobacterium smegmatis possesses a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). An homologue of Arr, Arr-2, is present in several transposons and integrons found in Gram-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12120"
] | [
"Arr-ms"
] | [
2371
] | 1 | [] | [] | [] | 0 | [
"2hw2"
] | 1 | [
"PUB00047648"
] | [
"18349144"
] | [
"Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
2348,
3,
20
] | 3 | [] | [] | 0 | true | Domain | Rifampin ADP-ribosyltransferase | Rifampin ADP-ribosyltransferase | Rifampin_Arr | 3 |
IPR021976 | 21,976 | N-acetylmuramoyl-l-alanine amidase, C-terminal domain | Amidase_C | Domain | 559 | false | false | This domain is found in bacteria and viruses. This domain is about 50 amino acids in length. This domain is classified with the enzyme classification code . This domain is the C-terminal of the enzyme which hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptide... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12123"
] | [
"CBD_PlyG"
] | [
559
] | 1 | [] | [] | [] | 0 | [
"2l48"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
506,
53
] | 2 | [] | [] | 0 | true | Domain | N-acetylmuramoyl-l-alanine amidase, C-terminal domain | N-acetylmuramoyl-l-alanine amidase, C-terminal domain | Amidase_C | 6 |
IPR021977 | 21,977 | D domain of beta-TrCP | Beta-TrCP_D | Domain | 4,376 | false | false | This entry represents the D domain of beta-TrCP, which is a member of the WD40 class of F box proteins, and functions as a ubiquitin ligase. The D domain of these F box proteins is involved in mediating dimerisation of the protein [ ]. Dimerisation is necessary to polyubiquitinate substrates, so this D domain is vital ... | [
"GO:0046983"
] | [
"protein dimerization activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF12125",
"SM01028"
] | [
"Beta-TrCP_D",
"Beta-TrCP_D"
] | [
4359,
4342
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169091",
"R-HSA-1170546",
"R-HSA-174113",
"R-HSA-180534",
"R-HSA-195253",
"R-HSA-202424",
"R-HSA-2565942",
"R-HSA-2871837",
"R-HSA-3769402",
"R-HSA-5607761",
"R-HSA-5607764",
"R-HSA-5610780",
"R-HSA-5610783",
"R-HSA-5610785",
"R-HSA-5676590",
"R-HSA-5684264",
"R-HSA-69601",
... | [
"REACTOME:R-HSA-1169091",
"REACTOME:R-HSA-1170546",
"REACTOME:R-HSA-174113",
"REACTOME:R-HSA-180534",
"REACTOME:R-HSA-195253",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-2871837",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-5607761",
"REACTOME:R-HSA-5607764",
"REACTOME:R-... | 33 | [
"2p64",
"6ttu"
] | 2 | [
"PUB00048624"
] | [
"17574027"
] | [
"Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4376
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
7,
3,
10,
5,
20
] | 6 | true | Domain | D domain of beta-TrCP | D domain of beta-TrCP | Beta-TrCP_D | 6 |
IPR021978 | 21,978 | PML-like, coiled-coil | PML-like_CC | Domain | 1,378 | false | false | PML, also known as TRIM19, acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. It acts as the scaffold of PML-NBs allowing other proteins to... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12126"
] | [
"PML_CC"
] | [
1378
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-6804758",
"R-HSA-877300",
"R-HSA-8934593",
"R-HSA-8948747",
"R-HSA-9609690",
"R-HSA-9616222",
"R-MMU-3108214",
"R-MMU-3232142",
"R-MMU-6804758",
"R-MMU-8934593",
"R-MMU-8948747"
] | [
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-3232142",
"REACTOME:R-HSA-6804758",
"REACTOME:R-HSA-877300",
"REACTOME:R-HSA-8934593",
"REACTOME:R-HSA-8948747",
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9616222",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-3232142",
"REACTOME:R-MMU-6804758",
"REACTOME... | 13 | [
"4wjn",
"4wjo",
"6uyo",
"6uyp",
"6uyq",
"6uyr",
"6uys",
"6uyt",
"6uyu",
"6uyv",
"8dji"
] | 11 | [
"PUB00075437",
"PUB00102048"
] | [
"15356634",
"28250117"
] | [
"Cytoplasmic PML function in TGF-beta signalling.",
"The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus."
] | [
2004,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Sedimentitalea xiamensis"
] | [
1377,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
9,
7
] | 3 | true | Domain | PML-like, coiled-coil | PML-like, coiled-coil | PML-like_CC | 1 |
IPR021979 | 21,979 | Protein of unknown function DUF3584 | DUF3584 | Family | 997 | false | false | This family consist of uncharacterised bacterial and archaeal proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12128"
] | [
"DUF3584"
] | [
997
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Anopheles melas",
"Bacteria",
"Ignicoccus islandicus DSM 13165",
"metagenomes"
] | [
2,
985,
1,
9
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3584 | Protein of unknown function DUF3584 | DUF3584 | 8 |
IPR021980 | 21,980 | PHTF1/2, N-terminal | PHTF1/2_N | Domain | 3,155 | false | false | This domain is found in a group of homeodomain containing proteins from animals, including PHTF1/2, and is typically between 101 and 140 amino acids in length. PHTF proteins do not display any sequence similarity to known or predicted proteins, but their conservation among species suggests an essential function. The 84... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12129"
] | [
"PHTF1-2_N"
] | [
3155
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053558",
"PUB00053559"
] | [
"12604659",
"15601915"
] | [
"Phtf1 is an integral membrane protein localized in an endoplasmic reticulum domain in maturing male germ cells.",
"Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells."
] | [
2003,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3155
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
6,
13,
12
] | 5 | true | Domain | PHTF1/2, N-terminal | PHTF1/2, N-terminal | PHTF1/2_N | 5 |
IPR021981 | 21,981 | Domain of unknown function DUF3586 | DUF3586 | Domain | 277 | false | false | This domain is found in eukaryotes. This domain is about 80 amino acids in length and is found associated with , and . | [
"GO:0004197"
] | [
"cysteine-type endopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12131"
] | [
"DUF3586"
] | [
277
] | 1 | [
"EC"
] | [
"3.4.22.-"
] | [
"EC:3.4.22.-"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
277
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3586 | Domain of unknown function DUF3586 | DUF3586 | 5 |
IPR021982 | 21,982 | Repeat element protein, Ichnovirus | REEP_Ichnovirus | Family | 61 | false | false | This entry includes repeat element protein from Ichnovirus. Its function is not clear. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12132"
] | [
"DUF3587"
] | [
61
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Obtectomera",
"Viruses incertae sedis"
] | [
14,
47
] | 2 | [] | [] | 0 | true | Family | Repeat element protein, Ichnovirus | Repeat element protein, Ichnovirus | REEP_Ichnovirus | 5 |
IPR021983 | 21,983 | PRP8 domain IV core | PRP8_domainIV | Domain | 4,983 | false | false | This entry represents Prp8 domain IV, which adopts a RNase H like fold within its core structure but with little sequence similarity. Pre-mRNA-splicing factor 8 (Prp8), a spliceosome protein, interacts directly with the splice sites and branch regions of precursor-mRNAs and spliceosomal RNAs associated with catalysis o... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF12134",
"cd13838"
] | [
"PRP8_domainIV",
"RNase_H_like_Prp8_IV"
] | [
4982,
4530
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72163",
"R-CEL-72165",
"R-DDI-72163",
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165",
"R-SPO-72163"
] | [
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-72165",
"REACTOME:R-DDI-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165",
"REACTOME:R-SPO-72163"
] | 8 | [
"3e66",
"3e9l",
"3e9o",
"3e9p",
"3enb",
"3jb9",
"3jcm",
"3jcr",
"3lru",
"3sbg",
"3sbt",
"3zef",
"4i43",
"4ilg",
"4ilh",
"4ilj",
"4jk7",
"4jk8",
"4jk9",
"4jka",
"4jkb",
"4jkc",
"4jkd",
"4jke",
"4jkf",
"4jkg",
"4jkh",
"5gan",
"5gap",
"5gm6",
"5gmk",
"5lj3"... | 520 | [
"PUB00051743"
] | [
"18836455"
] | [
"Structural elucidation of a PRP8 core domain from the heart of the spliceosome."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4983
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
1,
2,
9,
1,
1,
8,
4,
1,
1,
31
] | 12 | true | Domain | PRP8 domain IV core | PRP8 domain IV core | PRP8_domainIV | 3 |
IPR021984 | 21,984 | Plasmodium repeat | Plasmodium_rpt | Repeat | 17 | false | false | This repeat is found in plasmodia. This entry contains two copies of the repeat. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12135"
] | [
"Plasmo_rep"
] | [
17
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Plasmodium (Vinckeia)"
] | [
17
] | 1 | [] | [] | 0 | true | Repeat | Plasmodium repeat | Plasmodium repeat | Plasmodium_rpt | 7 |
IPR021986 | 21,986 | Spherulation-specific family 4 | Spherulin4 | Family | 4,209 | false | false | This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length. There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the produc... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12138",
"PTHR35040"
] | [
"Spherulin4",
""
] | [
4200,
4063
] | 2 | [] | [] | [] | 0 | [
"5c5g",
"5d6t"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"ecological metagenomes"
] | [
14,
1904,
23,
2259,
9
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Spherulation-specific family 4 | Spherulation-specific family 4 | Spherulin4 | 6 |
IPR021988 | 21,988 | Beta-mannosyltransferase | BMT1 | Family | 577 | false | false | This entry represents a group of fungal beta-mannosyltransferase that is involved in cell wall biosynthesis [ , ]. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses onto cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-ma... | [
"GO:0000030"
] | [
"mannosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12141"
] | [
"BMT"
] | [
577
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [] | 0 | [
"PUB00075659",
"PUB00086020",
"PUB00097614",
"PUB00097617"
] | [
"24335083",
"18234669",
"21840970",
"22745283"
] | [
"Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.",
"Identification of a new family of genes involved in beta-1,2-mannosylation of glycans in Pichia pastoris and Candida albicans.",
"Elimination of β-mannose glycan structure... | [
2014,
2008,
2011,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
577
] | 1 | [] | [] | 0 | true | Family | Beta-mannosyltransferase | Beta-mannosyltransferase | BMT1 | 1 |
IPR021989 | 21,989 | Mediator complex, subunit Med12, catenin-binding | Mediator_Med12_catenin-bd | Domain | 2,297 | false | false | This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. It is found in the C-terminal region of the mediator of RNA polymerase II transcription subunit 12. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through ... | [
"GO:0008013",
"GO:0016592"
] | [
"beta-catenin binding",
"mediator complex"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF12144"
] | [
"Med12-PQL"
] | [
2297
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 5 | [
"8tq2",
"8tqc",
"8tqw"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Salmonella enterica subsp. enterica serovar Dessau",
"Vertebrata"
] | [
1,
2296
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
20,
7,
12
] | 4 | true | Domain | Mediator complex, subunit Med12, catenin-binding | Mediator complex, subunit Med12, catenin-binding | Mediator_Med12_catenin-bd | 8 |
IPR021991 | 21,991 | UHRF1, tandem tudor domain | TTD_dom | Domain | 2,794 | false | false | TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3) [ , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12148"
] | [
"TTD"
] | [
2794
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-HSA-3899300",
"R-HSA-5334118",
"R-HSA-9821002",
"R-MMU-3899300"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-HSA-3899300",
"REACTOME:R-HSA-5334118",
"REACTOME:R-HSA-9821002",
"REACTOME:R-MMU-3899300"
] | 6 | [
"2l3r",
"3ask",
"3db3",
"3db4",
"4gy5",
"4qqd",
"4tvr",
"5iay",
"5xpi",
"5yy9",
"5yya",
"6b9m",
"6ved",
"6vee",
"6vyj",
"6w92",
"7fb7",
"8xv4",
"8xv7"
] | 19 | [
"PUB00059694",
"PUB00069841",
"PUB00102988"
] | [
"21489993",
"14741369",
"23752590"
] | [
"Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.",
"NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.",
"Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenet... | [
2011,
2004,
2013
] | 3 | [] | [
"IPR047407"
] | 0 | 1 | 0 | [
"Metazoa"
] | [
2794
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
3,
7
] | 4 | true | Domain | UHRF1, tandem tudor domain | UHRF1, tandem tudor domain | TTD_dom | 1 |
IPR021992 | 21,992 | Mannan-binding protein | MVL | Domain | 447 | false | false | This domain family is found in bacteria, and is approximately 40 amino acids in length, There is a single completely conserved residue G that may be functionally important. The domain occurs in two types of proteins. In mannan binding proteins [ ], it forms a homodimeric molecule which complexes into a homo-octamer. In... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12151"
] | [
"MVL"
] | [
447
] | 1 | [] | [] | [] | 0 | [
"1zhq",
"1zhs"
] | 2 | [
"PUB00038895"
] | [
"15937331"
] | [
"Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: structural basis for specificity and high-affinity binding to the core pentasaccharide from n-linked oligomannoside."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Elysia marginata"
] | [
446,
1
] | 2 | [] | [] | 0 | true | Domain | Mannan-binding protein | Mannan-binding protein | MVL | 9 |
IPR021993 | 21,993 | Putative metal-binding domain of cation transport ATPase | ATPase-cat-bd | Domain | 5,986 | false | false | This domain is found in bacteria, and is approximately 90 amino acids in length. It is found associated with , , . The cysteine-rich nature and composition suggest this might be a cation-binding domain; most members are annotated as being cation transport ATPases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12156"
] | [
"ATPase-cat_bd"
] | [
5986
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Capitella teleta",
"Stygiolobus caldivivus",
"unclassified sequences"
] | [
5907,
1,
1,
77
] | 4 | [] | [] | 0 | true | Domain | Putative metal-binding domain of cation transport ATPase | Putative metal-binding domain of cation transport ATPase | ATPase-cat-bd | 6 |
IPR021995 | 21,995 | Protein of unknown function DUF3593 | DUF3593 | Family | 1,244 | false | false | This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 98 and 228 amino acids in length. There is a conserved LHG sequence motif. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12159",
"PTHR35473"
] | [
"DUF3593",
""
] | [
1244,
1092
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
411,
833
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
3,
14
] | 3 | true | Family | Protein of unknown function DUF3593 | Protein of unknown function DUF3593 | DUF3593 | 8 |
IPR021996 | 21,996 | Fibrinogen alpha C domain | Fibrinogen_aC | Domain | 324 | false | false | This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with . This domain is the C-terminal domain of fibrinogen in mammals. The domain lies in the C-terminal half of the alpha C region in these proteins. The function of the domain is that of int... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12160"
] | [
"Fibrinogen_aC"
] | [
324
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-114608",
"R-HSA-1236974",
"R-HSA-140875",
"R-HSA-166058",
"R-HSA-216083",
"R-HSA-354192",
"R-HSA-354194",
"R-HSA-372708",
"R-HSA-381426",
"R-HSA-5602498",
"R-HSA-5603041",
"R-HSA-5674135",
"R-HSA-5686938",
"R-HSA-6802946",
"R-HSA-6802948",
"R-HSA-6802952",
"R-HSA-6802955",
"... | [
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-354192",
"REACTOME:R-HSA-354194",
"REACTOME:R-HSA-372708",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-5602498",
"REACTOME:R-HSA-5603041",
"REACTOME:R-HSA-... | 41 | [
"1ei3",
"1m1j",
"2baf",
"2jor",
"3ghg"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Marinobacter xestospongiae"
] | [
323,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
7
] | 3 | true | Domain | Fibrinogen alpha C domain | Fibrinogen alpha C domain | Fibrinogen_aC | 7 |
IPR021997 | 21,997 | Stage V sporulation protein AA | SporV_AA | Domain | 1,691 | false | false | This domain family is found in bacteria - primarily Firmicutes, and is approximately 90 amino acids in length. There is a single completely conserved residue G that may be functionally important. Most annotation associated with this domain suggests that it is involved in the fifth stage of sporulation, however there is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12164"
] | [
"SporV_AA"
] | [
1691
] | 1 | [] | [] | [] | 0 | [
"3g74"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Phytophthora kernoviae 00238/432",
"bioreactor metagenome"
] | [
1689,
1,
1
] | 3 | [] | [] | 0 | true | Domain | Stage V sporulation protein AA | Stage V sporulation protein AA | SporV_AA | 7 |
IPR021998 | 21,998 | Alfin, N-terminal | Alfin_N | Domain | 5,483 | false | false | This entry represents the N-terminal domain found in Alfin family members. The Alfin family includes PHD finger protein Alfin1 and Alfin1-like proteins. They contain a conserved N domain at the N terminus, a PHD finger domain with conserved C4HC3 residues at the C terminus and a variable V region between the two conser... | [
"GO:0042393",
"GO:0006355"
] | [
"histone binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF12165"
] | [
"Alfin"
] | [
5483
] | 1 | [] | [] | [] | 0 | [
"5xvj",
"5xvl",
"5xvw",
"5y21",
"5y53"
] | 5 | [
"PUB00066381",
"PUB00066382",
"PUB00098042"
] | [
"10364398",
"10750899",
"29426828"
] | [
"Transgenic overexpression of the transcription factor alfin1 enhances expression of the endogenous MsPRP2 gene in alfalfa and improves salinity tolerance of the plants",
"Alfin1 transcription factor overexpression enhances plant root growth under normal and saline conditions and improves salt tolerance in alfalf... | [
1999,
2000,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Aphanizomenonaceae",
"Eukaryota"
] | [
4,
5479
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
17,
108
] | 3 | true | Domain | Alfin, N-terminal | Alfin, N-terminal | Alfin_N | 9 |
IPR022000 | 22,000 | Min27-like integrase, DNA-binding domain | Min27-like_integrase_DNA_bind | Domain | 3,366 | false | false | This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with . It is likely that this domain acts to bind DNA. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12167"
] | [
"Arm-DNA-bind_2"
] | [
3366
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
3273,
2,
60,
31
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Min27-like integrase, DNA-binding domain | Min27-like integrase, DNA-binding domain | Min27-like_integrase_DNA_bind | 6 |
IPR022001 | 22,001 | DNA polymerase III subunit tau, DnaB-binding domain IV | DNA_pol3_tau_IV | Domain | 1,840 | false | false | This domain found in bacterial proteins, and is approximately 80 amino acids in length. It is found in association with . domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding domain IV and all of the alpha-interacting domain V are unique to tau. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12168"
] | [
"DNA_pol3_tau_4"
] | [
1840
] | 1 | [] | [] | [] | 0 | [
"8gj0",
"8gj1",
"8gj2",
"8gj3"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"human gut metagenome"
] | [
1836,
3,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA polymerase III subunit tau, DnaB-binding domain IV | DNA polymerase III subunit tau, DnaB-binding domain IV | DNA_pol3_tau_IV | 4 |
IPR022002 | 22,002 | ChsH2, rubredoxin-like zinc ribbon domain | ChsH2_Znr | Domain | 15,373 | false | false | This domain is found in the probable enoyl-CoA hydratase alpha subunit from Thermomonospora curvata (ChsH2) and similar archaeal and bacterial proteins. ChsH2 is likely to be involved in bile acid degradation. The C-terminal region of this protein is organised into two domains: an N-terminal zinc finger domain with a t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12172"
] | [
"zf-ChsH2"
] | [
15373
] | 1 | [] | [] | [] | 0 | [
"3irb",
"5m3k",
"5mg5",
"6esq",
"6et9",
"6htj",
"6ok1",
"7pxp",
"7pyt",
"7yxm",
"9myr"
] | 11 | [
"PUB00097287",
"PUB00154878",
"PUB00155451",
"PUB00155452"
] | [
"20944206",
"29531083",
"31209106",
"35313080"
] | [
"The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.",
"Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.",
"The steroid sid... | [
2010,
2018,
2019,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1585,
13347,
13,
428
] | 4 | [] | [] | 0 | true | Domain | ChsH2, rubredoxin-like zinc ribbon domain | ChsH2, rubredoxin-like zinc ribbon domain | ChsH2_Znr | 3 |
IPR022004 | 22,004 | White spot syndrome virus structural envelope protein Vp28 | WSSV_Vp28 | Domain | 147 | false | false | This family of proteins is found in viruses. Proteins in this family are approximately 210 amino acids in length. There is a conserved NNT sequence motif. These proteins are structural envelope proteins in viruses. This is the β barrel C-terminal domain. There is a protruding N-terminal domain which completes the prote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12175"
] | [
"WSS_VP"
] | [
147
] | 1 | [] | [] | [] | 0 | [
"2ed6",
"2edm",
"5hlj"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nimaviridae",
"Paenibacillus illinoisensis"
] | [
146,
1
] | 2 | [] | [] | 0 | true | Domain | White spot syndrome virus structural envelope protein Vp28 | White spot syndrome virus structural envelope protein Vp28 | WSSV_Vp28 | 4 |
IPR022005 | 22,005 | Prohormone convertase enzyme | Proho_convert | Domain | 1,036 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with , . There are two completely conserved residues (Y and D) that may be functionally important. This protein is the C-terminal domain of a prohormone convertase enzyme which targets hormones i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12177"
] | [
"Proho_convert"
] | [
1036
] | 1 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.93",
"GenProp2086",
"GenProp2087",
"R-HSA-209952",
"R-HSA-264876",
"R-HSA-381771",
"R-HSA-400511",
"R-HSA-422085",
"R-MMU-209952",
"R-MMU-422085",
"R-RNO-209952",
"R-RNO-422085"
] | [
"EC:3.4.21.93",
"GP:GenProp2086",
"GP:GenProp2087",
"REACTOME:R-HSA-209952",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-381771",
"REACTOME:R-HSA-400511",
"REACTOME:R-HSA-422085",
"REACTOME:R-MMU-209952",
"REACTOME:R-MMU-422085",
"REACTOME:R-RNO-209952",
"REACTOME:R-RNO-422085"
] | 12 | [
"2kdt",
"2ke3"
] | 2 | [
"PUB00048324"
] | [
"19376969"
] | [
"Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1036
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2,
3
] | 4 | true | Domain | Prohormone convertase enzyme | Prohormone convertase enzyme | Proho_convert | 7 |
IPR022006 | 22,006 | Chromosome passenger complex (CPC) protein INCENP N-terminal | INCENP_N | Domain | 1,053 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12178"
] | [
"INCENP_N"
] | [
1053
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-4615885",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-4615885",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025",
"R-XTR-141444",
"R-XTR-2467813",
"R-XTR-2500257",
... | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-4615885",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-4615885",
"REACTOME:R-... | 21 | [
"2qfa",
"6yie",
"6yif",
"6yih",
"8rup",
"9si3",
"9si9",
"9sj5",
"9slj"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1053
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
5
] | 4 | true | Domain | Chromosome passenger complex (CPC) protein INCENP N-terminal | Chromosome passenger complex (CPC) protein INCENP N-terminal | INCENP_N | 2 |
IPR022007 | 22,007 | I-kappa-kinase-beta NEMO binding domain | IKKbetaNEMObind | Domain | 1,791 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with . These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokine... | [
"GO:0008384"
] | [
"IkappaB kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF12179",
"SM01239"
] | [
"IKKbetaNEMObind",
"IKKbetaNEMObind"
] | [
1779,
1744
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.10",
"R-BTA-1169091",
"R-BTA-1810476",
"R-BTA-202424",
"R-BTA-209543",
"R-BTA-209560",
"R-BTA-2871837",
"R-BTA-445989",
"R-BTA-5357905",
"R-BTA-5357956",
"R-BTA-5607761",
"R-BTA-5607764",
"R-BTA-5676590",
"R-BTA-5684264",
"R-BTA-9020702",
"R-BTA-933542",
"R-BTA-937039",
"R-... | [
"EC:2.7.11.10",
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1810476",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-209543",
"REACTOME:R-BTA-209560",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-445989",
"REACTOME:R-BTA-5357905",
"REACTOME:R-BTA-5357956",
"REACTOME:R-BTA-5607761",
"REACTOME:R-BTA-560776... | 106 | [
"3brt",
"3brv"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1791
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
9,
8
] | 4 | true | Domain | I-kappa-kinase-beta NEMO binding domain | I-kappa-kinase-beta NEMO binding domain | IKKbetaNEMObind | 6 |
IPR022008 | 22,008 | TSG101 and ALIX binding domain of CEP55 | EABR | Domain | 1,801 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich seq... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12180"
] | [
"EABR"
] | [
1801
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5684264",
"R-HSA-5689896",
"R-MMU-5684264",
"R-MMU-5689896"
] | [
"REACTOME:R-HSA-5684264",
"REACTOME:R-HSA-5689896",
"REACTOME:R-MMU-5684264",
"REACTOME:R-MMU-5689896"
] | 4 | [
"3e1r",
"3wut",
"3wuu",
"3wuv",
"9p3y"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1801
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3,
5
] | 4 | true | Domain | TSG101 and ALIX binding domain of CEP55 | TSG101 and ALIX binding domain of CEP55 | EABR | 6 |
IPR022009 | 22,009 | Restriction endonuclease, type II, NotI | Resctriction_endonuc_II_NotI | Family | 274 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 270 and 341 amino acids in length. There is a conserved CPF sequence motif. The type IIP restriction enzyme, NotI , is a homodimer that recognises the 8 bp DNA sequence 5'-GC/GGCCGC-3' and cleaves both strands of DNA to create 5... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12183"
] | [
"NotI"
] | [
274
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
267,
3,
4
] | 3 | [] | [] | 0 | true | Family | Restriction endonuclease, type II, NotI | Restriction endonuclease, type II, NotI | Resctriction_endonuc_II_NotI | 7 |
IPR022011 | 22,011 | Nup358/RanBP2 E3 ligase domain | IR1-M | Domain | 1,424 | false | false | This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with , , . There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12185"
] | [
"IR1-M"
] | [
1424
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"2.3.2.-",
"PWY-6289",
"PWY-6462",
"PWY-6463",
"PWY-6682",
"PWY-6841",
"PWY-7815",
"PWY-7816",
"PWY-7817",
"PWY-7818",
"PWY-7887",
"R-HSA-1169408",
"R-HSA-141444",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
... | [
"EC:2.3.2.-",
"METACYC:PWY-6289",
"METACYC:PWY-6462",
"METACYC:PWY-6463",
"METACYC:PWY-6682",
"METACYC:PWY-6841",
"METACYC:PWY-7815",
"METACYC:PWY-7816",
"METACYC:PWY-7817",
"METACYC:PWY-7818",
"METACYC:PWY-7887",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-159227",
... | 67 | [
"1z5s",
"3uin",
"3uio",
"3uip",
"6lk8",
"7fik",
"7fil",
"7r5j",
"7r5k",
"7tdz",
"7vop",
"9b62"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1424
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
1,
4
] | 4 | true | Domain | Nup358/RanBP2 E3 ligase domain | Nup358/RanBP2 E3 ligase domain | IR1-M | 3 |
IPR022012 | 22,012 | D212, catalytic domain | D212_cat_dom | Domain | 29 | false | false | This family of proteins represented by Sulfolobus spindle-shaped virus (Ragged Hills) ORF D212; the structure of which has been reported [ ]. The structure of D212 clearly reveals a type II restriction endonuclease fold and identifies the hallmark PD-(D/E)XK catalytic motif that is spatially conserved in this nuclease ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12187"
] | [
"VirArc_Nuclease"
] | [
29
] | 1 | [] | [] | [] | 0 | [
"2w8m"
] | 1 | [
"PUB00054410"
] | [
"20375162"
] | [
"The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Fuselloviridae",
"Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)",
"Thermoprotei",
"viral metagenome"
] | [
2,
6,
1,
19,
1
] | 5 | [] | [] | 0 | true | Domain | D212, catalytic domain | D212, catalytic domain | D212_cat_dom | 7 |
IPR022013 | 22,013 | Fungal calcium binding protein | CBP | Domain | 217 | false | false | This domain is found in eukaryotes, and is approximately 60 amino acids in length. There is a single completely conserved residue C that may be functionally important. This is a calcium binding domain from the fungal protein CBP (calcium binding protein). This protein is a virulence factor with unknown virulence mechan... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12192"
] | [
"CBP"
] | [
217
] | 1 | [] | [] | [] | 0 | [
"2jv7",
"7r6u",
"7r79"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
217
] | 1 | [] | [] | 0 | true | Domain | Fungal calcium binding protein | Fungal calcium binding protein | CBP | 5 |
IPR022015 | 22,015 | Tuberculin-active protein | Tuberculin | Domain | 1 | false | false | This entry represents a domain found in the tuberculin-active protein from Mycobacterium tuberculosis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12198"
] | [
"Tuberculin"
] | [
1
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098609"
] | [
"804477"
] | [
"Amino acid sequence of tuberculin-active protein from Mycobacterium tuberculosis."
] | [
1975
] | 1 | [] | [] | 0 | 0 | null | [
"Mycobacterium tuberculosis"
] | [
1
] | 1 | [] | [] | 0 | true | Domain | Tuberculin-active protein | Tuberculin-active protein | Tuberculin | 4 |
IPR022016 | 22,016 | Domain of unknown function DUF3597 | DUF3597 | Domain | 1,956 | false | false | The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two. It is found in proteins from bacteria, eukaryotes and viruses. The function of this domain is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12200"
] | [
"DUF3597"
] | [
1956
] | 1 | [] | [] | [] | 0 | [
"2gqb"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
1860,
9,
79,
8
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3597 | Domain of unknown function DUF3597 | DUF3597 | 1 |
IPR022017 | 22,017 | Biogenesis factor required for ATP synthase 1-like, DUF3598 | BFA1-like_DUF3598 | Domain | 1,197 | false | false | This entry represents a domain predominantly found in proteins from cyanobacteria and plants, including Biogenesis factor required for ATP synthase 1 (BFA1, ) from Arabidopsis thaliana and other uncharacterised proteins. BFA1 promotes the assembly of the CF1 subcomplex of the chloroplast ATP synthase by specifically in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12204"
] | [
"DUF3598_N"
] | [
1197
] | 1 | [] | [] | [] | 0 | [
"2o62",
"5yvf"
] | 2 | [
"PUB00100989"
] | [
"30012777"
] | [
"Nucleus-Encoded Protein BFA1 Promotes Efficient Assembly of the Chloroplast ATP Synthase Coupling Factor 1."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
573,
622,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
4,
9
] | 3 | true | Domain | Biogenesis factor required for ATP synthase 1-like, DUF3598 | Biogenesis factor required for ATP synthase 1-like, DUF3598 | BFA1-like_DUF3598 | 7 |
IPR022018 | 22,018 | ARF GTPase-activating protein GIT1, C-terminal | GIT1_C | Domain | 6,477 | false | false | This entry represents the C-terminal domain of the ARF GTPase-activating protein GIT1. GIT1 is an ArfGAP and scaffolding protein regulating cell adhesion and migration [ ]. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12205"
] | [
"GIT1_C"
] | [
6477
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-3928664",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013406",
"R-DME-9013420",
"R-DME-9013423",
"R-DME-9013424",
"R-HSA-3928664",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013406",
"R-HSA-9013409",
"R-HSA-9013420",
"R-HSA-9013423",
"R-HSA-9013424",
"R-HSA-96192... | [
"REACTOME:R-DME-3928664",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013404",
"REACTOME:R-DME-9013406",
"REACTOME:R-DME-9013420",
"REACTOME:R-DME-9013423",
"REACTOME:R-DME-9013424",
"REACTOME:R-HSA-3928664",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOM... | 30 | [
"2jx0",
"6iuh",
"6iui",
"6jmu"
] | 4 | [
"PUB00075464"
] | [
"24699139"
] | [
"Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nitrososphaerota"
] | [
6475,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
13,
1,
13,
11,
1,
12,
1
] | 8 | true | Domain | ARF GTPase-activating protein GIT1, C-terminal | ARF GTPase-activating protein GIT1, C-terminal | GIT1_C | 1 |
IPR022019 | 22,019 | Domain of unknown function DUF3600 | DUF3600 | Domain | 370 | false | false | This domain is found at the C terminus of the putative ECF-type sigma factor negative effector. Proteins in this entry are approximately 230 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12207"
] | [
"DUF3600"
] | [
370
] | 1 | [] | [] | [] | 0 | [
"3fgg",
"3fh3"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales",
"Physcomitrium patens"
] | [
369,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3600 | Domain of unknown function DUF3600 | DUF3600 | 9 |
IPR022020 | 22,020 | Domain of unknown function DUF3601 | DUF3601 | Domain | 135 | false | false | This domain family is found in bacteria, and is approximately 80 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12208"
] | [
"DUF3601"
] | [
135
] | 1 | [] | [] | [] | 0 | [
"3g1j"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
135
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3601 | Domain of unknown function DUF3601 | DUF3601 | 5 |
IPR022022 | 22,022 | Immune evasion protein | M04gp34-like | Family | 196 | false | false | The proteins in this family are related to the m04 encoded protein gp34 of pathogenic microorganisms such as Murid herpesvirus 1. m06 and m152 genes are expressed earlier in the intracellular replication phases of these microorganism' life cycles. They function to inhibit MHC-1 loading and export. gp34 is theorized to ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12216"
] | [
"m04gp34like"
] | [
196
] | 1 | [] | [] | [] | 0 | [
"2miz",
"4pn6",
"5tzn"
] | 3 | [
"PUB00088238"
] | [
"10644360"
] | [
"The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Muromegalovirus muridbeta1"
] | [
196
] | 1 | [] | [] | 0 | true | Family | Immune evasion protein | Immune evasion protein | M04gp34-like | 8 |
IPR022023 | 22,023 | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | U1snRNP70_N | Domain | 4,195 | false | false | This domain is about 90 amino acids in length and is found at the N terminus of U1 small nuclear ribonucleoprotein 70kDa (U1-70K), which is part of the U1 snRNP (snRNP) complex. U1 snRNP recognises the 5' splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision. The N... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12220"
] | [
"U1snRNP70_N"
] | [
4195
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163"
] | 2 | [
"3cw1",
"3pgw",
"4pjo",
"4pkd",
"5zwn",
"6g90",
"6n7p",
"6n7r",
"6n7x",
"6qx9",
"7b0y",
"7oqc",
"7oqe",
"7vpx",
"8r08",
"8w2o",
"9qeq"
] | 17 | [
"PUB00051148"
] | [
"19325628"
] | [
"Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paraburkholderia bryophila"
] | [
4194,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
2,
3,
9,
1,
6,
5,
1,
1,
6
] | 12 | true | Domain | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | U1snRNP70_N | 4 |
IPR022024 | 22,024 | Protein of unknown function DUF3602 | DUF3602 | Family | 4,082 | false | false | This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length. This entry include protein Par32 from Saccharomyces cerevisiae. Par32 is hyperphosphorylated after treatment with rapamycin in a TAP42-dependent manner [ ]. It is also involved in resistance to cisplatin [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12223"
] | [
"DUF3602"
] | [
4082
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066962",
"PUB00066963"
] | [
"19684113",
"15994967"
] | [
"Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.",
"Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae."
] | [
2009,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
4081,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
1
] | 2 | true | Family | Protein of unknown function DUF3602 | Protein of unknown function DUF3602 | DUF3602 | 6 |
IPR022026 | 22,026 | Methylene-tetrahydrofolate reductase-like, C-terminal domain | DUF5981 | Domain | 1,974 | false | false | This entry represents a domain of unknown function, which contains 8 conserved cysteine residues that might form a metal binding site. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12225"
] | [
"DUF5981"
] | [
1974
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caenorhabditis remanei",
"ecological metagenomes"
] | [
114,
1723,
1,
136
] | 4 | [] | [] | 0 | true | Domain | Methylene-tetrahydrofolate reductase-like, C-terminal domain | Methylene-tetrahydrofolate reductase-like, C-terminal domain | DUF5981 | 4 |
IPR022027 | 22,027 | Turkey astrovirus capsid protein | Astro_capsid_p | Family | 432 | false | false | This family of proteins is found in viruses. Proteins in this family are typically between 241 and 261 amino acids in length. These proteins are capsid proteins from various astrovirus strains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12226"
] | [
"Astro_capsid_p"
] | [
432
] | 1 | [] | [] | [] | 0 | [
"3qsq",
"5ewo",
"5kou",
"5kov",
"5w1n",
"7rk1",
"7rk2",
"7xca",
"9cbn",
"9cn2",
"9dbt"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Orthornavirae"
] | [
4,
428
] | 2 | [] | [] | 0 | true | Family | Turkey astrovirus capsid protein | Turkey astrovirus capsid protein | Astro_capsid_p | 8 |
IPR022028 | 22,028 | Protein of unknown function DUF3604 | DUF3604 | Family | 1,964 | false | false | This family of is found mainly in proteobacteria, their function is unknown | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12228"
] | [
"DUF3604"
] | [
1964
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
1763,
20,
36,
145
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3604 | Protein of unknown function DUF3604 | DUF3604 | 9 |
IPR022029 | 22,029 | YoaR-like, putative peptidoglycan binding domain | YoaR-like_PG-bd | Domain | 8,070 | false | false | This domain is found associated with the L,D-transpeptidase domain in the uncharacterised protein YoaR from Bacillus subtilis and similar bacterial proteins. The structure of this domain has been solved and shows a mixed α-β fold composed of nine β strands and four α helices. This domain is usually found to be duplicat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12229"
] | [
"PG_binding_4"
] | [
8070
] | 1 | [] | [] | [] | 0 | [
"1zat",
"2hkl",
"6fj1"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Acrobeloides nanus",
"Bacteria",
"Siphoviridae sp. ctsfh5",
"unclassified sequences"
] | [
1,
7964,
1,
104
] | 4 | [] | [] | 0 | true | Domain | YoaR-like, putative peptidoglycan binding domain | YoaR-like, putative peptidoglycan binding domain | YoaR-like_PG-bd | 5 |
IPR022030 | 22,030 | Splicing factor 3A subunit 1, conserved domain | SF3A1_dom | Domain | 4,722 | false | false | This domain is found in eukaryotes, and is typically between 212 and 238 amino acids in length. It is found in association with . There are two completely conserved residues (W and H) that may be functionally important. It is found in the subunit 1 of mammalian splicing factor SF3A, which is involved in converting the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12230"
] | [
"PRP21_like_P"
] | [
4722
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-HSA-72163",
"R-MMU-72163"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163"
] | 3 | [
"5nrl",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ff7",
"6g90",
"6qx9",
"6y53",
"6y5q",
"7abg",
"7abi",
"7dco",
"7evo",
"7oqb",
"7oqe",
"7vpx",
"8ch6",
"8h6e",
"8h6j",
"8h6k",
"8h6l",
"8hk1",
"8i0p",
"8i0r",
"8i0s",
"8i0t",
"8q7n",
"8qo9"... | 46 | [
"PUB00075579"
] | [
"7489498"
] | [
"Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4722
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
4,
1,
3,
2,
1,
3,
2,
1,
1,
7
] | 12 | true | Domain | Splicing factor 3A subunit 1, conserved domain | Splicing factor 3A subunit 1, conserved domain | SF3A1_dom | 8 |
IPR022031 | 22,031 | Telomere-associated protein Rif1, N-terminal | Rif1_N | Domain | 3,541 | false | false | This domain is found in N-terminal of the telomere-associated protein,Rif1. In budding yeast, Rif1 is Recruited to telomeres by interaction with the C terminus of RAP1 is recruited to telomeres by interaction with the C terminus of RAP1 and negatively regulates telomere length by preventing telomere elongation or promo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12231"
] | [
"Rif1_N"
] | [
3541
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5693571",
"R-MMU-5693571"
] | [
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-5693571"
] | 2 | [
"5nvr",
"5nw5"
] | 2 | [
"PUB00057836",
"PUB00066791",
"PUB00066792"
] | [
"15342490",
"1577274",
"9087429"
] | [
"Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.",
"A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.",
"A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere le... | [
2004,
1992,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3541
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe ... | [
4,
1,
4,
2,
1,
3,
4,
1,
1,
8
] | 10 | true | Domain | Telomere-associated protein Rif1, N-terminal | Telomere-associated protein Rif1, N-terminal | Rif1_N | 1 |
IPR022032 | 22,032 | Myogenic determination factor 5 | Myf5 | Domain | 1,900 | false | false | This domain is found in eukaryotes, is approximately 70 amino acids in length, and contains a conserved CSD sequence motif. It is found in association with , . This domain is found in Myogenic factor 5 (Myf5) and Myoblast determination protein 1 (MyoD1). Myf5 is responsible for directing cells to the skeletal myocyte l... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12232"
] | [
"Myf5"
] | [
1900
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-525793",
"R-DRE-525793",
"R-HSA-525793",
"R-HSA-9839394",
"R-MMU-525793",
"R-RNO-525793"
] | [
"REACTOME:R-BTA-525793",
"REACTOME:R-DRE-525793",
"REACTOME:R-HSA-525793",
"REACTOME:R-HSA-9839394",
"REACTOME:R-MMU-525793",
"REACTOME:R-RNO-525793"
] | 6 | [] | 0 | [
"PUB00075517",
"PUB00075518"
] | [
"17395511",
"21798092"
] | [
"Molecular cloning and characterization of the Myf5 gene in sea perch (Lateolabrax japonicus).",
"Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes."
] | [
2007,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1900
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
4,
5
] | 4 | true | Domain | Myogenic determination factor 5 | Myogenic determination factor 5 | Myf5 | 9 |
IPR022033 | 22,033 | RAVE complex protein Rav1 C-terminal | Rav1p_C | Domain | 7,394 | false | false | This domain family is found in the C-terminal region of the protein Rav1 [ ], a component of the RAVE (regulator of the ATPase of vacuolar and endosomal membranes) complex. Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12234"
] | [
"Rav1p_C"
] | [
7394
] | 1 | [] | [] | [] | 0 | [
"9cop"
] | 1 | [
"PUB00057224",
"PUB00057225"
] | [
"15090613",
"11844802"
] | [
"Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins.",
"The RAVE complex is essential for stable assembly of the yeast V-ATPase."
] | [
2004,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7394
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
8,
8,
2,
6,
6,
1,
3,
10,
1,
1,
23
] | 12 | true | Domain | RAVE complex protein Rav1 C-terminal | RAVE complex protein Rav1 C-terminal | Rav1p_C | 1 |
IPR022034 | 22,034 | Fragile X messenger ribonucleoprotein 1-like, C-terminal core | FMR1-like_C_core | Domain | 5,131 | false | false | This entry represents the core C-terminal region of the fragile X messenger ribonucleoprotein 1 (FMR1) and its paralogues fragile X-related proteins 1/2 (FXR1/2). These proteins have different regions at their very C terminus. The Glutamine-arginine rich region facilitates protein interactions [ , ]. Proteins containin... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12235"
] | [
"FXMRP1_C_core"
] | [
5131
] | 1 | [
"REACTOME"
] | [
"R-HSA-6802952"
] | [
"REACTOME:R-HSA-6802952"
] | 1 | [] | 0 | [
"PUB00054919",
"PUB00075713",
"PUB00075714",
"PUB00090595",
"PUB00090596",
"PUB00091337"
] | [
"16000371",
"20463240",
"16707258",
"28960184",
"29713264",
"25464849"
] | [
"The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.",
"Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein.",
"mRNPs, polysomes or granules: FMRP in neuronal protein synthesis.",
"Fragile X syndrome.",
"Modeling Fr... | [
2005,
2010,
2006,
2017,
2018,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
5131
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
6,
36,
15,
22
] | 5 | true | Domain | Fragile X messenger ribonucleoprotein 1-like, C-terminal core | Fragile X messenger ribonucleoprotein 1-like, C-terminal core | FMR1-like_C_core | 4 |
IPR022035 | 22,035 | PCIF1, WW domain | PCIF1_WW | Domain | 2,479 | false | false | This domain is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. It is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12237"
] | [
"PCIF1_WW"
] | [
2479
] | 1 | [
"EC"
] | [
"2.1.1.62"
] | [
"EC:2.1.1.62"
] | 1 | [
"6irv",
"6irw",
"6irx",
"6iry",
"6irz",
"6is0"
] | 6 | [
"PUB00092434"
] | [
"30467178"
] | [
"Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavobacteriales",
"Viruses",
"metagenomes"
] | [
2437,
9,
12,
21
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
3,
3
] | 5 | true | Domain | PCIF1, WW domain | PCIF1, WW domain | PCIF1_WW | 8 |
IPR022036 | 22,036 | Protein of unknown function DUF3605 | DUF3605 | Family | 3,095 | false | false | This family of proteins is found mostly in fungi, including N-acetylglucosamine-induced protein 1 (Gig1) from Candida albicans. Gig1 plays a role in the N-acetylglucosamine metabolic pathway [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12239",
"PTHR35020"
] | [
"DUF3605",
""
] | [
3038,
2979
] | 2 | [] | [] | [] | 0 | [
"5kci"
] | 1 | [
"PUB00086021"
] | [
"20675577"
] | [
"Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Endozoicomonadaceae",
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
4,
3076,
11,
4
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
1
] | 2 | true | Family | Protein of unknown function DUF3605 | Protein of unknown function DUF3605 | DUF3605 | 5 |
IPR022037 | 22,037 | Protein of unknown function DUF3606 | DUF3606 | Family | 2,492 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 85 amino acids in length. There is a single completely conserved residue G that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12244"
] | [
"DUF3606"
] | [
2492
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
2488,
2,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3606 | Protein of unknown function DUF3606 | DUF3606 | 9 |
IPR022038 | 22,038 | Ig-like domain, bacterial type | Ig-like_bact | Domain | 7,095 | false | false | This entry represents a domain with an Ig-like fold, found in a variety of bacterial surface proteins. | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PFAM"
] | [
"PF07523",
"PF12245",
"PF13750",
"PF13754"
] | [
"Big_3",
"Big_3_2",
"Big_3_3",
"Big_3_4"
] | [
2864,
3545,
1556,
61
] | 4 | [] | [] | [] | 0 | [
"2l7y",
"4fd0",
"4fdw",
"8c8g"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
65,
6928,
48,
20,
34
] | 5 | [] | [] | 0 | true | Domain | Ig-like domain, bacterial type | Ig-like domain, bacterial type | Ig-like_bact | 1 |
IPR022039 | 22,039 | Post-transcriptional regulator MKT1, C-terminal | MKT1_C | Domain | 1,791 | false | false | Mkt1 interacts with the Poly(A)-binding protein associated factor, Pbp1, and is present at the 3' end of RNA transcripts during translation. The Mkt1-Pbp1 complex is involved in the post-transcriptional regulation of HO endonuclease expression [ ]. In trypanosome, zinc finger protein ZC3H11 interacts with MKT1 and PBP1... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12246"
] | [
"MKT1_C"
] | [
1791
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00086748",
"PUB00093882"
] | [
"15082763",
"24470144"
] | [
"Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.",
"Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks."
] | [
2004,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1791
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Post-transcriptional regulator MKT1, C-terminal | Post-transcriptional regulator MKT1, C-terminal | MKT1_C | 1 |
IPR022040 | 22,040 | Post-transcriptional regulator MKT1, N-terminal | MKT1_N | Domain | 1,718 | false | false | Mkt1 interacts with the Poly(A)-binding protein associated factor, Pbp1, and is present at the 3' end of RNA transcripts during translation. The Mkt1-Pbp1 complex is involved in the post-transcriptional regulation of HO endonuclease expression [ ]. In trypanosome, zinc finger protein ZC3H11 interacts with MKT1 and PBP1... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12247"
] | [
"MKT1_N"
] | [
1718
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00086748",
"PUB00093882"
] | [
"15082763",
"24470144"
] | [
"Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.",
"Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks."
] | [
2004,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1718
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Post-transcriptional regulator MKT1, N-terminal | Post-transcriptional regulator MKT1, N-terminal | MKT1_N | 8 |
IPR022041 | 22,041 | Farnesoic acid O-methyl transferase | Methyltransf_FA | Domain | 4,438 | false | false | This domain, found in farnesoic acid O-methyl transferase, is approximately 110 amino acids in length. Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyses the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12248"
] | [
"Methyltransf_FA"
] | [
4438
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056185"
] | [
"18076110"
] | [
"Farnesoic acid O-methyl transferase (FAMeT) isoforms: conserved traits and gene expression patterns related to caste differentiation in the stingless bee, Melipona scutellaris."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
98,
4336,
4
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
3,
6,
2,
4,
3
] | 6 | true | Domain | Farnesoic acid O-methyl transferase | Farnesoic acid O-methyl transferase | Methyltransf_FA | 5 |
IPR022042 | 22,042 | snRNA-activating protein complex, subunit 3 | snRNA-activating_su3 | Family | 3,318 | false | false | snRNA-activating protein complex 50kDa subunit (SNAP50), also known as subunit 3, is part of the snRNA-activating protein complex which activates RNA polymerases II and III [ ]. It contains a cysteine-histidine cluster with two possible zinc finger motifs. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12251",
"PTHR13421"
] | [
"SNAPC3",
""
] | [
3266,
3204
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6807505",
"R-HSA-749476",
"R-HSA-76071",
"R-MMU-6807505",
"R-MMU-76071",
"R-RNO-6807505",
"R-RNO-76071"
] | [
"REACTOME:R-HSA-6807505",
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76071",
"REACTOME:R-MMU-6807505",
"REACTOME:R-MMU-76071",
"REACTOME:R-RNO-6807505",
"REACTOME:R-RNO-76071"
] | 7 | [
"7xur",
"7zwc",
"7zwd",
"7zx7",
"7zx8",
"7zxe",
"8ity",
"8iue",
"8iuh",
"9fso",
"9fsp",
"9fsq",
"9fsr",
"9fss",
"9k3b",
"9k3u",
"9k3v",
"9lxn"
] | 18 | [
"PUB00057222"
] | [
"9003788"
] | [
"Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paenibacillus silvae"
] | [
3317,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
4,
2,
2,
4,
2,
5,
3,
8
] | 9 | true | Family | snRNA-activating protein complex, subunit 3 | snRNA-activating protein complex, subunit 3 | snRNA-activating_su3 | 5 |
IPR022043 | 22,043 | Chromatin assembly factor 1 subunit A, dimerization domain | CAF1A_DD | Domain | 4,536 | false | false | The CAF-1 or chromatin assembly factor-1 consists of three subunits, p150, p60 and p48 and this entry includes the largest, p150 or A [ ]. Subunit p150 is uniquely required for the progression of S phase in mouse cells [ ], independent of its ability to promote histone deposition [ ] but dependent on its ability to int... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12253"
] | [
"CAF1A_dimeriz"
] | [
4536
] | 1 | [] | [] | [] | 0 | [
"7y5k",
"7y5l",
"7y5o",
"7y5u",
"7y5v",
"7y60",
"7y61",
"8iqf",
"8iqg",
"8j6s",
"8j6t"
] | 11 | [
"PUB00053560",
"PUB00053561",
"PUB00094490"
] | [
"17065558",
"19172751",
"31586391"
] | [
"Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells.",
"The HP1-p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells.",
"Chromatin Assembly Factor 1 (CAF-1) fa... | [
2007,
2008,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4536
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
3,
3,
1,
1,
1,
6,
3,
1,
1,
18
] | 12 | true | Domain | Chromatin assembly factor 1 subunit A, dimerization domain | Chromatin assembly factor 1 subunit A, dimerization domain | CAF1A_DD | 1 |
IPR022044 | 22,044 | Insecticide toxin TcdB middle/C-terminal | TcdB_toxin_mid/C | Domain | 1,503 | false | false | This domain family is found in bacteria, and is approximately 150 amino acids in length. It occurs in the C-terminal-sided middle region of the bacterial insecticide toxin TcdB. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12255"
] | [
"TcdB_toxin_midC"
] | [
1503
] | 1 | [] | [] | [] | 0 | [
"4igl",
"4o9x",
"5kis",
"6h6e",
"6h6f",
"6h6g",
"6l7i",
"6sue",
"6suf",
"6sup",
"6suq"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomicrobia",
"Opisthokonta",
"ecological metagenomes"
] | [
1249,
3,
247,
4
] | 4 | [] | [] | 0 | true | Domain | Insecticide toxin TcdB middle/C-terminal | Insecticide toxin TcdB middle/C-terminal | TcdB_toxin_mid/C | 2 |
IPR022045 | 22,045 | Insecticide toxin TcdB middle/N-terminal | TcdB_toxin_mid/N | Domain | 2,492 | false | false | This domain family is found in bacteria and archaea, and is typically between 164 and 180 amino acids in length. The family is found in association with . This domain is the N-terminal-sided middle region of the bacterial insecticide toxin TcdB. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12256"
] | [
"TcdB_toxin_midN"
] | [
2492
] | 1 | [] | [] | [] | 0 | [
"4igl",
"4o9x",
"5kis",
"6h6e",
"6h6f",
"6h6g",
"6l7i",
"6sue",
"6suf",
"6sup",
"6suq"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"ecological metagenomes"
] | [
2199,
263,
15,
15
] | 4 | [] | [] | 0 | true | Domain | Insecticide toxin TcdB middle/N-terminal | Insecticide toxin TcdB middle/N-terminal | TcdB_toxin_mid/N | 9 |
IPR022047 | 22,047 | Microcephalin-like | Microcephalin-like | Family | 3,124 | false | false | Microcephalin is implicated in chromosome condensation and DNA damage induced cellular responses [ , ]. It may play a role in neurogenesis and regulation of the size of the cerebral cortex in animals. It is a protein, which if expressed homozygously, causes the organism to have the condition microcephaly - a drasticall... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14625"
] | [
""
] | [
3124
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-2299718",
"R-MMU-2299718"
] | [
"REACTOME:R-HSA-2299718",
"REACTOME:R-MMU-2299718"
] | 2 | [
"2wt8",
"3ktf",
"3pa6",
"3sht",
"3shv",
"3szm",
"3t1n",
"3u3z"
] | 8 | [
"PUB00061832",
"PUB00061833",
"PUB00061834"
] | [
"12046007",
"15199523",
"15220350"
] | [
"Identification of microcephalin, a protein implicated in determining the size of the human brain.",
"Mutations in microcephalin cause aberrant regulation of chromosome condensation.",
"Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1."
] | [
2002,
2004,
2004
] | 3 | [] | [
"IPR029504"
] | 0 | 1 | 0 | [
"Eukaryota",
"viral metagenome"
] | [
3123,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
8,
5,
43,
6,
2,
4
] | 6 | true | Family | Microcephalin-like | Microcephalin-like | Microcephalin-like | 1 |
IPR022049 | 22,049 | FAM69, protein-kinase domain | FAM69_kinase_dom | Domain | 7,435 | false | false | This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12260"
] | [
"PIP49_C"
] | [
7435
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Clostridium pasteurianum BC1",
"Eukaryota"
] | [
1,
7434
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
33,
3,
16,
9,
16
] | 6 | true | Domain | FAM69, protein-kinase domain | FAM69, protein-kinase domain | FAM69_kinase_dom | 9 |
IPR022050 | 22,050 | Thermostable hemolysin | T_hemolysin | Family | 1,621 | false | false | This family of proteins is found in bacteria. Thermostable haemolysin is a pore-forming toxin of bacteria, able to lyse erythrocytes from a number of mammalian species [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12261"
] | [
"T_hemolysin"
] | [
1621
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00079216",
"PUB00079217"
] | [
"2323552",
"12101305"
] | [
"Cloning and characterization of a gene encoding a new thermostable hemolysin from Vibrio parahaemolyticus.",
"Cloning and characterization of a novel haemolysin in Vibrio cholerae O1 that does not directly contribute to the virulence of the organism."
] | [
1990,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1605,
4,
12
] | 3 | [] | [] | 0 | true | Family | Thermostable hemolysin | Thermostable hemolysin | T_hemolysin | 8 |
IPR022052 | 22,052 | Histone-binding protein RBBP4-like, N-terminal | Histone-bd_RBBP4-like_N | Domain | 13,318 | false | false | This entry rerpesnts the N-terminal domain of the histone-binding protein RBBP4. Proteins containing this domain include members from the WD repeat RBAP46 (RBBP7)/RBAP48(RBBP4)/MSI1 family. RBBP4 is a subunit of the chromatin assembly factor 1 (CAF-1) complex. The CAF-1 complex is a conserved heterotrimeric protein com... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12265"
] | [
"CAF1C_H4-bd"
] | [
13318
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1538133",
"R-BTA-212300",
"R-BTA-2559580",
"R-BTA-3214815",
"R-BTA-3214841",
"R-BTA-3214847",
"R-BTA-3214858",
"R-BTA-606279",
"R-BTA-6804758",
"R-BTA-73762",
"R-BTA-8943724",
"R-BTA-8951664",
"R-BTA-8953750",
"R-BTA-9764725",
"R-CEL-1538133",
"R-CEL-2559580",
"R-CEL-3214847",... | [
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA-3214841",
"REACTOME:R-BTA-3214847",
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-606279",
"REACTOME:R-BTA-6804758",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-8943724",
"REACTOME:R-... | 111 | [
"2xu7",
"2xyi",
"2yb8",
"2yba",
"3c99",
"3c9c",
"3cfs",
"3cfv",
"3gfc",
"4pby",
"4pbz",
"4pc0",
"4psw",
"4psx",
"4r7a",
"4xyh",
"4xyi",
"5fxy",
"5vtb",
"5wai",
"5wak",
"5wjc",
"5xwr",
"5xxq",
"5y1u",
"6bw3",
"6bw4",
"6c23",
"6c24",
"6g16",
"6nq3",
"6s1l"... | 68 | [
"PUB00050984"
] | [
"18571423"
] | [
"Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gordonia terrae"
] | [
13317,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
3,
4,
4,
16,
13,
2,
15,
13,
3,
4,
54
] | 12 | true | Domain | Histone-binding protein RBBP4-like, N-terminal | Histone-binding protein RBBP4-like, N-terminal | Histone-bd_RBBP4-like_N | 8 |
IPR022053 | 22,053 | Protein of unknown function DUF3613 | DUF3613 | Family | 1,233 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 126 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12266"
] | [
"DUF3613"
] | [
1233
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"plant metagenome"
] | [
1227,
2,
4
] | 3 | [
"Oryza sativa subsp. japonica"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF3613 | Protein of unknown function DUF3613 | DUF3613 | 8 |
IPR022054 | 22,054 | Protein of unknown function DUF3614 | DUF3614 | Family | 1,191 | false | false | This family of proteins is found in viruses. Proteins in this family are typically between 162 and 495 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12267"
] | [
"DUF3614"
] | [
1191
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Closterovirus"
] | [
1191
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3614 | Protein of unknown function DUF3614 | DUF3614 | 7 |
IPR022055 | 22,055 | Protein of unknown function DUF3612 | DUF3612 | Family | 492 | false | false | This domain family is found in bacteria, and is approximately 180 amino acids in length. The family is found in association with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12268"
] | [
"DUF3612"
] | [
492
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
484,
8
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3612 | Protein of unknown function DUF3612 | DUF3612 | 1 |
IPR022056 | 22,056 | CpG binding protein, C-terminal | CpG-bd_C | Domain | 2,247 | false | false | CpG-binding protein is a transcriptional activator that exhibits a DNA binding specificity for unmethylated CpG motifs [ ]. CpG is made of a PHD1, an acidic, a basic, a coiled-coil, and a PHD2 domains [ , ]. This protein contains three cysteine-rich domains identified at the N-terminal, central region, and C-terminal o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12269"
] | [
"CpG_bind_C"
] | [
2247
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9772755",
"R-CEL-9772755",
"R-DME-9772755",
"R-HSA-381038",
"R-HSA-9772755",
"R-MMU-9772755"
] | [
"REACTOME:R-BTA-9772755",
"REACTOME:R-CEL-9772755",
"REACTOME:R-DME-9772755",
"REACTOME:R-HSA-381038",
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-9772755"
] | 6 | [] | 0 | [
"PUB00018514",
"PUB00094503"
] | [
"10688657",
"11572867"
] | [
"Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.",
"Identification and characterization of the DNA binding domain of CpG-binding protein."
] | [
2000,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2247
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
5,
3,
5
] | 6 | true | Domain | CpG binding protein, C-terminal | CpG binding protein, C-terminal | CpG-bd_C | 6 |
IPR022057 | 22,057 | Chitin synthase export chaperone | Chs7 | Family | 3,428 | false | false | Chs7 is an integral membrane protein that acts as a chaperone for the export of the chitin synthase Chs3 from the endoplasmic reticulum [ , , ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12271",
"PTHR35329"
] | [
"Chs7",
""
] | [
3428,
3368
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017155",
"PUB00091023",
"PUB00091024"
] | [
"15623581",
"15470098",
"10366589"
] | [
"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.",
"Role of chitin synthase genes in Fusarium oxysporum.",
"Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthe... | [
2005,
2004,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3428
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1
] | 2 | true | Family | Chitin synthase export chaperone | Chitin synthase export chaperone | Chs7 | 2 |
IPR022059 | 22,059 | Domain of unknown function DUF3615 | DUF3615 | Domain | 3,978 | false | false | This domain is found in a group of uncharacterised plant proteins, and is typically between 86 and 97 amino acids in length. There is a conserved FAE sequence motif. There is a single completely conserved residue F that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12274"
] | [
"DUF3615"
] | [
3978
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
3978
] | 1 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
196,
12
] | 2 | true | Domain | Domain of unknown function DUF3615 | Domain of unknown function DUF3615 | DUF3615 | 2 |
IPR022060 | 22,060 | Domain of unknown function DUF3616 | DUF3616 | Domain | 1,633 | false | false | This entry represents a domain found in a group of bacterial proteins. There is a conserved GLRGPV sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12275"
] | [
"DUF3616"
] | [
1633
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1624,
2,
7
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3616 | Domain of unknown function DUF3616 | DUF3616 | 3 |
IPR022061 | 22,061 | Protein of unknown function DUF3617 | DUF3617 | Family | 3,346 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 179 amino acids in length. There is a single completely conserved residue C that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12276"
] | [
"DUF3617"
] | [
3346
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3325,
3,
18
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3617 | Protein of unknown function DUF3617 | DUF3617 | 7 |
IPR022062 | 22,062 | Protein of unknown function DUF3618 | DUF3618 | Family | 7,800 | false | false | This domain family is found in bacteria, and is approximately 50 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12277"
] | [
"DUF3618"
] | [
7800
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Biomphalaria pfeifferi",
"metagenomes"
] | [
7762,
1,
37
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3618 | Protein of unknown function DUF3618 | DUF3618 | 3 |
IPR022063 | 22,063 | Complementary sex determination, N-terminal | Sex_determin_N | Domain | 325 | false | false | This entry represents the N-terminal end of the sex determination protein. Sex determination proteins are found in eukaryotes. Proteins in this family are typically between 168 and 410 amino acids in length. It plays a role in the gender determination of around 20% of all animals. In the honeybee, the mechanism of sex ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12278"
] | [
"SDP_N"
] | [
325
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053286",
"PUB00160302"
] | [
"15382141",
"21110346"
] | [
"The dice of fate: the csd gene and how its allelic composition regulates sexual development in the honey bee, Apis mellifera.",
"Function and evolution of sex determination mechanisms, genes and pathways in insects."
] | [
2004,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Pancrustacea"
] | [
325
] | 1 | [] | [] | 0 | true | Domain | Complementary sex determination, N-terminal | Complementary sex determination, N-terminal | Sex_determin_N | 9 |
IPR022064 | 22,064 | Protein of unknown function DUF3619 | DUF3619 | Family | 1,176 | false | false | This protein is found in bacteria. Proteins in this family are about 140 amino acids in length. This protein has two conserved sequence motifs: AAR and DDLP. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12279"
] | [
"DUF3619"
] | [
1176
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadati",
"ecological metagenomes"
] | [
2,
1152,
22
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3619 | Protein of unknown function DUF3619 | DUF3619 | 1 |
IPR022065 | 22,065 | Uncharacterised protein family, TMEM59 | Uncharacterised_TMEM59 | Family | 2,413 | false | false | This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 331 amino acids in length. BSMAP has a putative transmembrane domain and is predicted to be a type I membrane glycoprotein. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12280",
"PTHR28652"
] | [
"BSMAP",
""
] | [
2396,
2339
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9013407",
"R-BTA-9696273",
"R-HSA-9013407",
"R-HSA-9696273",
"R-MMU-9013407",
"R-MMU-9696273",
"R-SSC-9013407",
"R-SSC-9696273"
] | [
"REACTOME:R-BTA-9013407",
"REACTOME:R-BTA-9696273",
"REACTOME:R-HSA-9013407",
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-9013407",
"REACTOME:R-MMU-9696273",
"REACTOME:R-SSC-9013407",
"REACTOME:R-SSC-9696273"
] | 8 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2413
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
8,
5,
10
] | 4 | true | Family | Uncharacterised protein family, TMEM59 | Uncharacterised protein family, TMEM59 | Uncharacterised_TMEM59 | 2 |
IPR022066 | 22,066 | Histidine kinase PdtaS, GAF domain | PdtaS_GAF | Domain | 5,263 | false | false | This entry represents the GAF domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains, both are ubiquitous and form dimeric interfaces. GAF domains are known to bind heme (as can ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12282"
] | [
"GAF_PdtaS"
] | [
5263
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"2ykf",
"2ykh"
] | 2 | [
"PUB00061247",
"PUB00103709",
"PUB00103710",
"PUB00103711"
] | [
"22115998",
"34003742",
"16026786",
"33772870"
] | [
"The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules.",
"Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection.",
"A novel two-component system found in Mycobacterium tuber... | [
2012,
2021,
2005,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"metagenomes"
] | [
5071,
2,
190
] | 3 | [] | [] | 0 | true | Domain | Histidine kinase PdtaS, GAF domain | Histidine kinase PdtaS, GAF domain | PdtaS_GAF | 9 |
IPR022067 | 22,067 | Homeobox protein Hox1A3 N-terminal | HoxA13_N | Domain | 2,594 | false | false | This domain represents the N-terminal region of HoxA13 and other Hox proteins (HoxB13, HoxC13 and HoxD13). HoxA13 is involved in formation of the digital arch of the hands and feet, as well as in correct genital formation [ ]. This domain is found in association with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12284"
] | [
"HoxA13_N"
] | [
2594
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057221"
] | [
"10656931"
] | [
"Evolution of N-terminal sequences of the vertebrate HOXA13 protein."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2594
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
8,
8,
6
] | 4 | true | Domain | Homeobox protein Hox1A3 N-terminal | Homeobox protein Hox1A3 N-terminal | HoxA13_N | 5 |
IPR022068 | 22,068 | Mamastrovirus p20 protein | Mamastrovirus_p20 | Family | 225 | false | false | This family of proteins is found in mamastroviruses such as human astrovirus. This entry represents the p20 protein [ ]. | [
"GO:0004252",
"GO:0070008"
] | [
"serine-type endopeptidase activity",
"serine-type exopeptidase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF12285"
] | [
"Astrovir_pp_1"
] | [
225
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [
"PUB00098608"
] | [
"11799197"
] | [
"Processing of nonstructural protein 1a of human astrovirus."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Astroviridae"
] | [
225
] | 1 | [] | [] | 0 | true | Family | Mamastrovirus p20 protein | Mamastrovirus p20 protein | Mamastrovirus_p20 | 7 |
IPR022069 | 22,069 | Protein of unknown function DUF3622 | DUF3622 | Family | 290 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 72 and 107 amino acids in length. There is a conserved VSK sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12286"
] | [
"DUF3622"
] | [
290
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Protopolystoma xenopodis",
"ecological metagenomes"
] | [
285,
1,
4
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3622 | Protein of unknown function DUF3622 | DUF3622 | 6 |
IPR022071 | 22,071 | Rotavirus VP1 RNA-directed RNA polymerase, C-terminal | Rotavirus_VP1_C | Domain | 3,436 | false | false | This domain is the C-terminal bracelet domain of the rotavirus protein VP1, an RNA-directed RNA polymerase. It surrounds the exit tunnel for dsRNA produced by replication and for the RNA template for transcription [ ]. | [
"GO:0003968"
] | [
"RNA-directed RNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12289"
] | [
"Rotavirus_VP1"
] | [
3436
] | 1 | [
"EC"
] | [
"2.7.7.48"
] | [
"EC:2.7.7.48"
] | 1 | [
"2r7o",
"2r7q",
"2r7r",
"2r7s",
"2r7t",
"2r7u",
"2r7v",
"2r7w",
"2r7x",
"4au6",
"4f5x",
"6ogy",
"6ogz",
"6oj3",
"6oj4",
"6oj5",
"6oj6",
"9c1l"
] | 18 | [
"PUB00054353"
] | [
"19000820"
] | [
"Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
3436
] | 1 | [] | [] | 0 | true | Domain | Rotavirus VP1 RNA-directed RNA polymerase, C-terminal | Rotavirus VP1 RNA-directed RNA polymerase, C-terminal | Rotavirus_VP1_C | 9 |
IPR022072 | 22,072 | Protein of unknown function DUF3624 | DUF3624 | Family | 369 | false | false | This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12292"
] | [
"DUF3624"
] | [
369
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
369
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3624 | Protein of unknown function DUF3624 | DUF3624 | 4 |
IPR022073 | 22,073 | Putative outer membrane core complex of type IVb secretion | T4BSS_DotH_IcmK | Family | 1,220 | false | false | This is a family of bacterial transporter proteins from Proteobacteria. DotH is an integral outer membrane component and it may form an outer membrane complex along with DotD and DotC functionally equivalent to secretins. DotH is the strongest candidate for the VirB9 counterpart of other T4BSS systems [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12293"
] | [
"T4BSS_DotH_IcmK"
] | [
1220
] | 1 | [] | [] | [] | 0 | [
"6x62",
"6x65",
"6x66",
"7muc",
"7mud",
"7mue",
"7muq",
"7mus",
"7muv",
"7muw",
"7muy",
"9ngu",
"9ngv",
"9nh0"
] | 14 | [
"PUB00075640"
] | [
"21743810"
] | [
"Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Plasmid R64",
"metagenomes"
] | [
1210,
2,
1,
7
] | 4 | [] | [] | 0 | true | Family | Putative outer membrane core complex of type IVb secretion | Putative outer membrane core complex of type IVb secretion | T4BSS_DotH_IcmK | 7 |
IPR022074 | 22,074 | Protein of unknown function DUF3626 | DUF3626 | Family | 2,197 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12294"
] | [
"DUF3626"
] | [
2197
] | 1 | [] | [] | [] | 0 | [
"7dn8",
"7dn9"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1902,
275,
14,
6
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3626 | Protein of unknown function DUF3626 | DUF3626 | 7 |
IPR022075 | 22,075 | Symplekin C-terminal | Symplekin_C | Domain | 4,293 | false | false | This domain is found in symplekin. It is approximately 180 amino acids in length and contains a single completely conserved residue P that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12295"
] | [
"Symplekin_C"
] | [
4293
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-159231",
"R-DME-72187",
"R-DME-72203",
"R-DME-73856",
"R-DME-77595",
"R-HSA-159231",
"R-HSA-72187",
"R-HSA-72203",
"R-HSA-73856",
"R-HSA-77595",
"R-MMU-159231",
"R-MMU-72187",
"R-MMU-72203",
"R-MMU-73856",
"R-MMU-77595"
] | [
"REACTOME:R-DME-159231",
"REACTOME:R-DME-72187",
"REACTOME:R-DME-72203",
"REACTOME:R-DME-73856",
"REACTOME:R-DME-77595",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-73856",
"REACTOME:R-HSA-77595",
"REACTOME:R-MMU-159231",
"REACTOME:R-MMU-72187",
"... | 15 | [
"6v4x"
] | 1 | [
"PUB00057220"
] | [
"8769423"
] | [
"Symplekin, a novel type of tight junction plaque protein."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4293
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
17,
1,
2,
1,
5,
6,
5,
5,
32
] | 9 | true | Domain | Symplekin C-terminal | Symplekin C-terminal | Symplekin_C | 5 |
IPR022076 | 22,076 | Limbin | Limbin | Family | 1,106 | false | false | Limbin (EVC2) interacts with AVC and is a positive regulator of the hedgehog signalling pathway. It plays a critical role in bone formation and skeletal development and may be involved in early embryonic morphogenesis [ ]. | [
"GO:0007224"
] | [
"smoothened signaling pathway"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF12297"
] | [
"EVC2_like"
] | [
1106
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5632684",
"R-HSA-5635838",
"R-MMU-5632684"
] | [
"REACTOME:R-HSA-5632684",
"REACTOME:R-HSA-5635838",
"REACTOME:R-MMU-5632684"
] | 3 | [] | 0 | [
"PUB00060695"
] | [
"21356043"
] | [
"Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus."
] | [
2011
] | 1 | [
"IPR026501"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1106
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
3
] | 3 | true | Family | Limbin | Limbin | Limbin | 7 |
IPR022077 | 22,077 | ATP-dependent RNA helicase RhlB | RhlB | Family | 321 | false | false | Proteins in this entry are DEAD Box RhlB RNA Helicases found in Xanthomonadaceae bacteria. | [
"GO:0016817"
] | [
"hydrolase activity, acting on acid anhydrides"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12300"
] | [
"RhlB"
] | [
321
] | 1 | [
"EC"
] | [
"3.6.4.13"
] | [
"EC:3.6.4.13"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae"
] | [
320,
1
] | 2 | [] | [] | 0 | true | Family | ATP-dependent RNA helicase RhlB | ATP-dependent RNA helicase RhlB | RhlB | 9 |
IPR022078 | 22,078 | CD99 antigen-like protein 2 | CD99L2 | Family | 2,654 | false | false | This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12301",
"PTHR15076"
] | [
"CD99L2",
""
] | [
2397,
2575
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-202733"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202733"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2654
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
15,
8,
11
] | 4 | true | Family | CD99 antigen-like protein 2 | CD99 antigen-like protein 2 | CD99L2 | 4 |
IPR022080 | 22,080 | Protein of unknown function DUF3630 | DUF3630 | Family | 794 | false | false | This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12305"
] | [
"DUF3630"
] | [
794
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
792,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3630 | Protein of unknown function DUF3630 | DUF3630 | 6 |
IPR022081 | 22,081 | Domain of unknown function DUF3631 | DUF3631 | Domain | 1,499 | false | false | This domain is found in uncharacterised proteins and in tripartite motif containing (TRIM) protein 41. This protein functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12307"
] | [
"DUF3631"
] | [
1499
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054240"
] | [
"17893151"
] | [
"Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"ecological metagenomes"
] | [
1485,
1,
13
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3631 | Domain of unknown function DUF3631 | DUF3631 | 7 |
IPR022082 | 22,082 | Noelin domain | Noelin_dom | Domain | 4,081 | false | false | This domain is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with . There are two conserved sequence motifs: SAQ and VQN. It is found in Noelin, a glycoprotein which is secreted mainly by postmitotic neurogenic tissues in the developing central and peripheral ne... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12308"
] | [
"Noelin-1"
] | [
4081
] | 1 | [] | [] | [] | 0 | [
"5amo"
] | 1 | [
"PUB00075095"
] | [
"11784068"
] | [
"The secreted glycoprotein Noelin-1 promotes neurogenesis in Xenopus."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4081
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
14,
10,
14
] | 4 | true | Domain | Noelin domain | Noelin domain | Noelin_dom | 6 |
IPR022083 | 22,083 | KIF-1 binding protein | KBP | Family | 2,180 | false | false | KIF1 binding protein (KBP) is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12309"
] | [
"KBP_C"
] | [
2180
] | 1 | [] | [] | [] | 0 | [
"6zpg",
"6zph",
"7rsi",
"7rsq",
"7ryp",
"7ryq"
] | 6 | [
"PUB00057219"
] | [
"16225668"
] | [
"The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2180
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
8,
4,
5
] | 5 | true | Family | KIF-1 binding protein | KIF-1 binding protein | KBP | 8 |
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