LiteFold/InterPro · Datasets at Hugging Face

IPR024468

24,468

Sec16, N-terminal

Sec16_N

Domain

526

false

Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. The yeast protein Sec16 plays a key role in the formation of coat protein II vesicles, which mediate protein transport from the endoplasmic reticulum...

[]

0

[ "PFAM" ]

[ "PF12935" ]

[ "Sec16_N" ]

[ 526 ]

1

[ "REACTOME" ]

[ "R-SCE-204005" ]

[ "REACTOME:R-SCE-204005" ]

1

[]

0

[ "PUB00055985" ]

[ "7593161" ]

[ "Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p." ]

[ 1995 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 526 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Sec16, N-terminal

Sec16_N

6

IPR024470

24,470

Protein of unknown function DUF2545

DUF2545

Family

506

false

This family of proteins with unknown function appear to be restricted to Enterobacteriaceae. Their sequences are highly conserved.

[]

0

[ "PFAM" ]

[ "PF10810" ]

[ "DUF2545" ]

[ 506 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 505, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2545

DUF2545

8

IPR024471

24,471

Protein of unknown function DUF2715

DUF2715

Family

212

false

This family of proteins with unknown function appears to be largely found in spirochaete bacteria. They are related to membrane β barrel proteins.

[]

0

[ "PFAM" ]

[ "PF10895" ]

[ "DUF2715" ]

[ 212 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 205, 7 ]

2

[]

0

true

Family

Protein of unknown function DUF2715

DUF2715

9

IPR024473

24,473

Transposase, IS4, N-terminal

Transposases_IS4_N

Domain

3,325

false

This entry represents the N-terminal domain of Insertion Element 4 transposases [ ].

[]

0

[ "PFAM" ]

[ "PF13006" ]

[ "Nterm_IS4" ]

[ 3325 ]

1

[]

0

[]

0

[ "PUB00056053" ]

[ "2996976" ]

[ "Joint distribution of insertion elements IS4 and IS5 in natural isolates of Escherichia coli." ]

[ 1985 ]

1

[]

0

null

[ "Bacteria", "Insertion sequence IS4", "Meripilus lineatus", "metagenomes" ]

[ 3299, 1, 1, 24 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Transposase, IS4, N-terminal

Transposases_IS4_N

5

IPR024474

24,474

Transposase IS66, zinc-finger binding domain of

Znf_dom_IS66

Domain

11,605

false

This is a zinc-finger region of the N terminus of the insertion element IS66 transposase [ ].

[]

0

[ "PFAM" ]

[ "PF13005" ]

[ "zf-IS66" ]

[ 11605 ]

1

[]

0

[]

0

[ "PUB00011506" ]

[ "11418571" ]

[ "Structural and functional characterization of IS679 and IS66-family elements." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes", "plasmids" ]

[ 11250, 34, 173, 9, 137, 2 ]

6

[]

0

true

Domain

Transposase IS66, zinc-finger binding domain of

Znf_dom_IS66

8

IPR024475

24,475

Type IV conjugative transfer protein TrbJ/K, C-terminal

TrbJ/K_C

Domain

717

false

This domain is found C-terminal in bacterial proteins encoded by the TrbJ and TrbK genes of the Ti plasmid conjugative transfer operon [ ].

[]

0

[ "PFAM" ]

[ "PF10907" ]

[ "DUF2749" ]

[ 717 ]

1

[]

0

[]

0

[ "PUB00019242" ]

[ "10438776" ]

[ "Essential components of the Ti plasmid trb system, a type IV macromolecular transporter." ]

[ 1999 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 717 ]

1

[]

0

true

Domain

Type IV conjugative transfer protein TrbJ/K, C-terminal

TrbJ/K_C

1

IPR024477

24,477

Protein of unknown function DUF3865, CADD-like

DUF3865_CADD-like

Family

67

false

This entry represents a family of proteins of unknown function. The Nostoc punctiforme protein ( ) has been structurally characterised and adopts a heme oxygenase-like fold similar to that of the Chlamydia trachomatis death domain-binding CADD protein. The proposed active sites of the Nostoc and Chlamydia sequences are...

[]

0

[ "PFAM" ]

[ "PF12981" ]

[ "DUF3865" ]

[ 67 ]

1

[]

0

[ "3b5o", "3b5p" ]

2

[]

0

[]

0

null

[ "Bacteria" ]

[ 67 ]

1

[]

0

true

Family

Protein of unknown function DUF3865, CADD-like

DUF3865_CADD-like

9

IPR024478

24,478

Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain

HlyB_4HB_MCP

Domain

37,671

false

This entry represents a four-helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction, which is known as four-helix bundles methyl-accepting chemotaxis protein (4HB_MCP) domain. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only ex...

[]

0

[ "PFAM" ]

[ "PF12729" ]

[ "4HB_MCP_1" ]

[ 37671 ]

1

[]

0

[ "5xua", "5xub", "6its", "7wrm", "8bsa", "8bsb", "9kup" ]

7

[ "PUB00056054", "PUB00085582" ]

[ "16306392", "8401237" ]

[ "Four-helix bundle: a ubiquitous sensory module in prokaryotic signal transduction.", "Vibrio cholerae hlyB is a member of the chemotaxis receptor gene family." ]

[ 2005, 1993 ]

2

[]

[ "IPR047347" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 67, 37366, 46, 2, 190 ]

5

[]

0

true

Domain

Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain

HlyB_4HB_MCP

2

IPR024479

24,479

Protein of unknown function DUF3866

DUF3866

Family

1,580

false

This family of proteins is currently functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF12982" ]

[ "DUF3866" ]

[ 1580 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1559, 21 ]

2

[]

0

true

Family

Protein of unknown function DUF3866

DUF3866

7

IPR024480

24,480

Domain of unknown function DUF3868

DUF3868

Domain

1,153

false

This domain of unknown function is found at the N-terminal end of a group of proteins from bacteroidetes. The function of the proteins is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].

[]

0

[ "PFAM" ]

[ "PF12984" ]

[ "DUF3868" ]

[ 1153 ]

1

[]

0

[]

0

[ "PUB00056011", "PUB00056012" ]

[ "15790854", "16735464" ]

[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Bacteroidales", "Viruses", "metagenomes" ]

[ 1140, 2, 11 ]

3

[]

0

true

Domain

Domain of unknown function DUF3868

DUF3868

7

IPR024481

24,481

Helicase Sen1, N-terminal

Helicase_Sen1_N

Domain

2,275

false

The yeast helicase Sen1 is an ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs [ , ] and it also has an ATPase-dependent ability of promoting transcription term...

[]

0

[ "PFAM" ]

[ "PF12726" ]

[ "SEN1_N" ]

[ 2275 ]

1

[]

0

[ "8fth", "8ftk", "8ram", "8ran", "8rao", "8rap" ]

6

[ "PUB00056056", "PUB00056154", "PUB00070285", "PUB00095913", "PUB00095917" ]

[ "1569945", "15121901", "8943355", "28408439", "32075754" ]

[ "SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae.", "Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing.", "Repression of gene expression by an exogenous se...

[ 1992, 2004, 1996, 2017, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2275 ]

1

[ "Danio rerio", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1, 1, 1, 2 ]

5

true

Domain

Helicase Sen1, N-terminal

Helicase_Sen1_N

7

IPR024482

24,482

Domain of unknown function DUF3855

DUF3855

Domain

5

false

This domain forms an unusual α/β fold where a six-stranded antiparallel β-sheet is wrapped around a central α-helix, flanked by an additional α-helix and a small sub-domain consisting of a single β-strand and a two-stranded antiparallel β-sheet [ ]. It shows weak structural similarities to phosphoribosylformylglycinami...

[]

0

[ "PFAM" ]

[ "PF12967" ]

[ "DUF3855" ]

[ 5 ]

1

[]

0

[ "1o22" ]

1

[ "PUB00029305" ]

[ "15229892" ]

[ "Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold." ]

[ 2004 ]

1

[]

0

null

[ "Thermotoga" ]

[ 5 ]

1

[]

0

true

Domain

Domain of unknown function DUF3855

DUF3855

4

IPR024483

24,483

Glia associated membrane protein glam-1

Glam1

Family

209

false

This entry represents Glia associated membrane protein glam-1 from Caenorhabditis elegans (Glam1) and similar worm proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10912", "PTHR35013" ]

[ "Glam1", "" ]

[ 203, 154 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 207 ]

2

[ "Caenorhabditis elegans" ]

[ 8 ]

1

true

Family

Glia associated membrane protein glam-1

Glam1

6

IPR024484

24,484

CT_538/TC_0825

CT_538-like

Family

46

false

Members of this family appear restricted to Chlamydiales. Their function is unknown. This entry includes Uncharacterized protein CT_538, Uncharacterized protein TC_0825 and Protein CPn_0658/CP_0089/CPj0658/CpB0684.

[]

0

[ "PFAM" ]

[ "PF10915" ]

[ "DUF2709" ]

[ 46 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 45, 1 ]

2

[]

0

true

Family

CT_538/TC_0825

CT_538-like

6

IPR024485

24,485

Protein of unknown function DUF2680

DUF2680

Family

592

false

Members in this family of proteins are annotated as YckD however currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10925" ]

[ "DUF2680" ]

[ 592 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Setaria digitata", "ecological metagenomes" ]

[ 578, 1, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF2680

DUF2680

7

IPR024486

24,486

Protein of unknown function DUF2617

DUF2617

Family

1,881

false

This is a family of proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF10936" ]

[ "DUF2617" ]

[ 1881 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Cladocopium goreaui", "Halobacteriales", "ecological metagenomes" ]

[ 1801, 1, 70, 9 ]

4

[]

0

true

Family

Protein of unknown function DUF2617

DUF2617

8

IPR024487

24,487

Cellulose biosynthesis protein BcsR-like

CBP_BcsR

Family

1,251

false

Cellulose is necessary for biofilm formation in bacteria and is synthesized by the bacterial cellulose biosynthesis complex (Bcs) which is widespread among beta and gamma proteobacteria [ , ]. CBP_BcsR is a small subunit of this complex, essential for cellulose secretion [ ]. It may play a regulatory role together with...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF040717", "PF10945" ]

[ "BcsR_only", "CBP_BcsR" ]

[ 916, 1233 ]

2

[]

0

[ "6yar", "6yay", "6yb3", "6yb5", "6ybb", "6ybu", "9fnn", "9fp0", "9fp2" ]

9

[ "PUB00075887", "PUB00086869", "PUB00105928", "PUB00151583" ]

[ "26077867", "24097954", "29234007", "33563593" ]

[ "Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions.", "Cellulose as an architectural element in spatially structured Escherichia coli biofilms.", "Insights into the structure and assembly of a bacterial cellulose secretion system.", "Architecture and regulation of an en...

[ 2015, 2013, 2017, 2021 ]

4

[]

0

null

[ "Pseudomonadota", "metagenomes" ]

[ 1240, 11 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cellulose biosynthesis protein BcsR-like

CBP_BcsR

9

IPR024488

24,488

Protein of unknown function DUF2777

DUF2777

Family

619

false

This family of proteins with unknown function appears to be restricted to Bacillaceae.

[]

0

[ "PFAM" ]

[ "PF10949" ]

[ "DUF2777" ]

[ 619 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli" ]

[ 619 ]

1

[]

0

true

Family

Protein of unknown function DUF2777

DUF2777

6

IPR024489

24,489

Organ specific protein

Organ_specific_prot

Family

1,343

false

This eukaryotic family includes a number of plant organ-specific proteins. While their function is unknown, their predicted amino acid sequence suggests that these proteins could be exported and glycosylated [ ].

[]

0

[ "PFAM" ]

[ "PF10950" ]

[ "Organ_specific" ]

[ 1343 ]

1

[]

0

[]

0

[ "PUB00056161" ]

[ "2102854" ]

[ "Differential expression of two related organ-specific genes in pea." ]

[ 1990 ]

1

[]

0

null

[ "Mesangiospermae" ]

[ 1343 ]

1

[ "Arabidopsis thaliana" ]

[ 2 ]

1

true

Family

Organ specific protein

Organ_specific_prot

6

IPR024490

24,490

Protein of unknown function DUF2759

DUF2759

Family

1,053

false

This family of proteins with unknown function appear to be restricted to Bacillales.

[]

0

[ "PFAM" ]

[ "PF10958" ]

[ "DUF2759" ]

[ 1053 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli" ]

[ 1053 ]

1

[]

0

true

Family

Protein of unknown function DUF2759

DUF2759

8

IPR024491

24,491

Selenoprotein SelK/SelG

Se_SelK/SelG

Family

2,272

false

This entry represents an eukaryotic family of selenoproteins. It includes SelK, which seems to play an important role in protecting cells from endoplasmic reticulum stress-induced apoptosis [ ]. It is required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10961", "PTHR16875" ]

[ "SelK_SelG", "" ]

[ 2237, 1684 ]

2

[]

0

[]

0

[ "PUB00056137", "PUB00056138", "PUB00095266", "PUB00095267", "PUB00095268" ]

[ "20692228", "11389138", "25368151", "23444136", "21220695" ]

[ "SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis.", "Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality.", "Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palm...

[ 2010, 2001, 2014, 2013, 2011 ]

5

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 2269 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 2, 1, 4, 3, 2, 4, 3, 8 ]

9

true

Family

Selenoprotein SelK/SelG

Se_SelK/SelG

3

IPR024492

24,492

CT_309/TC_0583-like

CT_309-like

Family

646

false

This entry includes Uncharacterized protein CT_309, Uncharacterized protein TC_0583 and Uncharacterized protein CPn_0087/CP_0687/CPj0087/CpB0087 mainly found in bacteria. They contain an all helical fold.

[]

0

[ "PFAM" ]

[ "PF10962" ]

[ "DUF2764" ]

[ 646 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 611, 35 ]

2

[]

0

true

Family

CT_309/TC_0583-like

CT_309-like

1

IPR024493

24,493

Fumarase D

FumD

Family

932

false

Fumarase D (YdhZ) catalyzes in vitro the addition of water to fumarate, forming malate [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007630", "PF10965" ]

[ "PRK10292.1", "DUF2767" ]

[ 797, 932 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.1.2", "GenProp1267", "PWY-5392", "PWY-561", "PWY-5690", "PWY-5913", "PWY-6728", "PWY-6969", "PWY-7254", "PWY-7384", "PWY-8086" ]

[ "EC:4.2.1.2", "GP:GenProp1267", "METACYC:PWY-5392", "METACYC:PWY-561", "METACYC:PWY-5690", "METACYC:PWY-5913", "METACYC:PWY-6728", "METACYC:PWY-6969", "METACYC:PWY-7254", "METACYC:PWY-7384", "METACYC:PWY-8086" ]

11

[]

0

[ "PUB00084997" ]

[ "27941785" ]

[ "Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Lederbergvirus BTP1", "human gut metagenome" ]

[ 928, 2, 1, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fumarase D

FumD

2

IPR024494

24,494

Protein of unknown function DUF2770

DUF2770

Family

648

false

Members in this family of proteins from Enterobacteria are annotated as YceO; however, currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10968" ]

[ "DUF2770" ]

[ 648 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Callosobruchus maculatus", "Gammaproteobacteria" ]

[ 1, 647 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2770

DUF2770

9

IPR024495

24,495

Protein of unknown function DUF2771

DUF2771

Family

1,230

false

This bacterial family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10969" ]

[ "DUF2771" ]

[ 1230 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Didymella rabiei", "freshwater metagenome" ]

[ 1227, 1, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF2771

DUF2771

6

IPR024496

24,496

Spore germination protein GerPE

Spore_germ_GerPE

Family

942

false

GerPE is required for the formation of functionally normal spores. It could be involved in the establishment of a normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [ ].

[]

0

[ "PFAM" ]

[ "PF10970" ]

[ "GerPE" ]

[ 942 ]

1

[]

0

[]

0

[ "PUB00044278" ]

[ "10715007" ]

[ "Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria" ]

[ 942 ]

1

[]

0

true

Family

Spore germination protein GerPE

Spore_germ_GerPE

7

IPR024497

24,497

Protein of unknown function DUF2773

DUF2773

Family

249

false

This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.

[]

0

[ "PFAM" ]

[ "PF10971" ]

[ "DUF2773" ]

[ 249 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Trichuris trichiura", "human gut metagenome" ]

[ 247, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF2773

DUF2773

1

IPR024498

24,498

Domain of unknown function DUF2786

DUF2786

Domain

6,159

false

This domain is found in proteins that have no known function.

[]

0

[ "PFAM" ]

[ "PF10979" ]

[ "DUF2786" ]

[ 6159 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanomassiliicoccus intestinalis", "Eukaryota", "Viruses", "metagenomes" ]

[ 5395, 2, 267, 415, 80 ]

5

[]

0

true

Domain

Domain of unknown function DUF2786

DUF2786

1

IPR024500

24,500

Domain of unknown function DUF3074

DUF3074

Domain

2,476

false

This domain defines a eukaryotic family of proteins that have no known function but appear to be part of the START superfamily.

[]

0

[ "PFAM" ]

[ "PF11274" ]

[ "DUF3074" ]

[ 2476 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2476 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

Domain of unknown function DUF3074

DUF3074

8

IPR024501

24,501

Protein of unknown function DUF3141

DUF3141

Family

1,922

false

This family of proteins appears to be predominantly expressed in Proteobacteria. Their function is unknown.

[]

0

[ "PFAM" ]

[ "PF11339" ]

[ "DUF3141" ]

[ 1922 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 1885, 3, 5, 29 ]

4

[]

0

true

Family

Protein of unknown function DUF3141

DUF3141

8

IPR024503

24,503

Protein of unknown function DUF3196

DUF3196

Family

183

false

The entry comprises bacterial proteins of unknown function. One of the proteins in this entry, MPN330, is thought to involved in a cellular function that has yet to be characterised. The protein has 11 helices and a novel fold. No function is currently known for this protein.

[]

0

[ "PFAM" ]

[ "PF11428" ]

[ "DUF3196" ]

[ 183 ]

1

[]

0

[ "1td6" ]

1

[]

0

[]

0

null

[ "Bacillati" ]

[ 183 ]

1

[]

0

true

Family

Protein of unknown function DUF3196

DUF3196

5

IPR024504

24,504

Uncharacterised membrane protein Ta0354, soluble domain

Unchr_Ta0354_soluble_domain

Domain

21

false

This domain is found at the C-terminal of a family of archaeal proteins annotated as membrane proteins.

[]

0

[ "PFAM" ]

[ "PF11433" ]

[ "DUF3198" ]

[ 21 ]

1

[]

0

[ "1x9b" ]

1

[]

0

[]

0

null

[ "Methanobacteriati" ]

[ 21 ]

1

[]

0

true

Domain

Uncharacterised membrane protein Ta0354, soluble domain

Unchr_Ta0354_soluble_domain

5

IPR024505

24,505

Protein of unknown function DUF3201

DUF3201

Family

50

false

This archaeal family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF11447" ]

[ "DUF3201" ]

[ 50 ]

1

[]

0

[ "1yb3" ]

1

[]

0

[]

0

null

[ "Bacteria", "Thermococcaceae" ]

[ 7, 43 ]

2

[]

0

true

Family

Protein of unknown function DUF3201

DUF3201

6

IPR024506

24,506

Protein of unknown function DUF3217

DUF3217

Family

18

false

This family of proteins with unknown function appears to be restricted to Mycoplasma and Ruminococcus spp. The structure of Uncharacterized protein MG376 homologue from Mycoplasma pneumoniae shows an OB fold with six β-strands and three loops forming a β-barrel that is capped by one α-helix [ ]. Its specific function i...

[]

0

[ "PFAM" ]

[ "PF11506" ]

[ "DUF3217" ]

[ 18 ]

1

[]

0

[ "2hql" ]

1

[ "PUB00041476" ]

[ "17348019" ]

[ "Crystal structure of a novel single-stranded DNA binding protein from Mycoplasma pneumoniae." ]

[ 2007 ]

1

[]

0

null

[ "Bacillati", "Didymodactylos carnosus" ]

[ 17, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF3217

DUF3217

3

IPR024507

24,507

AtzH-like

Family

2,415

false

This entry represents a family of bacterial proteins previously known as DUF3225, including AtzH from Pseudomonas sp. ( ). AtzH is thought to be an amidase responsible for converting 1,3-dicarboxyurea to allophanate. This protein, which adopts a dimeric assembly, shows a seven-stranded anti-parallel β-sheet and three h...

[]

0

[ "PFAM" ]

[ "PF11533" ]

[ "AtzH-like" ]

[ 2415 ]

1

[]

0

[ "2owp", "2rcd", "6bjt", "6bju", "6d63" ]

5

[ "PUB00100867" ]

[ "30399173" ]

[ "A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Natronorubrum", "metagenomes" ]

[ 2359, 33, 2, 21 ]

4

[]

0

true

Family

AtzH-like

8

IPR024508

24,508

Protein of unknown function DUF3226

DUF3226

Family

972

false

This entry represents a family of functionally uncharacterised prokaryotic proteins.

[]

0

[ "PFAM" ]

[ "PF11536" ]

[ "DUF3226" ]

[ 972 ]

1

[]

0

[ "2p62" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "metagenomes" ]

[ 53, 893, 1, 25 ]

4

[]

0

true

Family

Protein of unknown function DUF3226

DUF3226

5

IPR024509

24,509

Anti-lipopolysaccharide factor/Scygonadin

Anti-LPS_factor/Scygonadin

Family

378

false

Anti-lipopolysaccharide factor binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect, especially on the growth of Gram-negative bacteria [ , ]. This entry also includes the antibacterial protein Scygonadin, which has antibacter...

[]

0

[ "PFAM" ]

[ "PF11630" ]

[ "Anti-LPS-SCYG" ]

[ 378 ]

1

[]

0

[ "2job", "2mdl" ]

2

[ "PUB00056151", "PUB00056152", "PUB00056153" ]

[ "19490944", "21195157", "17092560" ]

[ "Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrata.", "Antibacterial activity of a synthetic peptide that mimics the LPS binding domain of Indian mud crab, Scylla serrata anti-lipopolysaccharide factor (S...

[ 2009, 2011, 2007 ]

3

[]

0

null

[ "Protostomia" ]

[ 378 ]

1

[]

0

true

Family

Anti-lipopolysaccharide factor/Scygonadin

Anti-LPS_factor/Scygonadin

5

IPR024510

24,510

Protein of unknown function DUF2589

DUF2589

Family

1,752

false

This family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF11655" ]

[ "DUF2589" ]

[ 1752 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Beauveria bassiana D1-5", "metagenomes", "uncultured Caudovirales phage" ]

[ 32, 1697, 1, 20, 2 ]

5

[]

0

true

Family

Protein of unknown function DUF2589

DUF2589

8

IPR024511

24,511

WD repeat-containing and planar cell polarity effector protein Fritz

Frtz

Family

1,893

false

Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11768", "PTHR13667" ]

[ "Frtz", "" ]

[ 1870, 1887 ]

2

[ "REACTOME" ]

[ "R-DME-450728" ]

[ "REACTOME:R-DME-450728" ]

1

[ "7q3d", "7q3e" ]

2

[ "PUB00069294" ]

[ "15654087" ]

[ "The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1893 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 3, 7, 4, 11 ]

5

true

Family

WD repeat-containing and planar cell polarity effector protein Fritz

Frtz

9

IPR024512

24,512

Small subunit of serine palmitoyltransferase-like

Ser_palmitoyltrfase_ssu-like

Family

4,383

false

Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it [ ]. The 2 ssSPT isoforms share a conserved hydrophobic ...

[]

0

[ "PFAM" ]

[ "PF11779" ]

[ "SPT_ssu-like" ]

[ 4383 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1671", "R-BTA-1660661", "R-DRE-1660661", "R-HSA-1660661", "R-MMU-1660661", "R-RNO-1660661", "R-XTR-1660661" ]

[ "GP:GenProp1671", "REACTOME:R-BTA-1660661", "REACTOME:R-DRE-1660661", "REACTOME:R-HSA-1660661", "REACTOME:R-MMU-1660661", "REACTOME:R-RNO-1660661", "REACTOME:R-XTR-1660661" ]

7

[ "6m4n", "6m4o", "7cqi", "7cqk", "7k0i", "7k0j", "7k0k", "7k0l", "7k0m", "7k0n", "7k0o", "7k0p", "7k0q", "7yiu", "7yiy", "7yj1", "7yj2", "7yjk", "7yjm", "7yjn", "7yjo" ]

21

[ "PUB00056204" ]

[ "19416851" ]

[ "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities." ]

[ 2009 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4383 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 2, 2, 2, 4, 1, 13, 4, 1, 13 ]

11

true

Family

Small subunit of serine palmitoyltransferase-like

Ser_palmitoyltrfase_ssu-like

1

IPR024514

24,514

Domain of unknown function DUF3388

DUF3388

Domain

1,565

false

This domain is found in a family of bacterial proteins that are functionally uncharacterised. Proteins in this family are typically between 261 to 275 amino acids in length and have a N-terminal ACT domain.

[]

0

[ "PFAM" ]

[ "PF11868" ]

[ "DUF3388" ]

[ 1565 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Tipula oleracea nudivirus", "bioreactor metagenome" ]

[ 1562, 1, 1, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF3388

DUF3388

6

IPR024515

24,515

Protein of unknown function DUF3397

DUF3397

Family

2,208

false

This family of bacterial proteins is currently functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF11877" ]

[ "DUF3397" ]

[ 2208 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR016945" ]

0

1

0

[ "Bacteria", "bioreactor metagenome" ]

[ 2206, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF3397

DUF3397

7

IPR024516

24,516

Mammalian cell entry, C-terminal

Mce_C

Domain

31,603

false

This entry represents a domain of unknown function found at the C terminus of many proteins in the mammalian cell entry family.

[]

0

[ "PFAM" ]

[ "PF11887" ]

[ "Mce4_CUP1" ]

[ 31603 ]

1

[]

0

[ "8fed", "8fee", "8fef" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 31557, 7, 39 ]

3

[]

0

true

Domain

Mammalian cell entry, C-terminal

Mce_C

3

IPR024517

24,517

Glycogen phosphorylase, domain of unknown function DUF3417

Glycogen_phosphorylase_DUF3417

Domain

5,669

false

This domain of unknown function is found at the N terminus of members of the glycogen phosphorylase family.

[]

0

[ "PFAM" ]

[ "PF11897" ]

[ "DUF3417" ]

[ 5669 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.1.1", "PWY-5941", "PWY-6731", "PWY-6737", "PWY-7238" ]

[ "EC:2.4.1.1", "METACYC:PWY-5941", "METACYC:PWY-6731", "METACYC:PWY-6737", "METACYC:PWY-7238" ]

5

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 5405, 2, 136, 126 ]

4

[]

0

true

Domain

Glycogen phosphorylase, domain of unknown function DUF3417

Glycogen_phosphorylase_DUF3417

5

IPR024519

24,519

Inverse autotransporter, beta-domain

IAT_beta

Domain

6,126

false

This domain is found in a group of β-barrel porin-like outer membrane proteins from enteropathogenic Gram-negative bacteria. Intimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They carry C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-...

[]

0

[ "PFAM" ]

[ "PF11924" ]

[ "IAT_beta" ]

[ 6126 ]

1

[]

0

[ "4e1s", "4e1t", "5g26" ]

3

[ "PUB00018560", "PUB00056155", "PUB00056156", "PUB00059501", "PUB00081211" ]

[ "10514372", "2172966", "3304658", "22658748", "25596886" ]

[ "Crystal structure of invasin: a bacterial integrin-binding protein.", "A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.", "Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalia...

[ 1999, 1990, 1987, 2012, 2015 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina mazei", "metagenomes" ]

[ 6092, 7, 1, 26 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Inverse autotransporter, beta-domain

IAT_beta

3

IPR024520

24,520

Protein of unknown function DUF3558

DUF3558

Family

6,607

false

This family of bacterial proteins includes members annotated as putative lipoprotein lprB. However, their function is unknown.

[]

0

[ "PFAM" ]

[ "PF12079" ]

[ "DUF3558" ]

[ 6607 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 6601, 6 ]

2

[]

0

true

Family

Protein of unknown function DUF3558

DUF3558

5

IPR024521

24,521

Arsenosugar biosynthesis radical SAM protein ArsS-like, C-terminal domain

ArsS-like_C

Domain

2,465

false

This domain at the C-terminal end of Slr0304 protein from Synechocystis sp. PCC 6803 ( ) and Slr3097 protein from Nostoc sp. PCC 7120 ( ), which were named in 2019 as ArsS, a radical SAM enzyme involved in arsenosugar biosynthesis [ ]. This domain has several conserved Cys residues, one of which is replaced by selenocy...

[]

0

[ "PFAM" ]

[ "PF12345" ]

[ "DUF3641" ]

[ 2465 ]

1

[]

0

[]

0

[ "PUB00105561" ]

[ "30525501" ]

[ "Identification of Steps in the Pathway of Arsenosugar Biosynthesis." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanohalarchaeum thermophilum", "ecological metagenomes" ]

[ 2196, 206, 1, 62 ]

4

[]

0

true

Domain

Arsenosugar biosynthesis radical SAM protein ArsS-like, C-terminal domain

ArsS-like_C

9

IPR024522

24,522

Protein of unknown function DUF3789

DUF3789

Family

574

false

This family of functionally uncharacterised bacterial proteins are approximately 40 amino acids in length. They contain two completely conserved residues (V and C) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF12664" ]

[ "DUF3789" ]

[ 574 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes", "unclassified Caudoviricetes" ]

[ 570, 2, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF3789

DUF3789

1

IPR024523

24,523

Protein of unknown function DUF3793

DUF3793

Family

1,612

false

This family of bacterial proteins is functionally uncharacterised. The proteins in this family contain two conserved sequence motifs: PHE and LGYP.

[]

0

[ "PFAM" ]

[ "PF12672" ]

[ "DUF3793" ]

[ 1612 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "Podoviridae sp. ctZ5d16", "metagenomes" ]

[ 1587, 5, 1, 19 ]

4

[]

0

true

Family

Protein of unknown function DUF3793

DUF3793

9

IPR024524

24,524

Protein of unknown function DUF3800

DUF3800

Family

6,510

false

This family of proteins is functionally uncharacterised. Some family members possess a DE motif at their N terminus and a QXXD motif at their C terminus that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF12686" ]

[ "DUF3800" ]

[ 6510 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 142, 6207, 13, 39, 109 ]

5

[]

0

true

Family

Protein of unknown function DUF3800

DUF3800

1

IPR024525

24,525

Protein of unknown function DUF3804

DUF3804

Family

57

false

Structural alignments indicate that this family of functionally uncharacterised proteins carry an NTF2-fold with a hydrophobic cavity. Family members also contain two highly conserved tryptophan residues toward their C-terminal ends.

[]

0

[ "PFAM" ]

[ "PF12707" ]

[ "DUF3804" ]

[ 57 ]

1

[]

0

[ "3hzp" ]

1

[]

0

[]

0

null

[ "Eukaryota", "Prochlorococcus marinus", "viral metagenome" ]

[ 25, 30, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF3804

DUF3804

7

IPR024526

24,526

Protein of unknown function DUF3807

DUF3807

Family

993

false

This is a family of conserved fungal proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF12720", "PTHR40642" ]

[ "DUF3807", "" ]

[ 993, 968 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 993 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function DUF3807

DUF3807

7

IPR024527

24,527

Eisosome protein 1

Eisosome1

Family

1,350

false

This family of fungal proteins represents the eisosome 1 family. Eisosome protein 1 is required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialised domains on plasma membrane and mark the site of endocytosis [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF12757", "PTHR28298" ]

[ "Eisosome1", "" ]

[ 1299, 1252 ]

2

[]

0

[]

0

[ "PUB00056207" ]

[ "20526336" ]

[ "A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1350 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Family

Eisosome protein 1

Eisosome1

5

IPR024528

24,528

Threonine/Serine exporter, ThrE

ThrE_2

Domain

15,276

false

This domain is found in a group of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminu...

[]

0

[ "PFAM" ]

[ "PF12821" ]

[ "ThrE_2" ]

[ 15276 ]

1

[]

0

[]

0

[ "PUB00075540", "PUB00075687", "PUB00075688" ]

[ "12089010", "11514515", "12879215" ]

[ "Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum.", "L-threonine export: use of peptides to identify a new translocator from Corynebacterium glutamicum.", "New ubiquitous translocator...

[ 2002, 2001, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 13035, 2172, 13, 56 ]

4

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Domain

Threonine/Serine exporter, ThrE

ThrE_2

4

IPR024529

24,529

ECF transporter, substrate-specific component

ECF_trnsprt_substrate-spec

Family

14,010

false

Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module [ ]. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-couplin...

[ "GO:0022857" ]

[ "transmembrane transporter activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12822" ]

[ "ECF_trnsprt" ]

[ 14010 ]

1

[ "GP" ]

[ "GenProp1094" ]

[ "GP:GenProp1094" ]

1

[ "3p5n", "4huq", "4rfs", "4z7f", "5d0y", "5d3m", "5jsz", "5kbw", "5kc0", "5kc4", "6fnp", "6zg3", "7nnt", "7nnu", "8bmp", "8bmq", "9kym" ]

17

[ "PUB00056162" ]

[ "18931129" ]

[ "A novel class of modular transporters for vitamins in prokaryotes." ]

[ 2009 ]

1

[]

[ "IPR017196", "IPR025720", "IPR030949" ]

0

3

0

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "metagenomes", "unclassified Caudoviricetes" ]

[ 95, 13774, 1, 138, 2 ]

5

[]

0

true

Family

ECF transporter, substrate-specific component

ECF_trnsprt_substrate-spec

6

IPR024530

24,530

Putative quorum-sensing-regulated virulence factor

QSregVF_b

Family

6,368

false

This is a family of short Pseudomonas proteins that are potential virulence factors. The structure of , a secreted protein that belongs to , has been solved and deposited as . It is predicted that these two adjacent proteins form a single transcriptional unit based on the prediction that together they interact with the...

[]

0

[ "PFAM" ]

[ "PF12843" ]

[ "QSregVF_b" ]

[ 6368 ]

1

[]

0

[]

0

[ "PUB00075641" ]

[ "24174223" ]

[ "Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 6074, 198, 35, 61 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative quorum-sensing-regulated virulence factor

QSregVF_b

6

IPR024531

24,531

Erythronate-4-phosphate dehydrogenase, dimerisation domain

Erythronate-4-P_DHase_dimer

Domain

4,325

false

This entry represents the dimerisation domain found at the C-terminal of erythronate-4-phosphate dehydrogenases [ ].

[ "GO:0046983" ]

[ "protein dimerization activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11890" ]

[ "DUF3410" ]

[ 4325 ]

1

[ "EC", "GP" ]

[ "1.1.1.290", "GenProp1633" ]

[ "EC:1.1.1.290", "GP:GenProp1633" ]

2

[ "2o4c", "3oet", "5dt9" ]

3

[ "PUB00042105" ]

[ "17217963" ]

[ "Crystal structure of D-erythronate-4-phosphate dehydrogenase complexed with NAD." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4297, 3, 25 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Erythronate-4-phosphate dehydrogenase, dimerisation domain

Erythronate-4-P_DHase_dimer

9

IPR024532

24,532

Protein of unknown function DUF3830

DUF3830

Family

2,434

false

This is a family of bacterial and archaeal proteins. The structure of one of family members, , has been characterised and shown to contain a cyclophilin-like fold.

[]

0

[ "PFAM" ]

[ "PF12903" ]

[ "DUF3830" ]

[ 2434 ]

1

[]

0

[ "3kop" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "ecological metagenomes" ]

[ 2226, 128, 69, 11 ]

4

[]

0

true

Family

Protein of unknown function DUF3830

DUF3830

2

IPR024533

24,533

Protein of unknown function DUF3834

DUF3834

Family

85

false

This family is likely to be related to solute-binding lipo-proteins.

[]

0

[ "PFAM" ]

[ "PF12916" ]

[ "DUF3834" ]

[ 85 ]

1

[]

0

[ "3mst" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Brassica cretica" ]

[ 80, 4, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF3834

DUF3834

2

IPR024534

24,534

Wadjet protein JetD, C-terminal

JetD_C

Domain

3,314

false

This is a domain found at the C-terminal of Wadjet protein JetD from Bacillus cereus. JetD is a component of the antiplasmid transformation system Wadjet type I, composed of JetA, JetB, JetC and JetD. Expression of Wadjet type I in B.subtilis (strain BEST7003) reduces the transformation efficiency of plasmid pHCMC05 [ ...

[]

0

[ "PFAM" ]

[ "PF09983" ]

[ "JetD_C" ]

[ 3314 ]

1

[]

0

[ "7til", "8b7f", "8q72" ]

3

[ "PUB00097806" ]

[ "29371424" ]

[ "Systematic discovery of antiphage defense systems in the microbial pangenome." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 3246, 4, 14, 50 ]

4

[]

0

true

Domain

Wadjet protein JetD, C-terminal

JetD_C

9

IPR024537

24,537

Domain of unknown function DUF3322

DUF3322

Domain

1,707

false

This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the N terminus.

[]

0

[ "PFAM" ]

[ "PF11795" ]

[ "DUF3322" ]

[ 1707 ]

1

[]

0

[ "7til", "8b7f", "8q72" ]

3

[]

0

[]

0

null

[ "Bacteria", "Linnemannia gamsii", "Methanosarcinales", "unclassified sequences" ]

[ 1672, 1, 4, 30 ]

4

[]

0

true

Domain

Domain of unknown function DUF3322

DUF3322

8

IPR024538

24,538

Protein of unknown function DUF3878

DUF3878

Family

230

false

This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].

[]

0

[ "PFAM" ]

[ "PF12994" ]

[ "DUF3878" ]

[ 230 ]

1

[]

0

[]

0

[ "PUB00056060" ]

[ "19321416" ]

[ "Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla." ]

[ 2009 ]

1

[]

0

null

[ "Clostridia", "human gut metagenome" ]

[ 229, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF3878

DUF3878

6

IPR024540

24,540

Protein of unknown function DUF3879

DUF3879

Family

253

false

This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].

[]

0

[ "PFAM" ]

[ "PF12995" ]

[ "DUF3879" ]

[ 253 ]

1

[]

0

[]

0

[ "PUB00056060" ]

[ "19321416" ]

[ "Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla." ]

[ 2009 ]

1

[]

0

null

[ "Bacillota", "human gut metagenome" ]

[ 250, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF3879

DUF3879

7

IPR024541

24,541

Protein of unknown function DUF3881

DUF3881

Family

437

false

This entry represents proteins of unknown function found primarily in Firmicutes. The Eubacterium rectale gene appears to be upregulated in the presence of Bacteroides thetaiotaomicron compared to growth in pure culture [ ].

[]

0

[ "PFAM" ]

[ "PF12997" ]

[ "DUF3881" ]

[ 437 ]

1

[]

0

[]

0

[ "PUB00056060" ]

[ "19321416" ]

[ "Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Glossina morsitans morsitans", "metagenomes" ]

[ 432, 1, 4 ]

3

[]

0

true

Family

Protein of unknown function DUF3881

DUF3881

8

IPR024542

24,542

Spore protein YkvP, N-terminal domain

YkvP_N

Domain

317

false

This domain is found at the N-terminal end of Spore protein YkvP from Bacillus subtilis and similar sequences from firmicutes. Its specific function is not known. YkvP is a spore protein that contains a motif conserved among cell wall binding proteins. Its expression is dependent on both SigK and GerE transcription fac...

[]

0

[ "PFAM" ]

[ "PF12996" ]

[ "YkvP_N" ]

[ 317 ]

1

[]

0

[]

0

[ "PUB00056060", "PUB00057269", "PUB00062761", "PUB00160290" ]

[ "19321416", "7592393", "11011148", "31502725" ]

[ "Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla.", "Adjacent and divergently oriented operons under the control of the sporulation regulatory protein GerE in Bacillus subtilis.", "Synthesis and characterization of the spore proteins of Bacillus subtilis YdhD,...

[ 2009, 1995, 2000, 2019 ]

4

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 314, 3 ]

2

[]

0

true

Domain

Spore protein YkvP, N-terminal domain

YkvP_N

1

IPR024543

24,543

Autophagy protein Atg19/Atg34, C-terminal

Atg19/Atg34_C

Domain

81

false

Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are sequestered into double-membrane vesicles to form the autophagosome. The contents of the autophagosome are delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of t...

[]

0

[ "PFAM" ]

[ "PF12744" ]

[ "ATG19" ]

[ 81 ]

1

[]

0

[ "2kzb", "2kzk" ]

2

[ "PUB00056061", "PUB00056200", "PUB00056201", "PUB00056202" ]

[ "17192412", "20639194", "20659891", "16247502" ]

[ "Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy.", "Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.", "Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 a...

[ 2007, 2010, 2010, 2005 ]

4

[]

0

null

[ "Saccharomycetes" ]

[ 81 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Domain

Autophagy protein Atg19/Atg34, C-terminal

Atg19/Atg34_C

3

IPR024544

24,544

Domain of unknown function DUF3858

DUF3858

Domain

378

false

This domain of unknown function is structurally similar to part of neuropilin-2. The proteins it occurs in have not yet been functionally characterised.

[]

0

[ "PFAM" ]

[ "PF12970" ]

[ "DUF3858" ]

[ 378 ]

1

[]

0

[ "3kd4" ]

1

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 371, 7 ]

2

[]

0

true

Domain

Domain of unknown function DUF3858

DUF3858

2

IPR024545

24,545

Mto1-like, Mto2p-binding domain

Mto1-like_Mto2p-bd

Domain

884

false

This domain is found at the C terminus of Gamma tubulin complex adapter mto1 from yeast, Anucleate primary sterigmata protein B from Emericella nidulans (ApsB) and similar fungal sequences. Mto1 is an spindle pole body (SPB) component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque [ , , ...

[]

0

[ "PFAM" ]

[ "PF12808" ]

[ "Mto2_bdg" ]

[ 884 ]

1

[]

0

[]

0

[ "PUB00056062", "PUB00056063", "PUB00153155", "PUB00153156", "PUB00153157" ]

[ "15120067", "15800064", "10094631", "15659644", "19001497" ]

[ "Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p.", "Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring.", "Increased nuclear traffic chaos in ...

[ 2004, 2005, 1998, 2005, 2008 ]

5

[]

0

null

[ "Eukaryota" ]

[ 884 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

Mto1-like, Mto2p-binding domain

Mto1-like_Mto2p-bd

5

IPR024548

24,548

Copper type II ascorbate-dependent monooxygenase, C-terminal

Cu2_monoox_C

Domain

10,085

false

Copper type II, ascorbate-dependent monooxygenases [ ] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase ( ) and peptidyl-glycine alpha-amidating monooxygenase ( ). There are a few regions of seq...

[]

0

[ "PFAM" ]

[ "PF03712" ]

[ "Cu2_monoox_C" ]

[ 10085 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.17", "GenProp1606", "R-DME-209905", "R-HSA-209905", "R-MMU-209905", "R-RNO-209905" ]

[ "EC:1.14.17", "GP:GenProp1606", "REACTOME:R-DME-209905", "REACTOME:R-HSA-209905", "REACTOME:R-MMU-209905", "REACTOME:R-RNO-209905" ]

6

[ "1opm", "1phm", "1sdw", "1yi9", "1yip", "1yjk", "1yjl", "3mib", "3mic", "3mid", "3mie", "3mif", "3mig", "3mih", "3mlj", "3mlk", "3mll", "3phm", "4e4z", "4zel", "5wja", "5wkw", "5wm0", "6ala", "6alv", "6amp", "6an3", "6ao6", "6ay0", "6nck", "8dsj", "8dsl"...

33

[ "PUB00001578" ]

[ "2792366" ]

[ "Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain." ]

[ 1989 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 728, 9318, 39 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 18, 8, 11, 9, 19 ]

6

true

Domain

Copper type II ascorbate-dependent monooxygenase, C-terminal

Cu2_monoox_C

1

IPR024550

24,550

TFIIEalpha/SarR/Rpc3 HTH domain

TFIIEa/SarR/Rpc3_HTH_dom

Domain

5,975

false

The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation, together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits, TFIIE-alpha and TFIIE-beta, and joins the preinitiation complex after RNA polymerase II and TFIIF [ ].

[]

0

[ "PFAM" ]

[ "PF02002" ]

[ "TFIIE_alpha" ]

[ 5975 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-674695", "R-BTA-6807505", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953", "R-BTA-76042", "R-DDI-674695", "R-DDI-6807505", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6807505", "R-HSA-73776", ...

[ "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-73776", "REACTOME:R-BTA-73779", "REACTOME:R-BTA-75953", "REACTOME:R-BTA-76042", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6807505", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73779", "REACTOME:R-DDI-75953", "REACTOME:R-DDI-76042", ...

39

[ "1q1h", "5fmf", "5fyw", "5fz5", "5gpy", "5iy6", "5iy7", "5iy8", "5iy9", "5iya", "5iyb", "5iyc", "5iyd", "5oqj", "5oqm", "5sva", "6gyl", "6gym", "6kf4", "6kf9", "6o9l", "6pln", "6xjf", "7eg9", "7ega", "7egb", "7egc", "7ena", "7enc", "7lbm", "7ml0", "7ml1"...

77

[ "PUB00005696", "PUB00005704", "PUB00005802" ]

[ "1956403", "1454543", "9389475" ]

[ "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE.", "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences.", "The complete genome sequence of the hyperthermophilic, sulphate-reducing a...

[ 1991, 1992, 1997 ]

3

[]

[ "IPR017919" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Methanocaldococcus fervens tailed virus 1", "metagenomes" ]

[ 905, 37, 4994, 1, 38 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 19, 1, 3, 1, 5, 4, 1, 3, 2, 1, 1, 16 ]

12

true

Domain

TFIIEalpha/SarR/Rpc3 HTH domain

TFIIEa/SarR/Rpc3_HTH_dom

8

IPR024551

24,551

Aspartate aminotransferase Ic

AspAT_Ic

Family

3,279

false

Aminotransferases (ATs) are pyridoxal phosphate (PLP)-dependent enzymes that catalyze the reversible transfer of nitrogen from an amino donor to a keto acid amino acceptor. ATs have been classified into five classes by evolutionary relationship. Aspartate aminotransferase (AspAT) belongs to class I ATs. AspAT catalyzes...

[ "GO:0004069" ]

[ "L-aspartate:2-oxoglutarate aminotransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12897" ]

[ "Asp_aminotransf" ]

[ 3279 ]

1

[]

0

[ "3d6k", "3ez1", "3ppl", "5c6u", "5hxx", "5iwq", "6u78", "6u7a" ]

8

[ "PUB00094541", "PUB00094542", "PUB00094544" ]

[ "32327655", "27355211", "8513804" ]

[ "Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.", "Structural Insights into a Novel Class of Aspartate Aminotransferase from Corynebacterium glutamicum.", "Aminotransferases: demonstration of homology and division into evolutionary subgroups." ]

[ 2020, 2016, 1993 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3220, 7, 52 ]

3

[]

0

true

Family

Aspartate aminotransferase Ic

AspAT_Ic

8

IPR024552

24,552

Domain of Unknown Function DUF3856

DUF3856

Domain

36

false

This domain of unknown function is found in a small group of tetratricopeptide-like proteins, which includes the uncharacterised protein . The structure of Q8KAL8 is known and belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family.

[]

0

[ "PFAM" ]

[ "PF12968" ]

[ "DUF3856" ]

[ 36 ]

1

[]

0

[ "2hr2" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)", "hydrocarbon metagenome" ]

[ 26, 8, 1, 1 ]

4

[]

0

true

Domain

Domain of Unknown Function DUF3856

DUF3856

8

IPR024554

24,554

PX domain-containing protein LEC1-like, C-terminal

LEC1-like_C

Domain

2,721

false

The function of this domain is not known, and it is found in fungal proteins, including LEC1/YPR097W from budding yeast and C663.15c/C1450.12 from fission yeast. They contain this domain, known as DUF3818 and PXA domains. LEC1 is a phosphoinositide-binding protein that plays a role in regulation of ergosterol distribut...

[]

0

[ "PFAM" ]

[ "PF12825" ]

[ "DUF3818" ]

[ 2721 ]

1

[]

0

[]

0

[ "PUB00158969" ]

[ "36354737" ]

[ "Systematic analysis of membrane contact sites in <i>Saccharomyces cerevisiae</i> uncovers modulators of cellular lipid distribution." ]

[ 2022 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2721 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 2 ]

3

true

Domain

PX domain-containing protein LEC1-like, C-terminal

LEC1-like_C

8

IPR024555

24,555

PX-associated domain

PX-associated

Domain

2,552

false

The function of this domain is not known, but it is almost always found N-terminal to a PX domain ( ).

[]

0

[ "PFAM" ]

[ "PF12828" ]

[ "PXB" ]

[ 2552 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2552 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 2 ]

3

true

Domain

PX-associated domain

PX-associated

2

IPR024556

24,556

Protein of unknown function DUF3599

DUF3599

Family

140

false

This family of bacterial proteins includes phage-like element PBSX protein xkdH from Bacillus subtilis. The function of the family is unknown.

[]

0

[ "PFAM" ]

[ "PF12206" ]

[ "DUF3599" ]

[ 140 ]

1

[]

0

[ "3f3b" ]

1

[]

0

[]

0

null

[ "Bacillota", "Caudoviricetes" ]

[ 136, 4 ]

2

[]

0

true

Family

Protein of unknown function DUF3599

DUF3599

9

IPR024557

24,557

CCR4-NOT transcription complex subunit 1, domain 4

CNOT1_dom_4

Domain

6,438

false

The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the fiv...

[]

0

[ "PFAM" ]

[ "PF12842" ]

[ "DUF3819" ]

[ 6438 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-6804115", "R-HSA-429947", "R-HSA-6804115", "R-HSA-9820841", "R-MMU-429947", "R-MMU-6804115", "R-XTR-429947", "R-XTR-6804115" ]

[ "REACTOME:R-DRE-6804115", "REACTOME:R-HSA-429947", "REACTOME:R-HSA-6804115", "REACTOME:R-HSA-9820841", "REACTOME:R-MMU-429947", "REACTOME:R-MMU-6804115", "REACTOME:R-XTR-429947", "REACTOME:R-XTR-6804115" ]

8

[ "4cru", "4crv", "4ct6", "4ct7", "4cv5", "5ona", "9fl8" ]

7

[ "PUB00010586", "PUB00044101", "PUB00044102", "PUB00044103" ]

[ "11696541", "10637334", "12957374", "18430587" ]

[ "Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.", "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.", "Global control of gene expression in yeast by the Ccr4-Not complex.", "Biophysic...

[ 2002, 2000, 2003, 2008 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6438 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 5, 4, 5, 1, 11, 4, 1, 1, 131 ]

12

true

Domain

CCR4-NOT transcription complex subunit 1, domain 4

CNOT1_dom_4

4

IPR024558

24,558

ComZ

Family

423

false

ComZ, which contains a leucine zipper motif, negatively regulates transcription of the ComG operon [ ].

[]

0

[ "PFAM" ]

[ "PF10815" ]

[ "ComZ" ]

[ 423 ]

1

[]

0

[]

0

[ "PUB00052319" ]

[ "10940045" ]

[ "Bacillus subtilis comZ (yjzA) negatively affects expression of comG but not comK." ]

[ 2000 ]

1

[]

0

null

[ "Bacillales" ]

[ 423 ]

1

[]

0

true

Family

ComZ

4

IPR024559

24,559

Domain of unknown function DUF3846

DUF3846

Domain

1,824

false

A family of uncharacterised proteins found by clustering human gut metagenomic sequences [ ]. In a few cases it is found fused to the C terminus of ArdA ( ). ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification [ ].

[]

0

[ "PFAM" ]

[ "PF12957" ]

[ "DUF3846" ]

[ 1824 ]

1

[]

0

[]

0

[ "PUB00013083", "PUB00055601" ]

[ "12618468", "20532204" ]

[ "Plasmid R16 ArdA protein preferentially targets restriction activity of the type I restriction-modification system EcoKI.", "Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families." ]

[ 2003, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina mazei", "Viruses", "metagenomes" ]

[ 1678, 2, 1, 99, 44 ]

5

[]

0

true

Domain

Domain of unknown function DUF3846

DUF3846

5

IPR024560

24,560

UPF0313, C-terminal

UPF0313_C

Domain

7,345

false

This domain tends to occur to the C terminus of a radical SAM domain ( ) in members of the uncharacterised protein family UPF0313.

[]

0

[ "PFAM" ]

[ "PF11842" ]

[ "DUF3362" ]

[ 7345 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 136, 7100, 6, 2, 101 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

UPF0313, C-terminal

UPF0313_C

6

IPR024561

24,561

Alpha-1,6-glucosidases, pullulanase-type, C-terminal

Pullul_strch_C

Domain

3,940

false

This entry represents the uncharacterised C-terminal domain of secreted (or membrane-anchored) pullulanases of Gram-negative bacteria and pullulanase-type starch debranching enzymes of plants. Both enzymes hydrolyse alpha-1,6 glycosidic linkages. Pullulan is an unusual, industrially important polysaccharide in which sh...

[]

0

[ "PFAM" ]

[ "PF11852" ]

[ "Pullul_strch_C" ]

[ 3940 ]

1

[]

0

[ "2fgz", "2fh6", "2fh8", "2fhb", "2fhc", "2fhf", "2y4s", "2y5e", "2yoc", "4aio", "4cvw", "4j3s", "4j3t", "4j3u", "4j3v", "4j3w", "4j3x", "5yn2", "5yn7", "5yna", "5ync", "5ynd", "5yne", "5ynh", "6j33", "6j34", "6j35", "6j4h" ]

28

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3210, 723, 7 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 6, 11 ]

3

true

Domain

Alpha-1,6-glucosidases, pullulanase-type, C-terminal

Pullul_strch_C

8

IPR024563

24,563

Uncharacterised protein family YqhR

YqhR

Family

1,241

false

This family of proteins is conserved in the Bacillaceae family of the Firmicutes. Their function is not known.

[]

0

[ "PFAM" ]

[ "PF11085" ]

[ "YqhR" ]

[ 1241 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 1241 ]

1

[]

0

true

Family

Uncharacterised protein family YqhR

YqhR

1

IPR024564

24,564

Nitrogenase molybdenum-iron protein beta chain, N-terminal

Nase_Mo-Fe_CF_bsu_N

Domain

1,508

false

The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer enco...

[]

0

[ "PFAM" ]

[ "PF11844" ]

[ "DUF3364" ]

[ 1508 ]

1

[ "EC" ]

[ "1.18.6.1" ]

[ "EC:1.18.6.1" ]

1

[ "1fp4", "1g20", "1g21", "1h1l", "1l5h", "1m1n", "1m1y", "1m34", "1n2c", "1qgu", "1qh1", "1qh8", "2afh", "2afi", "2min", "3k1a", "3min", "3u7q", "4nd8", "4tku", "4tkv", "4wna", "4wza", "4wzb", "4xpi", "5bvg", "5bvh", "5cx1", "5koh", "5koj", "5vq4", "6bbl"...

91

[ "PUB00033167", "PUB00033168", "PUB00033169", "PUB00033170", "PUB00080687", "PUB00080688" ]

[ "10903367", "12823187", "8226614", "7876209", "11913144", "8286368" ]

[ "Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.", "Nitrogenase gene diversity and microbial community structure: a cross-system comparison.", "Nitrogenase metalloclusters: structures, organization, and synthesis.", "Characteristics of NIFNE in Azoto...

[ 2000, 2003, 1993, 1995, 2002, 1994 ]

6

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1488, 20 ]

2

[]

0

true

Domain

Nitrogenase molybdenum-iron protein beta chain, N-terminal

Nase_Mo-Fe_CF_bsu_N

6

IPR024565

24,565

Orexigenic neuropeptide QRFP/P518

P518

Family

594

false

QRFP/P518 has a direct role in maintaining bone mineral density [ ]. QRFP has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice [ ]. The C-terminal 28 residues are the functional neuropeptide 26RFa [ ].

[ "GO:0031854" ]

[ "orexigenic neuropeptide QRFP receptor binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF11109", "PTHR36476" ]

[ "RFamide_26RFa", "" ]

[ 594, 478 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-389397", "R-HSA-416476", "R-MMU-389397", "R-MMU-416476", "R-RNO-389397", "R-RNO-416476" ]

[ "REACTOME:R-HSA-389397", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-389397", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-389397", "REACTOME:R-RNO-416476" ]

6

[ "8wz2", "8zh8" ]

2

[ "PUB00056065", "PUB00056066", "PUB00056067" ]

[ "17869477", "16543370", "14657341" ]

[ "P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse.", "RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice.", "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity." ]

[ 2007, 2006, 2003 ]

3

[]

0

null

[ "Chordata" ]

[ 594 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 2 ]

4

true

Family

Orexigenic neuropeptide QRFP/P518

P518

7

IPR024566

24,566

Colicin, receptor domain

Colicin_R_dom

Domain

123

false

Bacteriocins are protein antibiotics that kill bacteria closely related to the producing species. Colicins are a subgroup of bacteriocins that are produced by and target Escherichia coli. The lethal action of most colicins is exerted either by formation of a pore in the cytoplasmic membrane of the target cell, or by an...

[]

0

[ "PFAM" ]

[ "PF11570" ]

[ "E2R135" ]

[ 123 ]

1

[]

0

[ "1jch", "1ujw", "2b5u", "2ysu", "7nsu" ]

5

[ "PUB00014773", "PUB00014774" ]

[ "12423783", "12409205" ]

[ "Mechanisms of colicin binding and transport through outer membrane porins.", "Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 120, 3 ]

2

[]

0

true

Domain

Colicin, receptor domain

Colicin_R_dom

5

IPR024569

24,569

Lactate utilization protein B, C-terminal

LutB_C

Domain

7,785

false

This entry represents the C-terminal domain of Lactate utilization protein B, a family of 4Fe-4S, iron-sulphur cluster binding proteins. These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind...

[]

0

[ "PFAM" ]

[ "PF11870" ]

[ "LutB_C" ]

[ 7785 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote AD1000_85_G06" ]

[ 7733, 7, 44, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Lactate utilization protein B, C-terminal

LutB_C

1

IPR024570

24,570

Murein transglycosylase-C, N-terminal

Murein_transglycosylaseC_N

Domain

2,512

false

Membrane-bound lytic murein transglycosylase C (also known as murein hydrolase C), is a murein-degrading enzyme that may play a role in the recycling of muropeptides during cell elongation and/or cell division. This entry represents the N-terminal domain, whose function is currently not known.

[]

0

[ "PFAM" ]

[ "PF11873" ]

[ "Mltc_N" ]

[ 2512 ]

1

[]

0

[ "4c5f", "4cfo", "4cfp", "4chx" ]

4

[]

0

[]

0

null

[ "Bacteria", "Glossina", "metagenomes" ]

[ 2493, 3, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Murein transglycosylase-C, N-terminal

Murein_transglycosylaseC_N

8

IPR024571

24,571

ERAP1-like C-terminal domain

ERAP1-like_C_dom

Domain

38,970

false

This large domain is composed of 16 α helices organised as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.

[]

0

[ "PFAM" ]

[ "PF11838" ]

[ "ERAP1_C" ]

[ 38970 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.4.11", "GenProp1664", "R-BTA-983170", "R-CEL-2022377", "R-CEL-983168", "R-CEL-983170", "R-GGA-6798695", "R-HSA-1236977", "R-HSA-1445148", "R-HSA-2022377", "R-HSA-6798695", "R-HSA-983168", "R-HSA-983170", "R-MMU-1236977", "R-MMU-2022377", "R-MMU-6798695", "R-MMU-983168", "R-MMU-9...

[ "EC:3.4.11", "GP:GenProp1664", "REACTOME:R-BTA-983170", "REACTOME:R-CEL-2022377", "REACTOME:R-CEL-983168", "REACTOME:R-CEL-983170", "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-1236977", "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-983168", "REAC...

26

[ "1z1w", "1z5h", "2yd0", "3mdj", "3q7j", "3qnf", "3rjo", "3se6", "4e36", "4f5c", "4fke", "4fkh", "4fkk", "4fyq", "4fyr", "4fys", "4fyt", "4hom", "4jbs", "4kx7", "4kx8", "4kx9", "4kxa", "4kxb", "4kxc", "4kxd", "4naq", "4nz8", "4ou3", "4p8q", "4pj6", "4wz9"...

96

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 197, 11655, 26822, 8, 288 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 10, 34, 60, 63, 21, 2, 12, 35, 3, 1, 27 ]

12

true

Domain

ERAP1-like C-terminal domain

ERAP1-like_C_dom

6

IPR024572

24,572

Nickel/cobalt homeostasis protein RcnB

RcnB

Family

6,252

false

RcnB is a family of Proteobacteria proteins. RcnB is required for maintaining metal ion homeostasis, in conjunction with the efflux pump RcnA, family NicO [ , , ].

[]

0

[ "PFAM" ]

[ "PF11776" ]

[ "RcnB" ]

[ 6252 ]

1

[]

0

[ "2l1s" ]

1

[ "PUB00075667", "PUB00075668", "PUB00075669" ]

[ "15805538", "1695638", "21665978" ]

[ "Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli.", "Craniofacial dysmorphogenesis in transgenic mice.", "RcnB is a periplasmic protein essential for maintaining intracellular Ni and Co concentrations in Escherichia coli." ]

[ 2005, 1990, 2011 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6227, 7, 18 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Nickel/cobalt homeostasis protein RcnB

RcnB

3

IPR024573

24,573

Domain of unknown function DUF3333

DUF3333

Domain

3,234

false

This N-terminal domain is functionally uncharacterised and it is found in proteins annotated as putative phosphate ABC transporter permease proteins. This presumed domain is typically between 116 to 159 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11812" ]

[ "DUF3333" ]

[ 3234 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3200, 11, 23 ]

3

[]

0

true

Domain

Domain of unknown function DUF3333

DUF3333

2

IPR024574

24,574

ELMO, armadillo-like helical domain

ELMO_ARM

Domain

6,572

false

This domain is found in eukaryotes and predominantly in ELMO (Engulfment and cell motility) proteins where it may play an important role in defining the functions of the ELMO family members and may be functionally linked to the ELMO domain in these proteins [ ].

[]

0

[ "PFAM" ]

[ "PF11841" ]

[ "ELMO_ARM" ]

[ 6572 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-8849471", "R-CEL-9013408", "R-HSA-164944", "R-HSA-2029482", "R-HSA-4420097", "R-HSA-8849471", "R-HSA-9013408", "R-HSA-9664422", "R-MMU-2029482", "R-MMU-4420097", "R-MMU-8849471", "R-MMU-9013408" ]

[ "REACTOME:R-CEL-8849471", "REACTOME:R-CEL-9013408", "REACTOME:R-HSA-164944", "REACTOME:R-HSA-2029482", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-8849471", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9664422", "REACTOME:R-MMU-2029482", "REACTOME:R-MMU-4420097", "REACTOME:R-MMU-8849471", "REACTOME...

12

[ "6idx", "6ie1", "6tgb", "6tgc", "7dpa", "8jhk", "8xm7", "8zj2", "8zji", "8zjj", "8zjk", "8zjl", "8zjm" ]

13

[ "PUB00073882" ]

[ "23014990" ]

[ "ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6572 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 17, 2, 14, 8, 1, 14 ]

7

true

Domain

ELMO, armadillo-like helical domain

ELMO_ARM

6

IPR024575

24,575

Cloacin/colicin

Cloacin_colicin

Family

196

false

Bacteriocins are protein antibiotics that kill bacteria closely related to the producing species. Colicins are a subgroup of bacteriocins that are produced by and target Escherichia coli. The lethal action of most colicins is exerted either by formation of a pore in the cytoplasmic membrane of the target cell, or by an...

[ "GO:0005727" ]

[ "extrachromosomal circular DNA" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01295" ]

[ "CLOACIN" ]

[ 196 ]

1

[]

0

[ "1jch", "2axc", "2b5u", "5ew5", "7nst", "7nsu" ]

6

[ "PUB00014773", "PUB00014774" ]

[ "12423783", "12409205" ]

[ "Mechanisms of colicin binding and transport through outer membrane porins.", "Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 191, 5 ]

2

[]

0

true

Family

Cloacin/colicin

Cloacin_colicin

2

IPR024576

24,576

Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381

rRNA_MeTfrase_Spb1_DUF3381

Domain

4,542

false

This uncharacterised domain is found in the central region of fungal SPB1 and mammalian homologue FTSJ3. SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [ ]. In Saccharomyces cerevisiae, it specifically methyla...

[]

0

[ "PFAM" ]

[ "PF11861" ]

[ "DUF3381" ]

[ 4542 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

149

[ "6elz", "6em5", "6ylx", "7nac", "7nad", "7naf", "7ohr", "7ohv", "7r6k", "7r72", "7r7a", "7u0h", "8esq", "8esr", "8etc", "8etj", "8fkp", "8fkq", "8fkr", "8fks", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8i9t", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z"...

35

[ "PUB00016377", "PUB00056208", "PUB00068804", "PUB00068805" ]

[ "10556316", "15546625", "10648622", "22195017" ]

[ "Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae.", "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage.", "Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind ...

[ 1999, 2004, 2000, 2011 ]

4

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4541, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 3, 2, 1, 2, 1, 1, 4, 1, 1, 1, 13 ]

12

true

Domain

Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381

rRNA_MeTfrase_Spb1_DUF3381

7

IPR024578

24,578

Homez, homeobox domain

Homez_homeobox_dom

Domain

1,945

false

Homez contains three atypical homeobox domains, two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus [ ]. It is thought that the first leucine zipper an...

[]

0

[ "PFAM" ]

[ "PF11569" ]

[ "Homez" ]

[ 1945 ]

1

[]

0

[ "2ys9" ]

1

[ "PUB00056069" ]

[ "12925734" ]

[ "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage." ]

[ 2003 ]

1

[]

0

null

[ "Lactobacillus", "Vertebrata" ]

[ 8, 1937 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 11, 7, 12 ]

4

true

Domain

Homez, homeobox domain

Homez_homeobox_dom

8

IPR024579

24,579

Bcl-2-interacting killer

Bcl2-int_killer

Family

266

false

Bcl-2-interacting killer promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family, Bax and Bak. Its death-promoting activity can be suppressed by coexpression of Bcl-2, Bcl-XL, EBV-BHRF1 and E1B-19kDa proteins, suggesting that it may be a common target for both cellular and viral anti-...

[ "GO:0006915" ]

[ "apoptotic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF12201", "PTHR15018" ]

[ "bcl-2I13", "" ]

[ 237, 201 ]

2

[]

0

[]

0

[ "PUB00056070" ]

[ "7478623" ]

[ "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins." ]

[ 1995 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 266 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 4, 5 ]

4

true

Family

Bcl-2-interacting killer

Bcl2-int_killer

6

IPR024580

24,580

Dishevelled C-terminal

Dishevelled_C-dom

Domain

3,998

false

Wnt proteins constitute a large family of secreted signalling molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Wg) (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cel...

[]

0

[ "PFAM" ]

[ "PF12316" ]

[ "Dsh_C" ]

[ 3998 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-201681", "R-HSA-201688", "R-HSA-2028269", "R-HSA-4086400", "R-HSA-4608870", "R-HSA-4641258", "R-HSA-4641262", "R-HSA-5099900", "R-HSA-5368598", "R-HSA-5663220", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-9673324", "R-MMU-201688", "R-MMU-2028269", "R-MMU-4086400", "R-MMU-4608870"...

[ "REACTOME:R-HSA-201681", "REACTOME:R-HSA-201688", "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-4086400", "REACTOME:R-HSA-4608870", "REACTOME:R-HSA-4641258", "REACTOME:R-HSA-4641262", "REACTOME:R-HSA-5099900", "REACTOME:R-HSA-5368598", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-8856825", "REACTOME:...

35

[ "8wm9", "8wma" ]

2

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011235", "PUB00060615" ]

[ "9891778", "10967351", "10733430", "12072470", "9867820" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alle...

[ 1998, 2000, 2000, 2002, 1999 ]

5

[]

0

null

[ "Eukaryota", "Vreelandella" ]

[ 3996, 2 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 26, 20, 8, 9 ]

4

true

Domain

Dishevelled C-terminal

Dishevelled_C-dom

4

IPR024581

24,581

Tbk1/Ikki binding domain

TBD

Domain

2,207

false

The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases which is essential for poly(I:C)-induced IRF activation [ ]. The domain is found in the SINTBAD, TANK and NAP1 proteins. This domain is predicted to form an α-helix with residues essential for kinase binding clustering on one side [ ].

[]

0

[ "PFAM" ]

[ "PF12845" ]

[ "TBD" ]

[ 2207 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9013973", "R-HSA-933541", "R-HSA-936964", "R-HSA-9824878", "R-HSA-9828211", "R-MMU-936964", "R-MMU-9824878" ]

[ "REACTOME:R-HSA-9013973", "REACTOME:R-HSA-933541", "REACTOME:R-HSA-936964", "REACTOME:R-HSA-9824878", "REACTOME:R-HSA-9828211", "REACTOME:R-MMU-936964", "REACTOME:R-MMU-9824878" ]

7

[ "5ep6" ]

1

[ "PUB00056071" ]

[ "17568778" ]

[ "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK." ]

[ 2007 ]

1

[]

0

null

[ "Vertebrata" ]

[ 2207 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 12, 13, 12 ]

4

true

Domain

Tbk1/Ikki binding domain

TBD

5

IPR024583

24,583

Voltage-gated Na+ ion channel, cytoplasmic domain

Na_trans_cytopl

Domain

11,499

false

This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes.

[]

0

[ "PFAM" ]

[ "PF11933" ]

[ "Na_trans_cytopl" ]

[ 11499 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892", "R-HSA-9717207" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-9717207" ]

3

[ "6j8e", "6j8g", "6j8h", "6j8i", "6j8j", "6lqa", "7dtc", "7dtd", "7w77", "7w7f", "7w9k", "7w9l", "7w9m", "7w9p", "7w9t", "7xm9", "7xmf", "7xmg", "7xve", "7xvf", "8fhd", "8g1a", "8gz1", "8gz2", "8i5b", "8i5g", "8i5x", "8i5y", "8j4f", "8s9b", "8s9c", "8thg"...

41

[]

0

[]

0

null

[ "Bilateria" ]

[ 11499 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 34, 57, 43, 30, 35 ]

5

true

Domain

Voltage-gated Na+ ion channel, cytoplasmic domain

Na_trans_cytopl

1

IPR024584

24,584

Tuberin, N-terminal

Tuberin_N

Domain

4,535

false

This entry represents the N-terminal domain of tuberin which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF11864" ]

[ "DUF3384" ]

[ 4535 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1632852", "R-HSA-165181", "R-HSA-198323", "R-HSA-380972", "R-HSA-5628897", "R-HSA-5674400", "R-HSA-8854214", "R-MMU-1632852", "R-MMU-165181", "R-MMU-198323", "R-MMU-380972", "R-MMU-5628897", "R-MMU-8854214", "R-RNO-1632852", "R-RNO-165181", "R-RNO-198323", "R-RNO-380972", "R...

[ "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-165181", "REACTOME:R-HSA-198323", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-5674400", "REACTOME:R-HSA-8854214", "REACTOME:R-MMU-1632852", "REACTOME:R-MMU-165181", "REACTOME:R-MMU-198323", "REACTOME:R-MMU-380972", "REACTOME:R-MM...

23

[ "5hiu", "7dl2", "9ce3" ]

3

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4535 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 8, 41, 12, 2, 7, 2 ]

7

true

Domain

Tuberin, N-terminal

Tuberin_N

7

IPR024585

24,585

Serine/threonine-protein kinase mTOR domain

mTOR_dom

Domain

5,500

false

This entry represents a domain found in serine/threonine-protein kinase mTOR (target of rapamycin), a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals [ , , , , ]. In Saccharomyces cerevisiae, the TOR proteins, TOR1 and TOR2, reg...

[]

0

[ "PFAM", "SMART" ]

[ "PF11865", "SM01346" ]

[ "mTOR_dom", "DUF3385" ]

[ 5491, 5346 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.11.1", "R-CEL-1257604", "R-CEL-1632852", "R-CEL-165159", "R-CEL-166208", "R-CEL-3371571", "R-CEL-380972", "R-CEL-389357", "R-CEL-5218920", "R-CEL-5628897", "R-CEL-6804757", "R-CEL-8943724", "R-CEL-9639288", "R-CEL-9856530", "R-DDI-1257604", "R-DDI-1632852", "R-DDI-165159", "R-...

[ "EC:2.7.11.1", "REACTOME:R-CEL-1257604", "REACTOME:R-CEL-1632852", "REACTOME:R-CEL-165159", "REACTOME:R-CEL-166208", "REACTOME:R-CEL-3371571", "REACTOME:R-CEL-380972", "REACTOME:R-CEL-389357", "REACTOME:R-CEL-5218920", "REACTOME:R-CEL-5628897", "REACTOME:R-CEL-6804757", "REACTOME:R-CEL-8943724...

93

[ "5fvm", "5h64", "5zcs", "6bcu", "6bcx", "6emk", "6sb0", "6sb2", "6zwm", "6zwo", "7owg", "7pe7", "7pe8", "7pe9", "7pea", "7peb", "7pec", "7pqh", "7tzo", "7uxc", "7uxh", "8era", "8rch", "8rck", "8rcn", "9ed4", "9ed7", "9ed8", "9f44", "9f45" ]

30

[ "PUB00015261", "PUB00103870", "PUB00151555", "PUB00151556", "PUB00151557", "PUB00151558", "PUB00151559", "PUB00151560" ]

[ "12408816", "27909983", "29236692", "31112131", "31601708", "32561715", "34519269", "36533617" ]

[ "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.", "4.4 A Resolution Cryo-EM structure of human mTOR Complex 1.", "Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.", "GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.", ...

[ 2002, 2016, 2017, 2019, 2019, 2020, 2021, 2023 ]

8

[]

0

null

[ "Eukaryota" ]

[ 5500 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 5, 8, 2, 1, 2, 6, 2, 2, 7 ]

12

true

Domain

Serine/threonine-protein kinase mTOR domain

mTOR_dom

3

IPR024586

24,586

DnaJ-like protein C11, C-terminal

DnaJ-like_C11_C

Domain

4,417

false

Chaperone DnaJ was originally characterised from Escherichia coli as a 41kDa heat shock protein. DnaJ has a modular structure consisting of a J-domain, a proximal G/F-domain, and a distal zinc finger domain, followed by less conserved C-terminal sequences. Since then, a large number of DnaJ-related proteins containing ...

[]

0

[ "PFAM" ]

[ "PF11875" ]

[ "DnaJ-like_C11_C" ]

[ 4417 ]

1

[ "REACTOME" ]

[ "R-HSA-8949613" ]

[ "REACTOME:R-HSA-8949613" ]

1

[]

0

[ "PUB00056163", "PUB00098186" ]

[ "11599562", "31550165" ]

[ "The J-domain proteins of Arabidopsis thaliana: an unexpectedly large and diverse family of chaperones.", "Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice." ]

[ 2001, 2019 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 17, 4393, 7 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 2, 1, 4, 1, 4, 3, 1, 5 ]

10

true

Domain

DnaJ-like protein C11, C-terminal

DnaJ-like_C11_C

3