LiteFold/InterPro · Datasets at Hugging Face

IPR025150

25,150

Glycoside hydrolase 123, catalytic domain

GH123_cat

Domain

3,009

false

This entry, formerly known as DUF4091, represents the C-terminal end of members of the glycoside hydrolase family 123 (GH123). A member of this family, beta-D-N-acetylgalactosaminidase from Clostridium perfringens, removes specific terminal N-D-acetylgalactosamine from glycosphingolipids. This catalytic domain folds in...

[]

0

[ "PFAM" ]

[ "PF13320" ]

[ "GH123_cat" ]

[ 3009 ]

1

[]

0

[ "5fqe", "5fqf", "5fqg", "5fqh", "5fr0", "5l7r", "5l7u", "5l7v", "8k2f", "8k2g", "8k2h", "8k2i", "8k2j", "8k2k", "8k2l", "8k2m", "8k2n", "8p4l", "8q8h" ]

19

[ "PUB00100654" ]

[ "27038508" ]

[ "The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 2230, 692, 7, 80 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 4, 9 ]

3

true

Domain

Glycoside hydrolase 123, catalytic domain

GH123_cat

7

IPR025151

25,151

ELYS-like domain

ELYS_dom

Domain

4,003

false

This domain is found in ELYS (embryonic large molecule derived from yolk sac), which is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to humans [ ]. ELYS is important for the assembly of the nuclear pore complex [ ]. The domain is also found in other proteins, such as E3 ubiquitin-protein...

[]

0

[ "PFAM" ]

[ "PF13934" ]

[ "ELYS" ]

[ 4003 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9615933", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9615933", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9615933", "R-MMU-9648025" ]

[ "REACTOME:R-DME-9615933", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9615933", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-...

15

[ "7r5j", "7r5k", "7vci", "7wb4", "9sob" ]

5

[ "PUB00057302", "PUB00057303" ]

[ "17235358", "19019988" ]

[ "MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.", "The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex." ]

[ 2007, 2009 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4003 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Ze...

[ 5, 1, 2, 2, 1, 1, 5, 4, 1, 39 ]

10

true

Domain

ELYS-like domain

ELYS_dom

6

IPR025152

25,152

Domain of unknown function DUF4084

DUF4084

Domain

224

false

This presumed domain is functionally uncharacterised. It is found in proteins from Gram-positive bacteria.

[]

0

[ "PFAM" ]

[ "PF13321" ]

[ "DUF4084" ]

[ 224 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "viral metagenome" ]

[ 223, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF4084

DUF4084

9

IPR025153

25,153

Ead/Ea22-like protein

Ead_Ea22

Family

2,394

false

This family contains phage proteins and bacterial proteins that are likely to represent integrated phage proteins. This family includes the Lambda phage Ea22 early protein as well as the Bacteriophage P22 Ead protein.

[]

0

[ "PFAM" ]

[ "PF13935" ]

[ "Ead_Ea22" ]

[ 2394 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "organismal metagenomes" ]

[ 2192, 200, 2 ]

3

[]

0

true

Family

Ead/Ea22-like protein

Ead_Ea22

1

IPR025154

25,154

Putative metallopeptidase domain

Put_metallopeptidase_dom

Domain

4,379

false

This putative metallopeptidase domain is found mainly in hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF13203" ]

[ "DUF2201_N" ]

[ 4379 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 34, 3923, 6, 281, 135 ]

5

[]

0

true

Domain

Putative metallopeptidase domain

Put_metallopeptidase_dom

7

IPR025155

25,155

WxxW domain

WxxW_domain

Domain

5,671

false

This domain of unknown function carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues. It is found in variable numbers ranging from a single copy up to 32 consecutive copies, as in , from Branchiostoma floridae.

[]

0

[ "PFAM" ]

[ "PF13330" ]

[ "Mucin2_WxxW" ]

[ 5671 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2160916", "R-HSA-2404192", "R-HSA-5083625", "R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-MMU-2160916", "R-MMU-2404192", "R-MMU-913709", "R-MMU-977068", "R-RNO-913709", "R-RNO-977068" ]

[ "REACTOME:R-HSA-2160916", "REACTOME:R-HSA-2404192", "REACTOME:R-HSA-5083625", "REACTOME:R-HSA-5083632", "REACTOME:R-HSA-5083636", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-977068", "REACTOME:R-MMU-2160916", "REACTOME:R-MMU-2404192", "REACTOME:R-MMU-913709", "REACTOME:R...

14

[ "6tm2", "6tm6", "7a5o", "8ck2", "8oer", "8oes", "8ov0", "8qtb", "8qtv", "8s03", "9gvj", "9gvq" ]

12

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "bird metagenome" ]

[ 5644, 26, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 23, 14, 14 ]

4

true

Domain

WxxW domain

WxxW_domain

3

IPR025156

25,156

Ribonuclease M5, C-terminal domain

RNase_M5_C

Domain

4,497

false

This domain lies at the C terminus of ribonuclease M5. The N-terminal domain of this enzyme is a Toprim domain [ ]. Ribonuclease M5 is required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. It cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step [ , ].

[]

0

[ "PFAM" ]

[ "PF13331" ]

[ "DUF4093" ]

[ 4497 ]

1

[ "EC" ]

[ "3.1.26.8" ]

[ "EC:3.1.26.8" ]

1

[ "6tgj", "6tpq" ]

2

[ "PUB00060781", "PUB00060782", "PUB00068727" ]

[ "4215038", "402365", "16077031" ]

[ "In vitro maturation of precursors of 5S ribosomal RNA from Bacillus subtilis.", "Partial purification and properties of a ribosomal RNA maturation endonuclease from Bacillus subtilis.", "The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member." ]

[ 1974, 1977, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4422, 51, 24 ]

3

[]

0

true

Domain

Ribonuclease M5, C-terminal domain

RNase_M5_C

1

IPR025157

25,157

Hemagglutinin repeat

Hemagglutinin_rpt

Repeat

6,517

false

This hemagglutinin repeat is found in hemolysins and filamentous hemagglutinin. Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Filamentous hemagglutinins have a role in host-cell binding and infection.

[]

0

[ "PFAM" ]

[ "PF13332" ]

[ "Fil_haemagg_2" ]

[ 6517 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Vellamovirus", "metagenomes" ]

[ 6422, 59, 5, 5, 26 ]

5

[]

0

true

Repeat

Hemagglutinin repeat

Hemagglutinin_rpt

4

IPR025158

25,158

Mg chelatase-related protein, C-terminal domain

Mg_chelat-rel_C

Domain

22,697

false

This domain is found in proteins of unknown function that are homologus to bacterial magnesium chelatase subunit ChlI.

[]

0

[ "PFAM" ]

[ "PF13335" ]

[ "Mg_chelatase_C" ]

[ 22697 ]

1

[]

0

[ "8rxd", "8rxk", "8rxs", "8rxt" ]

4

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 22188, 4, 45, 460 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Mg chelatase-related protein, C-terminal domain

Mg_chelat-rel_C

7

IPR025159

25,159

AbiEi antitoxin, N-terminal domain

AbiEi_N

Domain

6,009

false

AbiEi is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. Th...

[]

0

[ "PFAM" ]

[ "PF13338" ]

[ "AbiEi_4" ]

[ 6009 ]

1

[]

0

[ "6y8q" ]

1

[ "PUB00075538" ]

[ "24465005" ]

[ "A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 101, 5802, 2, 2, 102 ]

5

[]

0

true

Domain

AbiEi antitoxin, N-terminal domain

AbiEi_N

6

IPR025160

25,160

AATF leucine zipper-containing domain

AATF

Domain

4,474

false

This leucine zipper-containing domain is found in apoptosis antagonizing transcription factor (AATF, also known as Che-1) and related proteins. AATF may function as a general inhibitor of the histone deacetylase HDAC1 [ ]. AATF has been shown to inhibit the abberant production of the amyloid beta peptide 1-42 by direct...

[]

0

[ "PFAM" ]

[ "PF13339" ]

[ "AATF-Che1" ]

[ 4474 ]

1

[ "REACTOME" ]

[ "R-HSA-193648" ]

[ "REACTOME:R-HSA-193648" ]

1

[ "6lqp", "6lqq", "6lqr", "6lqu", "6lqv", "6rxu", "6rxv", "6rxx", "6rxz", "6zqb", "6zqc", "7ajt", "7d63", "7mq8", "7mq9", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z", "9n70", "9n72", "9n73" ]

25

[ "PUB00057306", "PUB00057401" ]

[ "12450794", "14627703" ]

[ "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.", "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Candidatus Kaiseribacteriota", "Eukaryota" ]

[ 2, 4472 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 6, 1, 9, 2, 1, 2, 9, 1, 1, 14 ]

12

true

Domain

AATF leucine zipper-containing domain

AATF

1

IPR025161

25,161

Insertion element IS402-like domain

IS402-like_dom

Domain

24,499

false

This entry represents a domain found in Insertion element IS402 from Burkholderia cepacia and similar sequences mainly found in prokaryotes. Members of this group are putative transposases of the IS4/IS5 family.

[]

0

[ "PFAM" ]

[ "PF13340" ]

[ "DUF4096" ]

[ 24499 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Paenibacillus phage Tripp", "unclassified sequences" ]

[ 150, 24117, 79, 2, 151 ]

5

[]

0

true

Domain

Insertion element IS402-like domain

IS402-like_dom

8

IPR025162

25,162

Recombination activating protein 2, PHD domain

RAG2_PHD

Domain

2,585

false

RAG-2 is an essential component of the lymphoid-specific recombination activating gene RAG1/2 V(D)J recombinase mediating antigen-receptor gene assembly. It contains an acidic hinge region implicated in histone-binding, a non-canonical plant homeodomain (PHD) finger followed by a C-terminal extension of 40 amino acids ...

[]

0

[ "PFAM", "CDD" ]

[ "PF13341", "cd15569" ]

[ "RAG2_PHD", "PHD_RAG2" ]

[ 2585, 1021 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-1266695", "R-HSA-5687128" ]

[ "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

2

[ "2jwo", "2v83", "2v85", "2v86", "2v87", "2v88", "2v89", "3jbw", "3jbx", "3jby", "6cg0", "6cij", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes", "6oet", "6v0v"...

38

[ "PUB00039110", "PUB00049620", "PUB00057307" ]

[ "15964836", "18025461", "18033247" ]

[ "A PHD finger motif in the C terminus of RAG2 modulates recombination activity.", "The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.", "RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination." ]

[ 2005, 2007, 2007 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 2585 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 3 ]

4

true

Domain

Recombination activating protein 2, PHD domain

RAG2_PHD

4

IPR025165

25,165

Domain of unknown function DUF4100

DUF4100

Domain

620

false

This domain is found in a family of uncharacterised proteins mainly found in basidiomycetes.

[]

0

[ "PFAM" ]

[ "PF13352" ]

[ "DUF4100" ]

[ 620 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 620 ]

1

[]

0

true

Domain

Domain of unknown function DUF4100

DUF4100

5

IPR025166

25,166

Integrase, DNA-binding domain

Integrase_DNA_bind_dom

Domain

32,812

false

This domain is found at the N terminus of a wide variety of phage integrase proteins. It is predicted to bind DNA.

[]

0

[ "PFAM" ]

[ "PF13356" ]

[ "Arm-DNA-bind_3" ]

[ 32812 ]

1

[]

0

[ "3jtz", "3ju0", "3rmp" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 32331, 47, 122, 2, 310 ]

5

[ "Escherichia coli (strain K12)" ]

[ 6 ]

1

true

Domain

Integrase, DNA-binding domain

Integrase_DNA_bind_dom

2

IPR025168

25,168

Protein of unknown function DUF3925

DUF3925

Family

149

false

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 70 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13063" ]

[ "DUF3925" ]

[ 149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillaceae" ]

[ 149 ]

1

[]

0

true

Family

Protein of unknown function DUF3925

DUF3925

9

IPR025169

25,169

Protein of unknown function DUF3927

DUF3927

Family

294

false

This family of proteins is found in bacteria and viruses and is functionally uncharacterised. The proteins contain a conserved SVL sequence motif and a single completely conserved residue D that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF13064" ]

[ "DUF3927" ]

[ 294 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammaproteobacteria", "Viruses" ]

[ 278, 16 ]

2

[]

0

true

Family

Protein of unknown function DUF3927

DUF3927

3

IPR025170

25,170

Protein of unknown function DUF3928

DUF3928

Family

130

false

This family of proteins is functionally uncharacterised. Proteins in this family are found in bacteria and are approximately 100 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13065" ]

[ "DUF3928" ]

[ 130 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillaceae" ]

[ 130 ]

1

[]

0

true

Family

Protein of unknown function DUF3928

DUF3928

9

IPR025171

25,171

Protein of unknown function DUF3929

DUF3929

Family

126

false

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 70 amino acids in length and are found in bacteria.

[]

0

[ "PFAM" ]

[ "PF13066" ]

[ "DUF3929" ]

[ 126 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus" ]

[ 126 ]

1

[]

0

true

Family

Protein of unknown function DUF3929

DUF3929

6

IPR025173

25,173

Protein of unknown function DUF3932

DUF3932

Family

131

false

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and are found in bacteria.

[]

0

[ "PFAM" ]

[ "PF13068" ]

[ "DUF3932" ]

[ 131 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus" ]

[ 131 ]

1

[]

0

true

Family

Protein of unknown function DUF3932

DUF3932

5

IPR025174

25,174

Protein of unknown function DUF3933

DUF3933

Family

130

false

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 60 amino acids in length and are found in bacteria.

[]

0

[ "PFAM" ]

[ "PF13069" ]

[ "DUF3933" ]

[ 130 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillaceae" ]

[ 130 ]

1

[]

0

true

Family

Protein of unknown function DUF3933

DUF3933

4

IPR025175

25,175

Protein of unknown function DUF3934

DUF3934

Family

461

false

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 40 amino acids in length and are found in bacteria. They contain two conserved sequence motifs: GTG and SKG.

[]

0

[ "PFAM" ]

[ "PF13070" ]

[ "DUF3934" ]

[ 461 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli" ]

[ 461 ]

1

[]

0

true

Family

Protein of unknown function DUF3934

DUF3934

1

IPR025176

25,176

Protein of unknown function DUF3935

DUF3935

Family

141

false

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 90 amino acids in length and contain two conserved sequence motifs: FVF and LGV.

[]

0

[ "PFAM" ]

[ "PF13071" ]

[ "DUF3935" ]

[ 141 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus" ]

[ 141 ]

1

[]

0

true

Family

Protein of unknown function DUF3935

DUF3935

8

IPR025177

25,177

Cell division inhibitor MciZ

MciZ

Family

638

false

This family of bacterial proteins includes cell division inhibitor MciZ from Bacillus subtilis . MciZ is required during sporulation, blocking Z-ring formation in the mother cell by inhibiting the polymerization of FtsZ [ ]. FtsZ (filamentation temperature-sensitive Z) is the bacterial homologue of tubulin. Crystal str...

[]

0

[ "PFAM" ]

[ "PF13072" ]

[ "MciZ" ]

[ 638 ]

1

[]

0

[ "2mrw", "4u39" ]

2

[ "PUB00089641", "PUB00091017" ]

[ "18284588", "25848052" ]

[ "Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.", "FtsZ filament capping by MciZ, a developmental regulator of bacterial division." ]

[ 2008, 2015 ]

2

[]

0

null

[ "Bacteria", "anaerobic digester metagenome" ]

[ 637, 1 ]

2

[]

0

true

Family

Cell division inhibitor MciZ

MciZ

2

IPR025178

25,178

Lnb, N-terminal periplasmic domain

Lnb_N

Domain

7,469

false

This domain, previously known as DUF4105, is found N-terminal in Lipoprotein N-acyltransferase Lnb from Bacteroides and related uncharacterised bacterial proteins. Lnb functions as a lipoprotein N-acyltransferase in its native cell enviroument [ ]. It is composed of two domains, N-terminal (this entry) and C-terminal α...

[]

0

[ "PFAM" ]

[ "PF13387" ]

[ "Lnb_N" ]

[ 7469 ]

1

[]

0

[]

0

[ "PUB00158892" ]

[ "39495918" ]

[ "Identification and characterization of the lipoprotein N-acyltransferase in Bacteroides." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 7326, 30, 6, 107 ]

4

[]

0

true

Domain

Lnb, N-terminal periplasmic domain

Lnb_N

9

IPR025179

25,179

Protein of unknown function DUF4106

DUF4106

Family

362

false

This family of proteins are found in large numbers in the Trichomonas vaginalis proteome. The function of this protein is unknown.

[]

0

[ "PFAM" ]

[ "PF13388" ]

[ "DUF4106" ]

[ 362 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Phocaeicola intestinalis", "Trichomonas vaginalis (strain ATCC PRA-98 / G3)" ]

[ 1, 361 ]

2

[]

0

true

Family

Protein of unknown function DUF4106

DUF4106

5

IPR025180

25,180

Protein of unknown function DUF4107

DUF4107

Family

581

false

This family of putative proteins are found in Trichomonas vaginalis in large numbers. The function of this protein is unknown.

[]

0

[ "PFAM" ]

[ "PF13389" ]

[ "DUF4107" ]

[ 581 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Trichomonas vaginalis (strain ATCC PRA-98 / G3)" ]

[ 581 ]

1

[]

0

true

Family

Protein of unknown function DUF4107

DUF4107

3

IPR025181

25,181

Protein of unknown function DUF4108

DUF4108

Family

694

false

This family of putative proteins are found in Trichomonas vaginalis in large numbers. The function of this protein is unknown.

[]

0

[ "PFAM" ]

[ "PF13390" ]

[ "DUF4108" ]

[ 694 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Parabasalia" ]

[ 694 ]

1

[]

0

true

Family

Protein of unknown function DUF4108

DUF4108

9

IPR025182

25,182

RNA polymerase-binding protein RbpA

RNApol-bd_RbpA

Family

7,437

false

RbpA binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters [ ]. RbpA stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter. Stimulation occurs in the presence of the transcription...

[ "GO:0001000", "GO:0045893" ]

[ "bacterial-type RNA polymerase core enzyme binding", "positive regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_01483", "PF13397" ]

[ "RbpA", "RbpA" ]

[ 7339, 7437 ]

2

[]

0

[ "2m4v", "2m6o", "2m6p", "4x8k", "5tw1", "5vi5", "5vi8", "6bzo", "6c04", "6c05", "6c06", "6cce", "6ccv", "6dcf", "6edt", "6ee8", "6eec", "6m7j", "6vvs", "6vvt", "6vvv", "6vvx", "6vvy", "6vvz", "6vw0", "7kif", "7kim", "7kin", "7p5x", "8dy7", "8dy9", "8hvr"...

48

[ "PUB00069577", "PUB00069578" ]

[ "16629670", "23605043" ]

[ "The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor.", "The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase." ]

[ 2006, 2013 ]

2

[]

0

null

[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]

[ 7277, 2, 158 ]

3

[]

0

true

Family

RNA polymerase-binding protein RbpA

RNApol-bd_RbpA

2

IPR025183

25,183

Domain of unknown function DUF4110

DUF4110

Domain

2,374

false

This domain is found predominantly at the C terminus of Kelch repeat-containing proteins. However, the exact function of this domain is not known.

[]

0

[ "PFAM" ]

[ "PF13422" ]

[ "DUF4110" ]

[ 2374 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2374 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 6, 1, 4, 1, 11 ]

5

true

Domain

Domain of unknown function DUF4110

DUF4110

2

IPR025184

25,184

Adenylyltransferase AadA, C-terminal domain

AadA_C

Domain

5,457

false

This domain is found at the C-terminal end of Aminoglycoside adenylyltransferase from Salmonella typhimurium (AadA) and other proteins associated with methicillin-resistant bacteria. AadA adenylates the 3''-hydroxyl group of the streptomycin glucosamine ring and the 9-hydroxyl group of the spectinomycin actinamine ring...

[]

0

[ "PFAM" ]

[ "PF13427" ]

[ "AadA_C" ]

[ 5457 ]

1

[]

0

[ "4cs6", "5g4a", "5lpa", "5luh", "6fzb", "6sxj", "6xxq", "6xz0", "7uy4" ]

9

[ "PUB00091136", "PUB00094230", "PUB00100854", "PUB00100855" ]

[ "26527143", "2993813", "29871922", "32253216" ]

[ "Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.", "Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3\") (9).", "Structural mechanism of AadA, a dual-specificity aminoglycoside a...

[ 2015, 1985, 2018, 2020 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Punavirus P1", "plasmids", "unclassified sequences" ]

[ 5286, 145, 3, 2, 2, 19 ]

6

[]

0

true

Domain

Adenylyltransferase AadA, C-terminal domain

AadA_C

2

IPR025186

25,186

Protein of unknown function DUF4119

DUF4119

Family

46

false

The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].

[]

0

[ "PFAM" ]

[ "PF13494" ]

[ "DUF4119" ]

[ 46 ]

1

[]

0

[]

0

[ "PUB00056011", "PUB00056012" ]

[ "15790854", "16735464" ]

[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Bacteroides" ]

[ 46 ]

1

[]

0

true

Family

Protein of unknown function DUF4119

DUF4119

5

IPR025187

25,187

Protein of unknown function DUF4112

DUF4112

Family

5,724

false

This uncharacterised protein family has several highly conserved GD sequence-motifs of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF13430", "PTHR35519" ]

[ "DUF4112", "" ]

[ 5719, 5389 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 3148, 2303, 243, 30 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function DUF4112

DUF4112

5

IPR025188

25,188

Domain of unknown function DUF4113

DUF4113

Domain

10,030

false

This domain of unknown function is usually found at the C terminus of DNA repair polymerase proteins.

[]

0

[ "PFAM" ]

[ "PF13438" ]

[ "DUF4113" ]

[ 10030 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "Viruses", "metagenomes", "plasmids" ]

[ 9916, 1, 16, 3, 90, 4 ]

6

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF4113

DUF4113

3

IPR025189

25,189

Protein of unknown function DUF4121

DUF4121

Family

336

false

The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].

[]

0

[ "PFAM" ]

[ "PF13497" ]

[ "DUF4121" ]

[ 336 ]

1

[]

0

[]

0

[ "PUB00056011", "PUB00056012" ]

[ "15790854", "16735464" ]

[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Bacteria", "human gut metagenome", "unclassified Caudoviricetes" ]

[ 332, 1, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF4121

DUF4121

6

IPR025190

25,190

Protein of unknown function DUF4122

DUF4122

Family

278

false

The function of this protein is not known, but the Bacteroides thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to pure culture [ , ].

[]

0

[ "PFAM" ]

[ "PF13498" ]

[ "DUF4122" ]

[ 278 ]

1

[]

0

[]

0

[ "PUB00056011", "PUB00056012" ]

[ "15790854", "16735464" ]

[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Bacteroidales", "Podoviridae sp. ctHm32", "organismal metagenomes" ]

[ 274, 1, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF4122

DUF4122

6

IPR025191

25,191

Protein of unknown function DUF4125

DUF4125

Family

571

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF13526" ]

[ "DUF4125" ]

[ 571 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Aduncisulcus paluster", "Bacteria", "Methanobacteriati", "metagenomes" ]

[ 2, 559, 2, 8 ]

4

[]

0

true

Family

Protein of unknown function DUF4125

DUF4125

2

IPR025192

25,192

Succinate dehydogenase/fumarate reductase N-terminal

Succ_DH/fum_Rdtase_N

Domain

34,170

false

This entry represents the 2Fe-2S iron-sulphur cluster binding domain found in members of the succinate dehydrogenase/fumarate reductase protein family. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.

[ "GO:0009055", "GO:0051536" ]

[ "electron transfer activity", "iron-sulfur cluster binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF13085" ]

[ "Fer2_3" ]

[ 34170 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.3.5.1", "PWY-3781", "PWY-4302", "PWY-5392", "PWY-561", "PWY-5690", "PWY-5913", "PWY-6728", "PWY-6969", "PWY-7254", "PWY-7279", "PWY-7384", "PWY-8086", "R-CEL-71403", "R-DDI-71403", "R-DME-71403", "R-DRE-71403", "R-GGA-372987", "R-HSA-611105", "R-HSA-71403", "R-HSA-9854311"...

[ "EC:1.3.5.1", "METACYC:PWY-3781", "METACYC:PWY-4302", "METACYC:PWY-5392", "METACYC:PWY-561", "METACYC:PWY-5690", "METACYC:PWY-5913", "METACYC:PWY-6728", "METACYC:PWY-6969", "METACYC:PWY-7254", "METACYC:PWY-7279", "METACYC:PWY-7384", "METACYC:PWY-8086", "REACTOME:R-CEL-71403", "REACTOME:R...

28

[ "1e7p", "1kf6", "1kfy", "1l0v", "1nek", "1nen", "1qlb", "1yq3", "1yq4", "1zoy", "1zp0", "2acz", "2b76", "2bs2", "2bs3", "2bs4", "2fbw", "2h88", "2h89", "2wdq", "2wdr", "2wdv", "2wp9", "2wqy", "2ws3", "2wu2", "2wu5", "3abv", "3ae1", "3ae2", "3ae3", "3ae4"...

101

[]

0

[ "IPR001041" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 787, 26711, 6102, 569, 1 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 2, 1, 3, 2, 10, 4, 2, 6, 7, 1, 1, 20 ]

13

true

Domain

Succinate dehydogenase/fumarate reductase N-terminal

Succ_DH/fum_Rdtase_N

7

IPR025193

25,193

Domain of unknown function DUF4114

DUF4114

Domain

1,995

false

This domain of unknown function is found in many different types of protein. There are highly conserved glutamate and aspartate residues suggesting that this domain might carry enzymic activity.

[]

0

[ "PFAM" ]

[ "PF13448" ]

[ "DUF4114" ]

[ 1995 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Megaviricetes", "Methanomicrobia", "metagenomes" ]

[ 1965, 7, 3, 11, 9 ]

5

[]

0

true

Domain

Domain of unknown function DUF4114

DUF4114

3

IPR025194

25,194

Cytoskeleton protein RodZ-like, C-terminal domain

RodZ-like_C

Domain

13,323

false

This short domain is often found at the C terminus of cytoskeleton RodZ proteins, which contain a helix-turn-helix domain. The function of this domain, previously known as DUF4115, is unknown.

[]

0

[ "PFAM" ]

[ "PF13464" ]

[ "RodZ_C" ]

[ 13323 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_94_C01" ]

[ 13070, 13, 239, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Cytoskeleton protein RodZ-like, C-terminal domain

RodZ-like_C

2

IPR025195

25,195

GTA, TIM-barrel-like domain

GTA_TIM

Domain

1,869

false

This domain, which appears to have a TIM barrel fold, is found in the gene transfer agent protein. An unusual system of genetic exchange exists in the purple nonsulphur bacterium Rhodobacter capsulatus. DNA transmission is mediated by a small bacteriophage-like particle called the gene transfer agent (GTA) that transfe...

[]

0

[ "PFAM" ]

[ "PF13547" ]

[ "GTA_TIM" ]

[ 1869 ]

1

[]

0

[ "6tba", "6teh", "8gtc" ]

3

[ "PUB00056215", "PUB00057310" ]

[ "17184993", "10639170" ]

[ "Importance of widespread gene transfer agent genes in alpha-proteobacteria.", "Genetic analysis of a bacterial genetic exchange element: the gene transfer agent of Rhodobacter capsulatus." ]

[ 2007, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1830, 9, 17, 13 ]

4

[]

0

true

Domain

GTA, TIM-barrel-like domain

GTA_TIM

4

IPR025196

25,196

Domain of unknown function DUF4126

DUF4126

Domain

5,576

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF13548" ]

[ "DUF4126" ]

[ 5576 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12, 5463, 48, 53 ]

4

[]

0

true

Domain

Domain of unknown function DUF4126

DUF4126

8

IPR025197

25,197

Domain of unknown function DUF4116

DUF4116

Domain

3,226

false

This entry represents a domain found in proteins from lower eukaryotes and bacteria. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF13475" ]

[ "DUF4116" ]

[ 3226 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 564, 2514, 42, 106 ]

4

[]

0

true

Domain

Domain of unknown function DUF4116

DUF4116

2

IPR025198

25,198

Polyphosphate kinase N-terminal domain

PPK_N_dom

Domain

21,874

false

Polyphosphate kinase (PPK) catalyses the formation of polyphosphate from ATP, with polyphosphate chain lengths of up to a thousand or more orthophosphate molecules. This entry represents the PPK N-terminal domain, which consists of three α helices [ ].

[]

0

[ "PFAM" ]

[ "PF13089" ]

[ "PP_kinase_N" ]

[ 21874 ]

1

[ "EC", "METACYC" ]

[ "2.7.4.1", "PWY-8138" ]

[ "EC:2.7.4.1", "METACYC:PWY-8138" ]

2

[ "1xdo", "1xdp", "2o8r" ]

3

[ "PUB00038273" ]

[ "15947782" ]

[ "Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 21171, 75, 343, 285 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Polyphosphate kinase N-terminal domain

PPK_N_dom

2

IPR025199

25,199

DNA translocase FtsK, 4TM region

FtsK_4TM

Domain

20,422

false

This entry represents the integral membrane domain of the FtsK DNA tranlocases. During sporulation in Bacillus subtilis, the SpoIIIE protein is believed to form a translocation pore at the leading edge of the nearly closed septum. The E. coli FtsK protein is homologous to SpoIIIE, and can free chromosomes trapped in ve...

[]

0

[ "PFAM" ]

[ "PF13491" ]

[ "FtsK_4TM" ]

[ 20422 ]

1

[]

0

[]

0

[ "PUB00041785", "PUB00041884", "PUB00049695" ]

[ "16916635", "17057717", "18722176" ]

[ "Double-stranded DNA translocation: structure and mechanism of hexameric FtsK.", "The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.", "Molecular mechanism of sequence-directed DNA loading and translocation by FtsK." ]

[ 2006, 2006, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_68_B04" ]

[ 19950, 28, 443, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA translocase FtsK, 4TM region

FtsK_4TM

5

IPR025200

25,200

Polyphosphate kinase C-terminal domain 2

PPK_C_dom2

Domain

22,027

false

Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C2-terminal domain has a structure similar to phospholipase D. It is one of two closely related carboxy-terminal domains (C1 and C2 domains). Both the C1 and C2 dom...

[]

0

[ "PFAM" ]

[ "PF13090" ]

[ "PP_kinase_C" ]

[ 22027 ]

1

[ "EC", "METACYC" ]

[ "2.7.4.1", "PWY-8138" ]

[ "EC:2.7.4.1", "METACYC:PWY-8138" ]

2

[ "1xdo", "1xdp", "2o8r" ]

3

[ "PUB00038273" ]

[ "15947782" ]

[ "Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 21246, 88, 346, 347 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Polyphosphate kinase C-terminal domain 2

PPK_C_dom2

7

IPR025201

25,201

Sensor protein KdpD, transmembrane domain

KdpD_TM

Domain

17,010

false

This domain is found in sensor protein KdpD. It is likely to be a transmembrane domain involved in ligand sensing. KdpD is part of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon, a three-component K+ transport system. KdpD may function as a membrane-associated protein kinase ...

[]

0

[ "PFAM" ]

[ "PF13493" ]

[ "DUF4118" ]

[ 17010 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "2ksf" ]

1

[ "PUB00007568" ]

[ "1532388" ]

[ "KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor-effector class of regulators." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 16860, 9, 26, 115 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Sensor protein KdpD, transmembrane domain

KdpD_TM

9

IPR025202

25,202

Cardiolipin synthase-like, phospholipase D-like domain

PLD-like_dom

Domain

80,441

false

This entry represents a phospholipase D-like domain, found in cardiolipin synthases and related proteins. Cardiolipin synthases catalyse the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [ ]. Mitochondrial cardioli...

[]

0

[ "PFAM" ]

[ "PF13091" ]

[ "PLDc_2" ]

[ 80441 ]

1

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.7.8.-", "GenProp1252", "GenProp1453", "GenProp1542", "PWY-6350", "PWY-6580", "PWY-6804", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7819", "PWY-7820", "PWY-7981", "PWY-8248", "R-BTA-1483166", "R-DDI-1483166", "R-DDI-2029485", "R-DDI-6798695", "R-DDI-9013149", "R-...

[ "EC:2.7.8.-", "GP:GenProp1252", "GP:GenProp1453", "GP:GenProp1542", "METACYC:PWY-6350", "METACYC:PWY-6580", "METACYC:PWY-6804", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7819", "METACYC:PWY-7820", "METACYC:PWY-7981", "METACYC:PWY-8248", ...

49

[ "1byr", "1bys", "1f0i", "1v0r", "1v0s", "1v0t", "1v0u", "1v0v", "1v0w", "1v0y", "2c1l", "2ze4", "2ze9", "3hsi", "4gel", "4gem", "4gen", "4ggj", "4ggk", "4h4a", "6ehi", "6ohm", "6oho", "6ohp", "6ohq", "6ohr", "6ohs", "6u8z", "7clg", "7e0m", "7jrb", "7jrc"...

45

[ "PUB00077967", "PUB00163408", "PUB00163409", "PUB00163410", "PUB00163411", "PUB00163412", "PUB00163413", "PUB00163414", "PUB00163415" ]

[ "26711011", "26678338", "28063496", "12775839", "16384909", "16891548", "25936805", "8530346", "9582313" ]

[ "Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.", "A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.", "Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods.",...

[ 2016, 2015, 2017, 2003, 2006, 2006, 2015, 1995, 1998 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Plasmid R64", "Viruses", "unclassified sequences" ]

[ 1100, 62843, 15787, 1, 36, 674 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 14, 1, 17, 13, 5, 11, 10, 5, 6, 14, 24 ]

11

true

Domain

Cardiolipin synthase-like, phospholipase D-like domain

PLD-like_dom

9

IPR025203

25,203

Putative quorum-sensing-regulated virulence factor, QSregVF

QSregVF

Family

779

false

This entry represents a family of short 14kDa proteins from Psuedomonas. The structure of a secreted protein has been solved and deposited as PDB:3npd. It comprises one structural domain with five β-strands and five α-helices. Various comparative structural prediction methods plus its genomic location point to the prot...

[]

0

[ "PFAM" ]

[ "PF13652" ]

[ "QSregVF" ]

[ 779 ]

1

[]

0

[ "3npd" ]

1

[ "PUB00075641" ]

[ "24174223" ]

[ "Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 776, 3 ]

2

[]

0

true

Family

Putative quorum-sensing-regulated virulence factor, QSregVF

QSregVF

7

IPR025204

25,204

Centromere subunit L

CENP-L

Family

2,320

false

CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. It interacts with CENP-N and forms a deep channel through which a DNA duplex threads [ ]. Fta1 is the equivalent component of the fission yeast Sim4 complex [ ]. The centromere, which is the basic element of chromosome in...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF13092", "PTHR31740" ]

[ "CENP-L", "" ]

[ 2311, 1378 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-141444", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-5663220", "R-BTA-606279", "R-BTA-68877", "R-BTA-9648025", "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-5663220", "R-GGA-606279", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", ...

[ "REACTOME:R-BTA-141444", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-606279", "REACTOME:R-BTA-68877", "REACTOME:R-BTA-9648025", "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-5663220", "REACTOME:R-G...

41

[ "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh" ]

8

[ "PUB00044193", "PUB00044194", "PUB00154823" ]

[ "16079914", "16622419", "35420891" ]

[ "Molecular analysis of kinetochore architecture in fission yeast.", "The human CENP-A centromeric nucleosome-associated complex.", "Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome." ]

[ 2005, 2006, 2022 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2320 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 3, 1, 8, 1 ]

6

true

Family

Centromere subunit L

CENP-L

6

IPR025205

25,205

PilX/PilW C-terminal domain

PilX/PilW_C

Domain

1,610

false

This domain is found at the C terminus of the type IV pilus assembly proteins PilX and PilW.

[]

0

[ "PFAM" ]

[ "PF13681" ]

[ "PilX" ]

[ 1610 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "unclassified sequences" ]

[ 2, 1574, 34 ]

3

[]

0

true

Domain

PilX/PilW C-terminal domain

PilX/PilW_C

3

IPR025206

25,206

Protein of unknown function DUF4152

DUF4152

Family

45

false

This family of archaeal proteins is functionally uncharacterised. The structure of the family member from Pyrococcus furiosus has been solved. It shows an RNaseH like fold that conserves critical catalytic residues [ ]. This suggests that these proteins may cleave nucleic acid.

[]

0

[ "PFAM" ]

[ "PF13680" ]

[ "DUF4152" ]

[ 45 ]

1

[]

0

[ "4o8u", "4yor", "4yot", "4you", "4yov", "4yow", "4yox", "4yoy", "5chi" ]

9

[ "PUB00057311" ]

[ "21203960" ]

[ "Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods." ]

[ 2010 ]

1

[]

0

null

[ "Archaea" ]

[ 45 ]

1

[]

0

true

Family

Protein of unknown function DUF4152

DUF4152

7

IPR025207

25,207

Kinetochore Sim4 complex subunit Fta4

Sim4_Fta4

Family

1,095

false

Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock...

[ "GO:0031511" ]

[ "Mis6-Sim4 complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF13093", "PTHR42040" ]

[ "FTA4", "" ]

[ 1094, 925 ]

2

[]

0

[]

0

[ "PUB00044193" ]

[ "16079914" ]

[ "Molecular analysis of kinetochore architecture in fission yeast." ]

[ 2005 ]

1

[]

0

null

[ "Opisthokonta", "Pseudomonadati" ]

[ 1093, 2 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Kinetochore Sim4 complex subunit Fta4

Sim4_Fta4

1

IPR025208

25,208

NFkB-p65-degrading zinc protease

Peptidase_M85

Family

116

false

This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65, thereby down-regulating the NF-kappaB signalling pathway [ ]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as i...

[]

0

[ "PFAM" ]

[ "PF13678" ]

[ "Peptidase_M85" ]

[ 116 ]

1

[]

0

[ "4lgi", "4lgj", "4o2i", "4q3j", "7zpf" ]

5

[ "PUB00057312" ]

[ "21187904" ]

[ "NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA." ]

[ 2010 ]

1

[]

0

null

[ "Cacopsylla melanoneura", "Pseudomonadota" ]

[ 9, 107 ]

2

[]

0

true

Family

NFkB-p65-degrading zinc protease

Peptidase_M85

6

IPR025209

25,209

Endoplasmic reticulum membrane-associated RNA degradation protein, N-terminal

EMARD_N

Domain

2,149

false

This entry represents a conserved domain found at the N-terminal of Endoplasmic reticulum membrane-associated RNA degradation protein (EMARD), described as KEN domain, which contains the highly conserved RxxxxHG sequence motif from HEPN domains superfamily [ ]. This domain may be a RNase that is involved in the degrada...

[]

0

[ "PFAM" ]

[ "PF13910" ]

[ "DUF4209" ]

[ 2149 ]

1

[]

0

[]

0

[ "PUB00089893", "PUB00091124" ]

[ "24056535", "23768067" ]

[ "Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene.", "Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 637, 1489, 16, 7 ]

4

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 7, 3 ]

3

true

Domain

Endoplasmic reticulum membrane-associated RNA degradation protein, N-terminal

EMARD_N

8

IPR025210

25,210

ATP25 mRNA stabilisation domain

ATP25_mRNA_stabil_dom

Domain

70

false

This domain is found in ATPase synthesis protein 25. It acts as an mRNA stabilisation factor [ ].

[ "GO:0048255" ]

[ "mRNA stabilization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF13929" ]

[ "mRNA_stabil" ]

[ 70 ]

1

[]

0

[]

0

[ "PUB00057313" ]

[ "18216280" ]

[ "ATP25, a new nuclear gene of Saccharomyces cerevisiae required for expression and assembly of the Atp9p subunit of mitochondrial ATPase." ]

[ 2008 ]

1

[]

0

null

[ "saccharomyceta" ]

[ 70 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

ATP25 mRNA stabilisation domain

ATP25_mRNA_stabil_dom

2

IPR025211

25,211

Toxin TisB, type I toxin-antitoxin system

TisB_toxin

Family

466

false

TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide and is part of the type I toxin-antitoxin system, in which the antitoxin is a non-coding RNA. It is a hydrophobic membrane-spanning protein that inhibits cell growth [ ]. Its expression is inhibited by the antisense RNA IstR-1 [ ]. TisB appears to induce ...

[ "GO:0005253", "GO:0009432", "GO:0022611", "GO:0005886" ]

[ "monoatomic anion channel activity", "SOS response", "dormancy process", "plasma membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "NCBIFAM" ]

[ "PF13939", "TIGR04459" ]

[ "TisB_toxin", "TisB_tox" ]

[ 465, 457 ]

2

[ "GP" ]

[ "GenProp1091" ]

[ "GP:GenProp1091" ]

1

[]

0

[ "PUB00057314", "PUB00057315", "PUB00074354", "PUB00074355" ]

[ "18761622", "15620655", "23062338", "22728134" ]

[ "A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli.", "The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide.", "Peptide-lipid interactions of the stress-response peptide TisB that induces bacterial persistence.", "Persister-promoting bacterial toxin TisB pro...

[ 2008, 2004, 2012, 2012 ]

4

[]

0

null

[ "Gammaproteobacteria" ]

[ 466 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Toxin TisB, type I toxin-antitoxin system

TisB_toxin

4

IPR025212

25,212

Centromere protein Q

CAD_CENP-Q

Family

1,998

false

This entry includes CENP-Q and Fta7 proteins. CENP-Q is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. Fta7 is the equivalent component of the fission yeast Sim4 complex [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF13094", "PTHR31345" ]

[ "CENP-Q", "" ]

[ 1887, 939 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-606279", "R-MMU-68877", "R-MMU-9648025", "R-RNO-141444", "R-RNO-2467813", "R-RNO-2500257", "R...

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-606279", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-M...

21

[ "7pb8", "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh" ]

9

[ "PUB00044193", "PUB00044194" ]

[ "16079914", "16622419" ]

[ "Molecular analysis of kinetochore architecture in fission yeast.", "The human CENP-A centromeric nucleosome-associated complex." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Eukaryota", "Halovenus salina", "Mariprofundus micogutta" ]

[ 1996, 1, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 1, 5, 1 ]

6

true

Family

Centromere protein Q

CAD_CENP-Q

9

IPR025213

25,213

Kinetochore Sim4 complex subunit Fta2

Sim4_Fta2

Family

1,209

false

Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock...

[]

0

[ "PFAM" ]

[ "PF13095" ]

[ "FTA2" ]

[ 1209 ]

1

[]

0

[]

0

[ "PUB00044193" ]

[ "16079914" ]

[ "Molecular analysis of kinetochore architecture in fission yeast." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1209 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Family

Kinetochore Sim4 complex subunit Fta2

Sim4_Fta2

4

IPR025214

25,214

Centromere protein U

CENP-U

Family

1,003

false

CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. All active centromeres are characterised by the presence of long arrays of nucleosomes in which CENP-A replac...

[]

0

[ "PFAM" ]

[ "PF13097" ]

[ "CENP-U" ]

[ 1003 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-606279", "R-MMU-68877", "R-MMU-9648025", "R-RNO-141444", "R-RNO-2467813", "R-RNO-2500257", "R...

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-606279", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-M...

21

[ "7pb8", "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh" ]

9

[ "PUB00044194" ]

[ "16622419" ]

[ "The human CENP-A centromeric nucleosome-associated complex." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1003 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 2, 4 ]

4

true

Family

Centromere protein U

CENP-U

9

IPR025216

25,216

Domain of unknown function DUF4427

DUF4427

Domain

850

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14468" ]

[ "DUF4427" ]

[ 850 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 849, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF4427

DUF4427

9

IPR025217

25,217

Domain of unknown function DUF3944

DUF3944

Domain

1,076

false

This domain of unknown function is found in uncharacterised proteins from bacteria.

[]

0

[ "PFAM" ]

[ "PF13099" ]

[ "DUF3944" ]

[ 1076 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Myoviridae sp. ctoNH1", "Opisthokonta", "uncultured organism" ]

[ 1072, 1, 2, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF3944

DUF3944

8

IPR025218

25,218

Domain of unknown function DUF4426

DUF4426

Domain

2,161

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14467" ]

[ "DUF4426" ]

[ 2161 ]

1

[]

0

[ "3uc2" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2132, 4, 25 ]

3

[]

0

true

Domain

Domain of unknown function DUF4426

DUF4426

2

IPR025220

25,220

Nuclear factor related to kappa-B-binding protein, winged helix-like domain

NFRKB_WH_1

Domain

1,748

false

This winged helix-like domain is found in nuclear factor related to kappa-B-binding (NFRKB) protein. This winged helix-like domain is however not involved in DNA binding but is instead thought to be involved in protein-protein interactions [ ]. NFRKB is a putative regulatory component of the chromatin remodelling INO80...

[]

0

[ "PFAM" ]

[ "PF14465" ]

[ "WHD_1st_NFRKB" ]

[ 1748 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5689603", "R-HSA-5696394", "R-MMU-5689603", "R-MMU-5696394" ]

[ "REACTOME:R-HSA-5689603", "REACTOME:R-HSA-5696394", "REACTOME:R-MMU-5689603", "REACTOME:R-MMU-5696394" ]

4

[ "3u21" ]

1

[ "PUB00056693", "PUB00062551" ]

[ "18922472", "22984442" ]

[ "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.", "Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein." ]

[ 2008, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1748 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 1, 3 ]

5

true

Domain

Nuclear factor related to kappa-B-binding protein, winged helix-like domain

NFRKB_WH_1

6

IPR025221

25,221

E1 N-terminal domain

E1-N_dom

Domain

22

false

This entry represents an uncharacterised α/β domain fused to E1 proteins. This protein is usually present in gene neighbourhoods with genes encoding a JAB protein and a predicted metal-binding protein. In related E1 proteins, the E1-N domain is replaced by an E2/UBC superfamily domain [ ].

[]

0

[ "PFAM" ]

[ "PF14463" ]

[ "E1-N" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00034476" ]

[ "16859499" ]

[ "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains." ]

[ 2006 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 22 ]

1

[]

0

true

Domain

E1 N-terminal domain

E1-N_dom

5

IPR025223

25,223

S1-like RNA binding domain

S1-like_RNA-bd_dom

Domain

2,833

false

This entry represents the S1-like RNA binding domain found in deleted in breast cancer 1 (DBC1) and its paralogue cell division cycle and apoptosis regulator protein 1 (CARP1) [ ].

[]

0

[ "PFAM" ]

[ "PF14444" ]

[ "S1-like" ]

[ 2833 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-3371453", "R-HSA-72163" ]

[ "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-72163" ]

2

[ "8ez6" ]

1

[ "PUB00057316" ]

[ "18418069" ]

[ "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2833 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 12, 13, 4, 10 ]

5

true

Domain

S1-like RNA binding domain

S1-like_RNA-bd_dom

7

IPR025224

25,224

Cell cycle and apoptosis regulator protein

CCAR1/CCAR2

Family

4,230

false

Cell division cycle and apoptosis regulator protein 1 (CCAR1) associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery. CCAR1 also functions as a p53 coact...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR14304" ]

[ "" ]

[ 4230 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-3371453", "R-HSA-72163" ]

[ "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-72163" ]

2

[ "8ez6" ]

1

[ "PUB00057203", "PUB00069353", "PUB00069355", "PUB00070943", "PUB00090173", "PUB00098741" ]

[ "18235501", "23352644", "19657230", "18722177", "24009530", "32692742" ]

[ "DBC1 is a negative regulator of SIRT1.", "Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage.", "p30 DBC is a potential regulator of tumorigenesis.", "CCAR1, a key regulator of mediator complex recruitment to nuclear re...

[ 2008, 2013, 2009, 2008, 2013, 2020 ]

6

[]

0

null

[ "Eukaryota", "Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764)" ]

[ 4229, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 4, 10, 17, 3, 4, 11, 43 ]

8

true

Family

Cell cycle and apoptosis regulator protein

CCAR1/CCAR2

5

IPR025225

25,225

Protein of unknown function DUF3956

DUF3956

Family

145

false

Family of uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF13104" ]

[ "DUF3956" ]

[ 145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 145 ]

1

[]

0

true

Family

Protein of unknown function DUF3956

DUF3956

6

IPR025226

25,226

Protein of unknown function DUF4170

DUF4170

Family

2,571

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF13773" ]

[ "DUF4170" ]

[ 2571 ]

1

[]

0

[ "2mhe" ]

1

[]

0

[]

0

null

[ "Bacteria", "Diploscapter pachys", "Jeanschmidtviridae", "ecological metagenomes" ]

[ 2539, 1, 9, 22 ]

4

[]

0

true

Family

Protein of unknown function DUF4170

DUF4170

5

IPR025227

25,227

Protein of unknown function DUF4169

DUF4169

Family

2,466

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF13770" ]

[ "DUF4169" ]

[ 2466 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Aduncisulcus paluster", "Pseudomonadati", "ecological metagenomes" ]

[ 1, 2450, 15 ]

3

[]

0

true

Family

Protein of unknown function DUF4169

DUF4169

4

IPR025228

25,228

Domain of unknown function DUF4171

DUF4171

Domain

1,044

false

The function of this domain is not known. It is often found at the N terminus of proteins that contain an HMG-box domain.

[]

0

[ "PFAM" ]

[ "PF13775" ]

[ "DUF4171" ]

[ 1044 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 1044 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 10, 5, 5 ]

4

true

Domain

Domain of unknown function DUF4171

DUF4171

5

IPR025229

25,229

YniB-like protein

YniB-like

Family

1,271

false

The YniB-like protein family includes the Escherichia coli YniB protein , which is functionally uncharacterised. It also includes protein YfeE from Yersinia, a putative regulator of the ABC transporter locus yfeABCD, involved in inorganic iron transport. The proteins in this family are integral membrane proteins and ar...

[]

0

[ "PFAM" ]

[ "PF14002" ]

[ "YniB" ]

[ 1271 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "metagenomes" ]

[ 1268, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YniB-like protein

YniB-like

6

IPR025230

25,230

Domain of unknown function DUF4172

DUF4172

Domain

3,329

false

The function of this domain is not known. It is often associated with a Fido domain [ ].

[]

0

[ "PFAM" ]

[ "PF13776" ]

[ "DUF4172" ]

[ 3329 ]

1

[]

0

[ "8cil" ]

1

[ "PUB00057404" ]

[ "19503829" ]

[ "Fido, a novel AMPylation domain common to fic, doc, and AvrB." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 3250, 5, 7, 67 ]

4

[]

0

true

Domain

Domain of unknown function DUF4172

DUF4172

4

IPR025232

25,232

Domain of unknown function DUF4174

DUF4174

Domain

6,068

false

This domain of unknown function is found in a putative tumour suppressor gene [ ] and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion [ , ].

[]

0

[ "PFAM" ]

[ "PF13778" ]

[ "DUF4174" ]

[ 6068 ]

1

[]

0

[]

0

[ "PUB00057318", "PUB00057319", "PUB00057320" ]

[ "15563452", "18718938", "19667118" ]

[ "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.", "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.", "Sushi repeat protein X-linked 2, a...

[ 2005, 2008, 2009 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2753, 3304, 11 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 10, 4, 7 ]

4

true

Domain

Domain of unknown function DUF4174

DUF4174

2

IPR025233

25,233

Protein of unknown function DUF4176

DUF4176

Family

1,789

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF13780" ]

[ "DUF4176" ]

[ 1789 ]

1

[]

0

[ "9dcs", "9mno" ]

2

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Trichuris trichiura", "metagenomes" ]

[ 1782, 2, 1, 4 ]

4

[]

0

true

Family

Protein of unknown function DUF4176

DUF4176

5

IPR025234

25,234

YjzH-like

Family

3,438

false

This entry represents a group of prokaryotic proteins, including the uncharacterised protein YjzH from Bacillus subtilis. YjzH is a member of the sigma W regulon, which is induced in response to cell envelope stress caused by antibiotics, alkaline shock and salt shock [ ]. This family was previously known as DUF4177.

[]

0

[ "PFAM" ]

[ "PF13783" ]

[ "DUF4177" ]

[ 3438 ]

1

[]

0

[]

0

[ "PUB00151928" ]

[ "23155385" ]

[ "Definition of the σ(W) regulon of Bacillus subtilis in the absence of stress." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanobacteriota", "Opisthokonta", "unclassified sequences" ]

[ 3159, 19, 201, 4, 55 ]

5

[]

0

true

Family

YjzH-like

1

IPR025235

25,235

Domain of unknown function DUF4178

DUF4178

Domain

3,436

false

This is a domain of unknown function, mainly found in bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF13785" ]

[ "DUF4178" ]

[ 3436 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4, 3413, 4, 15 ]

4

[]

0

true

Domain

Domain of unknown function DUF4178

DUF4178

6

IPR025236

25,236

SR1 protein

SR1P

Family

918

false

This family of proteins is encoded by the dual function SR1 RNA. SR1 is a sRNA which regulates arginine metabolism [ ], it also encodes a short protein that binds to glyceraldehyde-3-phosphate dehydrogenase (GapA) and stabilises the gapA operon mRNAs [ ].

[]

0

[ "PFAM" ]

[ "PF13790" ]

[ "SR1P" ]

[ 918 ]

1

[]

0

[]

0

[ "PUB00075682", "PUB00075683" ]

[ "17020585", "20444087" ]

[ "The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism.", "A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon." ]

[ 2006, 2010 ]

2

[]

0

null

[ "Bacteria" ]

[ 918 ]

1

[]

0

true

Family

SR1 protein

SR1P

9

IPR025238

25,238

Protein of unknown function DUF4184

DUF4184

Family

2,812

false

These proteins of unknown function contain several highly conserved histidines.

[]

0

[ "PFAM" ]

[ "PF13803" ]

[ "DUF4184" ]

[ 2812 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "marine sediment metagenome" ]

[ 5, 2795, 12 ]

3

[]

0

true

Family

Protein of unknown function DUF4184

DUF4184

6

IPR025239

25,239

Domain of unknown function DUF4187

DUF4187

Domain

4,951

false

This short, cysteine-rich domain is often found C-terminal to a G-patch domain.

[]

0

[ "PFAM", "SMART" ]

[ "PF13821", "SM01173" ]

[ "DUF4187", "DUF4187" ]

[ 4747, 4928 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4951 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 3, 2, 2, 2, 2, 1, 1, 8 ]

12

true

Domain

Domain of unknown function DUF4187

DUF4187

8

IPR025240

25,240

Domain of unknown function DUF4189

DUF4189

Domain

2,720

false

This domain of unknown function contains six well-conserved cysteine residues.

[]

0

[ "PFAM" ]

[ "PF13827" ]

[ "DUF4189" ]

[ 2720 ]

1

[]

0

[ "7nhz" ]

1

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2705, 11, 4 ]

3

[]

0

true

Domain

Domain of unknown function DUF4189

DUF4189

2

IPR025241

25,241

Domain of unknown function DUF4190

DUF4190

Domain

9,136

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF13828" ]

[ "DUF4190" ]

[ 9136 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Siphoviridae sp. ctrgt10", "metagenomes" ]

[ 8987, 6, 4, 1, 138 ]

5

[]

0

true

Domain

Domain of unknown function DUF4190

DUF4190

2

IPR025242

25,242

Protein of unknown function DUF4193

DUF4193

Family

5,201

false

These functionally uncharacterised proteins contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.

[]

0

[ "PFAM" ]

[ "PF13834" ]

[ "DUF4193" ]

[ 5201 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 5077, 124 ]

2

[]

0

true

Family

Protein of unknown function DUF4193

DUF4193

9

IPR025243

25,243

Domain of unknown function DUF4195

DUF4195

Domain

1,608

false

This domain is found at the N terminus of a number of proteins that carry PHD-like zinc-finger domains.

[]

0

[ "PFAM" ]

[ "PF13836" ]

[ "DUF4195" ]

[ 1608 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 1608 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 15, 14 ]

3

true

Domain

Domain of unknown function DUF4195

DUF4195

8

IPR025245

25,245

Protein of unknown function DUF4197

DUF4197

Family

4,287

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF13852" ]

[ "DUF4197" ]

[ 4287 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4228, 20, 39 ]

3

[]

0

true

Family

Protein of unknown function DUF4197

DUF4197

8

IPR025246

25,246

Transposase IS30-like HTH domain

IS30-like_HTH

Domain

19,300

false

This helix-turn-helix domain is found in some transposases and is likely to be DNA-binding.

[]

0

[ "PFAM" ]

[ "PF13936" ]

[ "HTH_38" ]

[ 19300 ]

1

[]

0

[ "2lvs" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 66, 17073, 1695, 232, 234 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Transposase IS30-like HTH domain

IS30-like_HTH

2

IPR025247

25,247

Type II methyltransferase M.EcoRI-like

EcoRI-like_methylase

Family

1,070

false

Type II methyltransferase M.EcoRI recognises the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease [ ]. This entry also includes Type II methyltransferases M.MgeORF184P and M.MpnI from the human pathogens Mycoplasma genitali...

[]

0

[ "PFAM" ]

[ "PF13651" ]

[ "EcoRI_methylase" ]

[ 1070 ]

1

[ "EC" ]

[ "2.1.1.72" ]

[ "EC:2.1.1.72" ]

1

[]

0

[ "PUB00099965", "PUB00100337" ]

[ "12654995", "23300489" ]

[ "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.", "Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution." ]

[ 2003, 2013 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "Plasmid P6", "Protostomia", "Viruses", "unclassified sequences" ]

[ 1028, 4, 1, 4, 14, 19 ]

6

[]

0

true

Family

Type II methyltransferase M.EcoRI-like

EcoRI-like_methylase

7

IPR025248

25,248

Domain of unknown function DUF4007

DUF4007

Domain

1,194

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF13182" ]

[ "DUF4007" ]

[ 1194 ]

1

[]

0

[ "6juf", "6lb9" ]

2

[]

0

[]

0

null

[ "Bacteria", "Cenarchaeum symbiosum (strain A)", "Eukaryota", "Siphoviridae sp. ctg0K17", "metagenomes" ]

[ 1159, 1, 3, 1, 30 ]

5

[]

0

true

Domain

Domain of unknown function DUF4007

DUF4007

3

IPR025249

25,249

Transcription factor NusA, first KH domain

TF_NusA_KH_1st

Domain

25,366

false

This entry represents the first K homology (KH) domain found in NusA transcription termination factors. KH domains bind RNA and can function in RNA recognition [ ]. NusA is involved in transcriptional pausing, termination and anti-termination. NusA from Thermotoga maritima contains an N-terminal domain and three RNA-bi...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF13184" ]

[ "KH_NusA_1st" ]

[ 25366 ]

1

[]

0

[ "1hh2", "1k0r", "1l2f", "2asb", "2atw", "4mtn", "5lm7", "5lm9", "5ms0", "6flq", "6gov", "6j9e", "6tqn", "6tqo", "6x6t", "6x7f", "6x7k", "6x9q", "6xas", "6xav", "6xdq", "6z9p", "6z9q", "6z9r", "6z9s", "6z9t", "7adb", "7adc", "7add", "7ade", "7py3", "7py5"...

63

[ "PUB00013514", "PUB00026604", "PUB00026894", "PUB00035579" ]

[ "11040219", "11743725", "14621988", "17437720" ]

[ "The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA.", "Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution.", "Crystal structure of NusA from Thermotoga maritima and functional implication of the N-terminal do...

[ 2000, 2001, 2003, 2007 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23, 24675, 115, 553 ]

4

[ "Escherichia coli (strain K12)", "Homo sapiens" ]

[ 1, 1 ]

2

true

Domain

Transcription factor NusA, first KH domain

TF_NusA_KH_1st

4

IPR025250

25,250

Protein of unknown function DUF4199

DUF4199

Family

4,671

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF13858" ]

[ "DUF4199" ]

[ 4671 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4612, 5, 54 ]

3

[]

0

true

Family

Protein of unknown function DUF4199

DUF4199

9

IPR025251

25,251

Domain of unknown function DUF4213

DUF4213

Domain

1,207

false

This domain of unknown function has an enolase N-terminal domain-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the N terminus of proteins containing . The structure of , , suggests that the whole protein has this enolase N-terminal-l...

[]

0

[ "PFAM" ]

[ "PF13938" ]

[ "DUF4213" ]

[ 1207 ]

1

[]

0

[ "3l5o", "3npg" ]

2

[ "PUB00075371" ]

[ "20944207" ]

[ "Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation." ]

[ 2010 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 286, 875, 46 ]

3

[]

0

true

Domain

Domain of unknown function DUF4213

DUF4213

9

IPR025252

25,252

Domain of unknown function DUF4200

DUF4200

Domain

4,677

false

This entry represents a coiled-coil domain. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF13863" ]

[ "DUF4200" ]

[ 4677 ]

1

[]

0

[ "8glv", "8j07", "9e5c", "9fqr" ]

4

[]

0

[]

0

null

[ "Eukaryota", "Wolbachia endosymbiont of Polyergus mexicanus" ]

[ 4676, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 5, 6, 16 ]

5

true

Domain

Domain of unknown function DUF4200

DUF4200

5

IPR025253

25,253

Type I toxin-antitoxin system, toxin Ldr

Toxin_Ldr

Family

1,014

false

This family includes the Ldr (long direct repeat) toxins. In Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and LdrD. These toxins inhibit cell growth, decrease cell viability and cause nucleoid condensation. They are part of the type I toxin antitoxin (TA) system, where expression of the proteinaceous to...

[]

0

[ "PFAM" ]

[ "PF13940" ]

[ "Ldr_toxin" ]

[ 1014 ]

1

[ "GP" ]

[ "GenProp1091" ]

[ "GP:GenProp1091" ]

1

[ "5lbj" ]

1

[ "PUB00057321" ]

[ "12123448" ]

[ "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "organismal metagenomes" ]

[ 1011, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Family

Type I toxin-antitoxin system, toxin Ldr

Toxin_Ldr

9

IPR025254

25,254

CCDC113/CCDC96, coiled-coil

CCDC113/CCDC96_CC

Domain

2,919

false

This entry represents the coiled-coil region of coiled-coil domain-containing protein 113 (CCDC113, also known as cilia- and flagella-associated protein 263, CFAP263) and coiled-coil domain-containing protein 96 (CCDC96, also known as cilia- and flagella-associated protein 184, CFAP184). These proteins form a complex a...

[]

0

[ "PFAM" ]

[ "PF13870" ]

[ "CCDC113_CCDC96_CC" ]

[ 2919 ]

1

[]

0

[ "8glv", "8j07", "8tek", "8th8", "8tid", "9e5c", "9fqr" ]

7

[ "PUB00153410" ]

[ "33661892" ]

[ "Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link." ]

[ 2021 ]

1

[]

0

null

[ "Archaea", "Eukaryota" ]

[ 2, 2917 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 20, 2, 3, 5 ]

5

true

Domain

CCDC113/CCDC96, coiled-coil

CCDC113/CCDC96_CC

8

IPR025255

25,255

Protein of unknown function DUF4202

DUF4202

Family

2,497

false

The function of these proteins is unknown, although some are incorrectly annotated as glutamyl tRNA synthetases. There are two conserved sequence motifs: LED and KMS.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF13875", "PTHR41729" ]

[ "DUF4202", "" ]

[ 2495, 2339 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 9, 1421, 1008, 59 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF4202

DUF4202

1

IPR025256

25,256

TM7S3/TM198-like domain

TM7S3/TM198-like_dom

Domain

6,960

false

This domain is found at the C-terminal end of human Transmembrane 7 superfamily member 3 (TM7SF3), towards the N terminus of human Transmembrane protein 198 (TM198), and in similar proteins mainly found in animal, fungi and bacteria. TM7SF3 is involved in the inhibition of cytokine-induced death of pancreatic beta cell...

[]

0

[ "PFAM" ]

[ "PF13886" ]

[ "TM7S3_TM198" ]

[ 6960 ]

1

[]

0

[]

0

[ "PUB00090731", "PUB00093040", "PUB00093041" ]

[ "21536646", "27740623", "21853325" ]

[ "Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.", "TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.", "An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a sev...

[ 2011, 2017, 2011 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 175, 6768, 10, 7 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 5, 3, 11, 6, 1, 8 ]

6

true

Domain

TM7S3/TM198-like domain

TM7S3/TM198-like_dom

4

IPR025257

25,257

Deubiquitinating enzyme MINDY-3/4, conserved domain

MINDY-3/4_CD

Domain

5,648

false

This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4. Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitylation. MINDY-3/4 belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase fa...

[]

0

[ "PFAM", "SMART" ]

[ "PF13898", "SM01174" ]

[ "MINDY-3_4_CD", "DUF4205" ]

[ 5638, 5218 ]

2

[ "EC" ]

[ "3.4.19.12" ]

[ "EC:3.4.19.12" ]

1

[]

0

[ "PUB00081935" ]

[ "27292798" ]

[ "MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5648 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 17, 7, 8, 13, 4, 11, 14 ]

8

true

Domain

Deubiquitinating enzyme MINDY-3/4, conserved domain

MINDY-3/4_CD

9

IPR025259

25,259

Coiled-coil domain-containing protein 34/181

CCDC34/181

Domain

1,381

false

This domain can be found in animal CCDC34 and CCDC181 proteins. CCDC34 promotes cell proliferation and invasive properties in human cancer [ ]. CCDC181 is a microtubule-binding protein that may play a role in mediating ciliary motility [ ].

[]

0

[ "PFAM" ]

[ "PF13904" ]

[ "CCDC34" ]

[ 1381 ]

1

[]

0

[]

0

[ "PUB00098573", "PUB00098574" ]

[ "29257799", "28283191" ]

[ "Expression of Coiled-Coil Domain Containing 34 (CCDC34) and its Prognostic Significance in Pancreatic Adenocarcinoma.", "Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia." ]

[ 2017, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1381 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 27, 1, 4, 4 ]

5

true

Domain

Coiled-coil domain-containing protein 34/181

CCDC34/181

8

IPR025260

25,260

Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain

CHD1-like_C

Domain

6,978

false

This entry represents a domain found at the C terminus of chromodomain-helicase-DNA-binding proteins, including Chromodomain-helicase-DNA-binding protein 1 from human (CHD1), an ATP-dependent chromatin-remodeling factor which acts as substrate recognition component of the transcription regulatory histone acetylation (H...

[]

0

[ "PFAM", "SMART" ]

[ "PF13907", "SM01176" ]

[ "CHD1-like_C", "DUF4208" ]

[ 6867, 6909 ]

2

[ "EC", "METACYC", "REACTOME" ]

[ "3.6.4.-", "PWY-7250", "R-HSA-9018519" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250", "REACTOME:R-HSA-9018519" ]

3

[ "2n39", "5o9g", "6g0l", "7nkx", "9gd1", "9gd2", "9gd3" ]

7

[ "PUB00091268", "PUB00100856", "PUB00100857", "PUB00101868" ]

[ "27591891", "18042460", "28866611", "33566224" ]

[ "The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.", "Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.", "Missense variants in the chromatin remodeler CHD1 are ass...

[ 2016, 2007, 2018, 2021 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6978 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 10, 6, 6, 4, 1, 3, 13, 1, 1, 68 ]

12

true

Domain

Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain

CHD1-like_C

7

IPR025261

25,261

Atos-like, conserved domain

Atos-like_cons_dom

Domain

5,187

false

This domain is found in the central region of Drosophila Atos, its homologues from mammals, Atos homologue protein A/B (ATOSA/B, formerly known as FAM241) and S.pombe C3H8.04 (SPACC3H8.04), the orthologue of human ATOSA which, from a high-throughput knockout screening, was identified as a protein required for meiotic c...

[]

0

[ "PFAM", "SMART" ]

[ "PF13915", "SM01177" ]

[ "DUF4210", "DUF4210" ]

[ 4437, 5178 ]

2

[]

0

[]

0

[ "PUB00044235", "PUB00101182" ]

[ "16169489", "35319107" ]

[ "Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.", "Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila." ]

[ 2005, 2022 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 5185 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 14, 18, 2, 4, 4, 14, 7, 1, 17 ]

9

true

Domain

Atos-like, conserved domain

Atos-like_cons_dom

9