LiteFold/InterPro · Datasets at Hugging Face

IPR024715

24,715

Coagulation factor 5/8-like

Factor_5/8-like

Family

3,060

false

This entry represents coagulation factors V and VIII, as well as other members of the multicopper oxidase family including the functionally similar venom prothrombin activator subunits, and the possible ferroxidase, hephaestin. Mammalian coagulation factors V and VIII play analogous roles as non-enzymatic cofactors in ...

[]

0

[ "PIRSF" ]

[ "PIRSF000354" ]

[ "Factors_V_VIII" ]

[ 3060 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-114608", "R-HSA-140837", "R-HSA-140875", "R-HSA-163841", "R-HSA-204005", "R-HSA-381426", "R-HSA-5694530", "R-HSA-8957275", "R-HSA-9672383", "R-HSA-9672387", "R-HSA-9672391", "R-HSA-9672393", "R-HSA-9672395", "R-HSA-9672396", "R-HSA-9672397", "R-HSA-9673202", "R-HSA-9674519", ...

[ "REACTOME:R-HSA-114608", "REACTOME:R-HSA-140837", "REACTOME:R-HSA-140875", "REACTOME:R-HSA-163841", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-5694530", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-9672383", "REACTOME:R-HSA-9672387", "REACTOME:R-HSA-9672391", "REACTOME:R-HS...

31

[ "2r7e", "3cdz", "3j2q", "4bdv", "4bxs", "5k8d", "5n0k", "6mf0", "6mf2", "7k66", "7kbt", "7kve", "7kvf", "7kwo", "8fdg", "8g6i", "8tn9", "8ty1", "9jbv" ]

19

[ "PUB00027871", "PUB00031000" ]

[ "9834200", "15184653" ]

[ "The life cycle of coagulation factor VIII in view of its structure and function.", "The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function." ]

[ 1998, 2004 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 3060 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 9, 14 ]

4

true

Family

Coagulation factor 5/8-like

Factor_5/8-like

2

IPR024717

24,717

Denitrification system component NapC/NirT/NrfH

NapC/NirT/NrfH

Family

3,564

false

This family includes NapC, a predicted membrane-anchored four-heme c-type cytochrome that forms one component of the periplasmic nitrate reductase along with NapA, NapB, NapD, NapE, and NapF subunits. The family also includes the nitrite reductase component NirT, and NrfH - a subunit of the nitrite reductase complex th...

[ "GO:0020037", "GO:0019333", "GO:0016020" ]

[ "heme binding", "denitrification pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF000013" ]

[ "4_hem_cytochrm_NapC" ]

[ 3564 ]

1

[]

0

[ "2j7a", "2vr0" ]

2

[ "PUB00043066" ]

[ "10672190" ]

[ "A NapC/NirT-type cytochrome c (NrfH) is the mediator between the quinone pool and the cytochrome c nitrite reductase of Wolinella succinogenes." ]

[ 2000 ]

1

[]

[ "IPR011885", "IPR017571" ]

0

2

0

[ "Anopheles maculatus", "Bacteria", "metagenomes" ]

[ 1, 3525, 38 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Denitrification system component NapC/NirT/NrfH

NapC/NirT/NrfH

4

IPR024719

24,719

HpaB/PvcC/4-BUDH C-terminal

HpaB/PvcC/4-BUDH_C

Domain

6,798

false

This C-terminal domain is found in HpaB, which encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [ ]. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This domain is also found in pyoverdin chromophore biosynthetic protein PvcC, which may play a role in one of the propose...

[]

0

[ "PFAM" ]

[ "PF03241" ]

[ "HpaB" ]

[ 6798 ]

1

[]

0

[ "1u8v", "2yyg", "2yyi", "2yyj", "2yyk", "2yyl", "2yym", "3hwc", "4g5e", "4oo2", "6b1b", "6eb0", "6jhm", "6qyh", "6qyi", "6vjr", "7dbw", "7e8p", "7e8q", "9bke", "9j9j", "9lft" ]

22

[ "PUB00007219", "PUB00007220", "PUB00056112" ]

[ "8077235", "10383985", "8344309" ]

[ "Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.", "The pvc gene cluster of Pseudomonas aeruginosa: role in synthesis of the pyoverdine chromophore and regulation by PtxR and PvdS.", "Purification and properties of an iron-sulfur and FAD-co...

[ 1994, 1999, 1993 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 459, 6087, 45, 207 ]

4

[]

0

true

Domain

HpaB/PvcC/4-BUDH C-terminal

HpaB/PvcC/4-BUDH_C

2

IPR024721

24,721

Snurportin-1, N-terminal

Snurportin-1_N

Domain

1,251

false

Snurportin-1 is a nuclear import receptor that contains an N-terminal importin beta binding domain which is essential for its function as an snRNP-specific nuclear import receptor [ ]. Snurportin-1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and di...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11538" ]

[ "Snurportin1" ]

[ 1251 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-191859", "R-HSA-191859", "R-MMU-191859", "R-RNO-191859" ]

[ "REACTOME:R-BTA-191859", "REACTOME:R-HSA-191859", "REACTOME:R-MMU-191859", "REACTOME:R-RNO-191859" ]

4

[ "2p8q", "2q5d", "2qna", "3gb8", "3gjx", "3lww", "3nby", "3nbz", "3nc0", "5dis" ]

10

[ "PUB00033726" ]

[ "9670026" ]

[ "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure." ]

[ 1998 ]

1

[ "IPR002652" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1251 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 12, 6, 1, 6 ]

5

true

Domain

Snurportin-1, N-terminal

Snurportin-1_N

6

IPR024723

24,723

Termicin

Family

166

false

Termicin is a cysteine-rich antifungal peptide, which also exhibits weak antibacterial activity. The global fold of termicin consists of an α-helical segment and a two-stranded antiparallel β-sheet forming a cysteine stabilised alphabeta motif that is also found in antibacterial and antifungal defensins from insects an...

[]

0

[ "PFAM" ]

[ "PF11415" ]

[ "Toxin_37" ]

[ 166 ]

1

[]

0

[ "1mm0" ]

1

[ "PUB00028964" ]

[ "12592014" ]

[ "Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger." ]

[ 2003 ]

1

[]

0

null

[ "Blattodea" ]

[ 166 ]

1

[]

0

true

Family

Termicin

9

IPR024724

24,724

Molybdenum cofactor biosynthesis protein F, N-terminal

MoaF_N

Domain

1,264

false

This entry represents the N-terminal domain of MoaF. Molybdenum cofactor biosynthesis protein F (MoaF) is essential for the production of the monoamine-inducible 30kDa protein in Klebsiella [ ]. It is necessary for reconstituting organoautotrophic growth in Ralstonia eutropha [ ]. MoaF is conserved in proteobacteria an...

[]

0

[ "PFAM" ]

[ "PF10703" ]

[ "MoaF" ]

[ 1264 ]

1

[]

0

[ "4q51" ]

1

[ "PUB00044372", "PUB00044373" ]

[ "7590328", "11545279" ]

[ "A Klebsiella aerogenes moaEF operon is controlled by the positive MoaR regulator of the monoamine regulon.", "Involvement of an unusual mol operon in molybdopterin cofactor biosynthesis in Ralstonia eutropha." ]

[ 1995, 2001 ]

2

[]

0

null

[ "Bacteria", "Halobacteriales", "Opisthokonta", "ecological metagenomes" ]

[ 1092, 2, 165, 5 ]

4

[]

0

true

Domain

Molybdenum cofactor biosynthesis protein F, N-terminal

MoaF_N

7

IPR024725

24,725

E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain

UBR5_UBA

Domain

2,600

false

This entry represents the N-terminal ubiquitin-associated (UBA) domain (also known as CUE domain) of UBR5 and similar animal proteins. Ubiquitin is recognised by helices alpha-1 and -3 in in the UBA domain. UBR5 binds to mono-ubiquitinated proteins [ ]. E3 ubiquitin-protein ligase UBR5 (also known as E3 ligase identifi...

[ "GO:0043130" ]

[ "ubiquitin binding" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF11547", "cd14423" ]

[ "E3_UbLigase_EDD", "CUE_UBR5" ]

[ 2600, 2531 ]

2

[ "EC", "METACYC" ]

[ "2.3.2.26", "PWY-7511" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511" ]

2

[ "2qho", "8bja", "8c06", "8c07", "8d4x", "8e0q", "8ewi", "8p82", "8p83" ]

9

[ "PUB00049002", "PUB00103316", "PUB00103317", "PUB00103319", "PUB00103320", "PUB00103321", "PUB00103322", "PUB00103323", "PUB00103324", "PUB00103325", "PUB00103326", "PUB00103327", "PUB00103328", "PUB00103329", "PUB00103330", "PUB00103331", "PUB00103332", "PUB00103333", "PUB001033...

[ "17897937", "20167605", "24441042", "23027739", "27590582", "28330927", "26464214", "27299863", "29742019", "30038412", "27647897", "29441938", "28689657", "21127351", "24438055", "26224628", "27721409", "28559278", "29296225", "28856538", "32339205" ]

[ "Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD.", "Modulation of myocardin function by the ubiquitin E3 ligase UBR5.", "Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein level...

[ 2007, 2010, 2015, 2012, 2016, 2017, 2015, 2016, 2018, 2018, 2016, 2017, 2017, 2011, 2014, 2015, 2017, 2017, 2017, 2017, 2020 ]

21

[]

0

null

[ "Eukaryota" ]

[ 2600 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 33, 4, 2, 4, 2 ]

6

true

Domain

E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain

UBR5_UBA

9

IPR024726

24,726

Ferric siderophore reductase, C-terminal

FhuF_C

Domain

6,738

false

Ferric siderophore reductase (FhuF) is a siderophore-iron reductase involved in iron removal from the hydroxamate-type siderophores coprogen, ferrichrome and ferrioxamine B after their transport into the cell [ , ]. It binds both the iron-loaded and the apo forms of ferrichrome [ ]. This entry represents the C-terminal...

[ "GO:0051537" ]

[ "2 iron, 2 sulfur cluster binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11575" ]

[ "FhuF_C" ]

[ 6738 ]

1

[]

0

[ "7qp5" ]

1

[ "PUB00010339", "PUB00055062", "PUB00101361" ]

[ "9990318", "14756576", "33559753" ]

[ "FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center.", "FhuF, part of a siderophore-reductase system.", "Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli." ]

[ 1998, 2004, 2021 ]

3

[]

0

null

[ "Aduncisulcus paluster", "Bacteria", "unclassified sequences" ]

[ 1, 6710, 27 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Ferric siderophore reductase, C-terminal

FhuF_C

2

IPR024727

24,727

NAD-glutamate dehydrogenase, N-terminal ACT1 domain

NAD_Glu_DH_N_ACT1

Domain

9,178

false

This entry represents the first ACT-like domain (ACT1) found at the N-terminal of a bacterial family of NAD-specific glutamate dehydrogenases. The ACT domains of these proteins differ from the archetypal ACT fold in that strand strand β1 is located in the position usually occupied by strand β4 creating an ACT-like topo...

[]

0

[ "PFAM" ]

[ "PF21075" ]

[ "GDH_ACT1" ]

[ 9178 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.4.1.2", "PWY-5022", "PWY-6728", "PWY-7126", "PWY-8190" ]

[ "EC:1.4.1.2", "METACYC:PWY-5022", "METACYC:PWY-6728", "METACYC:PWY-7126", "METACYC:PWY-8190" ]

5

[ "7a1d", "7jsr" ]

2

[ "PUB00010144", "PUB00151573" ]

[ "10924516", "34083757" ]

[ "A new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus.", "3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme." ]

[ 2000, 2021 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9100, 21, 57 ]

3

[]

0

true

Domain

NAD-glutamate dehydrogenase, N-terminal ACT1 domain

NAD_Glu_DH_N_ACT1

2

IPR024729

24,729

Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain

USP7_ICP0-binding_dom

Domain

8,965

false

This domain is found in proteins of the peptidase C19 family, which contains ubiquitinyl hydrolases like ubiquitin carboxyl-terminal hydrolase 7 (USP7) [ ]. This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. It is found to interact with the herpesvirus 1 trans-acting transcrip...

[]

0

[ "PFAM" ]

[ "PF12436" ]

[ "USP7_ICP0_bdg" ]

[ 8965 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.19.12", "R-CEL-5689880", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-8866652", "R-CEL-8948747", "R-DME-5689880", "R-DME-6781823", "R-DME-6782135", "R-DME-6782210", "R-DME-6804757", "R-DME-8866652", "R-DME-8948747", "R-HSA-5689880", "R-HSA-6781823", "R-HSA-6781827",...

[ "EC:3.4.19.12", "REACTOME:R-CEL-5689880", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-8866652", "REACTOME:R-CEL-8948747", "REACTOME:R-DME-5689880", "REACTOME:R-DME-6781823", "REACTOME:R-DME-6782135", "REACTOME:R-DME-6782210", "REACTOME:R-DME-68...

48

[ "2kvr", "2ylm", "4pyz", "4wph", "4wpi", "4yoc", "4z96", "4z97", "5c56", "5c6d", "5fwi", "5gg4", "5j7t", "6p5l", "7vij", "7xpy", "9k2w", "9k2x" ]

18

[ "PUB00056219" ]

[ "14506283" ]

[ "Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Pandoravirus" ]

[ 8944, 21 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 16, 8, 2, 7, 3, 1, 16, 6, 1, 2, 97 ]

12

true

Domain

Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain

USP7_ICP0-binding_dom

4

IPR024730

24,730

Merozoite surface protein, EGF domain 1

MSP1_EGF_1

Domain

2,805

false

This EGF-like domain is found at the C terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite [ ].

[]

0

[ "PFAM" ]

[ "PF12946" ]

[ "EGF_MSP1_1" ]

[ 2805 ]

1

[]

0

[ "1b9w", "1cej", "1n1i", "1ob1", "2flg", "2mgp", "2mgr", "2npr", "6xqw", "6zbc", "6zbd", "6zbe", "6zbf", "6zbg", "6zbh", "6zbj", "6zbl", "8dfg", "8dfh", "8dfi" ]

20

[ "PUB00023926" ]

[ "10339410" ]

[ "Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2805 ]

1

[]

0

true

Domain

Merozoite surface protein, EGF domain 1

MSP1_EGF_1

6

IPR024731

24,731

NELL2-like, EGF domain

NELL2-like_EGF

Domain

32,008

false

This entry represents an EGF domain found in several proteins, including NELL2, Cubilin, Uromodulin, Fibrillin and related proteins that contain EGF repeats. Some of these proteins have calcium-binding properties. NELL2 is almost exclusively expressed in the nervous system. In the mammalian brain, NELL2 expression is m...

[]

0

[ "PFAM" ]

[ "PF12947" ]

[ "EGF_3" ]

[ 32008 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1474228", "R-BTA-1566948", "R-BTA-2129379", "R-BTA-216083", "R-BTA-2173789", "R-BTA-381426", "R-BTA-8957275", "R-DRE-5362798", "R-HSA-1474228", "R-HSA-1566948", "R-HSA-186797", "R-HSA-196791", "R-HSA-2129379", "R-HSA-2142845", "R-HSA-216083", "R-HSA-2160916", "R-HSA-2173789", ...

[ "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1566948", "REACTOME:R-BTA-2129379", "REACTOME:R-BTA-216083", "REACTOME:R-BTA-2173789", "REACTOME:R-BTA-381426", "REACTOME:R-BTA-8957275", "REACTOME:R-DRE-5362798", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1566948", "REACTOME:R-HSA-186797", "REACTOME:R...

51

[ "1b9w", "1gl4", "1n1i", "1yo8", "2npr", "2rhp", "6pog", "6pol", "6tqk", "6zs5", "6zya", "7pfp", "7q3n", "9nu1", "9nu2", "9nu3" ]

16

[ "PUB00023926", "PUB00160780" ]

[ "10339410", "18547942" ]

[ "Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1.", "NELL2, a neuron-specific EGF-like protein, is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty." ]

[ 1999, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 115, 31888, 5 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 30, 83, 5, 63, 47, 3, 71 ]

7

true

Domain

NELL2-like, EGF domain

NELL2-like_EGF

9

IPR024732

24,732

Alpha-N-acetylglucosaminidase, C-terminal

NAGLU_C

Domain

5,773

false

Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate [ ]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB, or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mi...

[]

0

[ "PFAM" ]

[ "PF12972" ]

[ "NAGLU_C" ]

[ 5773 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2024096", "R-HSA-2206282" ]

[ "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-2206282" ]

2

[ "2vc9", "2vca", "2vcb", "2vcc", "4a4a", "4xwh", "7mfk", "7mfl" ]

8

[ "PUB00010190", "PUB00010191", "PUB00049672" ]

[ "10588735", "12049639", "18443291" ]

[ "Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase.", "Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer.", "Structural and mechanistic insight into the basis of mucopolysaccharidosis I...

[ 1999, 2002, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2266, 3487, 20 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 3, 1, 5, 2, 3, 3, 20 ]

9

true

Domain

Alpha-N-acetylglucosaminidase, C-terminal

NAGLU_C

9

IPR024733

24,733

Alpha-N-acetylglucosaminidase, tim-barrel domain

NAGLU_tim-barrel

Domain

6,045

false

Alpha-N-acetylglucosaminidase is a lysosomal enzyme that is required for the stepwise degradation of heparan sulphate [ ]. Mutations on the alpha-N-acetylglucosaminidase gene can lead to mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B), characterised by neurological dysfunction but relatively m...

[]

0

[ "PFAM" ]

[ "PF05089" ]

[ "NAGLU" ]

[ 6045 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2024096", "R-HSA-2206282" ]

[ "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-2206282" ]

2

[ "2vc9", "2vca", "2vcb", "2vcc", "4a4a", "4xwh", "7mfk", "7mfl" ]

8

[ "PUB00010190", "PUB00010191", "PUB00049672" ]

[ "10588735", "12049639", "18443291" ]

[ "Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase.", "Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer.", "Structural and mechanistic insight into the basis of mucopolysaccharidosis I...

[ 1999, 2002, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2290, 3736, 19 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 3, 1, 10, 2, 5, 4, 21 ]

9

true

Domain

Alpha-N-acetylglucosaminidase, tim-barrel domain

NAGLU_tim-barrel

7

IPR024735

24,735

Conjugative transposon protein TcpC

TcpC

Family

2,688

false

TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG [ ]. Its C-terminal domain is critical for inter...

[]

0

[ "PFAM" ]

[ "PF12642" ]

[ "TpcC" ]

[ 2688 ]

1

[]

0

[ "3ub1", "6zgn", "7pkw", "8s7l" ]

4

[ "PUB00056223", "PUB00085748" ]

[ "16788202", "22150951" ]

[ "Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens.", "The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria." ]

[ 2006, 2012 ]

2

[]

0

null

[ "Acrobeloides nanus", "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1, 2676, 2, 9 ]

4

[]

0

true

Family

Conjugative transposon protein TcpC

TcpC

3

IPR024736

24,736

Oestrogen-type nuclear receptor final C-terminal domain

Oestrogen-typ_rcpt_final_C_dom

Domain

739

false

This is the very C-terminal region of a subfamily of nuclear receptors that includes oestrogen receptors and other subfamily 3 group A members. The actual function of this region is not known, but the domain is absent from all the other types of nuclear receptors. Oestrogen receptors modulate AP-1-dependent transcripti...

[]

0

[ "PFAM" ]

[ "PF12743" ]

[ "ESR1_C" ]

[ 739 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1251985", "R-BTA-1257604", "R-BTA-383280", "R-BTA-4090294", "R-BTA-5689896", "R-BTA-6811558", "R-BTA-8866910", "R-BTA-8931987", "R-BTA-8939211", "R-BTA-9009391", "R-BTA-9018519", "R-BTA-9841251", "R-HSA-1251985", "R-HSA-1257604", "R-HSA-2219530", "R-HSA-383280", "R-HSA-4090294...

[ "REACTOME:R-BTA-1251985", "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-383280", "REACTOME:R-BTA-4090294", "REACTOME:R-BTA-5689896", "REACTOME:R-BTA-6811558", "REACTOME:R-BTA-8866910", "REACTOME:R-BTA-8931987", "REACTOME:R-BTA-8939211", "REACTOME:R-BTA-9009391", "REACTOME:R-BTA-9018519", "REACTOME...

63

[ "2ocf", "7opw", "7oq7", "7oq8" ]

4

[ "PUB00056224", "PUB00056225" ]

[ "10751636", "15196329" ]

[ "Estrogen receptor interaction with co-activators and co-repressors.", "Estrogen receptor-dependent activation of AP-1 via non-genomic signalling." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 739 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 4, 7 ]

3

true

Domain

Oestrogen-type nuclear receptor final C-terminal domain

Oestrogen-typ_rcpt_final_C_dom

7

IPR024738

24,738

Transcriptional coactivator Hfi1/Transcriptional adapter 1

Hfi1/Tada1

Family

5,796

false

The yeast Spt-Ada-Gcn5-Acetyl (SAGA) transferase complex is a multifunctional coactivator involved in multiple cellular processes [ ], including regulation of transcription by RNA polymerase II [ , ]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA ...

[ "GO:0070461" ]

[ "SAGA-type complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF12767", "PTHR21277" ]

[ "SAGA-Tad1", "" ]

[ 5715, 5519 ]

2

[ "GP", "REACTOME" ]

[ "GenProp2053", "R-HSA-3214847" ]

[ "GP:GenProp2053", "REACTOME:R-HSA-3214847" ]

2

[ "6t9i", "6t9k", "6tb4", "6tbm", "7ktr", "7kts", "8h7g" ]

7

[ "PUB00056231", "PUB00056232", "PUB00056233", "PUB00056234" ]

[ "12898711", "15260971", "11564863", "17694076" ]

[ "NET1 and HFI1 genes of yeast mediate both chromosome maintenance and mitochondrial rho(-) mutagenesis.", "Molecular architecture of the S. cerevisiae SAGA complex.", "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in...

[ 2003, 2004, 2001, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5796 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 21, 1, 5, 1, 1, 1, 15, 6, 1, 1, 29 ]

11

true

Family

Transcriptional coactivator Hfi1/Transcriptional adapter 1

Hfi1/Tada1

8

IPR024739

24,739

Protein tyrosine phosphatase, receptor type, N-terminal

PTP_recept_N

Domain

555

false

Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is ...

[]

0

[ "PFAM" ]

[ "PF12453" ]

[ "PTP_N" ]

[ 555 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.48", "R-HSA-202427", "R-HSA-416700", "R-HSA-6798695", "R-MMU-202427", "R-MMU-416700", "R-MMU-6798695", "R-RNO-202427", "R-RNO-416700", "R-RNO-6798695" ]

[ "EC:3.1.3.48", "REACTOME:R-HSA-202427", "REACTOME:R-HSA-416700", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-202427", "REACTOME:R-MMU-416700", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-202427", "REACTOME:R-RNO-416700", "REACTOME:R-RNO-6798695" ]

10

[]

0

[ "PUB00035793", "PUB00035794", "PUB00035795", "PUB00035796", "PUB00035797", "PUB00035798" ]

[ "9818190", "14625689", "12678841", "16672235", "8948575", "9646865" ]

[ "Protein tyrosine phosphatases: mechanisms of catalysis and regulation.", "Receptor and nonreceptor protein tyrosine phosphatases in the nervous system.", "An overview of the protein tyrosine phosphatase superfamily.", "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase dom...

[ 1998, 2003, 2003, 2006, 1996, 1998 ]

6

[]

0

null

[ "Tetrapoda" ]

[ 555 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 8, 6 ]

3

true

Domain

Protein tyrosine phosphatase, receptor type, N-terminal

PTP_recept_N

2

IPR024740

24,740

Hen1, N-terminal

Hen1_N

Domain

2,430

false

This entry represents the N-terminal domain of the bacterial Hen1 protein, which is a 3' terminal RNA ribose 2'-O-methyltransferase that is involved in bacterial RNA repair [ ]. Hen1 forms a heterotetramer with Pnkp. The heterotetramer has been shown to repair transfer RNAs cleaved by ribotoxins in vitro [ ]. The N-ter...

[]

0

[ "PFAM" ]

[ "PF12623" ]

[ "Hen1_L" ]

[ 2430 ]

1

[]

0

[ "4dqz", "4drf", "4e6n" ]

3

[ "PUB00055068", "PUB00056235" ]

[ "20007328", "19815768" ]

[ "Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette.", "Reconstituting bacterial RNA repair and modification in vitro." ]

[ 2010, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2424, 4, 2 ]

3

[]

0

true

Domain

Hen1, N-terminal

Hen1_N

1

IPR024741

24,741

Condensin-2 complex subunit G2

Condensin2_G2

Family

2,265

false

Subunit G2 is a non-SMC subunit of condensin II, which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex i...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF12422" ]

[ "Condensin2nSMC" ]

[ 2265 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-2299718", "R-HSA-2299718", "R-MMU-2299718" ]

[ "REACTOME:R-DRE-2299718", "REACTOME:R-HSA-2299718", "REACTOME:R-MMU-2299718" ]

3

[ "9f5w" ]

1

[ "PUB00056240" ]

[ "14532007" ]

[ "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2265 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 2, 5, 1, 4, 4, 3 ]

8

true

Family

Condensin-2 complex subunit G2

Condensin2_G2

9

IPR024743

24,743

Dynein heavy chain, coiled coil stalk

Dynein_HC_stalk

Domain

31,481

false

The 380kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380kDa motor unit contains a concatenated chain of six AAA modules (D1-6), of which four correspond to the ATP binding sites with P-loop signatures, and two are modules in which the P loop has been lost in evolution. Thi...

[]

0

[ "PFAM" ]

[ "PF12777" ]

[ "MT" ]

[ 31481 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-5620924", "R-CEL-6798695", "R-CEL-6807878", "R-CEL-6811436", "R-CEL-9646399", "R-DDI-6798695", "R-DDI-6807878", "R-DDI-9646399", "R-DME-3371497", "R-DME-6798695", "R-DME-6807878", "R-DME-6811436", "R-DME-9646399", "R-HSA-141444", "R-HSA-2132295", "R-HSA-2467813", "R-HSA-250025...

[ "REACTOME:R-CEL-5620924", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811436", "REACTOME:R-CEL-9646399", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-9646399", "REACTOME:R-DME-3371497", "REACTOME:R-DME-6798695", "REACTOME:R-DME-6807878", "REACTOM...

82

[ "2rr7", "3err", "3j1t", "3j1u", "3j6p", "3vkg", "3vkh", "3wuq", "4rh7", "5ayh", "5nug", "6kio", "6kiq", "6kjn", "6kjo", "6l4p", "6rla", "6rlb", "6rza", "6rzb", "6sc2", "6zyw", "6zyx", "6zyy", "7k58", "7k5b", "7kek", "7kzm", "7kzn", "7kzo", "7mgm", "7moq"...

152

[ "PUB00028625", "PUB00061850", "PUB00062447", "PUB00163363", "PUB00163364" ]

[ "11250194", "8666668", "22398446", "16061793", "16229832" ]

[ "Model for the motor component of dynein heavy chain based on homology to the AAA family of oligomeric ATPases.", "Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.", "The 2.8 A crystal structure of the dynein motor domain.", "Cilia and Hedgehog...

[ 2001, 1996, 2012, 2005, 2005 ]

5

[]

0

null

[ "Eukaryota", "mine drainage metagenome" ]

[ 31480, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 4, 33, 31, 61, 36, 1, 57, 1, 1 ]

9

true

Domain

Dynein heavy chain, coiled coil stalk

Dynein_HC_stalk

2

IPR024744

24,744

Putative cyclic diguanylate phosphodiesterase, CSS motif-containing domain

CSS-motif_dom

Domain

9,735

false

This domain, with its characteristic highly conserved CSS sequence motif, is found N-terminal to the EAL domain ( ), found in many putative cyclic diguanylate phosphodiesterases, such as PdeB/C/D/G/N from E. coli K-12 [ ]. It has two highly conserved cysteine residues with potential disulfide bonds formation which migh...

[]

0

[ "PFAM" ]

[ "PF12792" ]

[ "CSS-motif" ]

[ 9735 ]

1

[ "EC" ]

[ "3.1.4.52" ]

[ "EC:3.1.4.52" ]

1

[]

0

[ "PUB00100659" ]

[ "29514851" ]

[ "Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 9691, 8, 36 ]

3

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

Putative cyclic diguanylate phosphodiesterase, CSS motif-containing domain

CSS-motif_dom

5

IPR024745

24,745

Glycoside hydrolase, family 44, catalytic domain

GH44_cat

Domain

810

false

This is the catalytic domain of a family of bacterial glycoside hydrolases formerly known as cellulase family J, and now known as Cel44A. It is one of the major enzymatic components of the cellulosome of Clostridium thermocellum strain F1 [ ] and of many other Firmicutes.

[]

0

[ "PFAM" ]

[ "PF12891" ]

[ "Glyco_hydro_44" ]

[ 810 ]

1

[]

0

[ "2e0p", "2e4t", "2eex", "2ej1", "2eo7", "2eqd", "2yih", "2yjq", "2ykk", "3fw6", "3ii1", "3ik2", "3zq9" ]

13

[ "PUB00052649" ]

[ "17905739" ]

[ "Crystal structure of Cel44A, a glycoside hydrolase family 44 endoglucanase from Clostridium thermocellum." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 663, 140, 7 ]

3

[]

0

true

Domain

Glycoside hydrolase, family 44, catalytic domain

GH44_cat

1

IPR024746

24,746

Glycosyl hydrolase family 100

Glyco_hydro_100

Family

6,229

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0033926" ]

[ "endo-alpha-N-acetylgalactosaminidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF12899", "PTHR31916" ]

[ "Glyco_hydro_100", "" ]

[ 6224, 5730 ]

2

[ "EC", "GP", "METACYC" ]

[ "3.2.1.26", "GenProp1492", "PWY-8314" ]

[ "EC:3.2.1.26", "GP:GenProp1492", "METACYC:PWY-8314" ]

3

[ "5goo", "5gop", "5goq", "5gor", "5z73", "5z74", "6ttj" ]

7

[ "PUB00004870", "PUB00005266", "PUB00019747", "PUB00057451" ]

[ "7624375", "8535779", "8972597", "10482654" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Purification and characterization of neutral and alkaline invertase from carrot.", "Invertases. Primary structures, functions, and roles in pl...

[ 1995, 1995, 1996, 1999 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Streptophyta", "ecological metagenomes" ]

[ 5, 804, 5417, 3 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 38, 26, 52 ]

3

true

Family

Glycosyl hydrolase family 100

Glyco_hydro_100

1

IPR024747

24,747

Pyridoxamine 5'-phosphate oxidase-related

Pyridox_Oxase-rel

Family

20,408

false

Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several uncharacterised proteins, some annotated as pyridoxamine 5'-phosphate oxidase-related.

[]

0

[ "PFAM" ]

[ "PF12900" ]

[ "Pyridox_ox_2" ]

[ 20408 ]

1

[]

0

[ "1w3o", "1w3p", "1w3q", "1w3r", "2fg9", "2fur", "2hq9", "2hti", "2vpa", "2x1j", "2x1k", "3cp3", "3fkh", "3u0i", "3u5w", "4ybn", "6eci", "6rk0" ]

18

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1464, 17082, 1604, 258 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Pyridoxamine 5'-phosphate oxidase-related

Pyridox_Oxase-rel

7

IPR024749

24,749

Putative collagen-binding domain

Collagen-bd_put

Domain

2,286

false

This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. The structure of one family member, , has been characterised. The domain occurs in the C-terminal region of the protein.

[]

0

[ "PFAM" ]

[ "PF12904" ]

[ "Collagen_bind_2" ]

[ 2286 ]

1

[]

0

[ "3kzs", "4qfu", "5msy", "8t9w" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 4, 1970, 297, 15 ]

4

[]

0

true

Domain

Putative collagen-binding domain

Collagen-bd_put

8

IPR024750

24,750

Calcium-transporting P-type ATPase, N-terminal autoinhibitory domain

Ca_ATPase_N_dom

Domain

4,830

false

This entry represents the N-terminal autoinhibitory calmodulin-binding domain characteristic of certain calcium-transporting ATPases [ ]. This domain binds calmodulin in a calcium-dependent fashion and has a conserved RRFR sequence motif. There are two completely conserved residues (F and W) that may be functionally im...

[ "GO:0005516" ]

[ "calmodulin binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12515" ]

[ "CaATP_NAI" ]

[ 4830 ]

1

[ "EC" ]

[ "7.2.2.10" ]

[ "EC:7.2.2.10" ]

1

[ "2l1w", "2m73", "2m7e", "4aqr", "8qmp" ]

5

[ "PUB00056248" ]

[ "9422775" ]

[ "A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4830 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 21, 75 ]

3

true

Domain

Calcium-transporting P-type ATPase, N-terminal autoinhibitory domain

Ca_ATPase_N_dom

1

IPR024751

24,751

Variant erythrocyte surface antigen-1

VESA1

Family

641

false

This entry represents variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation ...

[]

0

[ "PFAM" ]

[ "PF12785" ]

[ "VESA1_N" ]

[ 641 ]

1

[]

0

[]

0

[ "PUB00056249" ]

[ "16390438" ]

[ "Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription." ]

[ 2006 ]

1

[]

0

null

[ "Babesia" ]

[ 641 ]

1

[]

0

true

Family

Variant erythrocyte surface antigen-1

VESA1

4

IPR024752

24,752

Myb/SANT-like domain

Myb/SANT-like_dom

Domain

21,325

false

This domain, found in L10-interacting MYB domain-containing protein (LIMYB) and At2g29880 from Arabidopsis, is related to Myb/SANT-like DNA binding domains. LIMYB is a transcription factor that associates with ribosomal protein promoters. It is involved in global translation suppression as an antiviral immunity strateg...

[]

0

[ "PFAM" ]

[ "PF12776" ]

[ "Myb_DNA-bind_3" ]

[ 21325 ]

1

[]

0

[]

0

[ "PUB00097743" ]

[ "25707794" ]

[ "NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 21325 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 73, 1, 207, 314 ]

4

true

Domain

Myb/SANT-like domain

Myb/SANT-like_dom

5

IPR024753

24,753

Regulatory protein AriR

AriR

Family

1,752

false

AriR, also known as YmgB, is part of the three gene cluster ymgABC which has a role in biofilm development and stability. YmgB represses biofilm formation in rich medium containing glucose, decreases cellular motility and also protects the cell from acid, which indicates that YmgB has an important function in acid-resi...

[ "GO:0071468" ]

[ "cellular response to acidic pH" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10798" ]

[ "YmgB" ]

[ 1752 ]

1

[]

0

[ "2oxl" ]

1

[ "PUB00048568" ]

[ "17765265" ]

[ "Structure and function of the Escherichia coli protein YmgB: a protein critical for biofilm formation and acid-resistance." ]

[ 2007 ]

1

[]

0

null

[ "Gammaproteobacteria", "Opisthokonta", "metagenomes" ]

[ 1747, 3, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Regulatory protein AriR

AriR

6

IPR024754

24,754

DNA polymerase III PolC-like, N-terminal domain II

DNA_PolC-like_N_II

Domain

3,974

false

This entry represents the second N-terminal domain, NII domain, of the DNA polymerase III PolC subunit A. DNA polymerase PolC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria [ ]. It has been predicted that the N terminus of PolC folds into two globular domains, NI and NII. A predicted h...

[]

0

[ "PFAM" ]

[ "PF11490" ]

[ "DNA_pol3_a_NII" ]

[ 3974 ]

1

[ "EC" ]

[ "2.7.7.7" ]

[ "EC:2.7.7.7" ]

1

[ "9qpc", "9qrl", "9qrn" ]

3

[ "PUB00056250", "PUB00066708" ]

[ "10048037", "21740522" ]

[ "A 'gram-negative-type' DNA polymerase III is essential for replication of the linear chromosome of Streptomyces coelicolor A3(2).", "The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III τ subunit." ]

[ 1999, 2011 ]

2

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 3969, 1, 4 ]

3

[]

0

true

Domain

DNA polymerase III PolC-like, N-terminal domain II

DNA_PolC-like_N_II

6

IPR024755

24,755

Circularly permutated YpsA SLOG

cpYpsA

Family

808

false

The structure of proteins in this family contain central β strands with flanking α helices. The structure is similar to that of a molybdenum cofactor carrier protein. This family belongs in the SLOG superfamily, circularly-permuted version of YspA famiy showing fusions to NAD utilization and ADP-ribosylation domains in...

[]

0

[ "PFAM" ]

[ "PF12694" ]

[ "cpYpsA" ]

[ 808 ]

1

[]

0

[ "3imk" ]

1

[ "PUB00091021" ]

[ "26590262" ]

[ "Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 572, 191, 8, 37 ]

4

[]

0

true

Family

Circularly permutated YpsA SLOG

cpYpsA

1

IPR024756

24,756

Protocatechuate 3,4-dioxygenase beta subunit, N-terminal

PCDO_beta_N

Domain

5,498

false

This entry represents the N-terminal domain of the beta subunit of protocatechuate 3,4-dioxidase. Protocatechuate 3,4-dioxidase utilises a mononuclear, non-heme Fe3+ centre to catalyse metabolic cellular reactions [ ]. This domain is found in bacteria, and is approximately 40 amino acids in length. It is found in assoc...

[]

0

[ "PFAM" ]

[ "PF12391" ]

[ "PCDO_beta_N" ]

[ 5498 ]

1

[ "EC", "METACYC" ]

[ "1.13.11.3", "PWY-6041" ]

[ "EC:1.13.11.3", "METACYC:PWY-6041" ]

2

[ "1eo2", "1eo9", "1eoa", "1eob", "1eoc", "1ykk", "1ykl", "1ykm", "1ykn", "1yko", "1ykp", "2bum", "2buq", "2bur", "2but", "2buu", "2buv", "2buw", "2bux", "2buy", "2buz", "2bv0", "2pcd", "3lkt", "3lmx", "3lxv", "3mfl", "3mi1", "3mi5", "3mv4", "3mv6", "3pca"...

52

[ "PUB00032987" ]

[ "9298971" ]

[ "Crystal structure and resonance Raman studies of protocatechuate 3,4-dioxygenase complexed with 3,4-dihydroxyphenylacetate." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5483, 3, 12 ]

3

[]

0

true

Domain

Protocatechuate 3,4-dioxygenase beta subunit, N-terminal

PCDO_beta_N

8

IPR024758

24,758

Inheritance of peroxisomes protein 1

Inp1

Family

1,142

false

Inp1 is a peroxisomal membrane protein that binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division [ ]. Inp1p promotes the retention of perox...

[ "GO:0045033", "GO:0005780" ]

[ "peroxisome inheritance", "extrinsic component of intraperoxisomal membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PRINTS" ]

[ "PF12634", "PR02103" ]

[ "Inp1", "INPROXISOME1" ]

[ 1137, 64 ]

2

[]

0

[]

0

[ "PUB00056252", "PUB00056253" ]

[ "15928207", "17506702" ]

[ "Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae.", "Maintaining peroxisome populations: a story of division and inheritance." ]

[ 2005, 2007 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1142 ]

1

[ "Caenorhabditis elegans", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1, 1 ]

3

true

Family

Inheritance of peroxisomes protein 1

Inp1

8

IPR024759

24,759

UvrB, YAD/RRR-motif-containing domain

UvrB_YAD/RRR_dom

Domain

27,133

false

This entry represents a domain found towards the C terminus of the ultraviolet resistance protein B (UvrB). UvrB conveys mutational resistance against UV light to various different species [ ]. This domain is approximately 40 amino acids in length and contains two conserved sequence motifs: YAD and RRR.

[]

0

[ "PFAM" ]

[ "PF12344" ]

[ "UvrB" ]

[ 27133 ]

1

[]

0

[ "1c4o", "1d2m", "1d9x", "1d9z", "1t5l", "2d7d", "2fdc", "2nmv", "3uwx", "3v4r", "6o8e", "6o8f", "6o8g", "6o8h", "9ga3", "9ga4" ]

16

[ "PUB00056276" ]

[ "7721686" ]

[ "A promoter associated with the neisserial repeat can be used to transcribe the uvrB gene from Neisseria gonorrhoeae." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctXQ92", "unclassified sequences" ]

[ 611, 25779, 165, 1, 577 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

UvrB, YAD/RRR-motif-containing domain

UvrB_YAD/RRR_dom

4

IPR024760

24,760

Helix-turn-helix, conjugative transposon-like

HTH_dom_conjug_TS-like

Domain

3,150

false

This domain appears to be a helix-turn-helix domain, suggesting a transcriptional regulatory protein. Some proteins with this domain are annotated as conjugative transposon proteins.

[]

0

[ "PFAM" ]

[ "PF12645" ]

[ "HTH_16" ]

[ 3150 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 3117, 7, 26 ]

3

[]

0

true

Domain

Helix-turn-helix, conjugative transposon-like

HTH_dom_conjug_TS-like

6

IPR024761

24,761

Transcription factor IIIC, 90kDa subunit, N-terminal

TFIIIC_delta_N

Domain

3,494

false

This entry represents a domain found towards the N terminus of the 90kDa subunit of transcription factor IIIC (also known as subunit 9 in yeast [ ]). The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8 [ ].

[]

0

[ "PFAM" ]

[ "PF12657" ]

[ "TFIIIC_delta" ]

[ 3494 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061", "R-MMU-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-SPO-76061", "REACTOME:R-SPO-76066" ]

7

[ "8cli", "8clj", "8cll" ]

3

[ "PUB00056254", "PUB00056255" ]

[ "10523658", "11433012" ]

[ "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.", "Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human." ]

[ 1999, 2001 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3494 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 9, 2, 3, 5, 1, 4, 1, 7 ]

8

true

Domain

Transcription factor IIIC, 90kDa subunit, N-terminal

TFIIIC_delta_N

3

IPR024763

24,763

Vacuolar protein sorting protein 11, C-terminal

VPS11_C

Domain

3,821

false

This entry represents the C-terminal domain of vps11 and its orthologues in Saccharomyces cerevisiae known as E3 ubiquitin-protein ligase PEP5. It also represents RING finger protein PFE0100w found in Plasmodium falciparum, a malaria-causing parasite. Vacuolar protein sorting protein 11 (vps11) aggregates with other Vp...

[]

0

[ "PFAM" ]

[ "PF12451" ]

[ "VPS11_C" ]

[ 3821 ]

1

[ "REACTOME" ]

[ "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9754560" ]

1

[ "7zu0", "8qx8" ]

2

[ "PUB00073489", "PUB00155784" ]

[ "22570702", "33452836" ]

[ "Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.", "A Novel Homozygous VPS11 Variant May Cause Generalized Dystonia." ]

[ 2012, 2021 ]

2

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 3820, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Z...

[ 4, 1, 2, 5, 2, 1, 3, 3, 1, 3 ]

10

true

Domain

Vacuolar protein sorting protein 11, C-terminal

VPS11_C

8

IPR024764

24,764

Transcription factor IIIC, putative zinc-finger

TFIIIC_Znf

Domain

2,597

false

This zinc-finger domain is at the very C terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions [ ].

[]

0

[ "PFAM" ]

[ "PF12660" ]

[ "zf-TFIIIC" ]

[ 2597 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061", "R-MMU-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-SPO-76061", "REACTOME:R-SPO-76066" ]

7

[ "2j04", "8cli", "8clj", "8cll", "8ffz", "9gc3" ]

6

[ "PUB00056254" ]

[ "10523658" ]

[ "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2597 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 2, 2, 5, 1, 2, 1, 1, 26 ]

8

true

Domain

Transcription factor IIIC, putative zinc-finger

TFIIIC_Znf

4

IPR024765

24,765

TOBE-like domain

TOBE-like

Domain

5,215

false

The TOBE (transport-associated OB) domain [ ] always occurs as a dimer and it is found in ABC transporters immediately after the ATPase domain. This entry represents a TOBE-like domain, found in the C terminus of ATPase subunit CysA. CysA is part of the CysATWP ABC transporter complex, involved in sulphate/thiosulphate...

[]

0

[ "PFAM" ]

[ "PF12857" ]

[ "TOBE_3" ]

[ 5215 ]

1

[ "EC", "REACTOME" ]

[ "7.3.2.3", "R-MTU-936635" ]

[ "EC:7.3.2.3", "REACTOME:R-MTU-936635" ]

2

[]

0

[ "PUB00007673", "PUB00035343", "PUB00035345" ]

[ "10829230", "2188958", "15893314" ]

[ "Protein fold recognition using sequence profiles and its application in structural genomics.", "Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster.", "Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) ...

[ 2000, 1990, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5191, 3, 21 ]

3

[]

0

true

Domain

TOBE-like domain

TOBE-like

6

IPR024766

24,766

Zinc finger, RING-H2-type

Znf_RING_H2

Domain

9,930

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12678" ]

[ "zf-rbx1" ]

[ 9930 ]

1

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp1311", "GenProp1754", "R-CEL-110314", "R-CEL-1234176", "R-CEL-195253", "R-CEL-4641258", "R-CEL-5632684", "R-CEL-5696394", "R-CEL-5696395", "R-CEL-5696400", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-68949", "R-CEL-69601", "R-CEL-8854050", "R-CEL-8939902", "R-...

[ "GP:GenProp1311", "GP:GenProp1754", "REACTOME:R-CEL-110314", "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-5696394", "REACTOME:R-CEL-5696395", "REACTOME:R-CEL-5696400", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", ...

147

[ "1ldj", "1ldk", "1u6g", "2ecl", "2hye", "2lgv", "3dpl", "3dqv", "3rtr", "4a0c", "4a0k", "4a0l", "4f52", "4p5o", "5n4w", "6r6h", "6r7f", "6r7h", "6r7i", "6r7n", "6ttu", "6v9i", "7b5l", "7b5m", "7b5n", "7b5s", "7okq", "7oni", "7opc", "7opd", "7plo", "7shk"...

93

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00056256" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "14622138" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 2003 ]

7

[ "IPR001841" ]

[]

1

0

1

[ "Allofrancisella guangzhouensis", "Eukaryota", "Viruses", "metagenomes" ]

[ 1, 9881, 27, 21 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 16, 2, 2, 5, 3, 5, 11, 5, 2, 3, 35 ]

11

true

Domain

Zinc finger, RING-H2-type

Znf_RING_H2

2

IPR024770

24,770

TcdA/TcdB toxin, catalytic glycosyltransferase domain

TcdA/TcdB_cat

Domain

643

false

Toxins A (TcdA) and B (TcdB) of Clostridium difficile belong to the family of clostridial glucosylating toxins. These toxins glucosylate small GTPases of Rho and Ras families, inhibiting the signalling and regulatory functions of these switch proteins. After receptor-binding, the toxins are endocytosed to reach acidic ...

[ "GO:0016757" ]

[ "glycosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12919" ]

[ "TcdA_TcdB" ]

[ 643 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.4.1.-", "3.4.22.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313...

[ "EC:2.4.1.-", "EC:3.4.22.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139",...

201

[ "2bvl", "2bvm", "2vk9", "2vkd", "2vkh", "2vl8", "3srz", "3ss1", "4dmv", "4dmw", "4r04", "5uqk", "5uql", "5uqm", "5uqn", "5uqt", "5vqm", "6ar6", "6oq5", "6oq7", "6oq8", "6rtg", "6rth", "7lou", "7lov", "7ml7", "7n8x", "7n95", "7n97", "7n9q", "7n9r", "7n9s"...

60

[ "PUB00039778", "PUB00056259", "PUB00056260" ]

[ "16054646", "21231971", "20498856" ]

[ "Structural basis for the function of Clostridium difficile toxin B.", "Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.", "Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis." ]

[ 2005, 2011, 2010 ]

3

[]

0

null

[ "Alveolata", "Bacteria" ]

[ 7, 636 ]

2

[]

0

true

Domain

TcdA/TcdB toxin, catalytic glycosyltransferase domain

TcdA/TcdB_cat

7

IPR024771

24,771

SUZ domain

SUZ

Domain

13,992

false

The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterised in the Caenorhabditis elegans protein SZY-20 where it has been shown to bind RNA and allow their localization to the centrosome [ ].

[]

0

[ "PFAM", "PROFILE" ]

[ "PF12752", "PS51673" ]

[ "SUZ", "SUZ" ]

[ 12122, 13722 ]

2

[]

0

[]

0

[ "PUB00056085" ]

[ "19081077" ]

[ "The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 13992 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 4, 75, 6, 18, 15, 2, 11, 27, 48 ]

10

true

Domain

SUZ domain

SUZ

5

IPR024772

24,772

TcdA/TcdB toxin, N-terminal helical domain

TcdA/TcdB_N

Domain

217

false

Toxins A (TcdA) and B (TcdB) of Clostridium difficile belong to the family of clostridial glucosylating toxins. These toxins glucosylate small GTPases of Rho and Ras families, inhibiting the signalling and regulatory functions of these switch proteins. After receptor-binding, the toxins are endocytosed to reach acidic ...

[]

0

[ "PFAM" ]

[ "PF12918" ]

[ "TcdB_N" ]

[ 217 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.4.1.-", "3.4.22.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313...

[ "EC:2.4.1.-", "EC:3.4.22.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139",...

201

[ "2bvl", "2bvm", "2vk9", "2vkd", "2vkh", "2vl8", "3srz", "3ss1", "4dmv", "4dmw", "4r04", "5uqk", "5uql", "5uqm", "5uqn", "5uqt", "5vqm", "6ar6", "6oq5", "6oq7", "6oq8", "7lou", "7lov", "7ml7", "7n95", "7n97", "7n9q", "7n9r", "7n9s", "7n9y", "7pog", "7s0y"...

57

[ "PUB00039778", "PUB00056259", "PUB00056260" ]

[ "16054646", "21231971", "20498856" ]

[ "Structural basis for the function of Clostridium difficile toxin B.", "Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.", "Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis." ]

[ 2005, 2011, 2010 ]

3

[]

0

null

[ "Bacteria" ]

[ 217 ]

1

[]

0

true

Domain

TcdA/TcdB toxin, N-terminal helical domain

TcdA/TcdB_N

5

IPR024774

24,774

Pleckstrin homology domain, Mcp5-type

PH_dom-Mcp5-type

Domain

3,095

false

This pleckstrin homology domain is found in eukaryotic proteins, including Mcp5, a fungal protein that anchors dynein at the cell cortex during the horsetail phase (prophase I) of meiosis. During prophase I of fission yeast all the telomeres become bundled at the spindle pole body and subsequently the nucleus undergoes...

[ "GO:0005515", "GO:0005543", "GO:0032065", "GO:0005938" ]

[ "protein binding", "phospholipid binding", "maintenance of protein location in cell cortex", "cell cortex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF12814" ]

[ "Mcp5_PH" ]

[ 3095 ]

1

[]

0

[]

0

[ "PUB00056261" ]

[ "16585273" ]

[ "Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast." ]

[ 2006 ]

1

[ "IPR001849" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3095 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Domain

Pleckstrin homology domain, Mcp5-type

PH_dom-Mcp5-type

2

IPR024775

24,775

Hercynine oxygenase, DinB-like domain

EgtB_DinB-like

Domain

42,364

false

This entry represents a DinB-like structural domain found in Hercynine oxygenase (egtB), putative metal-dependent hydrolase and related proteins. DinB from Bacillus subtilis and related Gram-positive bacteria is a DNA-damage-induced gene and the corresponding protein contains a four helix bundle. This fold is shared by...

[]

0

[ "PFAM" ]

[ "PF12867" ]

[ "DinB_2" ]

[ 42364 ]

1

[]

0

[ "1rxq", "2hkv", "2qnl", "2rd9", "2yqy", "3cex", "4x8b", "4x8d", "4x8e", "5wk0", "6o6l", "6o6m", "6qki", "6qkj", "8k5i", "8k5j", "8k5k", "8khq", "8qf6", "8ryz", "8u41", "8u42", "8ux5" ]

23

[ "PUB00056262", "PUB00060032" ]

[ "20208147", "20420449" ]

[ "The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily.", "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis." ]

[ 2010, 2010 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Paenibacillus phage phiBP", "unclassified sequences" ]

[ 64, 40140, 1705, 1, 454 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Domain

Hercynine oxygenase, DinB-like domain

EgtB_DinB-like

3

IPR024778

24,778

Putative cellulase

Put_cellulase

Family

408

false

This entry represents a family of putative cellulase enzymes. The structure is a TIM-barrel.

[]

0

[ "PFAM" ]

[ "PF12876" ]

[ "Cellulase-like" ]

[ 408 ]

1

[]

0

[ "3gyc" ]

1

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "bioreactor metagenome" ]

[ 401, 6, 1 ]

3

[]

0

true

Family

Putative cellulase

Put_cellulase

1

IPR024779

24,779

2OGFeDO JBP1/TET, oxygenase domain

2OGFeDO_JBP1/TET_oxygenase_dom

Domain

4,559

false

This entry represents the catalytic domain from nucleic-acid modifying members of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily [ ]. These proteins catalyse nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids [ ], and the conversion of 5 me...

[]

0

[ "PFAM" ]

[ "PF12851" ]

[ "Tet_JBP" ]

[ 4559 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11.6", "R-HSA-5221030", "R-HSA-9821002", "R-HSA-9827857" ]

[ "EC:1.14.11.6", "REACTOME:R-HSA-5221030", "REACTOME:R-HSA-9821002", "REACTOME:R-HSA-9827857" ]

4

[ "4nm6", "5d9y", "5deu", "7ne3", "7ne6", "7vpn", "7w5p", "8jkk", "9hxv" ]

9

[ "PUB00056275", "PUB00056277", "PUB00057265", "PUB00057266", "PUB00057267", "PUB00099119" ]

[ "19372391", "21057493", "19411852", "20215442", "21817016", "24315485" ]

[ "Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.", "Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.", "Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids.", "Two...

[ 2009, 2010, 2009, 2010, 2011, 2013 ]

6

[]

[ "IPR046942" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 14, 4467, 18, 60 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 1, 7, 13, 12 ]

5

true

Domain

2OGFeDO JBP1/TET, oxygenase domain

2OGFeDO_JBP1/TET_oxygenase_dom

3

IPR024781

24,781

Merozoite surface protein, C-terminal

MSP_C

Domain

1,096

false

Merozoite surface protein 7 (MSP7) is a protein of the malaria parasite that has been found to be associated with processed fragments from the MSP1 protein in a complex involved in red blood cell invasion [ ]. This entry represents a C-terminal domain found in MSP7 and other Plasmodium merozoite surface proteins.

[]

0

[ "PFAM" ]

[ "PF12948" ]

[ "MSP7_C" ]

[ 1096 ]

1

[]

0

[]

0

[ "PUB00056263" ]

[ "11551634" ]

[ "The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7." ]

[ 2001 ]

1

[]

0

null

[ "Plasmodium" ]

[ 1096 ]

1

[]

0

true

Domain

Merozoite surface protein, C-terminal

MSP_C

3

IPR024783

24,783

Transducer of regulated CREB activity, N-terminal

TORC_N

Domain

3,343

false

This entry represents the N-terminal domain of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Elem...

[ "GO:0008140", "GO:0051289" ]

[ "cAMP response element binding protein binding", "protein homotetramerization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF12884" ]

[ "TORC_N" ]

[ 3343 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2151201", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-9931510" ]

[ "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9707616", "REACTOME:R-HSA-9931509", "REACTOME:R-HSA-9931510" ]

4

[ "4htm", "5zk1", "5zko" ]

3

[ "PUB00056264", "PUB00056265", "PUB00056266" ]

[ "14536081", "14506290", "17565599" ]

[ "TORCs: transducers of regulated CREB activity.", "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.", "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain." ]

[ 2003, 2003, 2007 ]

3

[]

0

null

[ "Metazoa" ]

[ 3343 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 24, 2, 8, 3, 10 ]

6

true

Domain

Transducer of regulated CREB activity, N-terminal

TORC_N

7

IPR024784

24,784

Transducer of regulated CREB activity, middle domain

TORC_M

Domain

3,717

false

This domain represents the region between the N and C terminus of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB ...

[]

0

[ "PFAM" ]

[ "PF12885" ]

[ "TORC_M" ]

[ 3717 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2151201", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-9931510" ]

[ "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9707616", "REACTOME:R-HSA-9931509", "REACTOME:R-HSA-9931510" ]

4

[]

0

[ "PUB00056264", "PUB00056265" ]

[ "14536081", "14506290" ]

[ "TORCs: transducers of regulated CREB activity.", "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 3717 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 30, 10, 7, 11 ]

4

true

Domain

Transducer of regulated CREB activity, middle domain

TORC_M

3

IPR024785

24,785

Transducer of regulated CREB activity, C-terminal

TORC_C

Domain

3,507

false

This entry represents the C-terminal domain of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Elem...

[]

0

[ "PFAM" ]

[ "PF12886" ]

[ "TORC_C" ]

[ 3507 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2151201", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-9931510" ]

[ "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9707616", "REACTOME:R-HSA-9931509", "REACTOME:R-HSA-9931510" ]

4

[]

0

[ "PUB00056264", "PUB00056265" ]

[ "14536081", "14506290" ]

[ "TORCs: transducers of regulated CREB activity.", "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 3507 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 29, 8, 6, 11 ]

4

true

Domain

Transducer of regulated CREB activity, C-terminal

TORC_C

5

IPR024787

24,787

EcsC protein

EcsC

Family

7,140

false

Proteins in this family are related to EcsC from Bacillus subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system [ ]. The function of this protein is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF12787", "PTHR41260" ]

[ "EcsC", "" ]

[ 7136, 5905 ]

2

[]

0

[]

0

[ "PUB00011939" ]

[ "8581172" ]

[ "Molecular analysis of an operon in Bacillus subtilis encoding a novel ABC transporter with a role in exoprotein production, sporulation and competence." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7093, 10, 37 ]

3

[]

0

true

Family

EcsC protein

EcsC

3

IPR024788

24,788

Malectin-like domain

Malectin-like_Carb-bd_dom

Domain

26,305

false

Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan [ ]. The domain is found on a number of plant receptor kinases and is distantly related to malectin domains.

[]

0

[ "PFAM" ]

[ "PF12819" ]

[ "Malectin_like" ]

[ 26305 ]

1

[ "EC" ]

[ "2.7.11.1" ]

[ "EC:2.7.11.1" ]

1

[ "5y92", "5y96", "6a5a", "6a5b", "6a5c", "6a5e", "6fig", "6fih" ]

8

[ "PUB00048116" ]

[ "18524852" ]

[ "Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Streptophytina" ]

[ 2, 26303 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 410, 200, 127 ]

3

true

Domain

Malectin-like domain

Malectin-like_Carb-bd_dom

4

IPR024789

24,789

Anaphase-promoting complex subunit 4

APC4

Family

4,788

false

The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, there...

[ "GO:0031145", "GO:0005680" ]

[ "anaphase-promoting complex-dependent catabolic process", "anaphase-promoting complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR13260" ]

[ "" ]

[ 4788 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-983168", "R-DDI-141430", "R-DDI-174048", "R-DDI-174084", "R-DDI-174154", "R-DDI-174178", "R-DDI-174184", "R-DDI-176407", "R-DDI-176408", "R-DDI-176409", "R-DDI-176412", "R-DDI-179409", "R-DDI-2467813", "R-DDI-2559582", "R-DDI-69017", "R-DDI-983168", "R-HSA-141430", "R-HSA-17...

[ "REACTOME:R-CEL-983168", "REACTOME:R-DDI-141430", "REACTOME:R-DDI-174048", "REACTOME:R-DDI-174084", "REACTOME:R-DDI-174154", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-174184", "REACTOME:R-DDI-176407", "REACTOME:R-DDI-176408", "REACTOME:R-DDI-176409", "REACTOME:R-DDI-176412", "REACTOME:R-DDI-179...

52

[ "4ui9", "5a31", "5bpt", "5bpw", "5g04", "5g05", "5khr", "5khu", "5l9t", "5l9u", "5lcw", "6q6g", "6q6h", "6tlj", "6tm5", "6tnt", "8a3t", "8a5y", "8a61", "8pkp", "8tar", "8tau", "9gaw", "9n9r", "9n9s" ]

25

[ "PUB00056270", "PUB00059221" ]

[ "10749938", "18485873" ]

[ "EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.", "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex." ]

[ 2000, 2008 ]

2

[]

[ "IPR017169" ]

0

1

0

[ "Alphaproteobacteria", "Eukaryota", "Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)" ]

[ 4, 4783, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 7, 3, 4, 7, 1, 4, 5, 1, 1, 31 ]

12

true

Family

Anaphase-promoting complex subunit 4

APC4

7

IPR024790

24,790

Anaphase-promoting complex subunit 4, long domain

APC4_long_dom

Domain

4,291

false

Apc4 is one of the larger of the subunits of the anaphase-promoting complex (APC) or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [ , ]. Results in Caenorhabditis elegans show that the primary...

[]

0

[ "PFAM" ]

[ "PF12896" ]

[ "ANAPC4" ]

[ 4291 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-141430", "R-DDI-174048", "R-DDI-174084", "R-DDI-174154", "R-DDI-174178", "R-DDI-174184", "R-DDI-176407", "R-DDI-176408", "R-DDI-176409", "R-DDI-176412", "R-DDI-179409", "R-DDI-2467813", "R-DDI-2559582", "R-DDI-69017", "R-DDI-983168", "R-HSA-141430", "R-HSA-174048", "R-HSA-17...

[ "REACTOME:R-DDI-141430", "REACTOME:R-DDI-174048", "REACTOME:R-DDI-174084", "REACTOME:R-DDI-174154", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-174184", "REACTOME:R-DDI-176407", "REACTOME:R-DDI-176408", "REACTOME:R-DDI-176409", "REACTOME:R-DDI-176412", "REACTOME:R-DDI-179409", "REACTOME:R-DDI-246...

51

[ "4ui9", "5a31", "5bpt", "5bpw", "5g04", "5g05", "5khr", "5khu", "5l9t", "5l9u", "5lcw", "6q6g", "6q6h", "6tlj", "6tm5", "6tnt", "8a3t", "8a5y", "8a61", "8pkp", "8tar", "8tau", "9gaw", "9n9r", "9n9s" ]

25

[ "PUB00055977", "PUB00056269", "PUB00056270" ]

[ "16896351", "12049731", "10749938" ]

[ "The anaphase promoting complex/cyclosome: a machine designed to destroy.", "The anaphase-promoting complex: proteolysis in mitosis and beyond.", "EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans." ]

[ 2006, 2002, 2000 ]

3

[]

0

null

[ "Eukaryota", "Pontibacter anaerobius" ]

[ 4290, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 7, 3, 2, 5, 1, 3, 5, 1, 1, 18 ]

11

true

Domain

Anaphase-promoting complex subunit 4, long domain

APC4_long_dom

4

IPR024792

24,792

Rho GDP-dissociation inhibitor domain superfamily

RhoGDI_dom_sf

Homologous_superfamily

8,065

false

The GDP dissociation inhibitor for rho proteins, rho GDI, regulates GDP/GTP exchange by inhibiting the dissociation of GDP from them. The protein contains 204 amino acids, with a calculated Mr value of 23,421. Hydropathy analysis shows it to be largely hydrophilic, with a single hydrophobic region. The protein plays an...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.70.50.30" ]

[ "" ]

[ 8065 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-9013148", "R-BTA-9013407", "R-BTA-9013408", "R-CEL-8980692", "R-CEL-9013026", "R-CEL-9013148", "R-CEL-9013149", "R-CEL-9013404", "R-CEL-9013407", "R-CEL-9013408", "R-CEL-9013423", "R-DDI-9013148", "R-DDI-9013149", "R-DDI-9013404", "R-DDI-9013407", "R-DDI-9013408", "R-DDI-90134...

[ "REACTOME:R-BTA-9013148", "REACTOME:R-BTA-9013407", "REACTOME:R-BTA-9013408", "REACTOME:R-CEL-8980692", "REACTOME:R-CEL-9013026", "REACTOME:R-CEL-9013148", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013404", "REACTOME:R-CEL-9013407", "REACTOME:R-CEL-9013408", "REACTOME:R-CEL-9013423", "REACTOM...

55

[ "1ajw", "1cc0", "1doa", "1ds6", "1fso", "1fst", "1ft0", "1ft3", "1gdf", "1hh4", "1kmt", "1qvy", "1rho", "2bxw", "2jhs", "2jht", "2jhu", "2jhv", "2jhw", "2jhx", "2jhy", "2jhz", "2ji0", "2n80", "4f38", "5fr1", "5fr2", "5h1d", "8x8t", "9x53", "9x54", "9x55"...

34

[ "PUB00001445", "PUB00003781", "PUB00021430", "PUB00030678", "PUB00101427", "PUB00101429", "PUB00101430" ]

[ "8223583", "8796870", "10655614", "9195882", "12198156", "9242378", "12163018" ]

[ "Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages.", "The NADPH oxidase and chronic granulomatous disease.", "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.", "A modulator...

[ 1993, 1996, 2000, 1997, 2002, 1997, 2002 ]

7

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 38, 8027 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 2, 1, 21, 7, 1, 11, 8, 1, 1, 23 ]

12

true

Homologous_superfamily

Rho GDP-dissociation inhibitor domain superfamily

RhoGDI_dom_sf

1

IPR024793

24,793

Thrombin inhibitor hirudin

Hirudin

Homologous_superfamily

40

false

Hirudin (MEROPS identifier I14.001) is a potent thrombin inhibitor secreted by the salivary glands of the Hirudinaria manillensis (buffalo leech) and Hirudo medicinalis (medicinal leech) [ ]. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. The structure o...

[ "GO:0004867" ]

[ "serine-type endopeptidase inhibitor activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:2.70.10.10" ]

[ "" ]

[ 40 ]

1

[]

0

[ "1e0f", "1hic", "1hrt", "2hir", "2joo", "2pw8", "3htc", "4hir", "4htc", "4mlf", "5hir", "6hir", "7a0d", "7a0e", "7a0f" ]

15

[ "PUB00000305", "PUB00004614", "PUB00005129" ]

[ "2567183", "3513162", "2374926" ]

[ "Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.", "Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.", "The structure of a ...

[ 1989, 1986, 1990 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 40 ]

1

[]

0

true

Homologous_superfamily

Thrombin inhibitor hirudin

Hirudin

8

IPR024794

24,794

Large ribosomal subunit protein eL15 core domain superfamily

Rbsml_eL15_core_dom_sf

Homologous_superfamily

7,026

false

A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities [ ]. One of these families consists of: Mammalian eL15. Insect eL15. Plant eL15y/z. Yeast eL15A/B. Archaebacterial eL15. These ribosomal proteins have a structure corresponding to a 3-layer (α-β-α) sandwic...

[ "GO:0003735", "GO:0005840" ]

[ "structural constituent of ribosome", "ribosome" ]

[ "molecular_function", "cellular_component" ]

2

[ "CATHGENE3D" ]

[ "G3DSA:3.40.1120.10" ]

[ "" ]

[ 7026 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

64

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

676

[ "PUB00000245" ]

[ "7733938" ]

[ "The Thermoplasma acidophilum rpl15 gene encodes a homologue of eukaryotic ribosomal proteins L15/YL10." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 920, 6, 6046, 54 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 12, 4, 1, 10, 7, 2, 2, 24 ]

12

true

Homologous_superfamily

Large ribosomal subunit protein eL15 core domain superfamily

Rbsml_eL15_core_dom_sf

7

IPR024796

24,796

T4 endonuclease V

T4_endonuc_V

Homologous_superfamily

642

false

The crystal structure of bacteriophage T4 endonuclease V reveals an enzyme composed of a single compact domain classified as an all-α structure [ ]. Pyrimidine dimer DNA glycosylases are enzymes responsible for initiating the base excision repair pathway, excising pyrimidine dimers by hydrolysis of the glycosylic bond ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.440.10" ]

[ "" ]

[ 642 ]

1

[]

0

[ "1eni", "1enj", "1enk", "1vas", "2end", "2fcc" ]

6

[ "PUB00007456", "PUB00015082", "PUB00036657" ]

[ "2067549", "11148051", "7783199" ]

[ "Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions.", "The reaction mechanism of DNA glycosylase/AP lyases at abasic sites.", "Crystal structure of a pyrimidine dimer-specific excision repair enzyme from bacteriophage T4: refinement at 1.45 ...

[ 1991, 2001, 1995 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Viruses", "metagenomes" ]

[ 73, 265, 297, 7 ]

4

[]

0

true

Homologous_superfamily

T4 endonuclease V

T4_endonuc_V

1

IPR024810

24,810

MAB21L/Cyclic GMP-AMP synthase-like receptor

MAB21L/cGLR

Family

14,989

false

This protein family includes Mab-21 and Mab-21-like (MAB21L) proteins, and the homologues cyclic GMP-AMP synthase-like receptors (cGLRs). MAB21L are putative nucleotidyltransferases required for several aspects of embryonic development including normal development of the eye [ , , , , ]. cGLRs are nucleotidyltransferas...

[]

0

[ "SMART" ]

[ "SM01265" ]

[ "Mab-21" ]

[ 14989 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1834941", "R-HSA-9937383", "R-MMU-9937383", "R-RNO-9937383" ]

[ "REACTOME:R-HSA-1834941", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-9937383" ]

4

[ "4jlx", "4jlz", "4k8v", "4k96", "4k97", "4k98", "4k99", "4k9a", "4k9b", "4kb6", "4km5", "4lev", "4lew", "4ley", "4lez", "4mkp", "4nxt", "4nxu", "4nxv", "4nxw", "4nxx", "4o67", "4o68", "4o69", "4o6a", "4oaf", "4oag", "4oah", "4oai", "4woy", "5eog", "5eom"...

185

[ "PUB00019829", "PUB00054288", "PUB00056602", "PUB00153376", "PUB00153377", "PUB00153378", "PUB00153379" ]

[ "8582275", "15385160", "16990268", "27103078", "27271801", "30487245", "37379839" ]

[ "The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates.", "Requirement for Mab21l2 during development of murine retina and ventral body wall.", "DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.", "Autosomal recessive ...

[ 1995, 2004, 2006, 2017, 2016, 2019, 2023 ]

7

[]

[ "IPR026250", "IPR045909" ]

0

2

0

[ "Clostridium moutaii", "Eukaryota", "Methanomicrobia" ]

[ 1, 14985, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 33, 9, 21, 17, 34 ]

6

true

Family

MAB21L/Cyclic GMP-AMP synthase-like receptor

MAB21L/cGLR

1

IPR024811

24,811

Polycomb protein ASX/ASX-like

ASX/ASX-like

Family

4,470

false

Polycomb group proteins are transcriptional repressors that control processes ranging from the maintenance of cell fate decisions and stem cell pluripotency in animals to the control of flowering time in plants. Additional sex combs (Asx) is a member of the polycomb group which is required for maintenance of stable rep...

[]

0

[ "PANTHER" ]

[ "PTHR13578" ]

[ "" ]

[ 4470 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5689603", "R-HSA-5689603", "R-MMU-5689603" ]

[ "REACTOME:R-DME-5689603", "REACTOME:R-HSA-5689603", "REACTOME:R-MMU-5689603" ]

3

[ "6cga", "6hgc", "8h1t", "8svf" ]

4

[ "PUB00056611", "PUB00056612" ]

[ "9477319", "20436459" ]

[ "The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.", "Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB." ]

[ 1998, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4470 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 5, 26, 15, 14 ]

5

true

Family

Polycomb protein ASX/ASX-like

ASX/ASX-like

2

IPR024812

24,812

Tetratricopeptide repeat protein 24

TPR_24

Family

998

false

This entry represents a family of tetratricopeptide repeat-containing proteins whose function is not currently known.

[]

0

[ "PANTHER" ]

[ "PTHR47050" ]

[ "" ]

[ 998 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus sibiricus (strain DSM 12597 / MM 739)", "ecological metagenomes" ]

[ 95, 893, 1, 9 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 22, 1, 2, 2 ]

4

true

Family

Tetratricopeptide repeat protein 24

TPR_24

9

IPR024822

24,822

Coilin

Family

2,425

false

Coilin is a nuclear phosphoprotein that serves as an assembly centre in Cajal bodies (CBs) and has a role in small nuclear ribonucleoprotein (snRNP) biogenesis, involved in the modification and assembly of nucleoplasmic snRNPs [ , ]. Coilin also acts to repress polymerase I activity in response to cisplatin-induced DNA...

[]

0

[ "PANTHER" ]

[ "PTHR15197" ]

[ "" ]

[ 2425 ]

1

[]

0

[]

0

[ "PUB00056623", "PUB00056626", "PUB00155892" ]

[ "21289084", "15862129", "7679389" ]

[ "Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.", "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.", "Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a...

[ 2011, 2005, 1993 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2425 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 1, 3, 6, 8, 22 ]

7

true

Family

Coilin

9

IPR024824

24,824

Growth arrest and DNA damage-inducible protein GADD45

GADD45

Family

3,865

false

The growth arrest and DNA damage GADD45 proteins, which include GADD45A, GADD45B , and GADD45G, are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation [ , , ]. GADD45 proteins interact with a number of other proteins implicated in s...

[ "GO:0051726", "GO:0005634" ]

[ "regulation of cell cycle", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR10411" ]

[ "" ]

[ 3865 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6804114", "R-HSA-6804114", "R-HSA-9617828", "R-MMU-6804114", "R-RNO-6804114" ]

[ "REACTOME:R-BTA-6804114", "REACTOME:R-HSA-6804114", "REACTOME:R-HSA-9617828", "REACTOME:R-MMU-6804114", "REACTOME:R-RNO-6804114" ]

5

[ "2kg4", "2wal", "3cg6", "3ffm" ]

4

[ "PUB00056627", "PUB00056628", "PUB00056629" ]

[ "1482047", "11960329", "7973727" ]

[ "Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest.", "Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation.", "Interaction of the p53-regulated protein Gadd45 with prol...

[ 1992, 2002, 1994 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 3865 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 12, 9, 8 ]

5

true

Family

Growth arrest and DNA damage-inducible protein GADD45

GADD45

5

IPR024825

24,825

Uroplakin-3a

Family

180

false

This entry represents uroplakin-3a. Defects in uroplakin-3a are a cause of renal adysplasia, a condition in which one or both kidneys are absent at birth [ , ]. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithel...

[]

0

[ "CDD" ]

[ "cd09970" ]

[ "UP_IIIa" ]

[ 180 ]

1

[]

0

[ "8jj5" ]

1

[ "PUB00056632", "PUB00056633", "PUB00080626", "PUB00080628", "PUB00084338", "PUB00084359" ]

[ "15888565", "16731295", "19340092", "17183244", "27729990", "7760330" ]

[ "De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure.", "Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans.", "Uroplakins in urothelial biology, function, and disease.", "Uroplakins: new molecular players in the biology of uri...

[ 2005, 2006, 2009, 2007, 2016, 1995 ]

6

[]

0

null

[ "Tetrapoda" ]

[ 180 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3 ]

3

true

Family

Uroplakin-3a

1

IPR024826

24,826

DNA polymerase delta/II small subunit family

DNA_pol_delta/II_ssu

Family

5,940

false

This entry represents the homologous small subunits from eukaryotic DNA polymerase delta and archaeal DNA polymerase II. The function of the small subunit is not known for either enzyme.

[]

0

[ "PANTHER" ]

[ "PTHR10416" ]

[ "" ]

[ 5940 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-BTA-110314", "R-BTA-174411", "R-BTA-174414", "R-BTA-174417", "R-BTA-174437", "R-BTA-5358565", "R-BTA-5358606", "R-BTA-5651801", "R-BTA-5656169", "R-BTA-5685942", "R-BTA-5696397", "R-BTA-5696400", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-69091", "R-BTA-69166", "R-BTA-6...

[ "EC:2.7.7.7", "REACTOME:R-BTA-110314", "REACTOME:R-BTA-174411", "REACTOME:R-BTA-174414", "REACTOME:R-BTA-174417", "REACTOME:R-BTA-174437", "REACTOME:R-BTA-5358565", "REACTOME:R-BTA-5358606", "REACTOME:R-BTA-5651801", "REACTOME:R-BTA-5656169", "REACTOME:R-BTA-5685942", "REACTOME:R-BTA-5696397",...

96

[ "3e0j", "5ihe", "6hmf", "6hms", "6knb", "6knc", "6p1h", "6s1m", "6s1n", "6s1o", "6t8h", "6tny", "6tnz", "6v8p", "6v93", "7kc0", "7lxd", "7s0t", "8ppt", "8ppu", "8ppv", "8tlq", "8tlt", "9ekb", "9f29", "9f2a" ]

26

[]

0

[]

[ "IPR011149" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 804, 5093, 43 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 17, 2, 1, 1, 8, 1, 1, 4 ]

12

true

Family

DNA polymerase delta/II small subunit family

DNA_pol_delta/II_ssu

1

IPR024829

24,829

Radiation-inducible immediate-early gene IEX-1

IEX-1

Family

820

false

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene. The protein is involved in cell proliferation and survival, including the protection of cells from TNF-induced apoptosis [ ]. It is rapidly induced by growth factors, viral infections or chemical carcinogens [ ]. IEX...

[ "GO:0043066" ]

[ "negative regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PRINTS", "PANTHER" ]

[ "PR02100", "PTHR16915" ]

[ "GENEIEX1", "" ]

[ 766, 443 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6811558", "R-MMU-6811558" ]

[ "REACTOME:R-HSA-6811558", "REACTOME:R-MMU-6811558" ]

2

[]

0

[ "PUB00056635", "PUB00056636", "PUB00056641", "PUB00056642" ]

[ "9703517", "12510147", "16456541", "12356731" ]

[ "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival.", "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis.", "B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.", "IEX-1: a new ERK substrate involv...

[ 1998, 2003, 2006, 2002 ]

4

[]

0

null

[ "Gnathostomata" ]

[ 820 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 1, 4 ]

4

true

Family

Radiation-inducible immediate-early gene IEX-1

IEX-1

4

IPR024831

24,831

Uroplakin-3

Family

1,865

false

This entry represents uroplakin-3 and related proteins. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet [ , ]. UPs are classified into 3 typ...

[]

0

[ "PANTHER" ]

[ "PTHR15446" ]

[ "" ]

[ 1865 ]

1

[]

0

[ "8jj5" ]

1

[ "PUB00080626", "PUB00080628", "PUB00084338", "PUB00084359" ]

[ "19340092", "17183244", "27729990", "7760330" ]

[ "Uroplakins in urothelial biology, function, and disease.", "Uroplakins: new molecular players in the biology of urinary tract malformations.", "Uroplakins and their potential applications in urology.", "Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithe...

[ 2009, 2007, 2016, 1995 ]

4

[]

0

null

[ "Vertebrata" ]

[ 1865 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 10, 9, 7 ]

4

true

Family

Uroplakin-3

4

IPR024833

24,833

Regulated endocrine-specific protein 18

RESP18

Family

206

false

Regulated endocrine-specific protein 18 (RESP18) is a major glucocorticoid-responsive protein that is mainly distributed in the peripheral endocrine and neuroendocrine tissues [ ]. The protein shares sequence homology with the luminal region of IA-2, a dense core vesicle (DCV) transmembrane protein involved in insulin ...

[]

0

[ "PANTHER" ]

[ "PTHR17314" ]

[ "" ]

[ 206 ]

1

[]

0

[]

0

[ "PUB00056643", "PUB00056644", "PUB00056647" ]

[ "17951542", "21104147", "9283614" ]

[ "RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.", "Requirement of regulated endocrine-specific protein-18 for development and expression of regulated endocrine-specific protein-18 isoform c in mice.", "Expression of RESP18 ...

[ 2007, 2011, 1997 ]

3

[]

0

null

[ "Eutheria" ]

[ 206 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 6 ]

3

true

Family

Regulated endocrine-specific protein 18

RESP18

2

IPR024836

24,836

Janus kinase and microtubule-interacting protein

JAKMIP

Family

5,333

false

Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate...

[ "GO:0008017", "GO:0019900" ]

[ "microtubule binding", "kinase binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PANTHER" ]

[ "PTHR18935" ]

[ "" ]

[ 5333 ]

1

[]

0

[]

0

[ "PUB00056656", "PUB00056657", "PUB00056658" ]

[ "15277531", "14718537", "17532644" ]

[ "Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.", "Marlin-1, a novel RNA-binding protein associates with GABA receptors.", "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport." ]

[ 2004, 2004, 2007 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 5333 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 25, 26, 15, 22 ]

4

true

Family

Janus kinase and microtubule-interacting protein

JAKMIP

8

IPR024842

24,842

Triple repetitive-sequence of QXXK/R protein

TRIQK

Family

964

false

TRIQK is a small protein family that is conserved across vertebrates. It is named after the characteristic triple repeat of the sequence QXXK/R that is shared by all family members [ ]. The proteins are localised to the endoplasmic reticulum membrane. They may play a role in cell growth and the maintenance of cell morp...

[ "GO:0005789" ]

[ "endoplasmic reticulum membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF15168" ]

[ "TRIQK" ]

[ 964 ]

1

[]

0

[]

0

[ "PUB00056661" ]

[ "18828657" ]

[ "TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 964 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 2 ]

4

true

Family

Triple repetitive-sequence of QXXK/R protein

TRIQK

6

IPR024843

24,843

Dapper

Family

2,749

false

Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction wit...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF15268", "PTHR15919" ]

[ "Dapper", "" ]

[ 2728, 2737 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-4641258", "R-HSA-4641258", "R-MMU-4641258", "R-XTR-4641258" ]

[ "REACTOME:R-DRE-4641258", "REACTOME:R-HSA-4641258", "REACTOME:R-MMU-4641258", "REACTOME:R-XTR-4641258" ]

4

[]

0

[ "PUB00056662", "PUB00056669" ]

[ "16881060", "15539487" ]

[ "Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.", "Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes." ]

[ 2006, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2749 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 9, 7, 11 ]

4

true

Family

Dapper

6

IPR024845

24,845

Actin remodeling regulator NHS-like

NHS-like

Family

7,088

false

Nance-Horan syndrome is an X-linked disorder characterised by congenital cataracts, dental anomalies, dysmorphic features, and, in some cases, mental disabilities [ ]. The syndrome is caused by defects in the NHS gene [ ], which appears to play a key role in the regulation of eye, tooth, brain, and craniofacial develop...

[]

0

[ "PFAM" ]

[ "PF15273" ]

[ "NHS" ]

[ 7088 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013423" ]

[ "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013423" ]

3

[]

0

[ "PUB00056663", "PUB00056664", "PUB00101114", "PUB00151901" ]

[ "15466011", "14564667", "20332100", "27098511" ]

[ "Identification of the gene for Nance-Horan syndrome (NHS).", "Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan syndrome, including severe congenital cataract, dental anomalies, and mental retardation.", "The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD...

[ 2004, 2003, 2010, 2016 ]

4

[]

0

null

[ "Bilateria" ]

[ 7088 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 90, 13, 9, 25 ]

4

true

Family

Actin remodeling regulator NHS-like

NHS-like

8

IPR024849

24,849

Shootin-1

Family

2,391

false

Shootin-1 is involved in the generation of internal asymmetric signals required for neuronal polarisation [ ]. The protein has been shown to interact with phosphatidylinositol 3-kinase (PI 3-kinase), which is a key regulator in the initial events of neuronal polarisation [ ].

[]

0

[ "PANTHER" ]

[ "PTHR46606" ]

[ "" ]

[ 2391 ]

1

[ "REACTOME" ]

[ "R-HSA-437239" ]

[ "REACTOME:R-HSA-437239" ]

1

[]

0

[ "PUB00056670", "PUB00056671" ]

[ "17030985", "16364893" ]

[ "Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization.", "Key regulators in neuronal polarity." ]

[ 2006, 2005 ]

2

[]

0

null

[ "Caldiarchaeum subterraneum", "Opisthokonta" ]

[ 1, 2390 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 4, 1, 1, 5 ]

5

true

Family

Shootin-1

1

IPR024854

24,854

Kinectin

Family

2,478

false

Kinectin is a protein that binds kinesin and has a role in organelle motility [ ]. Different isoforms exist that may be involved in intracellular motility in different cellular processes. As an integral transmembrane protein on the endoplasmic reticulum it is involved in endoplasmic reticulum extension. A smaller isofo...

[ "GO:0019894", "GO:0007018" ]

[ "kinesin binding", "microtubule-based movement" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR18864" ]

[ "" ]

[ 2478 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-5625970", "R-HSA-8957275", "R-HSA-8980692", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013408", "R-HSA-9696264", "R-HSA-9696270", "R-MMU-381426", "R-MMU-5625970", "R-MMU-8957275", "R-MMU-8980692", "R-MMU-9013148", "R-MMU-9013149", "R-MMU-9013408", "R-MMU-9696264...

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-5625970", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-5625970", "REACTOME:...

18

[]

0

[ "PUB00056674", "PUB00056675" ]

[ "10913441", "15316074" ]

[ "Kinectin-kinesin binding domains and their effects on organelle motility.", "Distribution and functions of kinectin isoforms." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Bilateria" ]

[ 2478 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 15, 21, 8 ]

4

true

Family

Kinectin

4

IPR024855

24,855

UNC79

Family

3,370

false

The Protein unc-79 homolog is an auxiliary subunit of the NALCN sodium channel complex which is a voltage-gated ion channel responsible for the resting Na+ permeability that controls neuronal excitability [ , ]. This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited b...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR21696" ]

[ "" ]

[ 3370 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2672351", "R-MMU-2672351" ]

[ "REACTOME:R-HSA-2672351", "REACTOME:R-MMU-2672351" ]

2

[ "7sx3", "7sx4", "7w7g", "7wji" ]

4

[ "PUB00056676", "PUB00069388", "PUB00161728", "PUB00162008" ]

[ "21040849", "19092807", "32620897", "34929720" ]

[ "Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.", "Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.", "Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic f...

[ 2010, 2009, 2020, 2022 ]

4

[]

0

null

[ "Opisthokonta" ]

[ 3370 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 8, 4, 8, 6 ]

6

true

Family

UNC79

9

IPR024857

24,857

Cappuccino

Family

1,688

false

This entry represents the cappuccino family. In mouse, the cappuccino protein is part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. It plays a role in intracellula...

[]

0

[ "PANTHER" ]

[ "PTHR16230" ]

[ "" ]

[ 1688 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-432722", "R-MMU-432722" ]

[ "REACTOME:R-HSA-432722", "REACTOME:R-MMU-432722" ]

2

[]

0

[ "PUB00056682", "PUB00056683" ]

[ "12576321", "11110696" ]

[ "Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).", "Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism." ]

[ 2003, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1688 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 6, 1, 3 ]

5

true

Family

Cappuccino

3

IPR024858

24,858

Golgin subfamily A

GOLGA

Family

3,197

false

Members of the Golgin subfamily A were identified as Golgi auto-antigens [ ]. They might be involved in maintaining cis-Golgi structure [ ]. One of the members of this family, member 2 or GM130, is a specific interacting partner of the small GTPase Rab1b [ ] and plays a key role in the disassembly and reassembly of the...

[ "GO:0005794" ]

[ "Golgi apparatus" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR10881" ]

[ "" ]

[ 3197 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162658", "R-HSA-204005", "R-HSA-6807878", "R-HSA-8862803", "R-HSA-9013148", "R-HSA-9013405", "R-MMU-162658", "R-MMU-204005", "R-MMU-6807878", "R-MMU-9013405", "R-RNO-162658", "R-RNO-204005", "R-RNO-6807878", "R-RNO-9013405" ]

[ "REACTOME:R-HSA-162658", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-8862803", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013405", "REACTOME:R-MMU-162658", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-9013405", "REACTOME:R-RNO-162658", "REACTOME:R-R...

14

[ "6iw8", "6k06" ]

2

[ "PUB00056681", "PUB00056684", "PUB00056685", "PUB00094634", "PUB00094635", "PUB00094658" ]

[ "8315394", "11306556", "10677249", "26363069", "21552007", "26165940" ]

[ "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.", "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b.", "Human autoantibodies to a novel Golgi protein golgin-67: high similarity...

[ 1993, 2001, 2000, 2015, 2011, 2015 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3197 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 8, 4, 79, 10, 11 ]

6

true

Family

Golgin subfamily A

GOLGA

5

IPR024861

24,861

Donson

Family

2,939

false

The downstream neighbour of Son (DONSON) protein, also known as protein humpty dumpy (Hd) in Drosophila, is essential for DNA amplification in the ovary, and is required for cell proliferation during development (the humpty dumpty name arises from the thin-eggshell phenotype of hd mutants) [ ]. Depletion of the Hd prot...

[]

0

[ "PRINTS", "PANTHER" ]

[ "PR02064", "PTHR12972" ]

[ "DONSON", "" ]

[ 2170, 2925 ]

2

[]

0

[ "8ouw", "8q6o", "8q6p" ]

3

[ "PUB00056688" ]

[ "15854909" ]

[ "humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2938, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 12, 5, 1, 2, 9, 10, 3, 6, 6 ]

9

true

Family

Donson

7

IPR024862

24,862

Transient receptor potential cation channel subfamily V

TRPV

Family

13,511

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005216", "GO:0006811", "GO:0016020" ]

[ "monoatomic ion channel activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR10582" ]

[ "" ]

[ 13511 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-3295583", "R-HSA-3295583", "R-HSA-9856530", "R-MMU-3295583", "R-MMU-9856530", "R-RNO-3295583", "R-RNO-9856530" ]

[ "REACTOME:R-CFA-3295583", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-9856530", "REACTOME:R-MMU-3295583", "REACTOME:R-MMU-9856530", "REACTOME:R-RNO-3295583", "REACTOME:R-RNO-9856530" ]

7

[ "2eta", "2etb", "2etc", "2f37", "2nyj", "2pnn", "2rfa", "3j5p", "3j5q", "3j5r", "3j9j", "3jxi", "3jxj", "3w9f", "3w9g", "4dx1", "4dx2", "4n5q", "5an8", "5hi9", "5irx", "5irz", "5is0", "5iwk", "5iwp", "5iwr", "5iwt", "5wo6", "5wo7", "5wo8", "5wo9", "5woa"...

271

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054054", "PUB00100009", "PUB00100025", "PUB00100026", "PUB00100027" ]

[ "18535090", "20025796", "20861159", "19297520", "29464560", "21457451", "25308698", "24368068" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Pharmacology of vanilloid transient receptor potential cation channels.", "Transient Receptor Potential (T...

[ 2008, 2009, 2010, 2009, 2018, 2011, 2014, 2014 ]

8

[]

[ "IPR008344", "IPR008347" ]

0

2

0

[ "Eukaryota" ]

[ 13511 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 14, 3, 45, 21, 24 ]

6

true

Family

Transient receptor potential cation channel subfamily V

TRPV

6

IPR024864

24,864

Nucleoporin Nup54/Nup57/Nup44

Nup54/Nup57/Nup44

Family

4,840

false

Nucleoporins are components of the nuclear pore complex, which is required for trafficking across the nuclear membrane [ ]. Nucleoporins are named for their molecular weight. This entry represents Nup54 from metazoa [ ], and related nucleoporins from yeast and plants.

[ "GO:0005643" ]

[ "nuclear pore" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR13000" ]

[ "" ]

[ 4840 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

85

[ "3t97", "3t98", "4jnv", "5c3l", "5cws", "5ijn", "5ijo", "7n85", "7n9f", "7per", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7wkk", "7woo", "7wot", "8tj5", "9hcj", "9sob" ]

23

[ "PUB00053744", "PUB00056692" ]

[ "9159086", "8707840" ]

[ "From nucleoporins to nuclear pore complexes.", "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins." ]

[ 1997, 1996 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4840 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 3, 16, 2, 13, 1, 1, 4, 4, 1, 1, 7 ]

12

true

Family

Nucleoporin Nup54/Nup57/Nup44

Nup54/Nup57/Nup44

1

IPR024868

24,868

Four-jointed box protein 1/four-jointed protein

FJX1/FJ

Family

956

false

The mouse four-jointed box protein 1 (fjx1) gene and Drosophila four-jointed (fj) gene are homologues [ , , , ]. Fj encodes a partially secreted transmembrane (TM) type II glyco- protein. In Drosophila, the gene is a downstream target of the Notch signalling pathway in leg-segmentation and planar-cell polarity processe...

[]

0

[ "PRINTS", "PANTHER" ]

[ "PR02072", "PTHR13147" ]

[ "4JOINTEDBOX1", "" ]

[ 928, 955 ]

2

[]

0

[]

0

[ "PUB00056704", "PUB00060261", "PUB00060262", "PUB00060263" ]

[ "18028897", "16145673", "16059920", "10072791" ]

[ "The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.", "Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.", "Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophil...

[ 2007, 2005, 2005, 1999 ]

4

[]

0

null

[ "Endozoicomonas numazuensis", "Metazoa" ]

[ 1, 955 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 1, 2 ]

5

true

Family

Four-jointed box protein 1/four-jointed protein

FJX1/FJ

7

IPR024869

24,869

FAM20

Family

5,993

false

FAM20 is a family of secreted proteins with a potential role in regulating differentiation and function of hematopoietic and other tissues. Proteins in this family include FAM20A [ ], FAM20B or glycosaminoglycan xylosylkinase [ ], and FAM20C or dentin matrix protein 4 [ , ].

[]

0

[ "PANTHER" ]

[ "PTHR12450" ]

[ "" ]

[ 5993 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-381426", "R-CEL-8957275", "R-DME-1971475", "R-DME-381426", "R-DME-8957275", "R-DRE-1971475", "R-HSA-1971475", "R-HSA-381426", "R-HSA-8957275", "R-MMU-1971475", "R-MMU-381426", "R-MMU-8957275" ]

[ "REACTOME:R-CEL-381426", "REACTOME:R-CEL-8957275", "REACTOME:R-DME-1971475", "REACTOME:R-DME-381426", "REACTOME:R-DME-8957275", "REACTOME:R-DRE-1971475", "REACTOME:R-HSA-1971475", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-1971475", "REACTOME:R-MMU-381426", "REACTOME:R-...

12

[ "4kqa", "4kqb", "5wrr", "5wrs", "5xom", "5xoo", "5yh0", "5yh2", "5yh3" ]

9

[ "PUB00056705", "PUB00056706", "PUB00056707", "PUB00056708" ]

[ "17369251", "15676076", "19473117", "17924334" ]

[ "Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation.", "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells.", "FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.", ...

[ 2007, 2005, 2009, 2007 ]

4

[]

0

null

[ "Eukaryota", "Polyangia" ]

[ 5990, 3 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 15, 3, 9, 4, 8 ]

6

true

Family

FAM20

8

IPR024872

24,872

HEXIM

Family

1,631

false

Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [ , ]. This prevents P-TEFb f...

[ "GO:0004861", "GO:0017069", "GO:0000122", "GO:0005634", "GO:0005737" ]

[ "cyclin-dependent protein serine/threonine kinase inhibitor activity", "snRNA binding", "negative regulation of transcription by RNA polymerase II", "nucleus", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF15313", "PR02094", "PTHR13469" ]

[ "HEXIM", "HEXIMFAMILY", "" ]

[ 1611, 1452, 1592 ]

3

[]

0

[ "2gd7", "3s9g" ]

2

[ "PUB00056712", "PUB00056716" ]

[ "15713661", "14580347" ]

[ "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.", "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRN...

[ 2005, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1631 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 3, 7, 5, 4 ]

6

true

Family

HEXIM

4

IPR024874

24,874

Transcription factor Maf family

Transcription_factor_Maf_fam

Family

7,000

false

Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors [ ]. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conser...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR10129" ]

[ "" ]

[ 7000 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-983231", "R-GGA-9707616", "R-GGA-9708530", "R-HSA-210745", "R-HSA-5617472", "R-HSA-8940973", "R-HSA-9707587", "R-HSA-9707616", "R-HSA-9708530", "R-HSA-9759194", "R-HSA-9818026", "R-HSA-9818027", "R-HSA-9818028", "R-HSA-9818030", "R-HSA-9818032", "R-HSA-9818035", "R-HSA-9818749...

[ "REACTOME:R-BTA-983231", "REACTOME:R-GGA-9707616", "REACTOME:R-GGA-9708530", "REACTOME:R-HSA-210745", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-8940973", "REACTOME:R-HSA-9707587", "REACTOME:R-HSA-9707616", "REACTOME:R-HSA-9708530", "REACTOME:R-HSA-9759194", "REACTOME:R-HSA-9818026", "REACTOME:...

22

[ "1k1v", "2wt7", "2wty", "3a5t", "4auw", "4eot", "7x5e", "7x5f", "7x5g" ]

9

[ "PUB00056718" ]

[ "17569705" ]

[ "Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes." ]

[ 2007 ]

1

[]

0

null

[ "Avian musculoaponeurotic fibrosarcoma virus AS42", "Endozoicomonas numazuensis", "Eukaryota" ]

[ 1, 1, 6998 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 17, 6, 15, 17, 25 ]

6

true

Family

Transcription factor Maf family

Transcription_factor_Maf_fam

6

IPR024875

24,875

Protein Lines

Protein_Lines

Family

2,352

false

In Drosophila, Lines is a segment polarity protein and a modulator of the Abd-B HOX protein. Lines is needed for Abd-B to activate its downstream targets cut, spalt and ems, which are involved in posterior spiracle morphogenesis [ , , , , ].

[]

0

[ "PANTHER" ]

[ "PTHR16057" ]

[ "" ]

[ 2352 ]

1

[]

0

[]

0

[ "PUB00056764", "PUB00056765", "PUB00056766", "PUB00056767", "PUB00056768" ]

[ "10837029", "8620835", "9477325", "11784087", "14568103" ]

[ "Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines.", "The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila.", "The lines gene of Drosophila is required for specific functions of the Abdominal-B HOX protein.", "drumstick, bowl,...

[ 2000, 1996, 1998, 2001, 2003 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2352 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 9, 4, 9, 6, 5, 4, 28 ]

8

true

Family

Protein Lines

Protein_Lines

8

IPR024881

24,881

T-cell immunomodulatory protein

Tip

Family

3,288

false

T-cell immunomodulatory protein (Tip) is a modulator of T-cell function. It has a protective effect in graft versus host disease model [ ] and may protect the parasite against attack by the host immune system by immunomodulation [ ]. This entry also includes LINKIN from C. elegans. LINKIN is a transmembrane protein req...

[]

0

[ "PANTHER" ]

[ "PTHR13412" ]

[ "" ]

[ 3288 ]

1

[]

0

[]

0

[ "PUB00056729", "PUB00056730", "PUB00076894" ]

[ "12598909", "12833085", "25437307" ]

[ "TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model.", "A TIP on malaria (genomics).", "LINKIN, a new transmembrane protein necessary for cell adhesion." ]

[ 2003, 2003, 2014 ]

3

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "ecological metagenomes" ]

[ 351, 1, 2933, 3 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 6, 8, 1, 7 ]

6

true

Family

T-cell immunomodulatory protein

Tip

9

IPR024882

24,882

Nucleoporin p58/p45/NUP49

NUP58/p45/49

Family

4,759

false

Nucleoporin proteins p58 and p45 are components of the p62 complex, an assembly of four O-linked glycoproteins localised near the central gated channel of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane [ ]. The p45 and p58 isoforms are generated by mRNA alternative splicing...

[ "GO:0008139", "GO:0017056", "GO:0006913", "GO:0005643" ]

[ "nuclear localization sequence binding", "structural constituent of nuclear pore", "nucleocytoplasmic transport", "nuclear pore" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PANTHER" ]

[ "PTHR13437" ]

[ "" ]

[ 4759 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

79

[ "2osz", "3t98", "4jo7", "4jo9", "4jq5", "5c3l", "5cws", "5ijn", "5ijo", "7n85", "7n9f", "7per", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7wkk", "7woo", "7wot", "8tj5", "9sob" ]

24

[ "PUB00056692", "PUB00056731", "PUB00059207", "PUB00101509" ]

[ "8707840", "9795236", "15116432", "30488506" ]

[ "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.", "cDNA cloning and analysis of the expression of nucleoporin p45.", "Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a d...

[ 1996, 1998, 2004, 2019 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4759 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 3, 13, 1, 10, 3, 1, 6, 10, 1, 1, 9 ]

12

true

Family

Nucleoporin p58/p45/NUP49

NUP58/p45/49

9

IPR024884

24,884

N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

NAPE-PLD

Family

8,140

false

N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD) hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) [ ]. It is responsible for the generation of the NAE anandamide, the ligand of cannabinoid and vanilloid receptors [ ]. Although predominantly bacterial, a mit...

[ "GO:0008270", "GO:0070290" ]

[ "zinc ion binding", "N-acylphosphatidylethanolamine-specific phospholipase D activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF038896" ]

[ "NAPE-PLD" ]

[ 8140 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME" ]

[ "3.1.4.54", "PWY-8051", "PWY-8053", "PWY-8055", "R-HSA-2466712" ]

[ "EC:3.1.4.54", "METACYC:PWY-8051", "METACYC:PWY-8053", "METACYC:PWY-8055", "REACTOME:R-HSA-2466712" ]

5

[ "4qn9", "8p90", "8p96", "8pc4" ]

4

[ "PUB00056734", "PUB00056735", "PUB00056736" ]

[ "15878693", "14634025", "16527816" ]

[ "Presence and potential signaling function of N-acylethanolamines and their phospholipid precursors in the yeast Saccharomyces cerevisiae.", "Molecular characterization of a phospholipase D generating anandamide and its congeners.", "Functional analysis of the purified anandamide-generating phospholipase D as a...

[ 2005, 2004, 2006 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinales", "metagenomes" ]

[ 5638, 2447, 24, 31 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 2, 1, 2, 1, 5, 1 ]

7

true

Family

N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

NAPE-PLD

2

IPR024885

24,885

Neuronatin

Family

332

false

Neuronatin is involved in brain development [ ] and may participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system [ ].

[ "GO:0007420" ]

[ "brain development" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF27808", "PTHR15285" ]

[ "Neuronatin", "" ]

[ 331, 318 ]

2

[]

0

[]

0

[ "PUB00056737", "PUB00056739" ]

[ "8024565", "7556909" ]

[ "Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain.", "Segment-specific expression of the neuronatin gene during early hindbrain development." ]

[ 1994, 1995 ]

2

[]

0

null

[ "Eutheria" ]

[ 332 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 9, 7 ]

3

true

Family

Neuronatin

7

IPR024886

24,886

Bone marrow stromal antigen 2

BST2

Family

350

false

Bone marrow stromal antigen 2, also known as tetherin, is an antiretroviral defence protein, that blocks release of enveloped virus from the cell surface [ , , ]. Bst2/tetherin contains two membrane anchors which are employed to retain some enveloped viruses, including HIV-1, tethered to the plasma membrane in the abse...

[ "GO:0051607" ]

[ "defense response to virus" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF16716", "PTHR15190" ]

[ "BST2", "" ]

[ 349, 345 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-HSA-909733", "R-HSA-9692916", "R-MMU-6798695", "R-RNO-6798695" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9692916", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695" ]

5

[ "2x7a", "2xg7", "3mq7", "3mq9", "3mqb", "3mqc", "3ni0", "3nwh" ]

8

[ "PUB00055261", "PUB00056742", "PUB00056745", "PUB00056746", "PUB00056749", "PUB00056750" ]

[ "20940320", "7607676", "18200009", "20686043", "20399176", "19032371" ]

[ "Structural insight into the mechanisms of enveloped virus tethering by tetherin.", "Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.", "Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.", "Infectious Las...

[ 2010, 1995, 2008, 2010, 2010, 2008 ]

6

[]

0

null

[ "Theria" ]

[ 350 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 5 ]

3

true

Family

Bone marrow stromal antigen 2

BST2

1

IPR024887

24,887

Ashwin

Family

1,228

false

Ashwin is a developmental protein that is expressed in the neural plate, and later in the embryonic brain, eyes, and spinal cord [ ]. It may be involved in the regulation cell survival and anteroposterior patterning. Ashwin has been shown to form a complex with HSPC117, which is a catalytic subunit of the tRNA-splicing...

[ "GO:0048598", "GO:0072669" ]

[ "embryonic morphogenesis", "tRNA-splicing ligase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF15323", "PTHR28359" ]

[ "Ashwin", "" ]

[ 1228, 1059 ]

2

[ "GP", "REACTOME" ]

[ "GenProp1707", "R-HSA-6784531" ]

[ "GP:GenProp1707", "REACTOME:R-HSA-6784531" ]

2

[ "9i8v" ]

1

[ "PUB00056743", "PUB00056744" ]

[ "16680723", "21311021" ]

[ "Novel gene ashwin functions in Xenopus cell survival and anteroposterior patterning.", "HSPC117 is the essential subunit of a human tRNA splicing ligase complex." ]

[ 2006, 2011 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1228 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2 ]

4

true

Family

Ashwin

6

IPR024890

24,890

(R)-citramalate synthase CimA

Citramalate_synthase_CimA

Family

221

false

Citramalate (also known as 2-methylate) is an intermediate in a large number of biochemical pathways. This entry represents the archaeal citramalate synthase enzyme CimA, which is thought to be involved in isoleucine biosynthesis [ ].

[ "GO:0043714" ]

[ "(R)-citramalate synthase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01028" ]

[ "CimA" ]

[ 221 ]

1

[ "EC", "METACYC" ]

[ "2.3.3.21", "PWY-5101" ]

[ "EC:2.3.3.21", "METACYC:PWY-5101" ]

2

[]

0

[ "PUB00015474" ]

[ "9864346" ]

[ "(R)-citramalate synthase in methanogenic archaea." ]

[ 1999 ]

1

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 219, 2 ]

2

[]

0

true

Family

(R)-citramalate synthase CimA

Citramalate_synthase_CimA

7

IPR024891

24,891

Antiholin-like protein LrgB

Antiholin-like_LrgB

Family

359

false

Staphylococcus aureus lrgAB operon negatively regulates murein hydrolase activity and promotes tolerance to penicillin [ ]. LgrB inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB.

[]

0

[ "HAMAP" ]

[ "MF_01142" ]

[ "LrgB" ]

[ 359 ]

1

[]

0

[]

0

[ "PUB00009887" ]

[ "10714982" ]

[ "The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance." ]

[ 2000 ]

1

[ "IPR007300" ]

[]

1

0

1

[ "Bacillati" ]

[ 359 ]

1

[]

0

true

Family

Antiholin-like protein LrgB

Antiholin-like_LrgB

3

IPR024893

24,893

ATP phosphoribosyltransferase HisG, short form

ATP_PRibTrfase_HisG_short

Family

9,147

false

ATP phosphoribosyltransferase (ATP-PRT, ) is the enzyme that catalyses the first step in the biosynthesis of histidine in bacteria, fungi and plants as shown below. It is a member of the larger phosphoribosyltransferase superfamily of enzymes which catalyse the condensation of 5-phospho-alpha-D-ribose 1-diphosphate wit...

[ "GO:0003879", "GO:0000105" ]

[ "ATP phosphoribosyltransferase activity", "L-histidine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "CDD" ]

[ "MF_01018", "cd13595" ]

[ "HisG_Short", "PBP2_HisGs" ]

[ 9085, 8864 ]

2

[ "EC" ]

[ "2.4.2.17" ]

[ "EC:2.4.2.17" ]

1

[ "1o63", "1o64", "1usy", "1ve4", "1z7m", "1z7n", "2vd2", "5m8h", "6fca", "6fcc", "6fct", "6fcw", "6fcy", "6fd9", "6ftt", "6fu2", "6fu7", "6fua", "6r02", "7wgk", "7wgm", "7wzy", "7z6r", "7z8u", "8juk", "8oy0" ]

26

[ "PUB00022501", "PUB00028083", "PUB00028134", "PUB00028139", "PUB00103843", "PUB00103844", "PUB00103845" ]

[ "14741209", "11751055", "12511575", "10430882", "22989207", "27191057", "28781362" ]

[ "The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition.", "The PRT protein family.", "Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.", "An aminoacyl-tRNA synthetase paralog with a catalytic rol...

[ 2004, 2001, 2003, 1999, 2012, 2016, 2017 ]

7

[ "IPR001348" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 35, 8979, 9, 124 ]

4

[]

0

true

Family

ATP phosphoribosyltransferase HisG, short form

ATP_PRibTrfase_HisG_short

7

IPR024894

24,894

Bifunctional pantoate ligase/cytidylate kinase

Pantoate_ligase/cytidylate_kin

Family

362

false

This entry represents a bifunctional pantoate ligase/cytidylate kinase resulting from a fusion of the individual enzymes. This fusion has so far only been found in cyanobacteria. Cytidylate kinase ( ) catalyses the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of A...

[ "GO:0004592", "GO:0005524", "GO:0036431", "GO:0006139", "GO:0015940" ]

[ "pantoate-beta-alanine ligase activity", "ATP binding", "dCMP kinase activity", "nucleobase-containing compound metabolic process", "pantothenate biosynthetic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_01349", "NF010004" ]

[ "PanCY", "PRK13477.1" ]

[ 354, 359 ]

2

[ "EC", "EC", "METACYC" ]

[ "2.7.4.25", "6.3.2.1", "PWY-7205" ]

[ "EC:2.7.4.25", "EC:6.3.2.1", "METACYC:PWY-7205" ]

3

[]

0

[ "PUB00008210", "PUB00008211", "PUB00015310", "PUB00019988", "PUB00079800", "PUB00079882", "PUB00079883", "PUB00079884" ]

[ "10223988", "8760912", "9862805", "374975", "7479698", "15565250", "7037743", "10417331" ]

[ "D-Pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction.", "Sequence analysis of the Bacillus subtilis chromosome region between the serA and kdg loci cloned in a yeast artificial chromosome.", "Structures of escherichia co...

[ 1999, 1996, 1998, 1979, 1995, 2004, 1982, 1999 ]

8

[ "IPR003721" ]

[]

1

0

1

[ "Cyanobacteriota" ]

[ 362 ]

1

[]

0

true

Family

Bifunctional pantoate ligase/cytidylate kinase

Pantoate_ligase/cytidylate_kin

3

IPR024896

24,896

Propionate kinase PduW

Propionate_kinase_PduW

Family

668

false

PduW is a propionate kinase that is involved in the catabolism of both propionate and 1,2-propanediol during growth on these substrates [ ]. This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions [ ].

[ "GO:0008980", "GO:0019543", "GO:0051144" ]

[ "propionate kinase activity", "propionate catabolic process", "1,2-propanediol catabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01882", "NF009063" ]

[ "Propion_kin_subfam2", "PRK12397.1" ]

[ 644, 668 ]

2

[ "EC" ]

[ "2.7.2.15" ]

[ "EC:2.7.2.15" ]

1

[ "7fj7", "7fj8", "7fj9", "7fja", "7fjb" ]

5

[ "PUB00016012", "PUB00096913" ]

[ "12700259", "26448059" ]

[ "Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.", "The EutQ and EutP proteins are novel acetate kinases involved in ethanolamine catabolism: physiological im...

[ 2003, 2016 ]

2

[ "IPR004372" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 668 ]

1

[]

0

true

Family

Propionate kinase PduW

Propionate_kinase_PduW

5

IPR024897

24,897

Octanoyltransferase LipL

LipL

Family

1,472

false

Lipoic acid is an organosulphur compound that is an essential coenzyme in several multienzyme complexes, including pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and the glycine cleavage system. Many Gram-positive bacteria, such as Bacillus subtilis, require three proteins for lipoic acid cofactor biosynthesis: L...

[ "GO:0033819", "GO:0009107", "GO:0009249" ]

[ "lipoyl(octanoyl) transferase activity", "lipoate biosynthetic process", "protein lipoylation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_02119" ]

[ "LipL" ]

[ 1472 ]

1

[ "EC", "METACYC" ]

[ "2.3.1.204", "PWY-6987" ]

[ "EC:2.3.1.204", "METACYC:PWY-6987" ]

2

[ "2p5i" ]

1

[ "PUB00056769", "PUB00056770", "PUB00068776" ]

[ "21338420", "21338421", "21768091" ]

[ "A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.", "A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.", "A complex lipoate utilization pathway in Listeria monocytogenes." ]

[ 2011, 2011, 2011 ]

3

[]

0

null

[ "Bacteria" ]

[ 1472 ]

1

[]

0

true

Family

Octanoyltransferase LipL

LipL

8

IPR024898

24,898

Octanoyltransferase LipM

LipM

Family

927

false

Lipoic acid is an organosulphur compound that is an essential coenzyme in several multienzyme complexes, including pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and the glycine cleavage system. Many Gram-positive bacteria, such as Bacillus subtilis, require three proteins for lipoic acid cofactor biosynthesis: L...

[ "GO:0033819", "GO:0009107", "GO:0009249" ]

[ "lipoyl(octanoyl) transferase activity", "lipoate biosynthetic process", "protein lipoylation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_02118" ]

[ "LipM" ]

[ 927 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.3.1.181", "PWY-6987", "PWY-7382" ]

[ "EC:2.3.1.181", "METACYC:PWY-6987", "METACYC:PWY-7382" ]

3

[]

0

[ "PUB00056769", "PUB00056770" ]

[ "21338420", "21338421" ]

[ "A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.", "A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis." ]

[ 2011, 2011 ]

2

[]

0

null

[ "Bacillota" ]

[ 927 ]

1

[]

0

true

Family

Octanoyltransferase LipM

LipM

3