interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051500 | 51,500 | cTAGE and MIA/OTOR | cTAGE_MIA/OTOR | Family | 5,871 | true | false | The cTAGE and MIA/OTOR family proteins are involved in the transport of large cargos from the endoplasmic reticulum (ER) to the Golgi apparatus. They facilitate the incorporation of these cargos into membrane-bound carriers, particularly those too bulky for standard COPII-coated vesicles. Key functions include the spec... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23158"
] | [
"cTAGE_MIA/OTOR"
] | [
5871
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-381426",
"R-DME-5694530",
"R-DME-8957275",
"R-HSA-381426",
"R-HSA-5694530",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-5694530",
"R-MMU-8957275"
] | [
"REACTOME:R-DME-381426",
"REACTOME:R-DME-5694530",
"REACTOME:R-DME-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-5694530",
"REACTOME:R-MMU-8957275"
] | 9 | [
"7r3m"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
5862
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
22,
2,
23,
20,
20
] | 5 | true | Family | cTAGE and MIA/OTOR | cTAGE and MIA/OTOR | cTAGE_MIA/OTOR | 2 |
IPR051501 | 51,501 | Eukaryotic initiation factor 2B subunits alpha/beta/delta | eIF2B_alpha/beta/delta | Family | 5,257 | true | false | This family of proteins includes eukaryotic initiation factor 2B (eIF2B) subunits alpha, beta, and delta. These proteins form part of the eIF2B complex, which is essential for protein synthesis initiation. The complex catalyzes the exchange of GDP for GTP on the eIF2 gamma subunit, a critical step in the formation of t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45860"
] | [
"eIF2B_alpha/beta/delta"
] | [
5257
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72731",
"R-CEL-72731",
"R-DDI-72731",
"R-HSA-72731",
"R-MMU-72731",
"R-RNO-72731",
"R-SCE-72731",
"R-SPO-72731"
] | [
"REACTOME:R-BTA-72731",
"REACTOME:R-CEL-72731",
"REACTOME:R-DDI-72731",
"REACTOME:R-HSA-72731",
"REACTOME:R-MMU-72731",
"REACTOME:R-RNO-72731",
"REACTOME:R-SCE-72731",
"REACTOME:R-SPO-72731"
] | 8 | [
"1vb5",
"3ecs",
"5b04",
"6caj",
"6ezo",
"6i3m",
"6i7t",
"6jly",
"6jlz",
"6k71",
"6k72",
"6o81",
"6o85",
"6o9z",
"6qg0",
"6qg1",
"6qg2",
"6qg3",
"6qg5",
"6qg6",
"7d43",
"7d44",
"7d45",
"7d46",
"7f64",
"7f66",
"7f67",
"7kma",
"7kmf",
"7l70",
"7l7g",
"7rlo"... | 35 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
131,
71,
5046,
9
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
1,
2,
2,
3,
4,
1,
5,
6,
1,
1,
6
] | 12 | true | Family | Eukaryotic initiation factor 2B subunits alpha/beta/delta | Eukaryotic initiation factor 2B subunits alpha/beta/delta | eIF2B_alpha/beta/delta | 3 |
IPR051502 | 51,502 | Receptor-like Defense Trigger | RLP_Defense_Trigger | Family | 6,713 | true | false | This family of proteins is involved in plant defense mechanisms. Members of this family act as receptors that recognize specific pathogen-associated molecular patterns (PAMPs) or microbe-associated molecular patterns (MAMPs), triggering immune responses. These responses can include the release of reactive oxygen specie... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48062"
] | [
"RLP_Defense_Trigger"
] | [
6713
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
26,
6682,
5
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
69,
27,
7
] | 3 | true | Family | Receptor-like Defense Trigger | Receptor-like Defense Trigger | RLP_Defense_Trigger | 4 |
IPR051503 | 51,503 | Complement System Regulators and Virion Entry Mediators | ComplSys_Reg/VirEntry_Med | Family | 5,643 | true | false | The protein family is involved in the regulation of the complement system, a critical component of the innate immune response. Members of the family include glycoproteins that inhibit complement activation on self cells by binding to specific markers, accelerating the decay of C3 convertase, and acting as cofactors for... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45785"
] | [
"ComplSys_Reg/VirEntry_Med"
] | [
5643
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140875",
"R-HSA-977606",
"R-MMU-140875",
"R-MMU-977606"
] | [
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-140875",
"REACTOME:R-MMU-977606"
] | 4 | [
"1haq",
"1hfh",
"1hfi",
"2bzm",
"2g7i",
"2ic4",
"2jgw",
"2jgx",
"2kms",
"2qfh",
"2uwn",
"2v8e",
"2w80",
"2w81",
"2xqw",
"2yby",
"3gau",
"3gav",
"3gaw",
"3kxv",
"3kzj",
"3oxu",
"3r62",
"3rj3",
"3sw0",
"3zd1",
"3zd2",
"4ayd",
"4aye",
"4ayi",
"4aym",
"4b2r"... | 50 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses"
] | [
5513,
130
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
15,
56,
26,
31
] | 5 | true | Family | Complement System Regulators and Virion Entry Mediators | Complement System Regulators and Virion Entry Mediators | ComplSys_Reg/VirEntry_Med | 4 |
IPR051504 | 51,504 | Plant secondary metabolite acyltransferase | Plant_metabolite_acyltrans | Family | 7,064 | true | false | This family of proteins is involved in the modification of plant secondary metabolites through the transfer of acyl groups from donor molecules such as malonyl-CoA, coumaroyl-CoA, and other acyl-CoAs to acceptor molecules, which are often phenolic glucosides or anthocyanins. These modifications typically involve the ad... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31625"
] | [
"Plant_metabolite_acyltrans"
] | [
7064
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"2e1t",
"2e1u",
"2e1v",
"2xr7",
"7dev",
"7dex"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7064
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
65,
80,
32
] | 3 | true | Family | Plant secondary metabolite acyltransferase | Plant secondary metabolite acyltransferase | Plant_metabolite_acyltrans | 5 |
IPR051505 | 51,505 | C-type lectin domain-containing protein | C-type_lectin_domain | Family | 5,361 | true | false | This family of proteins includes receptors and elements of receptor complexes involved in various biological processes. Members of this family have roles in the immune system, such as mediating phagocytosis enhancement and functioning as receptors for defense collagens and pulmonary surfactant proteins. Some are implic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14789"
] | [
"C-type_lectin_domain"
] | [
5361
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 3 | [
"8a59",
"8ivd"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5361
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
18,
15,
16
] | 5 | true | Family | C-type lectin domain-containing protein | C-type lectin domain-containing protein | C-type_lectin_domain | 2 |
IPR051506 | 51,506 | Atos Homolog Transcription Regulators | ATOS_Transcription_Regulators | Family | 5,439 | true | false | The ATOS family comprises transcription regulators that synchronize transcriptional and translational programs to promote macrophage invasion of tissues. Members of the family contain transactivation domains (TADs), which are essential for the transcriptional activation of a subset of target genes. The family plays a c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13199"
] | [
"ATOS_Transcription_Regulators"
] | [
5439
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5439
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Ze... | [
15,
18,
3,
6,
5,
1,
14,
7,
1,
21
] | 10 | true | Family | Atos Homolog Transcription Regulators | Atos Homolog Transcription Regulators | ATOS_Transcription_Regulators | 6 |
IPR051508 | 51,508 | Mitochondrial Carrier Antiporter | Mito_Carrier_Antiporter | Family | 4,561 | true | false | This family of proteins includes mitochondrial carriers that function as antiporters, exchanging dicarboxylates and sulfur oxoanions across the inner mitochondrial membrane. Some members are implicated in the transport of specific metabolites such as oxaloacetate and sulfate, and may play roles in metabolic pathways li... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45928"
] | [
"Mito_Carrier_Antiporter"
] | [
4561
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4561
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
6,
5,
2,
3,
1,
10,
1,
1
] | 8 | true | Family | Mitochondrial Carrier Antiporter | Mitochondrial Carrier Antiporter | Mito_Carrier_Antiporter | 5 |
IPR051509 | 51,509 | GPCR with Orphan and Phoenixin-Mediated Functions | GPCR_Orphan/Phoenixin | Family | 4,061 | true | false | This family of proteins includes G-protein coupled receptors (GPCRs) with diverse functions. Some members are orphan receptors, which are GPCRs with unknown endogenous ligands, and are potential candidates for amine-like GPCR activity. Other members are known to function as receptors for the SMIM20-derived peptides Pho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19268"
] | [
"GPCR_Orphan/Phoenixin"
] | [
4061
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-418555",
"R-MMU-418555"
] | [
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-418555"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4061
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
10,
5,
9
] | 4 | true | Family | GPCR with Orphan and Phoenixin-Mediated Functions | GPCR with Orphan and Phoenixin-Mediated Functions | GPCR_Orphan/Phoenixin | 4 |
IPR051510 | 51,510 | Superkiller complex protein 8 | SKI8 | Family | 4,471 | true | false | The SKI8 family proteins are multifunctional components of both the PAF1 complex (PAF1C) and the SKI complex. In the PAF1C, they play a crucial role in transcriptional regulation by RNA polymerase II, influencing development, stem cell pluripotency, and hematopoiesis. They interact with the polymerase's CTD in both pho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44090"
] | [
"SKI8"
] | [
4471
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-429958",
"R-BTA-674695",
"R-BTA-75955",
"R-BTA-8866654",
"R-DDI-429958",
"R-HSA-112382",
"R-HSA-429958",
"R-HSA-674695",
"R-HSA-75955",
"R-HSA-8866654",
"R-MMU-112382",
"R-MMU-429958",
"R-MMU-674695",
"R-MMU-75955",
"R-MMU-8866654",
"R-RNO-112382",
"R-RNO-429958",
"R-RNO-674... | [
"REACTOME:R-BTA-429958",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-75955",
"REACTOME:R-BTA-8866654",
"REACTOME:R-DDI-429958",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-429958",
"REACTOME:R-HSA-674695",
"REACTOME:R-HSA-75955",
"REACTOME:R-HSA-8866654",
"REACTOME:R-MMU-112382",
"REACTOME:R-MMU-429... | 27 | [
"1s4u",
"1sq9",
"3ow8",
"4buj",
"5mc6",
"6gmh",
"6ted",
"7oop",
"7opc",
"7opd",
"7qdr",
"7qds",
"7qdy",
"7qdz",
"7unc",
"7und",
"8a3y",
"8q9t",
"8qca",
"8qcb",
"8urq",
"8uru",
"9egx",
"9egy",
"9egz",
"9eh0",
"9eh1",
"9eh2",
"9g8o",
"9g8q",
"9g8r",
"9hvq"... | 35 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megamimivirinae",
"hydrothermal vent metagenome"
] | [
53,
4415,
2,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
3,
1,
1,
7,
7,
1,
3,
6,
2,
1,
3
] | 12 | true | Family | Superkiller complex protein 8 | Superkiller complex protein 8 | SKI8 | 4 |
IPR051511 | 51,511 | Mitochondrial Quality Control and Scaffold Kinases | MitoQC_Scaffold_Kinases | Family | 4,180 | true | false | The protein family includes both catalytically inactive kinases acting as scaffold proteins and active serine/threonine-protein kinases involved in mitochondrial quality control. The inactive kinases function as effectors of small GTPases, regulate cell morphology and motility, and coactivate Notch signaling. The activ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22972"
] | [
"MitoQC_Scaffold_Kinases"
] | [
4180
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5205685",
"R-DME-5205685",
"R-HSA-5205685",
"R-HSA-9013420",
"R-HSA-9013424",
"R-HSA-9614657",
"R-HSA-9696270",
"R-MMU-5205685",
"R-MMU-9013420",
"R-MMU-9013424",
"R-MMU-9696270",
"R-RNO-5205685",
"R-RNO-9696270"
] | [
"REACTOME:R-CEL-5205685",
"REACTOME:R-DME-5205685",
"REACTOME:R-HSA-5205685",
"REACTOME:R-HSA-9013420",
"REACTOME:R-HSA-9013424",
"REACTOME:R-HSA-9614657",
"REACTOME:R-HSA-9696270",
"REACTOME:R-MMU-5205685",
"REACTOME:R-MMU-9013420",
"REACTOME:R-MMU-9013424",
"REACTOME:R-MMU-9696270",
"REACTOM... | 13 | [
"5oat",
"5ve6",
"5yj9",
"6bhc",
"6eqi",
"6ewx",
"7mp8",
"7mp9",
"7t3x",
"7t4k",
"7t4l",
"7t4m",
"7t4n",
"8dp5",
"8ds6",
"8uct",
"8udc",
"8uyf",
"8uyh",
"8uyi",
"9eih",
"9eii",
"9eij",
"9kmr",
"9kox",
"9kqn"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4180
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
4,
8,
11,
8
] | 6 | true | Family | Mitochondrial Quality Control and Scaffold Kinases | Mitochondrial Quality Control and Scaffold Kinases | MitoQC_Scaffold_Kinases | 8 |
IPR051512 | 51,512 | Inactive Rhomboid | Inactive_Rhomboid | Family | 4,197 | true | false | The Inactive Rhomboid Protein family is characterized by members that regulate the ADAM17 protease, which is responsible for shedding epidermal growth factor (EGF) receptor ligands and TNF. Although members of this family are structurally related to peptidases, they do not exhibit proteolytic activity. Instead, they mo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45965"
] | [
"Inactive_Rhomboid"
] | [
4197
] | 1 | [
"REACTOME"
] | [
"R-HSA-9662834"
] | [
"REACTOME:R-HSA-9662834"
] | 1 | [
"8snl",
"8snm",
"8snn",
"8sno",
"9o58"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4197
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
6,
1,
18,
6,
7
] | 6 | true | Family | Inactive Rhomboid | Inactive Rhomboid | Inactive_Rhomboid | 1 |
IPR051514 | 51,514 | R-spondin domain-containing protein | R-spondin | Family | 4,045 | true | false | This family of proteins acts as activators of the canonical Wnt signaling pathway by serving as ligands for LGR4-6 receptors. They play a crucial role in various biological processes, including angiogenesis, embryonic development, and limb specification. By binding to their receptors, these proteins trigger the associa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46987"
] | [
"R-spondin"
] | [
4045
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-4641263",
"R-DRE-4641263",
"R-HSA-4641263",
"R-HSA-8939256",
"R-MMU-4641263",
"R-XTR-4641263"
] | [
"REACTOME:R-BTA-4641263",
"REACTOME:R-DRE-4641263",
"REACTOME:R-HSA-4641263",
"REACTOME:R-HSA-8939256",
"REACTOME:R-MMU-4641263",
"REACTOME:R-XTR-4641263"
] | 6 | [
"4bso",
"4bsp",
"4bsr",
"4bss",
"4bst",
"4bsu",
"4c8v",
"4c8w",
"4c99",
"4c9a",
"4c9e",
"4c9r",
"4c9u",
"4c9v",
"4cdk",
"4kng",
"4kt1",
"4li2",
"4qxf",
"4ufr",
"4ufs",
"8wvu",
"8xfp",
"8xfs",
"8xft",
"8xum",
"8y69",
"9kb7",
"9kb8",
"9kb9"
] | 30 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4045
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
8,
8,
12
] | 4 | true | Family | R-spondin domain-containing protein | R-spondin domain-containing protein | R-spondin | 1 |
IPR051515 | 51,515 | Immunity-related GTPase | IRG | Family | 4,305 | true | false | The IRG protein family is involved in innate immunity and inflammatory response, acting as dynamin-like GTPases that bind to intracellular membranes to promote their remodeling and trafficking. They play crucial roles in the clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosom... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32341"
] | [
"IRG"
] | [
4305
] | 1 | [
"EC"
] | [
"3.6.5.-"
] | [
"EC:3.6.5.-"
] | 1 | [
"1tpz",
"1tq2",
"1tq4",
"1tq6",
"1tqd",
"4lv5",
"4lv8",
"5fph",
"7c3k",
"7ves",
"7vex",
"8h4m",
"8h4o",
"8jqy",
"8jqz"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
133,
4169,
3
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
6,
54,
32
] | 4 | true | Family | Immunity-related GTPase | Immunity-related GTPase | IRG | 4 |
IPR051517 | 51,517 | Interferon-induced transmembrane antiviral protein | IFITM_antiviral_protein | Family | 3,639 | true | false | This family of proteins is involved in antiviral defense mechanisms, particularly by inhibiting the entry and fusion of various enveloped viruses with host cell membranes. They act by altering intracellular cholesterol homeostasis and preventing viral fusion with cholesterol-depleted endosomes. These proteins are also ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13999"
] | [
"IFITM_antiviral_protein"
] | [
3639
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-909733",
"R-MMU-198933",
"R-RNO-198933"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-909733",
"REACTOME:R-MMU-198933",
"REACTOME:R-RNO-198933"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bilateria",
"bird metagenome"
] | [
2,
3636,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
40,
11,
18
] | 4 | true | Family | Interferon-induced transmembrane antiviral protein | Interferon-induced transmembrane antiviral protein | IFITM_antiviral_protein | 7 |
IPR051518 | 51,518 | Plant Sucrose Phosphatase | Sucrose_Phosphatase | Family | 2,838 | true | false | The sucrose phosphatase family encompasses enzymes that catalyze the hydrolysis of sucrose-6-phosphate to produce sucrose and inorganic phosphate, representing the final step in the biosynthesis of sucrose. Members of this family are critical for sucrose metabolism in plants, playing a pivotal role in energy storage an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46521"
] | [
"Sucrose_Phosphatase"
] | [
2838
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.1.3.24",
"PWY-7238",
"PWY-7347"
] | [
"EC:3.1.3.24",
"METACYC:PWY-7238",
"METACYC:PWY-7347"
] | 3 | [
"1s2o",
"1tj3",
"1tj4",
"1tj5",
"1u2s",
"1u2t",
"2b1q",
"2b1r",
"2d2v"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"ecological metagenomes"
] | [
952,
1,
1873,
12
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
7,
38
] | 3 | true | Family | Plant Sucrose Phosphatase | Plant Sucrose Phosphatase | Sucrose_Phosphatase | 5 |
IPR051519 | 51,519 | PDE6D/unc-119 myristoyl-binding | PDE6D_unc-119_myristoyl-bd | Family | 3,299 | true | false | The PDE6D/unc-119 family consists of myristoyl-binding proteins that function as cargo adapters, specifically interacting with the myristoyl moiety of a subset of N-terminally myristoylated proteins to facilitate their correct localization. Members of the family adopt an immunoglobulin-like beta-sandwich fold with a hy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12951"
] | [
"PDE6D_unc-119_myristoyl-bd"
] | [
3299
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5624138",
"R-DRE-5624138",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-CEL-5624138",
"REACTOME:R-DRE-5624138",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 4 | [
"3gqq",
"3rbq",
"4goj",
"4gok",
"5l7k",
"6h6a",
"7ok6",
"7ok7",
"7umo",
"9gkg",
"9nem",
"9odx"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3299
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
6,
11,
5,
9
] | 6 | true | Family | PDE6D/unc-119 myristoyl-binding | PDE6D/unc-119 myristoyl-binding | PDE6D_unc-119_myristoyl-bd | 4 |
IPR051520 | 51,520 | Elbow/Noc Zinc Finger | Elbow/Noc_ZnFinger | Family | 3,260 | true | false | The Elbow/Noc family comprises zinc finger proteins that function predominantly as transcriptional corepressors, which do not directly bind DNA but may regulate transcription through recruitment of histone deacetylases to gene promoters. Members of the family are involved in various developmental processes, including t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12522"
] | [
"Elbow/Noc_ZnFinger"
] | [
3260
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-212436",
"R-HSA-212436",
"R-MMU-212436"
] | [
"REACTOME:R-DME-212436",
"REACTOME:R-HSA-212436",
"REACTOME:R-MMU-212436"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3260
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
3,
4,
5,
5
] | 6 | true | Family | Elbow/Noc Zinc Finger | Elbow/Noc Zinc Finger | Elbow/Noc_ZnFinger | 2 |
IPR051521 | 51,521 | tRNA-uridine aminocarboxypropyltransferase 1/YIPF3 | DTWD1/YIPF3 | Family | 3,234 | false | false | This family of proteins includes tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) and its paralogue, YIPF3, which are involved in two distinct cellular functions. DTWD1 is responsible for the post-transcriptional modification of tRNA molecules, specifically catalysing the formation of 3-(3-amino-3-carboxypropyl)uri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15627"
] | [
""
] | [
3234
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060866",
"PUB00060867",
"PUB00093958"
] | [
"12490290",
"21757827",
"31804502"
] | [
"Characterization of a novel hematopoietic marker expressed from early embryonic hematopoietic stem cells to adult mature lineages.",
"Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip domain family proteins.",
"Biogenesis and functions of aminocarboxypropyluridine in tRNA."
] | [
2002,
2011,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3234
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3,
13,
5,
10
] | 6 | true | Family | tRNA-uridine aminocarboxypropyltransferase 1/YIPF3 | tRNA-uridine aminocarboxypropyltransferase 1/YIPF3 | DTWD1/YIPF3 | 3 |
IPR051522 | 51,522 | Iron-sulfur cluster assembly LYR protein | ISC_assembly_LYR | Family | 3,206 | true | false | This family of proteins is involved in the biosynthesis of iron-sulfur (Fe-S) clusters, which are essential cofactors for a variety of cellular enzymes. Members of this family act as stabilizing factors in the core iron-sulfur cluster (ISC) assembly complex. They regulate the activity of the cysteine desulfurase NFS1, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13166"
] | [
"ISC_assembly_LYR"
] | [
3206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1362409",
"R-BTA-9854311",
"R-BTA-9865881",
"R-DDI-1362409",
"R-DDI-9865881",
"R-DME-1362409",
"R-DME-9865881",
"R-DRE-1362409",
"R-HSA-1362409",
"R-HSA-9854311",
"R-HSA-9865881",
"R-MMU-1362409",
"R-MMU-9854311",
"R-MMU-9865881",
"R-PFA-1362409",
"R-SCE-1362409",
"R-SCE-98658... | [
"REACTOME:R-BTA-1362409",
"REACTOME:R-BTA-9854311",
"REACTOME:R-BTA-9865881",
"REACTOME:R-DDI-1362409",
"REACTOME:R-DDI-9865881",
"REACTOME:R-DME-1362409",
"REACTOME:R-DME-9865881",
"REACTOME:R-DRE-1362409",
"REACTOME:R-HSA-1362409",
"REACTOME:R-HSA-9854311",
"REACTOME:R-HSA-9865881",
"REACTOM... | 19 | [
"5usr",
"5wgb",
"5wkp",
"5wlw",
"6nzu",
"6odd",
"6uxe",
"6w1d",
"6wi2",
"6wih",
"7rtk",
"8pk8",
"8pk9",
"8pka",
"8rmc",
"8rmd",
"8rme",
"8rmf",
"8rmg",
"8tvt"
] | 20 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3206
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
2,
6,
1,
1,
3,
1,
1
] | 9 | true | Family | Iron-sulfur cluster assembly LYR protein | Iron-sulfur cluster assembly LYR protein | ISC_assembly_LYR | 4 |
IPR051523 | 51,523 | KISH domain-containing protein | KISH_domain | Family | 3,137 | true | false | This family of proteins is involved in the early part of the secretory pathway. Members of this family are characterized by their role in the transport of proteins from the endoplasmic reticulum towards the Golgi apparatus, which is a critical step in the secretion of proteins and their delivery to their proper cellula... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13229"
] | [
"KISH_domain"
] | [
3137
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3137
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
2,
1,
2,
1,
4,
5,
1,
1,
5
] | 12 | true | Family | KISH domain-containing protein | KISH domain-containing protein | KISH_domain | 9 |
IPR051524 | 51,524 | Betaine-homocysteine S-methyltransferase | BHMT | Family | 2,244 | true | false | This family of proteins is involved in the metabolic process of homocysteine regulation. Members of this family catalyse the transfer of a methyl group from betaine to homocysteine, resulting in the formation of dimethylglycine and methionine. This enzymatic activity is crucial for maintaining homocysteine levels withi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46120"
] | [
"BHMT"
] | [
2244
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.5",
"PWY-3661",
"R-DRE-1614635",
"R-DRE-6798163",
"R-HSA-1614635",
"R-HSA-6798163",
"R-MMU-1614635",
"R-MMU-6798163",
"R-RNO-1614635",
"R-RNO-6798163",
"R-XTR-1614635",
"R-XTR-6798163"
] | [
"EC:2.1.1.5",
"METACYC:PWY-3661",
"REACTOME:R-DRE-1614635",
"REACTOME:R-DRE-6798163",
"REACTOME:R-HSA-1614635",
"REACTOME:R-HSA-6798163",
"REACTOME:R-MMU-1614635",
"REACTOME:R-MMU-6798163",
"REACTOME:R-RNO-1614635",
"REACTOME:R-RNO-6798163",
"REACTOME:R-XTR-1614635",
"REACTOME:R-XTR-6798163"
] | 12 | [
"1lt7",
"1lt8",
"1umy",
"4m3p",
"8d45"
] | 5 | [] | [] | [] | [] | 0 | [
"IPR017226"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
15,
2221,
8
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
3,
10
] | 4 | true | Family | Betaine-homocysteine S-methyltransferase | Betaine-homocysteine S-methyltransferase | BHMT | 8 |
IPR051526 | 51,526 | Secreted Beta-Glucosidase SUN | Beta-Glucosidase_SUN | Family | 1,430 | true | false | The SUN family proteins are secreted beta-glucosidases involved in various cellular processes including aging, oxidative stress response, mitochondrial biogenesis, cytokinesis, cell wall biogenesis, and septation. They play roles in the host-pathogen interaction, adhesion to host tissue, and biofilm formation. Some fam... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31316"
] | [
"Beta-Glucosidase_SUN"
] | [
1430
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.2.1.-",
"PWY-1921",
"PWY-5821",
"PWY-5976",
"PWY-6527",
"PWY-6717",
"PWY-6735",
"PWY-6737",
"PWY-6749",
"PWY-6784",
"PWY-6821",
"PWY-6848",
"PWY-6855",
"PWY-6906",
"PWY-6972",
"PWY-7056",
"PWY-7057",
"PWY-7074",
"PWY-7091",
"PWY-7133",
"PWY-7134",
"PWY-7256",
"PWY-7445... | [
"EC:3.2.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5821",
"METACYC:PWY-5976",
"METACYC:PWY-6527",
"METACYC:PWY-6717",
"METACYC:PWY-6735",
"METACYC:PWY-6737",
"METACYC:PWY-6749",
"METACYC:PWY-6784",
"METACYC:PWY-6821",
"METACYC:PWY-6848",
"METACYC:PWY-6855",
"METACYC:PWY-6906",
"METACYC:PWY-6... | 31 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1430
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
1,
4,
2,
1
] | 4 | true | Family | Secreted Beta-Glucosidase SUN | Secreted Beta-Glucosidase SUN | Beta-Glucosidase_SUN | 3 |
IPR051527 | 51,527 | Killer cell lectin-like receptor subfamily B | KLR_subfamily_B | Family | 1,285 | true | false | This family of proteins includes receptors that are primarily involved in the regulation of natural killer (NK) cell cytotoxicity. Members of this family can either stimulate or inhibit NK cell activity. Some proteins in this family contain an immunoreceptor tyrosine-based inhibitor motif (ITIM), which, upon phosphoryl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46784"
] | [
"KLR_subfamily_B"
] | [
1285
] | 1 | [
"REACTOME"
] | [
"R-HSA-198933"
] | [
"REACTOME:R-HSA-198933"
] | 1 | [
"2m94",
"2mti",
"3m9z",
"3t3a",
"5j2s",
"5mgr",
"5mgs",
"5mgt",
"5tzn",
"6e7d",
"7odu"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Shearwaterpox virus"
] | [
1284,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
55,
16
] | 3 | true | Family | Killer cell lectin-like receptor subfamily B | Killer cell lectin-like receptor subfamily B | KLR_subfamily_B | 6 |
IPR051528 | 51,528 | Keratin-associated protein type 19 | KRTAP_type_19 | Family | 357 | true | false | The KRTAP type 19 family is involved in the structural integrity of hair. Members of this family are hair keratin-associated proteins (KRTAPs) that play a crucial role in the hair cortex. They are part of an interfilamentous matrix that embeds hair keratin intermediate filaments. These proteins contribute to the format... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38140"
] | [
"KRTAP_type_19"
] | [
357
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-6805567",
"R-MMU-6805567"
] | [
"REACTOME:R-HSA-6805567",
"REACTOME:R-MMU-6805567"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
357
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
10,
5
] | 3 | true | Family | Keratin-associated protein type 19 | Keratin-associated protein type 19 | KRTAP_type_19 | 7 |
IPR051529 | 51,529 | Seed Storage Prolamin | Seed_Storage_Prolamin | Family | 164 | true | false | This family of proteins includes major seed storage prolamins, which are plant storage proteins primarily found in seeds. They are rich in proline and glutamine and are typically found in the endosperm of cereals. These proteins play a crucial role in the storage of nitrogen, carbon, and sulfur for the developing seedl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48199"
] | [
"Seed_Storage_Prolamin"
] | [
164
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Paenibacillus contaminans",
"Panicoideae"
] | [
1,
163
] | 2 | [
"Zea mays"
] | [
54
] | 1 | true | Family | Seed Storage Prolamin | Seed Storage Prolamin | Seed_Storage_Prolamin | 6 |
IPR051530 | 51,530 | Metabotropic Glutamate/GABA-B Receptor-like | mGluR/GABA-B-like | Family | 87 | true | false | This family of proteins includes metabotropic glutamate receptor-like proteins that are characterized by a dual domain architecture. The N-terminal section is similar to the BMP lipoprotein family, which may suggest a role in signaling or cellular communication. The C-terminal section is akin to the G-protein coupled r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46924"
] | [
"mGluR/GABA-B-like"
] | [
87
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
87
] | 1 | [] | [] | 0 | true | Family | Metabotropic Glutamate/GABA-B Receptor-like | Metabotropic Glutamate/GABA-B Receptor-like | mGluR/GABA-B-like | 8 |
IPR051531 | 51,531 | N-acetyltransferase | N-acetyltransferase | Family | 87,821 | true | false | The acetyltransferase family is characterized by its ability to transfer acetyl groups from acetyl coenzyme A to various acceptor substrates. Members of this family, such as the RimJ subfamily, are involved in the post-translational modification of ribosomal proteins, specifically acetylating the N-terminal alanine of ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43792"
] | [
"N-acetyltransferase"
] | [
87821
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"2fsr",
"2zw4",
"2zw5",
"2zw6",
"2zw7",
"3fbu",
"3igr",
"3juw",
"6c30",
"6c32",
"6c37",
"6edd",
"6edv",
"7kpp",
"7kps",
"7kye",
"7kyj"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
687,
81659,
4742,
12,
721
] | 5 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | N-acetyltransferase | N-acetyltransferase | N-acetyltransferase | 3 |
IPR051532 | 51,532 | Diverse Ester Hydrolysis Enzymes | Ester_Hydrolysis_Enzymes | Family | 53,028 | true | false | This family of proteins includes enzymes with diverse ester hydrolysis capabilities. Members of this family are involved in the degradation of various substrates, including plant biomass components such as cellulose and xylan, as well as synthetic esters and triglycerides. Some proteins exhibit multifunctional esterase... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30383"
] | [
"Ester_Hydrolysis_Enzymes"
] | [
53028
] | 1 | [] | [] | [] | 0 | [
"1ivn",
"1j00",
"1jrl",
"1u8u",
"1v2g",
"1vjg",
"1z8h",
"2hsj",
"2vpt",
"3bzw",
"3hp4",
"3p94",
"3rjt",
"3w7v",
"4c1b",
"4h08",
"4hf7",
"4iyj",
"4jgg",
"4jhl",
"4jj4",
"4jj6",
"4jko",
"4k3u",
"4k40",
"4k7j",
"4k9s",
"4lhs",
"4oao",
"4oap",
"4ppy",
"4q7q"... | 75 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
96,
45773,
6440,
217,
502
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
286,
1,
4
] | 3 | true | Family | Diverse Ester Hydrolysis Enzymes | Diverse Ester Hydrolysis Enzymes | Ester_Hydrolysis_Enzymes | 9 |
IPR051534 | 51,534 | CBASS antivirus and pafABC operon-associated protein | CBASS_pafABC_assoc_protein | Family | 57,571 | true | false | This family of proteins includes transcriptional regulators and proteins that are part of operons but are not directly involved in pupylation or substrate degradation. Some members function as DNA-binding transcriptional repressors in CBASS antivirus systems, which provide immunity against bacteriophage infections by s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34580"
] | [
"CBASS_pafABC_assoc_protein"
] | [
57571
] | 1 | [] | [] | [] | 0 | [
"6sj9",
"7p5x",
"7qfz",
"7t8k",
"7t8l",
"7tb5",
"7tb6",
"7tzv",
"7u02",
"8tp8",
"8tpk",
"9c5g",
"9cu3",
"9fnd",
"9fne"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"IncJ plasmid R391",
"Methanobacteriota",
"Viruses",
"unclassified sequences"
] | [
56743,
26,
1,
7,
2,
792
] | 6 | [
"Arabidopsis thaliana"
] | [
3
] | 1 | true | Family | CBASS antivirus and pafABC operon-associated protein | CBASS antivirus and pafABC operon-associated protein | CBASS_pafABC_assoc_protein | 2 |
IPR051535 | 51,535 | Bacterial siderophore ABC transporter ATP-binding | Siderophore_ABC-ATPase | Family | 36,161 | true | false | This family of proteins is involved in the transport of siderophores and iron complexes across cellular membranes. Members function as ATP-binding components of ABC transporter complexes, which are responsible for the energy-dependent uptake of various iron chelates, including hydroxamate and catecholate siderophores, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42771"
] | [
"Siderophore_ABC-ATPase"
] | [
36161
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9638482"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9638482"
] | 2 | [
"7lb8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
360,
35607,
13,
181
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Bacterial siderophore ABC transporter ATP-binding | Bacterial siderophore ABC transporter ATP-binding | Siderophore_ABC-ATPase | 3 |
IPR051536 | 51,536 | Uracil-DNA glycosylase family, Type-4/5 | UDG_Type-4/5 | Family | 22,084 | true | false | The Type-4 and Type-5 uracil-DNA glycosylase family consists of enzymes that play a crucial role in DNA repair by excising uracil from DNA. This occurs as a result of cytosine deamination or misincorporation of dUMP instead of dTMP. Members of the family can process uracil in various contexts, including double-stranded... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33693"
] | [
"UDG_Type-4/5"
] | [
22084
] | 1 | [
"EC"
] | [
"3.2.2"
] | [
"EC:3.2.2"
] | 1 | [
"1l9g",
"1ui0",
"1ui1",
"1vk2",
"2d3y",
"2ddg",
"2dem",
"2dp6",
"4zbx",
"4zby",
"4zbz",
"6ail",
"6ajo",
"6ajp",
"6ajq",
"6ajr",
"6ajs",
"6io9",
"6ioa",
"6iob",
"6ioc",
"6iod",
"6l5a",
"6l5b",
"6l6s",
"8iie",
"8iif",
"8iig",
"8iih",
"8iii",
"8iij",
"8iil"... | 40 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1793,
19404,
12,
67,
808
] | 5 | [] | [] | 0 | true | Family | Uracil-DNA glycosylase family, Type-4/5 | Uracil-DNA glycosylase family, Type-4/5 | UDG_Type-4/5 | 7 |
IPR051537 | 51,537 | DNA Adenine N(4)/N(6)-Methyltransferase | DNA_Adenine_Mtase | Family | 27,184 | true | false | The N(4)/N(6)-methyltransferase family is involved in the methylation of adenine residues within specific DNA sequences, which is crucial for the protection of genomic DNA from cleavage by restriction enzymes. Members of this family function as part of type I restriction-modification systems, which are composed of meth... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42933"
] | [
"DNA_Adenine_Mtase"
] | [
27184
] | 1 | [
"EC"
] | [
"2.1.1.72"
] | [
"EC:2.1.1.72"
] | 1 | [
"2ar0",
"2okc",
"2y7c",
"2y7h",
"3lkd",
"3ufb",
"5ybb",
"7bst",
"7bto",
"7btp",
"7btq",
"7btr",
"7eew",
"7vru",
"7vs4"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
684,
25956,
71,
67,
406
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA Adenine N(4)/N(6)-Methyltransferase | DNA Adenine N(4)/N(6)-Methyltransferase | DNA_Adenine_Mtase | 7 |
IPR051538 | 51,538 | Acyl-CoA Synthetase/Transferase | Acyl-CoA_Synth/Transferase | Family | 9,844 | true | false | This family of proteins includes enzymes that catalyze the formation of acyl-CoA esters from various substrates, utilizing ATP and releasing ADP and phosphate. Members of this family are involved in central metabolic processes, such as the degradation of branched-chain amino acids and the conversion of acetyl-CoA to ac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43334"
] | [
"Acyl-CoA_Synth/Transferase"
] | [
9844
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.2.1.13",
"PWY-5483",
"PWY-5535",
"PWY-8305"
] | [
"EC:6.2.1.13",
"METACYC:PWY-5483",
"METACYC:PWY-5535",
"METACYC:PWY-8305"
] | 4 | [
"1wr2",
"2csu",
"4xyl",
"4xym",
"4xz3",
"4y8v",
"4yaj",
"4yak",
"4yb8",
"4ybz",
"5hbr",
"7cm9",
"8wzu",
"9y43"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
1752,
7277,
203,
1,
611
] | 5 | [] | [] | 0 | true | Family | Acyl-CoA Synthetase/Transferase | Acyl-CoA Synthetase/Transferase | Acyl-CoA_Synth/Transferase | 6 |
IPR051539 | 51,539 | Type IV secretion system coupling protein TraD/TraG/VirD4-like | T4SS-coupling_proteins | Family | 27,165 | true | true | This family of proteins is involved in the conjugative transfer of plasmid DNA between bacterial cells, a process central to the propagation of antibiotic resistance and virulence factors. Members of this family are known to interact with relaxase enzymes and may form a pore-like structure to facilitate the transfer of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37937"
] | [
"T4SS-coupling_protein"
] | [
27165
] | 1 | [] | [] | [] | 0 | [
"1e9r",
"1e9s",
"1gki",
"1gl6",
"1gl7",
"6jho",
"8dol"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"plasmids",
"unclassified sequences"
] | [
78,
26662,
6,
79,
10,
330
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type IV secretion system coupling protein TraD/TraG/VirD4-like | Type IV secretion system coupling protein TraD/TraG/VirD4-like | T4SS-coupling_proteins | 6 |
IPR051540 | 51,540 | S-2-haloalkanoic acid dehalogenase | S-2-haloacid_dehalogenase | Family | 27,460 | true | true | This family of proteins includes enzymes that catalyze the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids, producing the corresponding (R)-2-hydroxyalkanoic acids. These enzymes are active on short-chain acids, ranging from C(2) to C(4), and they operate with inversion of configuration at the second carbon... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43316"
] | [
"S-2-haloacid_dehalogenase"
] | [
27460
] | 1 | [
"EC",
"METACYC"
] | [
"3.8.1.2",
"PWY-7425"
] | [
"EC:3.8.1.2",
"METACYC:PWY-7425"
] | 2 | [
"1aq6",
"1jud",
"1qh9",
"1qq5",
"1qq6",
"1qq7",
"1x42",
"1zrm",
"1zrn",
"2no4",
"2no5",
"2om6",
"2pke",
"2w11",
"2w43",
"2yml",
"2ymm",
"2ymp",
"2ymq",
"2yn4",
"3ddh",
"3smv",
"3u26",
"3um9",
"3umb",
"3umc",
"3umg",
"4ce6",
"4cf3",
"4cf4",
"4cf5",
"4cnq"... | 64 | [] | [] | [] | [] | 0 | [
"IPR006439"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
842,
20174,
13,
6126,
305
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | S-2-haloalkanoic acid dehalogenase | S-2-haloalkanoic acid dehalogenase | S-2-haloacid_dehalogenase | 7 |
IPR051541 | 51,541 | PTS System Sugar Transport and Nitrogen Regulation | PTS_SugarTrans_NitroReg | Family | 19,395 | true | false | The protein family is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which is a key carbohydrate active transport system. Members of the family catalyze the phosphorylation of sugar substrates during their translocation across the cell membrane. Specific components of this family a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47738"
] | [
"PTS_SugarTrans_NitroReg"
] | [
19395
] | 1 | [] | [] | [] | 0 | [
"1a6j",
"1xiz",
"2a0j",
"3lf6",
"3t43",
"3urr",
"4gqx",
"4m62",
"4m8q",
"4odx",
"5sy8",
"5t29",
"5t5b",
"5t6l",
"5t80",
"5t85",
"5tfw",
"6mto",
"6mtq",
"8sx3",
"8tzn",
"8tzw",
"8u03",
"8u08",
"8v2e",
"9bdh",
"9bdi"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
19014,
7,
129,
245
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | PTS System Sugar Transport and Nitrogen Regulation | PTS System Sugar Transport and Nitrogen Regulation | PTS_SugarTrans_NitroReg | 3 |
IPR051542 | 51,542 | Hydrogenase-associated cytochrome | Hydrogenase_cytochrome | Family | 14,539 | true | false | This family of proteins includes components involved in electron transfer processes and redox reactions. Members are typically associated with the catalysis of reactions involving hydrogen or thiosulfate, often with a role in energy metabolism. Some proteins in this family function as b-type cytochromes, which are invo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30485"
] | [
"Hydrogenase_cytochrome"
] | [
14539
] | 1 | [] | [] | [] | 0 | [
"4gd3",
"6g94"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
98,
14228,
7,
206
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Hydrogenase-associated cytochrome | Hydrogenase-associated cytochrome | Hydrogenase_cytochrome | 7 |
IPR051543 | 51,543 | Serine Peptidase S9A Subfamily | Serine_Peptidase_S9A | Family | 16,816 | true | false | This family of proteins includes serine peptidases that exhibit a range of substrate specificities and biological functions. Some members are known to cleave peptide bonds on the C-terminal side of lysyl and argininyl residues, while others do not cleave after arginine or lysine residues. Functions of these proteins in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11757"
] | [
"Serine_Peptidase_S9A"
] | [
16816
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [
"2xe4",
"4bp8",
"4bp9",
"7ne4",
"7ne5",
"7ne7",
"7ob1",
"7obm",
"7ywp",
"7yws",
"7ywz",
"7yx7",
"7zjz",
"8ono",
"8rfb"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote KM3_17_C07"
] | [
11722,
4873,
220,
1
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
21,
2,
1,
3,
5,
11,
6,
48
] | 8 | true | Family | Serine Peptidase S9A Subfamily | Serine Peptidase S9A Subfamily | Serine_Peptidase_S9A | 7 |
IPR051544 | 51,544 | Two-partner secretion system outer membrane transporter | TPS_OM_transporter | Family | 13,932 | true | false | This family of proteins is involved in a two-partner secretion (TPS) system, which is a mechanism for the transport of large proteins across the outer membrane of Gram-negative bacteria. Members of this family function as the outer membrane component, forming a beta-barrel structure that facilitates the translocation o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34597"
] | [
"TPS_OM_transporter"
] | [
13932
] | 1 | [] | [] | [] | 0 | [
"2mhj",
"3njt",
"4qky",
"4ql0",
"6wil",
"6wim"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctvyM23",
"unclassified sequences"
] | [
13779,
29,
1,
123
] | 4 | [] | [] | 0 | true | Family | Two-partner secretion system outer membrane transporter | Two-partner secretion system outer membrane transporter | TPS_OM_transporter | 8 |
IPR051545 | 51,545 | NAD(P)H dehydrogenase (quinone) | NAD(P)H_dehydrogenase_qn | Family | 15,956 | true | false | The NAD(P)H dehydrogenase (quinone) family comprises enzymes that catalyze the two-electron reduction of quinones to hydroquinones. These enzymes utilize NADH or NADPH as electron donors in a ping-pong kinetic mechanism, transferring electrons to a flavin cofactor and then to the quinone, avoiding semiquinone and react... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10204"
] | [
"NAD(P)H_dehydrogenase_qn"
] | [
15956
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-211945",
"R-HSA-350562",
"R-HSA-9818027",
"R-MMU-211945",
"R-MMU-350562",
"R-RNO-211945",
"R-RNO-350562"
] | [
"REACTOME:R-HSA-211945",
"REACTOME:R-HSA-350562",
"REACTOME:R-HSA-9818027",
"REACTOME:R-MMU-211945",
"REACTOME:R-MMU-350562",
"REACTOME:R-RNO-211945",
"REACTOME:R-RNO-350562"
] | 7 | [
"1d4a",
"1dxo",
"1dxq",
"1gg5",
"1h66",
"1h69",
"1kbo",
"1kbq",
"1qbg",
"1qr2",
"1qrd",
"1sg0",
"1xi2",
"1zx1",
"2bzs",
"2f1o",
"2qmy",
"2qmz",
"2qr2",
"2qwx",
"2qx4",
"2qx6",
"2qx8",
"2qx9",
"3fw1",
"3g5m",
"3gam",
"3jsx",
"3lcm",
"3nfr",
"3nhf",
"3nhj"... | 100 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
112,
13165,
2567,
112
] | 4 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
13,
8,
8
] | 5 | true | Family | NAD(P)H dehydrogenase (quinone) | NAD(P)H dehydrogenase (quinone) | NAD(P)H_dehydrogenase_qn | 4 |
IPR051546 | 51,546 | Class-II Aspartate Ammonia-Lyase | Aspartate_Ammonia-Lyase | Family | 12,756 | true | false | This family of proteins includes aspartate ammonia-lyases, which catalyze the reversible deamination of L-aspartate to fumarate and ammonia, an important reaction in the nitrogen metabolism of cells. Members of this family are involved in the biosynthesis and degradation of amino acids, playing a key role in the metabo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42696"
] | [
"Aspartate_Ammonia-Lyase"
] | [
12756
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.3.1.1",
"PWY-8291",
"PWY-8294",
"PWY-8419"
] | [
"EC:4.3.1.1",
"METACYC:PWY-8291",
"METACYC:PWY-8294",
"METACYC:PWY-8419"
] | 4 | [
"1j3u",
"1jsw",
"3oce",
"3ocf",
"3r6q",
"3r6v",
"3r6y",
"6wng",
"8rj0",
"8rj1"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
151,
12285,
177,
143
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Family | Class-II Aspartate Ammonia-Lyase | Class-II Aspartate Ammonia-Lyase | Aspartate_Ammonia-Lyase | 5 |
IPR051547 | 51,547 | Tyrosyl-DNA phosphodiesterase 2-like | TDP2-like | Family | 11,370 | true | false | This family of proteins functions primarily in DNA repair, specifically by removing covalent adducts from DNA. They act through hydrolysis of a 5'-phosphodiester bond, resulting in DNA with a free 5' phosphate, which is essential for the repair of DNA double-strand breaks. These proteins can hydrolyze dead-end complexe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15822"
] | [
"TDP2-like"
] | [
11370
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.4.-",
"PWY-5978",
"PWY-6129",
"PWY-6689",
"PWY-7119",
"PWY-7366",
"R-BTA-5693571",
"R-GGA-5693571",
"R-HSA-5693571",
"R-MMU-5693571",
"R-RNO-5693571"
] | [
"EC:3.1.4.-",
"METACYC:PWY-5978",
"METACYC:PWY-6129",
"METACYC:PWY-6689",
"METACYC:PWY-7119",
"METACYC:PWY-7366",
"REACTOME:R-BTA-5693571",
"REACTOME:R-GGA-5693571",
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-5693571",
"REACTOME:R-RNO-5693571"
] | 11 | [
"3teb",
"4f1h",
"4f1i",
"4fpv",
"4fva",
"4gew",
"4gyz",
"4gz0",
"4gz1",
"4gz2",
"4puq",
"5ht2",
"5ink",
"5inl",
"5inm",
"5inn",
"5ino",
"5inp",
"5inq",
"5j3p",
"5j3s",
"5j3z",
"5j42",
"5tvp",
"5tvq",
"6ca4"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
72,
6227,
4933,
37,
101
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
2,
3,
2,
13,
6,
11
] | 8 | true | Family | Tyrosyl-DNA phosphodiesterase 2-like | Tyrosyl-DNA phosphodiesterase 2-like | TDP2-like | 2 |
IPR051548 | 51,548 | Glutaredoxin-like Electron Transport | Grx-like_ET | Family | 14,893 | true | false | This family of proteins includes members that are involved in electron transport systems, particularly for the ribonucleotide reductase system NrdEF, which is essential for DNA synthesis. Some proteins in this family function as glutaredoxins, a group of small redox enzymes that use glutathione as a cofactor to catalyz... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34386"
] | [
"Grx-like_ET"
] | [
14893
] | 1 | [] | [] | [] | 0 | [
"1h75",
"1r7h",
"2lqo",
"2lqq",
"3ic4",
"3zij",
"3zit",
"4f2i",
"4fiw",
"4hs1",
"4k8m",
"7c10",
"7c12",
"7c13"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
254,
13698,
552,
125,
264
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)"
] | [
4,
1
] | 2 | true | Family | Glutaredoxin-like Electron Transport | Glutaredoxin-like Electron Transport | Grx-like_ET | 5 |
IPR051549 | 51,549 | Phosphoenolpyruvate Utilizing Enzyme | PEP_Utilizing_Enz | Family | 11,034 | true | false | The PEP-utilizing enzyme family includes proteins involved in various biosynthetic processes. Members of this family are characterized by their ability to utilize phosphoenolpyruvate (PEP) in enzymatic reactions. The family encompasses enzymes such as phosphotransferases and synthases. Functions of these proteins inclu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43615"
] | [
"PEP_Utilizing_Enz"
] | [
11034
] | 1 | [] | [] | [] | 0 | [
"5fbs",
"5fbt",
"5fbu",
"5hv1",
"5hv2",
"5hv3"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
163,
9368,
1307,
2,
194
] | 5 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Family | Phosphoenolpyruvate Utilizing Enzyme | Phosphoenolpyruvate Utilizing Enzyme | PEP_Utilizing_Enz | 4 |
IPR051551 | 51,551 | Bacterial autotransporter adhesion | Autotransporter_adhesion | Family | 12,572 | true | false | This family of proteins includes autotransporters, which are involved in bacterial pathogenesis through mechanisms such as adhesion to host cells, invasion, and biofilm formation. They typically possess a signal peptide that directs the protein to the periplasmic space and a C-terminal translocator domain that inserts ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35037"
] | [
"Autotransporter_adhesion"
] | [
12572
] | 1 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"2qom",
"3qq2",
"3slj",
"3slo",
"3slt",
"5ke1",
"7akv",
"7ttc",
"8axg"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ct5lU19",
"metagenomes"
] | [
12537,
18,
1,
16
] | 4 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
4,
1
] | 2 | true | Family | Bacterial autotransporter adhesion | Bacterial autotransporter adhesion | Autotransporter_adhesion | 1 |
IPR051552 | 51,552 | Hexose Phosphate Transport Regulator | HptR | Family | 16,529 | true | false | The protein family comprises transcriptional regulatory proteins that are part of two-component regulatory systems. These systems play a crucial role in the regulation of genes associated with hexose phosphate transport in response to extracellular phosphate levels. Family members such as HptR activate the expression o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42713"
] | [
"HptR"
] | [
16529
] | 1 | [] | [] | [] | 0 | [
"3cu5",
"6swb",
"6swf"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
16493,
13,
23
] | 3 | [
"Arabidopsis thaliana"
] | [
2
] | 1 | true | Family | Hexose Phosphate Transport Regulator | Hexose Phosphate Transport Regulator | HptR | 9 |
IPR051553 | 51,553 | Ran GTPase-activating | Ran_GTPase-activating | Family | 20,848 | true | false | The protein family is involved in critical cellular processes such as chromosome condensation, mitotic spindle assembly, and nucleocytoplasmic transport. Members act as guanine-nucleotide releasing factors, facilitating the exchange of GDP for GTP on the Ran GTPase, which is pivotal for maintaining high levels of GTP-b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45982"
] | [
"Ran_GTPase-activating"
] | [
20848
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1169408",
"R-CEL-936440",
"R-CEL-9615933",
"R-CEL-983168",
"R-CEL-9833482",
"R-CEL-9909505",
"R-DDI-1169408",
"R-DDI-936440",
"R-DDI-983168",
"R-DDI-9909505",
"R-DME-9615933",
"R-HSA-165054",
"R-HSA-180746",
"R-HSA-9615933",
"R-MMU-9615933",
"R-SCE-9615933",
"R-SPO-9615933"
] | [
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-936440",
"REACTOME:R-CEL-9615933",
"REACTOME:R-CEL-983168",
"REACTOME:R-CEL-9833482",
"REACTOME:R-CEL-9909505",
"REACTOME:R-DDI-1169408",
"REACTOME:R-DDI-936440",
"REACTOME:R-DDI-983168",
"REACTOME:R-DDI-9909505",
"REACTOME:R-DME-9615933",
"REACTOME:R-... | 17 | [
"1a12",
"1i2m",
"3mvd",
"3of7",
"4d4o",
"4d4p",
"4d4q",
"4x33",
"5hq2",
"5t94",
"5tbk",
"6xzl",
"8ux1"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Viruses",
"metagenomes"
] | [
5288,
15100,
29,
237,
194
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
2,
1,
5,
12,
6,
4,
4,
6,
3,
2,
5
] | 12 | true | Family | Ran GTPase-activating | Ran GTPase-activating | Ran_GTPase-activating | 3 |
IPR051554 | 51,554 | Acetyltransferase Eis | Acetyltransferase_Eis | Family | 11,632 | true | false | The acetyltransferase Eis family comprises proteins that function as effectors released into host cells, modulating host immune responses and contributing to bacterial survival. Members of the family possess acetyltransferase activity, acetylating lysine residues of host proteins and multiple amine groups of aminoglyco... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37817"
] | [
"Acetyltransferase_Eis"
] | [
11632
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 220 | [
"2hv2",
"2i00",
"2ozg",
"3n7z",
"3r1k",
"3ryo",
"3sxn",
"3sxo",
"3uy5",
"4jd6",
"4my0",
"4my3",
"4qb9",
"5ebv",
"5ec4",
"5iv0",
"5tvj",
"6b0u",
"6b3t",
"6p3t",
"6p3u",
"6p3v",
"6rft",
"6rfx",
"6rfy",
"6vur",
"6vus",
"6vut",
"6vuu",
"6vuw",
"6vux",
"6vuy"... | 56 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
266,
11165,
94,
107
] | 4 | [] | [] | 0 | true | Family | Acetyltransferase Eis | Acetyltransferase Eis | Acetyltransferase_Eis | 2 |
IPR051555 | 51,555 | Formate Dehydrogenase Electron Transfer Unit | FDH_Electron_Transfer_Unit | Family | 8,649 | true | false | The protein family consists of electron transfer units involved in various respiratory processes. Members of the family participate in the reversible two-electron oxidation of formate to carbon dioxide, functioning as integral components of formate dehydrogenase complexes. These complexes facilitate the use of formate ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43545"
] | [
"FDH_Electron_Transfer_Unit"
] | [
8649
] | 1 | [] | [] | [] | 0 | [
"1h0h",
"1kqf",
"1kqg",
"6sdr",
"6sdv",
"7z5o",
"8bqg",
"8bqh",
"8bqi",
"8bqj",
"8bqk",
"8bql",
"8cm4",
"8cm5",
"8cm6",
"8cm7",
"8rc8",
"8rc9",
"8rca",
"8rcb",
"8rcc",
"8rcg",
"9qm0",
"9qm1"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
47,
8502,
13,
87
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Formate Dehydrogenase Electron Transfer Unit | Formate Dehydrogenase Electron Transfer Unit | FDH_Electron_Transfer_Unit | 7 |
IPR051556 | 51,556 | N-terminal and lysine N-acetyltransferase | N-term/lysine_N-AcTrnsfr | Family | 11,470 | true | false | This family of proteins includes N-alpha-acetyltransferases that modify the N-terminus of proteins by acetylating the initiating methionine, a process that is essential for various cellular functions. These proteins exhibit a broad substrate specificity and are involved in critical processes such as sister chromatid co... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42919"
] | [
"N-term/lysine_N-AcTrnsfr"
] | [
11470
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"2.3.1.-",
"2.3.1.258",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710... | [
"EC:2.3.1.-",
"EC:2.3.1.258",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",... | 221 | [
"1tiq",
"1vkc",
"1wwz",
"2ob0",
"2psw",
"3tfy",
"4e2a",
"4pv6",
"4x5k",
"4xnh",
"4xpd",
"4y49",
"6hd5",
"6hd7",
"6o07",
"6ppl",
"6pw9",
"6wf3",
"6wf5",
"6wfg",
"6wfk",
"6wfn",
"6wfo",
"6yzz",
"6z00",
"7oju",
"8osp",
"9f1b",
"9f1c",
"9f1d",
"9mto"
] | 31 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
191,
5332,
5857,
8,
82
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
2,
4,
1,
7,
1,
1,
6,
6,
1,
1,
8
] | 12 | true | Family | N-terminal and lysine N-acetyltransferase | N-terminal and lysine N-acetyltransferase | N-term/lysine_N-AcTrnsfr | 3 |
IPR051557 | 51,557 | NipSnap domain-containing protein | NipSnap_domain | Family | 8,990 | true | false | This family of proteins is characterized by a common structural motif known as the NipSnap domain. Members of this family are implicated in various cellular processes, although their precise biological functions may vary among different organisms and homologs. Some proteins within this family have been suggested to act... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21017"
] | [
"NipSnap_domain"
] | [
8990
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9013407",
"R-DDI-9013407",
"R-DME-9013407",
"R-HSA-9013407",
"R-HSA-9013409",
"R-MMU-9013407"
] | [
"REACTOME:R-CEL-9013407",
"REACTOME:R-DDI-9013407",
"REACTOME:R-DME-9013407",
"REACTOME:R-HSA-9013407",
"REACTOME:R-HSA-9013409",
"REACTOME:R-MMU-9013407"
] | 6 | [
"1vqs",
"1vqy",
"2ap6",
"5ixu",
"5k9f",
"5kak"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences",
"uncultured marine group II/III euryarchaeote AD1000_35_F01"
] | [
2419,
6510,
1,
59,
1
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
5,
2,
15,
13,
1,
20
] | 7 | true | Family | NipSnap domain-containing protein | NipSnap domain-containing protein | NipSnap_domain | 6 |
IPR051558 | 51,558 | Metallophosphoesterase Purple Acid Phosphatase | Metallophosphoesterase_PAP | Family | 9,553 | true | false | This family of proteins includes metallophosphoesterases known as purple acid phosphatases (PAPs). Members of this family are involved in various biological processes, including phosphate metabolism and bone resorption. They exhibit phosphatase activity towards a range of substrates, such as nucleotide tri- and diphosp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10161"
] | [
"Metallophosphoesterase_PAP"
] | [
9553
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.2",
"PWY-6348",
"R-HSA-196843",
"R-MMU-196843",
"R-RNO-196843",
"R-SSC-196843"
] | [
"EC:3.1.3.2",
"METACYC:PWY-6348",
"REACTOME:R-HSA-196843",
"REACTOME:R-MMU-196843",
"REACTOME:R-RNO-196843",
"REACTOME:R-SSC-196843"
] | 6 | [
"1qfc",
"1qhw",
"1ute",
"1war",
"2bq8",
"3tgh",
"5uq6",
"7ov2",
"7ov3",
"7ov8"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
2873,
6628,
7,
45
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
30,
1,
5,
7,
2,
9,
6,
44
] | 8 | true | Family | Metallophosphoesterase Purple Acid Phosphatase | Metallophosphoesterase Purple Acid Phosphatase | Metallophosphoesterase_PAP | 6 |
IPR051560 | 51,560 | MAM domain-containing protein | MAM_domain-containing | Family | 10,328 | true | false | This family of proteins includes members that are involved in various cellular processes, such as sorting and selective transport of receptors and ligands across polarized epithelia, regulation of bile acid synthesis through production and/or transport of fibroblast growth factors, and potential roles in cell-cell inte... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23282"
] | [
"MAM_domain-containing"
] | [
10328
] | 1 | [] | [] | [] | 0 | [
"5l73",
"8yt7",
"8ziy"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured virus"
] | [
612,
9710,
4,
2
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
65,
91,
11,
13,
10
] | 5 | true | Family | MAM domain-containing protein | MAM domain-containing protein | MAM_domain-containing | 6 |
IPR051561 | 51,561 | FRAS1-related extracellular matrix | FRAS1_ECM | Family | 9,131 | true | false | The FRAS1 family proteins are extracellular matrix proteins that play crucial roles in tissue integrity, cell adhesion, and embryonic development. They are involved in the maintenance of the skin and renal epithelia, epidermal differentiation, and adhesion. These proteins are essential for the proper development of eye... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45739"
] | [
"FRAS1_ECM"
] | [
9131
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1971475",
"R-HSA-2022870",
"R-HSA-2022923",
"R-HSA-2024101",
"R-HSA-3560783",
"R-HSA-3560801",
"R-HSA-3595172",
"R-HSA-3595174",
"R-HSA-3595177",
"R-HSA-4420332",
"R-HSA-9725554",
"R-MMU-1971475",
"R-MMU-2022870",
"R-MMU-2022923",
"R-MMU-2024101",
"R-RNO-1971475",
"R-RNO-20228... | [
"REACTOME:R-HSA-1971475",
"REACTOME:R-HSA-2022870",
"REACTOME:R-HSA-2022923",
"REACTOME:R-HSA-2024101",
"REACTOME:R-HSA-3560783",
"REACTOME:R-HSA-3560801",
"REACTOME:R-HSA-3595172",
"REACTOME:R-HSA-3595174",
"REACTOME:R-HSA-3595177",
"REACTOME:R-HSA-4420332",
"REACTOME:R-HSA-9725554",
"REACTOM... | 19 | [
"7n8x",
"7n9y"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Agrobacterium phage Atu_ph07",
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1,
4,
544,
8574,
8
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
28,
3,
13,
13,
24
] | 6 | true | Family | FRAS1-related extracellular matrix | FRAS1-related extracellular matrix | FRAS1_ECM | 7 |
IPR051562 | 51,562 | Ascorbate-specific PTS system EIIC component | Ascorbate-PTS_EIIC | Family | 7,952 | true | false | This family of proteins is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which is a major carbohydrate active transport system. These proteins catalyze the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Specifically, t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33843"
] | [
"Ascorbate-PTS_EIIC"
] | [
7952
] | 1 | [] | [] | [] | 0 | [
"4rp8",
"4rp9",
"5zov"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
9,
7920,
10,
13
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ascorbate-specific PTS system EIIC component | Ascorbate-specific PTS system EIIC component | Ascorbate-PTS_EIIC | 9 |
IPR051563 | 51,563 | Glycosyl Hydrolase Family 51 | Glycosyl_Hydrolase_51 | Family | 7,870 | true | false | The glycosyl hydrolase 51 family is involved in the degradation of plant cell wall components, particularly arabinoxylan, which is a major constituent of hemicellulose. Members of this family act on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides, facilitating the breakdown of complex carbohydrates in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31776"
] | [
"Glycosyl_Hydrolase_51"
] | [
7870
] | 1 | [
"EC"
] | [
"3.2.1.55"
] | [
"EC:3.2.1.55"
] | 1 | [
"6zps",
"6zpv",
"6zpw",
"6zpx",
"6zpy",
"6zpz",
"6zq0",
"6zq1"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3474,
4364,
32
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
1,
35,
79
] | 4 | true | Family | Glycosyl Hydrolase Family 51 | Glycosyl Hydrolase Family 51 | Glycosyl_Hydrolase_51 | 9 |
IPR051564 | 51,564 | Leucine-rich repeat receptor-like kinase | LRR_receptor-like_kinase | Family | 5,465 | true | false | The LRR receptor-like kinase family encompasses proteins with roles in plant growth regulation, immunity, and development. Members act as receptors for various ligands, including defense peptides, CLV3-like peptides, and phytosulfokines, triggering signaling cascades essential for plant cell differentiation, organogene... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48055"
] | [
"LRR_receptor-like_kinase"
] | [
5465
] | 1 | [] | [] | [] | 0 | [
"4oh4",
"4q5j",
"5lpb",
"5lpv",
"5lpw",
"5lpy",
"5lpz",
"7ctv",
"7ctx",
"8jup",
"8juv"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"human gut metagenome"
] | [
3,
5461,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
46,
38
] | 3 | true | Family | Leucine-rich repeat receptor-like kinase | Leucine-rich repeat receptor-like kinase | LRR_receptor-like_kinase | 1 |
IPR051565 | 51,565 | Sal C2H2-type zinc-finger | Sal_C2H2-zinc-finger | Family | 8,163 | true | false | The sal C2H2-type zinc-finger protein family comprises transcription factors involved in a variety of developmental processes across different species. Members of the family play crucial roles in organogenesis, such as kidney development and eye formation, and are essential for the maintenance and self-renewal of embry... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23233"
] | [
"Sal_C2H2-zinc-finger"
] | [
8163
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-8943724",
"R-HSA-2892247",
"R-HSA-452723",
"R-HSA-8943724",
"R-HSA-9830674",
"R-MMU-8943724"
] | [
"REACTOME:R-DME-8943724",
"REACTOME:R-HSA-2892247",
"REACTOME:R-HSA-452723",
"REACTOME:R-HSA-8943724",
"REACTOME:R-HSA-9830674",
"REACTOME:R-MMU-8943724"
] | 6 | [
"6uml",
"7y3i",
"7y3k",
"7y3l",
"7y3m",
"8a4i",
"8cuc",
"8u15",
"8u16",
"8u17"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8163
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
49,
6,
26,
13,
1,
14
] | 7 | true | Family | Sal C2H2-type zinc-finger | Sal C2H2-type zinc-finger | Sal_C2H2-zinc-finger | 2 |
IPR051566 | 51,566 | Connector enhancer of kinase suppressor of Ras | CNKSR | Family | 8,267 | true | false | The CNKSR family proteins function as adapter or scaffold proteins involved in various signaling pathways. They enhance guanine-nucleotide exchange on ARF6, regulate Ras signaling, and are implicated in cell migration and transepithelial sodium transport. The family members coordinate the assembly of protein complexes,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12844"
] | [
"CNKSR"
] | [
8267
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5674135",
"R-HSA-5674135",
"R-HSA-6802946",
"R-HSA-6802948",
"R-HSA-6802952",
"R-HSA-6802955",
"R-HSA-9649948",
"R-HSA-9656223",
"R-MMU-5674135",
"R-RNO-5674135"
] | [
"REACTOME:R-CEL-5674135",
"REACTOME:R-HSA-5674135",
"REACTOME:R-HSA-6802946",
"REACTOME:R-HSA-6802948",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-6802955",
"REACTOME:R-HSA-9649948",
"REACTOME:R-HSA-9656223",
"REACTOME:R-MMU-5674135",
"REACTOME:R-RNO-5674135"
] | 10 | [
"1wwv",
"2ean",
"3bs5",
"5mr1",
"8bw8",
"8bw9",
"9k1l"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8267
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
66,
1,
37,
15,
27
] | 6 | true | Family | Connector enhancer of kinase suppressor of Ras | Connector enhancer of kinase suppressor of Ras | CNKSR | 6 |
IPR051567 | 51,567 | Unconventional Myosin ATPase | Unconventional_Myosin_ATPase | Family | 8,922 | true | false | The Unconventional Myosin family comprises motor proteins with ATPase activity that interact with actin filaments for intracellular movements. Members of the family have highly divergent tails, which are thought to bind to membranous compartments, facilitating their movement relative to the actin cytoskeleton. These my... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22692"
] | [
"Unconventional_Myosin_ATPase"
] | [
8922
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2453902",
"R-DME-2453902",
"R-HSA-2453902",
"R-HSA-9662360",
"R-HSA-9662361",
"R-MMU-2453902"
] | [
"REACTOME:R-CEL-2453902",
"REACTOME:R-DME-2453902",
"REACTOME:R-HSA-2453902",
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361",
"REACTOME:R-MMU-2453902"
] | 6 | [
"2dlp",
"3pvl",
"5ejr",
"5ejs",
"5f3y",
"5mv7",
"5mv8",
"5mv9",
"5xbf",
"7r91",
"7rb8",
"7rb9",
"7udt",
"7udu"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8922
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
9,
34,
9,
37,
17,
20,
4
] | 7 | true | Family | Unconventional Myosin ATPase | Unconventional Myosin ATPase | Unconventional_Myosin_ATPase | 8 |
IPR051568 | 51,568 | LZTR1/Attractin | LZTR1/Attractin | Family | 8,152 | true | true | The LZTR1/Attractin family includes proteins that are involved in various cellular processes. LZTR1 proteins act as substrate-specific adapters for BCR E3 ubiquitin-protein ligase complexes, targeting Ras proteins for ubiquitination and thereby negatively regulating RAS-MAPK signalling [ , , ]. This function is crucial... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46376"
] | [
"LZTR1/Attractin"
] | [
8152
] | 1 | [] | [] | [] | 0 | [
"9mey",
"9mez",
"9mf0"
] | 3 | [
"PUB00082152",
"PUB00155414",
"PUB00155415",
"PUB00155416",
"PUB00155417"
] | [
"9736737",
"17261078",
"30442762",
"30442766",
"30481304"
] | [
"Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.",
"Does human attractin have DP4 activity?",
"Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.",
"LZTR1 is a r... | [
1998,
2007,
2018,
2018,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
90,
8056,
6
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
14,
7,
20,
11,
16
] | 6 | true | Family | LZTR1/Attractin | LZTR1/Attractin | LZTR1/Attractin | 9 |
IPR051570 | 51,570 | TBC1 domain family involved in cilium biogenesis | TBC1_cilium_biogenesis | Family | 7,781 | true | false | The TBC1 domain family is involved in cilium biogenesis and functions as a molecular adapter. It is part of a complex that includes the centriolar protein OFD1, which is essential for cilium assembly. Members of the family may regulate the cAMP-dependent phosphorylation of OFD1, leading to its ubiquitination by PJA2 an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19853"
] | [
"TBC1_cilium_biogenesis"
] | [
7781
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 6 | [
"5ic9",
"5ica",
"5oql",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t"... | 52 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
7779
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
3,
3,
16,
5,
1,
5,
11,
1,
1,
8
] | 12 | true | Family | TBC1 domain family involved in cilium biogenesis | TBC1 domain family involved in cilium biogenesis | TBC1_cilium_biogenesis | 3 |
IPR051571 | 51,571 | Nuclear receptor corepressor | N-CoR_corepressor | Family | 8,271 | true | false | This family of proteins functions as transcriptional corepressors for nuclear receptors. They are involved in chromatin condensation, which restricts access of basal transcription machinery to DNA, thereby repressing gene expression. Members of this family contain conserved CORNR box motifs that are essential for bindi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13992"
] | [
"N-CoR_corepressor"
] | [
8271
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-381340",
"R-CEL-383280",
"R-HSA-1251985",
"R-HSA-1989781",
"R-HSA-2122947",
"R-HSA-2151201",
"R-HSA-2173795",
"R-HSA-2644606",
"R-HSA-2894862",
"R-HSA-3214815",
"R-HSA-350054",
"R-HSA-381340",
"R-HSA-383280",
"R-HSA-3899300",
"R-HSA-400206",
"R-HSA-5617472",
"R-HSA-9022537",
... | [
"REACTOME:R-CEL-381340",
"REACTOME:R-CEL-383280",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-2173795",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2894862",
"REACTOME:R-HSA-3214815",
"REACTOME:R-HSA-350054",
"REACTOME:R... | 44 | [
"1xc5",
"2eqr",
"2l5g",
"2ltp",
"4a69"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
8265
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
84,
8,
37,
30,
3,
18,
1,
1
] | 9 | true | Family | Nuclear receptor corepressor | Nuclear receptor corepressor | N-CoR_corepressor | 5 |
IPR051572 | 51,572 | Vacuolar Transporter Chaperone Complex Subunit | VTC_Complex_Subunit | Family | 7,760 | true | false | This family of proteins functions as subunits of the vacuolar transporter chaperone (VTC) complex, which is involved in the synthesis and translocation of inorganic polyphosphate (polyP). The complex catalyzes the transfer of phosphate from ATP to a growing polyP chain, releasing ADP, and integrates cytoplasmic polymer... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46140"
] | [
"VTC_Complex_Subunit"
] | [
7760
] | 1 | [] | [] | [] | 0 | [
"3g3o",
"3g3q",
"3g3r",
"3g3t",
"3g3u",
"5iig",
"5iiq",
"5iit",
"5ijp",
"5lnc",
"7ytj",
"8i6v"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Promethearchaeaceae",
"Terrestrivirus sp.",
"ecological metagenomes"
] | [
14,
7740,
2,
1,
3
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
5,
3
] | 3 | true | Family | Vacuolar Transporter Chaperone Complex Subunit | Vacuolar Transporter Chaperone Complex Subunit | VTC_Complex_Subunit | 3 |
IPR051573 | 51,573 | Ankyrin repeat and SOCS box protein-like | Ankyrin-SOCS_box_domain | Family | 7,885 | true | true | This family of proteins includes components that may act as substrate-recognition modules within SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complexes. These complexes are involved in the ubiquitination and subsequent proteasomal degradation of target proteins, which is a critical process... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24136"
] | [
"Ankyrin-SOCS_box_domain"
] | [
7885
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-BTA-983168",
"R-DRE-8951664",
"R-DRE-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-DRE-8951664",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168"
] | 8 | [
"3d9h",
"3zkj",
"3zng",
"4uuc",
"6v9h"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"metagenomes"
] | [
142,
7720,
16,
7
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
20,
14,
13,
48,
25,
7
] | 7 | true | Family | Ankyrin repeat and SOCS box protein-like | Ankyrin repeat and SOCS box protein-like | Ankyrin-SOCS_box_domain | 8 |
IPR051574 | 51,574 | Zinc finger E-box-binding homeobox | ZnF_E-box_Homeobox | Family | 7,604 | true | false | The Zinc finger E-box-binding homeobox family comprises transcription factors that play critical roles in gene expression regulation. Members of this family typically function as transcriptional repressors, binding to E-box sequences in gene promoters to modulate transcription. They are involved in various biological p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24391"
] | [
"ZnF_E-box_Homeobox"
] | [
7604
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9764725",
"R-DME-9762293",
"R-DME-9764725",
"R-HSA-6785807",
"R-HSA-9762293",
"R-HSA-9764725",
"R-HSA-9764790",
"R-HSA-9823739",
"R-HSA-9832991",
"R-HSA-9926550",
"R-MMU-9762293",
"R-MMU-9764725",
"R-RNO-9764725"
] | [
"REACTOME:R-CEL-9764725",
"REACTOME:R-DME-9762293",
"REACTOME:R-DME-9764725",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9762293",
"REACTOME:R-HSA-9764725",
"REACTOME:R-HSA-9764790",
"REACTOME:R-HSA-9823739",
"REACTOME:R-HSA-9832991",
"REACTOME:R-HSA-9926550",
"REACTOME:R-MMU-9762293",
"REACTOM... | 13 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7604
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
48,
7,
29,
18,
18
] | 6 | true | Family | Zinc finger E-box-binding homeobox | Zinc finger E-box-binding homeobox | ZnF_E-box_Homeobox | 5 |
IPR051575 | 51,575 | Myb-like DNA-binding | Myb-like_DNA-bd | Family | 8,446 | true | false | The Myb-like DNA-binding protein family is characterized by its role in transcriptional regulation across various organisms. Members of this family are involved in activating transcription of genes associated with specific biological processes, such as histidine biosynthesis, purine biosynthesis, fruiting body formatio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46621"
] | [
"Myb-like_DNA-bd"
] | [
8446
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6807505",
"R-DDI-6807505",
"R-HSA-6807505",
"R-HSA-749476",
"R-HSA-76071",
"R-MMU-6807505",
"R-MMU-76071"
] | [
"REACTOME:R-CEL-6807505",
"REACTOME:R-DDI-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76071",
"REACTOME:R-MMU-6807505",
"REACTOME:R-MMU-76071"
] | 7 | [
"1guu",
"1mbe",
"1mbf",
"2d9a",
"2k9n",
"2kdz",
"3osf",
"3osg",
"7xur",
"7zwc",
"7zwd",
"7zx7",
"7zx8",
"7zxe",
"8ity",
"8iue",
"8iuh",
"9fso",
"9fsp",
"9fsq",
"9fsr",
"9fss",
"9k3b",
"9k3u",
"9k3v",
"9lxn"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Blautia",
"Eukaryota"
] | [
2,
8444
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
16,
1,
4,
1,
5,
4,
2,
8,
4,
1,
7
] | 11 | true | Family | Myb-like DNA-binding | Myb-like DNA-binding | Myb-like_DNA-bd | 1 |
IPR051576 | 51,576 | PX Domain-Containing Rho GAP | PX-Rho_GAP | Family | 6,702 | true | false | The PX domain-containing GAP family is characterized by its involvement in the regulation of small GTPases such as RHOA, CDC42, and RAC1. Members of this family function as GTPase-activating proteins (GAPs), promoting GTP hydrolysis and thus regulating the activity of their target GTPases. These proteins play critical ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15729"
] | [
"PX-Rho_GAP"
] | [
6702
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-8980692",
"R-DME-9013026",
"R-DME-9013148",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013405",
"R-DME-9013406",
"R-DME-9013408",
"R-DME-9013409",
"R-DME-9013420",
"R-DME-9013423",
"R-DME-9035034",
"R-DME-9768727",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-HSA-90131... | [
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R-DME-9013148",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013404",
"REACTOME:R-DME-9013405",
"REACTOME:R-DME-9013406",
"REACTOME:R-DME-9013408",
"REACTOME:R-DME-9013409",
"REACTOME:R-DME-9013420",
"REACTOME:R-DME-9013423",
"REACTOM... | 41 | [
"3iug"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
6702
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
42,
4,
26,
14,
20
] | 6 | true | Family | PX Domain-Containing Rho GAP | PX Domain-Containing Rho GAP | PX-Rho_GAP | 1 |
IPR051577 | 51,577 | Myelin Regulatory Factor-like | MRF-like | Family | 4,344 | true | false | This family of proteins includes transcription factors that are key regulators in the maturation and maintenance of the nervous system, particularly in the formation of myelin, which is essential for proper nerve conduction. Members of this family are involved in the activation of gene expression related to myelin prod... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13029"
] | [
"MRF-like"
] | [
4344
] | 1 | [] | [] | [] | 0 | [
"5h5p",
"5yhu",
"5zhu",
"7dc3"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
173,
4130,
23,
18
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
15,
4,
10,
3,
9
] | 6 | true | Family | Myelin Regulatory Factor-like | Myelin Regulatory Factor-like | MRF-like | 4 |
IPR051578 | 51,578 | Glycerophosphodiester Phosphodiesterase | GDPD | Family | 6,669 | true | false | This family of proteins includes enzymes with glycerophosphodiester phosphodiesterase activity, which are involved in the metabolism of glycerophospholipids. They hydrolyze glycerophosphocholine to glycerol-phosphate and choline, a process important for the synthesis of phosphatidylcholine and the utilization of glycer... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22958"
] | [
"GDPD"
] | [
6669
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.1.4",
"R-HSA-1483115",
"R-HSA-1483152"
] | [
"EC:3.1.4",
"REACTOME:R-HSA-1483115",
"REACTOME:R-HSA-1483152"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
14,
6655
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
2,
13,
14,
3,
2,
1,
9,
6,
1,
1,
29
] | 12 | true | Family | Glycerophosphodiester Phosphodiesterase | Glycerophosphodiester Phosphodiesterase | GDPD | 5 |
IPR051579 | 51,579 | DNA Damage Response and Transcriptional Regulator | DDR_Transcriptional_Reg | Family | 6,348 | true | false | The protein family is involved in the DNA damage response (DDR) and transcriptional regulation. Members of the family function as mediators and scaffolds at sites of DNA damage, recognizing and binding to specific phosphorylated histone markers, such as H2AX phosphorylated at 'Ser-139'. They facilitate the recruitment ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23196"
] | [
"DDR_Transcriptional_Reg"
] | [
6348
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5693571",
"R-BTA-9772755",
"R-BTA-9818564",
"R-DRE-9772755",
"R-DRE-9818564",
"R-HSA-3108214",
"R-HSA-5617472",
"R-HSA-5693565",
"R-HSA-5693571",
"R-HSA-5693607",
"R-HSA-6796648",
"R-HSA-69473",
"R-HSA-9772755",
"R-HSA-9818564",
"R-HSA-9841922",
"R-MMU-3108214",
"R-MMU-5693565... | [
"REACTOME:R-BTA-5693571",
"REACTOME:R-BTA-9772755",
"REACTOME:R-BTA-9818564",
"REACTOME:R-DRE-9772755",
"REACTOME:R-DRE-9818564",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5617472",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-6796648",
"REACTOM... | 27 | [
"2ado",
"2azm",
"2etx",
"3k05",
"3sqd",
"7p0j",
"7p0l"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactobacillaceae",
"bird metagenome"
] | [
6345,
2,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
20,
2,
4,
5,
20,
3,
8,
10,
1,
31
] | 10 | true | Family | DNA Damage Response and Transcriptional Regulator | DNA Damage Response and Transcriptional Regulator | DDR_Transcriptional_Reg | 7 |
IPR051580 | 51,580 | Zinc finger and chromatin remodeling-associated protein | ZnF-Chromatin_assoc | Family | 5,132 | true | false | This family of proteins includes transcription factors and components of multiprotein complexes involved in chromatin remodeling and transcriptional regulation. They play roles in various biological processes including ribosome biogenesis, cell cycle progression, myeloid and lymphoid cell development, and neural develo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23057"
] | [
"ZnF-Chromatin_assoc"
] | [
5132
] | 1 | [] | [] | [] | 0 | [
"3iuf"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5132
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
8,
3,
8,
6,
1,
7,
1,
1
] | 9 | true | Family | Zinc finger and chromatin remodeling-associated protein | Zinc finger and chromatin remodeling-associated protein | ZnF-Chromatin_assoc | 7 |
IPR051581 | 51,581 | Calcium-Binding Signalling family | Ca-bind | Family | 6,482 | true | true | Calcium binding signalling proteins are characterised by their ability to bind calcium, which suggests a role in cellular signalling events. While some members are hypothesised to function as regulatory proteins rather than as calcium buffers or transport proteins, the exact mechanisms by which they influence signallin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34524"
] | [
"Ca-bind_SignalingProt"
] | [
6482
] | 1 | [] | [] | [] | 0 | [
"3e3r",
"3mse",
"4n5x",
"4zcu",
"4zcv",
"7jtk",
"7ju4",
"8g2z",
"8g3d",
"8glv",
"8sf7",
"8v3l",
"9e2g",
"9e5c",
"9e78"
] | 15 | [
"PUB00160501"
] | [
"22375103"
] | [
"Evolution and functional diversity of the Calcium Binding Proteins (CaBPs)."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"uncultured archaeon MedDCM-OCT-S04-C14"
] | [
23,
6458,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
3,
13,
5,
10
] | 5 | true | Family | Calcium-Binding Signalling family | Calcium-Binding Signalling family | Ca-bind | 8 |
IPR051582 | 51,582 | Leucine-rich repeat extensin-like regulator | LRR_extensin-like_regulator | Family | 7,222 | true | false | This family of proteins is involved in the modulation of cell morphogenesis. They play a crucial role in the regulation of cell wall formation, assembly, and growth polarization. Some members of this family are specifically expressed in pollen, while others are implicated in root hair morphogenesis and elongation. Thes... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32093"
] | [
"LRR_extensin-like_regulator"
] | [
7222
] | 1 | [] | [] | [] | 0 | [
"6qwn",
"6qxp",
"6tme"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
7218
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
76,
51,
143
] | 3 | true | Family | Leucine-rich repeat extensin-like regulator | Leucine-rich repeat extensin-like regulator | LRR_extensin-like_regulator | 9 |
IPR051583 | 51,583 | Yes-associated protein 1 | YAP1 | Family | 4,867 | true | false | The YAP1 family comprises transcriptional regulators that function as coactivators or corepressors. They are essential components of the Hippo signaling pathway, which is crucial for controlling organ size, suppressing tumors, and regulating apoptosis and proliferation. Family members mediate tissue tension and 3D tiss... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17616"
] | [
"YAP1"
] | [
4867
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1251985",
"R-CEL-2028269",
"R-CEL-2032785",
"R-CEL-2173796",
"R-CEL-8939236",
"R-CEL-8951671",
"R-CEL-9860927",
"R-CFA-1251985",
"R-CFA-2028269",
"R-CFA-2032785",
"R-CFA-2173796",
"R-CFA-8939236",
"R-CFA-8951671",
"R-CFA-9860927",
"R-DME-390098",
"R-DME-390193",
"R-DME-451806"... | [
"REACTOME:R-CEL-1251985",
"REACTOME:R-CEL-2028269",
"REACTOME:R-CEL-2032785",
"REACTOME:R-CEL-2173796",
"REACTOME:R-CEL-8939236",
"REACTOME:R-CEL-8951671",
"REACTOME:R-CEL-9860927",
"REACTOME:R-CFA-1251985",
"REACTOME:R-CFA-2028269",
"REACTOME:R-CFA-2032785",
"REACTOME:R-CFA-2173796",
"REACTOM... | 49 | [
"1i5h",
"1jmq",
"1k5r",
"1k9q",
"1k9r",
"1tk7",
"1wmv",
"1wr7",
"1yiu",
"2djy",
"2dmv",
"2ez5",
"2jmf",
"2jo9",
"2joc",
"2kpz",
"2kq0",
"2kxq",
"2kyk",
"2l4j",
"2laj",
"2law",
"2lax",
"2lay",
"2lb1",
"2lb2",
"2ltv",
"2ltw",
"2ltx",
"2ltz",
"2m3o",
"2mpt"... | 67 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Undibacterium luofuense",
"viral metagenome"
] | [
4864,
1,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
5,
17,
9,
12
] | 6 | true | Family | Yes-associated protein 1 | Yes-associated protein 1 | YAP1 | 4 |
IPR051584 | 51,584 | GPCR-associated LMBR1 domain-containing protein | GPCR-associated_LMBR1 | Family | 5,695 | true | false | This family of proteins is associated with G-protein coupled receptors (GPCRs) and is implicated in the regulation of downstream signaling pathways. Members of this family are known to interact with specific GPCRs, such as the beta-2 adrenergic receptor and the type-1 angiotensin II receptor, and can negatively regulat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21355"
] | [
"GPCR-associated_LMBR1"
] | [
5695
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Klosneuvirinae"
] | [
5693,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
3,
1,
5,
2,
2,
1,
1,
5,
2,
1,
42
] | 11 | true | Family | GPCR-associated LMBR1 domain-containing protein | GPCR-associated LMBR1 domain-containing protein | GPCR-associated_LMBR1 | 7 |
IPR051585 | 51,585 | STE20 Subfamily Serine/Threonine Kinases | STE20_Ser/Thr_Kinases | Family | 5,208 | true | false | This family of proteins includes serine/threonine kinases that are part of the STE20 subfamily within the protein kinase superfamily. Members are involved in various cellular processes, including the regulation of lymphocyte migration through phosphorylation of cytoskeletal proteins such as MSN and ERM proteins. Some a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46538"
] | [
"STE20_Ser/Thr_Kinases"
] | [
5208
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-DRE-6798695",
"R-DRE-8980692",
"R-GGA-6798695",
"R-GGA-8980692",
"R-GGA-9013026",
"R-GGA-9013106",
"R-HSA-6798695",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-MMU-6798695",
"R-MMU-8980692",
"R-MMU-9013026",
"R-MMU-9013106",
"R-RNO-6798695",
"R-RNO-8980692",
... | [
"EC:2.7.11.1",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-8980692",
"REACTOME:R-GGA-6798695",
"REACTOME:R-GGA-8980692",
"REACTOME:R-GGA-9013026",
"REACTOME:R-GGA-9013106",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-679... | 18 | [
"2j51",
"2j7t",
"2jfl",
"2jfm",
"2uv2",
"4aot",
"4bc6",
"4equ",
"4usd",
"4use",
"4usf",
"5ajq",
"5owq",
"5owr",
"6eim",
"6gtt",
"6hvd",
"6hxf",
"6i2y",
"7qgp",
"8bem"
] | 21 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
5200
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
9,
5,
7,
13
] | 6 | true | Family | STE20 Subfamily Serine/Threonine Kinases | STE20 Subfamily Serine/Threonine Kinases | STE20_Ser/Thr_Kinases | 1 |
IPR051586 | 51,586 | Protein kinase C-binding NELL | PKC-binding_NELL | Family | 5,577 | true | false | The NELL protein family is involved in a range of biological processes primarily related to neural and bone tissue functions. Members of the family play crucial roles in cell growth, differentiation, and survival, with specific emphasis on promoting osteoblast differentiation and mineralization, as well as regulating n... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24042"
] | [
"PKC-binding_NELL"
] | [
5577
] | 1 | [
"REACTOME"
] | [
"R-HSA-428542"
] | [
"REACTOME:R-HSA-428542"
] | 1 | [
"2bo2",
"2bou",
"2box",
"6pog",
"6pol",
"7do4"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
12,
5565
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
27,
11,
12
] | 5 | true | Family | Protein kinase C-binding NELL | Protein kinase C-binding NELL | PKC-binding_NELL | 4 |
IPR051587 | 51,587 | Adhesion G-protein coupled receptor | Adhesion_GPCR | Family | 4,455 | true | false | This family of proteins includes receptors that are known to play a critical role in lung surfactant homeostasis and may also influence adipocyte function. Several members of this family are described as orphan receptors, indicating that their endogenous ligands or functions have not yet been identified. All proteins i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45813"
] | [
"Adhesion_GPCR"
] | [
4455
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5683826",
"R-MMU-5683826",
"R-RNO-5683826"
] | [
"REACTOME:R-HSA-5683826",
"REACTOME:R-MMU-5683826",
"REACTOME:R-RNO-5683826"
] | 3 | [
"4dlo",
"7wu3",
"7wu4",
"7wu5",
"7wxu",
"7wxw",
"7wy0",
"7wz7",
"7x2v",
"8g2y",
"8hc0"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4455
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
2,
20,
15,
19
] | 5 | true | Family | Adhesion G-protein coupled receptor | Adhesion G-protein coupled receptor | Adhesion_GPCR | 8 |
IPR051588 | 51,588 | Eukaryotic Cobalamin Transport | Cobalamin_Transport | Family | 3,966 | true | false | This family of proteins is involved in the binding and transport of cobalamin, also known as vitamin B12. Members of this family are responsible for the protection of cobalamin from the acidic environment of the stomach and its delivery to cells. They exhibit high-affinity binding to cobalamin and are essential for its... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10559"
] | [
"Cobalamin_Transport"
] | [
3966
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9758890",
"R-CFA-9758881",
"R-DME-6798695",
"R-DME-9758881",
"R-DME-9758890",
"R-HSA-3359454",
"R-HSA-3359457",
"R-HSA-3359462",
"R-HSA-3359463",
"R-HSA-3359485",
"R-HSA-6798695",
"R-HSA-9758881",
"R-HSA-9758890",
"R-MMU-9758881",
"R-MMU-9758890",
"R-RNO-9758881",
"R-RNO-97588... | [
"REACTOME:R-BTA-9758890",
"REACTOME:R-CFA-9758881",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-9758881",
"REACTOME:R-DME-9758890",
"REACTOME:R-HSA-3359454",
"REACTOME:R-HSA-3359457",
"REACTOME:R-HSA-3359462",
"REACTOME:R-HSA-3359463",
"REACTOME:R-HSA-3359485",
"REACTOME:R-HSA-6798695",
"REACTOM... | 17 | [
"2bb5",
"2bb6",
"2bbc",
"2pmv",
"2v3n",
"2v3p",
"3kq4",
"4kki",
"4kkj",
"4zrp",
"4zrq",
"5no0",
"5np4",
"5nrp",
"5nsa",
"7qbd",
"7qbe",
"7qbf",
"7qbg",
"8ixt",
"8ixu"
] | 21 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
18,
551,
3394,
3
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
16,
2,
9
] | 5 | true | Family | Eukaryotic Cobalamin Transport | Eukaryotic Cobalamin Transport | Cobalamin_Transport | 1 |
IPR051589 | 51,589 | Sialate:O-sulfotransferase | Sialate-O-sulfotransferase | Family | 5,473 | true | false | This family of proteins includes enzymes that function as sialate:O-sulfotransferases. These enzymes are responsible for catalyzing the 8-O-sulfation of Sia-glycans using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfate donor. The resulting 8-O-sulfated Sia (Sia8S)-glycans have implications in various biologic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45964"
] | [
"Sialate-O-sulfotransferase"
] | [
5473
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
21,
5451,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
8,
6,
5,
2,
1,
5
] | 6 | true | Family | Sialate:O-sulfotransferase | Sialate:O-sulfotransferase | Sialate-O-sulfotransferase | 6 |
IPR051590 | 51,590 | DNA Replication Regulatory Kinase Subunit | Replication_Regulatory_Kinase | Family | 4,088 | true | false | This family of proteins includes regulatory subunits for kinases involved in DNA replication and cell cycle progression. Members of this family activate kinase activity essential for the initiation and regulation of DNA replication. They are involved in phosphorylating components of the pre-replication complex, particu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15375"
] | [
"Replication_Regulatory_Kinase"
] | [
4088
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-176187",
"R-DME-68962",
"R-HSA-176187",
"R-HSA-68962",
"R-MMU-176187",
"R-MMU-68962",
"R-SCE-176187",
"R-SCE-68962",
"R-SPO-176187",
"R-SPO-68962",
"R-XTR-68962"
] | [
"REACTOME:R-DME-176187",
"REACTOME:R-DME-68962",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-68962",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-68962",
"REACTOME:R-SCE-176187",
"REACTOME:R-SCE-68962",
"REACTOME:R-SPO-176187",
"REACTOME:R-SPO-68962",
"REACTOME:R-XTR-68962"
] | 11 | [
"7p5z",
"7pt6",
"7pt7",
"7v3v"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Massilia",
"Methanobrevibacter arboriphilus",
"Viruses"
] | [
4082,
3,
1,
2
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
6,
4,
1,
2,
1,
2
] | 8 | true | Family | DNA Replication Regulatory Kinase Subunit | DNA Replication Regulatory Kinase Subunit | Replication_Regulatory_Kinase | 8 |
IPR051591 | 51,591 | UPF0224 (FAM112) RNA Processing | UPF0224_FAM112_RNA_Proc | Family | 3,743 | true | false | The UPF0224 (FAM112) family includes proteins involved in various aspects of RNA processing and regulation of gene expression. Members of this family are implicated in the recognition of U12-type 5' splice sites, suggesting a role in the splicing of minor class introns. Some proteins within the family, such as Gametocy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21402"
] | [
"UPF0224_FAM112_RNA_Proc"
] | [
3743
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-72165",
"R-MMU-72165"
] | [
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72165"
] | 2 | [
"6x46",
"8r7n",
"8y6o",
"9gbw",
"9gc0",
"9gcl"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3743
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
4,
4,
4,
8,
3,
13,
2
] | 9 | true | Family | UPF0224 (FAM112) RNA Processing | UPF0224 (FAM112) RNA Processing | UPF0224_FAM112_RNA_Proc | 3 |
IPR051592 | 51,592 | HERV-K(HML-2) Pro peptidase A2 | HERV-K_Pro_peptidase_A2 | Family | 1,519 | true | false | The HERV-K(HML-2) Pro peptidase A2 family consists of endogenous retroviral proteases that are derived from the human endogenous retrovirus group K. These proteins are implicated in the processing of primary translation products and the maturation of viral particles. During evolution, the endogenous Pro proteins may ha... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19422"
] | [
"HERV-K_Pro_peptidase_A2"
] | [
1519
] | 1 | [
"EC"
] | [
"3.4.23.50"
] | [
"EC:3.4.23.50"
] | 1 | [
"1bai",
"1g6l",
"1hvc",
"1lv1",
"1mvp",
"1nso",
"2d4l",
"2d4m",
"2d4n",
"2o40",
"2rsp",
"2whh",
"3dox",
"3fsm",
"3gi0",
"3hlo",
"3hzc",
"3iaw",
"3ka2",
"3kt2",
"3kt5",
"3n3i",
"3nxe",
"3nxn",
"3sqf",
"3tp1",
"3tpn",
"3tps",
"3tpw",
"3tpy",
"3tq3",
"3tq4"... | 51 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Gammaproteobacteria",
"Retroviridae",
"marine sediment metagenome"
] | [
1467,
2,
49,
1
] | 4 | [
"Homo sapiens",
"Mus musculus"
] | [
14,
8
] | 2 | true | Family | HERV-K(HML-2) Pro peptidase A2 | HERV-K(HML-2) Pro peptidase A2 | HERV-K_Pro_peptidase_A2 | 9 |
IPR051593 | 51,593 | Ergosterol Biosynthesis ERG27 Subfamily | Ergosterol_Biosynth_ERG27 | Family | 2,475 | true | false | The ERG27 subfamily of the short-chain dehydrogenases/reductases (SDR) family is involved in the ergosterol biosynthesis pathway, particularly in the reduction of the keto group on the C-3 of sterols. Members of this family function as 3-keto-steroid reductases and are catalytic components of the C-4 demethylation comp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43647"
] | [
"Ergosterol_Biosynth_ERG27"
] | [
2475
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.1.1.270",
"PWY-2541",
"PWY-6074",
"PWY-8026",
"PWY-8191",
"PWY-8238",
"PWY-8239"
] | [
"EC:1.1.1.270",
"METACYC:PWY-2541",
"METACYC:PWY-6074",
"METACYC:PWY-8026",
"METACYC:PWY-8191",
"METACYC:PWY-8238",
"METACYC:PWY-8239"
] | 7 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
141,
2333,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Ergosterol Biosynthesis ERG27 Subfamily | Ergosterol Biosynthesis ERG27 Subfamily | Ergosterol_Biosynth_ERG27 | 2 |
IPR051594 | 51,594 | KRIT1/FRMD8 | KRIT1/FRMD8 | Family | 3,027 | false | false | This family of proteins includes Krev interaction trapped protein 1 (KRIT1), its paralogue FERM domain-containing protein 8 (FRMD8) and closely related proteins. Members of this entry are involved in various cellular processes, including the stabilisation of cell surface proteins, regulation of signaling pathways, and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13283"
] | [
""
] | [
3027
] | 1 | [] | [] | [] | 0 | [
"3u7d",
"4dx8",
"4dxa",
"4hdo",
"4hdq",
"5d68",
"6oq3",
"6oq4",
"6uzk",
"8su8",
"8t09",
"8t7v"
] | 12 | [
"PUB00076169",
"PUB00103011",
"PUB00154946",
"PUB00154947",
"PUB00154948",
"PUB00154949",
"PUB00154950"
] | [
"23317506",
"20668652",
"19572019",
"21633110",
"26417067",
"29897333",
"29897336"
] | [
"Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.",
"KRIT1 regulates the homeostasis of intracellular reactive oxygen species.",
"Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6.",
"A mechanism of Rap1-induced stabilization of endothelial... | [
2013,
2010,
2009,
2011,
2015,
2018,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3027
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2,
21,
6,
9
] | 6 | true | Family | KRIT1/FRMD8 | KRIT1/FRMD8 | KRIT1/FRMD8 | 7 |
IPR051595 | 51,595 | Glycosyl Hydrolase 25 Enzymes | GH25_Enzymes | Family | 1,944 | true | false | This family of proteins is characterized by glycosyl hydrolase activity, specifically within the glycosyl hydrolase 25 family. Members of this family are involved in various biological processes, including the stress response to heavy metals, limiting the size of multicellular structures during aggregation, and providi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23208"
] | [
"GH25_Enzymes"
] | [
1944
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
313,
1614,
16,
1
] | 4 | [
"Caenorhabditis elegans"
] | [
10
] | 1 | true | Family | Glycosyl Hydrolase 25 Enzymes | Glycosyl Hydrolase 25 Enzymes | GH25_Enzymes | 7 |
IPR051596 | 51,596 | Caulimoviridae Movement | Caulimoviridae_Movement | Family | 2,345 | true | false | The Caulimoviridae movement protein family is responsible for the intercellular transport of viral genomes in plant cells. These proteins facilitate the cell-to-cell propagation of viral particles by modifying plasmodesmata to allow the passage of viral ribonucleocapsids. They achieve this by forming tubule structures ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47599"
] | [
"Caulimoviridae_Movement"
] | [
2345
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Corynebacterium parakroppenstedtii",
"Euphyllophyta",
"Riboviria"
] | [
1,
2149,
195
] | 3 | [] | [] | 0 | true | Family | Caulimoviridae Movement | Caulimoviridae Movement | Caulimoviridae_Movement | 2 |
IPR051597 | 51,597 | Bifunctional protease inhibitor | Bifunctional_prot_inhibitor | Family | 696 | true | false | This family of proteins includes inhibitors with bifunctional properties, each possessing two homologous halves with active inhibitory roles. One half is responsible for inhibiting trypsin, a serine protease involved in the digestion of proteins, while the other half targets elastase, another serine protease that break... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47729"
] | [
"Bifunctional_prot_inhibitor"
] | [
696
] | 1 | [] | [] | [] | 0 | [
"1cho",
"1cso",
"1ct0",
"1ct2",
"1ct4",
"1ds2",
"1ds3",
"1hja",
"1iy5",
"1iy6",
"1m8b",
"1m8c",
"1omt",
"1omu",
"1ovo",
"1ppf",
"1r0r",
"1sgd",
"1sge",
"1sgn",
"1sgp",
"1sgq",
"1sgr",
"1sgy",
"1tur",
"1tus",
"2gkr",
"2gkt",
"2gkv",
"2nu0",
"2nu1",
"2nu2"... | 44 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Sorangium cellulosum"
] | [
691,
5
] | 2 | [
"Danio rerio"
] | [
13
] | 1 | true | Family | Bifunctional protease inhibitor | Bifunctional protease inhibitor | Bifunctional_prot_inhibitor | 8 |
IPR051598 | 51,598 | 4-Toluene sulfonate uptake permease/Inactive protease-like domain-containing protein | TSUP/Inactive_protease-like | Family | 35,353 | true | false | This family of proteins is involved in membrane transport, specifically in the uptake of solutes such as 4-toluene sulfonate. Members of this family are characterized by a conserved domain that suggests a role in the transport of specific substrates across the cell membrane, potentially functioning as permeases. Additi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43701"
] | [
"TSUP/Inactive_protease-like"
] | [
35353
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"Viruses",
"unclassified sequences"
] | [
951,
33304,
392,
1,
3,
702
] | 6 | [] | [] | 0 | true | Family | 4-Toluene sulfonate uptake permease/Inactive protease-like domain-containing protein | 4-Toluene sulfonate uptake permease/Inactive protease-like domain-containing protein | TSUP/Inactive_protease-like | 2 |
IPR051599 | 51,599 | Cell Envelope Integrity and Synthesis Associated Protein | Cell_Envelope_Assoc | Family | 36,614 | true | false | This family of proteins is involved in various cellular processes related to the integrity and function of the cell envelope. Some members are implicated in the barrier function of the cell envelope, which is crucial for maintaining the selective permeability required for cellular homeostasis and protection against env... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30336"
] | [
"Cell_Envelope_Assoc"
] | [
36614
] | 1 | [] | [] | [] | 0 | [
"3ca8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
30,
35017,
1233,
6,
328
] | 5 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
4,
2
] | 2 | true | Family | Cell Envelope Integrity and Synthesis Associated Protein | Cell Envelope Integrity and Synthesis Associated Protein | Cell_Envelope_Assoc | 8 |
IPR051600 | 51,600 | Beta-phosphoglucomutase-like | Beta-PGM-like | Family | 25,734 | true | true | This family of proteins includes enzymes that are primarily involved in the metabolism of various phosphorylated carbohydrates. The founding member of this family is Beta-phosphoglucomutase that catalyses the interconversion of D-glucose 1-phosphate and D-glucose 6-phosphate, forming beta-D-glucose 1,6-(bis)phosphate a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46193"
] | [
"Phospho_Carb_Metab_Enz"
] | [
25734
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.2.6",
"PWY-2721",
"PWY-2722",
"PWY-7459"
] | [
"EC:5.4.2.6",
"METACYC:PWY-2721",
"METACYC:PWY-2722",
"METACYC:PWY-7459"
] | 4 | [
"1lvh",
"1o03",
"1o08",
"1te2",
"1z4n",
"1z4o",
"1zol",
"2fdr",
"2wf5",
"2wf6",
"2wf7",
"2wf8",
"2wf9",
"2wfa",
"2whe",
"3e58",
"3fm9",
"3zi4",
"4c4r",
"4c4s",
"4c4t",
"4eek",
"4eel",
"4een",
"4g9b",
"4gib",
"5o6p",
"5o6r",
"5ojz",
"5ok0",
"5ok1",
"5ok2"... | 66 | [
"PUB00053777",
"PUB00091582",
"PUB00154534"
] | [
"15808744",
"16990279",
"38501428"
] | [
"Enzyme genomics: Application of general enzymatic screens to discover new enzymes.",
"Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family.",
"Biochemical and structural characterization reveals Rv3400 codes for β-phosphoglucomutase in Mycobacter... | [
2005,
2006,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
197,
23228,
2106,
13,
190
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
3,
16,
23
] | 4 | true | Family | Beta-phosphoglucomutase-like | Beta-phosphoglucomutase-like | Beta-PGM-like | 2 |
IPR051601 | 51,601 | Serine protease/Carboxylesterase S33 | Serine_prot/Carboxylest_S33 | Family | 32,876 | true | false | This family of proteins includes serine proteases and carboxylesterases that exhibit a range of activities, including cleaving tripeptides from the N-termini of proteins, modulating host immune responses, and promoting pathogenesis in certain bacterial infections. Some members have been identified as key virulence fact... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43248"
] | [
"Serine_prot/Carboxylest_S33"
] | [
32876
] | 1 | [] | [] | [] | 0 | [
"5bkm",
"5ugq",
"5uno",
"5uoh",
"7m7c",
"7sfm",
"8e18",
"8e19",
"8e5w",
"8g5t",
"8g5u",
"8jgm",
"8jgn"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natribaculum luteum",
"Nesevirus",
"metagenomes"
] | [
22250,
10452,
1,
2,
171
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
1,
3,
7,
17
] | 5 | true | Family | Serine protease/Carboxylesterase S33 | Serine protease/Carboxylesterase S33 | Serine_prot/Carboxylest_S33 | 4 |
IPR051602 | 51,602 | Acetyl-CoA Carboxylase Biotin Carboxylase Component | ACC_Biotin_Carboxylase | Family | 24,860 | true | false | This family of proteins includes enzymes that are integral components of the acetyl coenzyme A carboxylase complex. Members of this family are responsible for catalyzing the carboxylation of a carrier protein biotin, which is a crucial initial step in the biosynthesis of fatty acids. Following this, they facilitate the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48095"
] | [
"ACC_Biotin_Carboxylase"
] | [
24860
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.4.14",
"PWY-5743",
"PWY-5744",
"PWY-5789"
] | [
"EC:6.3.4.14",
"METACYC:PWY-5743",
"METACYC:PWY-5744",
"METACYC:PWY-5789"
] | 4 | [
"1bnc",
"1dv1",
"1dv2",
"1ulz",
"2c00",
"2gps",
"2gpw",
"2j9g",
"2v58",
"2v59",
"2v5a",
"2vpq",
"2vqd",
"2vr1",
"2w6m",
"2w6n",
"2w6o",
"2w6p",
"2w6q",
"2w6z",
"2w70",
"2w71",
"3g8c",
"3g8d",
"3jzf",
"3jzi",
"3ouu",
"3ouz",
"3rup",
"3rv3",
"3rv4",
"4hr7"... | 55 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
163,
23262,
1022,
413
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
8,
1
] | 2 | true | Family | Acetyl-CoA Carboxylase Biotin Carboxylase Component | Acetyl-CoA Carboxylase Biotin Carboxylase Component | ACC_Biotin_Carboxylase | 7 |
IPR051603 | 51,603 | Zinc-Containing ADH Family: Quinone Oxidoreductase/CCCR | Zinc-ADH_QOR/CCCR | Family | 28,812 | true | false | The zinc-containing alcohol dehydrogenase family, specifically the quinone oxidoreductase and crotonyl-CoA carboxylase/reductase subfamilies, includes enzymes that play roles in various metabolic processes. Quinone oxidoreductase members do not exhibit alcohol dehydrogenase activity but bind NADP and transfer electrons... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44154"
] | [
"Zinc-ADH_QOR/CCCR"
] | [
28812
] | 1 | [
"EC"
] | [
"1.6.5.5"
] | [
"EC:1.6.5.5"
] | 1 | [
"1yb5",
"2eih",
"3gaz",
"3hzz",
"3krt",
"4a0s",
"4a10",
"4dvj",
"4gi2",
"4j6f",
"4oki",
"4y0k",
"4y1b",
"5k1s",
"6na3",
"6na4",
"6na5",
"6na6",
"6owe"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1006,
24762,
2694,
350
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
4,
10,
5
] | 5 | true | Family | Zinc-Containing ADH Family: Quinone Oxidoreductase/CCCR | Zinc-Containing ADH Family: Quinone Oxidoreductase/CCCR | Zinc-ADH_QOR/CCCR | 9 |
IPR051605 | 51,605 | Peptide Transporter Carbon Starvation | CstA | Family | 16,464 | true | false | The peptide transporter carbon starvation (CstA) family is involved in the uptake and utilization of peptides, particularly under conditions of carbon starvation. Members of this family transport dipeptides and tripeptides, which can be used as carbon sources for growth and survival. The transport process is typically ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30252"
] | [
"CstA"
] | [
16464
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctzWr28",
"unclassified sequences"
] | [
410,
15790,
42,
1,
221
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Peptide Transporter Carbon Starvation | Peptide Transporter Carbon Starvation | CstA | 1 |
IPR051606 | 51,606 | Polyketide Oxidoreductase-like | Polyketide_Oxido-like | Family | 21,319 | true | false | This family of proteins includes oxidoreductases that play a crucial role in the biosynthesis of various secondary metabolites, including mycotoxins such as aflatoxins and sterigmatocystin, as well as other polyketide-derived compounds. Members of this family are involved in specific oxidation steps within the biosynth... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43355"
] | [
"Polyketide_Oxido-like"
] | [
21319
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-189483",
"R-BTA-9707564",
"R-HSA-189483",
"R-HSA-9707564",
"R-MMU-189483",
"R-MMU-9707564"
] | [
"REACTOME:R-BTA-189483",
"REACTOME:R-BTA-9707564",
"REACTOME:R-HSA-189483",
"REACTOME:R-HSA-9707564",
"REACTOME:R-MMU-189483",
"REACTOME:R-MMU-9707564"
] | 6 | [
"1hdo",
"1he2",
"1he3",
"1he4",
"1he5",
"3dhn",
"3ew7",
"3h2s",
"3qvo",
"3r6d",
"4hng",
"4hnh",
"4ipt",
"4jgb",
"4r01",
"5oog",
"5ooh",
"6opl",
"7er6",
"7er7",
"7er8",
"7er9",
"7era",
"7erb",
"7erc",
"7erd",
"7ere",
"8ell",
"8elm",
"8k4k",
"9c16",
"9c17"... | 34 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
132,
16448,
4699,
40
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
2,
6,
5,
1,
6
] | 6 | true | Family | Polyketide Oxidoreductase-like | Polyketide Oxidoreductase-like | Polyketide_Oxido-like | 4 |
IPR051607 | 51,607 | Metallo-dependent Hydrolases | Metallo-dep_hydrolases | Family | 18,972 | true | false | This family of proteins includes enzymes that catalyze the hydrolysis of specific substrates to produce ammonia. One member is known to hydrolyze N-formimino-L-glutamate to N-formyl-L-glutamate and ammonia. The majority of the family members are involved in the hydrolytic deamination of guanine to xanthine and ammonia.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11271"
] | [
"Metallo-dep_hydrolases"
] | [
18972
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.4.3",
"PWY-5497",
"PWY-6606",
"PWY-6608",
"PWY-7442",
"R-DDI-74259",
"R-DME-74259",
"R-HSA-74259",
"R-MMU-74259",
"R-RNO-74259",
"R-SCE-74259",
"R-SPO-74259"
] | [
"EC:3.5.4.3",
"METACYC:PWY-5497",
"METACYC:PWY-6606",
"METACYC:PWY-6608",
"METACYC:PWY-7442",
"REACTOME:R-DDI-74259",
"REACTOME:R-DME-74259",
"REACTOME:R-HSA-74259",
"REACTOME:R-MMU-74259",
"REACTOME:R-RNO-74259",
"REACTOME:R-SCE-74259",
"REACTOME:R-SPO-74259"
] | 12 | [
"2i9u",
"2ood",
"2uz9",
"3e0l",
"3mdu",
"3mdw",
"4aql",
"4f0l",
"4rdv",
"4rdw",
"4rzb",
"6oh9",
"6oha",
"6ohb",
"6ohc"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3,
12725,
6142,
102
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
1,
1,
1,
1,
7,
8,
2,
4,
1,
1
] | 10 | true | Family | Metallo-dependent Hydrolases | Metallo-dependent Hydrolases | Metallo-dep_hydrolases | 1 |
IPR051609 | 51,609 | NmrA-type/Isoflavone reductase-like domain-containing protein | NmrA/Isoflavone_reductase-like | Family | 22,821 | true | false | This family of proteins includes oxidoreductases involved in various biosynthetic pathways. Members of this family participate in the synthesis of diverse bioactive compounds, including cytotoxic compounds, antifungal agents, meroterpenoids, and fungal alkaloids. They function in the reduction of intermediates, catalyz... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47706"
] | [
"NmrA/Isoflavone_reductase-like"
] | [
22821
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobrevibacter millerae",
"metagenomes"
] | [
2186,
20619,
2,
14
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
5
] | 1 | true | Family | NmrA-type/Isoflavone reductase-like domain-containing protein | NmrA-type/Isoflavone reductase-like domain-containing protein | NmrA/Isoflavone_reductase-like | 9 |
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