LiteFold/InterPro · Datasets at Hugging Face

IPR024587

24,587

Potassium channel, voltage dependent, Kv4, C-terminal

K_chnl_volt-dep_Kv4_C

Domain

2,962

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[]

0

[ "PFAM" ]

[ "PF11879" ]

[ "DUF3399" ]

[ 2962 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1296072", "R-BTA-5576894", "R-DME-1296072", "R-DME-5576894", "R-HSA-1296072", "R-HSA-5576894", "R-MMU-1296072", "R-MMU-5576894", "R-RNO-1296072", "R-RNO-5576894" ]

[ "REACTOME:R-BTA-1296072", "REACTOME:R-BTA-5576894", "REACTOME:R-DME-1296072", "REACTOME:R-DME-5576894", "REACTOME:R-HSA-1296072", "REACTOME:R-HSA-5576894", "REACTOME:R-MMU-1296072", "REACTOME:R-MMU-5576894", "REACTOME:R-RNO-1296072", "REACTOME:R-RNO-5576894" ]

10

[ "7e83", "7e84", "7e8e", "7e8h", "7f0j", "7f3f", "7uk5", "7ukc", "7ukd", "7uke", "7ukf", "7ukg", "7ukh", "7w3y", "7w6n", "7w6s", "7w6t" ]

17

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00008322", "PUB00009378", "PUB00009391", "PUB00036046" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "9305895", "11178249", "10712896", "15269337" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1997, 2000, 2000, 2004 ]

10

[]

0

null

[ "Eumetazoa" ]

[ 2962 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 2, 7, 6, 11 ]

6

true

Domain

Potassium channel, voltage dependent, Kv4, C-terminal

K_chnl_volt-dep_Kv4_C

9

IPR024588

24,588

Inner membrane protein YejM, N-terminal

YejM_N

Domain

3,346

false

This entry represents an uncharacterised domain found in the N-terminal of inner membrane protein YejM from Gammaproteobacteria.

[]

0

[ "PFAM" ]

[ "PF11893" ]

[ "DUF3413" ]

[ 3346 ]

1

[]

0

[ "5i5d", "5i5f", "5i5h", "6v8q", "6xlp", "7t6d" ]

6

[]

0

[]

0

null

[ "Bacteria", "Methanorbis furvi", "Opisthokonta", "metagenomes" ]

[ 3325, 1, 3, 17 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Inner membrane protein YejM, N-terminal

YejM_N

6

IPR024589

24,589

Fungal ligninase, C-terminal

Ligninase_C

Domain

1,482

false

Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Peroxidases are found in bacteria, fungi, plants and animals. Fungal ligninases are extracellular haem enzymes involved in the degradation of lignin. They include lignin peroxidases (...

[]

0

[ "PFAM" ]

[ "PF11895" ]

[ "Peroxidase_ext" ]

[ 1482 ]

1

[ "EC" ]

[ "1.11.1" ]

[ "EC:1.11.1" ]

1

[ "1arp", "1aru", "1arv", "1arw", "1arx", "1ary", "1b80", "1b82", "1b85", "1c8i", "1ck6", "1gza", "1gzb", "1h3j", "1hsr", "1lga", "1llp", "1ly8", "1ly9", "1lyc", "1lyk", "1mn1", "1mn2", "1mnp", "1qpa", "1yyd", "1yyg", "1yzp", "1yzr", "2boq", "2e39", "2e3a"...

76

[ "PUB00001743", "PUB00002822", "PUB00002886", "PUB00003315", "PUB00005246", "PUB00028246" ]

[ "8167033", "8440725", "7806497", "8289254", "7922023", "10187820" ]

[ "Physiology and molecular biology of the lignin peroxidases of Phanerochaete chrysosporium.", "Crystallographic refinement of lignin peroxidase at 2 A.", "The crystal structure of manganese peroxidase from Phanerochaete chrysosporium at 2.06-A resolution.", "Crystal structure of the fungal peroxidase from Art...

[ 1994, 1993, 1994, 1994, 1994, 1999 ]

6

[]

0

null

[ "Dikarya" ]

[ 1482 ]

1

[]

0

true

Domain

Fungal ligninase, C-terminal

Ligninase_C

6

IPR024590

24,590

RNA helicase HrpA, C-terminal

HrpA_C

Domain

12,592

false

This entry represents the uncharacterised C-terminal domain of HrpA.

[]

0

[ "PFAM" ]

[ "PF11898" ]

[ "DUF3418" ]

[ 12592 ]

1

[]

0

[ "6zww", "6zwx", "7akp", "8po6", "8po7", "8po8", "9gft", "9ggr" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12461, 19, 112 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RNA helicase HrpA, C-terminal

HrpA_C

8

IPR024593

24,593

Domain of unknown function DUF3444

DUF3444

Domain

6,269

false

This entry represents an uncharacterised domain. This domain is found in DnaJ, cytosine-specific methyltransferases, and members from the zinc finger, C3HC4 type family.

[]

0

[ "PFAM" ]

[ "PF11926" ]

[ "DUF3444" ]

[ 6269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viridiplantae" ]

[ 6269 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 102, 38, 36 ]

3

true

Domain

Domain of unknown function DUF3444

DUF3444

2

IPR024596

24,596

DNA-directed RNA polymerase subunit beta/EpuA

RNApol_su_b/EpuA

Family

2,030

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[]

0

[ "PFAM" ]

[ "PF11772" ]

[ "EpuA" ]

[ 2030 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00033173" ]

[ "3052291", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 1999 ]

2

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 2029, 1 ]

2

[]

0

true

Family

DNA-directed RNA polymerase subunit beta/EpuA

RNApol_su_b/EpuA

7

IPR024598

24,598

Splicing factor SF3a60 /Prp9 subunit, C-terminal

SF3a60/Prp9_C

Domain

4,694

false

The mature U2 snRNP (small nuclear ribonucleoprotein particle) relies on the spliceosome assembly for its function, which involves the Splicing factor 3a (SF3a), an evolutionary eukaryotic conserved heterotrimeric complex, essential for pre-mRNA splicing [ ]. This complex includes three subunits: SF3a60, SF3a66 and SF3...

[ "GO:0003723", "GO:0000398", "GO:0005681" ]

[ "RNA binding", "mRNA splicing, via spliceosome", "spliceosomal complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF11931" ]

[ "SF3a60_Prp9_C" ]

[ 4694 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[ "5nrl", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6ff7", "6g90", "6qx9", "6y50", "6y53", "6y5q", "7abg", "7abh", "7abi", "7dco", "7evo", "7onb", "7oqb", "7oqe", "7q3l", "7q4o", "7q4p", "7qtt", "7vpx", "8ch6", "8h6e", "8h6j", "8h6k", "8h6l"...

46

[ "PUB00059480", "PUB00094506" ]

[ "22314233", "29360106" ]

[ "Structure and assembly of the SF3a splicing factor complex of U2 snRNP.", "Structure of the human activated spliceosome in three conformational states." ]

[ 2012, 2018 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4694 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 6, 2, 1, 3, 4, 1, 1, 7 ]

12

true

Domain

Splicing factor SF3a60 /Prp9 subunit, C-terminal

SF3a60/Prp9_C

2

IPR024599

24,599

Retinoblastoma-associated protein, N-terminal

RB_N

Domain

5,889

false

This domain is found in N-terminal of the retinoblastoma-associated protein. It is found in association with and . This domain is typically between 124 to 150 amino acids in length and has a single completely conserved residue W that may be functionally important.

[]

0

[ "PFAM", "SMART" ]

[ "PF11934", "SM01367" ]

[ "DUF3452", "DUF3452" ]

[ 5712, 5755 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1538133", "R-CEL-2173796", "R-CEL-69231", "R-DDI-113501", "R-DDI-1538133", "R-DDI-174178", "R-DDI-2299718", "R-DDI-69231", "R-DME-1538133", "R-DME-2173796", "R-DME-69231", "R-HSA-113501", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-174178", "R-HSA-2173796", "R-...

[ "REACTOME:R-CEL-1538133", "REACTOME:R-CEL-2173796", "REACTOME:R-CEL-69231", "REACTOME:R-DDI-113501", "REACTOME:R-DDI-1538133", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-2299718", "REACTOME:R-DDI-69231", "REACTOME:R-DME-1538133", "REACTOME:R-DME-2173796", "REACTOME:R-DME-69231", "REACTOME:R-HSA-...

56

[ "2qdj", "4elj" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5889 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 7, 3, 14, 12, 2, 12, 51 ]

9

true

Domain

Retinoblastoma-associated protein, N-terminal

RB_N

9

IPR024600

24,600

Notch, C-terminal

Notch_C

Domain

4,390

false

This domain can be found at the C terminus of notch and notch-related proteins.

[]

0

[ "SMART" ]

[ "SM01334" ]

[ "DUF3454" ]

[ 4390 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1912399", "R-HSA-1912408", "R-HSA-1912420", "R-HSA-210744", "R-HSA-2122947", "R-HSA-2122948", "R-HSA-2197563", "R-HSA-2644606", "R-HSA-2644607", "R-HSA-2660826", "R-HSA-2691232", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-350054", "R-HSA-5083630", "R-HSA-8941856", "R-HSA-9013507...

[ "REACTOME:R-HSA-1912399", "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-1912420", "REACTOME:R-HSA-210744", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-2197563", "REACTOME:R-HSA-2644606", "REACTOME:R-HSA-2644607", "REACTOME:R-HSA-2660826", "REACTOME:R-HSA-2691232", "REACTOME...

41

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 4390 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 13, 10, 5, 12 ]

5

true

Domain

Notch, C-terminal

Notch_C

9

IPR024601

24,601

Peptidase M1, alanyl aminopeptidase, C-terminal

Peptidase_M1_pepN_C

Domain

11,300

false

This domain, which contains a conserved FSAPV sequence motif, is found in the C-terminal of alanyl aminopeptidases that belong to MEROPS peptidase family M1 (aminopeptidase N, clan MA). The M1 family of zinc metallopeptidases contains a number of distinct, well-separated clades of proteins with aminopeptidase activity....

[]

0

[ "PFAM" ]

[ "PF17432" ]

[ "DUF3458_C" ]

[ 11300 ]

1

[]

0

[ "2dq6", "2dqm", "2gtq", "2hpo", "2hpt", "2zxg", "3b2p", "3b2x", "3b34", "3b37", "3b3b", "3ebg", "3ebh", "3ebi", "3ked", "3puu", "3q43", "3q44", "3qjx", "3t8v", "4j3b", "4k5l", "4k5m", "4k5n", "4k5o", "4k5p", "4pu2", "4pvb", "4pw4", "4q4e", "4q4i", "4qhp"...

116

[ "PUB00003579", "PUB00017063", "PUB00017064" ]

[ "7674922", "15109723", "14663077" ]

[ "Evolutionary families of metallopeptidases.", "Actinobacillus pleuropneumoniae metalloprotease: cloning and in vivo expression.", "PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress." ]

[ 1995, 2004, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Yasminevirus sp. GU-2018", "unclassified sequences" ]

[ 97, 9483, 1603, 1, 116 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 1, 2, 13 ]

4

true

Domain

Peptidase M1, alanyl aminopeptidase, C-terminal

Peptidase_M1_pepN_C

6

IPR024603

24,603

COG complex component, COG2, C-terminal

COG_complex_COG2_C

Domain

3,696

false

The COG complex comprises eight proteins (COG1-8) and plays critical roles in Golgi structure and function. It is necessary for retrograde trafficking in the Golgi apparatus and for protein glycosylation [ , ]. COG complex, together with exocyst, Golgi-associated retrograde protein (GARP) and Dsl1 complexes, is a membe...

[]

0

[ "PFAM" ]

[ "PF12022" ]

[ "COG2_C" ]

[ 3696 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6807878", "R-CEL-6811438", "R-DDI-6807878", "R-DDI-6811438", "R-DME-6807878", "R-DME-6811438", "R-DME-6811440", "R-HSA-6807878", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-6807878", "R-MMU-6811438", "R-MMU-6811440" ]

[ "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811438", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811438", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811438", "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6807878", "REACTOM...

13

[]

0

[ "PUB00012274", "PUB00097774", "PUB00100047" ]

[ "11980916", "25541219", "34061181" ]

[ "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.", "Novel coiled-coil proteins regulate exocyst association with cortical microtubules in xylem cells via the conserved oligomeric golgi-complex 2 protein.", "Homology and Modular Evo...

[ 2002, 2015, 2021 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3696 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 1, 5, 4, 2, 3, 19 ]

9

true

Domain

COG complex component, COG2, C-terminal

COG_complex_COG2_C

5

IPR024604

24,604

Serine/threonine-protein kinase haspin, C-terminal

GSG2_C

Domain

3,466

false

This domain may be a potential Haspin-related leucine-zipper. A leucine zipper was proposed to be present towards the C-terminal of human Haspin, (upstream of the current family) [ ]; however, as this domain would appear to span several helices and be largely within a loop structure [ ], the actual zipper might be furt...

[]

0

[ "SMART" ]

[ "SM01331" ]

[ "DUF3635" ]

[ 3466 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-SCE-9020702", "R-SPO-9020702" ]

[ "EC:2.7.11.1", "REACTOME:R-SCE-9020702", "REACTOME:R-SPO-9020702" ]

3

[ "2vuw", "2wb8", "3dlz", "3e7v", "3f2n", "3fmd", "3iq7", "4ouc", "4qtc", "5htb", "5htc", "6g34", "6g35", "6g36", "6g37", "6g38", "6g39", "6g3a", "6z56", "6z57", "6z58", "6z59", "6z5a", "6z5b", "6z5c", "6z5d", "6z5e", "7avq", "7ops", "7sqm", "8rdk", "9b2s"...

40

[ "PUB00056073", "PUB00056074" ]

[ "10358056", "12737306" ]

[ "Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.", "Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases." ]

[ 1999, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3466 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 2, 1, 3, 3, 1, 3, 2, 2, 1, 4 ]

12

true

Domain

Serine/threonine-protein kinase haspin, C-terminal

GSG2_C

2

IPR024605

24,605

NAD(P) transhydrogenase, alpha subunit, C-terminal

NADP_transhyd_a_C

Domain

17,227

false

This entry represents the C-terminal domain of NAD(P) transhydrogenase, alpha subunit.

[]

0

[ "PFAM" ]

[ "PF12769" ]

[ "PNTB_4TM" ]

[ 17227 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1.1", "R-BTA-71403", "R-HSA-71403", "R-MMU-71403" ]

[ "EC:7.1.1.1", "REACTOME:R-BTA-71403", "REACTOME:R-HSA-71403", "REACTOME:R-MMU-71403" ]

4

[ "4o93", "4o9p", "4o9t", "4o9u", "5uni", "6qti", "6que", "6s59" ]

8

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 55, 12866, 4004, 302 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 24, 1, 7, 5, 1, 4 ]

7

true

Domain

NAD(P) transhydrogenase, alpha subunit, C-terminal

NADP_transhyd_a_C

5

IPR024606

24,606

UPF0606 protein KIAA1549

KIAA1549

Family

2,899

false

This family includes KIAA1549 from human ( ) which has been implicated in pilocytic astrocytomas [ , , ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase...

[]

0

[ "PFAM" ]

[ "PF12877" ]

[ "KIAA1549" ]

[ 2899 ]

1

[ "REACTOME" ]

[ "R-HSA-6802952" ]

[ "REACTOME:R-HSA-6802952" ]

1

[]

0

[ "PUB00056166", "PUB00056167", "PUB00056168", "PUB00101492" ]

[ "18974108", "19363522", "19937730", "30120214" ]

[ "Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.", "Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.", "MAPK pathway activation and the origins o...

[ 2008, 2009, 2010, 2018 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2899 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 6, 9, 8 ]

4

true

Family

UPF0606 protein KIAA1549

KIAA1549

3

IPR024607

24,607

Sulfatase, conserved site

Sulfatase_CS

Conserved_site

69,282

false

Sulphatases are enzymes that hydrolyse various sulphate esters. The sequence of different types of sulphatases are available and have shown to be structurally related [ , , ]; these include: arylsulphatase A (ASA), a lysosomal enzyme which hydrolyses cerebroside sulphate; arylsulphatase B (ASB), which hydrolyses the su...

[]

0

[ "PROSITE", "PROSITE" ]

[ "PS00149", "PS00523" ]

[ "SULFATASE_2", "SULFATASE_1" ]

[ 41322, 52715 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.1.6", "R-BTA-1663150", "R-BTA-6798695", "R-BTA-9840310", "R-CFA-2022857", "R-CFA-6798695", "R-HSA-1663150", "R-HSA-196071", "R-HSA-2022857", "R-HSA-2024096", "R-HSA-2024101", "R-HSA-2206285", "R-HSA-2206290", "R-HSA-2206296", "R-HSA-2206305", "R-HSA-2206307", "R-HSA-432720", "R-...

[ "EC:3.1.6", "REACTOME:R-BTA-1663150", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9840310", "REACTOME:R-CFA-2022857", "REACTOME:R-CFA-6798695", "REACTOME:R-HSA-1663150", "REACTOME:R-HSA-196071", "REACTOME:R-HSA-2022857", "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-2024101", "REACTOME:R-HSA-2206285...

38

[ "1auk", "1e1z", "1e2s", "1e33", "1e3c", "1fsu", "1hdh", "1n2k", "1n2l", "1p49", "2qzu", "3ed4", "4cxk", "4cxs", "4cxu", "4cyr", "4cys", "4fdi", "4fdj", "4k38", "4mhx", "4miv", "5aj9", "5fql", "5g2v", "6fny", "6g5z", "6g60", "6hhm", "6ioz", "6prm", "6psm"...

73

[ "PUB00001466", "PUB00002603", "PUB00003733", "PUB00004716" ]

[ "8681943", "2303452", "2476654", "2122463" ]

[ "The evolutionary conservation of a novel protein modification, the conversion of cysteine to serinesemialdehyde in arylsulfatase from Volvox carteri.", "Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.", "Structure and expression of the gene encoding the peripl...

[ 1996, 1990, 1989, 1990 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Klosneuvirinae", "unclassified sequences" ]

[ 144, 40563, 27495, 3, 1077 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", ...

[ 3, 106, 15, 3, 75, 33, 2, 42, 1, 1 ]

10

true

Conserved_site

Sulfatase, conserved site

Sulfatase_CS

6

IPR024608

24,608

Smad anchor for receptor activation-like, Smad-binding domain

SARA-like_SBD

Domain

1,871

false

This entry represents the Smad-binding domain (SBD) of SARA, which is also known as Zinc finger FYVE domain-containing protein 9. This domain consists of a rigid coil, an α-helix, and a β-strand, and interacts with Smad2 [ ]. It is found C-terminal to the FYVE zinc finger domain ( ). Smad proteins mediate transforming ...

[]

0

[ "PFAM", "SMART" ]

[ "PF11409", "SM01422" ]

[ "SARA", "SARA" ]

[ 1785, 1869 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2173788", "R-HSA-2173789", "R-HSA-3304356", "R-HSA-3656532" ]

[ "REACTOME:R-HSA-2173788", "REACTOME:R-HSA-2173789", "REACTOME:R-HSA-3304356", "REACTOME:R-HSA-3656532" ]

4

[ "1dev", "1mk2" ]

2

[ "PUB00024191", "PUB00042868" ]

[ "10615055", "9865696" ]

[ "Structural basis of Smad2 recognition by the Smad anchor for receptor activation.", "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor." ]

[ 2000, 1998 ]

2

[]

0

null

[ "Bilateria" ]

[ 1871 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 2, 2, 3, 4 ]

5

true

Domain

Smad anchor for receptor activation-like, Smad-binding domain

SARA-like_SBD

6

IPR024609

24,609

Extracellular sulfatase, C-terminal

Extracellular_sulfatase_C

Domain

4,378

false

This uncharacterised domain is found in the C-terminal region of extracellular sulphatase proteins.

[]

0

[ "PFAM" ]

[ "PF12548" ]

[ "DUF3740" ]

[ 4378 ]

1

[ "EC", "EC" ]

[ "3.1.6.1", "3.1.6.14" ]

[ "EC:3.1.6.1", "EC:3.1.6.14" ]

2

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 4378 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 80, 3, 7, 4, 14 ]

5

true

Domain

Extracellular sulfatase, C-terminal

Extracellular_sulfatase_C

6

IPR024613

24,613

Huntingtin, N-terminal, HEAT repeats 2

Huntingtin_N_HEAT_rpt-2

Repeat

2,342

false

This entry represents the second set of HEAT repeats of the N-terminal domain from Huntingtin (Htt) [ ]. It is separated from the rest of the domain ( ) by an unstructured region. This repeated domain is less than 40 amino acids in length and is present in huntingtin protein (Htt). Htt is expressed in many tissues, wit...

[]

0

[ "PFAM" ]

[ "PF12372" ]

[ "Htt_N-HEAT" ]

[ 2342 ]

1

[ "REACTOME" ]

[ "R-HSA-9022692" ]

[ "REACTOME:R-HSA-9022692" ]

1

[ "6ez8", "6rmh", "6x9o", "6yej", "7dxj", "7dxk", "8vlx", "8w15", "8yae", "8yao", "9pmw", "9pn0" ]

12

[ "PUB00100583", "PUB00100584" ]

[ "29466333", "32668197" ]

[ "The cryo-electron microscopy structure of huntingtin.", "The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain." ]

[ 2018, 2020 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2342 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 2, 9, 2, 5 ]

5

true

Repeat

Huntingtin, N-terminal, HEAT repeats 2

Huntingtin_N_HEAT_rpt-2

9

IPR024615

24,615

CRISPR-associated protein Cmr2, N-terminal

CRISPR-assoc_Cmr2_N

Domain

1,114

false

This domain family is typically between 101 and 138 amino acids in length and is found in subunit Crm2 of the CRISPR RNA-Cas protein complex (Cmr complex) [ ].

[]

0

[ "PFAM" ]

[ "PF12469" ]

[ "Cmr2_N" ]

[ 1114 ]

1

[]

0

[ "3ung", "3ur3", "3w2v", "3w2w", "3x1l", "4doz", "4h4k", "4w8y", "6s6b", "6s8b", "6s8e", "6s91", "6sh8", "6shb", "6sic", "9arw" ]

16

[ "PUB00088224" ]

[ "25280103" ]

[ "Structural model of a CRISPR RNA-silencing complex reveals the RNA-target cleavage activity in Cmr4." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 123, 978, 13 ]

3

[]

0

true

Domain

CRISPR-associated protein Cmr2, N-terminal

CRISPR-assoc_Cmr2_N

5

IPR024616

24,616

Pherophorin

Domain

1,399

false

This domain is found in a family of plant proteins that are frequently annotated as pherophorin [ , , ]. The domain often occurs twice and is typically between 147 and 160 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF12499" ]

[ "DUF3707" ]

[ 1399 ]

1

[]

0

[]

0

[ "PUB00056075", "PUB00056076", "PUB00056077" ]

[ "2839374", "16453787", "8458341" ]

[ "The sexual inducer of Volvox carteri. Primary structure deduced from cDNA sequence.", "The sexual inducer of Volvox carteri: purification, chemical characterization and identification of its gene.", "How a sex pheromone might act at a concentration below 10(-16) M." ]

[ 1988, 1987, 1993 ]

3

[]

0

null

[ "CS clade", "viral metagenome" ]

[ 1398, 1 ]

2

[]

0

true

Domain

Pherophorin

7

IPR024617

24,617

Domain of unknown function DUF3870

DUF3870

Domain

1,371

false

This domain is found in the C-terminal region of the putative pore-forming toxin YP_001301288.1 from Bacteroides vulgatus ATCC3 [ , ], suggesting that the domain may have a lytic function.

[]

0

[ "PFAM" ]

[ "PF12986" ]

[ "DUF3870" ]

[ 1371 ]

1

[]

0

[]

0

[ "PUB00031944", "PUB00032169" ]

[ "15258571", "15687495" ]

[ "Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.", "Structural analysis of the Laetiporus sulphureus hemolytic pore-forming lectin in complex with sugars." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1357, 14 ]

2

[]

0

true

Domain

Domain of unknown function DUF3870

DUF3870

6

IPR024618

24,618

Domain of unknown function DUF3857

DUF3857

Domain

7,484

false

This domain is based on the first domain of the PDB structure 3KD4 (residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase, despite lack of any significant sequence similarity. The domain is N-terminal to a transglutaminase domain, which is found in many proteins known ...

[]

0

[ "PFAM" ]

[ "PF12969" ]

[ "DUF3857" ]

[ 7484 ]

1

[]

0

[ "3kd4" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7406, 11, 67 ]

3

[]

0

true

Domain

Domain of unknown function DUF3857

DUF3857

8

IPR024619

24,619

Protein of unknown function DUF3860

DUF3860

Family

27

false

This entry includes uncharacterised archaeal proteins. These proteins contain a winged helix DNA-binding domain fold.

[]

0

[ "PFAM" ]

[ "PF12976" ]

[ "DUF3860" ]

[ 27 ]

1

[]

0

[ "2od5" ]

1

[]

0

[]

0

null

[ "Methanobacteriati", "unclassified sequences" ]

[ 17, 10 ]

2

[]

0

true

Family

Protein of unknown function DUF3860

DUF3860

2

IPR024620

24,620

Domain of unknown function DUF3869

DUF3869

Domain

114

false

This domain of unknown fuction is found at the N-terminal of putative pore-forming toxin YP_001301288.1 from Bacteroides vulgatus ATCC 8482 ( , ), which shows weak but consistent remote homology with adhesive families such as immunoglobulins and cadherins, suggesting it might form an attachment module.

[]

0

[ "PFAM" ]

[ "PF12985" ]

[ "DUF3869" ]

[ 114 ]

1

[]

0

[ "3g3l", "3kog" ]

2

[]

0

[]

0

null

[ "Bacteria", "Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)", "bioreactor metagenome" ]

[ 112, 1, 1 ]

3

[]

0

true

Domain

Domain of unknown function DUF3869

DUF3869

7

IPR024621

24,621

Inner membrane mitoribosome receptor Mba1, mitochondrial

Mba1

Family

711

false

This entry represents Mba1 from budding yeasts and its homologues.

[ "GO:0032979", "GO:0005743" ]

[ "protein insertion into mitochondrial inner membrane from matrix", "mitochondrial inner membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07961" ]

[ "MBA1" ]

[ 711 ]

1

[]

0

[]

0

[ "PUB00016453", "PUB00016554", "PUB00042558" ]

[ "11381092", "8690083", "16601683" ]

[ "Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae.", "MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain.", "Mba1, a membrane-associated ribosome receptor in mitochondria." ]

[ 2001, 1996, 2006 ]

3

[]

[ "IPR012483" ]

0

1

0

[ "Eukaryota" ]

[ 711 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Inner membrane mitoribosome receptor Mba1, mitochondrial

Mba1

3

IPR024623

24,623

Uncharacterised protein family YtxH

YtxH

Family

9,239

false

This family of uncharacterised proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved.

[]

0

[ "PFAM" ]

[ "PF12732" ]

[ "YtxH" ]

[ 9239 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9131, 13, 95 ]

3

[]

0

true

Family

Uncharacterised protein family YtxH

YtxH

7

IPR024624

24,624

Pyridoxamine 5'-phosphate oxidase, Alr4036 family, FMN-binding domain

Pyridox_Oxase_Alr4036_FMN-bd

Domain

3,918

false

This entry represents Pyridoxamine 5'-phosphate oxidase 2 from Arabidopsis thaliana and its homologues from yeast, which catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP) [ ].

[ "GO:0010181" ]

[ "FMN binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12766" ]

[ "Pyridox_oxase_2" ]

[ 3918 ]

1

[]

0

[ "2i51", "2ou5" ]

2

[ "PUB00073573" ]

[ "17224143" ]

[ "Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1422, 2481, 15 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 3, 1, 1, 5 ]

6

true

Domain

Pyridoxamine 5'-phosphate oxidase, Alr4036 family, FMN-binding domain

Pyridox_Oxase_Alr4036_FMN-bd

8

IPR024626

24,626

Kri1-like, C-terminal

Kri1-like_C

Domain

4,155

false

The yeast member of the Kri1-like family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus [ ]. This entry represents the C-terminal domain of this protein family.

[]

0

[ "PFAM" ]

[ "PF12936" ]

[ "Kri1_C" ]

[ 4155 ]

1

[]

0

[ "9g25", "9g28" ]

2

[ "PUB00010176" ]

[ "11027267" ]

[ "Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4154, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 1, 4, 3, 1, 2, 2, 1, 1, 2 ]

12

true

Domain

Kri1-like, C-terminal

Kri1-like_C

7

IPR024627

24,627

V(D)J recombination-activating protein 1

RAG1

Family

45,010

false

The development of B and T cells depends on the rearrangement of variable (V), diversity (D), and joining (J) gene segments to produce mature Ig and T cell receptor coding regions. This rearrangement process, known as V(D)J recombination is initiated by a complex consisting of multi-domain proteins RAG1 and RAG2. The R...

[ "GO:0004519", "GO:0043565", "GO:0061630", "GO:0033151" ]

[ "endonuclease activity", "sequence-specific DNA binding", "ubiquitin protein ligase activity", "V(D)J recombination" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PANTHER" ]

[ "PTHR11539" ]

[ "" ]

[ 45010 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "1rmd", "3gna", "3gnb", "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep"...

45

[ "PUB00030727", "PUB00056079", "PUB00077748", "PUB00077749", "PUB00077750", "PUB00077751" ]

[ "9228952", "19621044", "14671314", "22796426", "19118899", "21256161" ]

[ "Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.", "RAG: a recombinase diversified.", "Autoubiquitylation of the V(D)J recombinase protein RAG1.", "Characterization of RAG1 and IgM (mu chain) marking development of the immune sys...

[ 1997, 2009, 2003, 2012, 2009, 2011 ]

6

[]

0

null

[ "Metazoa" ]

[ 45010 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 8, 7 ]

4

true

Family

V(D)J recombination-activating protein 1

RAG1

9

IPR024628

24,628

Sulphotransferase Stf0, domain

Sulfotransferase_Stf0_dom

Domain

1,200

false

Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel β-sheet flanked by α-helices [ ].

[]

0

[ "PFAM" ]

[ "PF09037" ]

[ "Sulphotransf" ]

[ 1200 ]

1

[ "EC", "METACYC" ]

[ "2.8.2.37", "PWY-7746" ]

[ "EC:2.8.2.37", "METACYC:PWY-7746" ]

2

[ "1tex" ]

1

[ "PUB00031430" ]

[ "15258569" ]

[ "Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1167, 10, 23 ]

3

[]

0

true

Domain

Sulphotransferase Stf0, domain

Sulfotransferase_Stf0_dom

9

IPR024629

24,629

Large ribosomal subunit protein mL67

Ribosomal_mL67

Family

1,289

false

Saccharomyces cerevisiae Mhr1 (also known as Large ribosomal subunit protein mL67) promotes homologous DNA pairing and functions as a mitochondrial recombinase that mediates the predominant form of mtDNA replication and acts in mtDNA segregation and the repair of mtDNA double-stranded breaks (DSBs) [ , ]. This entry al...

[ "GO:0000150", "GO:0003697", "GO:0006310", "GO:0032543" ]

[ "DNA strand exchange activity", "single-stranded DNA binding", "DNA recombination", "mitochondrial translation" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PFAM", "PANTHER" ]

[ "PF12829", "PTHR28184" ]

[ "Mhr1", "" ]

[ 1275, 1239 ]

2

[]

0

[ "3j6b", "5mrc", "5mre", "5mrf", "6ywe", "6yws", "6ywv", "6ywx", "6ywy" ]

9

[ "PUB00044377", "PUB00056132", "PUB00095590" ]

[ "16451194", "12198175", "30931958" ]

[ "Identification and comparative analysis of the large subunit mitochondrial ribosomal proteins of Neurospora crassa.", "Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA.", "Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombi...

[ 2006, 2002, 2019 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1289 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Large ribosomal subunit protein mL67

Ribosomal_mL67

1

IPR024630

24,630

Stc1 domain

Stc1

Domain

1,173

false

The domain contains 8 conserved cysteines that may bind to zinc. In S. pombe, proteins containing the domain act as protein linkers, which link the chromatin modifying CLRC complex to RNAi by tethering it to the RITS complex. This domain has a slightly different arrangement of its CxxC pairs from the LIM domain, hence ...

[]

0

[ "PFAM" ]

[ "PF12898" ]

[ "Stc1" ]

[ 1173 ]

1

[]

0

[ "2luy" ]

1

[ "PUB00056081" ]

[ "20211136" ]

[ "Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity." ]

[ 2010 ]

1

[]

0

null

[ "Bacillati", "Eukaryota", "Sylvanvirus sp.", "viral metagenome" ]

[ 3, 1168, 1, 1 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

Stc1 domain

Stc1

8

IPR024631

24,631

Transcription factor p53, C-terminal, Drosophila

p53_C_Drosophila

Domain

48

false

The p53 tumour suppressor [ , , , , ] is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating non-transformed cells, but it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 ...

[]

0

[ "PFAM" ]

[ "PF11619" ]

[ "P53_C" ]

[ 48 ]

1

[]

0

[ "2rp4" ]

1

[ "PUB00000596", "PUB00001893", "PUB00002729", "PUB00003921", "PUB00004096", "PUB00004490", "PUB00005186", "PUB00049456" ]

[ "2142001", "2137806", "1639769", "7796267", "2046748", "2142762", "8023159", "17581633" ]

[ "Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products.", "p53: oncogene or anti-oncogene?", "The p53 tumor suppressor protein, a modulator of cell proliferation.", "Refined solution structure of the oligomerization domain of the tumour suppressor p53.", "The p53 tumour supp...

[ 1990, 1990, 1992, 1995, 1991, 1990, 1994, 2007 ]

8

[]

0

null

[ "Drosophilinae" ]

[ 48 ]

1

[ "Drosophila melanogaster" ]

[ 6 ]

1

true

Domain

Transcription factor p53, C-terminal, Drosophila

p53_C_Drosophila

9

IPR024632

24,632

Phospholipase D, C-terminal

PLipase_D_C

Domain

6,566

false

Phospholipase D (PLD) catalyses the hydrolysis of the phosphodiester bond of glycerophospholipids to generate phosphatidic acid and a free head group. Phospholipase D activities have been detected in simple to complex organisms from viruses and bacteria to yeast, plants, and mammals [ ]. In higher organisms, PLD specif...

[]

0

[ "PFAM" ]

[ "PF12357" ]

[ "PLD_C" ]

[ 6566 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.1.4.4", "PWY-3561", "PWY-7039" ]

[ "EC:3.1.4.4", "METACYC:PWY-3561", "METACYC:PWY-7039" ]

3

[ "6kz8", "6kz9" ]

2

[ "PUB00034910" ]

[ "15052340" ]

[ "Phospholipase D." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6566 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 49, 44, 69 ]

3

true

Domain

Phospholipase D, C-terminal

PLipase_D_C

6

IPR024633

24,633

DnaA N-terminal domain

DnaA_N_dom

Domain

19,874

false

This entry represents the N-terminal domain of bacterial DnaA proteins [ , , ], which play an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of rep...

[]

0

[ "PFAM" ]

[ "PF11638" ]

[ "DnaA_N" ]

[ 19874 ]

1

[]

0

[ "2e0g", "2z4r", "2z4s", "4tps", "8btg" ]

5

[ "PUB00000665", "PUB00003815", "PUB00005517", "PUB00047979" ]

[ "8110826", "1779750", "2558436", "17680349" ]

[ "The initiator protein DnaA: evolution, properties and function.", "Structure and function of DnaA and the DnaA-box in eubacteria: evolutionary relationships of bacterial replication origins.", "The E. coli dnaA initiation protein: a protein for all seasons.", "NMR structure of the N-terminal domain of the re...

[ 1994, 1991, 1989, 2007 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 19405, 35, 2, 5, 427 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DnaA N-terminal domain

DnaA_N_dom

9

IPR024634

24,634

Internalin, N-terminal

Internalin_N

Domain

1,255

false

This entry represents the N-terminal domain of internalin, the cap domain of the protein. This domain is found in bacteria, and is approximately 60 amino acids in length. There are two completely conserved residues (I and F) that may be functionally important. Internalin mediates bacterial adhesion and invasion of epit...

[]

0

[ "PFAM" ]

[ "PF12354" ]

[ "Internalin_N" ]

[ 1255 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8875360", "R-HSA-8876493" ]

[ "REACTOME:R-HSA-8875360", "REACTOME:R-HSA-8876493" ]

2

[ "1d0b", "1h6t", "1h6u", "1m9s", "1o6s", "1o6t", "1o6v", "1otm", "1otn", "1oto", "1xeu", "2omt", "2omu", "2omv", "2omw", "2omx", "2omy", "2omz", "2uzx", "2uzy", "2wqu", "2wqv", "2wqw", "2wqx", "2y5q", "3rfj", "3rfs", "4aw4", "4cc4", "4fho", "4fmz", "4j4l"...

62

[ "PUB00016485" ]

[ "12526809" ]

[ "Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin." ]

[ 2002 ]

1

[]

0

null

[ "Bacillati" ]

[ 1255 ]

1

[]

0

true

Domain

Internalin, N-terminal

Internalin_N

2

IPR024635

24,635

Gonadotropin hormone receptor, transmembrane domain

GnHR_TM

Domain

859

false

This domain represents the transmembrane region of follicular stimulating hormone and luteinizing hormone receptors- the two major gonadotropin hormone receptors. This domain is found in eukaryotes, and is approximately 70 amino acids in length. There are two completely conserved C residues that may be functionally imp...

[]

0

[ "PFAM" ]

[ "PF12369" ]

[ "GnHR_trans" ]

[ 859 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-375281", "R-HSA-418555", "R-MMU-375281", "R-MMU-418555", "R-RNO-375281" ]

[ "REACTOME:R-HSA-375281", "REACTOME:R-HSA-418555", "REACTOME:R-MMU-375281", "REACTOME:R-MMU-418555", "REACTOME:R-RNO-375281" ]

5

[ "4ay9", "4mqw", "8i2g", "8i2h" ]

4

[ "PUB00056083" ]

[ "18248232" ]

[ "Gonadotropin hormone and receptor sequences from model teleost species." ]

[ 2004 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 859 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 2 ]

3

true

Domain

Gonadotropin hormone receptor, transmembrane domain

GnHR_TM

7

IPR024636

24,636

Histone lysine methyltransferase SET associated

SET_assoc

Domain

1,435

false

The SET domain is a protein-protein interaction domain found in protein lysine methyltransferase enzymes. This entry represents a domain of unknown function which is associated with the SET domain and found in histone lysine methyltransferases [ ].

[]

0

[ "PFAM" ]

[ "PF11767" ]

[ "SET_assoc" ]

[ 1435 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.354", "R-SCE-3214841", "R-SCE-9772755", "R-SPO-3214841", "R-SPO-9772755" ]

[ "EC:2.1.1.354", "REACTOME:R-SCE-3214841", "REACTOME:R-SCE-9772755", "REACTOME:R-SPO-3214841", "REACTOME:R-SPO-9772755" ]

5

[]

0

[ "PUB00010205" ]

[ "12389037" ]

[ "Structure of the SET domain histone lysine methyltransferase Clr4." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1435 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Histone lysine methyltransferase SET associated

SET_assoc

2

IPR024637

24,637

CTD kinase subunit gamma Ctk3, C-terminal

Ctk3_C

Domain

1,683

false

The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed throug...

[]

0

[ "PFAM" ]

[ "PF12350" ]

[ "CTK3_C" ]

[ 1683 ]

1

[]

0

[ "7jv7" ]

1

[ "PUB00053283" ]

[ "11118453" ]

[ "Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1683 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

CTD kinase subunit gamma Ctk3, C-terminal

Ctk3_C

4

IPR024638

24,638

CTD kinase subunit gamma Ctk3, N-terminal

Ctk3_N

Domain

1,668

false

The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed throug...

[]

0

[ "PFAM" ]

[ "PF12243" ]

[ "CTK3" ]

[ 1668 ]

1

[]

0

[ "5ce7" ]

1

[ "PUB00053283", "PUB00053284" ]

[ "11118453", "16721054" ]

[ "Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits.", "Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb." ]

[ 2001, 2006 ]

2

[ "IPR006569" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1668 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

CTD kinase subunit gamma Ctk3, N-terminal

Ctk3_N

5

IPR024639

24,639

DNA polymerase epsilon subunit B, N-terminal

DNA_pol_e_bsu_N

Domain

1,841

false

This domain is found in the N-terminal of DNA polymerase epsilon subunit B proteins. It contains a single completely conserved phenylalanine residue that may be functionally important. It forms a primarily α helical structure in which four helices are arranged in two hairpins with connecting loops containing β strands ...

[]

0

[ "PFAM" ]

[ "PF12213" ]

[ "Dpoe2NT" ]

[ 1841 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-110314", "R-CEL-5651801", "R-CEL-5656169", "R-CEL-5696397", "R-CEL-5696400", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-68952", "R-CEL-68962", "R-DME-110314", "R-DME-5651801", "R-DME-5656169", "R-DME-5696400", "R-DME-6782135", "R-DME-68952", "R-DME-68962", "R-GGA-110314", "R-G...

[ "REACTOME:R-CEL-110314", "REACTOME:R-CEL-5651801", "REACTOME:R-CEL-5656169", "REACTOME:R-CEL-5696397", "REACTOME:R-CEL-5696400", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-68952", "REACTOME:R-CEL-68962", "REACTOME:R-DME-110314", "REACTOME:R-DME-5651801", "REACTOME:R-DM...

44

[ "2v6z", "5vbn", "7pfo", "7plo" ]

4

[ "PUB00049604" ]

[ "18676977" ]

[ "The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1841 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 1, 4, 1, 5, 3, 1, 3, 4 ]

8

true

Domain

DNA polymerase epsilon subunit B, N-terminal

DNA_pol_e_bsu_N

5

IPR024640

24,640

Toxin-antitoxin type 1 system, toxin component

Toxin-antitoxin_type_1_toxin

Family

143

false

This family is the toxin of a type 1 toxin-antitoxin system which is found in a relatively widespread range of bacterial species. The species distribution suggests frequent horizontal gene transfer. In a type 1 system, as characterised for the plasmid-encoded E coli hok/sok system, the toxin-encoding stable mRNA encode...

[]

0

[ "PFAM" ]

[ "PF12703" ]

[ "ptaRNA1_toxin" ]

[ 143 ]

1

[]

0

[]

0

[ "PUB00056084" ]

[ "20220307" ]

[ "A novel family of plasmid-transferred anti-sense ncRNAs." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Dorcoceras hygrometricum", "bioreactor metagenome" ]

[ 141, 1, 1 ]

3

[]

0

true

Family

Toxin-antitoxin type 1 system, toxin component

Toxin-antitoxin_type_1_toxin

4

IPR024641

24,641

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain

HRS_helical

Domain

2,489

false

This domain comprises the helical region of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS). It is approximately 100 amino acids in length. Hrs, together with signal transducing adaptor molecule (STAM), forms the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degra...

[]

0

[ "PFAM", "CDD" ]

[ "PF12210", "cd21387" ]

[ "Hrs_helical", "GAT_Hrs" ]

[ 2489, 2224 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-182971", "R-BTA-432720", "R-BTA-5689880", "R-BTA-6807004", "R-BTA-8856825", "R-BTA-8856828", "R-BTA-9013420", "R-BTA-917729", "R-BTA-9706019", "R-DME-182971", "R-DME-432720", "R-DME-5689880", "R-DME-8856825", "R-DME-8856828", "R-DME-9013420", "R-DME-917729", "R-DME-9706019", ...

[ "REACTOME:R-BTA-182971", "REACTOME:R-BTA-432720", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-6807004", "REACTOME:R-BTA-8856825", "REACTOME:R-BTA-8856828", "REACTOME:R-BTA-9013420", "REACTOME:R-BTA-917729", "REACTOME:R-BTA-9706019", "REACTOME:R-DME-182971", "REACTOME:R-DME-432720", "REACTOME:R-D...

47

[ "3f1i" ]

1

[ "PUB00051849" ]

[ "19278655" ]

[ "Hybrid structural model of the complete human ESCRT-0 complex." ]

[ 2009 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 2489 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 8, 3, 25, 4, 7 ]

6

true

Domain

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain

HRS_helical

6

IPR024642

24,642

SUZ-C domain

SUZ-C

Domain

7,093

false

The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins [ ]. It is always found at the C terminus of the protein and appears to be required for localization of the protein to specific subcellular structures. The domain was first characterised in the C.elegans protein SZY-20, a ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF12901", "PS51938" ]

[ "SUZ-C", "SUZ_C" ]

[ 5443, 6768 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-191859", "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]

[ "REACTOME:R-BTA-191859", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]

4

[]

0

[ "PUB00056085", "PUB00097541" ]

[ "19081077", "27689799" ]

[ "The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.", "ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics." ]

[ 2008, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 7093 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 40, 3, 17, 19, 1, 18 ]

6

true

Domain

SUZ-C domain

SUZ-C

3

IPR024643

24,643

Histone deacetylase, glutamine rich N-terminal domain

Hist_deacetylase_Gln_rich_N

Domain

5,889

false

This domain is found in eukaryotic histone deacetylases, and is approximately 90 amino acids in length. The domain forms an α helix, which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions that are thought to be involved in reversible assembly and disassembly of pr...

[]

0

[ "PFAM" ]

[ "PF12203" ]

[ "HDAC4_Gln" ]

[ 5889 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1.98", "R-GGA-350054", "R-GGA-4090294", "R-GGA-4551638", "R-GGA-8951936", "R-HSA-2122947", "R-HSA-2644606", "R-HSA-2894862", "R-HSA-350054", "R-HSA-4090294", "R-HSA-4551638", "R-HSA-8941284", "R-HSA-8943724", "R-HSA-8951936", "R-MMU-350054", "R-MMU-4090294", "R-MMU-4551638", "...

[ "EC:3.5.1.98", "REACTOME:R-GGA-350054", "REACTOME:R-GGA-4090294", "REACTOME:R-GGA-4551638", "REACTOME:R-GGA-8951936", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-2644606", "REACTOME:R-HSA-2894862", "REACTOME:R-HSA-350054", "REACTOME:R-HSA-4090294", "REACTOME:R-HSA-4551638", "REACTOME:R-HSA-89412...

22

[ "2h8n", "2o94", "7xuz" ]

3

[ "PUB00041321" ]

[ "17360518" ]

[ "Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains." ]

[ 2007 ]

1

[]

0

null

[ "Bilateria" ]

[ 5889 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 25, 26, 23, 22 ]

4

true

Domain

Histone deacetylase, glutamine rich N-terminal domain

Hist_deacetylase_Gln_rich_N

7

IPR024645

24,645

Mitochondrial export protein Som1

Mitochondr_Som1

Family

1,138

false

Som1 is a component of the mitochondrial protein export system. Som1 proteins exhibit a highly conserved region and a pattern of cysteine residues [ ]. Stabilisation of Som1 occurs through an interaction between Som1 and Imp1, a peptidase required for proteolytic processing of certain proteins during their transport ac...

[ "GO:0042720" ]

[ "mitochondrial inner membrane peptidase complex" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF11093" ]

[ "Mitochondr_Som1" ]

[ 1138 ]

1

[ "GP" ]

[ "GenProp2040" ]

[ "GP:GenProp2040" ]

1

[]

0

[ "PUB00056086", "PUB00056087" ]

[ "9604886", "10821182" ]

[ "The Saccharomyces cerevisiae SOM1 gene: heterologous complementation studies, homologues in other organisms, and association of the gene product with the inner mitochondrial membrane.", "Som1, a third component of the yeast mitochondrial inner membrane peptidase complex that contains Imp1 and Imp2." ]

[ 1998, 2000 ]

2

[]

0

null

[ "Fungi" ]

[ 1138 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Mitochondrial export protein Som1

Mitochondr_Som1

9

IPR024646

24,646

Angiomotin, C-terminal

Angiomotin_C

Domain

3,813

false

This domain represents the C-terminal region of angiomotin. Angiomotin regulates the action of angiogenesis-inhibitor angiostatin [ ]. The C-terminal region of angiomotin appears to be involved in directing the protein chemotactically [ ].

[]

0

[ "PFAM" ]

[ "PF12240" ]

[ "Angiomotin_C" ]

[ 3813 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2028269", "R-CFA-2028269", "R-DRE-2028269", "R-HSA-2028269", "R-HSA-9762292", "R-MMU-2028269", "R-MMU-9762292", "R-RNO-2028269" ]

[ "REACTOME:R-BTA-2028269", "REACTOME:R-CFA-2028269", "REACTOME:R-DRE-2028269", "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-9762292", "REACTOME:R-MMU-2028269", "REACTOME:R-MMU-9762292", "REACTOME:R-RNO-2028269" ]

8

[]

0

[ "PUB00013917", "PUB00056088" ]

[ "11257124", "12902404" ]

[ "Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation.", "Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin." ]

[ 2001, 2003 ]

2

[]

0

null

[ "Metazoa", "Thermococcus camini" ]

[ 3812, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 10, 10, 12 ]

4

true

Domain

Angiomotin, C-terminal

Angiomotin_C

9

IPR024647

24,647

DNA polymerase alpha catalytic subunit, N-terminal domain

DNA_pol_a_cat_su_N

Domain

4,560

false

This entry represents the N-terminal domain of DNA polymerase alpha catalytic subunit (the DNA polymerase alpha complex is composed of four subunits). This domain is approximately 70 amino acids in length and it contains a specific labile site [ ].

[]

0

[ "PFAM" ]

[ "PF12254" ]

[ "DNA_pol_alpha_N" ]

[ 4560 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-DME-113501", "R-DME-68952", "R-DME-68962", "R-DME-69091", "R-DME-69166", "R-DME-69183", "R-HSA-113501", "R-HSA-174411", "R-HSA-174430", "R-HSA-68952", "R-HSA-68962", "R-HSA-69091", "R-HSA-69166", "R-HSA-69183", "R-HSA-69205", "R-HSA-9710421", "R-MMU-113501", "R-MMU-...

[ "EC:2.7.7.7", "REACTOME:R-DME-113501", "REACTOME:R-DME-68952", "REACTOME:R-DME-68962", "REACTOME:R-DME-69091", "REACTOME:R-DME-69166", "REACTOME:R-DME-69183", "REACTOME:R-HSA-113501", "REACTOME:R-HSA-174411", "REACTOME:R-HSA-174430", "REACTOME:R-HSA-68952", "REACTOME:R-HSA-68962", "REACTOME:...

45

[ "8b9a", "8b9b", "8b9c", "8b9d", "8d0k", "8d96", "8d9d", "8foc", "8fod", "8foe", "8foh", "8foj", "8fok", "8qj7" ]

14

[ "PUB00056089" ]

[ "2243771" ]

[ "Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus." ]

[ 1990 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4560 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 1, 1, 3, 3, 1, 2, 6, 1, 1, 3 ]

12

true

Domain

DNA polymerase alpha catalytic subunit, N-terminal domain

DNA_pol_a_cat_su_N

5

IPR024648

24,648

Transposon Tf2-1-like domain

Tf2-1-like_dom

Domain

14

false

This entry represents a domain found in Transposon Tf2-1 polyprotein from Schizosaccharomyces pombe (Tf2-1). It shows high similarity to an aspartic peptidase domain. Members of this group are specific to Schizosaccharomyces. The Tf2-1 polyprotein encodes several functional domains that act in concert during retrotrans...

[]

0

[ "PFAM" ]

[ "PF12382" ]

[ "Peptidase_A2_2" ]

[ 14 ]

1

[ "EC", "EC", "EC" ]

[ "2.7.7.49", "2.7.7.7", "3.4.23.-" ]

[ "EC:2.7.7.49", "EC:2.7.7.7", "EC:3.4.23.-" ]

3

[]

0

[ "PUB00163234", "PUB00163235", "PUB00163236", "PUB00163237" ]

[ "11003674", "12692246", "8223497", "9774697" ]

[ "Nuclear import of the retrotransposon Tf1 is governed by a nuclear localization signal that possesses a unique requirement for the FXFG nuclear pore factor Nup124p.", "A long terminal repeat-containing retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like partic...

[ 2000, 2003, 1993, 1998 ]

4

[]

0

null

[ "Schizosaccharomyces pombe" ]

[ 14 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 13 ]

1

true

Domain

Transposon Tf2-1-like domain

Tf2-1-like_dom

9

IPR024651

24,651

FAD-containing D-sorbitol dehydrogenase small subunit

FAD-SLDH_ssu

Family

1,325

false

There are two types of membrane-bound D-sorbitol dehydrogenase: PQQ-SLDH (pyrroloquinoline quinone sorbitol dehydrogenase) and FAD-SLDH (FAD-containing sorbitol dehydrogenase). FAD-SLDH is involved in oxidation of D-sorbitol to L-sorbose and consists of a large, small and cytochrome c subunits [ ]. This entry represent...

[]

0

[ "PFAM" ]

[ "PF12318" ]

[ "FAD-SLDH" ]

[ 1325 ]

1

[]

0

[ "6a2u", "7w2j", "7wsq", "8grj", "8hdd", "8jej", "8jek", "8k6j", "8k6k", "8xcm", "8xcn", "9jqa" ]

12

[ "PUB00056092" ]

[ "15973043" ]

[ "Molecular properties of membrane-bound FAD-containing D-sorbitol dehydrogenase from thermotolerant Gluconobacter frateurii isolated from Thailand." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 1322, 3 ]

2

[]

0

true

Family

FAD-containing D-sorbitol dehydrogenase small subunit

FAD-SLDH_ssu

2

IPR024653

24,653

Peptidase, metallopeptidase M10/M27/M57

Peptidase_M10/M27/M57

Family

1,436

false

This entry represents the metallopeptidases M10, M27 and M57. The catalytic triad for proteases in this entry is HE-H-H, which in many members is in the sequence motif HEIGH [ ].

[]

0

[ "PFAM" ]

[ "PF12388" ]

[ "Peptidase_M57" ]

[ 1436 ]

1

[]

0

[]

0

[ "PUB00056093" ]

[ "9370274" ]

[ "Cloning and sequencing of two genes, prtA and prtB, from Myxococcus xanthus, encoding PrtA and PrtB proteases, both of which are required for the protease activity." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Cenarchaeum symbiosum (strain A)", "Eukaryota", "metagenome" ]

[ 1362, 1, 72, 1 ]

4

[]

0

true

Family

Peptidase, metallopeptidase M10/M27/M57

Peptidase_M10/M27/M57

9

IPR024655

24,655

Asl1-like, glycosyl hydrolase catalytic domain

Asl1_glyco_hydro_catalytic

Domain

7,835

false

This entry represents the glycosyl hydrolase catalytic core of a group of poorly characterised proteins, mainly from bacteria and fungi, including the cell wall protein Asl1 from S. pombe.

[]

0

[ "PFAM" ]

[ "PF11790" ]

[ "Glyco_hydro_cc" ]

[ 7835 ]

1

[]

0

[ "6uaq", "6uar", "6uas", "6uat", "6uau", "6uav", "6uaw", "6uax", "6uay", "6uaz", "6ub0", "6ub1", "6ub2", "6ub3", "6ub4", "6ub5", "6ub6", "6ub7", "6ub8", "6uba", "6ubb", "6ubc", "6ubd", "6ufl", "6ufz", "8j3x", "8j3y" ]

27

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Tetraselmis virus 1", "metagenomes" ]

[ 2081, 5726, 9, 1, 18 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1 ]

2

true

Domain

Asl1-like, glycosyl hydrolase catalytic domain

Asl1_glyco_hydro_catalytic

7

IPR024656

24,656

Ammonia monooxygenase, subunit A, archaeal

AmoA_arc

Family

23,482

false

This entry represents a group of archaeal proteins that contains ammonia monooxygenase subunit A. Ammonia monooxygenase is an enzyme that oxidises ammonia to nitrite and nitrate, thus playing a significant role in the nitrogen cycle. Ammonia-oxidising archaea (AOA) are widespread in marine environments [ ].

[]

0

[ "PFAM" ]

[ "PF12942" ]

[ "Archaeal_AmoA" ]

[ 23482 ]

1

[]

0

[]

0

[ "PUB00056094" ]

[ "16186488" ]

[ "Ubiquity and diversity of ammonia-oxidizing archaea in water columns and sediments of the ocean." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 23402, 37, 43 ]

3

[]

0

true

Family

Ammonia monooxygenase, subunit A, archaeal

AmoA_arc

1

IPR024657

24,657

COMPASS complex Set1 subunit, N-SET domain

COMPASS_Set1_N-SET

Domain

4,161

false

The COMPASS complex (complex proteins associated with Set1p) is conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF11764", "SM01291" ]

[ "N-SET", "N-SET" ]

[ 3877, 4093 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.354", "R-CEL-3214841", "R-CEL-8936459", "R-CEL-9772755", "R-DME-8936459", "R-DME-9772755", "R-HSA-3214841", "R-HSA-8936459", "R-HSA-9772755", "R-MMU-3214841", "R-MMU-8936459", "R-MMU-9772755", "R-SCE-3214841", "R-SCE-9772755", "R-SPO-3214841", "R-SPO-9772755", "R-XTR-8936459",...

[ "EC:2.1.1.354", "REACTOME:R-CEL-3214841", "REACTOME:R-CEL-8936459", "REACTOME:R-CEL-9772755", "REACTOME:R-DME-8936459", "REACTOME:R-DME-9772755", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-3214841", "REACTOME:R-MMU-8936459", "REACTOME:R-MMU-97...

18

[ "6bx3", "6ugm", "6uh5", "6ven" ]

4

[ "PUB00033368", "PUB00056095", "PUB00056096" ]

[ "11805083", "15775977", "16921172" ]

[ "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.", "Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.", "Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 met...

[ 2002, 2005, 2006 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4161 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 14, 1, 2, 6, 1, 6, 1, 1 ]

9

true

Domain

COMPASS complex Set1 subunit, N-SET domain

COMPASS_Set1_N-SET

6

IPR024659

24,659

Major capsid protein Gp5

Phage_coat_Gp5

Family

904

false

This family of proteins includes Gp5 from bacteriophage P22 and related proteins. Gp5 is involved in the formation of the pro-capsid shells in the bacteriophage. In total, there are 415 molecules of the coat protein which are arranged in an icosahedral shell [ ].

[]

0

[ "PFAM" ]

[ "PF11651" ]

[ "P22_CoatProtein" ]

[ 904 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2m5s", "2xyy", "2xyz", "3iyh", "3iyi", "5l35", "5uu5", "6mnt", "6mpo", "7sp4", "7spu", "8gn5", "8i1t", "8i1v", "8skg", "8u10", "8u11" ]

17

[ "PUB00056097" ]

[ "16709746" ]

[ "The structure of an infectious P22 virion shows the signal for headful DNA packaging." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 724, 2, 140, 38 ]

4

[]

0

true

Family

Major capsid protein Gp5

Phage_coat_Gp5

9

IPR024660

24,660

UNC-45/Cro1/She4, central domain

UCS_central_dom

Domain

4,997

false

The UNC-45 protein contain an NH2-terminal domain with three tetratricopeptide repeat motifs, a unique central domain, and a COOH-terminal domain homologous to CRO1 and She4 [ ]. This entry represents the central domain of the UNC-45 protein.

[]

0

[ "PFAM" ]

[ "PF11701" ]

[ "UNC45-central" ]

[ 4997 ]

1

[]

0

[ "3now", "3opb", "4i2w", "4i2z", "5mzu", "6qdk", "6qdl", "6qdm", "8brg", "8brh" ]

10

[ "PUB00056098", "PUB00056099", "PUB00056100", "PUB00075587" ]

[ "12356907", "18523008", "18478096", "9832550" ]

[ "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions.", "Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells.", "Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.", "Unc-45 mutations in Caeno...

[ 2002, 2008, 2008, 1998 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4997 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1, 2, 3, 3, 1, 8, 1 ]

8

true

Domain

UNC-45/Cro1/She4, central domain

UCS_central_dom

9

IPR024661

24,661

DNA-directed RNA polymerase III, subunit Rpc31

RNA_pol_III_Rpc31

Family

4,575

false

This entry represents the Rpc31 subunit. It is also known as RPC7 or RPC32 [ ]. DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-di...

[ "GO:0006383" ]

[ "transcription by RNA polymerase III" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF11705", "PIRSF000777", "PTHR15367" ]

[ "RNA_pol_3_Rpc31", "RNA_polIII_C31", "" ]

[ 4100, 1950, 4283 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-76061", "R-BTA-76066", "R-BTA-76071", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071", "R-SCE-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-BTA-76061", "REACTOME:R-BTA-76066", "REACTOME:R-BTA-76071", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "...

16

[ "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l", "7z1m", "7z1n", "7z1o", "7z2z"...

53

[ "PUB00000061", "PUB00033173", "PUB00056102", "PUB00076344" ]

[ "3052291", "10499798", "16877568", "18487626" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.", "Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III.", "Recruitment of RNA polymerase III in vivo." ]

[ 1988, 1999, 2006, 2008 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 17, 4558 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 8, 1, 7, 3, 1, 3, 6, 1, 1, 5 ]

12

true

Family

DNA-directed RNA polymerase III, subunit Rpc31

RNA_pol_III_Rpc31

7

IPR024662

24,662

Trafficking protein particle complex II-specific subunit 65

Trs65

Family

1,652

false

Trs65 is a specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase [ , , ]. TRAPP subunits are found in three forms-core TRAPP/TRAPPI, TRAPPII, and TRAPPIII [ ] and they function in various ...

[ "GO:0006891", "GO:1990071" ]

[ "intra-Golgi vesicle-mediated transport", "TRAPPII protein complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR28159" ]

[ "" ]

[ 1652 ]

1

[]

0

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00055557", "PUB00055565", "PUB00056101", "PUB00153720" ]

[ "11239471", "18801063", "17475775", "35080977" ]

[ "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.", "The TRAPP complex: insights into its architecture and function.", "The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex.", "Structural basis for assembly of TRAPPII complex and spec...

[ 2001, 2008, 2007, 2022 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1652 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

Trafficking protein particle complex II-specific subunit 65

Trs65

8

IPR024664

24,664

L-arabinose isomerase, C-terminal

Ara_Isoase_C

Domain

6,943

false

This entry represents a C-terminal non-catalytic domain in L-arabinose isomerase. This entry includes L-arabinose isomerases, AraA, ( ). These enzymes catalyse the reaction: L-arabinose => L-ribulose. This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-...

[]

0

[ "PFAM" ]

[ "PF11762" ]

[ "Arabinose_Iso_C" ]

[ 6943 ]

1

[ "EC" ]

[ "5.3.1.4" ]

[ "EC:5.3.1.4" ]

1

[ "2ajt", "2hxg", "4f2d", "4lql", "4r1o", "4r1p", "4r1q", "7ch3", "7chl", "7cwv", "7cx7", "7cxo", "7cyy" ]

13

[ "PUB00008241", "PUB00039308" ]

[ "9084180", "16756997" ]

[ "The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, genetic organization and expression.", "Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production." ]

[ 1997, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halorhabdus", "unclassified sequences" ]

[ 6837, 21, 3, 82 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

L-arabinose isomerase, C-terminal

Ara_Isoase_C

1

IPR024665

24,665

Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain

TSP/COMP_CC

Domain

4,041

false

Thrombospondins (TSP) are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. Cartilage oligomeric matrix protein (TSP5/COMP) may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as collagen and fibronectin [ , ]. TSP3/4...

[]

0

[ "PFAM" ]

[ "PF11598" ]

[ "COMP" ]

[ 4041 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-216083", "R-BTA-3000178", "R-HSA-186797", "R-HSA-216083", "R-HSA-3000178", "R-MMU-186797", "R-MMU-216083", "R-MMU-3000178", "R-RNO-186797", "R-RNO-216083", "R-RNO-3000178" ]

[ "REACTOME:R-BTA-216083", "REACTOME:R-BTA-3000178", "REACTOME:R-HSA-186797", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000178", "REACTOME:R-MMU-186797", "REACTOME:R-MMU-216083", "REACTOME:R-MMU-3000178", "REACTOME:R-RNO-186797", "REACTOME:R-RNO-216083", "REACTOME:R-RNO-3000178" ]

11

[ "1fbm", "1mz9", "1vdf", "3v2n", "3v2p", "3v2q", "3v2r" ]

7

[ "PUB00028489", "PUB00056104", "PUB00056105", "PUB00088886", "PUB00101529" ]

[ "9736606", "11084047", "12225811", "8820492", "12592708" ]

[ "All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein.", "Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and coll...

[ 1998, 2001, 2002, 1996, 2002 ]

5

[]

[ "IPR028507", "IPR039081" ]

0

2

0

[ "Eumetazoa" ]

[ 4041 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 4, 14, 9, 11 ]

5

true

Domain

Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain

TSP/COMP_CC

9

IPR024666

24,666

HnRNP M, nuclear localisation signal

HnRNP_M_PY-NLS

Domain

1,130

false

Heterogeneous nuclear ribonucleoproteins (hnRNPs) bind directly to nascent RNA polymerase II transcripts and play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs [ ]. hnRNP M proteins are an abundant group of hnRNPs that have been shown to bind avidly to poly(G) and poly(U)...

[]

0

[ "PFAM" ]

[ "PF11532" ]

[ "HnRNP_M_NLS" ]

[ 1130 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6803529", "R-HSA-72163", "R-HSA-72203" ]

[ "REACTOME:R-HSA-6803529", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72203" ]

3

[ "2ot8" ]

1

[ "PUB00048545", "PUB00056106", "PUB00056193" ]

[ "17435768", "17959601", "8441656" ]

[ "Structure-based design of a pathway-specific nuclear import inhibitor.", "Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons.", "The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucle...

[ 2007, 2007, 1993 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 1130 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 9, 7 ]

3

true

Domain

HnRNP M, nuclear localisation signal

HnRNP_M_PY-NLS

9

IPR024668

24,668

GA-binding protein alpha subunit, N-terminal

GABP_asu_N

Domain

1,483

false

GA-binding protein alpha is a transcription factor capable of interacting with purine rich repeats (GA repeats). This N-terminal domain found in the transcription factor GABP alpha consists of a five-stranded β-sheet crossed by a distorted helix and has been termed OST domain. The surface of the GABP alpha OST domain c...

[]

0

[ "PFAM" ]

[ "PF11620" ]

[ "GABP-alpha" ]

[ 1483 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-2151201", "R-HSA-2151201", "R-MMU-2151201" ]

[ "REACTOME:R-DME-2151201", "REACTOME:R-HSA-2151201", "REACTOME:R-MMU-2151201" ]

3

[ "2juo" ]

1

[ "PUB00048098" ]

[ "18295234" ]

[ "Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1483 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 5, 3, 4 ]

5

true

Domain

GA-binding protein alpha subunit, N-terminal

GABP_asu_N

5

IPR024671

24,671

Autophagy-related protein 22-like

Atg22-like

Family

16,278

false

Autophagy is a major survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxers, which mediate the efflux of leucine and other amino acids resulting from autophagy [ ]. This family also includes other transporter proteins.

[]

0

[ "PFAM" ]

[ "PF11700" ]

[ "ATG22" ]

[ 16278 ]

1

[]

0

[]

0

[ "PUB00056108" ]

[ "17204852" ]

[ "Permeases recycle amino acids resulting from autophagy." ]

[ 2007 ]

1

[]

[ "IPR044738" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 37, 11295, 4730, 216 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Autophagy-related protein 22-like

Atg22-like

5

IPR024672

24,672

Agglutinin-like protein, N-terminal

Agglutinin-like_N

Domain

458

false

This entry represents the N-terminal domain of yeast alpha-agglutinin [ ] and agglutinin-like (ALS) proteins. The ALS glycoproteins have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. The N-terminal domains of Candida albic...

[]

0

[ "PFAM", "SMART" ]

[ "PF11766", "SM01056" ]

[ "Candida_ALS_N", "Candida_ALS_N" ]

[ 458, 450 ]

2

[]

0

[ "2y7l", "2y7m", "2y7n", "2y7o", "2ylh", "4le8", "4leb", "4lee" ]

8

[ "PUB00056111", "PUB00056924", "PUB00074601", "PUB00153013", "PUB00153014" ]

[ "8741846", "21896717", "11292808", "24802757", "8455628" ]

[ "Identification of a ligand-binding site in an immunoglobulin fold domain of the Saccharomyces cerevisiae adhesion protein alpha-agglutinin.", "Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.", "Interaction of alpha-agglutinin and a-agglutinin, Saccharo...

[ 1996, 2011, 2001, 2014, 1993 ]

5

[]

0

null

[ "Dikarya" ]

[ 458 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Agglutinin-like protein, N-terminal

Agglutinin-like_N

5

IPR024673

24,673

Octaheme c-type cytochrome

Octahem_Cyt_c

Family

823

false

Members of this protein family bind heme covalently and contain eight (at least) CXXCH heme-binding motifs. A characterised member is the respiratory enzyme octaheme tetrathionate reductase from Shewanella [ ].

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF11783", "PIRSF039014", "TIGR04315" ]

[ "Cytochrome_cB", "OTR_cyc", "octaheme_Shew" ]

[ 822, 699, 668 ]

3

[]

0

[ "1sp3" ]

1

[ "PUB00031152" ]

[ "15361860" ]

[ "Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 19, 787, 17 ]

3

[]

0

true

Family

Octaheme c-type cytochrome

Octahem_Cyt_c

3

IPR024674

24,674

HpaB/PvcC/4-BUDH N-terminal

HpaB/PvcC/4-BUDH_N

Domain

6,846

false

This domain is found in the N terminus of HpaB, which encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [ ]. The enzyme is NADH-dependent and uses FAD as the redox chromophore. The domain is also found in pyoverdin chromophore biosynthetic protein (PvcC), which may play a role in one of the...

[]

0

[ "PFAM" ]

[ "PF11794" ]

[ "HpaB_N" ]

[ 6846 ]

1

[]

0

[ "1u8v", "2yyg", "2yyi", "2yyj", "2yyk", "2yyl", "2yym", "3hwc", "4g5e", "4oo2", "6b1b", "6eb0", "6jhm", "6qyh", "6qyi", "6vjr", "7dbw", "7e8p", "7e8q", "9bke", "9j9j", "9lft" ]

22

[ "PUB00007219", "PUB00007220", "PUB00056112" ]

[ "8077235", "10383985", "8344309" ]

[ "Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.", "The pvc gene cluster of Pseudomonas aeruginosa: role in synthesis of the pyoverdine chromophore and regulation by PtxR and PvdS.", "Purification and properties of an iron-sulfur and FAD-co...

[ 1994, 1999, 1993 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 454, 6124, 48, 220 ]

4

[]

0

true

Domain

HpaB/PvcC/4-BUDH N-terminal

HpaB/PvcC/4-BUDH_N

4

IPR024675

24,675

Eukaryotic translation initiation factor 3 subunit G, N-terminal

eIF3g_N

Domain

4,967

false

eIF-3G (also termed eIF-3 subunit 4, eIF-3-delta, eIF3-p42, or eIF3-p44) is the RNA-binding subunit of eIF3. Subunit eIF-3G binds 18 S rRNA and beta-globin mRNA, and therefore appears to be a nonspecific RNA-binding protein. It is one of the cytosolic targets and interacts with mature apoptosis-inducing factor (AIF). T...

[]

0

[ "PFAM", "CDD" ]

[ "PF12353", "cd12933" ]

[ "eIF3g", "eIF3G" ]

[ 4966, 3914 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME-72702", "R-DRE-156827", "R-DRE-72689", "R-DRE-72695", "R-DRE-72702", "R-HSA...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72695", "REACTOME:R-DDI-72702", "REACTOME:R-DME-156827", "REACTOME:R-DME-72649", "REACTOME:R-DME-72689", "...

49

[ "2mjc", "3jap", "4u1e", "5k0y", "6fyx", "6fyy", "6gsm", "6gsn", "6ybs", "6zce", "6zmw", "6zu9", "7qp6", "7qp7", "8cah", "8cas", "8oz0", "8pj1", "8pj2", "8pj3", "8pj4", "8pj5", "8pj6", "8ppl", "8xxm", "8xxn", "9bln", "9cpa" ]

28

[ "PUB00045290", "PUB00054024", "PUB00056123", "PUB00056124", "PUB00064778", "PUB00064795", "PUB00064796", "PUB00079576", "PUB00079577", "PUB00079578", "PUB00079579", "PUB00079580", "PUB00079581", "PUB00079582", "PUB00079583" ]

[ "17322308", "1742346", "10085088", "17581632", "18599441", "15703437", "14688252", "9362495", "20679478", "16322461", "16766523", "17094969", "14519125", "9973622", "9822659" ]

[ "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.", "Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes.", "Characterization of the p33 subunit of eukaryotic translation initiation...

[ 2007, 1991, 1999, 2007, 2008, 2005, 2004, 1997, 2010, 2005, 2006, 2006, 2003, 1999, 1998 ]

15

[]

0

null

[ "Eukaryota", "Mimiviridae sp. ChoanoV1", "metagenomes" ]

[ 4962, 1, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 3, 9, 3, 1, 4, 5, 1, 1, 3 ]

12

true

Domain

Eukaryotic translation initiation factor 3 subunit G, N-terminal

eIF3g_N

4

IPR024677

24,677

4-HPA 3-monooxygenase large component/Pyoverdin chromophore biosynthetic protein

HpaB/PvcC

Family

2,059

false

4-hydroxyphenylacetate (4HPA) 3-monooxygenase consists of two components, a large component, HpaB, which is an oxygenase, and a small component, HpaC, which is a reductase. 4-HPA 3-monooxygenase is NADH-dependent and uses FAD as the redox chromophore. HpaB utilises FADH2 supplied by HpaC to catalyse the hydroxylation o...

[]

0

[ "PIRSF" ]

[ "PIRSF500125" ]

[ "4_HPA_large" ]

[ 2059 ]

1

[]

0

[ "4oo2", "6b1b", "6eb0", "6qyh", "6qyi", "9bke" ]

6

[ "PUB00007220", "PUB00050164" ]

[ "10383985", "17804419" ]

[ "The pvc gene cluster of Pseudomonas aeruginosa: role in synthesis of the pyoverdine chromophore and regulation by PtxR and PvdS.", "Crystal structure of the oxygenase component (HpaB) of the 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8." ]

[ 1999, 2007 ]

2

[ "IPR004925" ]

[ "IPR012688" ]

1

0

[ "Bacteria", "Eumetazoa", "ecological metagenomes" ]

[ 2054, 2, 3 ]

3

[]

0

true

Family

4-HPA 3-monooxygenase large component/Pyoverdin chromophore biosynthetic protein

HpaB/PvcC

8

IPR024678

24,678

Serine/threonine-protein kinase OSR1/WNK, CCT domain

Kinase_OSR1/WNK_CCT

Domain

14,027

false

Oxidative-stress-responsive kinase 1 (OSR1) is involved in the signalling cascade which activates Na/K/2Cl co-transporter during osmotic stress. This entry represents the CCT domain found in OSR1, STE20/SPS1-related kinase and in WNK activators [ ]. This domain is found in eukaryotes, and is approximately 40 amino acid...

[ "GO:0004674", "GO:0005524" ]

[ "protein serine/threonine kinase activity", "ATP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF12202" ]

[ "OSR1_C" ]

[ 14027 ]

1

[ "EC", "REACTOME" ]

[ "2.7.11.1", "R-HSA-2672351" ]

[ "EC:2.7.11.1", "REACTOME:R-HSA-2672351" ]

2

[ "2lru", "2v3s", "5o2c", "6elm", "6fbk", "7o86", "7okw" ]

7

[ "PUB00049559" ]

[ "17721439" ]

[ "Structural insights into the recognition of substrates and activators by the OSR1 kinase." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 14026, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 2, 104, 5, 17, 23, 2, 33, 34 ]

9

true

Domain

Serine/threonine-protein kinase OSR1/WNK, CCT domain

Kinase_OSR1/WNK_CCT

8

IPR024679

24,679

Pre-rRNA-processing protein Ipi1, N-terminal

Ipi1_N

Domain

3,972

false

This entry represents a domain found in the N terminus of the pre-rRNA-processing protein Ipi1. This domain can also be found in testis-expressed sequence 10 protein (TEX10). In Saccharomyces cerevisiae, Ipi1 is a component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA [ , ].

[]

0

[ "PFAM" ]

[ "PF12333" ]

[ "Ipi1_N" ]

[ 3972 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

4

[ "6yle", "6ylg", "6ylh", "8fl2", "8fl3", "8fl4", "8pv4", "8pv6", "8pv8", "9dum" ]

10

[ "PUB00056113", "PUB00056114", "PUB00063002" ]

[ "15528184", "14759368", "15960975" ]

[ "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits.", "High-definition macromolecular composition of yeast RNA-processing complexes.", "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransfera...

[ 2004, 2004, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3972 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", ...

[ 1, 2, 1, 2, 3, 1, 4, 2, 1, 1, 1 ]

11

true

Domain

Pre-rRNA-processing protein Ipi1, N-terminal

Ipi1_N

8

IPR024680

24,680

Ribulose-1,5-bisphosphate carboxylase small subunit, N-terminal

RuBisCO_ssu_N

Domain

1,744

false

This domain is found in the N-terminal region of the small subunit of ribulose-1,5-bisphosphate in plants. It contains a conserved APF sequence motif. There are also two completely conserved residues (L and P) that may be functionally important [ ].

[]

0

[ "PFAM" ]

[ "PF12338" ]

[ "RbcS" ]

[ 1744 ]

1

[ "GP" ]

[ "GenProp1747" ]

[ "GP:GenProp1747" ]

1

[ "5iu0", "5wsk", "6kyi", "6kyj" ]

4

[ "PUB00075588" ]

[ "2101694" ]

[ "Nucleotide sequence of the small subunit of ribulose-1,5-bisphosphate carboxylase from the conifer Larix laricina." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 17, 1727 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 12, 5 ]

3

true

Domain

Ribulose-1,5-bisphosphate carboxylase small subunit, N-terminal

RuBisCO_ssu_N

5

IPR024682

24,682

Nuclear pore localisation protein Npl4, ubiquitin-like domain

Npl4_Ub-like_dom

Domain

3,382

false

Npl4, along with Ufd1, forms the heterodimer adaptor complex UN, which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a N-terminal ubiquitin-like domain which has within its structure a β-grasp fold with a helical insert [ ]. This entry represents the ubiquitin...

[]

0

[ "PFAM" ]

[ "PF11543" ]

[ "UN_NPL4" ]

[ 3382 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-110320", "R-DME-8951664", "R-DME-9755511", "R-HSA-110320", "R-HSA-8951664", "R-HSA-9755511", "R-MMU-110320", "R-MMU-8951664", "R-MMU-9755511", "R-RNO-110320", "R-RNO-8951664", "R-RNO-9755511", "R-SPO-110320", "R-SPO-8951664", "R-SPO-9755511" ]

[ "REACTOME:R-DME-110320", "REACTOME:R-DME-8951664", "REACTOME:R-DME-9755511", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9755511", "REACTOME:R-MMU-110320", "REACTOME:R-MMU-8951664", "REACTOME:R-MMU-9755511", "REACTOME:R-RNO-110320", "REACTOME:R-RNO-8951664", "REACTOME:R-...

15

[ "1wf9", "2pjh", "4rv0", "9m3z" ]

4

[ "PUB00048694" ]

[ "17491009" ]

[ "Detailed structural insights into the p97-Npl4-Ufd1 interface." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Orientia tsutsugamushi" ]

[ 3379, 3 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 8, 1, 1, 4, 4, 2, 7, 1 ]

8

true

Domain

Nuclear pore localisation protein Npl4, ubiquitin-like domain

Npl4_Ub-like_dom

1

IPR024684

24,684

Transcriptional activator PerC/bacteriophage SfV Orf40

Tscrpt_act_PerC/SfV_Orf40

Family

1,884

false

This family includes PerC, which is a transcriptional activator of EaeA/BfpA expression in enteropathogenic bacteria [ ]. It also includes a number of uncharacterised proteins, such as Orf40 from bacteriophage SfV.

[]

0

[ "PFAM" ]

[ "PF06069" ]

[ "PerC" ]

[ 1884 ]

1

[]

0

[]

0

[ "PUB00012250" ]

[ "7729884" ]

[ "A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli." ]

[ 1995 ]

1

[]

0

null

[ "Caudoviricetes", "Euroglyphus maynei", "Pseudomonadota" ]

[ 18, 1, 1865 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcriptional activator PerC/bacteriophage SfV Orf40

Tscrpt_act_PerC/SfV_Orf40

6

IPR024685

24,685

Adenylate cyclase class-I, N-terminal domain

Adenylate_cyclase_1_N

Domain

3,514

false

This entry represents the N-terminal domain of class-I adenylate cyclases. Adenylate cyclase is the enzyme responsible for the synthesis of cAMP from ATP. On the basis of sequence similarity, it has been proposed that there are three different classes of adenylate cyclases [ , ]. Class I cyclases are found in enterobac...

[]

0

[ "PFAM" ]

[ "PF12633" ]

[ "Adenyl_cycl_N" ]

[ 3514 ]

1

[ "EC" ]

[ "4.6.1.1" ]

[ "EC:4.6.1.1" ]

1

[]

0

[ "PUB00000015", "PUB00004943" ]

[ "8418825", "7863008" ]

[ "Phylogeny of adenylyl cyclases.", "Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes." ]

[ 1993, 1994 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3472, 4, 38 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Adenylate cyclase class-I, N-terminal domain

Adenylate_cyclase_1_N

4

IPR024686

24,686

Adenylate cyclase class-I, conserved site

Adenylate_cyclase_1_CS

Conserved_site

1,991

false

Adenylate cyclase is the enzyme responsible for the synthesis of cAMP from ATP. From sequence data, it has been proposed that there are three different classes of adenylate cyclases [ , ]. Class I cyclases are found in enterobacteria and related Gram-negative bacteria. They are proteins of about 850 residues that consi...

[]

0

[ "PROSITE", "PROSITE" ]

[ "PS01092", "PS01093" ]

[ "ADENYLATE_CYCLASE_1_1", "ADENYLATE_CYCLASE_1_2" ]

[ 1891, 1547 ]

2

[ "EC" ]

[ "4.6.1.1" ]

[ "EC:4.6.1.1" ]

1

[]

0

[ "PUB00000015", "PUB00004943" ]

[ "8418825", "7863008" ]

[ "Phylogeny of adenylyl cyclases.", "Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes." ]

[ 1993, 1994 ]

2

[]

0

null

[ "Bacteria", "Oryza sativa subsp. indica", "human gut metagenome" ]

[ 1988, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Conserved_site

Adenylate cyclase class-I, conserved site

Adenylate_cyclase_1_CS

8

IPR024687

24,687

MMS19, C-terminal

MMS19_C

Domain

4,502

false

This entry represents the C-terminal domain of MMS19. This domain shares homology with some HEAT repeat sequences. MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in...

[]

0

[ "PFAM" ]

[ "PF12460" ]

[ "MMS19_C" ]

[ 4502 ]

1

[ "REACTOME" ]

[ "R-HSA-2564830" ]

[ "REACTOME:R-HSA-2564830" ]

1

[ "6tbl", "6tc0", "8usp", "8usq" ]

4

[ "PUB00066660", "PUB00068841", "PUB00068842", "PUB00069921", "PUB00069922", "PUB00069925", "PUB00098185" ]

[ "21725325", "23585563", "20797633", "22678361", "22678362", "8943333", "32632277" ]

[ "Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.", "IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.", "MMXD, a TFIIH-independent XPD-MMS19 protein complex involv...

[ 2011, 2013, 2010, 2012, 2012, 1996, 2020 ]

7

[]

0

null

[ "Eukaryota" ]

[ 4502 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 4, 1, 3, 4, 1, 1, 3, 1, 1, 8 ]

11

true

Domain

MMS19, C-terminal

MMS19_C

4

IPR024688

24,688

Maltose/galactoside acetyltransferase domain

Mac_dom

Domain

18,658

false

This entry represents a domain found in maltose acetyltransferase, which is an enzyme uses acetyl-CoA as acetyl donor to acetylate cytoplasmic maltose [ ].

[ "GO:0016407" ]

[ "acetyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF12464", "SM01266" ]

[ "Mac", "Mac" ]

[ 18384, 17863 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

219

[ "1kqa", "1krr", "1kru", "1krv", "1ocx", "2ic7", "2p2o", "3ect", "3ftt", "3hjj", "3igj", "3nz2", "3srt", "3v4e", "4dcl", "4egg", "4isx", "5u2k", "5v0z", "6ag8" ]

20

[ "PUB00056117" ]

[ "1856235" ]

[ "Maltose transacetylase of Escherichia coli. Mapping and cloning of its structural, gene, mac, and characterization of the enzyme as a dimer of identical polypeptides with a molecular weight of 20,000." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Caudovirales sp. ct7964", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 14357, 1, 4007, 252, 41 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 1, 1 ]

4

true

Domain

Maltose/galactoside acetyltransferase domain

Mac_dom

6

IPR024689

24,689

Proteasome beta subunit, C-terminal

Proteasome_bsu_C

Domain

3,897

false

This domain is found in the C terminus of beta-type subunits of the proteasome, a multimeric complex that degrades proteins into peptides as part of the MHC class I-mediated Ag-presenting pathway [ ]. This domain is approximately 40 amino acids in length. It is found in association with . It contains a conserved GTT se...

[]

0

[ "PFAM" ]

[ "PF12465" ]

[ "Pr_beta_C" ]

[ 3897 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.25.1", "R-BTA-1236974", "R-BTA-1236978", "R-BTA-9907900", "R-BTA-9912633", "R-DDI-1236974", "R-DDI-1236978", "R-DDI-174084", "R-DDI-174154", "R-DDI-174178", "R-DDI-2467813", "R-DDI-349425", "R-DDI-382556", "R-DDI-450408", "R-DDI-4641258", "R-DDI-5632684", "R-DDI-5658442", "R-D...

[ "EC:3.4.25.1", "REACTOME:R-BTA-1236974", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-9907900", "REACTOME:R-BTA-9912633", "REACTOME:R-DDI-1236974", "REACTOME:R-DDI-1236978", "REACTOME:R-DDI-174084", "REACTOME:R-DDI-174154", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-2467813", "REACTOME:R-DDI-349425...

287

[ "1fnt", "1g0u", "1g65", "1iru", "1jd2", "1ryp", "1z7q", "2f16", "2fak", "2gpl", "2zcy", "3bdm", "3d29", "3dy3", "3dy4", "3e47", "3gpj", "3gpt", "3gpw", "3hye", "3jco", "3jcp", "3mg0", "3mg4", "3mg6", "3mg7", "3mg8", "3nzj", "3nzw", "3nzx", "3oeu", "3oev"...

503

[ "PUB00056118" ]

[ "11035083" ]

[ "Identification and characterization of a beta proteasome subunit cluster in the Japanese pufferfish (Fugu rubripes)." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3897 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 14, 8, 7, 5, 1, 8, 1, 1 ]

8

true

Domain

Proteasome beta subunit, C-terminal

Proteasome_bsu_C

5

IPR024690

24,690

Nitrile hydratase beta subunit domain

CN_hydtase_beta_dom_C

Domain

2,896

false

This entry represents the C-terminal domain of nitrile hydratase (NHase) beta subunit. Beta subunit consists of an N-terminal helical domain and a C-terminal SH3-like domain , ]. Thiocyanate hydrolase (SCNase) is a member of the NHase family, comprises alpha, beta and gamma subunits which share sequence similarities wi...

[]

0

[ "PFAM" ]

[ "PF02211" ]

[ "NHase_beta_C" ]

[ 2896 ]

1

[]

0

[ "1ahj", "1ire", "1ugp", "1ugq", "1ugr", "1ugs", "1v29", "2ahj", "2cyz", "2cz0", "2cz1", "2cz6", "2cz7", "2d0q", "2dd4", "2dd5", "2dpp", "2dxb", "2dxc", "2qdy", "2zcf", "2zpb", "2zpe", "2zpf", "2zpg", "2zph", "2zpi", "2zzd", "3a8g", "3a8h", "3a8l", "3a8m"...

73

[ "PUB00006378", "PUB00031767", "PUB00040218" ]

[ "9195885", "14717710", "17222425" ]

[ "Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold.", "Mutational and structural analysis of cobalt-containing nitrile hydratase on substrate and metal binding.", "Structure of thiocyanate hydrolase: a new nitrile hydratase family protein with a novel five-coordinate cobalt(III)...

[ 1997, 2004, 2007 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 2726, 106, 19, 45 ]

4

[]

0

true

Domain

Nitrile hydratase beta subunit domain

CN_hydtase_beta_dom_C

9

IPR024691

24,691

Micronemal protein 1, galectin-like domain

MIC1_galectin-like_dom

Domain

42

false

MIC1 is released as part of a complex by Toxoplasma gondii prior to invasion. The complex, which consists of MIC4-MIC1-MIC6, participates in host cell attachment and penetration, and is critical in invasion [ ]. MIC1 is a lactose-binding lectin [ ] required for the complex to leave the early compartments of the secreto...

[]

0

[ "PFAM" ]

[ "PF11476" ]

[ "TgMIC1" ]

[ 42 ]

1

[]

0

[ "2bvb", "2k2s" ]

2

[ "PUB00039773", "PUB00044345", "PUB00088283", "PUB00088284" ]

[ "16166092", "17491595", "11447133", "11157983" ]

[ "A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex.", "Atomic resolution insight into host cell recognition by Toxoplasma gondii.", "Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin.", "Identifi...

[ 2005, 2007, 2001, 2001 ]

4

[]

0

null

[ "Eukaryota" ]

[ 42 ]

1

[]

0

true

Domain

Micronemal protein 1, galectin-like domain

MIC1_galectin-like_dom

7

IPR024692

24,692

Phosphotransferase system, enzyme I

PTS_EI

Family

16,098

false

This entry represents phosphoenolpyruvate-protein phosphotransferase, also known as PTS enzyme I, which is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). PTS catalyses the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell m...

[ "GO:0008965", "GO:0009401" ]

[ "phosphoenolpyruvate-protein phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF000732" ]

[ "PTS_enzyme_I" ]

[ 16098 ]

1

[ "EC" ]

[ "2.7.3.9" ]

[ "EC:2.7.3.9" ]

1

[ "2hro", "2hwg", "2kx9", "2l5h", "2n5t", "2wqd", "2xdf" ]

7

[ "PUB00056141" ]

[ "9922238" ]

[ "Molecular characterization of the Lactococcus lactis ptsHI operon and analysis of the regulatory role of HPr." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 192, 15794, 7, 105 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphotransferase system, enzyme I

PTS_EI

6

IPR024694

24,694

PurE, prokaryotic type

PurE_prokaryotes

Family

24,853

false

The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a sin...

[ "GO:0006189" ]

[ "'de novo' IMP biosynthetic process" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF001338", "PTHR23046" ]

[ "AIR_carboxylase", "" ]

[ 23788, 24853 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "5.4.99.18", "PWY-6123", "PWY-7234" ]

[ "EC:5.4.99.18", "METACYC:PWY-6123", "METACYC:PWY-7234" ]

3

[ "1d7a", "1o4v", "1qcz", "1u11", "1xmp", "2ate", "2fw1", "2fw6", "2fw7", "2fw8", "2fw9", "2fwa", "2fwb", "2fwi", "2fwj", "2fwp", "2nsh", "2nsj", "2nsl", "2ywx", "3kuu", "3lp6", "3oow", "3opq", "3ors", "3rg8", "3rgg", "3trh", "4ay3", "4ay4", "4b4k", "4grd"...

52

[ "PUB00065601" ]

[ "21548610" ]

[ "Treponema denticola PurE Is a bacterial AIR carboxylase." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 844, 23113, 289, 2, 605 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 1, 1 ]

4

true

Family

PurE, prokaryotic type

PurE_prokaryotes

2

IPR024695

24,695

Uncharacterised conserved protein, UCP038861

UCP038861

Family

36

false

This entry represents a group of uncharacterised conserved proteins that may function as AAA ATPases or DNA and RNA helicases.

[]

0

[ "PIRSF" ]

[ "PIRSF038861" ]

[ "UCP038861" ]

[ 36 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteroidales" ]

[ 36 ]

1

[]

0

true

Family

Uncharacterised conserved protein, UCP038861

UCP038861

9

IPR024696

24,696

Uncharacterised conserved protein, UCP038601

UCP038601

Family

73

false

This entry represents a family of uncharacterised conserved proteins that may be related to the type VII secretion system ESAT-6-like proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF038601" ]

[ "UCP038601" ]

[ 73 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus" ]

[ 73 ]

1

[]

0

true

Family

Uncharacterised conserved protein, UCP038601

UCP038601

4

IPR024697

24,697

Uncharacterised conserved protein, UCP037923

UCP037923

Family

5

false

This entry represents a family of uncharacterised conserved bacterial proteins that contain trypsin and autotransporter beta domains [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF037923" ]

[ "UCP037923" ]

[ 5 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria" ]

[ 5 ]

1

[]

0

true

Family

Uncharacterised conserved protein, UCP037923

UCP037923

3

IPR024698

24,698

Capsular polysaccharide biosynthesis protein, Cps23fI-type, predicted

Caps_psacc_synth_Cps23fI-typ

Family

106

false

This entry represents a family of predicted Cps23fI-type capsular polysaccharide biosynthesis proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF030158" ]

[ "UCP030158" ]

[ 106 ]

1

[]

0

[]

0

[]

0

[ "IPR007657" ]

[]

1

0

1

[ "Bacteria" ]

[ 106 ]

1

[]

0

true

Family

Capsular polysaccharide biosynthesis protein, Cps23fI-type, predicted

Caps_psacc_synth_Cps23fI-typ

7

IPR024699

24,699

Acetoin utilization protein AcuA

AcuA

Family

1,652

false

AcuA is part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol [ ]. It is also a acetyltransferase that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis [ , ]. It has a role in cell growth and sporulation on acetoin or butanediol [ ], and ma...

[ "GO:0019152", "GO:0045150" ]

[ "acetoin dehydrogenase (NAD+) activity", "acetoin catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF021278" ]

[ "AcuA" ]

[ 1652 ]

1

[]

0

[ "2q04", "9g7f" ]

2

[ "PUB00043437", "PUB00043438", "PUB00055942", "PUB00056143" ]

[ "16855235", "18487328", "19136592", "7934817" ]

[ "Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilis.", "Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis.", "In Ba...

[ 2006, 2008, 2009, 1993 ]

4

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "bioreactor metagenome" ]

[ 1650, 1, 1 ]

3

[]

0

true

Family

Acetoin utilization protein AcuA

AcuA

8

IPR024700

24,700

Uncharacterised conserved protein, UCP020217

UCP020217

Family

343

false

This entry represents an uncharacterised conserved protein with nucleotidyltransferase domain.

[]

0

[ "PIRSF" ]

[ "PIRSF020217" ]

[ "UCP020217" ]

[ 343 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 337, 6 ]

2

[]

0

true

Family

Uncharacterised conserved protein, UCP020217

UCP020217

7

IPR024701

24,701

Voltage-dependent chloride channel 1/2

VCCN1/2

Family

496

false

This entry represents a family plant proteins, including Voltage-dependent chloride channel 1 and 2 (VCCN1/2, also known as BESTROPHIN-like protein 1/2) from Arabidopsis thaliana, which are voltage-dependent chloride channels required for ion transport and homeostasis across the thylakoid membrane to adjust photosynthe...

[ "GO:0005247", "GO:0042548" ]

[ "voltage-gated chloride channel activity", "regulation of photosynthesis, light reaction" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF016988" ]

[ "UCP016988" ]

[ 496 ]

1

[]

0

[ "7ek1", "7ek2", "7ek3" ]

3

[ "PUB00096749", "PUB00096750", "PUB00096751", "PUB00103560" ]

[ "27216227", "26947269", "31201341", "35523970" ]

[ "A voltage-dependent chloride channel fine-tunes photosynthesis in plants.", "A bestrophin-like protein modulates the proton motive force across the thylakoid membrane in Arabidopsis.", "K<sup>+</sup> and Cl<sup>-</sup> channels/transporters independently fine-tune photosynthesis in plants.", "Cryo-EM structu...

[ 2016, 2016, 2019, 2022 ]

4

[ "IPR044669" ]

[]

1

0

1

[ "Embryophyta" ]

[ 496 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 2, 3 ]

3

true

Family

Voltage-dependent chloride channel 1/2

VCCN1/2

2

IPR024703

24,703

Fascin, metazoans

Fascin_metazoans

Family

2,195

false

This family consists of several eukaryotic fascin proteins. Fascins are actin cross-linking proteins that function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [ ]. In humans there are three fascin isoforms identified: fascin1...

[ "GO:0030674", "GO:0051015" ]

[ "protein-macromolecule adaptor activity", "actin filament binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF005682" ]

[ "Fascin" ]

[ 2195 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6785807", "R-HSA-9662360", "R-HSA-9662361" ]

[ "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9662360", "REACTOME:R-HSA-9662361" ]

3

[ "1dfc", "3llp", "3p53", "4gov", "4goy", "4gp0", "4gp3", "6b0t", "6i0z", "6i10", "6i11", "6i12", "6i13", "6i14", "6i15", "6i16", "6i17", "6i18", "7zau", "8vo5", "8vo6", "8vo7", "8vo8", "8vo9", "8voa", "9fn6", "9gs6", "9gxi" ]

28

[ "PUB00012306", "PUB00071758" ]

[ "11948621", "24496629" ]

[ "Fascins, and their roles in cell structure and function.", "Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis." ]

[ 2002, 2014 ]

2

[ "IPR010431" ]

[]

1

0

1

[ "Opisthokonta" ]

[ 2195 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 6, 3, 8 ]

5

true

Family

Fascin, metazoans

Fascin_metazoans

1

IPR024704

24,704

Structural maintenance of chromosomes protein

SMC

Family

37,893

false

The SMC (structural maintenance of chromosomes) family of proteins, exist in virtually all organisms, including bacteria and archaea. The SMC proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. They function together with other proteins in a r...

[ "GO:0005524", "GO:0016887" ]

[ "ATP binding", "ATP hydrolysis activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF005719" ]

[ "SMC" ]

[ 37893 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2467813", "R-BTA-2468052", "R-BTA-2470946", "R-BTA-2500257", "R-BTA-3108214", "R-CEL-2299718", "R-CEL-2468052", "R-CEL-2470946", "R-CEL-2500257", "R-CEL-3108214", "R-DDI-2299718", "R-DDI-2468052", "R-DDI-2470946", "R-DDI-2500257", "R-DDI-2514853", "R-DDI-3108214", "R-HSA-12216...

[ "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2468052", "REACTOME:R-BTA-2470946", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-3108214", "REACTOME:R-CEL-2299718", "REACTOME:R-CEL-2468052", "REACTOME:R-CEL-2470946", "REACTOME:R-CEL-2500257", "REACTOME:R-CEL-3108214", "REACTOME:R-DDI-2299718", "REACTOM...

47

[ "6wg3", "6wge", "6yuf", "6yvd", "6yvu", "6yvv", "7ogt", "7q2x", "7q2y", "7qen", "7w1m", "9f5w" ]

12

[ "PUB00007542", "PUB00007543", "PUB00020349", "PUB00068474", "PUB00091722" ]

[ "12360193", "11983169", "10429180", "10811823", "11864377" ]

[ "The many functions of SMC proteins in chromosome dynamics.", "Molecular architecture of SMC proteins and the yeast cohesin complex.", "Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.", "The condensin complex governs chromosome condensati...

[ 2002, 2002, 1999, 2000, 2002 ]

5

[]

[ "IPR011890" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 705, 19256, 17614, 318 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 26, 5, 8, 13, 16, 11, 3, 8, 19, 4, 4, 29 ]

12

true

Family

Structural maintenance of chromosomes protein

SMC

1

IPR024705

24,705

Spermatogenesis-associated protein 20

Ssp411

Family

15,239

false

This entry represents spermatogenesis-associated protein 20 (also known as sperm-specific protein 411 (Ssp411)), which is a testis-specific protein that contains a thioredoxin-like domain, and may play a role in fertility regulation [ ]. Other family members include a number of uncharacterised proteins with thioredoxin...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF006402", "PTHR42899" ]

[ "UCP006402_thioredoxin", "" ]

[ 12788, 15239 ]

2

[]

0

[ "3ira", "7tkv" ]

2

[ "PUB00056144" ]

[ "15223837" ]

[ "Cloning and characterization of rat spermatid protein SSP411: a thioredoxin-like protein." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1012, 9416, 4296, 515 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 3, 2, 11, 1, 1, 5, 6, 7 ]

10

true

Family

Spermatogenesis-associated protein 20

Ssp411

8

IPR024706

24,706

Peroxiredoxin, AhpC-type

Peroxiredoxin_AhpC-typ

Family

66,856

false

1-Cys peroxiredoxin is a member of the peroxiredoxin superfamily, which protects cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to their corresponding alcohols [ ]. The enzyme's peroxidase activity is lost upon oxidation of the catalytic cysteine located up...

[]

0

[ "PIRSF" ]

[ "PIRSF000239" ]

[ "AHPC" ]

[ 66856 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "1.11.1", "1.11.1.24", "R-BTA-3299685", "R-BTA-5628897", "R-BTA-6798695", "R-BTA-9818027", "R-CEL-3299685", "R-CEL-5628897", "R-CEL-9818027", "R-DDI-3299685", "R-DDI-6798695", "R-DME-3299685", "R-DME-5628897", "R-DME-9818027", "R-GGA-3299685", "R-GGA-5628897", "R-GGA-9818027", "R-H...

[ "EC:1.11.1", "EC:1.11.1.24", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9818027", "REACTOME:R-CEL-3299685", "REACTOME:R-CEL-5628897", "REACTOME:R-CEL-9818027", "REACTOME:R-DDI-3299685", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-3299685", "RE...

45

[ "1e2y", "1n8j", "1prx", "1qmv", "1qq2", "1we0", "1x0r", "1xcc", "1xvw", "1xxu", "1yep", "1yex", "1yf0", "1yf1", "1zof", "1zye", "2bmx", "2c0d", "2cv4", "2cx3", "2cx4", "2e2g", "2e2m", "2h01", "2h66", "2i81", "2nvl", "2rii", "2v2g", "2v32", "2v41", "2ywn"...

134

[ "PUB00022453", "PUB00044127", "PUB00056145", "PUB00056146" ]

[ "9587003", "15004285", "17114262", "20969484" ]

[ "Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution.", "Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.", "Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress res...

[ 1998, 2004, 2007, 2011 ]

4

[]

[ "IPR017559", "IPR045020" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1940, 53254, 10875, 3, 784 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 3, 5, 13, 2, 11, 13, 1, 4, 11, 3, 1, 6 ]

13

true

Family

Peroxiredoxin, AhpC-type

Peroxiredoxin_AhpC-typ

7

IPR024707

24,707

Ferredoxin-thioredoxin reductase catalytic subunit, cyanobacteria-type

FTR_bsu_Cyanobacter

Family

695

false

Ferredoxin thioredoxin reductase is a [4FE-4S] protein present in organisms performing oxygenic photosynthesis, and plays an important role in the ferredoxin/thioredoxin regulatory chain. It converts an electron signal (photoreduced ferredoxin) to a thiol signal (reduced thioredoxin), regulating enzymes by reduction of...

[ "GO:0016730" ]

[ "oxidoreductase activity, acting on iron-sulfur proteins as donors" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF000260" ]

[ "FTRc" ]

[ 695 ]

1

[ "EC" ]

[ "1.8.7.2" ]

[ "EC:1.8.7.2" ]

1

[ "1dj7", "2pu9", "2puk", "2puo", "2pvd", "2pvg", "2pvo", "7bzk", "7c2b", "7c3f" ]

10

[ "PUB00048788", "PUB00056148", "PUB00075379" ]

[ "17611542", "7628465", "18003670" ]

[ "Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase.", "Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster.", "Binary reducing equivalent pathways using...

[ 2007, 1995, 2008 ]

3

[ "IPR004209" ]

[]

1

0

1

[ "Cyanobacteriota", "Eukaryota" ]

[ 337, 358 ]

2

[ "Zea mays" ]

[ 1 ]

1

true

Family

Ferredoxin-thioredoxin reductase catalytic subunit, cyanobacteria-type

FTR_bsu_Cyanobacter

6

IPR024708

24,708

Catalase active site

Catalase_AS

Active_site

32,887

false

Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [ ]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via tra...

[ "GO:0004096" ]

[ "catalase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS00438" ]

[ "CATALASE_2" ]

[ 32887 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.11.1.6", "R-BTA-3299685", "R-BTA-6798695", "R-BTA-9033241", "R-CFA-3299685", "R-CFA-6798695", "R-CFA-9033241", "R-DDI-3299685", "R-DDI-6798695", "R-DDI-9033241", "R-DME-3299685", "R-DME-6798695", "R-DME-9033241", "R-DRE-3299685", "R-DRE-6798695", "R-HSA-3299685", "R-HSA-6798695", ...

[ "EC:1.11.1.6", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9033241", "REACTOME:R-CFA-3299685", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-9033241", "REACTOME:R-DDI-3299685", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9033241", "REACTOME:R-DME-3299685", "REACTOME:R-DME-679...

32

[ "1a4e", "1cf9", "1dgb", "1dgf", "1dgg", "1dgh", "1e93", "1f4j", "1gge", "1ggj", "1ggk", "1gwe", "1gwf", "1gwh", "1h6n", "1h7k", "1hbz", "1iph", "1m7s", "1m85", "1mqf", "1nm0", "1p7y", "1p7z", "1p80", "1p81", "1qf7", "1qqw", "1qwl", "1qwm", "1qws", "1si8"...

150

[ "PUB00012765", "PUB00015054", "PUB00023264", "PUB00027249", "PUB00056180" ]

[ "11351128", "14745498", "9931255", "12557185", "9287428" ]

[ "Mitochondrial catalase and oxidative injury.", "Diversity of structures and properties among catalases.", "Structure of catalase-A from Saccharomyces cerevisiae.", "Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution.", "Phylogenetic relationships among prokaryotic and euka...

[ 2001, 2004, 1999, 2003, 1997 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Tupanvirus", "unclassified sequences" ]

[ 177, 21684, 10946, 4, 76 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 4, 2, 1, 1, 4, 8, 3, 5, 4, 2, 1, 12 ]

13

true

Active_site

Catalase active site

Catalase_AS

2

IPR024709

24,709

Putative O-fucosyltransferase, plant

FucosylTrfase_pln

Family

18,321

false

This entry represents a group of plant-specific O-fucosyltransferases and their homologues [ ]. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated pr...

[]

0

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF009360", "PTHR31288", "cd11299" ]

[ "UCP009360", "", "O-FucT_plant" ]

[ 14381, 3662, 16374 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[]

0

[ "PUB00075507", "PUB00085844", "PUB00085845" ]

[ "22629278", "12966037", "12868606" ]

[ "Plant Glycosyltransferases Beyond CAZy: A Perspective on DUF Families.", "A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs.", "The fucosyltransferase gene family: an amazing summary of the un...

[ 2012, 2003, 2003 ]

3

[ "IPR019378" ]

[]

1

0

1

[ "Eukaryota", "Megaviridae environmental sample" ]

[ 18320, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 137, 84, 224 ]

3

true

Family

Putative O-fucosyltransferase, plant

FucosylTrfase_pln

4

IPR024710

24,710

Tyramine--L-glutamate ligase

MfnD

Family

695

false

MfnD is a tyramine-glutamate ligase involved in methanofuran biosynthesis. Methanofuran is the first in a series of coenzymes involved in the reduction of carbon dioxide to methane. The crystal structure of the enzyme exhibits a classical ATP-grasp fold [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF016766" ]

[ "UCP016766_ATPgrasp" ]

[ 695 ]

1

[]

0

[ "3df7" ]

1

[ "PUB00074306" ]

[ "25211225" ]

[ "Identification and characterization of a tyramine-glutamate ligase (MfnD) involved in methanofuran biosynthesis." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 224, 457, 14 ]

3

[]

0

true

Family

Tyramine--L-glutamate ligase

MfnD

6

IPR024711

24,711

Catalase, mono-functional, haem-containing, clades 1 and 3

Catalase_clade1/3

Family

24,356

false

Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [ ]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via tra...

[ "GO:0004096", "GO:0020037", "GO:0006979" ]

[ "catalase activity", "heme binding", "response to oxidative stress" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF038928" ]

[ "Catalase_clade1-3" ]

[ 24356 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.11.1.6", "R-BTA-3299685", "R-BTA-6798695", "R-BTA-9033241", "R-CFA-3299685", "R-CFA-6798695", "R-CFA-9033241", "R-DDI-3299685", "R-DDI-6798695", "R-DDI-9033241", "R-DME-3299685", "R-DME-6798695", "R-DME-9033241", "R-DRE-3299685", "R-DRE-6798695", "R-HSA-3299685", "R-HSA-6798695", ...

[ "EC:1.11.1.6", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9033241", "REACTOME:R-CFA-3299685", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-9033241", "REACTOME:R-DDI-3299685", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9033241", "REACTOME:R-DME-3299685", "REACTOME:R-DME-679...

32

[ "1a4e", "1dgb", "1dgf", "1dgg", "1dgh", "1e93", "1f4j", "1gwe", "1gwf", "1gwh", "1h6n", "1h7k", "1hbz", "1m7s", "1m85", "1mqf", "1nm0", "1qqw", "1qwl", "1qwm", "1si8", "1tgu", "1th2", "1th3", "1th4", "2a9e", "2cag", "2cah", "2iqf", "2isa", "2j2m", "2xq1"...

79

[ "PUB00012765", "PUB00015054", "PUB00027249", "PUB00056180" ]

[ "11351128", "14745498", "12557185", "9287428" ]

[ "Mitochondrial catalase and oxidative injury.", "Diversity of structures and properties among catalases.", "Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution.", "Phylogenetic relationships among prokaryotic and eukaryotic catalases." ]

[ 2001, 2004, 2003, 1997 ]

4

[ "IPR018028" ]

[ "IPR040333" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 80, 15579, 8652, 45 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 4, 2, 5, 3, 7, 1, 4, 2, 2, 1, 11 ]

12

true

Family

Catalase, mono-functional, haem-containing, clades 1 and 3

Catalase_clade1/3

3

IPR024712

24,712

Catalase, mono-functional, haem-containing, clade 2

Catalase_clade2

Family

11,588

false

Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [ ]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via tra...

[ "GO:0004096", "GO:0020037", "GO:0006979" ]

[ "catalase activity", "heme binding", "response to oxidative stress" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF038927", "PTHR42821" ]

[ "Catalase_clade2", "" ]

[ 10660, 11588 ]

2

[ "EC" ]

[ "1.11.1.6" ]

[ "EC:1.11.1.6" ]

1

[ "1cf9", "1gg9", "1gge", "1ggf", "1ggh", "1ggj", "1ggk", "1iph", "1p7y", "1p7z", "1p80", "1p81", "1qf7", "1qws", "1sy7", "1ye9", "2iuf", "2xf2", "3ej6", "3p9p", "3p9q", "3p9r", "3p9s", "3pq2", "3pq3", "3pq4", "3pq5", "3pq6", "3pq7", "3pq8", "3ttt", "3ttu"...

81

[ "PUB00012765", "PUB00015054", "PUB00027249", "PUB00056180" ]

[ "11351128", "14745498", "12557185", "9287428" ]

[ "Mitochondrial catalase and oxidative injury.", "Diversity of structures and properties among catalases.", "Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution.", "Phylogenetic relationships among prokaryotic and eukaryotic catalases." ]

[ 2001, 2004, 2003, 1997 ]

4

[ "IPR018028" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Tupanvirus", "metagenomes" ]

[ 9034, 2425, 90, 4, 35 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 2 ]

2

true

Family

Catalase, mono-functional, haem-containing, clade 2

Catalase_clade2

3

IPR024713

24,713

Fructosamine deglycase FrlB

Fructosamine_deglycase_FrlB

Family

2,832

false

This group represents fructosamine deglycase FrlB, which catalyses the conversion of a range of fructosamine 6-phosphates to glucose 6-phosphate and a free amino acid [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF009290" ]

[ "FrlB" ]

[ 2832 ]

1

[]

0

[ "2a3n", "3eua", "3fkj", "8glr", "9otj", "9otl", "9otr", "9otu", "9ou5", "9ou6" ]

10

[ "PUB00056150" ]

[ "15556630" ]

[ "Identification of enzymes acting on alpha-glycated amino acids in Bacillus subtilis." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2826, 6 ]

2

[]

0

true

Family

Fructosamine deglycase FrlB

Fructosamine_deglycase_FrlB

6