interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051376 | 51,376 | Pre-mRNA-splicing factor CWC25 | CWC25_splicing_factor | Family | 4,217 | true | false | The CWC25 family comprises proteins that are involved in the process of pre-mRNA splicing. Members of the CWC25 family are recognized as components of the spliceosome, a complex molecular machine responsible for the removal of introns from a pre-mRNA transcript and the ligation of the remaining exons to form a mature m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16196"
] | [
"CWC25_splicing_factor"
] | [
4217
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163",
"R-SPO-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-SPO-72163"
] | 3 | [
"5gmk",
"5lj3",
"5lj5",
"5yzg",
"6zym",
"8i0w"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4217
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
1,
1,
5,
4,
1,
4,
4,
1,
1,
7
] | 12 | true | Family | Pre-mRNA-splicing factor CWC25 | Pre-mRNA-splicing factor CWC25 | CWC25_splicing_factor | 6 |
IPR051378 | 51,378 | Cell-to-cell trafficking and antifungal protein | Cell2Cell_Antifungal | Family | 5,091 | true | false | This family of proteins is involved in modulating cell-to-cell trafficking and plays a role in plant innate immunity. Members of this family are implicated in systemic acquired resistance, a defense mechanism that utilizes signaling molecules such as azelaic acid, glycerol-3-phosphate, and salicylic acid. Some proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32080"
] | [
"Cell2Cell_Antifungal"
] | [
5091
] | 1 | [] | [] | [] | 0 | [
"3a2e",
"4xre",
"6gre",
"6grf"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
5091
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
39,
21,
26
] | 3 | true | Family | Cell-to-cell trafficking and antifungal protein | Cell-to-cell trafficking and antifungal protein | Cell2Cell_Antifungal | 8 |
IPR051379 | 51,379 | C-type Lectin Receptor Immune Modulators | C-type_Lectin_Receptor_IMM | Family | 3,265 | true | false | The protein family is composed of C-type lectin domain-containing receptors with diverse roles in the immune system. Members are involved in pathogen recognition, mediating immune cell interactions, and antigen presentation. They recognize various molecular patterns, including those from bacteria, fungi, and damaged ce... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46746"
] | [
"C-type_Lectin_Receptor_IMM"
] | [
3265
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1236978",
"R-CEL-446203",
"R-CEL-5621480",
"R-CEL-6798695",
"R-HSA-198933",
"R-HSA-5621480",
"R-MMU-5621575",
"R-MMU-8851680"
] | [
"REACTOME:R-CEL-1236978",
"REACTOME:R-CEL-446203",
"REACTOME:R-CEL-5621480",
"REACTOME:R-CEL-6798695",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-5621480",
"REACTOME:R-MMU-5621575",
"REACTOME:R-MMU-8851680"
] | 8 | [
"3zhg",
"4caj",
"4iop",
"8qmd"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Echinimonas agarilytica",
"Eukaryota"
] | [
1,
3264
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
10,
10,
15
] | 5 | true | Family | C-type Lectin Receptor Immune Modulators | C-type Lectin Receptor Immune Modulators | C-type_Lectin_Receptor_IMM | 1 |
IPR051380 | 51,380 | Fungal pH-response regulator palI/RIM9 | pH-response_reg_palI/RIM9 | Family | 3,853 | true | false | The palI/RIM9 family is involved in the regulation of pH response in various fungi. Members of this family are essential for the proteolytic cleavage of transcription factors, such as RIM101 or its homologs, which is a crucial step in the adaptation to alkaline environments. This cleavage event activates the transcript... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28013"
] | [
"pH-response_reg_palI/RIM9"
] | [
3853
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3853
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
3,
2
] | 3 | true | Family | Fungal pH-response regulator palI/RIM9 | Fungal pH-response regulator palI/RIM9 | pH-response_reg_palI/RIM9 | 9 |
IPR051381 | 51,381 | cAMP-responsive element-binding ATF subfamily | CREB_ATF_subfamily | Family | 3,516 | true | false | This family of proteins includes transcriptional activators that are involved in the unfolded protein response (UPR) and cellular stress responses. They bind to specific DNA elements such as the cAMP response element (CRE) and the unfolded protein response element (UPRE), thereby regulating gene expression. These prote... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45996"
] | [
"CREB_ATF_subfamily"
] | [
3516
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8874211",
"R-CEL-8874211",
"R-DRE-8874211",
"R-HSA-8874211",
"R-HSA-8963889",
"R-MMU-8874211",
"R-RNO-8874211"
] | [
"REACTOME:R-BTA-8874211",
"REACTOME:R-CEL-8874211",
"REACTOME:R-DRE-8874211",
"REACTOME:R-HSA-8874211",
"REACTOME:R-HSA-8963889",
"REACTOME:R-MMU-8874211",
"REACTOME:R-RNO-8874211"
] | 7 | [
"6iak"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3516
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
11,
5,
9
] | 5 | true | Family | cAMP-responsive element-binding ATF subfamily | cAMP-responsive element-binding ATF subfamily | CREB_ATF_subfamily | 4 |
IPR051382 | 51,382 | Cytochrome P450 Amino Acid/Fatty Acid Hydroxylases | CYP450_AA/FA_Hydroxylases | Family | 431 | true | false | The Cytochrome P450 family is involved in diverse biosynthetic processes, including the production of defensive cyanogenic glycosides, glucosinolates, and other specialized metabolites. Members of the family catalyze the N-hydroxylation of amino acids such as phenylalanine, isoleucine, valine, and tryptophan, convertin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47949"
] | [
"CYP450_AA/FA_Hydroxylases"
] | [
431
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
431
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
6,
5
] | 2 | true | Family | Cytochrome P450 Amino Acid/Fatty Acid Hydroxylases | Cytochrome P450 Amino Acid/Fatty Acid Hydroxylases | CYP450_AA/FA_Hydroxylases | 1 |
IPR051383 | 51,383 | Cytochrome c oxidase assembly protein COX19 | COX19 | Family | 2,773 | true | false | This family of proteins is involved in the assembly of mitochondrial cytochrome c oxidase, a key component of the respiratory chain. Members of this family may also play a role in the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A, which is important for regulating cellular copper homeos... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21107"
] | [
"COX19"
] | [
2773
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9864848",
"R-HSA-1268020",
"R-HSA-9864848",
"R-MMU-9864848"
] | [
"REACTOME:R-BTA-9864848",
"REACTOME:R-HSA-1268020",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-9864848"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2773
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
1,
2,
3,
1,
5,
1,
1
] | 9 | true | Family | Cytochrome c oxidase assembly protein COX19 | Cytochrome c oxidase assembly protein COX19 | COX19 | 2 |
IPR051384 | 51,384 | Methuselah G-protein coupled receptor | Mth_GPCR | Family | 2,246 | true | false | The Mth G-protein coupled receptor family is involved in key physiological processes such as biological aging and stress response. These receptors are essential for adult survival across various species. In Drosophila, the Mth receptors play a critical role in the nervous system by up-regulating neurotransmitter exocyt... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47154"
] | [
"Mth_GPCR"
] | [
2246
] | 1 | [] | [] | [] | 0 | [
"1fjr",
"2pzx"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses"
] | [
2241,
5
] | 2 | [
"Drosophila melanogaster"
] | [
32
] | 1 | true | Family | Methuselah G-protein coupled receptor | Methuselah G-protein coupled receptor | Mth_GPCR | 4 |
IPR051385 | 51,385 | Ceramide-binding SVF1-like | Svf1-like | Family | 1,908 | false | false | This entry represents a family of stress survival proteins, such as survival factor 1 (Svf1). The protein Svf1 is required for yeast survival under conditions of oxidative stress, including cold stress [ ]. Cells deficient in Svf1 have increased levels of reactive oxygen species (ROS) under certain conditions. Svf1 aff... | [
"GO:0120013"
] | [
"lipid transfer activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR47107"
] | [
""
] | [
1908
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00033375",
"PUB00074949",
"PUB00161767"
] | [
"16034825",
"17057230",
"38525852"
] | [
"Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae.",
"SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.",
"Recent Advances on Small-Molecule Inhibitors of Lipocalin-like Proteins."... | [
2005,
2007,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Bradymonadaceae",
"Eukaryota"
] | [
2,
1906
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
3,
2
] | 3 | true | Family | Ceramide-binding SVF1-like | Ceramide-binding SVF1-like | Svf1-like | 8 |
IPR051387 | 51,387 | Barrier-to-autointegration factor | BAF | Family | 1,950 | true | false | The BAF family comprises non-specific DNA-binding proteins with key roles in nuclear dynamics and cellular defense mechanisms. Members of the BAF family are involved in mitotic nuclear reassembly, chromatin organization, and DNA damage response. They contain helix-hairpin-helix (HhH) structural motifs, allowing them to... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47507"
] | [
"BAF"
] | [
1950
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2980766",
"R-BTA-2995383",
"R-CEL-2995383",
"R-DME-2995383",
"R-DRE-2995383",
"R-HSA-162592",
"R-HSA-164843",
"R-HSA-175567",
"R-HSA-177539",
"R-HSA-180689",
"R-HSA-180910",
"R-HSA-2980766",
"R-HSA-2995383",
"R-MMU-2980766",
"R-MMU-2995383",
"R-RNO-2980766",
"R-RNO-2995383"
] | [
"REACTOME:R-BTA-2980766",
"REACTOME:R-BTA-2995383",
"REACTOME:R-CEL-2995383",
"REACTOME:R-DME-2995383",
"REACTOME:R-DRE-2995383",
"REACTOME:R-HSA-162592",
"REACTOME:R-HSA-164843",
"REACTOME:R-HSA-175567",
"REACTOME:R-HSA-177539",
"REACTOME:R-HSA-180689",
"REACTOME:R-HSA-180910",
"REACTOME:R-HS... | 17 | [
"1ci4",
"1qck",
"2bzf",
"2ezx",
"2ezy",
"2ezz",
"2odg",
"6ghd",
"6rpr",
"6unt",
"6ure",
"6urj",
"6urk",
"6url",
"6urn",
"6urr",
"6urz",
"6us0",
"6us1",
"6us7",
"6usb",
"6usd",
"6usi",
"7abm",
"7ndy",
"7z21",
"9j8m",
"9j8n",
"9j8o"
] | 29 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"organismal metagenomes"
] | [
1948,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
4,
2,
2
] | 6 | true | Family | Barrier-to-autointegration factor | Barrier-to-autointegration factor | BAF | 8 |
IPR051388 | 51,388 | Serine protease inhibitor and venom toxin | Serpin_venom_toxin | Family | 1,465 | true | false | This family of proteins includes serine protease inhibitors with diverse biological functions. Members are involved in male reproduction and fertility, modulating sperm motility, and providing antimicrobial protection for spermatozoa. Some family members are toxins from venomous species, inhibiting serine proteases and... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46751"
] | [
"Serpin_venom_toxin"
] | [
1465
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803157",
"R-MMU-6803157",
"R-RNO-6803157"
] | [
"REACTOME:R-HSA-6803157",
"REACTOME:R-MMU-6803157",
"REACTOME:R-RNO-6803157"
] | 3 | [
"1bun"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Sorangium"
] | [
1459,
6
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
8,
9,
3,
9
] | 5 | true | Family | Serine protease inhibitor and venom toxin | Serine protease inhibitor and venom toxin | Serpin_venom_toxin | 7 |
IPR051389 | 51,389 | Cytochrome c oxidase subunit VIc | Cytochrome_c_oxidase_VIc | Family | 1,569 | false | false | Cytochrome c oxidase (CcO; ), a 13 subunit complex, is the terminal oxidase in the mitochondrial electron transport chain. Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water [ , ]. This entry contains of cytochrome c oxidase subunit VIc (also known as Cytochro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48416"
] | [
""
] | [
1569
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5628897",
"R-BTA-611105",
"R-BTA-9707564",
"R-BTA-9864848",
"R-HSA-5628897",
"R-HSA-611105",
"R-HSA-9707564",
"R-HSA-9864848",
"R-MMU-5628897",
"R-MMU-611105",
"R-MMU-9707564",
"R-MMU-9864848",
"R-RNO-5628897",
"R-RNO-611105",
"R-RNO-9707564",
"R-RNO-9864848"
] | [
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-9707564",
"REACTOME:R-BTA-9864848",
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9707564",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-5628897",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-9707564",
"REACTOME:R... | 16 | [
"1occ",
"1oco",
"1ocr",
"1ocz",
"1v54",
"1v55",
"2dyr",
"2dys",
"2eij",
"2eik",
"2eil",
"2eim",
"2ein",
"2occ",
"2y69",
"2ybb",
"2zxw",
"3abk",
"3abl",
"3abm",
"3ag1",
"3ag2",
"3ag3",
"3ag4",
"3asn",
"3aso",
"3wg7",
"3x2q",
"5b1a",
"5b1b",
"5b3s",
"5gpn"... | 109 | [
"PUB00079538",
"PUB00079540",
"PUB00080112"
] | [
"11035249",
"16760263",
"12973739"
] | [
"Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase.",
"Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process.",
"Mitochondrial proteome: altered cytochrome c oxidase subunit levels in prostate cancer."
] | [
2000,
2006,
2003
] | 3 | [
"IPR034884"
] | [] | 1 | 0 | 1 | [
"Metazoa"
] | [
1569
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
4,
2,
1,
6
] | 6 | true | Family | Cytochrome c oxidase subunit VIc | Cytochrome c oxidase subunit VIc | Cytochrome_c_oxidase_VIc | 1 |
IPR051390 | 51,390 | Biogenesis of lysosome-related organelles complex 1 subunit KXD1 | BLOC-1_subunit_KXD1 | Family | 1,147 | true | false | The KXD1 family comprises proteins that are integral components of the biogenesis of lysosome-related organelles complex-1 (BLOC-1). Members of the KXD1 family are involved in the crucial process of endosomal cargo sorting, which is essential for the proper functioning and distribution of materials to lysosome-related ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37787"
] | [
"BLOC-1_subunit_KXD1"
] | [
1147
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
1147
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Biogenesis of lysosome-related organelles complex 1 subunit KXD1 | Biogenesis of lysosome-related organelles complex 1 subunit KXD1 | BLOC-1_subunit_KXD1 | 9 |
IPR051391 | 51,391 | Protease inhibitor I20 (potato type II proteinase inhibitor) | Protease_inhibitor_I20 | Family | 869 | true | false | The protease inhibitor I20 (potato type II proteinase inhibitor) family consists of proteins that function primarily as inhibitors of proteolytic enzymes such as trypsin and chymotrypsin. Members of this family are potent inhibitors of trypsin, with varying degrees of effectiveness against chymotrypsin. Some members do... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33832"
] | [
"Protease_inhibitor_I20"
] | [
869
] | 1 | [] | [] | [] | 0 | [
"1ce3",
"1fyb",
"1oyv",
"1pju",
"1tih",
"1ytp",
"2jyy",
"2jzm",
"4sgb",
"5zfo"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tracheophyta"
] | [
869
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
6,
5
] | 3 | true | Family | Protease inhibitor I20 (potato type II proteinase inhibitor) | Protease inhibitor I20 (potato type II proteinase inhibitor) | Protease_inhibitor_I20 | 4 |
IPR051393 | 51,393 | ABC transporter permease component | ABC_transporter_permease | Family | 96,090 | true | false | This family of proteins is involved in the transport of various substrates across cellular membranes. Members of this family are typically part of ATP-binding cassette (ABC) transporter complexes, which are binding-protein-dependent systems. These proteins are likely responsible for the translocation of substrates such... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30193"
] | [
"ABC_transporter_permease"
] | [
96090
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
883,
94389,
40,
778
] | 4 | [] | [] | 0 | true | Family | ABC transporter permease component | ABC transporter permease component | ABC_transporter_permease | 5 |
IPR051394 | 51,394 | Glutamate Synthase | Glutamate_Synthase | Family | 20,716 | true | false | The glutamate synthase family is involved in the biosynthesis of glutamate, a critical amino acid for protein synthesis and a key metabolite in nitrogen metabolism. Members of this family are responsible for the conversion of L-glutamine and 2-oxoglutarate to L-glutamate, which is an alternative pathway to the one cata... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43100"
] | [
"Glutamate_Synthase"
] | [
20716
] | 1 | [
"EC",
"METACYC"
] | [
"1.4.1.14",
"PWY-6963"
] | [
"EC:1.4.1.14",
"METACYC:PWY-6963"
] | 2 | [
"7mfm",
"7mft"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"CRESS virus sp. ctBnw2",
"Eukaryota",
"metagenomes"
] | [
51,
14927,
1,
4942,
795
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 248... | [
6,
2,
4,
1,
7,
1,
1,
87
] | 8 | true | Family | Glutamate Synthase | Glutamate Synthase | Glutamate_Synthase | 7 |
IPR051395 | 51,395 | Cytochrome c-dependent Peroxidase and MauG | Cytochrome_c_Peroxidase/MauG | Family | 26,065 | true | false | The protein family encompasses enzymes with peroxidase activity, primarily reducing hydrogen peroxide (H2O2) to water using reduced cytochrome c as an electron donor. Members are involved in various biological processes, including iodate respiration, where they play a role in detoxifying H2O2 produced by iodate reducta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30600"
] | [
"Cytochrome_c_Peroxidase/MauG"
] | [
26065
] | 1 | [] | [] | [] | 0 | [
"1eb7",
"1iqc",
"1nml",
"1rz5",
"1rz6",
"1zzh",
"2c1u",
"2c1v",
"2vhd",
"3hq6",
"3hq7",
"3hq8",
"3hq9",
"3l4m",
"3l4o",
"3o5c",
"3orv",
"3pxs",
"3pxt",
"3pxw",
"3rlm",
"3rmz",
"3rn0",
"3rn1",
"3sjl",
"3sle",
"3svw",
"3sws",
"3sxt",
"4aal",
"4aam",
"4aan"... | 56 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
25708,
26,
37,
294
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cytochrome c-dependent Peroxidase and MauG | Cytochrome c-dependent Peroxidase and MauG | Cytochrome_c_Peroxidase/MauG | 7 |
IPR051396 | 51,396 | Bacterial Antiviral Defense Nuclease | Bact_Antivir_Def_Nuclease | Family | 28,864 | true | false | The protein family is involved in antiviral defense mechanisms across various bacterial species. Members of the family function as components of complex systems that confer resistance to bacteriophages. These systems often include an ATPase component, a reverse transcriptase, a non-coding RNA, and a nuclease. The nucle... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43581"
] | [
"Bact_Antivir_Def_Nuclease"
] | [
28864
] | 1 | [] | [] | [] | 0 | [
"6p74",
"8j4t",
"8jq9",
"8jqb",
"8jqc",
"8sm3",
"8tjy",
"8tk0",
"8tk1",
"8ux9",
"8v45",
"8v46",
"8v47",
"8v48",
"8v49",
"8wy4",
"8wy5",
"8x51",
"8x5i",
"8x5n",
"9nnb",
"9nnk",
"9p4j",
"9p4k"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
731,
27539,
109,
30,
455
] | 5 | [] | [] | 0 | true | Family | Bacterial Antiviral Defense Nuclease | Bacterial Antiviral Defense Nuclease | Bact_Antivir_Def_Nuclease | 8 |
IPR051397 | 51,397 | Zinc-containing alcohol dehydrogenase-like protein | Zn-ADH-like_protein | Family | 35,815 | true | false | This family of proteins includes enzymes that are primarily involved in redox reactions, specifically the reduction of quinones and other related compounds. Members of this family are characterized by the presence of a zinc-binding motif, which is typical of zinc-containing alcohol dehydrogenase enzymes. These proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43677"
] | [
"Zn-ADH-like_protein"
] | [
35815
] | 1 | [] | [] | [] | 0 | [
"1iyz",
"1iz0",
"1o89",
"1o8c",
"1tt7",
"1xa0",
"1y9e",
"2c0c",
"2cf2",
"2wek",
"2x1h",
"2x7h",
"3nx4",
"4eye",
"4jxk",
"5gxe",
"5gxf",
"7zej"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
27427,
8023,
28,
337
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
4,
9,
1,
7,
11,
31
] | 8 | true | Family | Zinc-containing alcohol dehydrogenase-like protein | Zinc-containing alcohol dehydrogenase-like protein | Zn-ADH-like_protein | 8 |
IPR051400 | 51,400 | HAD-like hydrolase superfamily enzymes | HAD-like_hydrolase | Family | 19,460 | true | false | This family of proteins includes enzymes that are part of the HAD-like hydrolase superfamily. Members of this family are involved in various biochemical processes, such as the dephosphorylation of different substrates including D,L-glyceraldehyde 3-phosphate, 5-amino-6-(5-phospho-D-ribitylamino)uracil, flavin mononucle... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46470"
] | [
"HAD-like_hydrolase"
] | [
19460
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3",
"R-HSA-4085001",
"R-MMU-4085001",
"R-RNO-4085001"
] | [
"EC:3.1.3",
"REACTOME:R-HSA-4085001",
"REACTOME:R-MMU-4085001",
"REACTOME:R-RNO-4085001"
] | 4 | [
"2gfh",
"2hoq",
"2w4m",
"3ib6",
"3vay",
"4knv",
"4knw",
"4ygq",
"4ygr",
"4ygs",
"6q7p",
"6q7q",
"6q7r",
"6z1l",
"7o1d",
"8bp0"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1405,
16159,
1642,
2,
252
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
1,
1,
5
] | 6 | true | Family | HAD-like hydrolase superfamily enzymes | HAD-like hydrolase superfamily enzymes | HAD-like_hydrolase | 2 |
IPR051401 | 51,401 | Bacterial Cell Wall Glycosylation GtrA | GtrA_CellWall_Glycosyl | Family | 23,791 | true | false | The GtrA family proteins are involved in various glycosylation processes essential for bacterial cell wall integrity and function. Members of this family participate in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane, a critical step in O antigen modification. Some proteins within the Gt... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38459"
] | [
"GtrA_CellWall_Glycosyl"
] | [
23791
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
601,
22954,
16,
4,
216
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterial Cell Wall Glycosylation GtrA | Bacterial Cell Wall Glycosylation GtrA | GtrA_CellWall_Glycosyl | 8 |
IPR051402 | 51,402 | Ketopantoate Reductase-Related | KPR-Related | Family | 20,944 | true | false | This family of proteins includes enzymes that are primarily involved in the biosynthesis of pantothenic acid, a precursor for the synthesis of coenzyme A. Members of this family are known to catalyze the NAD(P)H-dependent reduction of ketopantoate to pantoic acid, which is a key step in the production of pantothenate. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21708"
] | [
"KPR-Related"
] | [
20944
] | 1 | [] | [] | [] | 0 | [
"2qyt",
"3g17",
"3ghy",
"3hn2",
"3i83",
"4s3m",
"4yca",
"8iwg",
"8iwq",
"8ix9",
"8ixh",
"8ixm"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
182,
14880,
5624,
258
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
5,
4,
2
] | 3 | true | Family | Ketopantoate Reductase-Related | Ketopantoate Reductase-Related | KPR-Related | 2 |
IPR051403 | 51,403 | NosZ/Cytochrome c oxidase subunit 2 | NosZ/Cyto_c_oxidase_sub2 | Family | 9,603 | true | false | The NosZ/Cytochrome c oxidase subunit 2 family includes enzymes that play a crucial role in bacterial respiratory systems under anaerobic conditions. Nitrous-oxide reductase, a member of this family, is responsible for the reduction of nitrous oxide, a potent greenhouse gas, during the final step of the denitrification... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42838"
] | [
"NosZ/Cyto_c_oxidase_sub2"
] | [
9603
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.7.2.4",
"PWY-6748",
"PWY-7084"
] | [
"EC:1.7.2.4",
"METACYC:PWY-6748",
"METACYC:PWY-7084"
] | 3 | [
"1ehk",
"1fwx",
"1qni",
"1xme",
"2cua",
"2fwl",
"2iwf",
"2iwk",
"2lln",
"2qpd",
"2qpe",
"3bvd",
"3eh3",
"3eh4",
"3eh5",
"3qjq",
"3qjr",
"3qjs",
"3qjt",
"3qju",
"3qjv",
"3s33",
"3s38",
"3s39",
"3s3a",
"3s3b",
"3s3c",
"3s3d",
"3s8f",
"3s8g",
"3sbp",
"3sbq"... | 79 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
432,
7950,
4,
1217
] | 4 | [] | [] | 0 | true | Family | NosZ/Cytochrome c oxidase subunit 2 | NosZ/Cytochrome c oxidase subunit 2 | NosZ/Cyto_c_oxidase_sub2 | 3 |
IPR051404 | 51,404 | Type II Toxin-Antitoxin System Antitoxin | TA_system_antitoxin | Family | 10,079 | true | false | This family of proteins includes antitoxin components of type II toxin-antitoxin (TA) systems. They function as mRNA interferase antitoxins, preventing the cessation of cell growth and inhibition of cell proliferation caused by their cognate toxins. Members of this family are involved in the regulation of cellular proc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34504"
] | [
"TA_system_antitoxin"
] | [
10079
] | 1 | [] | [] | [] | 0 | [
"2yzt",
"6g1c",
"6g1n",
"6g26",
"6hpb",
"6hpc",
"6u0i"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Opisthokonta",
"metagenomes"
] | [
742,
9043,
25,
19,
250
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type II Toxin-Antitoxin System Antitoxin | Type II Toxin-Antitoxin System Antitoxin | TA_system_antitoxin | 2 |
IPR051405 | 51,405 | phD/YefM antitoxin | phD/YefM_antitoxin | Family | 12,508 | true | false | The phD/YefM antitoxin family comprises proteins that function as antitoxin components within type II toxin-antitoxin (TA) systems. Members of the family are involved in neutralizing the effects of various toxins, such as mRNA interferases, by binding to their respective promoters to repress transcription or by directl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33713"
] | [
"phD/YefM_antitoxin"
] | [
12508
] | 1 | [] | [] | [] | 0 | [
"2a6q",
"3cto",
"3d55",
"3g5o",
"3oei",
"6l8e",
"6l8f",
"7bwf",
"7v5y",
"7v5z",
"7v6w",
"8yxv"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanimicrococcus stummii",
"Plasmid NR79",
"unclassified sequences"
] | [
12209,
28,
10,
1,
1,
259
] | 6 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | phD/YefM antitoxin | phD/YefM antitoxin | phD/YefM_antitoxin | 7 |
IPR051407 | 51,407 | Bacterial outer membrane lipoprotein and surface antigen | Bact_OM_lipoprot/Surf_antigen | Family | 11,622 | true | false | This family of proteins includes outer membrane lipoproteins and surface antigens. The lipoproteins, such as SlyB and Pcp, are involved in various bacterial outer membrane processes, including potentially facilitating the uptake of nutrients like iron complexes. The surface antigens, identified in Rickettsia species, a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35603"
] | [
"Bact_OM_lipoprot/Surf_antigen"
] | [
11622
] | 1 | [] | [] | [] | 0 | [
"7ojf",
"7ojg"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11449,
102,
71
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Bacterial outer membrane lipoprotein and surface antigen | Bacterial outer membrane lipoprotein and surface antigen | Bact_OM_lipoprot/Surf_antigen | 7 |
IPR051408 | 51,408 | Binding-protein-dependent phosphate transport system permease | Phosphate_transprt_permease | Family | 11,582 | true | false | The phosphate transport system permease family is involved in the binding-protein-dependent transport system specific for phosphate. Members of this family are likely responsible for the translocation of phosphate across the cellular membrane. They are part of a larger complex that facilitates the uptake of phosphate, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42922"
] | [
"Phosphate_transprt_permease"
] | [
11582
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
191,
11089,
11,
291
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Binding-protein-dependent phosphate transport system permease | Binding-protein-dependent phosphate transport system permease | Phosphate_transprt_permease | 9 |
IPR051409 | 51,409 | Atypical kinase ADCK | Atypical_kinase_ADCK | Family | 13,730 | true | false | The ADCK protein kinase family is involved in the biosynthesis of coenzyme Q (ubiquinone), a vital lipid-soluble electron transporter for aerobic cellular respiration. Members of the family are atypical kinases with unclear substrate specificity, lacking traditional protein kinase activity. They are hypothesized to fun... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43851"
] | [
"Atypical_kinase_ADCK"
] | [
13730
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2142789",
"R-CEL-2142789",
"R-DDI-2142789",
"R-DRE-2142789",
"R-HSA-2142789",
"R-MMU-2142789",
"R-RNO-2142789",
"R-SCE-2142789",
"R-SPO-2142789"
] | [
"REACTOME:R-BTA-2142789",
"REACTOME:R-CEL-2142789",
"REACTOME:R-DDI-2142789",
"REACTOME:R-DRE-2142789",
"REACTOME:R-HSA-2142789",
"REACTOME:R-MMU-2142789",
"REACTOME:R-RNO-2142789",
"REACTOME:R-SCE-2142789",
"REACTOME:R-SPO-2142789"
] | 9 | [
"4ped",
"5i35",
"5yjz",
"5yk0",
"5yk1",
"5yk2",
"7cy2",
"7cyr",
"7cz2",
"7udp",
"7udq"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7100,
6514,
116
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
8,
1,
23,
7,
1,
3,
6,
1,
1,
6
] | 12 | true | Family | Atypical kinase ADCK | Atypical kinase ADCK | Atypical_kinase_ADCK | 9 |
IPR051410 | 51,410 | Ferric/Cupric Reductase Transmembrane Component | Ferric/Cupric_Reductase | Family | 16,695 | true | false | The ferric reductase (FRE) family comprises enzymes that function as metalloreductases, facilitating the reduction of extracellular Fe(3+) to Fe(2+) and Cu(2+) to Cu(+). Members of the FRE family are involved in the reductive uptake of iron and copper from various sources, including Fe(3+)-salts and Fe(3+) bound to cat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32361"
] | [
"Ferric/Cupric_Reductase"
] | [
16695
] | 1 | [
"EC"
] | [
"1.16.1.9"
] | [
"EC:1.16.1.9"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
16692
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
8,
7,
2
] | 3 | true | Family | Ferric/Cupric Reductase Transmembrane Component | Ferric/Cupric Reductase Transmembrane Component | Ferric/Cupric_Reductase | 1 |
IPR051411 | 51,411 | Polyketide transferase af380-like | Polyketide_trans_af380-like | Family | 10,866 | true | true | The polyketide transferase af380 family is involved in the biosynthesis of various secondary metabolites with diverse biological activities. Members of this family function as transferases, typically catalyzing the transfer of polyketide chains onto different molecular scaffolds, which are often part of larger biosynth... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47751"
] | [
"Polyketide_trans_af380"
] | [
10866
] | 1 | [] | [] | [] | 0 | [
"2hdw",
"5xb6",
"6lzh",
"7d78",
"7d79"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudovirales sp. ctcT39",
"Eukaryota",
"unclassified sequences"
] | [
69,
7946,
1,
2810,
40
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Polyketide transferase af380-like | Polyketide transferase af380-like | Polyketide_trans_af380-like | 3 |
IPR051412 | 51,412 | Formin Homology Diaphanous subfamily | Formin_Homology_Diaphanous_sf | Family | 12,074 | true | false | The Formin Homology family, specifically the Diaphanous subfamily, encompasses proteins that play a crucial role in the regulation of the actin and microtubule cytoskeletons. Members of this family are involved in actin nucleation and elongation, contributing to the assembly of F-actin structures like actin cables and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45691"
] | [
"Formin_Homology_Diaphanous_sf"
] | [
12074
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-5663220",
"R-DME-6785631",
"R-DME-6798695",
"R-DME-8980692",
"R-DME-9013026",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013405",
"R-DME-9013406",
"R-DME-9013408",
"R-DME-9013423",
"R-DME-9035034",
"R-HSA-5663220",
"R-HSA-6785631",
"R-HSA-6798695",
"R-HSA-8980692",
"R-HSA-90130... | [
"REACTOME:R-DME-5663220",
"REACTOME:R-DME-6785631",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013404",
"REACTOME:R-DME-9013405",
"REACTOME:R-DME-9013406",
"REACTOME:R-DME-9013408",
"REACTOME:R-DME-9013423",
"REACTOM... | 52 | [
"1v9d",
"1z2c",
"2bap",
"2bnx",
"2f31",
"3eg5",
"3o4x",
"3obv",
"4uwx",
"8fg1",
"8ru2",
"9b27",
"9b3d"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group I thaumarchaeote",
"Viruses",
"metagenomes"
] | [
347,
11657,
2,
50,
18
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
54,
15,
21,
22,
3,
17,
1
] | 8 | true | Family | Formin Homology Diaphanous subfamily | Formin Homology Diaphanous subfamily | Formin_Homology_Diaphanous_sf | 5 |
IPR051413 | 51,413 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | K/Na_HCN_channel | Family | 11,121 | true | false | The HCN channel family comprises hyperpolarization-activated ion channels that are weakly selective for potassium over sodium ions. These channels are integral for generating pacemaker currents in the heart and neurons, influencing the rhythm of the heartbeat and neuronal excitability. They are also implicated in senso... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45689"
] | [
"K/Na_HCN_channel"
] | [
11121
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296061",
"R-MMU-1296061",
"R-RNO-1296061"
] | [
"REACTOME:R-HSA-1296061",
"REACTOME:R-MMU-1296061",
"REACTOME:R-RNO-1296061"
] | 3 | [
"1q3e",
"1q43",
"1q5o",
"2mng",
"2mpf",
"2ptm",
"2q0a",
"3bpz",
"3etq",
"3ffq",
"3otf",
"3u0z",
"3u10",
"3u11",
"4hbn",
"4kl1",
"4nvp",
"5khg",
"5khh",
"5khi",
"5khj",
"5khk",
"5u6o",
"5u6p",
"5v4s",
"6gyn",
"6gyo",
"6uqf",
"6uqg",
"7nmn",
"7np3",
"7np4"... | 45 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
100,
11016,
5
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
15,
10,
7,
13
] | 5 | true | Family | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | K/Na_HCN_channel | 7 |
IPR051415 | 51,415 | Lysosomal/Vacuolar Amino Acid Transporter 1 | LAAT-1 | Family | 12,038 | true | false | The LAAT-1 family comprises lysosomal and vacuolar amino acid transporters that are specialized in the pH-dependent export of cationic amino acids such as arginine, histidine, and lysine. These transporters play a crucial role in maintaining amino acid homeostasis within the cell by mediating the efflux of these amino ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16201"
] | [
"LAAT-1"
] | [
12038
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5223345",
"R-GGA-5223345",
"R-HSA-5223345",
"R-MMU-5223345",
"R-RNO-5223345",
"R-SCE-5223345",
"R-SPO-5223345"
] | [
"REACTOME:R-CEL-5223345",
"REACTOME:R-GGA-5223345",
"REACTOME:R-HSA-5223345",
"REACTOME:R-MMU-5223345",
"REACTOME:R-RNO-5223345",
"REACTOME:R-SCE-5223345",
"REACTOME:R-SPO-5223345"
] | 7 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"unclassified Klosneuvirinae"
] | [
15,
12016,
4,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
26,
2,
8,
9,
9,
4,
3,
10,
4,
3,
22
] | 11 | true | Family | Lysosomal/Vacuolar Amino Acid Transporter 1 | Lysosomal/Vacuolar Amino Acid Transporter 1 | LAAT-1 | 7 |
IPR051417 | 51,417 | Serine-Aspartate Repeat-Containing | SDr/BOS_complex | Family | 6,260 | true | false | The Serine-Aspartate Repeat-Containing Protein (SDr) family includes cell surface-associated calcium-binding proteins that play a crucial role in bacterial adhesion and pathogenesis. Members of the SDr family mediate interactions with extracellular matrix components, such as host NRXN1, to promote bacterial adhesion. S... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23303"
] | [
"SDr/BOS_complex"
] | [
6260
] | 1 | [] | [] | [] | 0 | [
"3irp",
"3irz",
"3is0",
"3is1",
"4jdz",
"9c7u",
"9c7v"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
43,
2581,
3588,
48
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
1,
5,
19,
1,
3,
3,
14
] | 9 | true | Family | Serine-Aspartate Repeat-Containing | Serine-Aspartate Repeat-Containing | SDr/BOS_complex | 2 |
IPR051418 | 51,418 | Spondin/Thrombospondin type-1 domain-containing | Spondin/Thrombospondin_T1 | Family | 9,495 | true | false | The Spondin/Thrombospondin type-1 domain-containing family is involved in cell adhesion, axon guidance, and the innate immune response. Members of the family promote attachment and neurite outgrowth in spinal cord and sensory neurons, contributing to axonal growth and guidance in the central and peripheral nervous syst... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11311"
] | [
"Spondin/Thrombospondin_T1"
] | [
9495
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5173214",
"R-DRE-5173214",
"R-HSA-5083635",
"R-HSA-5173214",
"R-MMU-5173214",
"R-RNO-5173214"
] | [
"REACTOME:R-BTA-5173214",
"REACTOME:R-DRE-5173214",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-MMU-5173214",
"REACTOME:R-RNO-5173214"
] | 6 | [
"1szl",
"1vex",
"2zot",
"2zou",
"3coo",
"3d34",
"3q13",
"8oxr"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Terrestrivirus sp.",
"metagenomes"
] | [
160,
9328,
1,
6
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
26,
9,
10,
14,
14
] | 6 | true | Family | Spondin/Thrombospondin type-1 domain-containing | Spondin/Thrombospondin type-1 domain-containing | Spondin/Thrombospondin_T1 | 9 |
IPR051419 | 51,419 | Lysine/N-terminal Methyltransferase Superfamily | Lys/N-term_MeTrsfase_sf | Family | 10,964 | true | false | The protein family includes methyltransferases that are part of the methyltransferase superfamily. Members are involved in post-translational modifications, specifically lysine and N-terminal methylation of various substrates, including citrate synthase and elongation factor 1-alpha (EEF1A1 and EEF1A2), playing roles i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12176"
] | [
"Lys/N-term_MeTrsfase_sf"
] | [
10964
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 148 | [
"2pxx"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanoregulaceae",
"ecological metagenomes"
] | [
75,
10884,
2,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
38,
2,
7,
2,
7,
6,
2,
24,
3,
34
] | 10 | true | Family | Lysine/N-terminal Methyltransferase Superfamily | Lysine/N-terminal Methyltransferase Superfamily | Lys/N-term_MeTrsfase_sf | 6 |
IPR051420 | 51,420 | Ser/Thr Protein Kinases with Diverse Regulatory Roles | Ser_Thr_Kinases_DiverseReg | Family | 9,769 | true | false | The protein family includes serine/threonine-protein kinases with diverse functions in plants and animals. In plants, members are involved in hormone perception, such as brassinosteroids and phytosulfokines, regulating development and defense responses. Some act as receptors for peptide hormones, maintaining root stem ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48005"
] | [
"Ser_Thr_Kinases_DiverseReg"
] | [
9769
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-DDI-5675482",
"R-HSA-8857538",
"R-MMU-8857538"
] | [
"EC:2.7.11.1",
"REACTOME:R-DDI-5675482",
"REACTOME:R-HSA-8857538",
"REACTOME:R-MMU-8857538"
] | 4 | [
"6xr4",
"7lht",
"7lhw",
"7li3",
"7li4",
"8fo2",
"8fo8",
"8fo9",
"8tyq",
"8tzb",
"8tze",
"8tzf",
"8tzh",
"8u7l",
"8u8a",
"8u8b",
"8vh4",
"8vh5",
"9cho",
"9ci3"
] | 20 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
14,
9753,
2
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
26,
10,
3,
1,
38,
2,
45
] | 7 | true | Family | Ser/Thr Protein Kinases with Diverse Regulatory Roles | Ser/Thr Protein Kinases with Diverse Regulatory Roles | Ser_Thr_Kinases_DiverseReg | 9 |
IPR051421 | 51,421 | RNA Processing and DNA Damage Response Regulator | RNA_Proc_DNA_Dmg_Regulator | Family | 8,798 | true | false | This family of proteins is involved in various aspects of RNA processing and DNA damage response. Members play a role in pre-mRNA splicing, particularly in the excision of introns with certain features, such as weak 3'-splice sites and high GC content. They are implicated in ribosome biogenesis through the cleavage of ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12786"
] | [
"RNA_Proc_DNA_Dmg_Regulator"
] | [
8798
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 4 | [
"5nrl",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ff7",
"6g90",
"6qdv",
"6qx9",
"6y50",
"6y53",
"6y5q",
"7abg",
"7abh",
"7abi",
"7dco",
"7evo",
"7n99",
"7onb",
"7oqb",
"7oqe",
"7q3l",
"7q4o",
"7q4p",
"7qtt",
"7vpx",
"8c6j",
"8ch6",
"8h6e"... | 54 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8798
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
2,
3,
2,
7,
3,
2,
7,
9,
1,
2,
16
] | 12 | true | Family | RNA Processing and DNA Damage Response Regulator | RNA Processing and DNA Damage Response Regulator | RNA_Proc_DNA_Dmg_Regulator | 8 |
IPR051422 | 51,422 | AlkB Family tRNA Methyltransferase/Dioxygenase | AlkB_tRNA_MeTrf/Diox | Family | 7,012 | true | false | The AlkB family proteins are involved in the post-transcriptional modification of tRNA, specifically at the wobble position of the anticodon loop. They catalyze the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine, with a preference for tRNA(Arg) and tRNA(Glu), and are also capable of hydroxylati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13069"
] | [
"AlkB_tRNA_MeTrf/Diox"
] | [
7012
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"2.1.1.229",
"PWY-6829",
"PWY-7888",
"R-HSA-6782315"
] | [
"EC:2.1.1.229",
"METACYC:PWY-6829",
"METACYC:PWY-7888",
"REACTOME:R-HSA-6782315"
] | 4 | [
"5cm2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
379,
201,
6363,
14,
55
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
2,
6,
3,
7,
6,
1,
3,
9,
1,
1,
3
] | 12 | true | Family | AlkB Family tRNA Methyltransferase/Dioxygenase | AlkB Family tRNA Methyltransferase/Dioxygenase | AlkB_tRNA_MeTrf/Diox | 9 |
IPR051423 | 51,423 | CD225/Dispanin domain-containing protein | CD225/Dispanin | Family | 6,930 | true | false | This family of proteins is involved in various cellular processes including the regulation of glucose uptake and transport, synaptic transmission, and neurotransmitter release. Members of this family modulate the recycling of glucose transporters in response to insulin, are implicated in maintaining pools of neurotrans... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14948"
] | [
"CD225/Dispanin"
] | [
6930
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1887,
5020,
23
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
9,
10,
16
] | 4 | true | Family | CD225/Dispanin domain-containing protein | CD225/Dispanin domain-containing protein | CD225/Dispanin | 4 |
IPR051424 | 51,424 | Transketolase-like | Transketolase-like | Family | 5,565 | true | false | This family of proteins is involved in the pentose phosphate pathway, a metabolic pathway parallel to glycolysis. They catalyze the transfer of two-carbon units by transferring a ketol group from a ketose donor to an aldose acceptor, forming a covalent intermediate with the cofactor thiamine pyrophosphate. This reactio... | [] | [] | [] | 0 | [
"NCBIFAM",
"PANTHER"
] | [
"NF004559",
"PTHR43195"
] | [
"PRK05899.2-5",
"Transketolase-like"
] | [
4727,
5525
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.2.1.1",
"PWY-1861",
"PWY-5723",
"PWY-6901",
"PWY-8178",
"R-HSA-163754",
"R-HSA-71336",
"R-HSA-9818028",
"R-MMU-163754",
"R-MMU-71336",
"R-RNO-163754",
"R-RNO-71336"
] | [
"EC:2.2.1.1",
"METACYC:PWY-1861",
"METACYC:PWY-5723",
"METACYC:PWY-6901",
"METACYC:PWY-8178",
"REACTOME:R-HSA-163754",
"REACTOME:R-HSA-71336",
"REACTOME:R-HSA-9818028",
"REACTOME:R-MMU-163754",
"REACTOME:R-MMU-71336",
"REACTOME:R-RNO-163754",
"REACTOME:R-RNO-71336"
] | 12 | [
"3mos",
"3ooy",
"4kxu",
"4kxv",
"4kxw",
"4kxx",
"4kxy",
"6ha3",
"6had",
"6rjb",
"8wa8",
"8wa9",
"8waa"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
57,
1467,
4001,
40
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
5,
28,
8,
14
] | 6 | true | Family | Transketolase-like | Transketolase-like | Transketolase-like | 4 |
IPR051425 | 51,425 | Formin Homology | Formin_Homology | Family | 11,672 | true | false | The Formin Homology protein family is involved in the regulation of the actin cytoskeleton, playing a crucial role in actin nucleation and the formation of linear actin filaments. Members of this family interact with Rho GTPases and are important for processes such as cell migration, filopodia formation, and the establ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45725"
] | [
"Formin_Homology"
] | [
11672
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-2559580",
"R-DME-3108214",
"R-DME-3899300",
"R-DME-4570464",
"R-DME-8939243",
"R-DME-8943724",
"R-DME-8953750",
"R-HSA-4086400",
"R-HSA-5663220",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-HSA-9013148",
"R-MMU-4086400",
"R-MMU-5663220",
"R-MMU-8980692",
"R-MMU-90130... | [
"REACTOME:R-DME-2559580",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3899300",
"REACTOME:R-DME-4570464",
"REACTOME:R-DME-8939243",
"REACTOME:R-DME-8943724",
"REACTOME:R-DME-8953750",
"REACTOME:R-HSA-4086400",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOM... | 18 | [
"2j1d",
"2z6e"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
737,
10818,
109,
8
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
26,
9,
14,
4,
1,
15
] | 7 | true | Family | Formin Homology | Formin Homology | Formin_Homology | 7 |
IPR051427 | 51,427 | Nectin and Nectin-like | Nectin/Nectin-like | Family | 6,816 | true | false | The Nectin family is involved in various cell-cell adhesion processes. Members of this family mediate adhesion through homophilic and heterophilic interactions, which can include specific interactions between different nectins. These interactions are crucial for the formation of cell-cell junctions, including adherens ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23277"
] | [
"Nectin/Nectin-like"
] | [
6816
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-418990",
"R-DME-420597",
"R-DRE-198933",
"R-DRE-418990",
"R-DRE-420597",
"R-HSA-418990",
"R-HSA-420597",
"R-MMU-418990",
"R-MMU-420597"
] | [
"REACTOME:R-DME-418990",
"REACTOME:R-DME-420597",
"REACTOME:R-DRE-198933",
"REACTOME:R-DRE-418990",
"REACTOME:R-DRE-420597",
"REACTOME:R-HSA-418990",
"REACTOME:R-HSA-420597",
"REACTOME:R-MMU-418990",
"REACTOME:R-MMU-420597"
] | 9 | [
"2l7j",
"3alp",
"3sku",
"3u82",
"3u83",
"4fmf",
"4fom",
"4frw",
"4gjt",
"4jjh",
"4myw",
"5b21",
"5b22",
"5x5w",
"6lsa"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Microbacterium invictum"
] | [
6815,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
60,
6,
12,
6,
15
] | 6 | true | Family | Nectin and Nectin-like | Nectin and Nectin-like | Nectin/Nectin-like | 7 |
IPR051429 | 51,429 | Encapsulin nanocompartment | Encapsulin_nc | Family | 3,018 | true | false | The encapsulin family is characterized by its ability to form proteinaceous nanocompartments, typically ranging from 21 to 33 nm in diameter, with walls about 2-2.5 nm thick. These nanocompartments serve as specialized storage vessels, often for iron, and may protect against oxidative damage. Encapsulins assemble into ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37165"
] | [
"Encapsulin_nc"
] | [
3018
] | 1 | [] | [] | [] | 0 | [
"2e0z",
"3dkt",
"4pt2",
"5n5e",
"6i9g",
"6nj8",
"6wkv",
"7bcv",
"7boj",
"7k5w",
"7kq5",
"7lii",
"7lij",
"7lik",
"7lil",
"7lim",
"7lis",
"7lit",
"7mh2",
"7mu1",
"7odw",
"7oe2",
"7oeu",
"7p1t",
"7phm",
"7s20",
"7s21",
"7s2t",
"7s4q",
"7s8t",
"8dn9",
"8dna"... | 57 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
329,
2649,
40
] | 3 | [] | [] | 0 | true | Family | Encapsulin nanocompartment | Encapsulin nanocompartment | Encapsulin_nc | 9 |
IPR051431 | 51,431 | Transcription initiation factor TFIID subunit 9/TAF9 | TFIID_subunit_9/TAF9 | Family | 5,333 | true | true | The TAF9 family is involved in the initiation of RNA polymerase II-dependent transcription. Members of the family function as components of the TFIID complex, which is essential for promoter recognition and pre-initiation complex formation, regardless of the presence of a TATA box. The TAF9 family includes subunits tha... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48068"
] | [
"TFIID_subunit_9"
] | [
5333
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-674695",
"R-BTA-6804756",
"R-BTA-6807505",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",
"R-BTA-76042",
"R-CEL-674695",
"R-CEL-6807505",
"R-CEL-73776",
"R-CEL-73779",
"R-CEL-75953",
"R-CEL-76042",
"R-DME-5689880",
"R-DME-674695",
"R-DME-6804756",
"R-DME-6807505",
"R-DME-73776... | [
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6804756",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-73776",
"REACTOME:R-BTA-73779",
"REACTOME:R-BTA-75953",
"REACTOME:R-BTA-76042",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6807505",
"REACTOME:R-CEL-73776",
"REACTOME:R-CEL-73779",
"REACTOME:R-CEL-75953"... | 63 | [
"1taf",
"6f3t",
"6hqa",
"6mzc",
"6mzd",
"6mzl",
"6mzm",
"6t9i",
"6t9k",
"6tb4",
"6tbm",
"7edx",
"7eg7",
"7eg8",
"7eg9",
"7ega",
"7egb",
"7egc",
"7egd",
"7ege",
"7egf",
"7egg",
"7egi",
"7egj",
"7ena",
"7enc",
"7ktr",
"7kts",
"8gxq",
"8gxs",
"8h7g",
"8wak"... | 39 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5333
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
2,
1,
1,
2,
8,
7,
1,
6,
10,
1,
1,
9
] | 12 | true | Family | Transcription initiation factor TFIID subunit 9/TAF9 | Transcription initiation factor TFIID subunit 9/TAF9 | TFIID_subunit_9/TAF9 | 7 |
IPR051432 | 51,432 | Voltage and calcium-activated potassium channel auxiliary protein | KCNMA1_auxiliary | Family | 4,010 | true | false | This family of proteins includes auxiliary components of large-conductance, voltage and calcium-activated potassium channels (BK alpha). They are involved in modulating the gating properties of these channels, including shifts in voltage dependence of activation and conversion of channel types in various cellular conte... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46473"
] | [
"KCNMA1_auxiliary"
] | [
4010
] | 1 | [
"REACTOME"
] | [
"R-HSA-9662360"
] | [
"REACTOME:R-HSA-9662360"
] | 1 | [
"8s3e"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaentomopoxvirus acuprea",
"Bacteria",
"Eukaryota"
] | [
1,
68,
3941
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
5,
8,
6,
7
] | 6 | true | Family | Voltage and calcium-activated potassium channel auxiliary protein | Voltage and calcium-activated potassium channel auxiliary protein | KCNMA1_auxiliary | 9 |
IPR051433 | 51,433 | Calcium and Integrin-Binding | CIBP | Family | 4,833 | true | false | The Calcium and integrin-binding protein family is involved in a wide range of cellular processes including cell differentiation, proliferation, migration, thrombosis, angiogenesis, cardiac hypertrophy, and apoptosis. Members of this family play key roles in bone marrow megakaryocyte differentiation, integrin signaling... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45791"
] | [
"CIBP"
] | [
4833
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9662360",
"R-HSA-9662361"
] | [
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361"
] | 2 | [
"1dgu",
"1dgv",
"1xo5",
"1y1a",
"2l4h",
"2l4i",
"2lm5",
"6ocx",
"6od0",
"6wu5",
"6wu7",
"6wud",
"7usw",
"7usx",
"7usy",
"8tkp",
"8xoq",
"8z3f"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4833
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
12,
10,
16
] | 6 | true | Family | Calcium and Integrin-Binding | Calcium and Integrin-Binding | CIBP | 4 |
IPR051434 | 51,434 | DnaJ homolog subfamily C member 5 | DnaJ_C_subfamily_member5 | Family | 4,652 | true | false | The DnaJ homolog subfamily C member 5 family comprises chaperones involved in regulated exocytosis and presynaptic functions. They act as co-chaperones for the SNARE protein SNAP-25 and play a role in the calcium-mediated control of late-stage exocytosis. These proteins are implicated in calcium-dependent neurotransmit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44027"
] | [
"DnaJ_C_subfamily_member5"
] | [
4652
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-888590",
"R-DME-6798695",
"R-DME-888590",
"R-HSA-6798695",
"R-HSA-888590",
"R-HSA-9662360",
"R-MMU-6798695",
"R-MMU-888590",
"R-RNO-6798695",
"R-RNO-888590"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-888590",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-888590",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-888590",
"REACTOME:R-HSA-9662360",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-888590",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-888590"
] | 11 | [
"2ctw",
"2n04",
"2n05"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
18,
4631,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
8,
5,
8,
7,
8
] | 6 | true | Family | DnaJ homolog subfamily C member 5 | DnaJ homolog subfamily C member 5 | DnaJ_C_subfamily_member5 | 1 |
IPR051435 | 51,435 | RING finger E3 ubiquitin-protein ligases | RING_finger_E3_ubiq-ligases | Family | 4,638 | true | false | The RING finger protein family comprises E3 ubiquitin-protein ligases involved in various cellular processes, including apoptotic signaling pathways activated by endoplasmic reticulum stress, the unfolded protein response, autophagy, and nutrient sensing. Members of the family ubiquitinate specific substrates, regulati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22791"
] | [
"RING_finger_E3_ubiq-ligases"
] | [
4638
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4637,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
10,
7,
10,
13
] | 5 | true | Family | RING finger E3 ubiquitin-protein ligases | RING finger E3 ubiquitin-protein ligases | RING_finger_E3_ubiq-ligases | 9 |
IPR051436 | 51,436 | Autophagy-related EPG5 | Autophagy-related_EPG5 | Family | 4,337 | true | false | This family of proteins is involved in the cellular process of autophagy, which is the degradation and recycling of cellular components. Members of this family play a role in various stages of autophagy, including the maturation of autophagosomes into autolysosomes, the clearance of autophagosomal cargo, and the degrad... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31139"
] | [
"Autophagy-related_EPG5"
] | [
4337
] | 1 | [
"REACTOME"
] | [
"R-DME-390150"
] | [
"REACTOME:R-DME-390150"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4337
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
16,
7,
8
] | 6 | true | Family | Autophagy-related EPG5 | Autophagy-related EPG5 | Autophagy-related_EPG5 | 6 |
IPR051437 | 51,437 | Tubulin tyrosine ligase-like monoglycylase | TTLL_monoglycylase | Family | 3,788 | true | false | This family of proteins is involved in the post-translational modification of tubulin, specifically through the addition of glycine side chains to the gamma-carboxyl groups of glutamate residues within the C-terminal tail of tubulin. Members of this family act as monoglycylases, initiating the addition of single glycin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45870"
] | [
"TTLL_monoglycylase"
] | [
3788
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.3.2.-",
"PWY-6289",
"PWY-6374",
"PWY-6378",
"PWY-6379",
"PWY-6409",
"PWY-6574",
"PWY-7510",
"PWY-7533",
"PWY-7542",
"PWY-7543",
"PWY-7549",
"PWY-7555",
"PWY-7556",
"PWY-7561",
"PWY-7563",
"PWY-7565",
"PWY-7569",
"PWY-7570",
"PWY-7571",
"PWY-7577",
"PWY-7600",
"PWY-7605... | [
"EC:6.3.2.-",
"METACYC:PWY-6289",
"METACYC:PWY-6374",
"METACYC:PWY-6378",
"METACYC:PWY-6379",
"METACYC:PWY-6409",
"METACYC:PWY-6574",
"METACYC:PWY-7510",
"METACYC:PWY-7533",
"METACYC:PWY-7542",
"METACYC:PWY-7543",
"METACYC:PWY-7549",
"METACYC:PWY-7555",
"METACYC:PWY-7556",
"METACYC:PWY-7... | 44 | [
"5vlq"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3788
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
30,
8,
11
] | 5 | true | Family | Tubulin tyrosine ligase-like monoglycylase | Tubulin tyrosine ligase-like monoglycylase | TTLL_monoglycylase | 4 |
IPR051438 | 51,438 | RNF E3 ubiquitin-protein ligase | RNF_E3_ubiq-protein_ligase | Family | 3,272 | true | false | The RNF E3 ubiquitin-protein ligase family mediates ubiquitination and proteasomal degradation of various target proteins, regulating multiple biological processes such as cell cycle, apoptosis, osteoclastogenesis, innate and adaptive immunity, and interferon production. Family members act as negative regulators of NF-... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46016"
] | [
"RNF_E3_ubiq-protein_ligase"
] | [
3272
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-983168",
"R-HSA-936440",
"R-HSA-983168",
"R-MMU-983168",
"R-RNO-983168",
"R-SSC-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-936440",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-983168",
"REACTOME:R-SSC-983168"
] | 8 | [
"5dka",
"8gbq",
"8gcb"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae",
"metagenomes"
] | [
3266,
4,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
11,
7,
12
] | 4 | true | Family | RNF E3 ubiquitin-protein ligase | RNF E3 ubiquitin-protein ligase | RNF_E3_ubiq-protein_ligase | 3 |
IPR051439 | 51,439 | Xylanolytic/arabinanolytic transcriptional activator XlnR/araR | XlnR/araR | Family | 2,517 | true | true | The xlnR/xlr1 family consists of transcriptional activators involved in the regulation of genes associated with the pentose catabolic pathway (PCP). Members of this family are primarily responsible for the induction of extracellular cellulolytic and xylanolytic enzymes, as well as the intracellular activities of D-xylo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47663"
] | [
"XlnR/Xlr1"
] | [
2517
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2517
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Xylanolytic/arabinanolytic transcriptional activator XlnR/araR | Xylanolytic/arabinanolytic transcriptional activator XlnR/araR | XlnR/araR | 5 |
IPR051440 | 51,440 | Goosecoid-like homeobox | Goosecoid-like_HB | Family | 1,776 | true | false | This family of proteins includes transcription factors characterized by a homeobox domain, which is a DNA-binding motif. They are involved in early embryonic development and organogenesis. Members of this family play crucial roles in regulating the expression of genes that are essential for the development of various s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46643"
] | [
"Goosecoid-like_HB"
] | [
1776
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9754189",
"R-HSA-9823730"
] | [
"REACTOME:R-HSA-9754189",
"REACTOME:R-HSA-9823730"
] | 2 | [
"2dmu"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1776
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
4,
2,
4,
6
] | 6 | true | Family | Goosecoid-like homeobox | Goosecoid-like homeobox | Goosecoid-like_HB | 2 |
IPR051441 | 51,441 | Selenoprotein W and related | SelW_related | Family | 1,917 | true | false | This family of proteins includes members that are involved in cellular antioxidant activities, particularly as glutathione (GSH)-dependent antioxidants. They may participate in redox-related processes and could play roles in conditions related to selenium deficiency, such as myopathies. Some family members are implicat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15124"
] | [
"SelW_related"
] | [
1917
] | 1 | [] | [] | [] | 0 | [
"2ljk",
"2npb"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Thermoproteus tenax virus 1 (strain VT3)",
"metagenomes"
] | [
21,
449,
1426,
1,
20
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
4,
2,
4,
4,
1,
10
] | 6 | true | Family | Selenoprotein W and related | Selenoprotein W and related | SelW_related | 2 |
IPR051442 | 51,442 | B3 domain-containing protein | B3_domain | Family | 1,966 | true | false | This family of proteins contains the B3 domain, which is a DNA-binding domain involved in various biological processes. Members of this family are known to function as transcription factors that regulate gene expression in response to developmental cues and environmental signals. They play pivotal roles in plant growth... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34269"
] | [
"B3_domain"
] | [
1966
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
1966
] | 1 | [
"Arabidopsis thaliana"
] | [
57
] | 1 | true | Family | B3 domain-containing protein | B3 domain-containing protein | B3_domain | 9 |
IPR051443 | 51,443 | X-linked Lymphocyte-regulated/Synaptonemal Complex Protein 3 | XLR/SYCP3 | Family | 1,400 | true | false | The XLR/SYCP3 family proteins are key components of the synaptonemal complexes (SCS), which form between homologous chromosomes during meiotic prophase. They play a crucial role in centromere pairing during meiosis in male germ cells, which is essential for normal meiosis and male fertility. These proteins also contrib... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19368"
] | [
"XLR/SYCP3"
] | [
1400
] | 1 | [
"REACTOME"
] | [
"R-HSA-1221632"
] | [
"REACTOME:R-HSA-1221632"
] | 1 | [
"4cpc",
"6dd8",
"6dd9"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1400
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
97,
28
] | 4 | true | Family | X-linked Lymphocyte-regulated/Synaptonemal Complex Protein 3 | X-linked Lymphocyte-regulated/Synaptonemal Complex Protein 3 | XLR/SYCP3 | 9 |
IPR051444 | 51,444 | Parasitic Reproductive and Invasion Surface Protein | Parasite_Repro/Invasion_Surf | Family | 671 | true | false | This family of proteins includes surface proteins primarily involved in the reproductive processes and lifecycle progression of a parasitic organism. Members of this family are essential for male gamete fertility, playing a crucial role in gamete fusion and interaction with host cells. Some proteins are necessary for t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38796"
] | [
"Parasite_Repro/Invasion_Surf"
] | [
671
] | 1 | [] | [] | [] | 0 | [
"2loe",
"2ymo",
"4ys4",
"7s7q",
"7s7r",
"9e7n",
"9e7o",
"9e7p",
"9mvt",
"9mvv",
"9n5h",
"9n5i",
"9n5k",
"9n5o"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
671
] | 1 | [] | [] | 0 | true | Family | Parasitic Reproductive and Invasion Surface Protein | Parasitic Reproductive and Invasion Surface Protein | Parasite_Repro/Invasion_Surf | 3 |
IPR051445 | 51,445 | Lymphocyte Antigen 6 Family Modulators | LY6H/LY6L_nAChR_modulators | Family | 510 | true | false | The LY6H/LY6L protein family is characterized by its role in modulating the activity of nicotinic acetylcholine receptors (nAChRs). Members of this family, such as LY6H in humans and mice, are believed to inhibit the maximum response of alpha-3:beta-4-containing nAChRs. They may also be involved in the intracellular tr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32217"
] | [
"LY6H/LY6L_nAChR_modulators"
] | [
510
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
510
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
24,
18
] | 3 | true | Family | Lymphocyte Antigen 6 Family Modulators | Lymphocyte Antigen 6 Family Modulators | LY6H/LY6L_nAChR_modulators | 2 |
IPR051446 | 51,446 | HTH-type transcriptional regulator with aminotransferase domain | HTH_trans_reg/aminotransferase | Family | 74,718 | true | false | This family of proteins includes transcriptional regulators with a helix-turn-helix (HTH) motif, which are involved in various cellular processes. Members of this family are known to regulate the expression of operons related to amino acid metabolism, such as taurine and gamma-aminobutyrate (GABA), as well as pathways ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46577"
] | [
"HTH_trans_reg/aminotransferase"
] | [
74718
] | 1 | [] | [] | [] | 0 | [
"4mgr",
"4n0b",
"4tv7",
"5t4j",
"5t4k",
"5x03",
"6uxz",
"7pq9",
"7zla",
"7zn5",
"7zpa",
"7zth",
"8vxk",
"8vxl"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halorubrum tibetense",
"unclassified sequences"
] | [
74414,
69,
1,
234
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | HTH-type transcriptional regulator with aminotransferase domain | HTH-type transcriptional regulator with aminotransferase domain | HTH_trans_reg/aminotransferase | 7 |
IPR051447 | 51,447 | Lipoprotein-releasing system transmembrane protein | Lipoprotein-release_system | Family | 32,946 | true | false | This family of proteins is involved in an ATP-dependent transport system that facilitates the release of lipoproteins from the inner membrane, targeting them to the outer membrane in bacteria. The release mechanism is contingent on a specific sorting signal, which is the absence of an aspartic acid residue at the secon... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30489"
] | [
"Lipoprotein-release_system"
] | [
32946
] | 1 | [] | [] | [] | 0 | [
"5naa",
"5udf",
"6f3z",
"6f49",
"7arh",
"7ari",
"7arj",
"7ark",
"7arl",
"7arm",
"7mdx",
"7mdy",
"7v8i",
"7v8l",
"7v8m",
"9grc",
"9gvk"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
515,
31647,
42,
3,
739
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Lipoprotein-releasing system transmembrane protein | Lipoprotein-releasing system transmembrane protein | Lipoprotein-release_system | 2 |
IPR051448 | 51,448 | CdaR-like transcriptional regulators | CdaR-like_regulators | Family | 58,215 | true | false | This family of proteins includes transcriptional activators that regulate the expression of various operons. Members of this family are involved in the response to specific environmental stimuli or intracellular signals, such as the availability of certain amino acids or the presence of specific metabolites. They can a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33744"
] | [
"CdaR-like_regulators"
] | [
58215
] | 1 | [] | [] | [] | 0 | [
"3onq",
"9f80"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
57931,
13,
271
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | CdaR-like transcriptional regulators | CdaR-like transcriptional regulators | CdaR-like_regulators | 2 |
IPR051449 | 51,449 | ABC-2 integral membrane transporter component | ABC-2_transporter_component | Family | 43,822 | true | false | This family of proteins includes integral membrane components of ABC transporter complexes, which are involved in the translocation of substrates across cellular membranes. Members of this family are implicated in various functions, such as antibiotic resistance and efflux of specific compounds like cefoperazone. Some ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30294"
] | [
"ABC-2_transporter_component"
] | [
43822
] | 1 | [] | [] | [] | 0 | [
"3cni"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
527,
42183,
478,
634
] | 4 | [
"Drosophila melanogaster",
"Escherichia coli (strain K12)"
] | [
3,
3
] | 2 | true | Family | ABC-2 integral membrane transporter component | ABC-2 integral membrane transporter component | ABC-2_transporter_component | 1 |
IPR051450 | 51,450 | Gfo/Idh/MocA Oxidoreductases | Gfo/Idh/MocA_Oxidoreductases | Family | 36,861 | true | false | This family of proteins includes enzymes that are involved in various oxidation-reduction (redox) reactions, which are critical for cellular metabolism. Members of this family are characterized by their ability to catalyze the transfer of electrons from one molecule to another, often using NADH or NADPH as cofactors. F... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43377"
] | [
"Gfo/Idh/MocA_Oxidoreductases"
] | [
36861
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-189483",
"R-HSA-9707564",
"R-MMU-189483",
"R-MMU-9707564",
"R-RNO-189483",
"R-RNO-9707564"
] | [
"REACTOME:R-HSA-189483",
"REACTOME:R-HSA-9707564",
"REACTOME:R-MMU-189483",
"REACTOME:R-MMU-9707564",
"REACTOME:R-RNO-189483",
"REACTOME:R-RNO-9707564"
] | 6 | [
"1gcu",
"1lc0",
"1lc3",
"2h63",
"3c1a",
"3db2",
"3ip3",
"4gmf",
"4gmg",
"5b3t",
"5b3u",
"5b3v",
"5kvq",
"5kvs",
"6o15",
"6z3b",
"6z3c",
"7bvj",
"7bvk",
"7wzd",
"7x1x",
"7x2y",
"8w9s",
"9azo"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1583,
29285,
5180,
6,
807
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
1,
3,
5,
1,
3
] | 6 | true | Family | Gfo/Idh/MocA Oxidoreductases | Gfo/Idh/MocA Oxidoreductases | Gfo/Idh/MocA_Oxidoreductases | 2 |
IPR051452 | 51,452 | Diverse Oxidoreductases | Diverse_Oxidoreductases | Family | 30,097 | true | false | This family of proteins includes various oxidoreductases that catalyze the oxidation of diverse substrates, ranging from small molecules like carbon monoxide and xanthine to more complex organic compounds such as nicotine and caffeine. Members of this family are involved in key enzymatic processes that facilitate the d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44379"
] | [
"Diverse_Oxidoreductases"
] | [
30097
] | 1 | [] | [] | [] | 0 | [
"1ffu",
"1ffv",
"1n5w",
"1n60",
"1n61",
"1n62",
"1n63",
"1rm6",
"1sb3",
"1t3q",
"1zxi",
"3hrd",
"4zoh",
"7dqx",
"8gy3",
"8uem"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
555,
28776,
30,
736
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Diverse Oxidoreductases | Diverse Oxidoreductases | Diverse_Oxidoreductases | 6 |
IPR051453 | 51,453 | Metallo-Beta-Lactamase Glyoxalase II | MBL_Glyoxalase_II | Family | 30,573 | true | false | The Glyoxalase II family, part of the metallo-beta-lactamase superfamily, includes proteins involved in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis. Members of the family, such as hydroxyacylglutathione hydrolases, catalyze the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46233"
] | [
"MBL_Glyoxalase_II"
] | [
30573
] | 1 | [] | [] | [] | 0 | [
"2xf4",
"2zwr",
"2zzi",
"5aeb",
"5k0w",
"6n36",
"7ev5",
"7l0b"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Inoviridae sp. ctDEu7",
"unclassified sequences"
] | [
1006,
28303,
524,
1,
739
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Metallo-Beta-Lactamase Glyoxalase II | Metallo-Beta-Lactamase Glyoxalase II | MBL_Glyoxalase_II | 7 |
IPR051455 | 51,455 | Bacterial solute-binding protein 3 | Bact_solute-bind_prot3 | Family | 33,540 | true | false | The bacterial solute-binding protein 3 family is involved in the transport of various amino acids across the cell membrane, functioning as part of different ABC transporter complexes. Members of the family bind specific amino acids with high affinity, which is critical for their transport into the cell. These proteins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30085"
] | [
"Bact_solute-bind_prot3"
] | [
33540
] | 1 | [] | [] | [] | 0 | [
"1xt8",
"2ia4",
"2v25",
"2vha",
"2yjp",
"4z9n",
"5eyf",
"6h1u",
"6h20",
"6h2t",
"8ovn",
"8ovo",
"8ovp",
"9fbu"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Cafeteria roenbergensis virus (strain BV-PW1)",
"Eukaryota",
"unclassified sequences"
] | [
24,
33096,
1,
220,
199
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Bacterial solute-binding protein 3 | Bacterial solute-binding protein 3 | Bact_solute-bind_prot3 | 7 |
IPR051457 | 51,457 | 2-oxoacid:ferredoxin oxidoreductase | 2-oxoacid:Fd_oxidoreductase | Family | 19,804 | true | false | This family of proteins includes enzymes that catalyze the coenzyme A-dependent oxidative decarboxylation of various 2-oxoacids, such as pyruvate, 2-oxobutyrate, glyoxylate, and 2-oxoglutarate, to form their corresponding CoA derivatives. These reactions are crucial in metabolic pathways, including the tricarboxylic ac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48084"
] | [
"2-oxoacid:Fd_oxidoreductase"
] | [
19804
] | 1 | [
"EC"
] | [
"1.2.7"
] | [
"EC:1.2.7"
] | 1 | [
"5b46",
"5b47",
"5b48",
"6n2n",
"6n2o",
"8ys5",
"8ys6"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1611,
17465,
28,
700
] | 4 | [] | [] | 0 | true | Family | 2-oxoacid:ferredoxin oxidoreductase | 2-oxoacid:ferredoxin oxidoreductase | 2-oxoacid:Fd_oxidoreductase | 4 |
IPR051458 | 51,458 | Cytosolic and Metallo Dipeptidase | Cyt/Met_Dipeptidase | Family | 27,784 | true | false | The peptidase M20 family is involved in the hydrolysis of dipeptides, with specific members displaying tissue-specific catabolism of threonyl dipeptides and high activity toward cysteinylglycine, an intermediate in glutathione metabolism. Some members are involved in the degradation of glutathione and other gamma-glu-X... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43270"
] | [
"Cyt/Met_Dipeptidase"
] | [
27784
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.13",
"R-BTA-174403",
"R-BTA-9753281",
"R-HSA-174403",
"R-HSA-9753281",
"R-MMU-174403",
"R-MMU-9753281",
"R-RNO-174403",
"R-RNO-9753281",
"R-SCE-174403",
"R-SCE-9753281",
"R-SPO-174403",
"R-SPO-9753281"
] | [
"EC:3.4.13",
"REACTOME:R-BTA-174403",
"REACTOME:R-BTA-9753281",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-9753281",
"REACTOME:R-MMU-174403",
"REACTOME:R-MMU-9753281",
"REACTOME:R-RNO-174403",
"REACTOME:R-RNO-9753281",
"REACTOME:R-SCE-174403",
"REACTOME:R-SCE-9753281",
"REACTOME:R-SPO-174403",
... | 13 | [
"2pok",
"2zof",
"2zog",
"3dlj",
"3pfe",
"4g1p",
"4mmo",
"4ruh"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
266,
19032,
8190,
296
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
3,
3,
24,
9,
2,
9,
2,
1
] | 9 | true | Family | Cytosolic and Metallo Dipeptidase | Cytosolic and Metallo Dipeptidase | Cyt/Met_Dipeptidase | 7 |
IPR051459 | 51,459 | Cytochrome c-type Dehydrogenase | Cytochrome_c-type_DH | Family | 25,614 | true | false | The Cytochrome c-type Dehydrogenase family comprises enzymes that are involved in various electron transfer processes. Members of this family function as integral components of multicomponent enzyme systems, catalyzing the oxidation of substrates such as ethanol, thiosulfate, and D-gluconate, and transferring electrons... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35008"
] | [
"Cytochrome_c-type_DH"
] | [
25614
] | 1 | [] | [] | [] | 0 | [
"1c52",
"1dt1",
"1foc",
"1qyz",
"1r0q",
"2fwl",
"2xts",
"2yqb",
"2zoo",
"3vnw",
"3zbm",
"3ziy",
"4ax3",
"4v2k",
"4wq7",
"4wq8",
"4wq9",
"4wqa",
"4wqb",
"4wqc",
"4wqd",
"4wqe",
"5obo",
"5ocb",
"5ocf",
"6f1q",
"6fja",
"6h5l",
"6qpv",
"6qpx",
"6qpz",
"6qq0"... | 55 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
25243,
34,
27,
310
] | 4 | [] | [] | 0 | true | Family | Cytochrome c-type Dehydrogenase | Cytochrome c-type Dehydrogenase | Cytochrome_c-type_DH | 9 |
IPR051462 | 51,462 | CBS domain-containing protein | CBS_domain-containing | Family | 12,118 | true | false | This family of proteins includes members with diverse biological functions, primarily characterized by the presence of a CBS domain. The CBS domain is known to play a role in various cellular processes through its involvement in the regulation of enzyme activity and protein conformation. Proteins in this family are inv... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48108"
] | [
"CBS_domain-containing"
] | [
12118
] | 1 | [] | [] | [] | 0 | [
"2p9m",
"2yzq",
"3fv6",
"3fwr",
"3fws",
"3sl7",
"4gqv",
"4gqw",
"4gqy",
"5awe",
"5iip",
"5ks7",
"7lzg"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
846,
6697,
4484,
91
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
13,
1,
10,
1,
39
] | 5 | true | Family | CBS domain-containing protein | CBS domain-containing protein | CBS_domain-containing | 7 |
IPR051463 | 51,463 | Peptidase U62 metalloprotease | Peptidase_U62_metallo | Family | 19,136 | true | false | This family of proteins includes metalloproteases that are characterized by a conserved motif which likely serves as their active site. Members of this family are involved in various biological processes, including the degradation of specific substrates such as azocasein and the bacterial CcdA protein. Some proteins in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30624"
] | [
"Peptidase_U62_metallo"
] | [
19136
] | 1 | [] | [] | [] | 0 | [
"5nj5",
"5nj9",
"5nja",
"5njb",
"5njc",
"5njf"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Streptomyces phage Success",
"unclassified sequences"
] | [
846,
17678,
51,
1,
560
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Peptidase U62 metalloprotease | Peptidase U62 metalloprotease | Peptidase_U62_metallo | 6 |
IPR051464 | 51,464 | Peptidase M42 aminopeptidase | Peptidase_M42_aminopept | Family | 19,980 | true | false | The peptidase M42 family comprises enzymes with aminopeptidase activity, which progressively cleave amino acids from the N-terminus of peptide substrates. Members of this family exhibit broad specificity, hydrolyzing di-, tri-, and tetrapeptides with various N-terminal amino acids, although some show preference for spe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32481"
] | [
"Peptidase_M42_aminopept"
] | [
19980
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.4.11.-",
"PWY-6423",
"PWY-7694",
"PWY-7954"
] | [
"EC:3.4.11.-",
"METACYC:PWY-6423",
"METACYC:PWY-7694",
"METACYC:PWY-7954"
] | 4 | [
"1vhe",
"1vho",
"1xfo",
"1y0r",
"1y0y",
"1ylo",
"2cf4",
"2fvg",
"2gre",
"2pe3",
"2wyr",
"2wzn",
"3cpx",
"3isx",
"3kl9",
"4p6y",
"4wwv",
"4x8i",
"5ds0",
"5l6z",
"5ne6",
"5ne7",
"5ne8",
"5ne9",
"6f3k",
"6nw5",
"6r8n"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine phage"
] | [
1117,
18568,
23,
271,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Peptidase M42 aminopeptidase | Peptidase M42 aminopeptidase | Peptidase_M42_aminopept | 2 |
IPR051465 | 51,465 | Cell Envelope Structural Component | Cell_Envelope_Struct_Comp | Family | 19,867 | true | false | This family of proteins includes components that are involved in the structural organization and integrity of the cell envelope. They typically exhibit a tripartite organization with a C-terminal outer membrane beta-barrel domain, a central trimeric coiled coil, and an N-terminal domain that can interact with the pepti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43308"
] | [
"Cell_Envelope_Struct_Comp"
] | [
19867
] | 1 | [] | [] | [] | 0 | [
"3pyw",
"6bt4",
"7zgx",
"7zgy",
"8acq",
"8ae1",
"8agd",
"8bym",
"8bys",
"8byt",
"8bz2",
"9g93"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
19719,
8,
19,
121
] | 4 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Family | Cell Envelope Structural Component | Cell Envelope Structural Component | Cell_Envelope_Struct_Comp | 6 |
IPR051466 | 51,466 | D-amino acid metabolism enzyme | D-amino_acid_metab_enzyme | Family | 19,536 | true | false | This family of proteins includes enzymes that are involved in the metabolism of various D-amino acids, primarily D-serine, D-threonine, and D-hydroxyaspartate. Members of this family catalyze reactions such as the deamination of D-serine to produce pyruvate and ammonia, which may play a role in detoxification. Some enz... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28004"
] | [
"D-amino_acid_metab_enzyme"
] | [
19536
] | 1 | [] | [] | [] | 0 | [
"3anu",
"3anv",
"3awn",
"3awo",
"3gwq",
"3llx",
"3wqc",
"3wqd",
"3wqe",
"3wqf",
"3wqg",
"4pb3",
"4pb4",
"4pb5",
"4v15",
"6qkb",
"7dib",
"7yqa"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
41,
15965,
3314,
216
] | 4 | [
"Danio rerio",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1,
1
] | 4 | true | Family | D-amino acid metabolism enzyme | D-amino acid metabolism enzyme | D-amino_acid_metab_enzyme | 3 |
IPR051468 | 51,468 | Fungal Secondary Metabolite SDRs | Fungal_SecMetab_SDRs | Family | 21,120 | true | false | The Short-chain dehydrogenases/reductases (SDR) family comprises enzymes involved in various biosynthetic pathways for the production of secondary metabolites, including toxins, pigments, and pharmaceutical compounds. Members of the family function as oxidoreductases, catalyzing reactions such as reductions of ketones ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43544"
] | [
"Fungal_SecMetab_SDRs"
] | [
21120
] | 1 | [] | [] | [] | 0 | [
"1sny",
"1yo6",
"3wxb"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Mimiviridae",
"metagenomes"
] | [
7348,
13694,
8,
28,
42
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
8,
11,
13,
1,
5,
2,
4,
8
] | 8 | true | Family | Fungal Secondary Metabolite SDRs | Fungal Secondary Metabolite SDRs | Fungal_SecMetab_SDRs | 9 |
IPR051469 | 51,469 | Flagellar motor switch protein FliN/MopA/SpaO | FliN/MopA/SpaO | Family | 14,565 | true | false | The FliN/MopA/SpaO family comprises proteins that are integral components of the flagellar motor switch complex, also known as the C ring, which is essential for bacterial motility. Members of this family, including FliN, are involved in forming the complex at the base of the basal body. The switch complex is responsib... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43484"
] | [
"FliN/MopA/SpaO"
] | [
14565
] | 1 | [] | [] | [] | 0 | [
"1o6a",
"1yab",
"4hyn",
"4yxb",
"4yxc",
"5xrw",
"8umd",
"8umx",
"8uox",
"8upl",
"8vib",
"8vid",
"8vkq",
"8vkr",
"8wiw",
"8wo5",
"8woe",
"8xp0",
"8xp1",
"8yjt",
"9n49",
"9n4z"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"unclassified sequences"
] | [
14349,
13,
3,
200
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flagellar motor switch protein FliN/MopA/SpaO | Flagellar motor switch protein FliN/MopA/SpaO | FliN/MopA/SpaO | 8 |
IPR051470 | 51,470 | Thiol:disulfide interchange protein | Thiol:disulfide_interchange | Family | 13,598 | true | false | This family of proteins is involved in the formation and rearrangement of disulfide bonds in periplasmic proteins, which is crucial for their proper folding and stability. Members of this family function by transferring disulfide bonds to substrate proteins, thereby becoming reduced in the process. They are subsequentl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35272"
] | [
"Thiol:disulfide_interchange"
] | [
13598
] | 1 | [] | [] | [] | 0 | [
"1eej",
"1g0t",
"1jzd",
"1jzo",
"1t3b",
"1tjd",
"1v57",
"1v58",
"2h0g",
"2h0h",
"2h0i",
"2iy2",
"2iyj",
"3gv1",
"4i5q",
"4ilf",
"4ml1",
"4ml6",
"4mly",
"4npb",
"4xvw",
"5g1k",
"5g1l",
"5id4",
"5idr",
"6mhh",
"6nen",
"7rgv",
"8pxd",
"8pxf",
"9dcg"
] | 31 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24,
13331,
29,
214
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Thiol:disulfide interchange protein | Thiol:disulfide interchange protein | Thiol:disulfide_interchange | 6 |
IPR051471 | 51,471 | Bacterial PTS system sugar-specific components | Bacterial_PTS_sugar_comp | Family | 17,264 | true | false | The protein family is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a key carbohydrate active transport system in bacteria. Members of the family catalyze the phosphorylation of sugar substrates while translocating them across the cell membrane. Specific components of the system, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33799"
] | [
"Bacterial_PTS_sugar_comp"
] | [
17264
] | 1 | [] | [] | [] | 0 | [
"1pdo",
"1vrc",
"1vsq",
"2jzn",
"2jzo",
"3bed",
"3ipr",
"3lfh",
"3mtq",
"4tkz",
"5im4",
"5t3u",
"6fmg"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
10,
17127,
6,
121
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Bacterial PTS system sugar-specific components | Bacterial PTS system sugar-specific components | Bacterial_PTS_sugar_comp | 7 |
IPR051472 | 51,472 | Type III Secretion System Stator and Flagellar Assembly | T3SS_Stator/FliH | Family | 12,732 | true | false | The SctL stator family and FliH family proteins are involved in distinct bacterial systems with roles in motility and interaction with host cells. The SctL stator family proteins are components of the type III secretion system (T3SS), also known as the injectisome. They are responsible for injecting bacterial effector ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34982"
] | [
"T3SS_Stator/FliH"
] | [
12732
] | 1 | [] | [] | [] | 0 | [
"5b0o"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
12569,
11,
152
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type III Secretion System Stator and Flagellar Assembly | Type III Secretion System Stator and Flagellar Assembly | T3SS_Stator/FliH | 7 |
IPR051473 | 51,473 | Pyranose 2-oxidase-like | P2Ox-like | Family | 13,389 | true | true | This family includes a group of GMC oxidoreductases, including Pyranose 2-oxidase from Trametes hirsuta (White-rot fungus), a diagnostic marker of diabetes mellitus. Members of this entry catalyse the oxidation of various sugars and related compounds. Some members play crucial roles in metabolic processes such as ligni... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42784"
] | [
"GMC_Oxidoreductase"
] | [
13389
] | 1 | [
"EC"
] | [
"1.1.3"
] | [
"EC:1.1.3"
] | 1 | [
"1tt0",
"1tzl",
"2f5v",
"2f6c",
"2igk",
"2igm",
"2ign",
"2igo",
"3bg6",
"3bg7",
"3bly",
"3fdy",
"3k4b",
"3k4c",
"3k4j",
"3k4k",
"3k4l",
"3k4m",
"3k4n",
"3lsh",
"3lsi",
"3lsk",
"3lsm",
"3pl8",
"4mif",
"4mig",
"4mih",
"4moe",
"4mof",
"4mog",
"4moh",
"4moi"... | 59 | [
"PUB00155036"
] | [
"16105703"
] | [
"Expression of the pyranose 2-oxidase from Trametes pubescens in Escherichia coli and characterization of the recombinant enzyme."
] | [
2005
] | 1 | [] | [
"IPR012814"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
346,
11941,
964,
138
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Pyranose 2-oxidase-like | Pyranose 2-oxidase-like | P2Ox-like | 3 |
IPR051474 | 51,474 | Anti-sigma-K/W factor | Anti-sigma-K/W_factor | Family | 12,117 | true | false | The anti-sigma-K factor family includes proteins that regulate the activity of extracytoplasmic function (ECF) sigma factors such as SigK by maintaining them in an inactive state. These anti-sigma factors bind to their respective sigma factors and prevent them from initiating transcription. The inactivation is reversed... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37461"
] | [
"Anti-sigma-K/W_factor"
] | [
12117
] | 1 | [] | [] | [] | 0 | [
"4nqw"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halococcoides cellulosivorans",
"unclassified sequences"
] | [
12046,
8,
1,
62
] | 4 | [] | [] | 0 | true | Family | Anti-sigma-K/W factor | Anti-sigma-K/W factor | Anti-sigma-K/W_factor | 5 |
IPR051475 | 51,475 | Diverse Ion Transporter | Diverse_Ion_Transporter | Family | 10,047 | true | false | This family of proteins includes transporters involved in diverse biological processes such as biomineralization, melanogenesis, and possibly ion transport and pH regulation in various cellular compartments. Some members are implicated in the formation of magnetosomes, which are intracellular organelles in magnetotacti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43568"
] | [
"Diverse_Ion_Transporter"
] | [
10047
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5662702",
"R-MMU-5662702"
] | [
"REACTOME:R-HSA-5662702",
"REACTOME:R-MMU-5662702"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
302,
7216,
2342,
187
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
17,
1,
5,
2,
6
] | 6 | true | Family | Diverse Ion Transporter | Diverse Ion Transporter | Diverse_Ion_Transporter | 7 |
IPR051476 | 51,476 | Bacterial Response Regulator Aspartate Phosphatase | Bac_ResReg_Asp_Phosphatase | Family | 7,654 | true | false | The Rap family proteins are bacterial response regulators with diverse roles in cellular processes such as sporulation and competence development. Members of the family act as aspartate phosphatases, targeting specific response regulators like Spo0F, thereby modulating sporulation initiation. Some Rap proteins also bin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46630"
] | [
"Bac_ResReg_Asp_Phosphatase"
] | [
7654
] | 1 | [] | [] | [] | 0 | [
"3q15",
"3ulq",
"4gyo",
"4i9e",
"8glv",
"8j07",
"8rst",
"8rsu",
"8rsv",
"8rtc",
"9d2f",
"9e5c",
"9fqr"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage phi3T",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
92,
1,
5260,
2134,
167
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
8,
3,
4
] | 4 | true | Family | Bacterial Response Regulator Aspartate Phosphatase | Bacterial Response Regulator Aspartate Phosphatase | Bac_ResReg_Asp_Phosphatase | 6 |
IPR051479 | 51,479 | Pyruvate synthase subunit PorB-like | PorB-like | Family | 2,837 | true | true | This family of prokaryotic proteins includes various subunits involved in oxidative decarboxylation reactions that are essential for anaerobic metabolism, including Pyruvate synthase subunit PorB from Pyrococcus furiosus. Members of this group catalyse the conversion of different substrates such as pyruvate, ketoisoval... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42897"
] | [
"AnOxDcarbx_Subunits"
] | [
2837
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.7.1",
"PWY-5392",
"PWY-5483",
"PWY-5493",
"PWY-5497",
"PWY-5538",
"PWY-5600",
"PWY-6142",
"PWY-6583",
"PWY-6587",
"PWY-6588",
"PWY-6863",
"PWY-6876",
"PWY-8189",
"PWY-8275",
"PWY-8303",
"PWY-8377"
] | [
"EC:1.2.7.1",
"METACYC:PWY-5392",
"METACYC:PWY-5483",
"METACYC:PWY-5493",
"METACYC:PWY-5497",
"METACYC:PWY-5538",
"METACYC:PWY-5600",
"METACYC:PWY-6142",
"METACYC:PWY-6583",
"METACYC:PWY-6587",
"METACYC:PWY-6588",
"METACYC:PWY-6863",
"METACYC:PWY-6876",
"METACYC:PWY-8189",
"METACYC:PWY-8... | 17 | [
"5c4i",
"5exd",
"5exe",
"9bt4"
] | 4 | [] | [] | [] | [] | 0 | [] | [
"IPR054808"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Geodia barretti",
"metagenomes"
] | [
891,
1723,
1,
222
] | 4 | [] | [] | 0 | true | Family | Pyruvate synthase subunit PorB-like | Pyruvate synthase subunit PorB-like | PorB-like | 7 |
IPR051481 | 51,481 | BTB/POZ domain-containing protein and Galectin-3-binding | BTB-POZ/Galectin-3-binding | Family | 9,173 | true | false | This family of proteins includes members with a BTB/POZ domain and galectin-3-binding capabilities. The BTB/POZ domain is known for its role in protein-protein interactions, which can be crucial for various cellular processes. Some members of this family are involved in promoting integrin-mediated cell adhesion, which ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24410"
] | [
"BTB-POZ/Galectin-3-binding"
] | [
9173
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-114608",
"R-DRE-114608",
"R-HSA-114608",
"R-MMU-114608",
"R-RNO-114608"
] | [
"REACTOME:R-BTA-114608",
"REACTOME:R-DRE-114608",
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-RNO-114608"
] | 5 | [
"6gfb",
"6gfc"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nucleocytoviricota"
] | [
9166,
7
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
20,
10,
11,
4,
8
] | 7 | true | Family | BTB/POZ domain-containing protein and Galectin-3-binding | BTB/POZ domain-containing protein and Galectin-3-binding | BTB-POZ/Galectin-3-binding | 3 |
IPR051482 | 51,482 | Cholesterol transport domain-containing protein | Cholesterol_transport | Family | 10,835 | true | false | This family of proteins is involved in the non-vesicular transport of cholesterol between cellular membranes, particularly from the plasma membrane to the endoplasmic reticulum. Members contain unique domains that bind cholesterol and phosphatidylserine, enabling them to serve as molecular bridges facilitating choleste... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23319"
] | [
"Cholesterol_transport"
] | [
10835
] | 1 | [] | [] | [] | 0 | [
"4tyz",
"5yqi",
"5yqj",
"5yqp",
"5yqq",
"5yqr",
"5ys0",
"6byd",
"6bym",
"6cay",
"6gn5",
"6gqf",
"7azn",
"8axw"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10835
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
94,
10,
22,
15,
2,
30,
4,
1
] | 9 | true | Family | Cholesterol transport domain-containing protein | Cholesterol transport domain-containing protein | Cholesterol_transport | 2 |
IPR051483 | 51,483 | Microtubule-associated protein 7 domain-containing protein | MAP7_domain-containing | Family | 10,907 | true | false | This family of proteins is involved in the stabilization and assembly of microtubules. Members are known to associate dynamically with microtubules and may play significant roles during the polarization and differentiation of epithelial cells. They are also implicated in the formation of intercellular contacts and may ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15073"
] | [
"MAP7_domain-containing"
] | [
10907
] | 1 | [] | [] | [] | 0 | [
"7sgs"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
56,
10840,
8,
3
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
91,
12,
27,
14,
29
] | 5 | true | Family | Microtubule-associated protein 7 domain-containing protein | Microtubule-associated protein 7 domain-containing protein | MAP7_domain-containing | 8 |
IPR051484 | 51,484 | Tensin Phosphatase | Tensin_PTEN_phosphatase | Family | 10,325 | true | false | The Tensin phosphatase family is involved in various cellular processes including cell migration, proliferation, and cytoskeletal organization. Members of the family promote cell migration by interacting with integrins and the cytoplasmic tail of ITGB1, leading to the disassembly of actin stress fibers. They regulate t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45734"
] | [
"Tensin_PTEN_phosphatase"
] | [
10325
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3",
"R-BTA-8875513",
"R-CEL-8875513",
"R-HSA-8875513",
"R-MMU-8875513",
"R-RNO-8875513"
] | [
"EC:3.1.3",
"REACTOME:R-BTA-8875513",
"REACTOME:R-CEL-8875513",
"REACTOME:R-HSA-8875513",
"REACTOME:R-MMU-8875513",
"REACTOME:R-RNO-8875513"
] | 6 | [
"1wvh",
"2dkq",
"2gjy",
"2kno",
"2l6k",
"2loz",
"3hqc"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
5,
10320
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
113,
2,
45,
24,
31
] | 6 | true | Family | Tensin Phosphatase | Tensin Phosphatase | Tensin_PTEN_phosphatase | 8 |
IPR051485 | 51,485 | SR-related and CTD-associated factor | SR-CTD_assoc_factor | Family | 10,281 | true | false | The SR-related and CTD-associated factor family includes proteins involved in the regulation of mRNA processing and stability. Members of the family function as anti-terminator proteins, preventing early mRNA termination during transcription. They achieve this by suppressing the use of early, alternative poly(A) sites,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23140"
] | [
"SR-CTD_assoc_factor"
] | [
10281
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163",
"R-SPO-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-SPO-72163"
] | 3 | [
"2diw",
"3d9i",
"3d9j",
"3d9k",
"3d9l",
"3d9m",
"3d9n",
"3d9o",
"3d9p",
"6xkb"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10281
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
9,
2,
15,
7,
16,
10,
1,
5,
19,
1,
22
] | 11 | true | Family | SR-related and CTD-associated factor | SR-related and CTD-associated factor | SR-CTD_assoc_factor | 3 |
IPR051486 | 51,486 | Homocysteine S-methyltransferase | Hcy_S-methyltransferase | Family | 8,478 | true | false | The Homocysteine S-methyltransferase family comprises enzymes that catalyze the transfer of a methyl group from S-methylmethionine (SMM) to various substrates, including homocysteine, adenosyl-L-homocysteine (AdoMet), and selenocysteine. These enzymes play a role in the SMM cycle in plants, which is involved in the reg... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46015"
] | [
"Hcy_S-methyltransferase"
] | [
8478
] | 1 | [
"EC",
"METACYC"
] | [
"2.1.1.10",
"PWY-5441"
] | [
"EC:2.1.1.10",
"METACYC:PWY-5441"
] | 2 | [
"5dml",
"5dmm",
"5dmn"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3788,
4620,
70
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
1,
2,
13,
1,
1,
12,
27
] | 8 | true | Family | Homocysteine S-methyltransferase | Homocysteine S-methyltransferase | Hcy_S-methyltransferase | 5 |
IPR051488 | 51,488 | WD repeat-containing striatin | WD_repeat_striatin | Family | 8,800 | true | false | This family of proteins is characterized by the ability to bind calmodulin in a calcium-dependent manner, suggesting a role in calcium signaling pathways. Members are implicated in various cellular processes, including scaffolding or signaling, and may influence dendritic Ca(2+) signaling. Some proteins within this fam... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15653"
] | [
"WD_repeat_striatin"
] | [
8800
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1257604",
"R-HSA-2219530",
"R-HSA-6811558",
"R-HSA-9009391",
"R-HSA-9673766",
"R-HSA-9700645",
"R-HSA-9725370",
"R-MMU-1257604",
"R-MMU-6811558",
"R-MMU-9009391",
"R-RNO-1257604",
"R-RNO-6811558",
"R-RNO-9009391"
] | [
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-2219530",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-9009391",
"REACTOME:R-HSA-9673766",
"REACTOME:R-HSA-9700645",
"REACTOME:R-HSA-9725370",
"REACTOME:R-MMU-1257604",
"REACTOME:R-MMU-6811558",
"REACTOME:R-MMU-9009391",
"REACTOME:R-RNO-1257604",
"REACTOM... | 13 | [
"4n6j",
"6iur",
"7k36"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8800
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
8,
5,
23,
18,
1,
18,
1,
1
] | 9 | true | Family | WD repeat-containing striatin | WD repeat-containing striatin | WD_repeat_striatin | 4 |
IPR051489 | 51,489 | Disintegrin and Metalloproteinase Domain-Containing | ADAM_Metalloproteinase | Family | 9,091 | true | false | The Disintegrin and metalloproteinase domain-containing (ADAM) protein family includes transmembrane metalloproteases involved in the ectodomain shedding of various transmembrane proteins, including cytokines, adhesion proteins, and growth factor precursors. These proteases are essential for development, tissue homeost... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45702"
] | [
"ADAM_Metalloproteinase"
] | [
9091
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.24",
"R-BTA-1474228",
"R-BTA-381426",
"R-BTA-6798695",
"R-BTA-8957275",
"R-CEL-381426",
"R-CEL-6798695",
"R-CEL-8957275",
"R-HSA-1251985",
"R-HSA-1442490",
"R-HSA-1474228",
"R-HSA-177929",
"R-HSA-193692",
"R-HSA-2122948",
"R-HSA-2644606",
"R-HSA-2660826",
"R-HSA-2691232",
"R-H... | [
"EC:3.4.24",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8957275",
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-8957275",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-1442490",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-177929"... | 48 | [
"1bkc",
"1zxc",
"2a8h",
"2ao7",
"2ddf",
"2fv5",
"2fv9",
"2i47",
"2oi0",
"3b92",
"3cki",
"3e8r",
"3edz",
"3ewj",
"3g42",
"3kmc",
"3kme",
"3l0t",
"3l0v",
"3le9",
"3lea",
"3lgp",
"3o64",
"5l0q",
"6bdz",
"6be6",
"8esv",
"8gh4",
"8snl",
"8snm",
"8snn",
"8sno"... | 35 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Methanomicrobia",
"Pseudomonadati"
] | [
9065,
17,
9
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
17,
11,
17,
14,
8
] | 6 | true | Family | Disintegrin and Metalloproteinase Domain-Containing | Disintegrin and Metalloproteinase Domain-Containing | ADAM_Metalloproteinase | 8 |
IPR051490 | 51,490 | THEM6/lcsJ thioesterase | THEM6_lcsJ_thioesterase | Family | 7,177 | true | false | The THEM6/lcsJ thioesterase family is involved in the biosynthesis of various bioactive compounds, including oxaleimides, lipopeptide antibiotics, and linear lipopeptides. Members of this family function as thioesterases, playing a crucial role in the processing and maturation of secondary metabolites. They participate... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12475"
] | [
"THEM6_lcsJ_thioesterase"
] | [
7177
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
2642,
4509,
26
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
4,
3,
1,
1,
2,
1
] | 7 | true | Family | THEM6/lcsJ thioesterase | THEM6/lcsJ thioesterase | THEM6_lcsJ_thioesterase | 3 |
IPR051491 | 51,491 | Site-specific recombinase/transposase-related | Recombinase/Transposase-rel | Family | 5,143 | true | false | This family of proteins includes enzymes involved in site-specific recombination and transposition processes. Members of this family function as resolvases, catalyzing the resolution of cointegrated replicons to produce the final transposition products. These proteins are also related to transposases, which are enzymes... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36172"
] | [
"Recombinase/Transposase-rel"
] | [
5143
] | 1 | [] | [] | [] | 0 | [
"3ilx",
"3lhf",
"6dgb",
"8iaz",
"9b0l"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
364,
3936,
544,
191,
108
] | 5 | [] | [] | 0 | true | Family | Site-specific recombinase/transposase-related | Site-specific recombinase/transposase-related | Recombinase/Transposase-rel | 1 |
IPR051492 | 51,492 | Dynamin-binding and Rho GEF | Dynamin-Rho_GEF | Family | 7,251 | true | false | The Dynamin-binding protein family is characterized by its role as guanine nucleotide exchange factors (GEFs), primarily for CDC42, influencing various intracellular processes. Family members are involved in the organization of the actin and microtubule cytoskeleton, regulation of apical junctions, and spindle orientat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22834"
] | [
"Dynamin-Rho_GEF"
] | [
7251
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-9013148",
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-9013148",
"R-MMU-193648",
"R-MMU-416482",
"R-MMU-9013148",
"R-RNO-193648",
"R-RNO-416482",
"R-RNO-9013148",
"R-SCE-416482",
"R-SCE-9013148",
"R-SPO-416482",
"R-SPO-9013148"
] | [
"REACTOME:R-DRE-9013148",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-9013148",
"REACTOME:R-MMU-193648",
"REACTOME:R-MMU-416482",
"REACTOME:R-MMU-9013148",
"REACTOME:R-RNO-193648",
"REACTOME:R-RNO-416482",
"REACTOME:R-RNO-9013148",
"REACTOME:R-SCE-416482",
"REACTOME:R-SCE... | 14 | [
"1ug1",
"1uhc",
"4cc2",
"4cc3",
"4cc4",
"4cc7",
"4glm"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
24,
7227
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
20,
11,
12,
1,
13,
1,
2
] | 8 | true | Family | Dynamin-binding and Rho GEF | Dynamin-binding and Rho GEF | Dynamin-Rho_GEF | 2 |
IPR051493 | 51,493 | Chromodomain-helicase-DNA-binding | CHD | Family | 8,329 | true | false | The CHD family proteins are ATP-dependent chromatin remodelers that regulate transcription by altering chromatin structure. They are involved in various cellular processes including transcriptional repression and activation, chromatin boundary establishment, and co-transcriptional RNA processing. Members of the family ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46850"
] | [
"CHD"
] | [
8329
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.-",
"PWY-7250",
"R-DRE-3769402",
"R-HSA-1368108",
"R-HSA-1989781",
"R-HSA-2151201",
"R-HSA-2426168",
"R-HSA-3769402",
"R-HSA-381340",
"R-HSA-400206",
"R-HSA-9707564",
"R-HSA-9707616",
"R-HSA-9818027",
"R-HSA-9931509",
"R-HSA-9933387",
"R-MMU-3769402",
"R-MMU-400206",
"R-MMU-... | [
"EC:3.6.4.-",
"METACYC:PWY-7250",
"REACTOME:R-DRE-3769402",
"REACTOME:R-HSA-1368108",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-400206",
"REACTOME:R-HSA-9707564",
"REACTOME:R-HSA-9707616",
... | 20 | [
"2cka",
"2ckc",
"2dl6",
"2epb",
"2v0e",
"2v0f"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
8328,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
8,
32,
22,
17
] | 5 | true | Family | Chromodomain-helicase-DNA-binding | Chromodomain-helicase-DNA-binding | CHD | 9 |
IPR051496 | 51,496 | H-rev107 Phospholipase/Acyltransferase | H-rev107_PLA/AT | Family | 6,073 | true | false | The H-rev107 family proteins are multifunctional enzymes with both phospholipase A1/2 and acyltransferase activities. They catalyze the calcium-independent release of fatty acids from glycerophospholipids at the sn-1 or sn-2 position, with a higher activity for PLA1 over PLA2 for most substrates. Additionally, they exh... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13943"
] | [
"H-rev107_PLA/AT"
] | [
6073
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METAC... | [
"2.3.1.-",
"3.1.1.32",
"3.1.1.4",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",... | [
"EC:2.3.1.-",
"EC:3.1.1.32",
"EC:3.1.1.4",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"MET... | 252 | [
"2kyt",
"2lkt",
"2my9",
"4dot",
"4dpz",
"4fa0",
"4q95",
"7c3z",
"7zom",
"7zot"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Picornavirales",
"bioreactor metagenome"
] | [
1052,
5018,
2,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
10,
7,
10
] | 4 | true | Family | H-rev107 Phospholipase/Acyltransferase | H-rev107 Phospholipase/Acyltransferase | H-rev107_PLA/AT | 8 |
IPR051497 | 51,497 | Developmental and Hematopoietic Transcription Factors | Dev/Hematopoietic_TF | Family | 6,964 | true | false | The protein family is comprised of transcription factors that play crucial roles in developmental processes, hematopoiesis, and immune system function. Members of the family are involved in the regulation of gene expression by binding to specific DNA motifs, such as the 5'-TGACCA-3' sequence, and may act as transcripti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45993"
] | [
"Dev/Hematopoietic_TF"
] | [
6964
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-210671",
"R-DME-9933946",
"R-DME-9934037",
"R-HSA-9700645",
"R-HSA-9725370",
"R-HSA-9933946",
"R-HSA-9934037",
"R-MMU-9933946",
"R-MMU-9934037"
] | [
"REACTOME:R-DME-210671",
"REACTOME:R-DME-9933946",
"REACTOME:R-DME-9934037",
"REACTOME:R-HSA-9700645",
"REACTOME:R-HSA-9725370",
"REACTOME:R-HSA-9933946",
"REACTOME:R-HSA-9934037",
"REACTOME:R-MMU-9933946",
"REACTOME:R-MMU-9934037"
] | 9 | [
"2dmd",
"6ki6",
"6u9q",
"8dtn",
"8dtu",
"8tho",
"8tlo",
"9e6r",
"9e6s",
"9e6t"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Geopseudomonas aromaticivorans"
] | [
6963,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
37,
11,
34,
8,
18
] | 6 | true | Family | Developmental and Hematopoietic Transcription Factors | Developmental and Hematopoietic Transcription Factors | Dev/Hematopoietic_TF | 6 |
IPR051499 | 51,499 | Phosducin-like regulator | Phosducin-like_reg | Family | 5,901 | true | false | This family of proteins is involved in various cellular processes, including the regulation of visual phototransduction and the integration of photoreceptor metabolism. Members of this family function as co-chaperones for CCT in the assembly of heterotrimeric G protein complexes and facilitate the assembly of Gbeta-Gga... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46052"
] | [
"Phosducin-like_reg"
] | [
5901
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6814122",
"R-DME-6814122",
"R-HSA-6814122",
"R-MMU-6814122",
"R-RNO-6814122"
] | [
"REACTOME:R-BTA-6814122",
"REACTOME:R-DME-6814122",
"REACTOME:R-HSA-6814122",
"REACTOME:R-MMU-6814122",
"REACTOME:R-RNO-6814122"
] | 5 | [
"1a0r",
"1b9x",
"1b9y",
"2trc",
"8sff",
"8sg8",
"8sgc",
"8sh9",
"8sha",
"8shf",
"8shg",
"8shl",
"8sho",
"8shp",
"8shq",
"8sht"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5901
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
4,
1,
5,
7,
1,
9
] | 7 | true | Family | Phosducin-like regulator | Phosducin-like regulator | Phosducin-like_reg | 5 |
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