interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR024221 | 24,221 | Beta-lactamase-inhibitor protein BLIP domain superfamily | BLIP_dom_sf | Homologous_superfamily | 193 | false | false | This superfamily represents the structural domains of BLIP [ ]. The beta-lactamase-inhibitor protein (BLIP) is produced by Streptomyces species. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively to TEM-1 a... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF55648"
] | [
""
] | [
193
] | 1 | [] | [] | [] | 0 | [
"1jtg",
"1s0w",
"1xxm",
"2b5r",
"2g2u",
"2g2w",
"3c4o",
"3c4p",
"3c7u",
"3c7v",
"3e2k",
"3e2l",
"3gmu",
"3gmv",
"3gmw",
"3gmx",
"3gmy",
"3n4i",
"7s5s",
"9q0a",
"9q0b",
"9q0c"
] | 22 | [
"PUB00013170",
"PUB00013255",
"PUB00040912"
] | [
"8605632",
"11573088",
"16809340"
] | [
"A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.",
"Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.",
"Structural and computational characterization of the SHV-1 b... | [
1996,
2001,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctqw35"
] | [
134,
58,
1
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Beta-lactamase-inhibitor protein BLIP domain superfamily | Beta-lactamase-inhibitor protein BLIP domain superfamily | BLIP_dom_sf | 7 |
IPR024222 | 24,222 | CST complex subunit Ten1, fungal | Ten1_fungal | Family | 880 | false | false | Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length [ ]. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [ ]. These three interactin... | [
"GO:0043047",
"GO:0016233",
"GO:1990879"
] | [
"single-stranded telomeric DNA binding",
"telomere capping",
"CST complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF12658"
] | [
"Ten1"
] | [
880
] | 1 | [] | [] | [] | 0 | [
"3k0x",
"3kf6",
"3kf8"
] | 3 | [
"PUB00044503",
"PUB00045140",
"PUB00056135",
"PUB00066772"
] | [
"17293872",
"17715303",
"19884503",
"19854124"
] | [
"RPA-like proteins mediate yeast telomere function.",
"Protection of telomeres by a conserved Stn1-Ten1 complex.",
"Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.",
"The CST complex and telomere maintenance: the exception becomes the rule."
] | [
2007,
2007,
2009,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
880
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Family | CST complex subunit Ten1, fungal | CST complex subunit Ten1, fungal | Ten1_fungal | 4 |
IPR024224 | 24,224 | DENND6 | DENND6 | Family | 5,410 | false | false | The DENND6 family of proteins includes DENND6A and B. They act as guanine nucleotide exchange factors (GEF) for RAB14 [ ]. | [
"GO:0005085"
] | [
"guanyl-nucleotide exchange factor activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR13677"
] | [
""
] | [
5410
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-8876198",
"R-HSA-8876198",
"R-MMU-8876198"
] | [
"REACTOME:R-DDI-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198"
] | 3 | [] | 0 | [
"PUB00066797"
] | [
"22595670"
] | [
"Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardioides oceani"
] | [
5409,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
2,
6,
2,
6,
3,
3,
12,
9
] | 9 | true | Family | DENND6 | DENND6 | DENND6 | 5 |
IPR024225 | 24,225 | Cyclic-AMP phosphodiesterase class-II, conserved site | cAMP-PdiesteraseII_CS | Conserved_site | 701 | false | false | Cyclic-AMP phosphodiesterase ( ) (PDE) catalyses the hydrolysis of cAMP to the corresponding nucleoside 5' monophosphate. On the basis of sequence similarity, most PDEs can be grouped together [ ], but some enzymes lie apart from the main family and represent a second distinct class [ ] that includes PDEs from Dictyost... | [
"GO:0008081"
] | [
"phosphoric diester hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00607"
] | [
"PDEASE_II"
] | [
701
] | 1 | [
"EC"
] | [
"3.1.4.17"
] | [
"EC:3.1.4.17"
] | 1 | [
"4ojv",
"4ojx"
] | 2 | [
"PUB00003649",
"PUB00005554"
] | [
"2824992",
"2159198"
] | [
"Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.",
"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors."
] | [
1987,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
572,
128,
1
] | 3 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Conserved_site | Cyclic-AMP phosphodiesterase class-II, conserved site | Cyclic-AMP phosphodiesterase class-II, conserved site | cAMP-PdiesteraseII_CS | 9 |
IPR024227 | 24,227 | Domain of unknown function DUF3795 | DUF3795 | Domain | 1,724 | false | false | This domain is found in uncharacterised proteins from bacteria and archaea. These proteins are typically between 99 and 171 amino acids in length. These proteins are likely to be zinc-binding given the conserved cysteines. This domain can be found covering the total length of the protein or at the N- or C- terminal reg... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12675"
] | [
"DUF3795"
] | [
1724
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
169,
1419,
136
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3795 | Domain of unknown function DUF3795 | DUF3795 | 1 |
IPR024228 | 24,228 | Regulatory protein NPR, central domain | NPR_central_dom | Domain | 2,526 | false | false | This domain can be found in the plant NPR proteins. Arabidopsis NPR1 is a key regulator of the salicylic acid (SA)-mediated systemic acquired resistance (SAR) pathway [ ]. Its paralogs, NPR3, and NPR4, bind SA and control the proteasome-mediated degradation of NPR1 through their interaction with NPR1 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11900"
] | [
"DUF3420"
] | [
2526
] | 1 | [] | [] | [] | 0 | [
"7mk2",
"7mk3",
"7tac",
"7tad"
] | 4 | [
"PUB00075443",
"PUB00075444"
] | [
"25690466",
"25914712"
] | [
"NITRIC OXIDE-ASSOCIATED PROTEIN1 (AtNOA1) is essential for salicylic acid-induced root waving in Arabidopsis thaliana.",
"Integrating data on the Arabidopsis NPR1/NPR3/NPR4 salicylic acid receptors; a differentiating argument."
] | [
2015,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Tracheophyta"
] | [
2526
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
63,
10,
22
] | 3 | true | Domain | Regulatory protein NPR, central domain | Regulatory protein NPR, central domain | NPR_central_dom | 6 |
IPR024229 | 24,229 | Protein of unknown function DUF3781 | DUF3781 | Family | 561 | false | false | This family of functionally uncharacterised proteins is found in bacteria and archaea. These proteins are typically between 82 and 98 amino acids in length and have two conserved sequence motifs: GKNWY and ITA. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12636"
] | [
"DUF3781"
] | [
561
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"metagenomes"
] | [
532,
24,
5
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3781 | Protein of unknown function DUF3781 | DUF3781 | 6 |
IPR024230 | 24,230 | GspL, cytoplasmic actin-ATPase-like domain | GspL_cyto_dom | Domain | 4,642 | false | false | The general secretion pathway of Gram-negative bacteria is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05134"
] | [
"T2SSL"
] | [
4642
] | 1 | [] | [] | [] | 0 | [
"1w97",
"1yf5",
"2bh1",
"4pht",
"5tkw"
] | 5 | [
"PUB00010089",
"PUB00032212"
] | [
"10322014",
"15533433"
] | [
"Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae.",
"The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily."
] | [
1999,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4556,
7,
79
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | GspL, cytoplasmic actin-ATPase-like domain | GspL, cytoplasmic actin-ATPase-like domain | GspL_cyto_dom | 5 |
IPR024231 | 24,231 | Poly(A) polymerase, nucleotidyltransferase domain, Poxvirus | PolyA_pol_nucTrfase_Poxvir | Domain | 151 | false | false | Poly(A) polymerase ( ) catalyses template-independent extension of the 3'-end of a DNA or RNA strand by one nucleotide at a time. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heterodimer of a catalytic and a regulatory subunit. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heter... | [
"GO:1990817"
] | [
"poly(A) RNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03296"
] | [
"Pox_polyA_pol"
] | [
151
] | 1 | [
"EC"
] | [
"2.7.7.19"
] | [
"EC:2.7.7.19"
] | 1 | [
"2ga9",
"2gaf",
"3er8",
"3er9",
"3erc",
"3owg"
] | 6 | [
"PUB00040980"
] | [
"16678106"
] | [
"Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
151
] | 1 | [] | [] | 0 | true | Domain | Poly(A) polymerase, nucleotidyltransferase domain, Poxvirus | Poly(A) polymerase, nucleotidyltransferase domain, Poxvirus | PolyA_pol_nucTrfase_Poxvir | 2 |
IPR024232 | 24,232 | Stage III sporulation protein AH-like | SpoIIIAH | Family | 2,726 | false | false | Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12685"
] | [
"SpoIIIAH"
] | [
2726
] | 1 | [] | [] | [] | 0 | [
"3tuf",
"3uz0"
] | 2 | [
"PUB00088252"
] | [
"18485064"
] | [
"A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2698,
2,
26
] | 3 | [] | [] | 0 | true | Family | Stage III sporulation protein AH-like | Stage III sporulation protein AH-like | SpoIIIAH | 9 |
IPR024234 | 24,234 | Protein of unknown function DUF3801 | DUF3801 | Family | 3,037 | false | false | This functionally uncharacterised protein family is found in bacteria. Proteins found in this family are typically between 158 and 187 amino acids in length and include the PcfB protein. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12687"
] | [
"DUF3801"
] | [
3037
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Siphoviridae sp. ctoWO12",
"unclassified sequences"
] | [
2984,
1,
52
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3801 | Protein of unknown function DUF3801 | DUF3801 | 4 |
IPR024236 | 24,236 | Serine/threonine-protein kinase 40 | Ser/Thr_kinase_40 | Family | 1,006 | false | false | This entry represents serine/threonine-protein kinase 40 (STK40), also known as SINK-homologous inhibitory kinase (SHIK), which acts as a negative regulator of NF-kappa-B and p53-mediated gene transcription [ ]. It It was identified as a protein related to SINK, a p65-interacting protein that inhibits p65 phosphorylati... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd13974"
] | [
"STKc_SHIK"
] | [
1006
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [
"5l2q"
] | 1 | [
"PUB00055966"
] | [
"13679039"
] | [
"Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription."
] | [
2003
] | 1 | [
"IPR024104"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1006
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
3
] | 4 | true | Family | Serine/threonine-protein kinase 40 | Serine/threonine-protein kinase 40 | Ser/Thr_kinase_40 | 9 |
IPR024237 | 24,237 | VirE1 | VirE1 | Family | 39 | false | false | The VirE1 family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length and contain a conserved IELE sequence motif. VirE1 is an acidic chaperone protein which binds to VirE2, a ssDNA binding protein [ ]. These proteins are virulence factors of the plant pathogen Agrobacter... | [
"GO:0005515",
"GO:0006457"
] | [
"protein binding",
"protein folding"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"PFAM"
] | [
"NF010441",
"PF12189"
] | [
"PRK13867.1",
"VirE1"
] | [
32,
39
] | 2 | [] | [] | [] | 0 | [
"3btp"
] | 1 | [
"PUB00050766",
"PUB00104927",
"PUB00104928",
"PUB00104929"
] | [
"18678909",
"10542192",
"16262795",
"3547330"
] | [
"Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.",
"The Agrobacterium tumefaciens chaperone-like protein, VirE1, interacts with VirE2 at domains required for single-stranded DNA binding and cooperative interaction.",
"The V... | [
2008,
1999,
2005,
1987
] | 4 | [] | [] | 0 | 0 | null | [
"Rhizobium/Agrobacterium group"
] | [
39
] | 1 | [] | [] | 0 | true | Family | VirE1 | VirE1 | VirE1 | 8 |
IPR024238 | 24,238 | Initiator binding protein 39kDa, C-terminal | IBP39_C | Domain | 43 | false | false | This entry represents the C-terminal domain in IBP39 proteins. Initiator binding protein 39kDa (IBP39) recognises the initiator (Inr), which in Trichomonas vaginalis is solely responsible for transcription start site selection. IBP39 consists of an N-terminal Inr binding domain, a flexible linker, and a C-terminal doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11422"
] | [
"IBP39"
] | [
43
] | 1 | [] | [] | [] | 0 | [
"1q87",
"1q88",
"1q89"
] | 3 | [
"PUB00029945"
] | [
"14622596"
] | [
"Structural basis of core promoter recognition in a primitive eukaryote."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Acinetobacter",
"Parabasalia"
] | [
2,
41
] | 2 | [] | [] | 0 | true | Domain | Initiator binding protein 39kDa, C-terminal | Initiator binding protein 39kDa, C-terminal | IBP39_C | 5 |
IPR024239 | 24,239 | Exopolysaccharide production repressor | SyrA | Family | 533 | false | false | SyrA is a small protein located in the cytoplasmic membrane that lacks an apparent DNA binding domain. SyrA mediates the transcriptional up-regulation of exo genes involved in the biosynthesis of the symbiotic exopolysaccharide succinoglycan. It does this through a mechanism which requires a two component system [ ]. T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11089"
] | [
"SyrA"
] | [
533
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055969"
] | [
"17209018"
] | [
"Sinorhizobium meliloti SyrA mediates the transcriptional regulation of genes involved in lipopolysaccharide sulfation and exopolysaccharide biosynthesis."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Hyphomicrobiales"
] | [
533
] | 1 | [] | [] | 0 | true | Family | Exopolysaccharide production repressor | Exopolysaccharide production repressor | SyrA | 5 |
IPR024242 | 24,242 | Non-classical export protein 1 | NCE101 | Family | 988 | false | false | This entry represents the non classical export protein 1 family. Family members are Involved in a novel pathway of export of proteins that lack a cleavable signal sequence [ ]. | [
"GO:0009306"
] | [
"protein secretion"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF11654",
"PTHR28011"
] | [
"NCE101",
""
] | [
988,
302
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045337"
] | [
"8655575"
] | [
"A new pathway for protein export in Saccharomyces cerevisiae."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
988
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Non-classical export protein 1 | Non-classical export protein 1 | NCE101 | 7 |
IPR024244 | 24,244 | Protein of unknown function DUF2537 | DUF2537 | Family | 884 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10801"
] | [
"DUF2537"
] | [
884
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
881,
2,
1
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2537 | Protein of unknown function DUF2537 | DUF2537 | 6 |
IPR024245 | 24,245 | Cell wall synthesis protein CwsA | CwsA | Family | 349 | false | false | Cell wall synthesis protein CwsA is required for cell division, cell wall synthesis and cell shape maintenance [ ]. | [] | [] | [] | 0 | [
"HAMAP",
"PFAM"
] | [
"MF_00927",
"PF10814"
] | [
"CwsA",
"CwsA"
] | [
328,
349
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00064841"
] | [
"23002219"
] | [
"Mycobacterium tuberculosis CwsA interacts with CrgA and Wag31, and the CrgA-CwsA complex is involved in peptidoglycan synthesis and cell shape determination."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
349
] | 1 | [] | [] | 0 | true | Family | Cell wall synthesis protein CwsA | Cell wall synthesis protein CwsA | CwsA | 1 |
IPR024246 | 24,246 | Protein of unknown function DUF2674 | DUF2674 | Family | 45 | false | false | This family of proteins with unknown function appears to be restricted to Rickettsia spp. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10879"
] | [
"DUF2674"
] | [
45
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rickettsiales"
] | [
45
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2674 | Protein of unknown function DUF2674 | DUF2674 | 9 |
IPR024247 | 24,247 | Protein of unknown function DUF2673 | DUF2673 | Family | 44 | false | false | This family of proteins with unknown function appears to be restricted to Rickettsiae spp. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10880"
] | [
"DUF2673"
] | [
44
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria"
] | [
44
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2673 | Protein of unknown function DUF2673 | DUF2673 | 3 |
IPR024248 | 24,248 | Protein of unknown function DUF2695 | DUF2695 | Family | 497 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10905"
] | [
"DUF2695"
] | [
497
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Promethearchaeum syntrophicum",
"metagenomes"
] | [
481,
1,
15
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2695 | Protein of unknown function DUF2695 | DUF2695 | 1 |
IPR024249 | 24,249 | Protein of unknown function DUF2761 | DUF2761 | Family | 80 | false | false | Members of this family of proteins are annotated as KleF [ , ]. Their function is known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10959"
] | [
"DUF2761"
] | [
80
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055971",
"PUB00055972"
] | [
"7773415",
"8349548"
] | [
"Evolution of the korA-oriV segment of promiscuous IncP plasmids.",
"kil-kor regulon of promiscuous plasmid RK2: structure, products, and regulation of two operons that constitute the kilE locus."
] | [
1995,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"plasmids"
] | [
71,
9
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2761 | Protein of unknown function DUF2761 | DUF2761 | 6 |
IPR024250 | 24,250 | Protein of unknown function DUF2711 | DUF2711 | Family | 307 | false | false | Some members in this family of proteins are annotated as ywbB. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10924"
] | [
"DUF2711"
] | [
307
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
307
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2711 | Protein of unknown function DUF2711 | DUF2711 | 1 |
IPR024251 | 24,251 | Membrane protein, Torovirus | M_Torovirus | Family | 139 | false | false | This is a family of potential membrane proteins that may be components of the viral envelope. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10943"
] | [
"DUF2632"
] | [
139
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Torovirus"
] | [
139
] | 1 | [] | [] | 0 | true | Family | Membrane protein, Torovirus | Membrane protein, Torovirus | M_Torovirus | 1 |
IPR024252 | 24,252 | Protein of unknown function DUF2528 | DUF2528 | Family | 298 | false | false | Some sequences in this family are annotated as ea10. However the function of this protein family is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10800"
] | [
"DUF2528"
] | [
298
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Neoptera",
"Viruses",
"metagenomes"
] | [
232,
2,
62,
2
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF2528 | Protein of unknown function DUF2528 | DUF2528 | 4 |
IPR024253 | 24,253 | Phosducin, thioredoxin-like domain | Phosducin_thioredoxin-like_dom | Domain | 11,571 | false | false | The outer and inner segments of vertebrate rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A [ ]. The prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02114"
] | [
"Phosducin"
] | [
11571
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6814122",
"R-DME-6814122",
"R-HSA-6814122",
"R-MMU-6814122",
"R-RNO-6814122"
] | [
"REACTOME:R-BTA-6814122",
"REACTOME:R-DME-6814122",
"REACTOME:R-HSA-6814122",
"REACTOME:R-MMU-6814122",
"REACTOME:R-RNO-6814122"
] | 5 | [
"1a0r",
"1b9x",
"1b9y",
"2dbc",
"2trc",
"3evi",
"7nvm",
"8i1u",
"8i6j",
"8i9q",
"8i9u",
"8ib8",
"8sff",
"8sg8",
"8sgc",
"8sh9",
"8sha",
"8shf",
"8shg",
"8shl",
"8sho",
"8shp",
"8shq",
"8sht"
] | 24 | [
"PUB00001790",
"PUB00002577",
"PUB00051809"
] | [
"2210381",
"2203790",
"19193988"
] | [
"Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.",
"Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells.",
"Structure of the thioredoxin-fold domain of human phosducin-like protein 2."
] | [
1990,
1990,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11571
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
6,
3,
11,
10,
2,
2,
19,
1,
1,
10
] | 12 | true | Domain | Phosducin, thioredoxin-like domain | Phosducin, thioredoxin-like domain | Phosducin_thioredoxin-like_dom | 2 |
IPR024254 | 24,254 | MJ0366-like | MJ0366-like | Family | 52 | false | false | This family of proteins, previously known as DUF2540, includes Uncharacterized protein MJ0366 from Methanocaldococcus jannaschii and similar proteins predominantly found in Methanococci. This protein adopts the 3-1 trefoil knot conformation [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10802"
] | [
"DUF2540"
] | [
52
] | 1 | [] | [] | [] | 0 | [
"2efv"
] | 1 | [
"PUB00100668"
] | [
"27845039"
] | [
"Crystal structure analysis of a hypothetical protein (MJ0366) from Methanocaldococcus jannaschii revealed a novel topological arrangement of the knot fold."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Methanocaldococcus fervens tailed virus 1",
"Methanococcales"
] | [
1,
51
] | 2 | [] | [] | 0 | true | Family | MJ0366-like | MJ0366-like | MJ0366-like | 6 |
IPR024255 | 24,255 | Spore germination GerPB | GerPB | Family | 892 | false | false | Members of this family are required for formation of functionally normal spores. They may be involved in the establishment of spore coat structure or permeability [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10803"
] | [
"GerPB"
] | [
892
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044278"
] | [
"10715007"
] | [
"Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
892
] | 1 | [] | [] | 0 | true | Family | Spore germination GerPB | Spore germination GerPB | GerPB | 3 |
IPR024256 | 24,256 | Domain of unknown function DUF3797 | DUF3797 | Domain | 106 | false | false | This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12677"
] | [
"DUF3797"
] | [
106
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Caudoviricetes"
] | [
94,
12
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3797 | Domain of unknown function DUF3797 | DUF3797 | 4 |
IPR024258 | 24,258 | Protein of unknown function DUF3798 | DUF3798 | Family | 537 | false | false | This entry represents functionally uncharacterised proteins that are found in bacteria. They are typically between 247 and 417 amino acids in length. Most of the proteins in this entry have an N-terminal lipoprotein attachment site. These proteins have distant similarity to periplasmic ligand binding families suggestin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12683"
] | [
"DUF3798"
] | [
537
] | 1 | [] | [] | [] | 0 | [
"3qi7"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aduncisulcus paluster",
"Bacteria",
"ecological metagenomes"
] | [
1,
525,
11
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3798 | Protein of unknown function DUF3798 | DUF3798 | 8 |
IPR024259 | 24,259 | Alkylmercury lyase, helix-turn-helix domain | MerB_HTH_dom | Domain | 522 | false | false | Alkylmercury lyase ( ) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. This entry represents the N-terminal helix-turn-helix domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12324"
] | [
"HTH_15"
] | [
522
] | 1 | [
"EC"
] | [
"4.99.1.2"
] | [
"EC:4.99.1.2"
] | 1 | [
"1s6l",
"3f0o",
"3f0p",
"3f2f",
"3f2g",
"3f2h",
"3fn8",
"5c0t",
"5c0u",
"5dsf",
"5u79",
"5u7a",
"5u7b",
"5u7c",
"5u82",
"5u83",
"5u88"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
512,
7,
3
] | 3 | [] | [] | 0 | true | Domain | Alkylmercury lyase, helix-turn-helix domain | Alkylmercury lyase, helix-turn-helix domain | MerB_HTH_dom | 3 |
IPR024260 | 24,260 | Vacuolar segregation subunit 7 | Vac7 | Family | 1,418 | false | false | Vac7 is localised at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance [ ]. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway [ ]. The Fab1 lipid pathway is important for correct regulation of membrane trafficking even... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12751",
"PTHR28258"
] | [
"Vac7",
""
] | [
1406,
1387
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055974",
"PUB00055975",
"PUB00100166"
] | [
"9372916",
"11950935",
"34347309"
] | [
"Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology.",
"Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.",
"TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be li... | [
1997,
2002,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1418
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Family | Vacuolar segregation subunit 7 | Vacuolar segregation subunit 7 | Vac7 | 5 |
IPR024261 | 24,261 | RNA binding protein She2 | RNA-bd_She2 | Domain | 68 | false | false | This entry represents the main structural domain of She2. She2 is a RNA binding protein which binds to RNA via a helical hairpin. The protein is required for the actin dependent transport of ASH1 mRNA in yeast, a form of mRNP translocation [ ]. She2 contains a globular domain consisting of a bundle of five α-helices [ ... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11435"
] | [
"She2p"
] | [
68
] | 1 | [] | [] | [] | 0 | [
"1xly",
"4wnl",
"5m0i",
"5m0j"
] | 4 | [
"PUB00032457"
] | [
"15537539"
] | [
"She2p is a novel RNA binding protein with a basic helical hairpin motif."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
68
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | RNA binding protein She2 | RNA binding protein She2 | RNA-bd_She2 | 3 |
IPR024264 | 24,264 | Domain of unknown function DUF3786 | DUF3786 | Domain | 1,211 | false | false | This presumed domain is functionally uncharacterised and is found in bacteria. Proteins containing this domain are typically between 201 and 257 amino acids in length. Some proteins also contains an iron-sulphur cluster. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12654"
] | [
"DUF3786"
] | [
1211
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudovirales sp. ctqPn17",
"unclassified sequences"
] | [
37,
1096,
1,
77
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3786 | Domain of unknown function DUF3786 | DUF3786 | 5 |
IPR024265 | 24,265 | Protein of unknown function DUF3788 | DUF3788 | Family | 1,113 | false | false | This family of functionally uncharacterised proteins is found in bacteria and archaea. Proteins in this family are typically between 137 and 149 amino acids in length and may be distantly related to RelE proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12663"
] | [
"DUF3788"
] | [
1113
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati",
"Plasmid NR79",
"metagenomes"
] | [
1055,
12,
1,
45
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3788 | Protein of unknown function DUF3788 | DUF3788 | 8 |
IPR024267 | 24,267 | Domain of unknown function DUF4878 | DUF4878 | Domain | 506 | false | false | This is a domain found in a group of sequences from bacteria. Proteins containing this domain are probably related to the NTF2-like transpeptidase family. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12870"
] | [
"DUF4878"
] | [
506
] | 1 | [] | [] | [] | 0 | [
"3k7c"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
495,
11
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF4878 | Domain of unknown function DUF4878 | DUF4878 | 4 |
IPR024268 | 24,268 | rRNA methyltransferase AviRa | AviRa | Family | 220 | false | false | This family of proteins includes the methyltransferase AviRa from Streptomyces viridochromogenes. This protein mediates the resistance to the antibiotic avilamycin. AviRa methylates a specific guanine base within the peptidyl-transferase loop of the 23S ribosomal RNA [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11599"
] | [
"AviRa"
] | [
220
] | 1 | [] | [] | [] | 0 | [
"1o9g",
"1o9h"
] | 2 | [
"PUB00029356"
] | [
"12742024"
] | [
"Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
217,
2,
1
] | 3 | [] | [] | 0 | true | Family | rRNA methyltransferase AviRa | rRNA methyltransferase AviRa | AviRa | 9 |
IPR024269 | 24,269 | Protein of unknown function DUF3791 | DUF3791 | Family | 1,189 | false | false | This entry represents proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12668"
] | [
"DUF3791"
] | [
1189
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomethylophilus alvi",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
1160,
2,
3,
24
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3791 | Protein of unknown function DUF3791 | DUF3791 | 5 |
IPR024270 | 24,270 | Urocortin II/III | Urocortin_II/III | Family | 847 | false | false | This entry represents urocortin II and III, which are members of the corticotropin-releasing factor (CRF) family of neuropeptides. Urocortin II and III are secreted peptides and bind with high affinity to CRF receptors 2-alpha and 2-beta. They are involved in the suppression of food intake, the delay of gastric emptyin... | [
"GO:0051431",
"GO:0007586",
"GO:0005615"
] | [
"corticotropin-releasing hormone receptor 2 binding",
"digestion",
"extracellular space"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR17575"
] | [
""
] | [
847
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-373080",
"R-HSA-373080",
"R-MMU-373080",
"R-RNO-373080"
] | [
"REACTOME:R-BTA-373080",
"REACTOME:R-HSA-373080",
"REACTOME:R-MMU-373080",
"REACTOME:R-RNO-373080"
] | 4 | [
"2rmg",
"2rmh"
] | 2 | [
"PUB00049427"
] | [
"18052377"
] | [
"Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
847
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
6
] | 4 | true | Family | Urocortin II/III | Urocortin II/III | Urocortin_II/III | 2 |
IPR024271 | 24,271 | Protein of unknown function DUF3782 | DUF3782 | Family | 1,001 | false | false | This functionally uncharacterised family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12644"
] | [
"DUF3782"
] | [
1001
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
250,
748,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3782 | Protein of unknown function DUF3782 | DUF3782 | 6 |
IPR024272 | 24,272 | MAFF2-related | MAFF-rel | Family | 1,836 | false | false | This family of short membrane proteins are related to the protein Maff2. Maff2 lies just outside the direct repeats of a tetracycline resistance transposable element. This protein family may contain transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12750"
] | [
"Maff2"
] | [
1836
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Siphoviridae sp. ctoWO12",
"unclassified sequences"
] | [
1808,
1,
27
] | 3 | [] | [] | 0 | true | Family | MAFF2-related | MAFF2-related | MAFF-rel | 2 |
IPR024274 | 24,274 | Anaphase-promoting complex, subunit 9 | APC9 | Family | 104 | false | false | The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, there... | [
"GO:0005680"
] | [
"anaphase-promoting complex"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF12856"
] | [
"ANAPC9"
] | [
104
] | 1 | [] | [] | [] | 0 | [
"8a3t",
"8a5y",
"8a61"
] | 3 | [
"PUB00055977",
"PUB00055978",
"PUB00059221"
] | [
"16896351",
"20037474",
"18485873"
] | [
"The anaphase promoting complex/cyclosome: a machine designed to destroy.",
"APC-targeted RAA1 degradation mediates the cell cycle and root development in plants.",
"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
] | [
2006,
2010,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
104
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Anaphase-promoting complex, subunit 9 | Anaphase-promoting complex, subunit 9 | APC9 | 8 |
IPR024276 | 24,276 | Crustacean cardioactive peptide | CCAP | Family | 358 | false | false | Crustacean cardioactive peptide (CCAP), also known as cardioacceleratory peptide 2a, exerts a reversible and dose-dependent cardio-stimulatory effect on the semi-isolated heart of experimental beetles. CCAP also increases free hemolymph sugar concentration in young larvae and adults of the meal-worm beetle [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11105"
] | [
"CCAP"
] | [
358
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055979"
] | [
"18521612"
] | [
"Pleiotropic effects of the neuropeptides CCAP and myosuppressin in the beetle, Tenebrio molitor L."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
358
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Crustacean cardioactive peptide | Crustacean cardioactive peptide | CCAP | 1 |
IPR024277 | 24,277 | Domain of unknown function DUF3821 | DUF3821 | Domain | 137 | false | false | This is a domain largely confined to sequences from Methanomicrobiales. It is found in putative lipases but the function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12863"
] | [
"DUF3821"
] | [
137
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanomicrobiales",
"hydrocarbon metagenome"
] | [
133,
4
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3821 | Domain of unknown function DUF3821 | DUF3821 | 6 |
IPR024279 | 24,279 | Paramyxovirinae protein V, zinc-binding domain | Paramyx_V_Zn-bd | Domain | 464 | false | false | The paramyxoviruses, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [ ]. The P mRNA encodes a ... | [
"GO:0046872"
] | [
"metal ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF13008"
] | [
"zf-Paramyx-P"
] | [
464
] | 1 | [] | [] | [] | 0 | [
"2b5l",
"2hye",
"4i1s",
"9ujo"
] | 4 | [
"PUB00039527",
"PUB00045065",
"PUB00055980"
] | [
"16413485",
"14645906",
"15140960"
] | [
"Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.",
"Structural disorder and modular organization in Paramyxovirinae N and P.",
"Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic ... | [
2006,
2003,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Paramyxoviridae"
] | [
464
] | 1 | [] | [] | 0 | true | Domain | Paramyxovirinae protein V, zinc-binding domain | Paramyxovirinae protein V, zinc-binding domain | Paramyx_V_Zn-bd | 3 |
IPR024280 | 24,280 | FAM167 | FAM167 | Family | 1,720 | false | false | This entry describes a eukaryotic protein family of unknown function designated FAM167. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11652"
] | [
"FAM167"
] | [
1720
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1720
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
4,
4,
5
] | 4 | true | Family | FAM167 | FAM167 | FAM167 | 4 |
IPR024281 | 24,281 | Bacteriophage T7-like virion assembly protein | Phage_T7-like_viron_assmbl | Family | 449 | false | false | This family of proteins represents the gene product 7.3 from T7 bacteriophage and T7-like phages. The protein is localised to the tail and is thought to be important in virion assembly. Particles assembled in the absence of the protein fail to adsorb to cells [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11653"
] | [
"VirionAssem_T7"
] | [
449
] | 1 | [] | [] | [] | 0 | [
"9jyz"
] | 1 | [
"PUB00055981"
] | [
"16054667"
] | [
"Changes in bacteriophage T7 virion structure at the initiation of infection."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
8,
441
] | 2 | [] | [] | 0 | true | Family | Bacteriophage T7-like virion assembly protein | Bacteriophage T7-like virion assembly protein | Phage_T7-like_viron_assmbl | 9 |
IPR024283 | 24,283 | Translocase of chloroplast 159/132, membrane anchor domain | TOC159_MAD | Domain | 2,664 | false | false | This is the membrane-anchor domain of translocase of chloroplast 159, TOC159/132. This domain is present in plants at the C terminus of the GTPase, AIG1, and anchors the GTPase region to the outer membrane of the chloroplast. The domain may carry a very C-terminal sequence motif that resembles a transit peptide [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11886"
] | [
"TOC159_MAD"
] | [
2664
] | 1 | [
"EC"
] | [
"3.6.5.-"
] | [
"EC:3.6.5.-"
] | 1 | [] | 0 | [
"PUB00075666"
] | [
"24966864"
] | [
"Targeting and assembly of components of the TOC protein import complex at the chloroplast outer envelope membrane."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
2664
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
19,
30
] | 3 | true | Domain | Translocase of chloroplast 159/132, membrane anchor domain | Translocase of chloroplast 159/132, membrane anchor domain | TOC159_MAD | 8 |
IPR024284 | 24,284 | Protein of unknown function DUF3826 | DUF3826 | Family | 688 | false | false | This is a putative sugar-binding family. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12875"
] | [
"DUF3826"
] | [
688
] | 1 | [] | [] | [] | 0 | [
"3g6i",
"3kdw",
"6goc"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Tanacetum cinerariifolium",
"metagenomes"
] | [
677,
2,
9
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3826 | Protein of unknown function DUF3826 | DUF3826 | 3 |
IPR024285 | 24,285 | Schizont-infected cell agglutination, extracellular beta domain | SICA_extracell_b | Domain | 614 | false | false | The schizont-infected cell agglutination (SICA) proteins of Plasmodium knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. SICA proteins comprise multiple domains, with the extracellular cysteine-rich domains (CRDs) occurring at different frequencies. They contain a five-cystein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12878"
] | [
"SICA_beta"
] | [
614
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055982"
] | [
"18843368"
] | [
"The genome of the simian and human malaria parasite Plasmodium knowlesi."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
614
] | 1 | [] | [] | 0 | true | Domain | Schizont-infected cell agglutination, extracellular beta domain | Schizont-infected cell agglutination, extracellular beta domain | SICA_extracell_b | 1 |
IPR024286 | 24,286 | Domain of unknown function DUF3700 | DUF3700 | Domain | 3,978 | false | false | This entry represents a domain found in plant proteins that is approximately 120 amino acids in length. There are two conserved sequence motifs: YGL and LRDR. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF12481",
"SM01172"
] | [
"DUF3700",
"DUF3700"
] | [
3746,
3741
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
211,
3767
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
22,
21,
28
] | 3 | true | Domain | Domain of unknown function DUF3700 | Domain of unknown function DUF3700 | DUF3700 | 4 |
IPR024289 | 24,289 | Domain of unknown function DUF3828 | DUF3828 | Domain | 2,896 | false | false | This entry represents a domain found covering the whole length of Putative periplasmic protein Rpic12D_3261 from Ralstonia pickettii ( , Tai3), a cognate immunity protein from the type VI secretion system (T6SS) that shows four helices and five strands [ ]. This domain is also found in uncharacterised bacterial protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12883"
] | [
"DUF3828"
] | [
2896
] | 1 | [] | [] | [] | 0 | [
"4hz9",
"4hzb",
"9v52",
"9v53",
"9v55"
] | 5 | [
"PUB00101006"
] | [
"23730712"
] | [
"Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
2889,
3,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Domain of unknown function DUF3828 | Domain of unknown function DUF3828 | DUF3828 | 2 |
IPR024290 | 24,290 | Schizont-infected cell agglutination, extracellular alpha domain | SICA_extracell_a | Domain | 705 | false | false | The schizont-infected cell agglutination (SICA) proteins of Plasmodium knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. SICA proteins comprise multiple domains, with the extracellular cysteine-rich domains (CRDs) occurring at different frequencies. They contain a five-cystein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12887"
] | [
"SICA_alpha"
] | [
705
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055982"
] | [
"18843368"
] | [
"The genome of the simian and human malaria parasite Plasmodium knowlesi."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
705
] | 1 | [] | [] | 0 | true | Domain | Schizont-infected cell agglutination, extracellular alpha domain | Schizont-infected cell agglutination, extracellular alpha domain | SICA_extracell_a | 8 |
IPR024291 | 24,291 | Protein of unknown function DUF3829 | DUF3829 | Family | 2,329 | false | false | This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL/GvpF family of gas vesicle synthesis proteins ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12889"
] | [
"DUF3829"
] | [
2329
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"human gut metagenome"
] | [
2324,
3,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF3829 | Protein of unknown function DUF3829 | DUF3829 | 1 |
IPR024292 | 24,292 | Nodavirus capsid | Nodavirus_capsid | Family | 867 | false | false | The capsid or coat protein of this family is expressed in Nodaviridae, that are ssRNA positive-strand viruses, with no DNA stage. These viruses are the causative agents of viral nervous necrosis in marine fish [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11729"
] | [
"Capsid-VNN"
] | [
867
] | 1 | [] | [] | [] | 0 | [
"3jbm",
"4nwv",
"4nww",
"4rft",
"4rfu",
"4wiz",
"6rj0",
"8xid",
"8yf6",
"8yf7",
"8yf8",
"8yf9"
] | 12 | [
"PUB00055983"
] | [
"9049363"
] | [
"Comparison of the coat protein genes of five fish nodaviruses, the causative agents of viral nervous necrosis in marine fish."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Viruses"
] | [
5,
862
] | 2 | [] | [] | 0 | true | Family | Nodavirus capsid | Nodavirus capsid | Nodavirus_capsid | 9 |
IPR024294 | 24,294 | Protein of unknown function DUF3810 | DUF3810 | Family | 2,564 | false | false | This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 333 and 377 amino acids in length and contain a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterised family of peptidase e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12725"
] | [
"DUF3810"
] | [
2564
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Daphnia sinensis",
"metagenomes"
] | [
2520,
1,
43
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3810 | Protein of unknown function DUF3810 | DUF3810 | 5 |
IPR024295 | 24,295 | Protein of unknown function DUF2705 | DUF2705 | Family | 7,682 | false | false | This bacterial family of proteins has no known function. This family includes uncharacterised proteins YybM and YybK from B.subtilis which are both classified in TCDB in the atp-binding cassette (abc) superfamily 3.A.1.158.1. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10920"
] | [
"DUF2705"
] | [
7682
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rhizophagus irregularis",
"unclassified sequences"
] | [
7,
7542,
2,
131
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF2705 | Protein of unknown function DUF2705 | DUF2705 | 1 |
IPR024296 | 24,296 | Protein of unknown function DUF2710 | DUF2710 | Family | 223 | false | false | This family of uncharacterised proteins appears to be restricted to Mycobacteriaceae. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10921"
] | [
"DUF2710"
] | [
223
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
223
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2710 | Protein of unknown function DUF2710 | DUF2710 | 4 |
IPR024297 | 24,297 | Inorganic phosphate transporter chaperone Pho86 | Pho86 | Family | 165 | false | false | Pho86p is an ER chaperone required for chaperoning multi-pass membrane proteins through the ER membrane compartment [ , ]. It is essential for growth when phosphate levels are limiting [ ], being involved in the regulation of Pho84p, a high-affinity phosphate transporter, which is localised to the endoplasmic reticulum... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11124"
] | [
"Pho86"
] | [
165
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017155",
"PUB00055984"
] | [
"15623581",
"10655492"
] | [
"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.",
"Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p."
] | [
2005,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
165
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Inorganic phosphate transporter chaperone Pho86 | Inorganic phosphate transporter chaperone Pho86 | Pho86 | 5 |
IPR024298 | 24,298 | Sec16, Sec23-binding domain | Sec16_Sec23-bd | Domain | 12,905 | false | false | COPII coat assembly protein sec16 (Sec16) is a multi-domain vesicle coat protein that binds to COPII-coated vesicles, regulating the transport of secretory proteins from the endoplasmic reticulum. This entry represents the C-terminal domain of Sec16 from eukaryotes and related sequences such as Protein transport protei... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12931"
] | [
"TPR_Sec16"
] | [
12905
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-204005",
"R-DDI-204005",
"R-HSA-204005",
"R-HSA-2132295",
"R-HSA-381038",
"R-HSA-9725370",
"R-HSA-983170",
"R-MMU-204005",
"R-MMU-2132295",
"R-MMU-983170",
"R-RNO-204005",
"R-RNO-2132295",
"R-RNO-983170",
"R-SCE-204005",
"R-SPO-204005"
] | [
"REACTOME:R-CEL-204005",
"REACTOME:R-DDI-204005",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-381038",
"REACTOME:R-HSA-9725370",
"REACTOME:R-HSA-983170",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU-2132295",
"REACTOME:R-MMU-983170",
"REACTOME:R-RNO-204005",
"REACTOME:R-RNO-... | 15 | [
"2pm6",
"2pm7",
"3mzk",
"3mzl",
"4bzj",
"4bzk",
"6zg5",
"6zg6",
"6zl0"
] | 9 | [
"PUB00051815",
"PUB00055324",
"PUB00055985",
"PUB00155876",
"PUB00155877",
"PUB00155878"
] | [
"18974315",
"20696705",
"7593161",
"27492621",
"25619252",
"33511128"
] | [
"Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.",
"Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat.",
"Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.",
"Sec16 alternative splicing dyna... | [
2008,
2010,
1995,
2016,
2015,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Eukaryota"
] | [
9,
12896
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
7,
14,
11,
22,
7,
2,
11,
19,
2,
2,
150
] | 12 | true | Domain | Sec16, Sec23-binding domain | Sec16, Sec23-binding domain | Sec16_Sec23-bd | 8 |
IPR024299 | 24,299 | NigD-like N-terminal OB domain | NigD-like_OB_dom | Domain | 829 | false | false | This entry represents the N-terminal OB domain found in a group of proteins from bacteroidetes, including NigD1 (BT_4005) from Bacteroides thetaiotaomicron and the predicted mannosylglucose phosphorylase BF0700 from Bacteroides fragilis ( ) [ ]. NigD1 is a protein encoded adjacent to genes required for biosynthesis and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12667"
] | [
"NigD_N"
] | [
829
] | 1 | [] | [] | [] | 0 | [
"3k0y",
"3k6o",
"3qwn",
"4j8q",
"4pqx"
] | 5 | [
"PUB00159008",
"PUB00159009"
] | [
"38422018",
"35328479"
] | [
"Dual membrane-spanning anti-sigma factors regulate vesiculation in <i>Bacteroides thetaiotaomicron</i>.",
"Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases."
] | [
2024,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
799,
1,
29
] | 3 | [] | [] | 0 | true | Domain | NigD-like N-terminal OB domain | NigD-like N-terminal OB domain | NigD-like_OB_dom | 9 |
IPR024301 | 24,301 | Putative amidase domain | Amidase_6 | Domain | 4,171 | false | false | This entry represents a putative amidase domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12671"
] | [
"Amidase_6"
] | [
4171
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aciduliprofundum boonei (strain DSM 19572 / T469)",
"Bacteria",
"Eukaryota",
"Fernvirus",
"metagenomes"
] | [
1,
4115,
29,
6,
20
] | 5 | [] | [] | 0 | true | Domain | Putative amidase domain | Putative amidase domain | Amidase_6 | 8 |
IPR024302 | 24,302 | SusD-like | SusD-like | Family | 3,360 | false | false | Mammalian distal gut bacteria have an expanded capacity to utilise glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an indiv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12741"
] | [
"SusD-like"
] | [
3360
] | 1 | [] | [] | [] | 0 | [
"3cgh",
"3ehm",
"3ehn",
"3gzs",
"3sgh",
"4f53",
"4f7a",
"4mru",
"4puc",
"5j90",
"6dmf",
"6e60",
"6e61",
"7nox",
"7o8c",
"8j0p",
"8jxz",
"8uwv"
] | 18 | [
"PUB00051695"
] | [
"19191477"
] | [
"Structure of a SusD homologue, BT1043, involved in mucin O-glycan utilization in a prominent human gut symbiont."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Siphoviridae sp. ctBLh2",
"metagenomes"
] | [
3299,
3,
1,
57
] | 4 | [] | [] | 0 | true | Family | SusD-like | SusD-like | SusD-like | 3 |
IPR024303 | 24,303 | Natural killer cell receptor 2B4, immunoglobulin domain | NK_rcpt_2B4_Ig_dom | Domain | 837 | false | false | 2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells [ ]. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two β-s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11465"
] | [
"Receptor_2B4"
] | [
837
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-MMU-202733",
"R-RNO-202733"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-MMU-202733",
"REACTOME:R-RNO-202733"
] | 3 | [
"1z2k",
"2ptt",
"2ptu"
] | 3 | [
"PUB00038719"
] | [
"15850375"
] | [
"NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
837
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
8,
7
] | 4 | true | Domain | Natural killer cell receptor 2B4, immunoglobulin domain | Natural killer cell receptor 2B4, immunoglobulin domain | NK_rcpt_2B4_Ig_dom | 7 |
IPR024307 | 24,307 | Spore germination protein GerY | GerY | Family | 1,117 | false | false | This entry represents spore germination protein GerY and related proteins. GerY is a spore protein that enables efficient transit of nutrients across the spore coat to trigger germination [ ]. It is required for efficient spore germination in response to both L-alanine and a mixture of L-asparagine, D-glucose, D-fructo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12788"
] | [
"YmaF"
] | [
1117
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00163275"
] | [
"39530705"
] | [
"Identification and characterization of the <i>Bacillus subtilis</i> spore germination protein GerY."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati",
"bioreactor metagenome"
] | [
1114,
3
] | 2 | [] | [] | 0 | true | Family | Spore germination protein GerY | Spore germination protein GerY | GerY | 8 |
IPR024309 | 24,309 | Nuclear Testis protein, N-terminal | NUT_N | Domain | 900 | false | false | This domain is found in the N-terminal region of Nuclear Testis (NUT) proteins. The NUT gene is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma, due to chromosomal translocations [ , ]. The BRD family proteins contain two bromodomains that bind transcriptionally active chromatin through associat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12881"
] | [
"NUT"
] | [
900
] | 1 | [] | [] | [] | 0 | [
"7xez"
] | 1 | [
"PUB00021074",
"PUB00055988",
"PUB00055989",
"PUB00055990"
] | [
"9323133",
"12543779",
"17934517",
"9311922"
] | [
"CRM1 is an export receptor for leucine-rich nuclear export signals.",
"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.",
"BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.",
"Evidence for a... | [
1997,
2003,
2008,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
900
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
2,
5
] | 3 | true | Domain | Nuclear Testis protein, N-terminal | Nuclear Testis protein, N-terminal | NUT_N | 5 |
IPR024310 | 24,310 | NUT family | NUT | Family | 888 | false | false | The gene encoding Nuclear Testis (NUT) protein is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma due to chromosomal translocations [ , ]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [ , ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22879"
] | [
""
] | [
888
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00021074",
"PUB00055988",
"PUB00055989",
"PUB00055990"
] | [
"9323133",
"12543779",
"17934517",
"9311922"
] | [
"CRM1 is an export receptor for leucine-rich nuclear export signals.",
"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.",
"BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.",
"Evidence for a... | [
1997,
2003,
2008,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
888
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
2,
5
] | 3 | true | Family | NUT family | NUT family | NUT | 3 |
IPR024311 | 24,311 | Lipocalin-like domain | Lipocalin-like | Domain | 8,893 | false | false | The lipocalin fold is dominated by eight β-strands which together form a cup-shaped antiparallel β-barrel that encloses an internal ligand-binding site [ ]. This entry represents domains with a fold that is related to the to the lipocalin fold. | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PFAM",
"PFAM"
] | [
"PF12702",
"PF13648",
"PF13924",
"PF13944",
"PF16585"
] | [
"Lipocalin_3",
"Lipocalin_4",
"Lipocalin_5",
"Calycin_like",
"Lipocalin_8"
] | [
466,
4387,
3130,
582,
328
] | 5 | [] | [] | [] | 0 | [
"2mhd",
"3hty",
"3rwx",
"5byp"
] | 4 | [
"PUB00005013"
] | [
"7684291"
] | [
"Structure and sequence relationships in the lipocalins and related proteins."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"unclassified Caudoviricetes"
] | [
7998,
821,
70,
4
] | 4 | [] | [] | 0 | true | Domain | Lipocalin-like domain | Lipocalin-like domain | Lipocalin-like | 3 |
IPR024312 | 24,312 | TACC, C-terminal, fungi | TACC_C_fungi | Domain | 1,169 | false | false | This entry represents a conserved region predicted as coiled-coil and located toward the C terminus of TACC proteins. TACC proteins are present in different organisms, ranging from yeasts to mammals. Schizosaccharomyces pombe has one TACC protein, known as Alp7 or Mia1p [ ]. Alp7/TACC consists of two domains: the N-ter... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12709"
] | [
"Fungal_TACC"
] | [
1169
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045149",
"PUB00086636",
"PUB00086638",
"PUB00086639",
"PUB00086640",
"PUB00086641"
] | [
"14742702",
"18656360",
"11432827",
"24937146",
"10427094",
"12354097"
] | [
"Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.",
"The TACC proteins: TACC-ling microtubule dynamics and centrosome function.",
"Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is ... | [
2004,
2008,
2001,
2014,
1999,
2002
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1169
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | TACC, C-terminal, fungi | TACC, C-terminal, fungi | TACC_C_fungi | 2 |
IPR024314 | 24,314 | Suppressor of fused C-terminal | SUFU_C | Domain | 1,891 | false | false | This entry represents the C-terminal domain of eukaryotic suppressor of fused (Sufu) proteins. It folds into a domain that comprises a four-stranded and a six-stranded β-sheet, both with mixed topologies, which are connected by two antiparallel α-helices [ , ]. Sufu is a repressor of the Gli and Ci transcription factor... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12470"
] | [
"SUFU_C"
] | [
1891
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610780",
"R-HSA-5610783",
"R-HSA-5610785",
"R-HSA-5610787",
"R-HSA-5632684",
"R-MMU-5610780",
"R-MMU-5610785",
"R-MMU-5610787",
"R-MMU-5632684"
] | [
"REACTOME:R-HSA-5610780",
"REACTOME:R-HSA-5610783",
"REACTOME:R-HSA-5610785",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5632684",
"REACTOME:R-MMU-5610780",
"REACTOME:R-MMU-5610785",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5632684"
] | 9 | [
"4bl8",
"4bl9",
"4bla",
"4blb",
"4bld",
"4km8",
"4km9",
"4kma",
"4kmd",
"4kmh"
] | 10 | [
"PUB00028921",
"PUB00097449",
"PUB00097450",
"PUB00101143"
] | [
"15367681",
"24217340",
"24311597",
"28965847"
] | [
"Suppressor of fused regulates Gli activity through a dual binding mechanism.",
"Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.",
"Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.",
"Hypomorphic Recessive Variants in SUFU ... | [
2004,
2013,
2013,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1891
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
3,
4,
4
] | 5 | true | Domain | Suppressor of fused C-terminal | Suppressor of fused C-terminal | SUFU_C | 3 |
IPR024315 | 24,315 | Domain of unknown function DUF3805 | DUF3805 | Domain | 259 | false | false | This entry represents an N-terminal domain found in a family of bacterial proteins, whose function is unknown. In two related Bacteroides species, the gene for members of this family lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structur... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12712"
] | [
"DUF3805"
] | [
259
] | 1 | [] | [] | [] | 0 | [
"3hlz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
254,
5
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3805 | Domain of unknown function DUF3805 | DUF3805 | 8 |
IPR024316 | 24,316 | Nuclear pore assembly and biogenesis protein, APQ12 | APQ12 | Family | 984 | false | false | This is a family of conserved fungal proteins involved in nuclear pore assembly [ ]. APQ12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Its absence leads to a partial block in mRNA export and cold-sensitive defects in the growth and localisation of a subset of nucleoporins, pa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12716"
] | [
"Apq12"
] | [
984
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055992",
"PUB00055993",
"PUB00055994"
] | [
"15273328",
"17724120",
"20016074"
] | [
"The yeast Apq12 protein affects nucleocytoplasmic mRNA transport.",
"The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes.",
"Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmi... | [
2004,
2007,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
984
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Nuclear pore assembly and biogenesis protein, APQ12 | Nuclear pore assembly and biogenesis protein, APQ12 | APQ12 | 9 |
IPR024318 | 24,318 | Negative regulator of Ofd1/Enhancer of translation termination 1 | Nro1/ETT1 | Family | 375 | false | false | In fission yeast, Nro1 is a positive regulator of the stability of Sre1N, the sterol regulatory element-binding protein, which is an ER membrane-bound transcription factor that controls adaptation to low oxygen-growth [ ]. In addition, the fission yeast Nro1 is a direct inhibitor of a protein that inhibits SreN1 degrad... | [
"GO:0005515",
"GO:0005634"
] | [
"protein binding",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF12753",
"PTHR28290"
] | [
"Nro1",
""
] | [
295,
371
] | 2 | [] | [] | [] | 0 | [
"3msv",
"3qtm",
"3qtn"
] | 3 | [
"PUB00045331",
"PUB00055996",
"PUB00056187",
"PUB00056188",
"PUB00056189"
] | [
"19158663",
"10684247",
"21610214",
"14671320",
"20630870"
] | [
"Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.",
"The yeast nuclear pore complex: composition, architecture, and transport mechanism.",
"Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in ... | [
2009,
2000,
2011,
2003,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
375
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Negative regulator of Ofd1/Enhancer of translation termination 1 | Negative regulator of Ofd1/Enhancer of translation termination 1 | Nro1/ETT1 | 6 |
IPR024319 | 24,319 | ATPase expression protein 2, mitochondrial | ATPase_expression_mit | Family | 982 | false | false | ATPase expression protein 2 (also known as ATP13 in some species) is necessary for the expression of subunit 9 of mitochondrial ATPase. The protein has a basic amino terminal signal sequence that is cleaved upon import into mitochondria [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12921"
] | [
"ATP13"
] | [
982
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056006"
] | [
"1825065"
] | [
"ATP13, a nuclear gene of Saccharomyces cerevisiae essential for the expression of subunit 9 of the mitochondrial ATPase."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
982
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | ATPase expression protein 2, mitochondrial | ATPase expression protein 2, mitochondrial | ATPase_expression_mit | 4 |
IPR024320 | 24,320 | Phosphatidylglycerol lysyltransferase, C-terminal | LPG_synthase_C | Domain | 16,013 | false | false | This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyses the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG) [ ]. This is the hydrophilic domain which includes the active ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09924"
] | [
"LPG_synthase_C"
] | [
16013
] | 1 | [
"EC",
"EC"
] | [
"2.3.2.3",
"6.1.1.6"
] | [
"EC:2.3.2.3",
"EC:6.1.1.6"
] | 2 | [
"2hqy",
"4v34",
"4v35",
"4v36",
"5vrv",
"6lv0",
"6lvf",
"7duw",
"7f47",
"9goe",
"9j8q",
"9j8r",
"9j8s"
] | 13 | [
"PUB00056129",
"PUB00078731",
"PUB00101369"
] | [
"14769468",
"19649276",
"35365094"
] | [
"MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.",
"The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.",
"LysX2 is a M... | [
2004,
2009,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
140,
14010,
1705,
158
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Domain | Phosphatidylglycerol lysyltransferase, C-terminal | Phosphatidylglycerol lysyltransferase, C-terminal | LPG_synthase_C | 4 |
IPR024321 | 24,321 | Protease inhibitor, falstatin | Prot_Inh_falstatin | Family | 66 | false | false | This family of peptidase inhibitors is expressed in plasmodial protozoal species. Falstatin is found to be a potent reversible inhibitor of the P. falciparum cysteine proteases falcipain-2 and falcipain-3, as well as other parasite- and non-parasite-derived cysteine proteases, but is only a relatively weak inhibitor of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12628"
] | [
"Inhibitor_I71"
] | [
66
] | 1 | [] | [] | [] | 0 | [
"3pnr"
] | 1 | [
"PUB00055997",
"PUB00152831",
"PUB00152832"
] | [
"17083274",
"20361051",
"24281719"
] | [
"Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion.",
"Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.",
"Inhibitor of cysteine proteases is critic... | [
2006,
2010,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Candidatus Nitrosarchaeum limnium BG20",
"Plasmodium"
] | [
1,
65
] | 2 | [] | [] | 0 | true | Family | Protease inhibitor, falstatin | Protease inhibitor, falstatin | Prot_Inh_falstatin | 3 |
IPR024322 | 24,322 | Protein of unknown function DUF2682 | DUF2682 | Family | 19 | false | false | The function of these viral proteins is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10909"
] | [
"DUF2682"
] | [
19
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphabaculovirus"
] | [
19
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2682 | Protein of unknown function DUF2682 | DUF2682 | 7 |
IPR024324 | 24,324 | Condensin complex subunit 1, N-terminal | Condensin_cplx_su1_N | Domain | 4,173 | false | false | Condensin is a multi-subunit protein complex that acts as an essential regulator of chromosome condensation [ , ]. It contains both SMC (structural maintenance of chromosomes) and non-SMC subunits. Condensin plays an important role during mitosis in the compaction and resolution of chromosomes to remove and prevent cat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12922"
] | [
"Cnd1_N"
] | [
4173
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2514853",
"R-MMU-2514853",
"R-SCE-2514853",
"R-SPO-2514853"
] | [
"REACTOME:R-HSA-2514853",
"REACTOME:R-MMU-2514853",
"REACTOME:R-SCE-2514853",
"REACTOME:R-SPO-2514853"
] | 4 | [
"6qj3",
"6qj4",
"6yvu",
"6yvv",
"7q2x",
"7q2y",
"7qen"
] | 7 | [
"PUB00010072",
"PUB00010073",
"PUB00056005",
"PUB00100765"
] | [
"9774278",
"10485849",
"20442714",
"27737959"
] | [
"Phosphorylation and activation of 13S condensin by Cdc2 in vitro.",
"Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.",
"Condensin and cohesin complexity: the expanding repertoire of functions.",
"Mutations in genes encoding condensi... | [
1998,
1999,
2010,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4173
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
8,
1,
1,
7,
3,
1,
3,
4,
1,
1,
11
] | 11 | true | Domain | Condensin complex subunit 1, N-terminal | Condensin complex subunit 1, N-terminal | Condensin_cplx_su1_N | 9 |
IPR024325 | 24,325 | Domain of unknown function DUF3835 | DUF3835 | Domain | 1,496 | false | false | This domain is found in a number of fungal proteins whose function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12927"
] | [
"DUF3835"
] | [
1496
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dictyobacter vulcani",
"Eukaryota"
] | [
1,
1495
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Domain of unknown function DUF3835 | Domain of unknown function DUF3835 | DUF3835 | 3 |
IPR024326 | 24,326 | Ribosomal RNA-processing protein 7, C-terminal domain | RRP7_C | Domain | 4,363 | false | false | Ribosomal RNA-processing protein 7 (RRP7) is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [ ]. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [ , ]. This entry represents the C-terminal domain of RRP7. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12923"
] | [
"RRP7"
] | [
4363
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 6 | [
"2mby",
"4m5d",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"9n6v"... | 42 | [
"PUB00056007",
"PUB00056190"
] | [
"9271380",
"17515605"
] | [
"Functional analysis of Rrp7p, an essential yeast protein involved in pre-rRNA processing and ribosome assembly.",
"The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism."
] | [
1997,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4363
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
1,
2,
4,
1,
2,
3,
1,
1,
7
] | 12 | true | Domain | Ribosomal RNA-processing protein 7, C-terminal domain | Ribosomal RNA-processing protein 7, C-terminal domain | RRP7_C | 7 |
IPR024328 | 24,328 | Protein of unknown function DUF3845 | DUF3845 | Family | 60 | false | false | This entry represents a family of uncharacterised bacterial proteins. One member, , shows significant structural similarity to TNF-like jelly roll fold, which may indicate an immunomodulatory function [ ] or a bioadhesion role [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12956"
] | [
"DUF3845"
] | [
60
] | 1 | [] | [] | [] | 0 | [
"3gf6"
] | 1 | [
"PUB00055998",
"PUB00055999"
] | [
"20346680",
"20152153"
] | [
"The molecular regulation of programmed necrotic cell injury.",
"A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens."
] | [
2010,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteroidaceae"
] | [
60
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3845 | Protein of unknown function DUF3845 | DUF3845 | 2 |
IPR024329 | 24,329 | Amyloidogenic glycoprotein, E2 domain | Amyloid_glyco_E2_domain | Domain | 6,964 | false | false | Amyloid-beta precursor protein (APP, or A4) is associated with Alzheimer's disease (AD), because one of its breakdown products, amyloid-beta (A-beta), aggregates to form amyloid or senile plaques [ , , ]. Mutations in APP or in proteins that process APP have been linked with early-onset, familial AD. Individuals with D... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF12925",
"PS51870"
] | [
"APP_E2",
"APP_E2"
] | [
6941,
6912
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-114608",
"R-CEL-3000178",
"R-CEL-381426",
"R-CEL-416476",
"R-CEL-8957275",
"R-CEL-9609523",
"R-DME-114608",
"R-DME-3000178",
"R-DME-381426",
"R-DME-416476",
"R-DME-8957275",
"R-DME-9609523",
"R-DME-9837999",
"R-HSA-114608",
"R-HSA-3000178",
"R-HSA-381426",
"R-HSA-416476",
"R... | [
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-3000178",
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-416476",
"REACTOME:R-CEL-8957275",
"REACTOME:R-CEL-9609523",
"REACTOME:R-DME-114608",
"REACTOME:R-DME-3000178",
"REACTOME:R-DME-381426",
"REACTOME:R-DME-416476",
"REACTOME:R-DME-8957275",
"REACTOME:R-DM... | 67 | [
"1tkn",
"3k66",
"3k6b",
"3nyj",
"3nyl",
"3pmr",
"3q7g",
"3q7l",
"3qmk",
"3umh",
"3umi",
"3umk",
"4rd9",
"4rda",
"4yn0",
"5buo",
"5tpt",
"8kew",
"8kf1",
"8kf3",
"8kf4",
"8kf5",
"8kf6",
"8otf"
] | 24 | [
"PUB00029624",
"PUB00030814",
"PUB00031484",
"PUB00033916",
"PUB00033917",
"PUB00033918",
"PUB00099232",
"PUB00099233"
] | [
"12611883",
"15304215",
"15274612",
"16301322",
"16406235",
"16364896",
"28713158",
"33302541"
] | [
"Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.",
"The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.",
"Three-dimensional structure of an independently folded extracellular domain of h... | [
2003,
2004,
2004,
2006,
2006,
2005,
2017,
2020
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
6962,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
16,
6,
26,
23,
16
] | 6 | true | Domain | Amyloidogenic glycoprotein, E2 domain | Amyloidogenic glycoprotein, E2 domain | Amyloid_glyco_E2_domain | 9 |
IPR024330 | 24,330 | Protein of unknown function DUF3852 | DUF3852 | Family | 248 | false | false | This entry represents a family of uncharacterised bacterial proteins found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12963"
] | [
"DUF3852"
] | [
248
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"metagenomes"
] | [
230,
18
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3852 | Protein of unknown function DUF3852 | DUF3852 | 2 |
IPR024331 | 24,331 | Domain of unknown function DUF3859 | DUF3859 | Domain | 879 | false | false | This entry represents a functionally uncharacterised domain, which is found in bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12975"
] | [
"DUF3859"
] | [
879
] | 1 | [] | [] | [] | 0 | [
"3n6y"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
868,
11
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3859 | Domain of unknown function DUF3859 | DUF3859 | 6 |
IPR024332 | 24,332 | MOZART2 family | MOZART2 | Family | 1,121 | false | false | The MOZART2 family of proteins (also known as FAM128 and Mitotic-spindle organizing protein 2) operate as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it co... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12926",
"PTHR28578"
] | [
"MOZART2",
""
] | [
1095,
1004
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-380270",
"R-BTA-380320",
"R-HSA-380270",
"R-HSA-380320",
"R-MMU-380270",
"R-MMU-380320",
"R-XTR-380270",
"R-XTR-380320"
] | [
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380320",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380320",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380320",
"REACTOME:R-XTR-380270",
"REACTOME:R-XTR-380320"
] | 8 | [
"6x0v",
"7fad",
"8rx1",
"9g3y",
"9g3z",
"9g40",
"9h9p",
"9qvm"
] | 8 | [
"PUB00056001"
] | [
"20360068"
] | [
"Systematic analysis of human protein complexes identifies chromosome segregation proteins."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1121
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
8,
2,
3
] | 4 | true | Family | MOZART2 family | MOZART2 family | MOZART2 | 7 |
IPR024334 | 24,334 | Domain of unknown function DUF3863 | DUF3863 | Domain | 153 | false | false | This entry represents a functionally uncharacterised domain found in bacterial sequences. The structure of one of the sequences, from Parabacteroides distasonis atcc 8503, has been determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12979"
] | [
"DUF3863"
] | [
153
] | 1 | [] | [] | [] | 0 | [
"3lm3"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
150,
3
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3863 | Domain of unknown function DUF3863 | DUF3863 | 5 |
IPR024335 | 24,335 | Domain of unknown function DUF3864 | DUF3864 | Domain | 119 | false | false | This entry represents a functionally uncharacterised domain found in bacterial sequences. The structure of one of the sequences, from Parabacteroides distasonis atcc 8503, has been determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12980"
] | [
"DUF3864"
] | [
119
] | 1 | [] | [] | [] | 0 | [
"3lm3"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
117,
2
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3864 | Domain of unknown function DUF3864 | DUF3864 | 1 |
IPR024336 | 24,336 | tRNA-splicing endonuclease, subunit Sen54, N-terminal | tRNA_splic_suSen54_N | Domain | 4,216 | false | false | tRNA-splicing endonucleases ( ) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [ , ]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12928"
] | [
"tRNA_int_end_N2"
] | [
4216
] | 1 | [
"REACTOME"
] | [
"R-HSA-6784531"
] | [
"REACTOME:R-HSA-6784531"
] | 1 | [
"7uxa",
"7zrz",
"8hmy",
"8hmz",
"8iss"
] | 5 | [
"PUB00054270",
"PUB00055529",
"PUB00056002"
] | [
"9321408",
"9200603",
"18711368"
] | [
"RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history.",
"The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.",
"tRNA splicing endonuclease mutations cause pont... | [
1997,
1997,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardioides malaquae"
] | [
4215,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
23,
2,
10,
1,
1,
2,
5,
1,
1,
6
] | 12 | true | Domain | tRNA-splicing endonuclease, subunit Sen54, N-terminal | tRNA-splicing endonuclease, subunit Sen54, N-terminal | tRNA_splic_suSen54_N | 3 |
IPR024337 | 24,337 | tRNA-splicing endonuclease, subunit Sen54 | tRNA_splic_suSen54 | Family | 4,541 | false | false | tRNA-splicing endonucleases ( ) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [ , ]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21027"
] | [
""
] | [
4541
] | 1 | [
"REACTOME"
] | [
"R-HSA-6784531"
] | [
"REACTOME:R-HSA-6784531"
] | 1 | [
"7uxa",
"7zrz",
"8hmy",
"8hmz",
"8iss"
] | 5 | [
"PUB00054270",
"PUB00055529",
"PUB00056002"
] | [
"9321408",
"9200603",
"18711368"
] | [
"RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history.",
"The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.",
"tRNA splicing endonuclease mutations cause pont... | [
1997,
1997,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardioides malaquae"
] | [
4540,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
23,
2,
10,
5,
1,
2,
5,
1,
1,
8
] | 12 | true | Family | tRNA-splicing endonuclease, subunit Sen54 | tRNA-splicing endonuclease, subunit Sen54 | tRNA_splic_suSen54 | 1 |
IPR024338 | 24,338 | Stretch-activated cation channel MID1/Yam8 | MID1/Yam8 | Family | 1,806 | false | false | In Saccharomyces cerevisiae, Mid1 is a yeast plasma membrane protein required for Ca2+ influx induced by the mating pheromone alpha-factor during the mating process [ , , ]. The protein is composed of 548-amino-acid residues, contains four hydrophobic regions (H1, H2, H3 and H4) and two cysteine-rich regions (C1 and C2... | [
"GO:0005262",
"GO:0098703"
] | [
"calcium channel activity",
"calcium ion import across plasma membrane"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF12929",
"PTHR39142"
] | [
"Mid1",
""
] | [
1805,
1594
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056158",
"PUB00056159",
"PUB00056160",
"PUB00086861"
] | [
"16202999",
"11796727",
"14697255",
"11016847"
] | [
"Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca2+ permeation.",
"Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.",
"Phe356 in ... | [
2005,
2002,
2004,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1806
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Stretch-activated cation channel MID1/Yam8 | Stretch-activated cation channel MID1/Yam8 | MID1/Yam8 | 3 |
IPR024339 | 24,339 | Protein of unknown function DUF3836 | DUF3836 | Family | 634 | false | false | This entry represents a family of bacterial proteins of unknown function. These proteins fold into a single-layer anti-parallel β-sheet, comprised of three or four twisted β-hairpin repeats. Small clusters of hydrophobic residues adjacent to the turns are likely to play a significant role in the structural stability of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12930"
] | [
"DUF3836"
] | [
634
] | 1 | [] | [] | [] | 0 | [
"3msw",
"4r03",
"4r8o"
] | 3 | [
"PUB00103944"
] | [
"31306512"
] | [
"Structures of single-layer β-sheet proteins evolved from β-hairpin repeats."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Siphoviridae sp. ctEgn5",
"unclassified sequences"
] | [
625,
1,
8
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3836 | Protein of unknown function DUF3836 | DUF3836 | 6 |
IPR024340 | 24,340 | Sec16, central conserved domain | Sec16_CCD | Domain | 5,752 | false | false | The yeast protein Sec16 plays a key role in the formation of coat protein II vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus [ ]. Mammals have two isoforms of this protein - Sec16A and Sec16B. Sec16A appears to be the primary orthologue as it has the highest sequence... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12932"
] | [
"Sec16"
] | [
5752
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-204005",
"R-HSA-204005",
"R-MMU-204005",
"R-RNO-204005",
"R-SCE-204005",
"R-SPO-204005"
] | [
"REACTOME:R-CEL-204005",
"REACTOME:R-HSA-204005",
"REACTOME:R-MMU-204005",
"REACTOME:R-RNO-204005",
"REACTOME:R-SCE-204005",
"REACTOME:R-SPO-204005"
] | 6 | [
"3mzk"
] | 1 | [
"PUB00055985",
"PUB00056003",
"PUB00056004"
] | [
"7593161",
"21768384",
"19638414"
] | [
"Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.",
"Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.",
"Organisation of human ER-exit sites: requirements for the localisation of Sec... | [
1995,
2011,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5752
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
14,
7,
6,
10,
4,
1,
6,
7,
1,
1,
51
] | 11 | true | Domain | Sec16, central conserved domain | Sec16, central conserved domain | Sec16_CCD | 2 |
IPR024341 | 24,341 | Protein of unknown function DUF2631 | DUF2631 | Family | 1,409 | false | false | This entry represents a family of proteins from Actinobacteria, including MSMEG_2575 from Mycolicibacterium smegmatis ( ) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10939"
] | [
"DUF2631"
] | [
1409
] | 1 | [] | [] | [] | 0 | [
"6adq",
"7e1v",
"7e1w",
"7e1x",
"7q21",
"7qhm",
"7qho",
"7rh5",
"7rh6",
"7rh7",
"8ovc",
"8ovd",
"9dm1",
"9ftz",
"9fu0",
"9gy6"
] | 16 | [
"PUB00098865"
] | [
"30361386"
] | [
"An electron transfer path connects subunits of a mycobacterial respiratory supercomplex."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"freshwater metagenome"
] | [
1407,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2631 | Protein of unknown function DUF2631 | DUF2631 | 5 |
IPR024343 | 24,343 | Capsid protein VP4, dicistrovirus | VP4_dicistrovir | Domain | 275 | false | false | This domain represents VP4, a minor capsid protein from dicistroviridae which is processed from the capsid polyprotein. The dicistroviridae is a group of small, RNA-containing viruses that are closely structurally related to the picornaviridae. VP4 is a short, extended polypeptide chain found within the viral capsid, a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11492"
] | [
"Dicistro_VP4"
] | [
275
] | 1 | [] | [] | [] | 0 | [
"1b35",
"5lwg",
"6iic",
"6shl",
"7bc3",
"7bg8",
"7bgk"
] | 7 | [
"PUB00035375"
] | [
"10426956"
] | [
"The crystal structure of cricket paralysis virus: the first view of a new virus family."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Endopterygota",
"Kosakonia oryziphila",
"Viruses",
"viral metagenome"
] | [
4,
1,
269,
1
] | 4 | [] | [] | 0 | true | Domain | Capsid protein VP4, dicistrovirus | Capsid protein VP4, dicistrovirus | VP4_dicistrovir | 5 |
IPR024344 | 24,344 | Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain | MDMPI_metal-binding | Domain | 36,819 | false | false | This entry represents the N-terminal metal-binding domain in mycothiol-dependent maleylpyruvate isomerases [ ]. | [
"GO:0046872"
] | [
"metal ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11716"
] | [
"MDMPI_N"
] | [
36819
] | 1 | [] | [] | [] | 0 | [
"2nsf",
"2nsg"
] | 2 | [
"PUB00042028"
] | [
"17428791"
] | [
"Crystal structures and site-directed mutagenesis of a mycothiol-dependent enzyme reveal a novel folding and molecular basis for mycothiol-mediated maleylpyruvate isomerization."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
36431,
12,
376
] | 3 | [] | [] | 0 | true | Domain | Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain | Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain | MDMPI_metal-binding | 9 |
IPR024345 | 24,345 | DNA maturase, bacteriophage T7-like | DNA_matur_Phage_T7-like | Family | 1,131 | false | false | This entry represents Gp18 (gene 18 product, also known as DNA maturase A and Terminase, small subunit gp18) from T7-like bacteriophages. In Bacteriophage T3, this protein is required for DNA packaging and functions in a complex with Gp19 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11123"
] | [
"DNA_Packaging_2"
] | [
1131
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056009"
] | [
"6240154"
] | [
"Purification and properties of gene 18 product of bacteriophage T3."
] | [
1984
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
85,
2,
1041,
3
] | 4 | [] | [] | 0 | true | Family | DNA maturase, bacteriophage T7-like | DNA maturase, bacteriophage T7-like | DNA_matur_Phage_T7-like | 7 |
IPR024346 | 24,346 | Tegument protein, herpes virus, N-terminal domain | Tegument_herpes_virus_N | Domain | 383 | false | false | This entry represents the N-terminal domain of tegument proteins from double-stranded DNA herpesvirus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12818"
] | [
"Tegument_dsDNA"
] | [
383
] | 1 | [] | [] | [] | 0 | [
"5kdm"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Orthoherpesviridae"
] | [
383
] | 1 | [] | [] | 0 | true | Domain | Tegument protein, herpes virus, N-terminal domain | Tegument protein, herpes virus, N-terminal domain | Tegument_herpes_virus_N | 4 |
IPR024348 | 24,348 | Peptidase C62, gill-associated virus | Pept_C62_gill-assoc_virus | Family | 24 | false | false | This protease is found in polyproteins from the positive-stranded RNA virus of prawns called yellow head virus or gill-associated virus (GAV). The GAV cysteine proteinase (3C-like proteinase) is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, polyprotein 1a and polyprotein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12380"
] | [
"Peptidase_C62"
] | [
24
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056175"
] | [
"12502857"
] | [
"The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Pisuviricota",
"Spirodela intermedia",
"Streptacidiphilus"
] | [
21,
1,
2
] | 3 | [] | [] | 0 | true | Family | Peptidase C62, gill-associated virus | Peptidase C62, gill-associated virus | Pept_C62_gill-assoc_virus | 3 |
IPR024349 | 24,349 | Human herpesvirus 5 RL5A/RL6 | HHV5_RL5A/RL6 | Family | 96 | false | false | This entry represents RL5A and RL6 from human herpesvirus 5. RL5A and RL6 are members of the RL11 family, which are predicted to encode membrane glycoproteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11088"
] | [
"RL11D"
] | [
96
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056010"
] | [
"12604818"
] | [
"Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Human cytomegalovirus"
] | [
96
] | 1 | [] | [] | 0 | true | Family | Human herpesvirus 5 RL5A/RL6 | Human herpesvirus 5 RL5A/RL6 | HHV5_RL5A/RL6 | 9 |
IPR024350 | 24,350 | Hepatitus C virus, Non-structural 5a protein, C-terminal | HCV_NS5a_C | Domain | 27,426 | false | false | Although Hepatitis A virus, Hepatitis B virus, and Hepatitis C virus have similar names, because they all cause liver inflammation, these are distinctly different viruses both genetically and clinically. The Hepatitis C virus (HCV) is a small (50-80 nm in diameter), enveloped, single-stranded, positive sense RNA virus.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12941"
] | [
"HCV_NS5a_C"
] | [
27426
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.21.98",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210",
"R-HSA-5621480",
"R-HSA-8854214"
] | [
"EC:2.7.7.48",
"EC:3.4.21.98",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214"
] | 12 | [
"4j1v"
] | 1 | [
"PUB00017179",
"PUB00017180",
"PUB00099826"
] | [
"9143277",
"9710605",
"25443344"
] | [
"Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.",
"Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.",
"Virology and cell biology of the hepat... | [
1997,
1998,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
27426
] | 1 | [] | [] | 0 | true | Domain | Hepatitus C virus, Non-structural 5a protein, C-terminal | Hepatitus C virus, Non-structural 5a protein, C-terminal | HCV_NS5a_C | 2 |
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