interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR024354 | 24,354 | Hepatitis A virus, protein VP1-2A | Hepatitis_A_VP1-2A | Family | 1,837 | false | false | This is a family of the viral protein found in hepatitis A viruses. HAV is unique among picornaviruses in targeting the liver [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12944"
] | [
"HAV_VP"
] | [
1837
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22.28",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22.28",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 8 | [
"4qpg",
"4qpi",
"5wte",
"5wtf",
"5wth",
"6jhq",
"6jhr",
"6jhs",
"6jht"
] | 9 | [
"PUB00075612"
] | [
"25327248"
] | [
"Hepatitis A virus and the origins of picornaviruses."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
1837
] | 1 | [] | [] | 0 | true | Family | Hepatitis A virus, protein VP1-2A | Hepatitis A virus, protein VP1-2A | Hepatitis_A_VP1-2A | 6 |
IPR024355 | 24,355 | Conjugative transposon protein TraQ, bacteroidetes | TraQ_bacteroidetes | Family | 1,916 | false | false | This entry represents the conjugative transposon protein TraQ from Bacteroides thetaiotaomicron and similar sequences from Bacteroides species. TraQ shares structural similarity to other proteins involved in pili production for bacterial cell attachment [ ]. The gene coding for this protein, located in a conjugate tran... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12988"
] | [
"TraQ_transposon"
] | [
1916
] | 1 | [] | [] | [] | 0 | [
"2l3b",
"2l7q",
"4lba"
] | 3 | [
"PUB00056011",
"PUB00056012",
"PUB00057520"
] | [
"15790854",
"16735464",
"22116783"
] | [
"Glycan foraging in vivo by an intestine-adapted bacterial symbiont.",
"A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism.",
"Solution NMR structure of BT_0084, a conjugative transposon lipoprotein from Bacteroides thetaiotamicron."... | [
2005,
2006,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes",
"virus sp. ctLpa4"
] | [
1871,
44,
1
] | 3 | [] | [] | 0 | true | Family | Conjugative transposon protein TraQ, bacteroidetes | Conjugative transposon protein TraQ, bacteroidetes | TraQ_bacteroidetes | 7 |
IPR024356 | 24,356 | Protein of unknown function DUF3873 | DUF3873 | Family | 719 | false | false | This entry represents a family of uncharacterised proteins found primarily in Bacteroides species. The Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12989"
] | [
"DUF3873"
] | [
719
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056011",
"PUB00056012"
] | [
"15790854",
"16735464"
] | [
"Glycan foraging in vivo by an intestine-adapted bacterial symbiont.",
"A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism."
] | [
2005,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes",
"unclassified Caudoviricetes"
] | [
704,
9,
6
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3873 | Protein of unknown function DUF3873 | DUF3873 | 1 |
IPR024357 | 24,357 | Argonaut, glycine-rich domain | Argonaut_Gly-rich | Domain | 1,284 | false | false | This domain is found in the N terminus of some argonaut proteins. Argonaut (AGO) proteins are involved in RNA-mediated post-transcriptional gene silencing [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12764"
] | [
"Gly-rich_Ago1"
] | [
1284
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056191"
] | [
"16081530"
] | [
"Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1284
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
6,
88
] | 3 | true | Domain | Argonaut, glycine-rich domain | Argonaut, glycine-rich domain | Argonaut_Gly-rich | 7 |
IPR024358 | 24,358 | Non-structural protein NSP3, N-terminal, betacoronavirus | NSP3_N_bCoV | Domain | 3,892 | false | false | The multi-domain non-structural protein NSP3 is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. While some of the domains differ between CoV genera, eight domains of NSP3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12379"
] | [
"bCoV_NSP3_N"
] | [
3892
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.50",
"3.4.19.12",
"3.4.22.-",
"3.4.22.69",
"PWY-7375",
"R-HSA-191859",
"R-HSA-918233",
"R-HSA-9679504",
"R-HSA-9682706",
"R-HSA-9682708",
"R-HSA-9683439",
"R-HSA-9684325",
"R-HSA-9692916",
"R-HSA-9694271",
"R-HSA-9694301",
"R-HSA-9694676",
"R-HSA-9694686",
"R-HSA-9694786",
... | [
"EC:2.7.7.50",
"EC:3.4.19.12",
"EC:3.4.22.-",
"EC:3.4.22.69",
"METACYC:PWY-7375",
"REACTOME:R-HSA-191859",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-9679504",
"REACTOME:R-HSA-9682706",
"REACTOME:R-HSA-9682708",
"REACTOME:R-HSA-9683439",
"REACTOME:R-HSA-9684325",
"REACTOME:R-HSA-9692916",
"R... | 21 | [
"2acf",
"2fav",
"2gri",
"2idy",
"7kag",
"7kg3",
"7kxb",
"7lg7",
"7pku",
"7ti9",
"7wzo",
"8cb3",
"8hda",
"8xab",
"8yax",
"8yb5",
"8yb7"
] | 17 | [
"PUB00047544",
"PUB00094055",
"PUB00094069",
"PUB00094113"
] | [
"17728234",
"31776274",
"29128390",
"18367524"
] | [
"Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.",
"Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle.",
"Nsp3 of coronaviruses: Structures and fu... | [
2007,
2020,
2018,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Coronaviridae"
] | [
3892
] | 1 | [] | [] | 0 | true | Domain | Non-structural protein NSP3, N-terminal, betacoronavirus | Non-structural protein NSP3, N-terminal, betacoronavirus | NSP3_N_bCoV | 6 |
IPR024359 | 24,359 | Peroxisome assembly protein 22 | Peroxin-22 | Family | 144 | false | false | Peroxin-22 is an integral peroxisomal membrane protein. The N terminus of peroxin-22 is located in the matrix, while the C terminus is located in the cytosol. Peroxin-22 interacts with the ubiquitin-conjugating enzyme Pex4p, anchoring it at the peroxisomal membrane [ ]. This association is required for ubiquitination o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12827"
] | [
"Peroxin-22"
] | [
144
] | 1 | [] | [] | [] | 0 | [
"2y9m",
"2y9p",
"4bwf",
"5nkz"
] | 4 | [
"PUB00056014",
"PUB00087046",
"PUB00101054",
"PUB00101055"
] | [
"10402463",
"22085930",
"29288668",
"23896733"
] | [
"Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane.",
"Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.",
"Structural insights into K48-link... | [
1999,
2012,
2018,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
144
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Peroxisome assembly protein 22 | Peroxisome assembly protein 22 | Peroxin-22 | 1 |
IPR024360 | 24,360 | Cytoplasmic envelopment protein 3, herpesvirus | Herpesvirus_CEP3 | Family | 57 | false | false | This entry contains viral proteins that are involved in virion envelopment and egress. It includes Epstein-Barr virus (EBV) BBLF1 protein (also known as cytoplasmic envelopment protein 3 and Herpesvirus UL11 homologue), which is present in the tegument layer of EBV and is involved in virion maturation. BBLF1 also parti... | [] | [] | [] | 0 | [
"HAMAP",
"PFAM"
] | [
"MF_04042",
"PF10813"
] | [
"HSV_CEP3_gammahv",
"Herpesvir_UL11"
] | [
55,
54
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00082568"
] | [
"22740416"
] | [
"Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Orthoherpesviridae"
] | [
57
] | 1 | [] | [] | 0 | true | Family | Cytoplasmic envelopment protein 3, herpesvirus | Cytoplasmic envelopment protein 3, herpesvirus | Herpesvirus_CEP3 | 7 |
IPR024362 | 24,362 | Y11A | Y11A | Family | 315 | false | false | This entry represents Uncharacterized 6.1 kDa protein in uvsW-uvsY intergenic region (Y11A) and other uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10886"
] | [
"DUF2685"
] | [
315
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Flagellimonas marina",
"Viruses"
] | [
1,
314
] | 2 | [] | [] | 0 | true | Family | Y11A | Y11A | Y11A | 2 |
IPR024363 | 24,363 | Protein of unknown function DUF3853 | DUF3853 | Family | 779 | false | false | This entry represents a family of uncharacterised proteins that were found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12964"
] | [
"DUF3853"
] | [
779
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Viruses",
"metagenomes"
] | [
749,
5,
25
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3853 | Protein of unknown function DUF3853 | DUF3853 | 2 |
IPR024364 | 24,364 | Baseplate hub assembly protein Gp26/51 domain | Gp26/51_dom | Domain | 1,558 | false | false | This entry represents a domain that covers the whole length of the protein in Gp26 and the N-terminal region of Gp51, both base plate proteins from bacteriophage T4 encoded by late genes [ ]. Proteins in this group have a single completely conserved residue S that may be functionally important. Gp26 is a structural com... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12322"
] | [
"T4_baseplate"
] | [
1558
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056192",
"PUB00081408",
"PUB00081409",
"PUB00161742"
] | [
"2763463",
"21129200",
"6387173",
"34826709"
] | [
"Bacteriophage T4 late gene expression: overlapping promoters direct divergent transcription of the base plate gene cluster.",
"Morphogenesis of the T4 tail and tail fibers.",
"Identification of bacteriophage T4D gene products 26 and 51 as baseplate hub structural components.",
"Identification of the tail ass... | [
1989,
2010,
1984,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Protostomia",
"Viruses",
"metagenomes"
] | [
4,
484,
7,
1001,
62
] | 5 | [] | [] | 0 | true | Domain | Baseplate hub assembly protein Gp26/51 domain | Baseplate hub assembly protein Gp26/51 domain | Gp26/51_dom | 8 |
IPR024365 | 24,365 | Protein of unknown function DUF3839 | DUF3839 | Family | 2,551 | false | false | This is a family of uncharacterised proteins that are found in Trichomonas. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12943"
] | [
"DUF3839"
] | [
2551
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
2549,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3839 | Protein of unknown function DUF3839 | DUF3839 | 6 |
IPR024366 | 24,366 | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | FTO_C | Domain | 1,616 | false | false | Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [ ]. FTO activity is highest towards single-stranded RNA containing 3-met... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12934"
] | [
"FTO_CTD"
] | [
1616
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.14.11.-",
"1.14.11.53",
"PWY-102",
"PWY-1187",
"PWY-5035",
"PWY-5036",
"PWY-5047",
"PWY-5070",
"PWY-5349",
"PWY-6085",
"PWY-6086",
"PWY-6495",
"PWY-6682",
"PWY-6915",
"PWY-6919",
"PWY-7150",
"PWY-7151",
"PWY-7232",
"PWY-7274",
"PWY-7298",
"PWY-7398",
"PWY-7419",
"PWY-7... | [
"EC:1.14.11.-",
"EC:1.14.11.53",
"METACYC:PWY-102",
"METACYC:PWY-1187",
"METACYC:PWY-5035",
"METACYC:PWY-5036",
"METACYC:PWY-5047",
"METACYC:PWY-5070",
"METACYC:PWY-5349",
"METACYC:PWY-6085",
"METACYC:PWY-6086",
"METACYC:PWY-6495",
"METACYC:PWY-6682",
"METACYC:PWY-6915",
"METACYC:PWY-691... | 39 | [
"3lfm",
"4cxw",
"4cxx",
"4cxy",
"4idz",
"4ie0",
"4ie4",
"4ie5",
"4ie6",
"4ie7",
"4qho",
"4qkn",
"4zs2",
"4zs3",
"5dab",
"5f8p",
"5zmd",
"6aej",
"6ak4",
"6akw",
"7ckk",
"7e8z",
"7wcv",
"8it9",
"9knh",
"9kni",
"9ohs",
"9vg4"
] | 28 | [
"PUB00056016",
"PUB00056017",
"PUB00056018",
"PUB00056019",
"PUB00099124"
] | [
"20376003",
"17991826",
"18775698",
"19234441",
"28553460"
] | [
"Crystal structure of the FTO protein reveals basis for its substrate specificity.",
"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.",
"Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.",
"Inactiva... | [
2010,
2007,
2008,
2009,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1616
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
13,
1,
4
] | 4 | true | Domain | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | FTO_C | 7 |
IPR024367 | 24,367 | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | FTO_cat_dom | Domain | 1,634 | false | false | Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [ ]. FTO activity is highest towards single-stranded RNA containing 3-met... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF12933",
"SM01223"
] | [
"FTO_NTD",
"FTO_NTD"
] | [
1634,
1585
] | 2 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.14.11.-",
"1.14.11.53",
"PWY-102",
"PWY-1187",
"PWY-5035",
"PWY-5036",
"PWY-5047",
"PWY-5070",
"PWY-5349",
"PWY-6085",
"PWY-6086",
"PWY-6495",
"PWY-6682",
"PWY-6915",
"PWY-6919",
"PWY-7150",
"PWY-7151",
"PWY-7232",
"PWY-7274",
"PWY-7298",
"PWY-7398",
"PWY-7419",
"PWY-7... | [
"EC:1.14.11.-",
"EC:1.14.11.53",
"METACYC:PWY-102",
"METACYC:PWY-1187",
"METACYC:PWY-5035",
"METACYC:PWY-5036",
"METACYC:PWY-5047",
"METACYC:PWY-5070",
"METACYC:PWY-5349",
"METACYC:PWY-6085",
"METACYC:PWY-6086",
"METACYC:PWY-6495",
"METACYC:PWY-6682",
"METACYC:PWY-6915",
"METACYC:PWY-691... | 39 | [
"3lfm",
"4cxw",
"4cxx",
"4cxy",
"4idz",
"4ie0",
"4ie4",
"4ie5",
"4ie6",
"4ie7",
"4qho",
"4qkn",
"4zs2",
"4zs3",
"5dab",
"5f8p",
"5zmd",
"6aej",
"6ak4",
"6akw",
"7ckk",
"7e8z",
"7wcv",
"8it9",
"9knh",
"9kni",
"9ohs",
"9vg4"
] | 28 | [
"PUB00056016",
"PUB00056017",
"PUB00056018",
"PUB00056019",
"PUB00099124"
] | [
"20376003",
"17991826",
"18775698",
"19234441",
"28553460"
] | [
"Crystal structure of the FTO protein reveals basis for its substrate specificity.",
"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.",
"Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.",
"Inactiva... | [
2010,
2007,
2008,
2009,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1634
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
11,
3,
5
] | 4 | true | Domain | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | FTO_cat_dom | 5 |
IPR024370 | 24,370 | PBP domain | PBP_domain | Domain | 51,773 | false | false | This entry represents members of the periplasmic binding domain superfamily [ ]. It is often associated with a helix-turn-helix domain. | [] | [] | [] | 0 | [
"PFAM",
"PFAM"
] | [
"PF12727",
"PF12849"
] | [
"PBP_like",
"PBP_like_2"
] | [
5593,
46181
] | 2 | [
"REACTOME"
] | [
"R-HSA-9637628"
] | [
"REACTOME:R-HSA-9637628"
] | 1 | [
"1a40",
"1a54",
"1a55",
"1ixg",
"1ixh",
"1ixi",
"1oib",
"1pbp",
"1pc3",
"1qui",
"1quj",
"1quk",
"1qul",
"1twy",
"2abh",
"2q9t",
"2v3q",
"2z22",
"3cvg",
"3kn3",
"3lr1",
"3muq",
"3w9v",
"3w9w",
"4ecf",
"4exl",
"4f18",
"4f19",
"4f1u",
"4f1v",
"4gd5",
"4h1x"... | 51 | [
"PUB00056198"
] | [
"11741199"
] | [
"The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2354,
47232,
1268,
71,
848
] | 5 | [
"Escherichia coli (strain K12)",
"Homo sapiens"
] | [
1,
2
] | 2 | true | Domain | PBP domain | PBP domain | PBP_domain | 9 |
IPR024371 | 24,371 | Acetyl-coenzyme A transporter 1-like | AcetylCoA_trans_1-like | Family | 6,394 | false | false | This entry represents acetyl-coenzyme A transporter 1 and related proteins. Acetyl-coenzyme A transporter 1 is an acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen [ , ]. Within the ER lumen, specific ER-based acetyl-CoA:lysine acetyltransfer... | [
"GO:0008521",
"GO:0035348",
"GO:0016020"
] | [
"acetyl-CoA transmembrane transporter activity",
"acetyl-CoA transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF13000"
] | [
"Acatn"
] | [
6394
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-425397",
"R-HSA-5619061",
"R-MMU-425397",
"R-RNO-425397",
"R-SCE-425397",
"R-SPO-425397"
] | [
"REACTOME:R-HSA-425397",
"REACTOME:R-HSA-5619061",
"REACTOME:R-MMU-425397",
"REACTOME:R-RNO-425397",
"REACTOME:R-SCE-425397",
"REACTOME:R-SPO-425397"
] | 6 | [
"9m0s"
] | 1 | [
"PUB00056020",
"PUB00056194",
"PUB00163276",
"PUB00163277"
] | [
"10570973",
"9096318",
"20826464",
"24828632"
] | [
"Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA.",
"Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter.",
"AT-1 is the ER membrane acetyl-CoA transporter and i... | [
1999,
1997,
2010,
2014
] | 4 | [
"IPR004752"
] | [
"IPR014090"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1345,
5032,
17
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
5,
2,
3,
9,
3,
1,
2,
2,
1
] | 9 | true | Family | Acetyl-coenzyme A transporter 1-like | Acetyl-coenzyme A transporter 1-like | AcetylCoA_trans_1-like | 1 |
IPR024372 | 24,372 | Proteasome component Ecm29, N-terminal | Ecm29_N | Domain | 4,751 | false | false | Ecm29 is an adapter/scaffolding protein that tethers the proteasome core particle to the regulatory particle, stabilising the interaction between these two components [ , , ]. This entry represents a HEAT-repeats containing domain found at the N-terminal of ECM29. The N-terminal half of the protein binds the endocytic ... | [
"GO:0060090",
"GO:0043248"
] | [
"molecular adaptor activity",
"proteasome assembly"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF13001"
] | [
"ECM29_N"
] | [
4751
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000148",
"PUB00000524",
"PUB00001329",
"PUB00004123",
"PUB00005460",
"PUB00030848",
"PUB00056021",
"PUB00056022",
"PUB00056023",
"PUB00061901",
"PUB00080992"
] | [
"2643381",
"7682410",
"7697118",
"1317508",
"8882582",
"9087403",
"12408819",
"15496406",
"18026118",
"20682791",
"2535672"
] | [
"The multicatalytic proteinase of mammalian cells.",
"Proteasomes: multicatalytic proteinase complexes.",
"Proteasomes. Multicatalytic proteinase complexes.",
"Proteolysis, proteasomes and antigen presentation.",
"Proteasomes: destruction as a programme.",
"Structure of 20S proteasome from yeast at 2.4 A ... | [
1989,
1993,
1993,
1992,
1996,
1997,
2002,
2004,
2007,
2010,
1989
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4751
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
1,
6,
8,
1,
9,
9,
1,
1,
18
] | 12 | true | Domain | Proteasome component Ecm29, N-terminal | Proteasome component Ecm29, N-terminal | Ecm29_N | 5 |
IPR024373 | 24,373 | Bacteriophage T4, IpI | Phage_T4_IpI | Family | 83 | false | false | This family of proteins represents IPI from bacteriophage T4. This protein is a nuclease inhibitor which is injected by T4 to protect its DNA from gmrS/gmrD CT of pathogenic Escherichia coli into the infected host [ ]. The structure of this protein consists of two small β-sheets flanked by N and C termini by α-helices.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11634"
] | [
"IPI_T4"
] | [
83
] | 1 | [] | [] | [] | 0 | [
"2jub"
] | 1 | [
"PUB00048091"
] | [
"18037438"
] | [
"Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
83
] | 1 | [] | [] | 0 | true | Family | Bacteriophage T4, IpI | Bacteriophage T4, IpI | Phage_T4_IpI | 8 |
IPR024374 | 24,374 | Bacteriophage phi-29 scaffolding protein Gp7 | Phage_phi-29_Gp7 | Family | 31 | false | false | This protein is also referred to as Gp7. The protein contains a DNA-binding function and may have a role in mediating the structural transition from prohead to mature virus and also scaffold release [ ].Gp7 is arranged within the capsid as a series of concentric shells [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11418"
] | [
"Scaffolding_pro"
] | [
31
] | 1 | [] | [] | [] | 0 | [
"1no4",
"1noh",
"3mtu",
"3oa7",
"4iff",
"4xa1",
"4xa3",
"4xa6",
"5cj1",
"5wjb",
"5wlq",
"5wme",
"6pf2",
"6pfp",
"8f2m"
] | 15 | [
"PUB00029158"
] | [
"12778115"
] | [
"Bacteriophage phi29 scaffolding protein gp7 before and after prohead assembly."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Eukaryota",
"Helicobacter pylori"
] | [
23,
7,
1
] | 3 | [] | [] | 0 | true | Family | Bacteriophage phi-29 scaffolding protein Gp7 | Bacteriophage phi-29 scaffolding protein Gp7 | Phage_phi-29_Gp7 | 7 |
IPR024376 | 24,376 | Phlebovirus, non structural protein | RVFV_non-structural | Family | 107 | false | false | This family contains several Phlebovirus non structural proteins which act as a major determinant of virulence by antagonising interferon beta gene expression [ ] or by downregulating the host basal transcription factor TFIIH subunit p62 [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003956"
] | [
"NS-S_PhleboV"
] | [
107
] | 1 | [] | [] | [] | 0 | [
"7f64",
"7f66",
"7f67",
"7rlo",
"7vlk",
"8wcm"
] | 6 | [
"PUB00056025",
"PUB00078869"
] | [
"18225953",
"21543505"
] | [
"A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.",
"NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62."
] | [
2008,
2011
] | 2 | [
"IPR039434"
] | [] | 1 | 0 | 1 | [
"Phlebovirus"
] | [
107
] | 1 | [] | [] | 0 | true | Family | Phlebovirus, non structural protein | Phlebovirus, non structural protein | RVFV_non-structural | 7 |
IPR024377 | 24,377 | RNA-binding protein, B2 | RNA-bd_B2 | Family | 6 | false | false | Protein B2 binds double-strand RNA (dsRNA) with high affinity and suppresses the host RNA silencing-based antiviral response. B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cle... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11473"
] | [
"B2"
] | [
6
] | 1 | [] | [] | [] | 0 | [
"2az0",
"2az2",
"2b9z"
] | 3 | [
"PUB00039458"
] | [
"16228003"
] | [
"Dual modes of RNA-silencing suppression by Flock House virus protein B2."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Nodaviridae"
] | [
6
] | 1 | [] | [] | 0 | true | Family | RNA-binding protein, B2 | RNA-binding protein, B2 | RNA-bd_B2 | 2 |
IPR024378 | 24,378 | RNA-directed RNA polymerase, hantavirus, N-terminal | RNA-dir_pol_N_hantavirus | Domain | 515 | false | false | This domain is found in the RNA-directed RNA polymerase. It is located towards the N terminus and is approximately 40 amino acids in length. There is a conserved MFNLKF sequence motif. There are two completely conserved residues (E and P) that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12426"
] | [
"DUF3674"
] | [
515
] | 1 | [
"EC"
] | [
"2.7.7.48"
] | [
"EC:2.7.7.48"
] | 1 | [
"8c4s",
"8c4t",
"8c4u",
"8c4v",
"8ci5",
"8p1j",
"8p1k",
"8p1l",
"8p1m",
"8p1n",
"8qe5",
"8qgt",
"8qgu",
"8qh3",
"8qhd"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Hantaviridae"
] | [
515
] | 1 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, hantavirus, N-terminal | RNA-directed RNA polymerase, hantavirus, N-terminal | RNA-dir_pol_N_hantavirus | 2 |
IPR024379 | 24,379 | Waikavirus, capsid protein 1 | Waikavirus_capsid-1 | Family | 151 | false | false | This entry represents capsid protein 1 of Rice tungro spherical virus [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12264"
] | [
"Waikav_capsid_1"
] | [
151
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056205"
] | [
"12466496"
] | [
"Characterization of a protein from Rice tungro spherical virus with serine proteinase-like activity."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses"
] | [
8,
143
] | 2 | [] | [] | 0 | true | Family | Waikavirus, capsid protein 1 | Waikavirus, capsid protein 1 | Waikavirus_capsid-1 | 5 |
IPR024380 | 24,380 | Domain of unknown function DUF3848 | DUF3848 | Domain | 337 | false | false | This domain is found in a family of uncharacterised proteins found by clustering human gut metagenomic sequences[ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12959"
] | [
"DUF3848"
] | [
337
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
329,
8
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3848 | Domain of unknown function DUF3848 | DUF3848 | 3 |
IPR024381 | 24,381 | Protein of unknown function DUF2561 | DUF2561 | Family | 355 | false | false | This family of proteins with unknown function appears to be found predominantly in Mycobacterium spp. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10812"
] | [
"DUF2561"
] | [
355
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"marine sediment metagenome"
] | [
354,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2561 | Protein of unknown function DUF2561 | DUF2561 | 9 |
IPR024382 | 24,382 | Vacuolar sorting protein Vps3844, C-terminal domain | Vps3844_C | Domain | 1,480 | false | false | This entry represents the C-terminal domain (previously known as DUF3844) of the uncharacterised endoplasmic reticulum membrane protein C1709.03 from S. pombe, which was renamed to vacuolar sorting protein Vps3844 [ ]. This domain contains 8 largely conserved cysteine residues and the region comprising amino acids 354 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12955"
] | [
"Vps3844_C"
] | [
1480
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00156045"
] | [
"39477503"
] | [
"A DUF3844 domain-containing protein is required for vacuolar protein sorting in Schizosaccharomyces pombe."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1480
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Vacuolar sorting protein Vps3844, C-terminal domain | Vacuolar sorting protein Vps3844, C-terminal domain | Vps3844_C | 3 |
IPR024383 | 24,383 | Domain of unknown function DUF3849 | DUF3849 | Domain | 581 | false | false | This domain is found in a family of uncharacterised proteins found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12960"
] | [
"DUF3849"
] | [
581
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Euroglyphus maynei",
"metagenomes"
] | [
564,
1,
16
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3849 | Domain of unknown function DUF3849 | DUF3849 | 8 |
IPR024384 | 24,384 | Protein of unknown function DUF2742 | DUF2742 | Family | 266 | false | false | Members of this family of actinobacterial proteins are described as putative PhiRv1/PhiRv2 prophage proteins, however their function is unknown. This two prophages have been detected in the genome sequence of Mycobacterium tuberculosis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10888"
] | [
"DUF2742"
] | [
266
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004280"
] | [
"9634230"
] | [
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
266
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2742 | Protein of unknown function DUF2742 | DUF2742 | 4 |
IPR024385 | 24,385 | Domain of unknown function DUF3854 | DUF3854 | Domain | 1,288 | false | false | This domain of unknown function was found by clustering human gut metagenomic sequences [ ]. It may be related to the Toprim domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12965"
] | [
"DUF3854"
] | [
1288
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Physcomitrium patens",
"Viruses",
"metagenomes"
] | [
1267,
1,
7,
13
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3854 | Domain of unknown function DUF3854 | DUF3854 | 4 |
IPR024386 | 24,386 | Protein of unknown function DUF2532 | DUF2532 | Family | 42 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10811"
] | [
"DUF2532"
] | [
42
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rickettsia"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2532 | Protein of unknown function DUF2532 | DUF2532 | 4 |
IPR024387 | 24,387 | Peptidase C3G, Picornavirus | Pept_C3G_Picornavir | Domain | 265 | false | false | Viruses in the order Picornavirales infect different vertebrate, invertebrate, and plant hosts and are responsible for a variety of human, animal, and plant diseases. These viruses have a single-stranded, positive sense RNA genome that generally translates a large precursor polyprotein which is proteolytically cleaved ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12381"
] | [
"Peptidase_C3G"
] | [
265
] | 1 | [
"EC",
"EC"
] | [
"2.7.7.48",
"3.4.22.-"
] | [
"EC:2.7.7.48",
"EC:3.4.22.-"
] | 2 | [] | 0 | [
"PUB00032759",
"PUB00050441",
"PUB00056181",
"PUB00056182",
"PUB00056357",
"PUB00056400",
"PUB00094816",
"PUB00094817"
] | [
"15654079",
"19144641",
"9683576",
"15503215",
"21835784",
"21795339",
"18293057",
"22534091"
] | [
"Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity.",
"Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.",
"Rice tungro spherical virus polyprotein processing: id... | [
2005,
2009,
1998,
2005,
2011,
2011,
2008,
2012
] | 8 | [
"IPR044067"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
15,
248,
2
] | 3 | [] | [] | 0 | true | Domain | Peptidase C3G, Picornavirus | Peptidase C3G, Picornavirus | Pept_C3G_Picornavir | 9 |
IPR024388 | 24,388 | Large ribosomal subunit protein mL58 | Ribosomal_mL58 | Family | 1,496 | false | false | This entry represents the essential mitochondrial ribosomal mL58 (also known as 54S ribosomal L20) family from fungi [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28266"
] | [
""
] | [
1496
] | 1 | [] | [] | [] | 0 | [
"3j6b",
"5mrc",
"5mre",
"5mrf",
"6ywe",
"6yws",
"6ywv",
"6ywx",
"6ywy"
] | 9 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00056136"
] | [
"11297922",
"11290319",
"11114498",
"2183197"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Cloning and characterization of nuclear genes for two mitochondrial ribosomal proteins in Saccharomyces cerevisiae."
] | [
2001,
2001,
2000,
1990
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1496
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Large ribosomal subunit protein mL58 | Large ribosomal subunit protein mL58 | Ribosomal_mL58 | 7 |
IPR024389 | 24,389 | Baseplate tail-tube protein gp48, T4-like virus | Gp48_T4-like | Family | 410 | false | false | This viral tail tube protein is also referred to as Gp48. It is required for the assembly and length regulation of the tail tube of bacteriophage T4 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11091"
] | [
"T4_tail_cap"
] | [
410
] | 1 | [] | [] | [] | 0 | [
"5iv5",
"9f4a",
"9f4b"
] | 3 | [
"PUB00056026"
] | [
"2139268"
] | [
"Expression and regulation of genes coding for three bacteriophage T4 tail tube-associated proteins."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Viruses"
] | [
7,
403
] | 2 | [] | [] | 0 | true | Family | Baseplate tail-tube protein gp48, T4-like virus | Baseplate tail-tube protein gp48, T4-like virus | Gp48_T4-like | 6 |
IPR024390 | 24,390 | RNA polymerase, 132kDa subunit, poxvirus-type | RNA_pol_132_poxvirus | Family | 177 | false | false | All three classes of poxvirus genes -early, intermediate and late -are transcribed by the viral RNA polymerase compex [ ]. This complex is composed of nine distinct subunits which total more than 500kDa in mass. The two largest subunits (147 and 136kDa) are homologous to the largest subunits of eukaryotic and prokaryot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12415"
] | [
"rpo132"
] | [
177
] | 1 | [
"EC"
] | [
"2.7.7.6"
] | [
"EC:2.7.7.6"
] | 1 | [
"6rfl",
"6ric",
"6rid",
"6rie",
"7amv",
"7aof",
"7aoh",
"7aoz",
"7ap8",
"7ap9",
"8c8h",
"8p0j",
"8p0k",
"8p0n",
"8rqk",
"9ex9",
"9fpy",
"9fq6"
] | 18 | [
"PUB00035728"
] | [
"12917449"
] | [
"Vaccinia virus transcription."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
177
] | 1 | [] | [] | 0 | true | Family | RNA polymerase, 132kDa subunit, poxvirus-type | RNA polymerase, 132kDa subunit, poxvirus-type | RNA_pol_132_poxvirus | 8 |
IPR024391 | 24,391 | LDB19, N-terminal | LDB19_N | Domain | 1,445 | false | false | This entry represents a predicted Ig-like β sandwich domain found towards the N terminus of protein LDB19 [ ]. It is also found in other sequences and is related to the arrestin N-terminal fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13002"
] | [
"LDB19"
] | [
1445
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-844456",
"R-SPO-844456"
] | [
"REACTOME:R-SCE-844456",
"REACTOME:R-SPO-844456"
] | 2 | [] | 0 | [
"PUB00056037"
] | [
"19794886"
] | [
"The arrestin fold: variations on a theme."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1445
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2
] | 3 | true | Domain | LDB19, N-terminal | LDB19, N-terminal | LDB19_N | 5 |
IPR024392 | 24,392 | Protein of unknown function DUF2688 | DUF2688 | Family | 59 | false | false | Members of this protein family are annotated as KleB, and may play a role in the regulation of transcription in plasmids. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10892"
] | [
"DUF2688"
] | [
59
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"plasmids"
] | [
54,
5
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2688 | Protein of unknown function DUF2688 | DUF2688 | 6 |
IPR024393 | 24,393 | Mechanosensitive ion channel MscS, porin domain | MscS_porin | Domain | 5,100 | false | false | The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock [ ]. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are hept... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12795"
] | [
"MscS_porin"
] | [
5100
] | 1 | [] | [] | [] | 0 | [
"7uw5",
"7ux1"
] | 2 | [
"PUB00056120",
"PUB00056121"
] | [
"10202137",
"12080120"
] | [
"Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity.",
"Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics... | [
1999,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
5065,
25,
4,
6
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Mechanosensitive ion channel MscS, porin domain | Mechanosensitive ion channel MscS, porin domain | MscS_porin | 2 |
IPR024394 | 24,394 | RNA polymerase, 30kDa subunit, chordopox-type, N-terminal | RNA_pol_30_chordopoxvir-type_N | Domain | 264 | false | false | All three classes of poxvirus genes -early, intermediate and late -are transcribed by the viral RNA polymerase compex [ ]. This complex is composed of nine distinct subunits which total more than 500kDa in mass. The two largest subunits (147 and 136kDa) are homologous to the largest subunits of eukaryotic and prokaryot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12410"
] | [
"rpo30_N"
] | [
264
] | 1 | [
"EC"
] | [
"2.7.7.6"
] | [
"EC:2.7.7.6"
] | 1 | [
"6rfl",
"6ric",
"6rid",
"6rie",
"7amv",
"7aof",
"7aoh",
"7aoz",
"7ap8",
"7ap9",
"8c8h",
"8p0j",
"8p0k",
"8p0n",
"8rqk",
"9ex9",
"9fpy",
"9fq6"
] | 18 | [
"PUB00003664",
"PUB00035728",
"PUB00035729"
] | [
"2398897",
"12917449",
"2214020"
] | [
"Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.",
"Vaccinia virus transcription.",
"Vaccinia virus gene encoding a 30-kilodalton subunit of the viral DNA-dependent RNA polymerase."
] | [
1990,
2003,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
264
] | 1 | [] | [] | 0 | true | Domain | RNA polymerase, 30kDa subunit, chordopox-type, N-terminal | RNA polymerase, 30kDa subunit, chordopox-type, N-terminal | RNA_pol_30_chordopoxvir-type_N | 2 |
IPR024396 | 24,396 | Conjugal transfer protein TrbD, putative | Conjug_TrbD_put | Family | 340 | false | false | Members of this protein family are annotated as conjugal transfer protein TrbD; however, currently no function is known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10894"
] | [
"DUF2689"
] | [
340
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
340
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Conjugal transfer protein TrbD, putative | Conjugal transfer protein TrbD, putative | Conjug_TrbD_put | 6 |
IPR024397 | 24,397 | Poxvirus poly(A) polymerase, catalytic subunit, C-terminal | Poxvirus_polyA_pol_cat_C | Domain | 152 | false | false | Poly(A) polymerase ( ) catalyses template-independent extension of the 3'-end of a DNA or RNA strand by one nucleotide at a time. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heterodimer of a catalytic and a regulatory subunit. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heter... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12629"
] | [
"Pox_polyA_pol_C"
] | [
152
] | 1 | [
"EC"
] | [
"2.7.7.19"
] | [
"EC:2.7.7.19"
] | 1 | [
"2ga9",
"2gaf",
"3er8",
"3er9",
"3erc",
"3owg"
] | 6 | [
"PUB00040980"
] | [
"16678106"
] | [
"Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
152
] | 1 | [] | [] | 0 | true | Domain | Poxvirus poly(A) polymerase, catalytic subunit, C-terminal | Poxvirus poly(A) polymerase, catalytic subunit, C-terminal | Poxvirus_polyA_pol_cat_C | 2 |
IPR024398 | 24,398 | Poxvirus poly(A) polymerase, catalytic subunit, N-terminal | Poxvirus_polyA_pol_cat_N | Domain | 151 | false | false | Poly(A) polymerase ( ) catalyses template-independent extension of the 3'-end of a DNA or RNA strand by one nucleotide at a time. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heterodimer of a catalytic and a regulatory subunit. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heter... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12630"
] | [
"Pox_polyA_pol_N"
] | [
151
] | 1 | [
"EC"
] | [
"2.7.7.19"
] | [
"EC:2.7.7.19"
] | 1 | [
"2ga9",
"2gaf",
"3er8",
"3er9",
"3erc",
"3owg"
] | 6 | [
"PUB00040980"
] | [
"16678106"
] | [
"Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
151
] | 1 | [] | [] | 0 | true | Domain | Poxvirus poly(A) polymerase, catalytic subunit, N-terminal | Poxvirus poly(A) polymerase, catalytic subunit, N-terminal | Poxvirus_polyA_pol_cat_N | 4 |
IPR024399 | 24,399 | Domain of unknown function DUF2628 | DUF2628 | Domain | 3,797 | false | false | This entry represents a domain of unknown function in YigF and similar proteins. Their function is currently unknown. This domain is all helical. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10947"
] | [
"DUF2628"
] | [
3797
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
3764,
7,
25,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF2628 | Domain of unknown function DUF2628 | DUF2628 | 2 |
IPR024400 | 24,400 | Protein of unknown function DUF2635 | DUF2635 | Family | 1,551 | false | false | This family consists of uncharacterised proteins found in bacteria and bacteriophages. It includes protein Gp38 from Enterobacteria phage Mu. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10948"
] | [
"DUF2635"
] | [
1551
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5",
"Caudoviricetes",
"metagenomes"
] | [
1532,
1,
10,
8
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF2635 | Protein of unknown function DUF2635 | DUF2635 | 8 |
IPR024401 | 24,401 | WYL domain containing protein | WYL_prot | Family | 946 | false | false | This entry represents a group of WYL domain containing proteins. WYL is named for three conserved amino acids found in a subset of domains of this superfamily. These residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10902"
] | [
"WYL_2"
] | [
946
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085051"
] | [
"24817877"
] | [
"CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Haemonchus placei",
"Viruses",
"metagenomes"
] | [
575,
1,
357,
13
] | 4 | [] | [] | 0 | true | Family | WYL domain containing protein | WYL domain containing protein | WYL_prot | 9 |
IPR024402 | 24,402 | Domain of unknown function DUF2726 | DUF2726 | Domain | 4,648 | false | false | This domain found in bacterial proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10881"
] | [
"DUF2726"
] | [
4648
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcinaceae",
"Viruses",
"unclassified sequences"
] | [
4576,
2,
3,
13,
54
] | 5 | [] | [] | 0 | true | Domain | Domain of unknown function DUF2726 | Domain of unknown function DUF2726 | DUF2726 | 5 |
IPR024403 | 24,403 | Dihydroorotase, catalytic domain | DHOase_cat | Domain | 19,027 | false | false | This entry represents the catalytic domain found in the family of bacterial dihydroorotases. It also includes domains which are found in the multifunctional proteins r and pyr1-3 from Drosophila melanogaster and Dictyostelium discoideum, possessing dihydroorotase activity. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12890"
] | [
"DHOase"
] | [
19027
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"3.5.2.3",
"PWY-5686",
"PWY-7790",
"PWY-7791",
"R-DDI-500753",
"R-DME-500753"
] | [
"EC:3.5.2.3",
"METACYC:PWY-5686",
"METACYC:PWY-7790",
"METACYC:PWY-7791",
"REACTOME:R-DDI-500753",
"REACTOME:R-DME-500753"
] | 6 | [
"1xrf",
"1xrt",
"2z00",
"3d6n",
"3gri",
"3mpg",
"4bjh",
"4yiw",
"6gdd",
"6gde",
"6gdf"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Homavirus sp.",
"unclassified sequences"
] | [
85,
17403,
1045,
1,
493
] | 5 | [
"Danio rerio",
"Drosophila melanogaster"
] | [
4,
5
] | 2 | true | Domain | Dihydroorotase, catalytic domain | Dihydroorotase, catalytic domain | DHOase_cat | 9 |
IPR024404 | 24,404 | Lipid-binding, putative | Lipid-bd_put | Family | 313 | false | false | This entry represents a small family of uncharacterised proteins found in Bacteroidetes that may be involved in lipid binding. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12888"
] | [
"Lipid_bd"
] | [
313
] | 1 | [] | [] | [] | 0 | [
"3h3i",
"5fq6",
"5fq7",
"5fq8"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"metagenomes"
] | [
306,
7
] | 2 | [] | [] | 0 | true | Family | Lipid-binding, putative | Lipid-binding, putative | Lipid-bd_put | 9 |
IPR024405 | 24,405 | Prophage protein BhlA/UviB | Phage_BhlA/UviB | Family | 860 | false | false | BhlA is a SP-beta prophage-derived protein found in Bacillus subtilis [ , ] and other Bacilli. A related protein, UviB, has also been described in Clostridia, where it is believed to be involved in bacteriocin secretion or immunity [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10960"
] | [
"Holin_BhlA"
] | [
860
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044553",
"PUB00056177",
"PUB00056178",
"PUB00056179"
] | [
"10376821",
"2901768",
"2460717",
"9579063"
] | [
"Nucleotide sequence of the Bacillus subtilis temperate bacteriophage SPbetac2.",
"Complete nucleotide sequence and genetic organization of the bacteriocinogenic plasmid, pIP404, from Clostridium perfringens.",
"Studies of UV-inducible promoters from Clostridium perfringens in vivo and in vitro.",
"The N-acet... | [
1999,
1988,
1988,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)",
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
1,
791,
60,
8
] | 4 | [] | [] | 0 | true | Family | Prophage protein BhlA/UviB | Prophage protein BhlA/UviB | Phage_BhlA/UviB | 7 |
IPR024406 | 24,406 | Phage tail assembly chaperone TAC-10 | TAC-10 | Family | 855 | false | false | This is a family of phage tail assembly chaperone proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10963"
] | [
"Phage_TAC_10"
] | [
855
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075454"
] | [
"23542344"
] | [
"A conserved spiral structure for highly diverged phage tail assembly chaperones."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Capitella teleta",
"Caudoviricetes",
"metagenomes"
] | [
825,
2,
25,
3
] | 4 | [] | [] | 0 | true | Family | Phage tail assembly chaperone TAC-10 | Phage tail assembly chaperone TAC-10 | TAC-10 | 7 |
IPR024407 | 24,407 | Protein 3a, betacoronavirus | Protein_3a_bCoV | Family | 615 | false | false | Coronavirus encodes two viroporins, E protein and protein 3a, which act as ion-conductive pores in planar lipid bilayers and are required for maximal SARS-CoV replication and virulence [ ]. In betacoronavirus, this protein plays a role in viral egress via lysosomal trafficking [ , ]. Protein 3a from SARS-CoV-2 also blo... | [
"GO:0005216"
] | [
"monoatomic ion channel activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF11289",
"cd21648"
] | [
"bCoV_viroporin",
"SARS-CoV-like_ORF3a"
] | [
615,
493
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9678110",
"R-HSA-9679509",
"R-HSA-9683673",
"R-HSA-9683701",
"R-HSA-9686347",
"R-HSA-9692913",
"R-HSA-9692916",
"R-HSA-9694322",
"R-HSA-9694614",
"R-HSA-9694635",
"R-HSA-9694719",
"R-HSA-9705671",
"R-HSA-9733458",
"R-HSA-9735871",
"R-HSA-9754560",
"R-HSA-9755779"
] | [
"REACTOME:R-HSA-9678110",
"REACTOME:R-HSA-9679509",
"REACTOME:R-HSA-9683673",
"REACTOME:R-HSA-9683701",
"REACTOME:R-HSA-9686347",
"REACTOME:R-HSA-9692913",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9694322",
"REACTOME:R-HSA-9694614",
"REACTOME:R-HSA-9694635",
"REACTOME:R-HSA-9694719",
"REACTOM... | 16 | [
"6xdc",
"7kjr",
"8eqj",
"8eqs",
"8eqt",
"8equ"
] | 6 | [
"PUB00056030",
"PUB00056031",
"PUB00056032",
"PUB00075660",
"PUB00075661",
"PUB00075662",
"PUB00094124",
"PUB00094125",
"PUB00097963",
"PUB00097964",
"PUB00100499"
] | [
"16014971",
"16474139",
"16894145",
"15135062",
"15781262",
"20020050",
"31034780",
"32156572",
"33422265",
"33157038",
"34158638"
] | [
"The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells.",
"Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M.",
"Severe acute respiratory syndrome-associated coronavirus 3a protein f... | [
2005,
2006,
2006,
2004,
2005,
2009,
2019,
2020,
2021,
2020,
2021
] | 11 | [] | [] | 0 | 0 | null | [
"Orthocoronavirinae"
] | [
615
] | 1 | [] | [] | 0 | true | Family | Protein 3a, betacoronavirus | Protein 3a, betacoronavirus | Protein_3a_bCoV | 6 |
IPR024408 | 24,408 | N-acetylmuramidase | Muramidase | Domain | 2,242 | false | false | This domain is found in proteins from bacteria and viruses. It is found C-terminal in a novel Salmonella bacteriophage endolysin, where it has been shown to be responsible for its N-acetylmuramidase (lysozyme) activity [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11860"
] | [
"Muramidase"
] | [
2242
] | 1 | [] | [] | [] | 0 | [
"5nm7",
"7q4s",
"7q4t",
"7rum"
] | 4 | [
"PUB00081896"
] | [
"27287318"
] | [
"DUF3380 Domain from a Salmonella Phage Endolysin Shows Potent N-Acetylmuramidase Activity."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1948,
3,
275,
16
] | 4 | [] | [] | 0 | true | Domain | N-acetylmuramidase | N-acetylmuramidase | Muramidase | 3 |
IPR024409 | 24,409 | Protein of unknown function DUF3833 | DUF3833 | Family | 3,566 | false | false | This is a family of uncharacterised proteins found in Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12915"
] | [
"DUF3833"
] | [
3566
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Diploscapter pachys",
"unclassified sequences"
] | [
3542,
1,
23
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3833 | Protein of unknown function DUF3833 | DUF3833 | 1 |
IPR024410 | 24,410 | Phage tail assembly chaperone protein, TAC | Phage_TAC_12 | Family | 1,455 | false | false | This is a family of phage tail assembly chaperone proteins from Siphoviridae phages. TACs are required for the morphogenesis of all long-tailed phages. The proposed function for the TAC is to coat the tape-measure protein to prevent it from forming unproductive complexes or precipitating before the tail tube protein ha... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PIRSF"
] | [
"PF12363",
"PF16459",
"PF16462",
"PIRSF024865"
] | [
"Phage_TAC_12",
"Phage_TAC_13",
"Phage_TAC_14",
"UCP024865"
] | [
876,
420,
159,
102
] | 4 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075454"
] | [
"23542344"
] | [
"A conserved spiral structure for highly diverged phage tail assembly chaperones."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
1248,
203,
4
] | 3 | [] | [] | 0 | true | Family | Phage tail assembly chaperone protein, TAC | Phage tail assembly chaperone protein, TAC | Phage_TAC_12 | 3 |
IPR024411 | 24,411 | Tail terminator, bacteriophage | Tail_terminator_phage | Family | 1,174 | false | false | This entry represents a family of likely phage tail termination proteins which form a hexameric ring that connects the phage neck to the tail. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12691"
] | [
"Phage_tail_terminator_6"
] | [
1174
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanosarcina mazei",
"Viruses",
"metagenomes"
] | [
1011,
1,
119,
43
] | 4 | [] | [] | 0 | true | Family | Tail terminator, bacteriophage | Tail terminator, bacteriophage | Tail_terminator_phage | 3 |
IPR024412 | 24,412 | Lsr2 dimerization domain | Lsr2_dim_dom | Domain | 8,069 | false | false | This entry represents the dimerization domain found at the N-terminal of Lsr2. Lsr2 dimers show a self-associative propensity allowing chromosome compaction and gene regulation in response to external stress [ ]. Lsr2 is a small, basic DNA-binding protein present in Mycobacterium and related actinomycetes that regulate... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11774"
] | [
"Lsr2"
] | [
8069
] | 1 | [] | [] | [] | 0 | [
"4e1p",
"4e1r"
] | 2 | [
"PUB00056035",
"PUB00056036",
"PUB00065750",
"PUB00092826"
] | [
"18776007",
"17046956",
"22719899",
"20133735"
] | [
"Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins.",
"Escherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymerase.",
"The structure of the oligomerization domain of Lsr2 from Mycobacterium tuberculosis reveals a mechanism fo... | [
2008,
2006,
2012,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
7895,
9,
152,
13
] | 4 | [] | [] | 0 | true | Domain | Lsr2 dimerization domain | Lsr2 dimerization domain | Lsr2_dim_dom | 9 |
IPR024414 | 24,414 | Uncharacterised protein family PrgI | Uncharacterised_PrgI | Family | 4,864 | false | false | This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 116 and 146 amino acids in length. PrgI is found encoded on plasmids of Enterococcus faecalis, its function is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12666"
] | [
"PrgI"
] | [
4864
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Siphoviridae sp. ctoWO12",
"unclassified sequences"
] | [
3,
4807,
1,
53
] | 4 | [] | [] | 0 | true | Family | Uncharacterised protein family PrgI | Uncharacterised protein family PrgI | Uncharacterised_PrgI | 9 |
IPR024415 | 24,415 | Fungus-induced protein | Fungus-induced | Family | 67 | false | false | This entry represents fungus-induced proteins which may have role in hypoxia response [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10917"
] | [
"Fungus-induced"
] | [
67
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056206"
] | [
"15781453"
] | [
"Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
67
] | 1 | [
"Caenorhabditis elegans"
] | [
9
] | 1 | true | Family | Fungus-induced protein | Fungus-induced protein | Fungus-induced | 9 |
IPR024417 | 24,417 | Neuronal protein 3.1 | Neuronal_3.1 | Family | 542 | false | false | Neuronal protein 3.1, also known as P311, is found in neurone and muscle cells [ ]. It contains a conserved PEST (Pro, Glu, Ser, and Thr) motif, which is involved in protein-protein interactions, as well as in targeting proteins for degradation by the ubiquitin/proteasome system. In addition to a potential role in neur... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF11092",
"PTHR17102"
] | [
"Alveol-reg_P311",
""
] | [
542,
507
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056040",
"PUB00056041",
"PUB00056042"
] | [
"12417574",
"16484684",
"16229809"
] | [
"P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.",
"Identification of P311 as a potential gene regulating alveolar generation.",
"Regulation of glioma cell migration by serine-phosphorylated P311."
] | [
2002,
2006,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
542
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2
] | 3 | true | Family | Neuronal protein 3.1 | Neuronal protein 3.1 | Neuronal_3.1 | 3 |
IPR024419 | 24,419 | Protein of unknown function YvrJ | YvrJ | Family | 2,263 | false | false | This entry is represents a family of uncharacterised protein. The function of the Bacillus subtilis YvrJ protein is not known, but its expression is regulated by the cell envelope stress-inducible sigma factor YvrI [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12841"
] | [
"YvrJ"
] | [
2263
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056157"
] | [
"18573182"
] | [
"A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillus phage DLc1",
"Bacteria",
"metagenomes"
] | [
1,
2228,
34
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function YvrJ | Protein of unknown function YvrJ | YvrJ | 3 |
IPR024420 | 24,420 | TRAPP III complex, Trs85 | TRAPP_III_complex_Trs85 | Family | 6,114 | false | false | This entry represents Trs85, a subunit of the TRAPP III complex [ ]. Trs85 is a multimeric guanine nucleotide-exchange factor for Ypt1, required for membrane expansion during autophagy and the CVT pathway. It directs Ypt1 to the phagophore assembly site [ , , , ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12739",
"PTHR12975"
] | [
"TRAPPC-Trs85",
""
] | [
5340,
6062
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8876198",
"R-HSA-8876198",
"R-SPO-8876198"
] | [
"REACTOME:R-CEL-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-SPO-8876198"
] | 3 | [
"7b6e",
"7b6r",
"7b6y",
"7b70",
"7kmt"
] | 5 | [
"PUB00056043",
"PUB00056044",
"PUB00056045",
"PUB00056046",
"PUB00056047"
] | [
"20375281",
"16079147",
"9504908",
"8619313",
"16874038"
] | [
"Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.",
"Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.",
"Yeast meiotic mutants proficient for the induction of ectopic r... | [
2010,
2005,
1998,
1995,
2005
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6114
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
2,
5,
3,
8,
8,
1,
5,
5,
1,
2,
6
] | 12 | true | Family | TRAPP III complex, Trs85 | TRAPP III complex, Trs85 | TRAPP_III_complex_Trs85 | 5 |
IPR024421 | 24,421 | Bacteriophage P22, Mnt | Phage_P22_Mnt | Family | 153 | false | false | Mnt is a repressor which is involved in the genetic switch between lysogenic and lytic growth in bacteriophage P22. The C-terminal domain of the protein consists of a dimer of two antiparallel coiled coils with a right handed twist, which is both stronger and has closer inter-helical separation compared with those foun... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11423"
] | [
"Repressor_Mnt"
] | [
153
] | 1 | [] | [] | [] | 0 | [
"1mnt",
"1qey"
] | 2 | [
"PUB00030227"
] | [
"10426954"
] | [
"The tetramerization domain of the Mnt repressor consists of two right-handed coiled coils."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Enterobacterales"
] | [
9,
144
] | 2 | [] | [] | 0 | true | Family | Bacteriophage P22, Mnt | Bacteriophage P22, Mnt | Phage_P22_Mnt | 1 |
IPR024422 | 24,422 | Protein of unknown function, OB-fold-containing | Protein_unknown_function_OB | Family | 1,310 | false | false | The function of the proteins in this entry is not known, but they contain a novel variant of the nucleic acid-binding OB fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12869"
] | [
"tRNA_anti-like"
] | [
1310
] | 1 | [] | [] | [] | 0 | [
"3f1z"
] | 1 | [
"PUB00056169"
] | [
"20944219"
] | [
"The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"ecological metagenomes"
] | [
9,
1260,
13,
3,
25
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function, OB-fold-containing | Protein of unknown function, OB-fold-containing | Protein_unknown_function_OB | 1 |
IPR024423 | 24,423 | Protein of unknown function DUF3050 | DUF3050 | Family | 2,358 | false | false | This family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11251"
] | [
"DUF3050"
] | [
2358
] | 1 | [] | [] | [] | 0 | [
"9vwb"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
2287,
1,
57,
4,
9
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function DUF3050 | Protein of unknown function DUF3050 | DUF3050 | 3 |
IPR024424 | 24,424 | Replicative helicase inhibitor G39P, N-terminal | G39P_N | Domain | 200 | false | false | G39P inhibits the initiation of DNA replication by blocking G40P replicative helicase. G39P has a bipartite structure consisting of a folded N-terminal domain and an unfolded C-terminal domain. The C-terminal domain is essential for helicase interaction [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11417"
] | [
"G39P_N"
] | [
200
] | 1 | [] | [] | [] | 0 | [
"1no1"
] | 1 | [
"PUB00029156"
] | [
"12588876"
] | [
"Structural analysis of Bacillus subtilis SPP1 phage helicase loader protein G39P."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
182,
18
] | 2 | [] | [] | 0 | true | Domain | Replicative helicase inhibitor G39P, N-terminal | Replicative helicase inhibitor G39P, N-terminal | G39P_N | 1 |
IPR024425 | 24,425 | Cell wall-active antibiotics response LiaF-like, C-terminal | LiaF-like_C | Domain | 6,282 | false | false | This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, LiaF, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus [ ]. This domain has been described as T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09922"
] | [
"LiaF-like_C"
] | [
6282
] | 1 | [] | [] | [] | 0 | [
"4qrk"
] | 1 | [
"PUB00075646"
] | [
"19889788"
] | [
"Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF/VraSR."
] | [
2010
] | 1 | [] | [
"IPR047793"
] | 0 | 1 | 0 | [
"Bacteria",
"Methanobacteriota",
"Symbiodiniaceae",
"metagenomes"
] | [
6216,
20,
2,
44
] | 4 | [] | [] | 0 | true | Domain | Cell wall-active antibiotics response LiaF-like, C-terminal | Cell wall-active antibiotics response LiaF-like, C-terminal | LiaF-like_C | 8 |
IPR024426 | 24,426 | Protein of unknown function DUF2694 | DUF2694 | Family | 203 | false | false | This family of proteins with unknown function appears to be restricted to Mycobacterium spp. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10904"
] | [
"DUF2694"
] | [
203
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycobacteriaceae"
] | [
203
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2694 | Protein of unknown function DUF2694 | DUF2694 | 6 |
IPR024427 | 24,427 | Endosialidase, beta-barrel domain | B-barrel_Endosialidase | Domain | 56 | false | false | This entry represents the β-barrel domain of endosialidases which is nested in a β-propeller domain. This β-barrel domain is approximately 80 amino acids in length and represents one of the two sialic acid binding sites of the enzyme [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12195"
] | [
"End_beta_barrel"
] | [
56
] | 1 | [] | [] | [] | 0 | [
"1v0e",
"1v0f",
"3gvj",
"3gvk",
"3gvl",
"3ju4",
"4hiz"
] | 7 | [
"PUB00037909",
"PUB00082574"
] | [
"15608653",
"20096705"
] | [
"Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.",
"Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"Viruses"
] | [
18,
38
] | 2 | [] | [] | 0 | true | Domain | Endosialidase, beta-barrel domain | Endosialidase, beta-barrel domain | B-barrel_Endosialidase | 4 |
IPR024428 | 24,428 | Endosialidase, beta-propeller domain | Endosialidase_beta_prop | Domain | 64 | false | false | This entry represents the β propeller domain of endosialidases, which consists of catalytically active part of the enzymes. This core domain forms stable SDS-resistant trimers. There is a nested β barrel domain in this domain. This domain is typically between 443 and 460 amino acids in length [ , ]. | [
"GO:0016996"
] | [
"endo-alpha-(2,8)-sialidase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12217"
] | [
"End_beta_propel"
] | [
64
] | 1 | [] | [] | [] | 0 | [
"1v0e",
"1v0f",
"3gvj",
"3gvk",
"3gvl",
"3ju4",
"4hiz"
] | 7 | [
"PUB00037909",
"PUB00082574"
] | [
"15608653",
"20096705"
] | [
"Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.",
"Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Viruses"
] | [
25,
39
] | 2 | [] | [] | 0 | true | Domain | Endosialidase, beta-propeller domain | Endosialidase, beta-propeller domain | Endosialidase_beta_prop | 8 |
IPR024429 | 24,429 | Endosialidase, N-terminal extension domain | Endosialidase_N-extension | Domain | 71 | false | false | This entry represents the N-terminal extension domain of endosialidases which is approximately 70 amino acids in length. The two N-terminal domains (this domain and the β propeller) assemble in the compact 'cap' whereas the C-terminal domain forms an extended tail-like structure. The very N-terminal part of the 'cap' r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12218"
] | [
"End_N_terminal"
] | [
71
] | 1 | [] | [] | [] | 0 | [
"1v0e",
"1v0f",
"3gvj",
"3gvk",
"3gvl",
"3ju4",
"4hiz"
] | 7 | [
"PUB00037909"
] | [
"15608653"
] | [
"Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
31,
40
] | 2 | [] | [] | 0 | true | Domain | Endosialidase, N-terminal extension domain | Endosialidase, N-terminal extension domain | Endosialidase_N-extension | 5 |
IPR024430 | 24,430 | Endosialidase, C-terminal domain | Endosialidase_C_dom | Domain | 62 | false | false | This entry represents the C-terminal domain of endosialidase, which is approximately 160 amino acids in length. There are two conserved sequence motifs: VSR and YGA. The endosialidase protein forms homotrimeric molecules and this domain complexes into a tail-spike stalk. The stalk region folds in a triple β-helix that ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12219"
] | [
"End_tail_spike"
] | [
62
] | 1 | [] | [] | [] | 0 | [
"1v0e",
"1v0f",
"3gvj",
"3gvk",
"3gvl",
"3gw6",
"3ju4",
"4hiz"
] | 8 | [
"PUB00037909"
] | [
"15608653"
] | [
"Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Viruses"
] | [
21,
41
] | 2 | [] | [] | 0 | true | Domain | Endosialidase, C-terminal domain | Endosialidase, C-terminal domain | Endosialidase_C_dom | 3 |
IPR024431 | 24,431 | Insertion element IS1 protein InsA, helix-turn-helix domain | InsA_HTH_dom | Domain | 2,520 | false | false | This entry represents the helix-turn-helix domain found at the C-terminal of InsA. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12759"
] | [
"HTH_Tnp_IS1"
] | [
2520
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Punavirus",
"Stylonychia lemnae",
"metagenomes"
] | [
2481,
3,
1,
35
] | 4 | [
"Escherichia coli (strain K12)"
] | [
9
] | 1 | true | Domain | Insertion element IS1 protein InsA, helix-turn-helix domain | Insertion element IS1 protein InsA, helix-turn-helix domain | InsA_HTH_dom | 5 |
IPR024432 | 24,432 | Putative exodeoxyribonuclease 8, PDDEXK-like domain | Put_RecE_PDDEXK-like_dom | Domain | 3,441 | false | false | This entry represents a PDDEXK-like domain of unknown function found in proteins from bacteria and viruses. Many of these proteins are annotated as exodeoxyribonuclease 8, which is involved in the RecE pathway of recombination. The PD-(D/E)XK domain is ubiquitously found in enzymes involved in metabolism of nucleic aci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12684"
] | [
"DUF3799"
] | [
3441
] | 1 | [] | [] | [] | 0 | [
"3h4r",
"3l0a"
] | 2 | [
"PUB00035699"
] | [
"15720711"
] | [
"Identification of a new family of putative PD-(D/E)XK nucleases with unusual phylogenomic distribution and a new type of the active site."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2784,
8,
583,
66
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Putative exodeoxyribonuclease 8, PDDEXK-like domain | Putative exodeoxyribonuclease 8, PDDEXK-like domain | Put_RecE_PDDEXK-like_dom | 4 |
IPR024434 | 24,434 | TSCPD domain | TSCPD_dom | Domain | 12,022 | false | false | The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD, after which the domain is named. Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulphur cluster. This domain is found at the C-terminal of some ribonucleoside-diphosphate reductase enz... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12637"
] | [
"TSCPD"
] | [
12022
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.17.4.1",
"PWY-6545",
"PWY-7184",
"PWY-7198",
"PWY-7210",
"PWY-7220",
"PWY-7222",
"PWY-7226",
"PWY-7227"
] | [
"EC:1.17.4.1",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"METACYC:PWY-7220",
"METACYC:PWY-7222",
"METACYC:PWY-7226",
"METACYC:PWY-7227"
] | 9 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
427,
11028,
30,
11,
526
] | 5 | [] | [] | 0 | true | Domain | TSCPD domain | TSCPD domain | TSCPD_dom | 6 |
IPR024435 | 24,435 | Histidyl tRNA synthetase-related domain | HisRS-related_dom | Domain | 3,859 | false | false | This entry represents the histidyl-tRNA synthetase-related (HisRS-related) domain, found largely in Gcn2 protein kinases [ ]. In yeast, Gcn2 phosphorylates the alpha subunit of eukaryotic initiation factor-2 (eIF-2) when the cells face the starvation for amino acids. The HisRS-related domain is required for activation ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12745"
] | [
"HGTP_anticodon2"
] | [
3859
] | 1 | [
"EC",
"REACTOME"
] | [
"2.7.11.1",
"R-HSA-9633012"
] | [
"EC:2.7.11.1",
"REACTOME:R-HSA-9633012"
] | 2 | [
"4otm",
"8t7t",
"9bf3",
"9c9q",
"9c9r",
"9f58"
] | 6 | [
"PUB00056048",
"PUB00062021",
"PUB00063768"
] | [
"1739968",
"10655230",
"8798780"
] | [
"Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.",
"A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.",
"Histidyl-tRNA synthetase-related s... | [
1992,
2000,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3859
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
8,
4,
2,
4,
1,
3,
6,
1,
1,
12
] | 10 | true | Domain | Histidyl tRNA synthetase-related domain | Histidyl tRNA synthetase-related domain | HisRS-related_dom | 4 |
IPR024436 | 24,436 | Domain of unknown function DUF3824 | DUF3824 | Domain | 851 | false | false | This repeating domain is proline-rich but its function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12868"
] | [
"DUF3824"
] | [
851
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
20,
831
] | 2 | [
"Zea mays"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF3824 | Domain of unknown function DUF3824 | DUF3824 | 2 |
IPR024437 | 24,437 | Domain of unknown function DUF3825 | DUF3825 | Domain | 495 | false | false | This uncharacterised domain has conserved residues suggestive of an enzymatic role probably related to RNA metabolism. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12873"
] | [
"DUF3825"
] | [
495
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
427,
51,
6,
11
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3825 | Domain of unknown function DUF3825 | DUF3825 | 7 |
IPR024438 | 24,438 | Staygreen protein | Staygreen | Domain | 2,158 | false | false | This domain is found in a family of proteins have been implicated in chlorophyll degradation [ , ]. Intriguingly members of this family are also found in non-photosynthetic bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12638"
] | [
"Staygreen"
] | [
2158
] | 1 | [] | [] | [] | 0 | [
"7y5y"
] | 1 | [
"PUB00044593",
"PUB00056049"
] | [
"17513504",
"17468209"
] | [
"The senescence-induced staygreen protein regulates chlorophyll degradation.",
"Identification of a novel chloroplast protein AtNYE1 regulating chlorophyll degradation during leaf senescence in Arabidopsis."
] | [
2007,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Viridiplantae",
"bioreactor metagenome",
"miscellaneous Crenarchaeota group-1 archaeon SG8-32-1"
] | [
578,
1572,
7,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
3,
13
] | 3 | true | Domain | Staygreen protein | Staygreen protein | Staygreen | 5 |
IPR024439 | 24,439 | RNHCP domain | RNHCP | Domain | 1,712 | false | false | This domain is found in uncharacterised bacterial proteins. It is typically between 94 and 143 amino acids in length and has a conserved RNHCP sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12647"
] | [
"RNHCP"
] | [
1712
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Micrarchaeota",
"Octactis speculum",
"metagenomes"
] | [
1694,
2,
1,
15
] | 4 | [] | [] | 0 | true | Domain | RNHCP domain | RNHCP domain | RNHCP | 9 |
IPR024440 | 24,440 | Colicin D, C-terminal | ColicinD_C | Domain | 350 | false | false | Colicin D is a bacteriocin that kills target cells by cleaving tRNA(Arg). This entry represents a domain found in the C terminus of colicin D, which is responsible for its catalytic activity [ ]. The domain is also found in some S-type pyocins, which are also bacteriocins. | [
"GO:0004540"
] | [
"RNA nuclease activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11429"
] | [
"Colicin_D"
] | [
350
] | 1 | [] | [] | [] | 0 | [
"1tfk",
"1tfo",
"1v74",
"5znm"
] | 4 | [
"PUB00031440"
] | [
"15336558"
] | [
"Relation between tRNase activity and the structure of colicin D according to X-ray crystallography."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Fungi",
"Stenosarchaea group",
"bioreactor metagenome"
] | [
286,
48,
15,
1
] | 4 | [] | [] | 0 | true | Domain | Colicin D, C-terminal | Colicin D, C-terminal | ColicinD_C | 6 |
IPR024441 | 24,441 | Mating-type protein, C-terminal domain | Homeodomain1_C | Domain | 177 | false | false | Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12737"
] | [
"Mating_C"
] | [
177
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
177
] | 1 | [] | [] | 0 | true | Domain | Mating-type protein, C-terminal domain | Mating-type protein, C-terminal domain | Homeodomain1_C | 2 |
IPR024442 | 24,442 | Transposase, zinc-ribbon | Transposase_Zn_ribbon | Domain | 4,607 | false | false | This zinc binding domain is found in a range of transposase proteins such as ISSPO8, ISSOD11, ISRSSP2 etc. It may be a zinc-binding β-ribbon domain that could bind DNA. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12760"
] | [
"Zn_ribbon_IS1595"
] | [
4607
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
250,
4155,
12,
14,
176
] | 5 | [] | [] | 0 | true | Domain | Transposase, zinc-ribbon | Transposase, zinc-ribbon | Transposase_Zn_ribbon | 5 |
IPR024444 | 24,444 | Protein of unknown function DUF2706 | DUF2706 | Family | 42 | false | false | This family of proteins with unknown function appears to be restricted to Rickettsia spp. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10913"
] | [
"DUF2706"
] | [
42
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rickettsiaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2706 | Protein of unknown function DUF2706 | DUF2706 | 2 |
IPR024445 | 24,445 | ISXO2-like transposase domain | Tnp_ISXO2-like | Domain | 12,207 | false | false | This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF12762",
"SM01126"
] | [
"DDE_Tnp_IS1595",
"DDE_Tnp_IS1595"
] | [
11787,
10433
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
387,
7414,
3971,
434,
1
] | 5 | [
"Danio rerio"
] | [
10
] | 1 | true | Domain | ISXO2-like transposase domain | ISXO2-like transposase domain | Tnp_ISXO2-like | 8 |
IPR024446 | 24,446 | PXPV repeat | PXPV | Repeat | 512 | false | false | This short repeat is found in multiple copies in a variety of proteins predominantly found in proteobacteria. The function of this region is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12778"
] | [
"PXPV"
] | [
512
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
17,
495
] | 2 | [] | [] | 0 | true | Repeat | PXPV repeat | PXPV repeat | PXPV | 6 |
IPR024448 | 24,448 | Xylosyltransferase, C-terminal | XylT_C | Domain | 3,062 | false | false | This domain is found in metazoan xylosyltransferases, which include xylosyltransferase 1 and xylosyltransferase 2. These enzymes initiate the biosynthesis of glycosaminoglycan chains in proteoglycans by transferring xylose from UDP-xylose to specific serine residues of the core protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12529"
] | [
"Xylo_C"
] | [
3062
] | 1 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.26",
"GenProp1699",
"PWY-6557",
"R-CFA-1971475",
"R-DME-1971475",
"R-HSA-1971475",
"R-MMU-1971475",
"R-RNO-1971475"
] | [
"EC:2.4.2.26",
"GP:GenProp1699",
"METACYC:PWY-6557",
"REACTOME:R-CFA-1971475",
"REACTOME:R-DME-1971475",
"REACTOME:R-HSA-1971475",
"REACTOME:R-MMU-1971475",
"REACTOME:R-RNO-1971475"
] | 8 | [
"6ej7",
"6ej8",
"6ej9",
"6eja",
"6ejb",
"6ejc",
"6ejd",
"6eje",
"6foa"
] | 9 | [
"PUB00056051"
] | [
"11099377"
] | [
"Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3062
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
5,
8,
7
] | 5 | true | Domain | Xylosyltransferase, C-terminal | Xylosyltransferase, C-terminal | XylT_C | 4 |
IPR024449 | 24,449 | Anti-sigma factor RsgI, N-terminal | Anti-sigma_RsgI_N | Domain | 1,741 | false | false | The heat shock genes in Bacillus subtilis can be classified into several groups according to their regulation [ ], and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes [ ]. Regulation of sigma factor I is carried out... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF12791",
"PS51849"
] | [
"RsgI_N",
"RSGI_N"
] | [
1655,
1717
] | 2 | [] | [] | [] | 0 | [
"6ivs",
"6ivu"
] | 2 | [
"PUB00034420",
"PUB00056050"
] | [
"11157964",
"17185538"
] | [
"Putative sigma factor SigI (YkoZ) of Bacillus subtilis is induced by heat shock.",
"Regulatory role of RsgI in sigI expression in Bacillus subtilis."
] | [
2001,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"metagenomes"
] | [
1732,
9
] | 2 | [] | [] | 0 | true | Domain | Anti-sigma factor RsgI, N-terminal | Anti-sigma factor RsgI, N-terminal | Anti-sigma_RsgI_N | 3 |
IPR024450 | 24,450 | Domain of unknown function DUF3874 | DUF3874 | Domain | 1,406 | false | false | This domain of unknown function if found in uncharacterised proteins from Bacteroides thetaiotaomicron and other Bacteroidetes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12990"
] | [
"DUF3874"
] | [
1406
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"metagenomes"
] | [
1384,
22
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3874 | Domain of unknown function DUF3874 | DUF3874 | 3 |
IPR024451 | 24,451 | TraG, N-terminal, Bacteroidetes | TraG_N_Bacteroidetes | Domain | 2,523 | false | false | This domain of unknown function is found in proteins from Bacteroidetes, including the conjugation system ATPase, TraG. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12991"
] | [
"DUF3875"
] | [
2523
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Tanacetum cinerariifolium",
"metagenomes"
] | [
2494,
1,
28
] | 3 | [] | [] | 0 | true | Domain | TraG, N-terminal, Bacteroidetes | TraG, N-terminal, Bacteroidetes | TraG_N_Bacteroidetes | 6 |
IPR024452 | 24,452 | Protein of unknown function DUF3876 | DUF3876 | Family | 915 | false | false | This bacterial family of conserved proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12992"
] | [
"DUF3876"
] | [
915
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
888,
27
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3876 | Protein of unknown function DUF3876 | DUF3876 | 5 |
IPR024453 | 24,453 | Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family | Peptidase_C92 | Family | 5,937 | false | false | Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered α-β fold with a central, 6-stranded, antiparallel β-sheet that is protected by helices on either s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05708"
] | [
"Peptidase_C92"
] | [
5937
] | 1 | [] | [] | [] | 0 | [
"2if6",
"3kw0"
] | 2 | [
"PUB00075488",
"PUB00103627"
] | [
"21799766",
"18281072"
] | [
"Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites.",
"A conserved poxvirus NlpC/P60 superfamily protein contributes to vaccinia virus virulence in mice but not to replication in cell culture."
] | [
2011,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
45,
5266,
365,
172,
89
] | 5 | [
"Caenorhabditis elegans",
"Escherichia coli (strain K12)"
] | [
1,
3
] | 2 | true | Family | Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family | Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family | Peptidase_C92 | 4 |
IPR024455 | 24,455 | Phage capsid | Phage_capsid | Family | 16,708 | false | false | The proteins in this family are found in bacteria and viruses (Caudovirales) and represent bacteriophage capsid proteins. The major capsid protein of Enterobacteria phage HK97 assembles to form an icosahedral capsid [ , ]. Included within the capsid protein is the delta domain which acts as the scaffold upon which the ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01554"
] | [
"major_cap_HK97"
] | [
16708
] | 1 | [
"GP"
] | [
"GenProp0208"
] | [
"GP:GenProp0208"
] | 1 | [
"1if0",
"1ohg",
"2frp",
"2fs3",
"2fsy",
"2ft1",
"2fte",
"2gp1",
"3ddx",
"3e8k",
"3j1a",
"3qpr",
"5tjt",
"6b0x",
"6b23",
"6c21",
"6c22",
"6okb",
"6oma",
"6omc",
"6tb9",
"6tba",
"6tsu",
"6tsw",
"6tui",
"7rwz",
"8cfa",
"8eb4",
"8ec2",
"8ec8",
"8eci",
"8ecj"... | 53 | [
"PUB00046522",
"PUB00065553",
"PUB00100782"
] | [
"11000116",
"21276801",
"34362927"
] | [
"Topologically linked protein rings in the bacteriophage HK97 capsid.",
"The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation.",
"Large-scale computational discovery and analysis of virus-derived microbial nanocompartments."
] | [
2000,
2011,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
17,
14033,
34,
2256,
368
] | 5 | [] | [] | 0 | true | Family | Phage capsid | Phage capsid | Phage_capsid | 5 |
IPR024457 | 24,457 | Putative integrase, N-terminal | Putative_integrase_N | Domain | 2,323 | false | false | Phage integrase proteins cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment [ , ]. This entry represents the N-terminal predicted α-helical domain found in a family of putative propha... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12834"
] | [
"Phage_int_SAM_2"
] | [
2323
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004261",
"PUB00005224"
] | [
"9288963",
"9082984"
] | [
"Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse.",
"Flexibility in DNA recombination: structure of the lambda integrase catalytic core."
] | [
1997,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Kochitakasuvirus",
"Opisthokonta",
"metagenomes"
] | [
2306,
2,
5,
10
] | 4 | [] | [] | 0 | true | Domain | Putative integrase, N-terminal | Putative integrase, N-terminal | Putative_integrase_N | 9 |
IPR024459 | 24,459 | Anti-CBASS protein Acb1-like, N-terminal domain | Acb1-like_N | Domain | 3,533 | false | false | This domain is found at the N-terminal end of Anti-CBASS protein Acb1 from Sphingomonas paeninsulae and similar sequences from tailed bacteriophages and bacterial prophages. Abc1 counteracts or regulates the endogenous CBASS (cyclic oligonucleotide-based antiphage signalling system) antiviral defence system. It is a ph... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF06381"
] | [
"Phage_portal_3"
] | [
3533
] | 1 | [] | [] | [] | 0 | [
"7kln",
"8fvh",
"8hds",
"8pho",
"8php",
"8phu",
"8qo0",
"8qo1",
"9b41",
"9jlf",
"9kmh",
"9l01",
"9yin"
] | 13 | [
"PUB00101341"
] | [
"35395152"
] | [
"Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"Viruses",
"metagenomes"
] | [
2818,
19,
24,
609,
63
] | 5 | [] | [] | 0 | true | Domain | Anti-CBASS protein Acb1-like, N-terminal domain | Anti-CBASS protein Acb1-like, N-terminal domain | Acb1-like_N | 8 |
IPR024460 | 24,460 | Protamine-like | Protamine-like | Family | 280 | false | false | This entry represent a group of insect proteins, including protamine A (ProtA), protamine B (ProtB) and protamine-like protein 99C (Prtl99C) from Drosophila melanogaster. They contain a HMG-box and are involved in chromatin compaction during spermiogenesis [ , ]. Prtl99C is a sperm chromatin-associated protein that is ... | [
"GO:0007283",
"GO:0035092"
] | [
"spermatogenesis",
"sperm DNA condensation"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF06382"
] | [
"Protamine_like"
] | [
280
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083890",
"PUB00083892"
] | [
"26673329",
"15988027"
] | [
"Prtl99C Acts Together with Protamines and Safeguards Male Fertility in Drosophila.",
"Replacement by Drosophila melanogaster protamines and Mst77F of histones during chromatin condensation in late spermatids and role of sesame in the removal of these proteins from the male pronucleus."
] | [
2015,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Halobacteriales",
"Lysinibacillus sphaericus",
"Opisthokonta"
] | [
2,
1,
277
] | 3 | [
"Drosophila melanogaster"
] | [
16
] | 1 | true | Family | Protamine-like | Protamine-like | Protamine-like | 3 |
IPR024461 | 24,461 | Coiled-coil domain-containing protein 90-like | CCDC90-like | Family | 7,509 | false | false | This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1 [ , , ]. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF07798",
"PTHR14360"
] | [
"CCDC90-like",
""
] | [
7427,
7060
] | 2 | [] | [] | [] | 0 | [
"6h9m"
] | 1 | [
"PUB00075452",
"PUB00076354",
"PUB00097799",
"PUB00097800",
"PUB00097801"
] | [
"25565209",
"23178883",
"27184846",
"26445506",
"26976564"
] | [
"CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.",
"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.",
"MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioener... | [
2015,
2012,
2016,
2015,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermocladium modestius",
"ecological metagenomes"
] | [
246,
7258,
1,
4
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
17,
3,
9,
2,
2,
2,
9,
2,
3,
9
] | 10 | true | Family | Coiled-coil domain-containing protein 90-like | Coiled-coil domain-containing protein 90-like | CCDC90-like | 2 |
IPR024462 | 24,462 | Glycosyl-hydrolase family 116, N-terminal | GH116_N | Domain | 6,196 | false | false | This entry represents the N-terminal domain found in the CAZyme GH116 family members, which presently includes enzymes with beta-glucosidase ( ), beta-xylosidase ( ) , and glucocerebrosidase ( ) activity [ , ]. The N-terminal is thought to be the luminal domain while the C-terminal is the cytosolic domain. Proteins con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12215"
] | [
"Glyco_hydr_116N"
] | [
6196
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
... | [
"2.4.1.-",
"3.2.1.-",
"3.2.1.45",
"3.2.1.46",
"PWY-1901",
"PWY-1921",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286"... | [
"EC:2.4.1.-",
"EC:3.2.1.-",
"EC:3.2.1.45",
"EC:3.2.1.46",
"METACYC:PWY-1901",
"METACYC:PWY-1921",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC... | 234 | [
"5bvu",
"5bx2",
"5bx3",
"5bx4",
"5bx5",
"5fjs",
"5npf",
"5o0s",
"5ost",
"7dks",
"7dkt",
"7dku",
"7dkv",
"7dkw",
"7dkx",
"7dky",
"7w2s",
"7w2t",
"7w2v",
"7w2w",
"7w2x",
"8i5o",
"8i5p",
"8i5q",
"8i5r",
"8i5s",
"8i5t",
"8i5u",
"8ic6",
"8ic7",
"8jbo",
"8r06"... | 33 | [
"PUB00044658",
"PUB00044659",
"PUB00073615",
"PUB00078737"
] | [
"17105727",
"17080196",
"20427274",
"23332917"
] | [
"Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.",
"Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.",
"A new archaeal beta-glycosidase from Sulfolobus solfataricus: seeding a novel retaining beta-glycan-specific glycoside hydrolase fami... | [
2007,
2006,
2010,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoprotei",
"unclassified sequences"
] | [
1530,
4524,
95,
47
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
32,
4,
1,
4,
3,
2,
14,
3,
33
] | 9 | true | Domain | Glycosyl-hydrolase family 116, N-terminal | Glycosyl-hydrolase family 116, N-terminal | GH116_N | 2 |
IPR024463 | 24,463 | Transposase TnpC, homeodomain | Transposase_TnpC_homeodom | Domain | 11,835 | false | false | This entry represents a leucine-zipper-like, or homeodomain-like, region of the transposase TnpC from insertion element IS66 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13007"
] | [
"LZ_Tnp_IS66"
] | [
11835
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011506"
] | [
"11418571"
] | [
"Structural and functional characterization of IS679 and IS66-family elements."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanosarcina mazei",
"metagenomes",
"plasmids"
] | [
11661,
8,
36,
2,
126,
2
] | 6 | [] | [] | 0 | true | Domain | Transposase TnpC, homeodomain | Transposase TnpC, homeodomain | Transposase_TnpC_homeodom | 7 |
IPR024464 | 24,464 | Protein of unknown function DUF2391 | DUF2391 | Family | 1,206 | false | false | Members of this protein family are found in archaea and bacteria. Their function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09622"
] | [
"DUF2391"
] | [
1206
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR013416"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
326,
877,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2391 | Protein of unknown function DUF2391 | DUF2391 | 4 |
IPR024465 | 24,465 | Domain of unknown function DUF2399 | DUF2399 | Domain | 1,975 | false | false | This domain is found in archaeal, bacterial and eukaryotic proteins. Its function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09664"
] | [
"DUF2399"
] | [
1975
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1967,
4,
4
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF2399 | Domain of unknown function DUF2399 | DUF2399 | 9 |
IPR024466 | 24,466 | Conserved hypothetical protein CHP02679, N terminus | CHP02679_N | Domain | 1,700 | false | false | This domain is found to the N terminus of bacterial conserved hypothetical proteins which are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11796"
] | [
"DUF3323"
] | [
1700
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Syncephalis pseudoplumigaleata",
"ecological metagenomes"
] | [
1697,
1,
2
] | 3 | [] | [] | 0 | true | Domain | Conserved hypothetical protein CHP02679, N terminus | Conserved hypothetical protein CHP02679, N terminus | CHP02679_N | 1 |
IPR024467 | 24,467 | Antitoxin Xre/MbcA/ParS-like, toxin-binding domain | Xre/MbcA/ParS-like_toxin-bd | Domain | 9,695 | false | false | This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp. [ , , , ]. This domain interacts with the toxin component (RES, MbcT and ParT respectively) and sterically blocks... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09722"
] | [
"Xre_MbcA_ParS_C"
] | [
9695
] | 1 | [] | [] | [] | 0 | [
"6d0h",
"6d0i",
"6fkg",
"6gw6",
"8gug",
"8qnl",
"8qnq",
"9r35"
] | 8 | [
"PUB00093678",
"PUB00098290",
"PUB00098291",
"PUB00098292"
] | [
"30315706",
"33384857",
"30792174",
"30598453"
] | [
"The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+",
"Bacterial type II toxin-antitoxin systems acting through post-translational modifications.",
"An NAD<sup>+</sup> Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.",
"ParST is a widespread toxin-... | [
2019,
2021,
2019,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
9589,
4,
8,
94
] | 4 | [
"Mus musculus"
] | [
1
] | 1 | true | Domain | Antitoxin Xre/MbcA/ParS-like, toxin-binding domain | Antitoxin Xre/MbcA/ParS-like, toxin-binding domain | Xre/MbcA/ParS-like_toxin-bd | 4 |
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