interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051723 | 51,723 | Bacterial Outer Membrane Invasion-Related Protein | Bact_OM_Invasion-Related | Family | 5,249 | true | false | This family of proteins is involved in host-pathogen interactions, particularly during bacterial infection processes. Members are incorporated into the bacterial outer membrane and play roles in adhesion to and invasion of eukaryotic cells. Some proteins facilitate the invasion of epithelial mammalian cells by interact... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35892"
] | [
"Bact_OM_Invasion-Related"
] | [
5249
] | 1 | [] | [] | [] | 0 | [
"1orm",
"1q9f",
"1q9g",
"1qj8",
"1qj9",
"2m06",
"2m07",
"2mnh",
"2n2l",
"2n2m",
"3qra",
"3qrc",
"5vj8",
"8qpw"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
5161,
80,
5,
3
] | 4 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | Bacterial Outer Membrane Invasion-Related Protein | Bacterial Outer Membrane Invasion-Related Protein | Bact_OM_Invasion-Related | 6 |
IPR051724 | 51,724 | Actin-based Motor Myosin | Actin_motor_Myosin | Family | 6,578 | true | false | The myosin family encompasses a group of actin-based motor molecules with ATPase activity, involved in various intracellular movements. Members of this family bind to actin filaments or bundles and function as plus end-directed motors, facilitating cargo transport along actin filaments. They play critical roles in cell... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46049"
] | [
"Actin_motor_Myosin"
] | [
6578
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-9013418",
"R-DDI-9013419",
"R-DDI-9013420",
"R-DDI-9013422",
"R-DDI-9013425",
"R-HSA-2029482",
"R-HSA-373752",
"R-HSA-9664422",
"R-MMU-2029482",
"R-RNO-2029482"
] | [
"REACTOME:R-DDI-9013418",
"REACTOME:R-DDI-9013419",
"REACTOME:R-DDI-9013420",
"REACTOME:R-DDI-9013422",
"REACTOME:R-DDI-9013425",
"REACTOME:R-HSA-2029482",
"REACTOME:R-HSA-373752",
"REACTOME:R-HSA-9664422",
"REACTOME:R-MMU-2029482",
"REACTOME:R-RNO-2029482"
] | 10 | [
"3au4",
"3au5",
"3pzd",
"3tfm",
"5ejq",
"5ejy",
"5hmo",
"5i0h",
"5i0i",
"5kg8",
"9dfs",
"9dfv"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
6576
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
12,
5,
18,
16,
8,
7
] | 6 | true | Family | Actin-based Motor Myosin | Actin-based Motor Myosin | Actin_motor_Myosin | 2 |
IPR051725 | 51,725 | SAM and SH3 domain-containing protein | SAM-SH3_domain_protein | Family | 6,262 | true | false | This family of proteins includes signaling adapter molecules that may function in lymphocyte signaling, negative regulation of B-cell activation, and modulation of cell proliferation. Members are involved in cytoskeletal reorganization, cell spreading, and polarization, and can influence histone deacetylase and kinase ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12301"
] | [
"SAM-SH3_domain_protein"
] | [
6262
] | 1 | [] | [] | [] | 0 | [
"1v38",
"2dl0",
"2ebp",
"2k4p",
"2kso",
"5zrz",
"6fxf",
"6g8o",
"6uzj",
"8j1i"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6262
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
46,
13,
11,
10,
15
] | 5 | true | Family | SAM and SH3 domain-containing protein | SAM and SH3 domain-containing protein | SAM-SH3_domain_protein | 7 |
IPR051726 | 51,726 | Chitin Synthase Regulator | Chitin_Synth_Reg | Family | 6,129 | true | false | This family of proteins includes regulators of chitin synthase, an enzyme responsible for the biosynthesis of chitin. Chitin is a key structural polymer in fungal cell walls. Members of this family are involved in the activation and regulation of chitin synthase activity, which is crucial for cell wall integrity, septu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46430"
] | [
"Chitin_Synth_Reg"
] | [
6129
] | 1 | [] | [] | [] | 0 | [
"6ok0",
"6orc"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanoplasma termitum",
"Eukaryota",
"Hyperionvirus sp.",
"ecological metagenomes"
] | [
313,
1,
5803,
1,
11
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
4
] | 3 | true | Family | Chitin Synthase Regulator | Chitin Synthase Regulator | Chitin_Synth_Reg | 4 |
IPR051727 | 51,727 | DnaJ Homolog Subfamily C Member 3 Co-Chaperones | DnaJ_C3_Co-chaperones | Family | 4,981 | true | false | The DnaJ homolog subfamily C member 3 protein family is involved in various stress response mechanisms, particularly the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Family members act as co-chaperones, interacting with molecular chaperones such as HSPA8/HSC70 to stimulate ATPase activity a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44140"
] | [
"DnaJ_C3_Co-chaperones"
] | [
4981
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-192823",
"R-HSA-381038",
"R-HSA-381426",
"R-HSA-6798695",
"R-HSA-8957275",
"R-HSA-9833482",
"R-MMU-381426",
"R-MMU-6798695",
"R-MMU-8957275",
"R-MMU-9833482",
"R-RNO-381426",
"R-RNO-6798695",
"R-RNO-8957275",
"R-RNO-9833482",
"R-SCE-6798695"
] | [
"REACTOME:R-HSA-192823",
"REACTOME:R-HSA-381038",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8957275",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-8957275",
"REACTOME:R-MMU-9833482",
"REACTOME:R-RNO-381426",
"REACTOME:R-R... | 15 | [
"2y4t",
"2y4u",
"3ieg"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus phage PBC2",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1,
410,
4560,
10
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
3,
1,
3,
3,
1,
3,
1
] | 8 | true | Family | DnaJ Homolog Subfamily C Member 3 Co-Chaperones | DnaJ Homolog Subfamily C Member 3 Co-Chaperones | DnaJ_C3_Co-chaperones | 3 |
IPR051728 | 51,728 | RING-FYVE domain-containing E3 ubiquitin-protein ligase | RING-FYVE_E3_ubiquitin-ligase | Family | 5,108 | true | false | This family of proteins functions as E3 ubiquitin-protein ligases, which play a crucial role in the ubiquitin-proteasome system. They are responsible for the transfer of ubiquitin from E2 enzymes to specific substrate proteins, marking them for proteasomal degradation. This process is essential for regulating a variety... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14879"
] | [
"RING-FYVE_E3_ubiquitin-ligase"
] | [
5108
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-6804757",
"R-BTA-983168",
"R-HSA-6804757",
"R-HSA-983168",
"R-MMU-6804757",
"R-MMU-983168",
"R-RNO-6804757",
"R-RNO-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-6804757",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-6804757",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-6804757",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-6804757",
"REACTOME:R-RNO-983168"
] | 10 | [
"1y02",
"2yhn",
"2yho",
"9sa1",
"9sa2"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5069,
25,
14
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
12,
3,
10,
8,
12,
5
] | 6 | true | Family | RING-FYVE domain-containing E3 ubiquitin-protein ligase | RING-FYVE domain-containing E3 ubiquitin-protein ligase | RING-FYVE_E3_ubiquitin-ligase | 9 |
IPR051729 | 51,729 | Opine/Lysopine Dehydrogenase | Opine/Lysopine_DH | Family | 3,255 | true | false | This family of proteins is involved in the reductive condensation of pyruvate with various amino acids to form corresponding opines. These reactions typically utilize NADPH as the preferred cofactor, although NADH can also be used. The family includes enzymes that act on arginine, lysine, histidine, or octopine, produc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38015"
] | [
"Opine/Lysopine_DH"
] | [
3255
] | 1 | [
"EC"
] | [
"1.5.1"
] | [
"EC:1.5.1"
] | 1 | [
"1bg6",
"3c7a",
"3c7c",
"3c7d",
"3iqd"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
14,
2204,
984,
53
] | 4 | [] | [] | 0 | true | Family | Opine/Lysopine Dehydrogenase | Opine/Lysopine Dehydrogenase | Opine/Lysopine_DH | 4 |
IPR051730 | 51,730 | Nuclear autoantigenic sperm protein-like | NASP-like | Family | 5,724 | true | true | This family of eukaryotic proteins includes human Nuclear autoantigenic sperm protein (NASP), a component of the histone chaperone network [ ]. Members of this family are involved in various cellular processes related to DNA replication, cell cycle progression, and cell proliferation. They form complexes with HSP90 and... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15081"
] | [
"NASP-associated_protein"
] | [
5724
] | 1 | [] | [] | [] | 0 | [
"7v1k",
"7v1l",
"7v1m",
"7v6p",
"7v6q",
"7w5m"
] | 6 | [
"PUB00155041"
] | [
"22195965"
] | [
"A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillaceae",
"Dickeya phage vB_DsoM_JA29",
"Eukaryota"
] | [
5,
1,
5718
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
6,
2,
4,
1,
14,
4,
1,
4,
6,
1,
41
] | 11 | true | Family | Nuclear autoantigenic sperm protein-like | Nuclear autoantigenic sperm protein-like | NASP-like | 5 |
IPR051732 | 51,732 | Upstream Stimulatory Factor | USF | Family | 4,826 | true | false | The Upstream Stimulatory Factor family comprises transcription factors that recognize and bind to E-boxes with the consensus DNA sequence 5'-CACGTG-3'. These binding sites are commonly found in the promoters of various viral and cellular genes, indicating a role for the family in the regulation of gene expression. Memb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46117"
] | [
"USF"
] | [
4826
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9018519",
"R-BTA-9824585",
"R-HSA-9018519",
"R-HSA-9824585",
"R-MMU-9018519",
"R-MMU-9824585"
] | [
"REACTOME:R-BTA-9018519",
"REACTOME:R-BTA-9824585",
"REACTOME:R-HSA-9018519",
"REACTOME:R-HSA-9824585",
"REACTOME:R-MMU-9018519",
"REACTOME:R-MMU-9824585"
] | 6 | [
"1an4",
"8ia3"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4823,
3
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
30,
2,
18,
11,
1,
8,
1
] | 7 | true | Family | Upstream Stimulatory Factor | Upstream Stimulatory Factor | USF | 3 |
IPR051733 | 51,733 | WD repeat-containing DCAF13/WDSOF1 | WD_repeat_DCAF13/WDSOF1 | Family | 5,396 | true | false | This family of proteins is involved in various cellular processes, including the assembly of the small subunit processome, a precursor to the small eukaryotic ribosomal subunit. They are implicated in ribosomal RNA processing, which involves RNA folding, modifications, rearrangements, and cleavage, as well as targeted ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22851"
] | [
"WD_repeat_DCAF13/WDSOF1"
] | [
5396
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6791226",
"R-DDI-8951664",
"R-DRE-8951664",
"R-HSA-6790901",
"R-HSA-6791226",
"R-HSA-8951664",
"R-MMU-6791226",
"R-MMU-8951664",
"R-SCE-6791226",
"R-SPO-6791226",
"R-SPO-8951664",
"R-XTR-8951664"
] | [
"REACTOME:R-DDI-6791226",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DRE-8951664",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-6791226",
"REACTOME:R-MMU-8951664",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226",
"REACTOME:R-SPO-8951664",
"REACTOM... | 12 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 41 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5396
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
3,
5,
1,
1,
3,
3,
1,
1,
6
] | 12 | true | Family | WD repeat-containing DCAF13/WDSOF1 | WD repeat-containing DCAF13/WDSOF1 | WD_repeat_DCAF13/WDSOF1 | 9 |
IPR051734 | 51,734 | Type II toxin-antitoxin VapB antitoxins | VapB_TA_antitoxins | Family | 3,494 | true | false | The VapB family consists of antitoxin components within type II toxin-antitoxin (TA) systems. Members of the VapB family are responsible for neutralizing the effects of cognate toxins, named VapC, thereby preventing harmful activity within the host organism. These antitoxins can inhibit the RNase activity of their cogn... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37550"
] | [
"VapB_TA_antitoxins"
] | [
3494
] | 1 | [] | [] | [] | 0 | [
"3tnd",
"3zvk",
"6ifm",
"6nkl",
"6sd6",
"9h6a",
"9h6b",
"9h6c",
"9h6d"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina mazei",
"metagenomes"
] | [
3442,
7,
1,
44
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type II toxin-antitoxin VapB antitoxins | Type II toxin-antitoxin VapB antitoxins | VapB_TA_antitoxins | 3 |
IPR051735 | 51,735 | CFEM domain-containing protein | CFEM_domain | Family | 4,988 | true | false | This family of proteins includes GPI-anchored cell wall proteins and effectors with a CFEM domain, which is characterized by a unique helical-basket fold stabilized by disulfide bonds. The family members are involved in various functions related to fungal pathogenicity, including cell wall stabilization, heme-binding, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37928"
] | [
"CFEM_domain"
] | [
4988
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4988
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Zea mays"
] | [
7,
1
] | 2 | true | Family | CFEM domain-containing protein | CFEM domain-containing protein | CFEM_domain | 8 |
IPR051737 | 51,737 | L-xylulose reductase/Carbonyl reductase | L-xylulose/Carbonyl_redctase | Family | 4,042 | true | false | The L-xylulose reductase family comprises enzymes that catalyze the NADPH-dependent reduction of various sugars and alpha-dicarbonyl compounds. Members of this family participate in the uronate cycle of glucose metabolism and may contribute to cellular osmoregulation in renal tubules by producing xylitol, an osmolyte. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44252"
] | [
"L-xylulose/Carbonyl_redctase"
] | [
4042
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1.10",
"PWY-5515",
"PWY-5525",
"R-BTA-5661270",
"R-CEL-5661270",
"R-GGA-5661270",
"R-HSA-5661270",
"R-HSA-5662853",
"R-MMU-5661270",
"R-RNO-5661270"
] | [
"EC:1.1.1.10",
"METACYC:PWY-5515",
"METACYC:PWY-5525",
"REACTOME:R-BTA-5661270",
"REACTOME:R-CEL-5661270",
"REACTOME:R-GGA-5661270",
"REACTOME:R-HSA-5661270",
"REACTOME:R-HSA-5662853",
"REACTOME:R-MMU-5661270",
"REACTOME:R-RNO-5661270"
] | 10 | [
"1cyd",
"1pr9",
"1wnt",
"3d3w",
"4egf"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1612,
2394,
36
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
9,
5,
11
] | 6 | true | Family | L-xylulose reductase/Carbonyl reductase | L-xylulose reductase/Carbonyl reductase | L-xylulose/Carbonyl_redctase | 1 |
IPR051739 | 51,739 | Rhomboid-related Intramembrane Serine Proteases | Rhomboid_IM_Serine_Proteases | Family | 5,058 | true | false | The Rhomboid-related protein family is characterized by its involvement in regulated intramembrane proteolysis, which facilitates the release of functional polypeptides from their membrane anchors. Members of this family are known to cleave specific substrates, such as EFNB3, and participate in critical signaling pathw... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45840"
] | [
"Rhomboid_IM_Serine_Proteases"
] | [
5058
] | 1 | [
"EC"
] | [
"3.4.21.105"
] | [
"EC:3.4.21.105"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aureococcus anophagefferens virus",
"Eukaryota",
"Rhodobacterales",
"bird metagenome"
] | [
1,
5054,
2,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
28,
12,
8,
6,
9
] | 6 | true | Family | Rhomboid-related Intramembrane Serine Proteases | Rhomboid-related Intramembrane Serine Proteases | Rhomboid_IM_Serine_Proteases | 5 |
IPR051740 | 51,740 | Double-stranded RNA-binding domain-containing protein | DRBM-containing_protein | Family | 4,709 | true | false | This family of proteins includes RNA-binding proteins that are involved in the transport and localization of RNAs within cells. They play a critical role in the microtubule-dependent transport of RNAs, particularly in polarized and neuronal cell types, facilitating the localization of specific mRNAs to dendrites and ot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46054"
] | [
"DRBM-containing_protein"
] | [
4709
] | 1 | [] | [] | [] | 0 | [
"1ekz",
"1stu",
"1uhz",
"4dkk",
"5cff",
"6htu",
"6sdw",
"6sdy",
"7e4v"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Desulfobacca acetoxidans",
"Eumetazoa"
] | [
1,
4708
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
10,
2,
24,
22,
12
] | 6 | true | Family | Double-stranded RNA-binding domain-containing protein | Double-stranded RNA-binding domain-containing protein | DRBM-containing_protein | 9 |
IPR051741 | 51,741 | Partitioning defective 6 homolog protein | PAR6_homolog | Family | 4,618 | true | false | This family of proteins is involved in the regulation of asymmetrical cell division and cell polarization processes. Members of this family function as adapter proteins that are likely to be involved in the formation of epithelial tight junctions. They are known to interact with Rho small GTPases and atypical protein k... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14102"
] | [
"PAR6_homolog"
] | [
4618
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-2173791",
"R-CEL-9013149",
"R-CEL-9013420",
"R-CEL-9013424",
"R-HSA-2173791",
"R-HSA-420029",
"R-HSA-4608870",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013420",
"R-HSA-9013424",
"R-MMU-2173791",
"R-MMU-420029",
"R-MMU-4608870",
"R-MMU-9013149",
"R-MMU-9013420",
"R-MMU-9013424... | [
"REACTOME:R-CEL-2173791",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013420",
"REACTOME:R-CEL-9013424",
"REACTOME:R-HSA-2173791",
"REACTOME:R-HSA-420029",
"REACTOME:R-HSA-4608870",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013420",
"REACTOME:R-HSA-9013424",
"REACTOME... | 23 | [
"1nf3",
"1ry4",
"1rzx",
"1wmh",
"1x8s",
"2lc6",
"2lc7",
"5i7z",
"8r3y",
"9ejk",
"9ejl",
"9ejm"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4618
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
13,
1,
10,
12,
15
] | 6 | true | Family | Partitioning defective 6 homolog protein | Partitioning defective 6 homolog protein | PAR6_homolog | 9 |
IPR051743 | 51,743 | TAFA chemokine-like | TAFA_chemokine-like | Family | 4,359 | true | false | This family of proteins includes chemokine-like factors that are involved in various biological processes related to the immune system and neuronal functions. Members of this family have been shown to play roles in modulating pain hypersensitivity, chemoattracting macrophages, promoting phagocytosis, and increasing rea... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31770"
] | [
"TAFA_chemokine-like"
] | [
4359
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
4359
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
9,
6,
13
] | 4 | true | Family | TAFA chemokine-like | TAFA chemokine-like | TAFA_chemokine-like | 4 |
IPR051744 | 51,744 | AP2-associated Ser/Thr protein kinase | AP2_assoc_SerThr_kinase | Family | 4,511 | true | false | The AP2-associated protein kinase family is involved in the regulation of clathrin-mediated endocytosis. Members of this family phosphorylate the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2), enhancing AP-2's affinity for cargo membrane proteins during endocytosis initiation. They may preferentially phosph... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47907"
] | [
"AP2_assoc_SerThr_kinase"
] | [
4511
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-HSA-8856825",
"R-HSA-8856828",
"R-MMU-8856825",
"R-MMU-8856828",
"R-RNO-8856825",
"R-RNO-8856828"
] | [
"EC:2.7.11.1",
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-MMU-8856825",
"REACTOME:R-MMU-8856828",
"REACTOME:R-RNO-8856825",
"REACTOME:R-RNO-8856828"
] | 7 | [
"4w9w",
"4w9x",
"4wsq",
"5i3o",
"5i3r",
"5ikw",
"5l4q",
"5te0",
"7lvh",
"7lvi",
"7rj6",
"7rj7",
"7rj8",
"8gmc",
"8gmd",
"9qb5"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4511
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
38,
13,
6,
17
] | 4 | true | Family | AP2-associated Ser/Thr protein kinase | AP2-associated Ser/Thr protein kinase | AP2_assoc_SerThr_kinase | 3 |
IPR051745 | 51,745 | Intracellular Transport Effector | Intracell_Transport_Effector | Family | 4,410 | true | false | This family of proteins includes effectors involved in intracellular transport processes, particularly in the trafficking and stabilization of cellular components. Members of this family function as linkers that connect vesicles or organelles to motor proteins, facilitating their movement along cytoskeletal elements. S... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14555"
] | [
"Intracell_Transport_Effector"
] | [
4410
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-264876",
"R-HSA-8986944",
"R-HSA-9824585",
"R-MMU-9824585",
"R-RNO-9824585"
] | [
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-8986944",
"REACTOME:R-HSA-9824585",
"REACTOME:R-MMU-9824585",
"REACTOME:R-RNO-9824585"
] | 5 | [
"2zet"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4410
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
19,
12,
16
] | 4 | true | Family | Intracellular Transport Effector | Intracellular Transport Effector | Intracell_Transport_Effector | 2 |
IPR051746 | 51,746 | Kelch domain-containing protein 8 | Kelch_domain_containing_8 | Family | 3,216 | true | false | This family of proteins is involved in the final stages of cell division, specifically cytokinesis. Members of this family play a crucial role in ensuring the proper separation and distribution of chromosomes into daughter cells. They are essential for maintaining mitotic integrity, chromosomal stability, and preventin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46260"
] | [
"Kelch_domain_containing_8"
] | [
3216
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-4641258",
"R-DDI-5658442",
"R-DDI-8951664",
"R-DDI-9755511",
"R-DDI-983168"
] | [
"REACTOME:R-DDI-4641258",
"REACTOME:R-DDI-5658442",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DDI-983168"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Chordopoxvirinae",
"Eukaryota",
"metagenomes"
] | [
13,
590,
3,
2598,
12
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
10,
5,
6
] | 4 | true | Family | Kelch domain-containing protein 8 | Kelch domain-containing protein 8 | Kelch_domain_containing_8 | 9 |
IPR051747 | 51,747 | Angiomotin-like | Angiomotin-like | Family | 4,186 | false | false | This family of proteins includes Angiomotin and related proteins. These proteins are involved in the regulation of cell polarity, proliferation, and migration, particularly in endothelial cells. They play a key role in angiogenesis and the maintenance of actin filament architecture [ , ]. Angiomotin-like protein 2 inhi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14826"
] | [
""
] | [
4186
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2028269",
"R-CFA-2028269",
"R-DRE-2028269",
"R-HSA-2028269",
"R-HSA-9762292",
"R-MMU-2028269",
"R-MMU-9762292",
"R-RNO-2028269"
] | [
"REACTOME:R-BTA-2028269",
"REACTOME:R-CFA-2028269",
"REACTOME:R-DRE-2028269",
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-9762292",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-9762292",
"REACTOME:R-RNO-2028269"
] | 8 | [] | 0 | [
"PUB00154976",
"PUB00154977",
"PUB00154978"
] | [
"21205866",
"28842668",
"34404733"
] | [
"Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.",
"The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching.",
"AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation."
] | [
2011,
2017,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4186
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
16,
17,
13
] | 5 | true | Family | Angiomotin-like | Angiomotin-like | Angiomotin-like | 5 |
IPR051748 | 51,748 | Tumor Necrosis Factor Ligand Superfamily | TNF_Ligand_Superfamily | Family | 4,172 | true | false | The protein family is part of the tumor necrosis factor superfamily, which includes cytokines involved in a wide range of biological processes such as cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Members of this family are key players in the immune system and inflammatory response.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15151"
] | [
"TNF_Ligand_Superfamily"
] | [
4172
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-450520",
"R-HSA-450520",
"R-HSA-5668541",
"R-HSA-5669034",
"R-HSA-5676594",
"R-MMU-450520",
"R-MMU-5668541",
"R-MMU-5669034",
"R-MMU-5676594"
] | [
"REACTOME:R-DME-450520",
"REACTOME:R-HSA-450520",
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5669034",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-450520",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5669034",
"REACTOME:R-MMU-5676594"
] | 9 | [
"1jh5",
"1kd7",
"1kxg",
"1oqd",
"1oqe",
"1osg",
"1rj7",
"1rj8",
"1u5x",
"1u5y",
"1u5z",
"1xu1",
"1xu2",
"3k48",
"3v56",
"4ht1",
"4v46",
"4zch",
"5y9j",
"6fxn",
"6i50",
"6zt0",
"7x9g",
"8zuj"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4172
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
22,
1,
29,
22,
20
] | 5 | true | Family | Tumor Necrosis Factor Ligand Superfamily | Tumor Necrosis Factor Ligand Superfamily | TNF_Ligand_Superfamily | 4 |
IPR051750 | 51,750 | Cystathionine gamma-synthase-like | Cyst_gamma_synthase | Family | 3,706 | true | true | The trans-sulfuration enzymes family encompasses a group of enzymes involved in various biosynthetic pathways, including the production of amino acids and cyclic peptides. Some members of this family catalyze gamma-replacement reactions to form L-cystathionine from O-succinyl-L-homoserine and L-cysteine, or gamma-elimi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42699"
] | [
"Trans-sulfuration_enzymes"
] | [
3706
] | 1 | [
"EC"
] | [
"2.5.1"
] | [
"EC:2.5.1"
] | 1 | [
"9aua",
"9aub"
] | 2 | [
"PUB00152844",
"PUB00154554"
] | [
"36715406",
"10821189"
] | [
"Biosynthetic Characterization, Heterologous Production, and Genomics-Guided Discovery of GABA-Containing Fungal Heptapeptides.",
"Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae."
] | [
2023,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
313,
3384,
9
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
1
] | 3 | true | Family | Cystathionine gamma-synthase-like | Cystathionine gamma-synthase-like | Cyst_gamma_synthase | 4 |
IPR051751 | 51,751 | Immunoreceptor signaling adapters | Immunoreceptor_sig_adapters | Family | 4,207 | true | false | This family of proteins includes adapters and linkers that play critical roles in immunoreceptor signaling pathways. They are involved in the regulation of signaling cascades downstream of various receptors such as T-cell antigen receptors, B-cell antigen receptors, and mast cell degranulation receptors. These proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14098"
] | [
"Immunoreceptor_sig_adapters"
] | [
4207
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-983695",
"R-HSA-114604",
"R-HSA-202433",
"R-HSA-2424491",
"R-HSA-2871796",
"R-HSA-2871809",
"R-HSA-912631",
"R-HSA-9679191",
"R-HSA-983695",
"R-MMU-114604",
"R-MMU-202433",
"R-MMU-2424491",
"R-MMU-2871796",
"R-MMU-2871809",
"R-MMU-983695",
"R-RNO-983695"
] | [
"REACTOME:R-GGA-983695",
"REACTOME:R-HSA-114604",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-2424491",
"REACTOME:R-HSA-2871796",
"REACTOME:R-HSA-2871809",
"REACTOME:R-HSA-912631",
"REACTOME:R-HSA-9679191",
"REACTOME:R-HSA-983695",
"REACTOME:R-MMU-114604",
"REACTOME:R-MMU-202433",
"REACTOME:R-MMU... | 16 | [
"2eo6"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4207
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
1,
26,
14,
20
] | 5 | true | Family | Immunoreceptor signaling adapters | Immunoreceptor signaling adapters | Immunoreceptor_sig_adapters | 4 |
IPR051752 | 51,752 | Mitochondrial 2-oxodicarboxylate carrier | Mito_2-oxodicarb_carrier | Family | 3,841 | true | false | This family of proteins is involved in the transport of dicarboxylates and oxodicarboxylates across the inner mitochondrial membrane. Members of this family function through a counter-exchange mechanism, facilitating the import of key metabolic intermediates into the mitochondria. These substrates include 2-oxoadipate,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46356"
] | [
"Mito_2-oxodicarb_carrier"
] | [
3841
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-71064",
"R-DDI-71064",
"R-HSA-71064",
"R-MMU-71064",
"R-RNO-71064"
] | [
"REACTOME:R-BTA-71064",
"REACTOME:R-DDI-71064",
"REACTOME:R-HSA-71064",
"REACTOME:R-MMU-71064",
"REACTOME:R-RNO-71064"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Bodocaedibacter vickermanii",
"Eukaryota"
] | [
1,
3840
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
4,
1,
3,
1,
4,
2,
1
] | 9 | true | Family | Mitochondrial 2-oxodicarboxylate carrier | Mitochondrial 2-oxodicarboxylate carrier | Mito_2-oxodicarb_carrier | 9 |
IPR051753 | 51,753 | Retinoic acid-inducible GPCR family 3 | RA-inducible_GPCR3 | Family | 3,748 | true | false | The G-protein coupled receptor 3 family is characterized by its members being retinoic acid-inducible G-protein coupled receptors, which suggests a potential interaction between retinoid and G-protein signaling pathways. Members of the family, such as Retinoic acid-induced protein 3, are implicated in modulating differ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14511"
] | [
"RA-inducible_GPCR3"
] | [
3748
] | 1 | [] | [] | [] | 0 | [
"8yzk",
"9ima"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Proboscivirus"
] | [
3739,
9
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
24,
17,
22
] | 4 | true | Family | Retinoic acid-inducible GPCR family 3 | Retinoic acid-inducible GPCR family 3 | RA-inducible_GPCR3 | 2 |
IPR051755 | 51,755 | Immunoglobulin-like Cell Surface Receptor | Ig-like_CS_Receptor | Family | 3,785 | true | false | This family of proteins includes immunoglobulin-like cell surface receptors that are involved in various cellular processes such as negative regulation of receptor tyrosine kinase-coupled signaling, cell adhesion, neurite outgrowth, and immune responses. Members act as docking proteins, mediating translocation of phosp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19971"
] | [
"Ig-like_CS_Receptor"
] | [
3785
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-2172127",
"R-HSA-391160",
"R-HSA-6798695",
"R-MMU-202733",
"R-MMU-391160",
"R-MMU-6798695",
"R-RNO-202733",
"R-RNO-391160",
"R-RNO-6798695"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-2172127",
"REACTOME:R-HSA-391160",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-391160",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-202733",
"REACTOME:R-RNO-391160",
"REACTOME:R-RNO-6798695"
] | 10 | [
"1hxm",
"2d9c",
"2jjs",
"2jjt",
"2jju",
"2jjv",
"2jjw",
"2uv3",
"2wng",
"2yz1",
"4cmm",
"4i2x",
"4kjy",
"6bit",
"6lyc",
"6nmr",
"6nms",
"6nmt",
"6nmu",
"6nmv",
"7kpg",
"7st5",
"7ygg",
"8dfw",
"8jc0",
"8wy0",
"8wyi",
"8yc0",
"9cq4",
"9cq7",
"9j5j",
"9j5m"... | 35 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3785
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
26,
29,
15
] | 4 | true | Family | Immunoglobulin-like Cell Surface Receptor | Immunoglobulin-like Cell Surface Receptor | Ig-like_CS_Receptor | 1 |
IPR051756 | 51,756 | Centrosomal microtubule-associated protein | Centrosomal_MT-associated | Family | 3,598 | true | false | This family of proteins is involved in the organization and function of centrosomes, which are key structures for microtubule organization and spindle assembly during cell division. Members of this family are characterized by their ability to localize to centrosomes and to interact with microtubules, potentially formin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19336"
] | [
"Centrosomal_MT-associated"
] | [
3598
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [
"4l0r",
"8ibh"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3598
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
7,
24,
14,
1,
14,
1
] | 6 | true | Family | Centrosomal microtubule-associated protein | Centrosomal microtubule-associated protein | Centrosomal_MT-associated | 2 |
IPR051757 | 51,757 | Beta-galactoside alpha2-3 sialyltransferases | Beta-gal_alpha2-3_sialyltrans | Family | 3,512 | true | false | This family of proteins includes enzymes known as beta-galactoside alpha2-3 sialyltransferases, which are involved in the terminal sialylation of glycoproteins and glycolipids. These enzymes catalyze the transfer of sialic acid from the nucleotide sugar donor CMP-Neu5Ac onto acceptor substrates that terminate with Galb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46032"
] | [
"Beta-gal_alpha2-3_sialyltrans"
] | [
3512
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"2.4.3.2",
"2.4.3.4",
"PWY-7433",
"PWY-7832",
"PWY-7836",
"PWY-7838",
"R-GGA-2022854",
"R-GGA-4085001",
"R-GGA-977068",
"R-HSA-2022854",
"R-HSA-4085001",
"R-HSA-9683673",
"R-HSA-9694548",
"R-HSA-9694719",
"R-HSA-977068",
"R-HSA-9840309",
"R-MMU-2022854",
"R-MMU-4085001",
"R-MMU-9... | [
"EC:2.4.3.2",
"EC:2.4.3.4",
"METACYC:PWY-7433",
"METACYC:PWY-7832",
"METACYC:PWY-7836",
"METACYC:PWY-7838",
"REACTOME:R-GGA-2022854",
"REACTOME:R-GGA-4085001",
"REACTOME:R-GGA-977068",
"REACTOME:R-HSA-2022854",
"REACTOME:R-HSA-4085001",
"REACTOME:R-HSA-9683673",
"REACTOME:R-HSA-9694548",
"... | 24 | [
"2wml",
"2wnb",
"2wnf"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3512
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
9,
15,
8
] | 4 | true | Family | Beta-galactoside alpha2-3 sialyltransferases | Beta-galactoside alpha2-3 sialyltransferases | Beta-gal_alpha2-3_sialyltrans | 7 |
IPR051758 | 51,758 | Ethylene-responsive transcription factor ERF/AP2-like | ERF/AP2-like | Family | 4,641 | true | false | This family of proteins includes transcriptional activators that are involved in the regulation of gene expression in response to various stress factors. Members of this family are characterized by their ability to bind to specific DNA elements, such as the GCC-box pathogenesis-related promoter element and the DRE elem... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31657"
] | [
"ERF/AP2-like"
] | [
4641
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Deinococcus enclensis",
"Viridiplantae"
] | [
1,
4640
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
39,
28,
38
] | 3 | true | Family | Ethylene-responsive transcription factor ERF/AP2-like | Ethylene-responsive transcription factor ERF/AP2-like | ERF/AP2-like | 9 |
IPR051760 | 51,760 | Histone-lysine N-methyltransferase KMT5A | KMT5A | Family | 3,741 | true | false | This family of proteins includes N-lysine methyltransferases that specifically target 'Lys-20' of histone H4, marking it with a monomethyl group (H4K20me1). This modification is associated with epigenetic transcriptional repression and is particularly enriched during mitosis. These proteins are crucial for cell prolife... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46167"
] | [
"KMT5A"
] | [
3741
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"2.1.1.-",
"2.1.1.361",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601... | [
"EC:2.1.1.-",
"EC:2.1.1.361",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729"... | 172 | [
"1zkk",
"2bqz",
"3f9w",
"3f9x",
"3f9y",
"3f9z",
"4ij8",
"4ldg",
"5hq2",
"5t5g",
"5teg",
"5th7",
"5v2n",
"5w1y",
"6boz",
"7d1z",
"7d20",
"7xpx",
"9cr7"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Adomaviruses",
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
2,
97,
3640,
2
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
2,
3,
5,
10
] | 6 | true | Family | Histone-lysine N-methyltransferase KMT5A | Histone-lysine N-methyltransferase KMT5A | KMT5A | 3 |
IPR051761 | 51,761 | MLP-like hydrophobic ligand-binding | MLP-like_ligand-binding | Family | 4,643 | true | false | This family of proteins includes members that are known to bind hydrophobic ligands, such as steroids, in vitro. The binding activity suggests a potential role in the interaction with or regulation of lipid-based molecules within the cell. The similarity annotations indicate that these proteins share common structural ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31907"
] | [
"MLP-like_ligand-binding"
] | [
4643
] | 1 | [] | [] | [] | 0 | [
"1vjh",
"2i9y",
"2q3q",
"4igv",
"4igw",
"4igx",
"4igy",
"4ih0",
"4ih2",
"4ihr",
"4reh",
"4rei",
"4rej"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Corallococcus caeni",
"Spermatophyta"
] | [
1,
4642
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
58,
4,
4
] | 3 | true | Family | MLP-like hydrophobic ligand-binding | MLP-like hydrophobic ligand-binding | MLP-like_ligand-binding | 7 |
IPR051762 | 51,762 | Upstream Binding Factor 1 | UBF1 | Family | 3,082 | true | false | The UBF1 family proteins are primarily involved in the regulation of ribosomal RNA (rRNA) gene transcription. They recognize the rRNA gene promoter and activate transcription mediated by RNA polymerase I. This is achieved through cooperative interactions with the SL1/TIF-IB complex, to which they bind specifically at t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46318"
] | [
"UBF1"
] | [
3082
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-427413",
"R-HSA-73728",
"R-HSA-73762",
"R-HSA-73772",
"R-HSA-73863",
"R-MMU-73728",
"R-MMU-73762",
"R-MMU-73772",
"R-MMU-73863",
"R-RNO-73728",
"R-RNO-73762",
"R-RNO-73772",
"R-RNO-73863"
] | [
"REACTOME:R-HSA-427413",
"REACTOME:R-HSA-73728",
"REACTOME:R-HSA-73762",
"REACTOME:R-HSA-73772",
"REACTOME:R-HSA-73863",
"REACTOME:R-MMU-73728",
"REACTOME:R-MMU-73762",
"REACTOME:R-MMU-73772",
"REACTOME:R-MMU-73863",
"REACTOME:R-RNO-73728",
"REACTOME:R-RNO-73762",
"REACTOME:R-RNO-73772",
"RE... | 13 | [
"1k99",
"1l8y",
"1l8z",
"1v63",
"1v64",
"2hdz"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3082
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
52,
13,
9,
4
] | 5 | true | Family | Upstream Binding Factor 1 | Upstream Binding Factor 1 | UBF1 | 7 |
IPR051764 | 51,764 | Avidin/Streptavidin-related | Avidin/Streptavidin-rel | Family | 2,617 | true | false | This family of proteins is characterized by their ability to form strong non-covalent specific complexes with biotin, with one molecule of biotin binding per subunit. The exact biological function of these proteins is not fully understood, but their high affinity for biotin is a defining feature. The family includes bo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34399"
] | [
"Avidin/Streptavidin-rel"
] | [
2617
] | 1 | [] | [] | [] | 0 | [
"1avd",
"1ave",
"1df8",
"1hqq",
"1hxl",
"1hxz",
"1hy2",
"1i9h",
"1ij8",
"1kff",
"1kl3",
"1kl4",
"1kl5",
"1lcv",
"1lcw",
"1lcz",
"1ldo",
"1ldq",
"1lel",
"1luq",
"1mep",
"1mk5",
"1mm9",
"1moy",
"1n43",
"1n4j",
"1n7y",
"1n9m",
"1n9y",
"1nbx",
"1nc9",
"1ndj"... | 363 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrosopumilus ureiphilus",
"Pithoviruses",
"metagenomes"
] | [
221,
2390,
1,
2,
3
] | 5 | [
"Danio rerio"
] | [
2
] | 1 | true | Family | Avidin/Streptavidin-related | Avidin/Streptavidin-related | Avidin/Streptavidin-rel | 8 |
IPR051766 | 51,766 | Thioredoxin domain-containing protein | TXND_domain-containing | Family | 2,841 | true | false | This family of proteins includes members that are suggested to play roles in the regulation of microtubule physiology and redox state regulation within cellular components such as dynein. Some proteins within this family are implicated in sperm tail maturation, potentially acting by modulating disulfide bonds during th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46135"
] | [
"TXND_domain-containing"
] | [
2841
] | 1 | [] | [] | [] | 0 | [
"8glv",
"8j07"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2841
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
4,
9,
3,
7
] | 5 | true | Family | Thioredoxin domain-containing protein | Thioredoxin domain-containing protein | TXND_domain-containing | 2 |
IPR051767 | 51,767 | Nucleoporin NUP42 domain-containing protein | Nucleoporin_NUP42 | Family | 3,180 | true | true | NUP42 is a component of the nuclear pore complex required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. The protein localises to the nuclear pore complex at the nuclear membrane. NUP42 contains an N-terminal C3H1-type zinc finger domain and multiple FG repeats that serve as inter... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46527"
] | [
"Nucleoporin_NUP42"
] | [
3180
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 66 | [
"6b4f",
"6b4i",
"6b4j",
"7tbl"
] | 4 | [
"PUB00162204"
] | [
"10358091"
] | [
"A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3180
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
4,
4,
6,
3,
1,
4,
1,
1,
6
] | 10 | true | Family | Nucleoporin NUP42 domain-containing protein | Nucleoporin NUP42 domain-containing protein | Nucleoporin_NUP42 | 1 |
IPR051768 | 51,768 | Bacterial secretion system and toxin | Bact_secretion_toxin | Family | 1,808 | true | false | This family of proteins includes components of bacterial secretion systems and toxins involved in intercellular competition and biofilm formation. Members are implicated in the secretion of specific effector molecules, such as EsxA, and play roles in bacterial virulence, including abscess formation and persistence with... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34976"
] | [
"Bact_secretion_toxin"
] | [
1808
] | 1 | [] | [] | [] | 0 | [
"8gun",
"8guo"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"human gut metagenome"
] | [
1805,
2,
1
] | 3 | [] | [] | 0 | true | Family | Bacterial secretion system and toxin | Bacterial secretion system and toxin | Bact_secretion_toxin | 5 |
IPR051770 | 51,770 | Forkhead box transcription regulator | Forkhead_box_regulator | Family | 2,318 | true | false | This family of proteins includes transcription factors characterized by a conserved forkhead domain. Members of this family are involved in the regulation of gene expression, particularly in the development and differentiation of various tissues. They act as transcription activators for lung-specific genes and play rol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46262"
] | [
"Forkhead_box_regulator"
] | [
2318
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-3232118",
"R-HSA-9758920",
"R-HSA-9762293"
] | [
"REACTOME:R-CEL-3232118",
"REACTOME:R-HSA-9758920",
"REACTOME:R-HSA-9762293"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2318
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
2,
2,
5
] | 6 | true | Family | Forkhead box transcription regulator | Forkhead box transcription regulator | Forkhead_box_regulator | 9 |
IPR051771 | 51,771 | FAM167 domain-containing protein | FAM167_domain | Family | 2,374 | true | false | This family of proteins is characterized by a shared domain indicative of a common evolutionary origin. Members of this family are involved in various cellular processes, although specific functions may vary among individual proteins. The presence of alanine and arginine-rich regions suggests potential roles in protein... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32289"
] | [
"FAM167_domain"
] | [
2374
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2374
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
11,
6,
10
] | 4 | true | Family | FAM167 domain-containing protein | FAM167 domain-containing protein | FAM167_domain | 2 |
IPR051772 | 51,772 | Gastrokine | Gastrokine | Family | 2,174 | true | false | The gastrokine family comprises proteins involved in the maintenance and integrity of the gastric mucosal epithelium. Members of this family exhibit mitogenic activity, suggesting a role in cell proliferation and tissue regeneration. Some gastrokines are also implicated in inhibiting gastric epithelial cell proliferati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16483"
] | [
"Gastrokine"
] | [
2174
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2174
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
9,
7,
10
] | 4 | true | Family | Gastrokine | Gastrokine | Gastrokine | 3 |
IPR051773 | 51,773 | XK-related membrane adapter | XK-related_adapter | Family | 1,931 | true | false | This family of proteins is involved in the intracellular transport of lipids. Members of this family function as membrane adapter proteins that facilitate the recruitment of the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. This recruitment is essential for the maintenanc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14297"
] | [
"XK-related_adapter"
] | [
1931
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-MMU-375276",
"R-RNO-375276"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-MMU-375276",
"REACTOME:R-RNO-375276"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1931
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
12,
4,
6
] | 4 | true | Family | XK-related membrane adapter | XK-related membrane adapter | XK-related_adapter | 4 |
IPR051774 | 51,774 | Sperm-specific class P | Sperm-specific_class_P | Family | 1,691 | true | false | This family of proteins includes sperm-specific proteins that are likely involved in the process of spermatogenesis or the structural and functional properties of sperm cells. The proteins are designated as 'class P', which may suggest a particular class within a broader category of sperm-specific proteins. The exact f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22947"
] | [
"Sperm-specific_class_P"
] | [
1691
] | 1 | [] | [] | [] | 0 | [
"1m1s",
"1row"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1691
] | 1 | [
"Caenorhabditis elegans"
] | [
33
] | 1 | true | Family | Sperm-specific class P | Sperm-specific class P | Sperm-specific_class_P | 5 |
IPR051775 | 51,775 | Homeobox domain-containing protein | Homeobox_domain | Family | 1,189 | true | false | This family of proteins includes transcription factors characterized by a homeobox domain, which is a DNA-binding motif. They are involved in the regulation of gene expression, crucial for various developmental processes. Members of this family are known to bind specific DNA sequences to control the activity of target ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24323"
] | [
"Homeobox_domain"
] | [
1189
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1189
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
1,
3,
1,
2
] | 5 | true | Family | Homeobox domain-containing protein | Homeobox domain-containing protein | Homeobox_domain | 7 |
IPR051776 | 51,776 | Integrator complex subunit 12 | Integrator_subunit_12 | Family | 1,385 | true | false | This family of proteins is involved in the transcription and 3'-box-dependent processing of small nuclear RNAs (snRNAs), including U1 and U2, which are essential for pre-mRNA splicing. Members of this family are components of the Integrator complex, which associates with the C-terminal domain (CTD) of RNA polymerase II... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13415"
] | [
"Integrator_subunit_12"
] | [
1385
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6807505",
"R-DME-6807505",
"R-DRE-6807505",
"R-HSA-6807505",
"R-MMU-6807505",
"R-RNO-6807505",
"R-XTR-6807505"
] | [
"REACTOME:R-BTA-6807505",
"REACTOME:R-DME-6807505",
"REACTOME:R-DRE-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505",
"REACTOME:R-RNO-6807505",
"REACTOME:R-XTR-6807505"
] | 7 | [
"1wev"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1385
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
7,
3,
3
] | 6 | true | Family | Integrator complex subunit 12 | Integrator complex subunit 12 | Integrator_subunit_12 | 8 |
IPR051778 | 51,778 | KH Domain-Containing Protein 1 | KHDC1 | Family | 670 | true | false | The KHDC1 family proteins play a crucial role in DNA replication and repair, particularly in oocytes and early embryonic development. They form the OOEP-KHDC3 scaffold, which is essential for recruiting BLM and TRIM25 to DNA replication forks, promoting BLM ubiquitination and retention, thus aiding in the restart of st... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19447"
] | [
"KHDC1"
] | [
670
] | 1 | [] | [] | [] | 0 | [
"3v69",
"8h93",
"8h94",
"8h95",
"8h96",
"8x7v",
"8x7w",
"8xi3",
"9l4j",
"9l4k",
"9l4l"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
665
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
6
] | 3 | true | Family | KH Domain-Containing Protein 1 | KH Domain-Containing Protein 1 | KHDC1 | 7 |
IPR051779 | 51,779 | Small heat shock protein hspG1-11-like | HspG1-11-like | Family | 61 | true | true | This family of proteins is found in amoeboid protists and is characterised by their role in cellular stress response. There proteins are part of the HSP20 proteins superfamily, including hspG1-11 from Dictyostelium discoideum. Members of this family function as molecular chaperones that can prevent the aggregation of m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46827"
] | [
"sHSP_HSP20"
] | [
61
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
61
] | 1 | [] | [] | 0 | true | Family | Small heat shock protein hspG1-11-like | Small heat shock protein hspG1-11-like | HspG1-11-like | 6 |
IPR051781 | 51,781 | Metallo-dependent Hydrolase Enzymes | Metallo-dep_Hydrolase | Family | 45,873 | true | false | This family of proteins includes enzymes that are part of the metallo-dependent hydrolases superfamily. Members of this family exhibit a range of hydrolytic activities, often involving the cleavage of specific chemical bonds in substrates. Some proteins within this family function as carboxypeptidases, releasing C-term... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43135"
] | [
"Metallo-dep_Hydrolase"
] | [
45873
] | 1 | [] | [] | [] | 0 | [
"2p9b",
"2qs8",
"3be7",
"3dug",
"3feq",
"3mkv",
"3mtw",
"3n2c",
"3ooq",
"4c5y",
"4c5z",
"4c60",
"4c65",
"4ub9",
"4wgx",
"4whb",
"6i5s",
"8ihq",
"8ihr",
"8ihs",
"8j85",
"8yag",
"8yak"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
573,
39591,
5060,
649
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
3,
1
] | 3 | true | Family | Metallo-dependent Hydrolase Enzymes | Metallo-dependent Hydrolase Enzymes | Metallo-dep_Hydrolase | 8 |
IPR051782 | 51,782 | ABC Transporter Superfamily, Various Functions | ABC_Transporter_VariousFunc | Family | 42,071 | true | false | The ABC transporter superfamily is a diverse group of proteins that utilize ATP hydrolysis to translocate a wide variety of substrates across cellular membranes. Members of this family are involved in various biological processes, including the export of bacteriocins, such as SKF and subtilosin, which are antibacterial... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42939"
] | [
"ABC_Transporter_VariousFunc"
] | [
42071
] | 1 | [] | [] | [] | 0 | [
"1sgw",
"4rvc",
"7o0y",
"7o0z",
"7o10",
"7o11",
"7o12",
"7o13",
"7o14",
"7o15",
"7o16",
"7o17",
"7osf",
"7osg",
"7osh",
"7osi",
"7osj",
"7qba",
"7znq"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
1177,
40281,
67,
1,
545
] | 5 | [] | [] | 0 | true | Family | ABC Transporter Superfamily, Various Functions | ABC Transporter Superfamily, Various Functions | ABC_Transporter_VariousFunc | 1 |
IPR051783 | 51,783 | NAD(P)-dependent oxidoreductase-like | NAD(P)-dependent_oxidoreduct | Family | 54,495 | true | true | This family of proteins includes enzymes that are involved in various metabolic processes, including the biosynthesis of sterols, antibiotics, and other bioactive molecules. Members of this family are characterised by their dependence on NAD(P) as a cofactor, performing functions such as oxidative decarboxylation, redu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48079"
] | [
"NAD(P)-dependent_Enzyme"
] | [
54495
] | 1 | [] | [] | [] | 0 | [
"2x4g",
"3gpi",
"3wj7"
] | 3 | [
"PUB00094509",
"PUB00154984",
"PUB00154985"
] | [
"29373009",
"22374809",
"22907798"
] | [
"Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.",
"The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.",
"A semipinacol rear... | [
2018,
2012,
2012
] | 3 | [] | [
"IPR017829"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pseudomonas phage YMC12/01/R24",
"unclassified sequences"
] | [
626,
42807,
10685,
1,
376
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / AT... | [
5,
1,
1,
1,
6,
1,
1,
7
] | 8 | true | Family | NAD(P)-dependent oxidoreductase-like | NAD(P)-dependent oxidoreductase-like | NAD(P)-dependent_oxidoreduct | 7 |
IPR051784 | 51,784 | Nodulation factor ABC transporter | Nod_factor_ABC_transporter | Family | 45,634 | true | false | This family of proteins is involved in the transport of specific bacterial signal molecules known as nodulation factors, which are essential for establishing symbiosis with host plants and triggering nodulation. These factors are lipooligosaccharides, specifically modified beta-1,4-linked N-acetylglucosamine oligosacch... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43229"
] | [
"Nod_factor_ABC_transporter"
] | [
45634
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2113,
42634,
119,
768
] | 4 | [] | [] | 0 | true | Family | Nodulation factor ABC transporter | Nodulation factor ABC transporter | Nod_factor_ABC_transporter | 4 |
IPR051785 | 51,785 | Methylmalonyl-CoA/ethylmalonyl-CoA epimerase | MMCE/EMCE_epimerase | Family | 36,236 | true | false | This family of proteins includes enzymes that are primarily involved in the metabolism of propionyl-CoA and related compounds. Members of this family function as epimerases, catalyzing the reversible epimerization of methylmalonyl-CoA to its isomer. This reaction is a critical step in the degradation pathway of certain... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43048"
] | [
"MMCE/EMCE_epimerase"
] | [
36236
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.1.99.1",
"PWY-5741",
"PWY-5743",
"PWY-5789",
"PWY-6728",
"PWY-7384",
"PWY-7854",
"PWY-8086",
"R-DDI-71032",
"R-HSA-71032",
"R-MMU-71032"
] | [
"EC:5.1.99.1",
"METACYC:PWY-5741",
"METACYC:PWY-5743",
"METACYC:PWY-5789",
"METACYC:PWY-6728",
"METACYC:PWY-7384",
"METACYC:PWY-7854",
"METACYC:PWY-8086",
"REACTOME:R-DDI-71032",
"REACTOME:R-HSA-71032",
"REACTOME:R-MMU-71032"
] | 11 | [
"1jc4",
"1jc5",
"1ss4",
"2qh0",
"3gm5",
"3hdp",
"3oa4",
"3rmu",
"6bu2",
"6qh4",
"6wf6",
"6wf7",
"6wfh",
"6wfi",
"6xbq",
"6xbr",
"6xbs",
"6xbt",
"6xbv"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
1171,
30946,
3392,
1,
726
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
1,
3,
2,
1,
6
] | 6 | true | Family | Methylmalonyl-CoA/ethylmalonyl-CoA epimerase | Methylmalonyl-CoA/ethylmalonyl-CoA epimerase | MMCE/EMCE_epimerase | 9 |
IPR051786 | 51,786 | Asparagine Synthetase/Amidase | ASN_synthetase/amidase | Family | 30,233 | true | false | This family of proteins includes enzymes that are primarily involved in the synthesis of asparagine from aspartate. Members of this family utilize glutamine as a nitrogen source in a two-step reaction, where glutamine is first hydrolyzed to glutamate and ammonia, and then the ammonia is transferred to aspartate to form... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43284"
] | [
"ASN_synthetase/amidase"
] | [
30233
] | 1 | [
"EC"
] | [
"6.3.5.4"
] | [
"EC:6.3.5.4"
] | 1 | [
"7ylz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
548,
27975,
1056,
653,
1
] | 5 | [] | [] | 0 | true | Family | Asparagine Synthetase/Amidase | Asparagine Synthetase/Amidase | ASN_synthetase/amidase | 1 |
IPR051788 | 51,788 | Major Facilitator Superfamily Transporter | MFS_Transporter | Family | 36,303 | true | false | This family of proteins includes members of the major facilitator superfamily (MFS), which are integral membrane transport proteins. They are likely involved in the transport of various substrates across cellular membranes. Some members are probable transporters with specificity for sugars such as glucose and mannose, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23514"
] | [
"MFS_Transporter"
] | [
36303
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
109,
29294,
6448,
452
] | 4 | [
"Escherichia coli (strain K12)",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
1,
2,
1
] | 4 | true | Family | Major Facilitator Superfamily Transporter | Major Facilitator Superfamily Transporter | MFS_Transporter | 6 |
IPR051789 | 51,789 | Bacterial Polyamine Transport Permease | Bact_Polyamine_Transport | Family | 24,016 | true | false | The PotC/PotI protein family is involved in the bacterial transport of polyamines, specifically putrescine and spermidine. Members of this family are integral components of the ABC transporter complex, which is essential for the uptake of these polyamines across the bacterial membrane. The PotC proteins function as par... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43848"
] | [
"Bact_Polyamine_Transport"
] | [
24016
] | 1 | [] | [] | [] | 0 | [
"8y5f",
"8y5g",
"8y5h",
"8y5i",
"8zx1"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
214,
23331,
10,
461
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Bacterial Polyamine Transport Permease | Bacterial Polyamine Transport Permease | Bact_Polyamine_Transport | 4 |
IPR051790 | 51,790 | Cytochrome c-type biogenesis DsbD-related | Cytochrome_c-biogenesis_DsbD | Family | 21,381 | true | false | This family of proteins is involved in the biogenesis of cytochrome c, a component crucial for electron transport and energy production in cells. Members of this family are thought to facilitate the transfer of reducing equivalents, which is essential for the formation of proper disulfide bonds in cytochrome c and othe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31272"
] | [
"Cytochrome_c-biogenesis_DsbD"
] | [
21381
] | 1 | [] | [] | [] | 0 | [
"5vkv"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1003,
18874,
1030,
2,
472
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
4,
8
] | 3 | true | Family | Cytochrome c-type biogenesis DsbD-related | Cytochrome c-type biogenesis DsbD-related | Cytochrome_c-biogenesis_DsbD | 1 |
IPR051791 | 51,791 | Proline-rich immunoreactive protein | Pra-immunoreactive | Family | 24,910 | true | false | This family of proteins includes members that are homologous to the mycobacterial Pra family, which are characterized by proline-rich regions. These regions are known to be immunoreactive, suggesting a role in immune response or interaction with the host immune system. The exact functions of the uncharacterized protein... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36115"
] | [
"Pra-immunoreactive"
] | [
24910
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
205,
24332,
24,
349
] | 4 | [] | [] | 0 | true | Family | Proline-rich immunoreactive protein | Proline-rich immunoreactive protein | Pra-immunoreactive | 3 |
IPR051792 | 51,792 | Gamma-glutamyltransferase, bacteria | GGT_bact | Family | 20,091 | true | true | This family of proteins includes enzymes that play a role in the metabolism of glutathione and related gamma-glutamyl compounds. Members of this family are involved in the cleavage of the gamma-glutamyl bond of glutathione, which leads to the release of free glutamate and the dipeptide cysteinyl-glycine. This process i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43199"
] | [
"GGT-related_enzyme"
] | [
20091
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.2.2",
"3.4.19.13",
"PWY-4041",
"PWY-4061",
"PWY-5826",
"PWY-6842",
"PWY-7112",
"PWY-7559",
"PWY-8001",
"PWY-8301",
"PWY-8355"
] | [
"EC:2.3.2.2",
"EC:3.4.19.13",
"METACYC:PWY-4041",
"METACYC:PWY-4061",
"METACYC:PWY-5826",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7559",
"METACYC:PWY-8001",
"METACYC:PWY-8301",
"METACYC:PWY-8355"
] | 11 | [
"2dbu",
"2dbw",
"2dbx",
"2dg5",
"2e0w",
"2e0x",
"2e0y",
"2nqo",
"2qm6",
"2qmc",
"2v36",
"2z8i",
"2z8j",
"2z8k",
"3a75",
"3fnm",
"3g9k",
"3ga9",
"3whq",
"3whr",
"3whs",
"4ott",
"4otu",
"4y23",
"5b5t",
"5bpk",
"5xlu",
"5y8x",
"5y9b",
"5zjg",
"7d9e",
"7d9w"... | 33 | [] | [] | [] | [] | 0 | [
"IPR000101"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
65,
19530,
92,
404
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Gamma-glutamyltransferase, bacteria | Gamma-glutamyltransferase, bacteria | GGT_bact | 5 |
IPR051793 | 51,793 | NADH:flavin oxidoreductase/NADH oxidase | NADH:flavin_oxidoreductase | Family | 20,213 | true | true | This family of proteins includes various NADH:flavin oxidoreductases and NADH oxidases. Members of this family are involved in a range of redox reactions, often utilizing NADH or NADPH as electron donors to reduce flavin or other substrates. They play roles in metabolic processes such as the beta-oxidation of unsaturat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42917"
] | [
"NADH:flavin_oxidoreductase"
] | [
20213
] | 1 | [] | [] | [] | 0 | [
"1djn",
"1djq",
"1o94",
"1o95",
"1ps9",
"2tmd",
"3k30",
"6de6",
"6l6j",
"6qkg",
"6qkr",
"6qkx"
] | 12 | [
"PUB00154536",
"PUB00154537"
] | [
"18047844",
"38172624"
] | [
"Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.",
"BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen."
] | [
2008,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
119,
19274,
360,
460
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | NADH:flavin oxidoreductase/NADH oxidase | NADH:flavin oxidoreductase/NADH oxidase | NADH:flavin_oxidoreductase | 8 |
IPR051794 | 51,794 | Peptidoglycan endopeptidase RipA/RipB-like | RipA/RipB-like | Family | 24,559 | true | true | This family of proteins includes endopeptidases that play a role in bacterial cell wall metabolism. Members of this family are involved in the cleavage of peptidoglycan, specifically breaking the bond between D-glutamate and meso-diaminopimelate. This enzymatic activity is crucial for the proper separation of daughter ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47359"
] | [
"PG_Endopeptidase_C40"
] | [
24559
] | 1 | [] | [] | [] | 0 | [
"2xiv",
"3gt2",
"3i86",
"3ne0",
"3pbc",
"3pbi",
"3s0q",
"4jxb",
"4lj1",
"4q4g",
"4q4n",
"4q4t",
"6b8c",
"6bim",
"6bio",
"6biq",
"8auc",
"8aud",
"8er5",
"8ev4",
"8ev5",
"8idc",
"8idd",
"8igq",
"8jia"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Viruses",
"metagenomes"
] | [
23914,
371,
3,
99,
172
] | 5 | [] | [] | 0 | true | Family | Peptidoglycan endopeptidase RipA/RipB-like | Peptidoglycan endopeptidase RipA/RipB-like | RipA/RipB-like | 4 |
IPR051795 | 51,795 | Glycosyl Hydrolase Family 43 | Glycosyl_Hydrlase_43 | Family | 24,982 | true | false | The glycosyl hydrolase 43 family encompasses enzymes with diverse functions primarily involved in the degradation of complex carbohydrates. Members of this family include alpha-L-arabinofuranosidases and beta-xylosidases, which act on non-reducing ends of their respective substrates. Alpha-L-arabinofuranosidases cleave... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42812"
] | [
"Glycosyl_Hydrlase_43"
] | [
24982
] | 1 | [
"EC",
"METACYC"
] | [
"3.2.1.37",
"PWY-6717"
] | [
"EC:3.2.1.37",
"METACYC:PWY-6717"
] | 2 | [
"1y7b",
"1yi7",
"1yif",
"1yrz",
"2exh",
"2exi",
"2exj",
"2exk",
"3c2u",
"3zxj",
"3zxk",
"3zxl",
"5jow",
"5jox",
"5joy",
"5joz",
"5z5d",
"5z5f",
"5z5h",
"5z5i",
"5zqj",
"5zqs",
"5zqx",
"6ife",
"6mly",
"6ms2",
"6ms3",
"7erl",
"7jvh",
"7k1r",
"8uws",
"9he8"... | 32 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
18174,
6662,
38,
108
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
2
] | 2 | true | Family | Glycosyl Hydrolase Family 43 | Glycosyl Hydrolase Family 43 | Glycosyl_Hydrlase_43 | 6 |
IPR051796 | 51,796 | Iron-sulfur flavoprotein SsuE-like | ISF_SsuE-like | Family | 13,907 | true | false | This family of proteins includes redox-active components likely involved in electron transport processes. Members are characterized by the presence of iron-sulfur clusters and flavin mononucleotide (FMN) as cofactors, which are indicative of their roles in various electron transfer reactions. These proteins are implica... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43278"
] | [
"ISF_SsuE-like"
] | [
13907
] | 1 | [] | [] | [] | 0 | [
"1rli",
"1sqs",
"2oys",
"7d38",
"7d39",
"7d3a",
"7d3b"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctgXL3",
"unclassified sequences"
] | [
1703,
11673,
154,
1,
376
] | 5 | [] | [] | 0 | true | Family | Iron-sulfur flavoprotein SsuE-like | Iron-sulfur flavoprotein SsuE-like | ISF_SsuE-like | 4 |
IPR051797 | 51,797 | Transcription regulator TrmB-like | TrmB-like | Family | 16,397 | true | true | This family of proteins includes prokaryotic transcriptional regulators that interact with DNA to modulate gene expression in response to sugar availability, such as HTH-type sugar sensing transcriptional regulator TrmB from the hyperthermophilic archaea Pyrococcus furiosus, which contains an N-terminal DNA-binding dom... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34293"
] | [
"HTH_sugar_sensing_regulator"
] | [
16397
] | 1 | [] | [] | [] | 0 | [
"3qph",
"5box",
"5bpd",
"5bpi",
"5bqt"
] | 5 | [
"PUB00040546",
"PUB00158905"
] | [
"16473881",
"23576322"
] | [
"Crystal structure of the sugar binding domain of the archaeal transcriptional regulator TrmB.",
"The three-dimensional structure of TrmB, a transcriptional regulator of dual function in the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose."
] | [
2006,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Phytophthora kernoviae 00238/432",
"Streptomyces phage Chymera",
"unclassified sequences"
] | [
3708,
12575,
1,
1,
112
] | 5 | [] | [] | 0 | true | Family | Transcription regulator TrmB-like | Transcription regulator TrmB-like | TrmB-like | 2 |
IPR051798 | 51,798 | Class-II Pyridoxal-Phosphate-Dependent Aminotransferase | Class-II_PLP-Dep_Aminotrans | Family | 18,061 | true | false | This family of proteins includes enzymes that are primarily involved in the metabolism of sulfur-containing amino acids. Members of this family catalyze the transformation of cystathionine to homocysteine, a key step in the methionine biosynthesis pathway. Some proteins within this family also exhibit beta-cystathionas... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43525"
] | [
"Class-II_PLP-Dep_Aminotrans"
] | [
18061
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.4.1.13",
"PWY-1187",
"PWY-2821",
"PWY-601",
"PWY-6842",
"PWY-6936",
"PWY-7901",
"PWY-801",
"PWY-8302"
] | [
"EC:4.4.1.13",
"METACYC:PWY-1187",
"METACYC:PWY-2821",
"METACYC:PWY-601",
"METACYC:PWY-6842",
"METACYC:PWY-6936",
"METACYC:PWY-7901",
"METACYC:PWY-801",
"METACYC:PWY-8302"
] | 9 | [
"1c7n",
"1c7o",
"1d2f",
"3b1c",
"3b1d",
"3b1e",
"3dzz",
"3fdb",
"3l8a",
"3t32",
"4dgt",
"4dq6",
"5z0q",
"6qp1",
"6qp2",
"6qp3",
"7qug",
"8bob",
"8juj",
"8y54",
"9jva",
"9jwc",
"9k71",
"9kau",
"9m0q"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
32,
17604,
102,
323
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Class-II Pyridoxal-Phosphate-Dependent Aminotransferase | Class-II Pyridoxal-Phosphate-Dependent Aminotransferase | Class-II_PLP-Dep_Aminotrans | 9 |
IPR051800 | 51,800 | Intermembrane Transport Protein PqiA/PqiB | PqiA-PqiB_transport | Family | 18,050 | true | false | The PqiA/PqiB family includes intermembrane transport proteins that play a crucial role in maintaining membrane integrity. Members of the family are involved in a transport pathway that likely spans the intermembrane space, facilitating the movement of substrates across the periplasm. The proteins are probable componen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30462"
] | [
"PqiA-PqiB_transport"
] | [
18050
] | 1 | [] | [] | [] | 0 | [
"5uvn",
"6kz3",
"6kz4",
"6v0c",
"6v0d",
"6v0e",
"6v0f",
"6v0g",
"6v0h",
"6v0i",
"6v0j",
"6vci",
"7see",
"7sef",
"9n8w",
"9n8x"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctT1Q6",
"metagenomes"
] | [
17964,
16,
1,
69
] | 4 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Family | Intermembrane Transport Protein PqiA/PqiB | Intermembrane Transport Protein PqiA/PqiB | PqiA-PqiB_transport | 4 |
IPR051801 | 51,801 | Glycosyl_Hydrolase_28_Enzymes | GH28_Enzymes | Family | 20,283 | true | false | This family of proteins includes enzymes that are part of the glycosyl hydrolase 28 family. They are involved in the degradation of pectin, a plant cell wall polysaccharide, by catalyzing the hydrolysis of polygalacturonic acid. Members of this family contribute to various biological processes, including plant tissue m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31339"
] | [
"GH28_Enzymes"
] | [
20283
] | 1 | [
"EC"
] | [
"3.2.1.15"
] | [
"EC:3.2.1.15"
] | 1 | [
"1bhe",
"2uve",
"2uvf",
"3jur",
"3zpp",
"4mr0",
"4mxn",
"5olp"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
88,
11348,
5,
8745,
97
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
77,
40,
78
] | 3 | true | Family | Glycosyl_Hydrolase_28_Enzymes | Glycosyl_Hydrolase_28_Enzymes | GH28_Enzymes | 6 |
IPR051802 | 51,802 | Alpha-2-macroglobulin-like | YfhM-like | Family | 13,645 | true | true | This family of proteins includes Alpha-2-macroglobulin from Escherichia coli (YfhM) and similar proteins mainly found in bacteria. These proteins serve a protective role for the cell. They act as protease inhibitors, safeguarding the bacterial cell from host-derived peptidases [ , , ]. These proteins employ a 'trapping... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40094"
] | [
"Bacterial_a2-macroglobulin"
] | [
13645
] | 1 | [] | [] | [] | 0 | [
"4rtd",
"4u48",
"4u4j",
"4u59",
"4ziq",
"4ziu",
"4zjg",
"4zjh",
"5a42"
] | 9 | [
"PUB00103798",
"PUB00151710",
"PUB00155205",
"PUB00155206"
] | [
"26100869",
"26143919",
"18510733",
"18697741"
] | [
"Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.",
"Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.",
"cpRAS: a novel circularly permuted RAS-like GTP... | [
2015,
2015,
2008,
2008
] | 4 | [] | [
"IPR026284"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Halorubrum tibetense",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
13045,
405,
1,
1,
193
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Alpha-2-macroglobulin-like | Alpha-2-macroglobulin-like | YfhM-like | 1 |
IPR051803 | 51,803 | Type II TA system RelE-like toxin | TA_system_RelE-like_toxin | Family | 12,659 | true | false | This family of proteins includes toxic components of type II toxin-antitoxin (TA) systems. These toxins can inhibit cell growth and colony formation when expressed in bacteria such as E. coli. Their toxic effects are specifically neutralized by coexpression with their cognate antitoxins. In some cases, low levels of th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33755"
] | [
"TA_system_RelE-like_toxin"
] | [
12659
] | 1 | [] | [] | [] | 0 | [
"3kxe",
"5ceg",
"5cw7",
"5cze",
"5czf",
"6x0a",
"6xrw",
"7etr",
"7r5a",
"7ycs",
"7ycu",
"8c24",
"8c26"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Protostomia",
"plasmids",
"unclassified sequences"
] | [
4,
12392,
2,
4,
257
] | 5 | [] | [] | 0 | true | Family | Type II TA system RelE-like toxin | Type II TA system RelE-like toxin | TA_system_RelE-like_toxin | 2 |
IPR051804 | 51,804 | Carbohydrate Metabolism Regulated Kinase/Isomerase | Carb_Metab_Reg_Kinase/Isom | Family | 13,877 | true | false | This family of proteins includes enzymes that are involved in carbohydrate metabolism. Members of this family are known to participate in the degradation of glucomannan, a polysaccharide composed of glucose and mannose. Some proteins in this family function as fructokinases, which are enzymes that phosphorylate fructos... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42742"
] | [
"Carb_Metab_Reg_Kinase/Isom"
] | [
13877
] | 1 | [] | [] | [] | 0 | [
"1qwr",
"1xc3",
"3lm9",
"3ohr"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pithovirus LCPAC404",
"metagenomes"
] | [
20,
13280,
408,
1,
168
] | 5 | [] | [] | 0 | true | Family | Carbohydrate Metabolism Regulated Kinase/Isomerase | Carbohydrate Metabolism Regulated Kinase/Isomerase | Carb_Metab_Reg_Kinase/Isom | 4 |
IPR051805 | 51,805 | Dehydratase Activator and Reductase Protein | Dehydratase_Activator_Redct | Family | 11,129 | true | false | This family of proteins includes activators of various dehydratase enzymes and reductases involved in anaerobic fermentation pathways. Members of this family are responsible for activating dehydratase complexes through ATP-dependent electron transfer, which is crucial for maintaining an appropriate redox state of the d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32329"
] | [
"Dehydratase_Activator_Redct"
] | [
11129
] | 1 | [] | [] | [] | 0 | [
"1hux",
"4eht",
"4ehu",
"4eia",
"7yyl",
"7yzm",
"7yzq"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Metamonada",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
375,
9976,
41,
2,
735
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Dehydratase Activator and Reductase Protein | Dehydratase Activator and Reductase Protein | Dehydratase_Activator_Redct | 9 |
IPR051806 | 51,806 | HAD-like Sugar Phosphate Phosphatase | HAD-like_SPP | Family | 17,929 | true | false | This family of proteins includes phosphatases that are part of the HAD-like hydrolase superfamily. Members of this family are involved in various metabolic processes, including glycerol biosynthesis, osmoadaptation, and the dephosphorylation of a range of sugar phosphates. Some proteins in this family contribute to cel... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43481"
] | [
"HAD-like_SPP"
] | [
17929
] | 1 | [] | [] | [] | 0 | [
"2qlt",
"3dv9",
"3qu2",
"3qu4",
"3qu5",
"3qu7",
"3qu9",
"3qub",
"3quc",
"3quq",
"3qut",
"3qx7",
"3qxg",
"3qyp",
"3r9k",
"3s6j"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Peduovirus P24C9",
"metagenomes"
] | [
181,
14841,
2746,
1,
160
] | 5 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1,
4
] | 3 | true | Family | HAD-like Sugar Phosphate Phosphatase | HAD-like Sugar Phosphate Phosphatase | HAD-like_SPP | 1 |
IPR051807 | 51,807 | Secondary metabolite biosynthesis-associated protein | Sec-metab_biosynth-assoc | Family | 13,186 | true | false | This family of proteins is involved in the biosynthesis of various secondary metabolites, including mycotoxins, linear lipopeptides, antibiotics, and meroterpenoids. They are implicated in the activation and processing of amino acid precursors, the formation of polyketides, and the assembly of nonribosomal peptide synt... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33606"
] | [
"Sec-metab_biosynth-assoc"
] | [
13186
] | 1 | [] | [] | [] | 0 | [
"1mwq",
"4lbh",
"4lbi",
"4lbp"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10389,
2698,
99
] | 3 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Family | Secondary metabolite biosynthesis-associated protein | Secondary metabolite biosynthesis-associated protein | Sec-metab_biosynth-assoc | 2 |
IPR051808 | 51,808 | Type IV pilus biogenesis and competence protein | Type_IV_pilus_biogenesis | Family | 7,963 | true | false | This family of proteins includes components involved in the biogenesis and function of type IV pili, which are filamentous structures on bacterial cell surfaces. These proteins are essential for pilus assembly, serving as a gateway for the pilus to traverse the outer membrane. Additionally, they are implicated in bacte... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30604"
] | [
"Type_IV_pilus_biogenesis"
] | [
7963
] | 1 | [] | [] | [] | 0 | [
"2y3m",
"3jc8",
"3jc9",
"4aqz",
"4ar0",
"4av2",
"6ve2",
"6ve3",
"6ve4",
"6w6m"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pseudomonas phage Pf3",
"environmental samples",
"unclassified sequences"
] | [
7761,
20,
1,
2,
179
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type IV pilus biogenesis and competence protein | Type IV pilus biogenesis and competence protein | Type_IV_pilus_biogenesis | 8 |
IPR051809 | 51,809 | Plant receptor-like serine/threonine-protein kinase | Plant_receptor-like_S/T_kinase | Family | 14,172 | true | false | This family of proteins includes receptor-like serine/threonine-protein kinases that play crucial roles in plant immunity and development. They are involved in the perception of pathogen-associated molecular patterns (PAMPs) and endogenous elicitors, triggering immune responses. Some members are responsible for the det... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR27008"
] | [
"Plant_receptor-like_S/T_kinase"
] | [
14172
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
9,
14161,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
30,
140,
72
] | 3 | true | Family | Plant receptor-like serine/threonine-protein kinase | Plant receptor-like serine/threonine-protein kinase | Plant_receptor-like_S/T_kinase | 1 |
IPR051810 | 51,810 | Precorrin Methyltransferase | Precorrin_MeTrfase | Family | 11,828 | true | false | The precorrin methyltransferase family is involved in the biosynthesis of cobalamin (vitamin B12). Members of this family are responsible for various methylation steps in the transformation of precorrin-2 into different intermediates leading towards the final cobalamin structure. These enzymes catalyze the methylation ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47036"
] | [
"Precorrin_MeTrfase"
] | [
11828
] | 1 | [
"EC"
] | [
"2.1.1"
] | [
"EC:2.1.1"
] | 1 | [
"2zvb",
"2zvc",
"3nut"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
871,
10821,
13,
123
] | 4 | [] | [] | 0 | true | Family | Precorrin Methyltransferase | Precorrin Methyltransferase | Precorrin_MeTrfase | 8 |
IPR051811 | 51,811 | Cytochrome c550/c551-like | Cytochrome_c550/c551-like | Family | 8,871 | true | true | The cytochrome c family is involved in various electron transfer processes within cells. Members of this family serve as electron carriers or as components of larger enzyme complexes that participate in respiratory and metabolic pathways. For instance, some cytochromes c are essential for organisms to utilize specific ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37823"
] | [
"Cytochrome_c_ET"
] | [
8871
] | 1 | [] | [] | [] | 0 | [
"1b7v",
"1c75",
"1k3g",
"1k3h",
"1n9c",
"3o0r",
"3wfb",
"3wfc",
"3wfd",
"3wfe",
"5guw",
"5gux"
] | 12 | [
"PUB00015936",
"PUB00074339"
] | [
"7592464",
"10075429"
] | [
"The cytochrome bc complex (menaquinone:cytochrome c reductase) in Bacillus subtilis has a nontraditional subunit organization.",
"Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an a... | [
1995,
1999
] | 2 | [] | [
"IPR012049",
"IPR012218",
"IPR030991"
] | 0 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
8747,
4,
3,
117
] | 4 | [] | [] | 0 | true | Family | Cytochrome c550/c551-like | Cytochrome c550/c551-like | Cytochrome_c550/c551-like | 7 |
IPR051812 | 51,812 | Sugar Phosphate Isomerase LacAB/RpiB | SPI_LacAB/RpiB | Family | 7,974 | true | false | This family of proteins includes enzymes that are involved in the isomerization of sugar phosphates, which is a critical step in various metabolic pathways. Members of this family catalyze the conversion of D-erythrulose 4-phosphate to D-erythrose 4-phosphate, a reaction that is part of the catabolism of D-apiose and o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43732"
] | [
"SPI_LacAB/RpiB"
] | [
7974
] | 1 | [] | [] | [] | 0 | [
"1nn4",
"2vvr",
"3he8",
"3hee",
"3ph3",
"3ph4",
"3qd5",
"3sdw",
"3sgw",
"5ifz",
"6fxw"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured marine group II/III euryarchaeote AD1000_35_F01"
] | [
6729,
1147,
97,
1
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Family | Sugar Phosphate Isomerase LacAB/RpiB | Sugar Phosphate Isomerase LacAB/RpiB | SPI_LacAB/RpiB | 6 |
IPR051814 | 51,814 | NAD(P)H-dependent FMN reductase | NAD(P)H-dep_FMN_reductase | Family | 12,359 | true | false | This family of proteins includes NAD(P)H-dependent flavin mononucleotide (FMN) reductases that are involved in various biological processes, including the degradation of dimethyl sulfide and tryptophan. Members of this family catalyze the reduction of FMN to FMNH2, using NADH or NADPH as electron donors. Some proteins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43408"
] | [
"NAD(P)H-dep_FMN_reductase"
] | [
12359
] | 1 | [
"EC"
] | [
"1.5.1"
] | [
"EC:1.5.1"
] | 1 | [
"3k1y",
"3k20",
"4c76",
"4ltd",
"4ltm",
"4ltn",
"4pty",
"4ptz",
"4pu0",
"6dqi",
"6dqo",
"6dqp",
"7qw4"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
108,
12182,
21,
48
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | NAD(P)H-dependent FMN reductase | NAD(P)H-dependent FMN reductase | NAD(P)H-dep_FMN_reductase | 9 |
IPR051815 | 51,815 | Molybdate-responsive transcriptional regulator | Molybdate_resp_trans_reg | Family | 10,528 | true | false | This family of proteins includes transcriptional regulators that interact with molybdate. They function as sensors and regulators of molybdate transport and metabolism within the cell. Upon molybdate binding, these proteins undergo conformational changes that facilitate dimerization. The resulting dimer is capable of b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30432"
] | [
"Molybdate_resp_trans_reg"
] | [
10528
] | 1 | [] | [] | [] | 0 | [
"1b9m",
"1b9n",
"1h9j",
"1h9k",
"1h9m",
"1h9r",
"1h9s",
"1o7l",
"2ijl"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Sym plasmid",
"unclassified sequences"
] | [
529,
9890,
3,
1,
105
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Molybdate-responsive transcriptional regulator | Molybdate-responsive transcriptional regulator | Molybdate_resp_trans_reg | 6 |
IPR051816 | 51,816 | Glycosyl Hydrolase Family 31 | Glycosyl_Hydrolase_31 | Family | 11,704 | true | false | The glycosyl hydrolase 31 family is involved in the degradation of various oligosaccharides. Members of this family catalyze the hydrolysis of glycosidic bonds, specifically liberating alpha-xylose from the non-reducing terminal glucose of xyloglucan oligosaccharides, which is crucial in xyloglucan degradation. Some en... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43863"
] | [
"Glycosyl_Hydrolase_31"
] | [
11704
] | 1 | [] | [] | [] | 0 | [
"2xvg",
"2xvk",
"2xvl",
"4kmq",
"4kwu",
"5f7s",
"5f7u",
"5hpo",
"5hxm",
"5i0d",
"5i0e",
"5i0f",
"5i0g",
"5jou",
"5jov",
"5x3i",
"5x3j",
"5x3k",
"5x7o",
"5x7p",
"5x7q",
"5x7r",
"5x7s",
"5zn6",
"5zn7",
"6dru",
"7kmp",
"7knc",
"7wj9",
"7wja",
"7wjb",
"7wjc"... | 36 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
92,
9616,
1875,
121
] | 4 | [
"Homo sapiens",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | Glycosyl Hydrolase Family 31 | Glycosyl Hydrolase Family 31 | Glycosyl_Hydrolase_31 | 3 |
IPR051817 | 51,817 | Formate dehydrogenase cytochrome b556 subunit | FDH_cytochrome_b556_subunit | Family | 8,500 | true | false | This family of proteins includes subunits of formate dehydrogenases, which are enzymes that allow bacteria to use formate as a major electron donor in various types of respiration. Some members are involved in aerobic respiration, while others participate in anaerobic respiration, using nitrate as an electron acceptor.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30074"
] | [
"FDH_cytochrome_b556_subunit"
] | [
8500
] | 1 | [] | [] | [] | 0 | [
"1kqf",
"1kqg"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
18,
8405,
6,
71
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Formate dehydrogenase cytochrome b556 subunit | Formate dehydrogenase cytochrome b556 subunit | FDH_cytochrome_b556_subunit | 9 |
IPR051818 | 51,818 | Thiamine pyrophosphate-dependent decarboxylase | TPP_dependent_decarboxylase | Family | 4,929 | true | false | The TPP enzyme family is involved in the biosynthesis of small molecule compounds through the decarboxylation of specific substrates. Members of this family catalyze the decarboxylation of sulfopyruvate to sulfoacetaldehyde, which is a step in the biosynthesis of coenzyme M (2-mercaptoethanesulfonic acid). Additionally... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42818"
] | [
"TPP_dependent_decarboxylase"
] | [
4929
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"4.1.1.79",
"PWY-6637",
"PWY-6643"
] | [
"EC:4.1.1.79",
"METACYC:PWY-6637",
"METACYC:PWY-6643"
] | 3 | [
"9iz3",
"9iz4"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
406,
3866,
408,
249
] | 4 | [] | [] | 0 | true | Family | Thiamine pyrophosphate-dependent decarboxylase | Thiamine pyrophosphate-dependent decarboxylase | TPP_dependent_decarboxylase | 3 |
IPR051819 | 51,819 | PTS system sugar-specific EIIB domain-containing protein | PTS_sugar-specific_EIIB | Family | 9,822 | true | false | This family of proteins is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which is a major carbohydrate active transport system. These proteins function by catalyzing the phosphorylation of incoming sugar substrates simultaneously with their translocation across the cell membrane. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34581"
] | [
"PTS_sugar-specific_EIIB"
] | [
9822
] | 1 | [
"EC"
] | [
"2.7.1"
] | [
"EC:2.7.1"
] | 1 | [
"1e2b",
"1h9c",
"1iib",
"2l2q",
"2wwv",
"2wy2",
"4mge"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
9795,
4,
23
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | PTS system sugar-specific EIIB domain-containing protein | PTS system sugar-specific EIIB domain-containing protein | PTS_sugar-specific_EIIB | 9 |
IPR051820 | 51,820 | FAD-containing monooxygenase EthA-like | EthA-like | Family | 7,813 | true | true | This family of proteins includes FAD-binding monooxygenases that are involved in various oxidative reactions. Members of this family catalyze Baeyer-Villiger oxidation reactions, converting ketones into esters or lactones, and are capable of acting on a range of substrates from long-chain aliphatic ketones to aromatic ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43872"
] | [
"FAD-binding_MO"
] | [
7813
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.14.13.-",
"PWY-1381",
"PWY-2421",
"PWY-2467",
"PWY-2724",
"PWY-321",
"PWY-5317",
"PWY-5318",
"PWY-5412",
"PWY-5413",
"PWY-5414",
"PWY-5421",
"PWY-5422",
"PWY-5434",
"PWY-5706",
"PWY-581",
"PWY-5846",
"PWY-5855",
"PWY-5856",
"PWY-5857",
"PWY-5870",
"PWY-5871",
"PWY-5872... | [
"EC:1.14.13.-",
"METACYC:PWY-1381",
"METACYC:PWY-2421",
"METACYC:PWY-2467",
"METACYC:PWY-2724",
"METACYC:PWY-321",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-5412",
"METACYC:PWY-5413",
"METACYC:PWY-5414",
"METACYC:PWY-5421",
"METACYC:PWY-5422",
"METACYC:PWY-5434",
"METACYC:PWY-... | 117 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5692,
2010,
111
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | FAD-containing monooxygenase EthA-like | FAD-containing monooxygenase EthA-like | EthA-like | 6 |
IPR051821 | 51,821 | Aspartyl/Asparaginyl beta-hydroxylase domain-containing protein | Asp/Asn_beta-hydroxylase | Family | 7,907 | true | false | This family of proteins includes enzymes that may function as 2-oxoglutarate-dependent dioxygenases. These enzymes are involved in various biological processes, including the hydroxylation of specific residues in proteins, which can affect protein stability, localization, and interaction with other molecules. Some fami... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46332"
] | [
"Asp/Asn_beta-hydroxylase"
] | [
7907
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.14.11.-",
"PWY-102",
"PWY-1187",
"PWY-5035",
"PWY-5036",
"PWY-5047",
"PWY-5070",
"PWY-5349",
"PWY-6085",
"PWY-6086",
"PWY-6495",
"PWY-6682",
"PWY-6915",
"PWY-6919",
"PWY-7150",
"PWY-7151",
"PWY-7232",
"PWY-7274",
"PWY-7298",
"PWY-7398",
"PWY-7419",
"PWY-7517",
"PWY-764... | [
"EC:1.14.11.-",
"METACYC:PWY-102",
"METACYC:PWY-1187",
"METACYC:PWY-5035",
"METACYC:PWY-5036",
"METACYC:PWY-5047",
"METACYC:PWY-5070",
"METACYC:PWY-5349",
"METACYC:PWY-6085",
"METACYC:PWY-6086",
"METACYC:PWY-6495",
"METACYC:PWY-6682",
"METACYC:PWY-6915",
"METACYC:PWY-6919",
"METACYC:PWY-... | 35 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5431,
2379,
41,
56
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
6,
6
] | 4 | true | Family | Aspartyl/Asparaginyl beta-hydroxylase domain-containing protein | Aspartyl/Asparaginyl beta-hydroxylase domain-containing protein | Asp/Asn_beta-hydroxylase | 7 |
IPR051822 | 51,822 | Glycosyl Hydrolase Family 84 | Glycosyl_Hydrolase_84 | Family | 8,677 | true | false | The glycosyl hydrolase 84 family is characterized by its ability to cleave N-acetylglucosamine (GlcNAc) from O-glycosylated proteins. Members of this family can utilize substrates such as p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc in vitro, but do not act on p-nitrophenyl-beta-GalNAc or p-nitrophenyl-al... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13170"
] | [
"Glycosyl_Hydrolase_84"
] | [
8677
] | 1 | [
"EC",
"METACYC"
] | [
"3.2.1.169",
"PWY-7437"
] | [
"EC:3.2.1.169",
"METACYC:PWY-7437"
] | 2 | [
"2cbi",
"2cbj",
"2chn",
"2cho",
"2j47",
"2j4g",
"2j62",
"2jiw",
"2v5c",
"2v5d",
"2vur",
"2vvn",
"2vvs",
"2w4x",
"2w66",
"2w67",
"2wb5",
"2wca",
"2wzh",
"2wzi",
"2x0h",
"2x0y",
"2xj7",
"2xm1",
"2xm2",
"2xpk",
"2xsa",
"2xsb",
"2ydq",
"2ydr",
"2yds",
"3zj0"... | 85 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoproteota",
"unclassified sequences"
] | [
4500,
4084,
4,
89
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
2,
4,
5,
7
] | 6 | true | Family | Glycosyl Hydrolase Family 84 | Glycosyl Hydrolase Family 84 | Glycosyl_Hydrolase_84 | 7 |
IPR051823 | 51,823 | Aspartate-semialdehyde dehydrogenase-related | ASADH-related | Family | 4,655 | true | false | This family of proteins includes enzymes that are primarily involved in the biosynthesis of amino acids through catalytic activities. Members of this family are known to catalyze the NADPH-dependent formation of L-aspartate-semialdehyde from L-aspartyl-4-phosphate, a critical step in the biosynthetic pathway leading to... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46718"
] | [
"ASADH-related"
] | [
4655
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.11",
"PWY-2941",
"PWY-2942",
"PWY-5097",
"PWY-6160",
"PWY-6559",
"PWY-6562",
"PWY-7153",
"PWY-7977",
"PWY-8088",
"PWY-8179",
"PWY-8296"
] | [
"EC:1.2.1.11",
"METACYC:PWY-2941",
"METACYC:PWY-2942",
"METACYC:PWY-5097",
"METACYC:PWY-6160",
"METACYC:PWY-6559",
"METACYC:PWY-6562",
"METACYC:PWY-7153",
"METACYC:PWY-7977",
"METACYC:PWY-8088",
"METACYC:PWY-8179",
"METACYC:PWY-8296"
] | 12 | [
"1ys4",
"2ep5",
"3hsk",
"4dpk",
"4dpl",
"4dpm",
"4zhs",
"4zic",
"5cef",
"5jw6",
"6c85",
"6c8w"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
874,
1835,
1864,
82
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Aspartate-semialdehyde dehydrogenase-related | Aspartate-semialdehyde dehydrogenase-related | ASADH-related | 7 |
IPR051824 | 51,824 | LRR Receptor-Like Ser/Thr Protein Kinase | LRR_Rcpt-Like_S/T_Kinase | Family | 27,305 | true | false | This family of proteins includes receptor-like serine/threonine-protein kinases with leucine-rich repeat (LRR) domains. These kinases are part of the protein kinase superfamily and play a crucial role in signal transduction pathways. They are involved in various cellular processes, including growth, differentiation, an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48006"
] | [
"LRR_Rcpt-Like_S/T_Kinase"
] | [
27305
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-CEL-9020702",
"R-HSA-1257604",
"R-HSA-166058",
"R-HSA-5603037",
"R-HSA-5603041",
"R-HSA-6811558",
"R-HSA-9020702",
"R-HSA-975110",
"R-HSA-975138",
"R-HSA-975155",
"R-HSA-975871",
"R-MMU-1257604",
"R-MMU-6811558",
"R-MMU-9020702"
] | [
"EC:2.7.11.1",
"REACTOME:R-CEL-9020702",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-5603037",
"REACTOME:R-HSA-5603041",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-9020702",
"REACTOME:R-HSA-975110",
"REACTOME:R-HSA-975138",
"REACTOME:R-HSA-975155",
"REACTOME:R-HSA-975871"... | 15 | [
"2nru",
"2nry",
"2o8y",
"2oib",
"2oic",
"2oid",
"3tl8",
"3uim",
"3ulz",
"4l68",
"4rmz",
"4u97",
"4u9a",
"4xs2",
"4y73",
"4yo6",
"4yp8",
"4ztl",
"4ztm",
"4ztn",
"5k72",
"5k75",
"5k76",
"5k7g",
"5k7i",
"5kx7",
"5kx8",
"5t1s",
"5t1t",
"5uiq",
"5uir",
"5uis"... | 98 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
27296
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
166,
1,
4,
2,
147,
2,
193
] | 7 | true | Family | LRR Receptor-Like Ser/Thr Protein Kinase | LRR Receptor-Like Ser/Thr Protein Kinase | LRR_Rcpt-Like_S/T_Kinase | 5 |
IPR051826 | 51,826 | E3 ubiquitin-protein ligase domain-containing protein | E3_ubiquitin-ligase_domain | Family | 5,922 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that are involved in various cellular processes, including the regulation of cell proliferation and apoptosis. They play a role in mediating ubiquitination and subsequent proteasomal degradation of specific target proteins. Some members are involved in the n... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22765"
] | [
"E3_ubiquitin-ligase_domain"
] | [
5922
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lentzea aerocolonigenes",
"Viruses",
"metagenomes"
] | [
5890,
2,
10,
20
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
1,
2,
3,
20,
17
] | 6 | true | Family | E3 ubiquitin-protein ligase domain-containing protein | E3 ubiquitin-protein ligase domain-containing protein | E3_ubiquitin-ligase_domain | 3 |
IPR051827 | 51,827 | CRISPR-associated exonuclease Cas4 | Cas4_exonuclease | Family | 4,506 | true | false | The CRISPR-associated exonuclease Cas4 family proteins are involved in the CRISPR adaptive immune system, which defends against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of the Cas4 family are implicated in the processing of CRISPR clusters into CRISPR RNA (crRNA)... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36531"
] | [
"Cas4_exonuclease"
] | [
4506
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.12.1",
"R-HSA-174437",
"R-HSA-5685938",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69166",
"R-HSA-69473",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709570",
"R-HSA-9709603"
] | [
"EC:3.1.12.1",
"REACTOME:R-HSA-174437",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69166",
"REACTOME:R-HSA-69473"... | 17 | [
"4ic1",
"4r5q",
"8d3l",
"8d3m",
"8d3p",
"8d3q"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Ligamenvirales",
"metagenomes"
] | [
699,
2527,
1209,
2,
69
] | 5 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Mus musculus",
"Zea mays"
] | [
1,
2,
1,
5
] | 4 | true | Family | CRISPR-associated exonuclease Cas4 | CRISPR-associated exonuclease Cas4 | Cas4_exonuclease | 9 |
IPR051828 | 51,828 | HAD-like hydrolase domain-containing protein | HAD-like_hydrolase_domain | Family | 4,530 | true | false | This family of proteins includes members that are part of the HAD-like hydrolase superfamily. These proteins are characterized by a haloacid dehalogenase-like hydrolase domain, which suggests a role in catalyzing the hydrolysis of various substrates. The specific biochemical functions within this family may vary, but t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46191"
] | [
"HAD-like_hydrolase_domain"
] | [
4530
] | 1 | [] | [] | [] | 0 | [
"2zg6",
"3k1z"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caulobacter phage CcrPW",
"Eukaryota",
"metagenomes"
] | [
117,
1416,
1,
2933,
63
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
4,
2,
1,
1,
2,
1,
1
] | 9 | true | Family | HAD-like hydrolase domain-containing protein | HAD-like hydrolase domain-containing protein | HAD-like_hydrolase_domain | 7 |
IPR051830 | 51,830 | Neurogenic locus notch homolog | NOTCH_homolog | Family | 5,517 | true | false | The NOTCH family proteins are involved in cell-fate decisions and developmental processes. They function as receptors for membrane-bound ligands, such as Jagged and Delta proteins, to regulate differentiation, proliferation, and apoptosis. NOTCH proteins are essential in various biological contexts including hematopoie... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24033"
] | [
"NOTCH_homolog"
] | [
5517
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-RNO-2979096",
"R-RNO-9013507"
] | [
"REACTOME:R-RNO-2979096",
"REACTOME:R-RNO-9013507"
] | 2 | [
"5mvx"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Altarchaeum hamiconexum",
"Eukaryota",
"viral metagenome"
] | [
9,
1,
5506,
1
] | 4 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
15,
7,
2
] | 5 | true | Family | Neurogenic locus notch homolog | Neurogenic locus notch homolog | NOTCH_homolog | 3 |
IPR051831 | 51,831 | Bromodomain-containing | Bromodomain_contain_prot | Family | 8,359 | true | false | The Bromodomain-containing protein family is involved in chromatin remodeling and regulation of transcription. Members act as coactivators and corepressors, influencing the expression of target genes. They bind to promoters, modulating histone acetylation, particularly at 'Lys-9' (H3K9ac), and recruit various proteins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22881"
] | [
"Bromodomain_contain_prot"
] | [
8359
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6804758",
"R-HSA-9933939",
"R-HSA-9933947",
"R-MMU-6804758",
"R-MMU-9933939",
"R-MMU-9933947",
"R-XTR-9933947"
] | [
"REACTOME:R-HSA-6804758",
"REACTOME:R-HSA-9933939",
"REACTOME:R-HSA-9933947",
"REACTOME:R-MMU-6804758",
"REACTOME:R-MMU-9933939",
"REACTOME:R-MMU-9933947",
"REACTOME:R-XTR-9933947"
] | 7 | [
"2d9e",
"2i7k",
"2n9g",
"2rs9",
"3hme",
"3rcw",
"4lc2",
"4nqn",
"4nxj",
"4pkl",
"4qyd",
"4qyl",
"4uit",
"4uiu",
"4uiv",
"4uiw",
"4uye",
"4xy8",
"4yy4",
"4yy6",
"4yyd",
"4yyg",
"4yyh",
"4yyi",
"4yyj",
"4yyk",
"4z6h",
"4z6i",
"5ame",
"5amf",
"5c4q",
"5c7n"... | 432 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Eukaryota"
] | [
2,
8357
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
22,
2,
17,
1,
16,
9,
12,
5,
83
] | 9 | true | Family | Bromodomain-containing | Bromodomain-containing | Bromodomain_contain_prot | 7 |
IPR051832 | 51,832 | Regulators of mTOR signaling and Rac activation | mTOR-Rac_regulators | Family | 7,606 | true | false | This family of proteins includes guanine nucleotide exchange factors (GEFs) that activate Rac proteins by exchanging GDP for GTP, and are synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and beta gamma subunits of heterotrimeric G proteins. Some members function as negative regulators of the mTORC1... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22829"
] | [
"mTOR-Rac_regulators"
] | [
7606
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-8948751",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013406",
"R-HSA-9013408",
"R-HSA-9013409",
"R-HSA-9013423",
"R-MMU-193648",
"R-MMU-416482",
"R-MMU-8948751",
"R-MMU-8980692",... | [
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-8948751",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013408",
"REACTOME:... | 26 | [
"3qik",
"4yon",
"5d27",
"5d3v",
"5d3w",
"5d3x",
"5d3y",
"5fi0",
"5fi1",
"6bnm",
"6pcv",
"6vsk",
"7dkl",
"7owg",
"7pe7",
"7pe8",
"7pe9",
"7pea",
"7peb",
"7pec",
"7ped",
"7rx9",
"7syf",
"8tua",
"8u54",
"8u56",
"8u58",
"8u5c",
"8u5n",
"8u5q",
"8u5v",
"8u5x"... | 44 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
31,
7575
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
3,
11,
16,
28
] | 5 | true | Family | Regulators of mTOR signaling and Rac activation | Regulators of mTOR signaling and Rac activation | mTOR-Rac_regulators | 4 |
IPR051833 | 51,833 | Transcription-coupled DNA damage response regulator-like | TC-DDR_regulator | Family | 7,580 | true | true | This family of proteins is involved in the regulation of transcription-coupled DNA damage response. Members of this family function by recruiting the ubiquitination machinery to RNA polymerase II, facilitating its polyubiquitination, removal, and subsequent degradation in cases where transcription-coupled nucleotide ex... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16308"
] | [
"TC-DDR_regulator"
] | [
7580
] | 1 | [] | [] | [] | 0 | [
"1wj7"
] | 1 | [
"PUB00154553"
] | [
"34807903"
] | [
"PQN-59 antagonizes microRNA-mediated repression during post-embryonic temporal patterning and modulates translation and stress granule formation in C. elegans."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7580
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
35,
7,
30,
21,
1,
12,
1
] | 8 | true | Family | Transcription-coupled DNA damage response regulator-like | Transcription-coupled DNA damage response regulator-like | TC-DDR_regulator | 2 |
IPR051834 | 51,834 | RING finger E3 ubiquitin-protein ligase | RING_finger_E3_ligase | Family | 16,674 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that are involved in the ubiquitination and subsequent proteasomal degradation of various target proteins. They play roles in regulating transcription factors, particularly those with LIM domains, by mediating the degradation of their cofactors. This action ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45931"
] | [
"RING_finger_E3_ligase"
] | [
16674
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-DME-983168",
"R-HSA-983168",
"R-MMU-983168",
"R-RNO-983168",
"R-XTR-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-983168",
"REACTOME:R-XTR-983168"
] | 7 | [
"2ect",
"2l0b",
"5zbu",
"5zc4",
"6w7z",
"6w9a",
"6w9d"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"candidate division MSBL1 archaeon SCGC-AAA385M02",
"metagenomes"
] | [
3,
16600,
21,
1,
49
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
38,
2,
16,
6,
16,
19,
1,
52,
28,
3,
55
] | 11 | true | Family | RING finger E3 ubiquitin-protein ligase | RING finger E3 ubiquitin-protein ligase | RING_finger_E3_ligase | 9 |
IPR051835 | 51,835 | RAC1-specific guanine nucleotide exchange factor | RAC1-GEF | Family | 6,880 | true | false | This family of proteins includes guanine nucleotide exchange factors (GEFs) that specifically activate the GTPase RAC1, influencing various cellular processes. Members are involved in semaphorin signaling, which is critical for axonal guidance and neuronal development. They play significant roles in the assembly and di... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45858"
] | [
"RAC1-GEF"
] | [
6880
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-399955",
"R-HSA-8980692",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9035034",
"R-MMU-399955",
"R-MMU-8980692",
"R-MMU-9013148",
"R-MMU-9013149",
"R-MMU-9035034",
"R-RNO-8980692",
"R-RNO-9013148",
"R-RNO-9013149",
"R-RNO-9035034"
] | [
"REACTOME:R-HSA-399955",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9035034",
"REACTOME:R-MMU-399955",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013148",
"REACTOME:R-MMU-9013149",
"REACTOME:R-MMU-9035034",
"REACTOME:R-RNO-8980692",
"REACTOME:... | 14 | [
"4gyv",
"4gzu",
"4h6y",
"6d21",
"6d2k",
"6d2q"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
6878
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
40,
4,
17,
12,
7
] | 7 | true | Family | RAC1-specific guanine nucleotide exchange factor | RAC1-specific guanine nucleotide exchange factor | RAC1-GEF | 2 |
IPR051837 | 51,837 | Sorting Nexin/PX Domain-Containing Protein Kinase-Like | SortingNexin/PXDomain-PKLike | Family | 7,576 | true | false | The Sorting Nexin/PX Domain-Containing Protein Kinase-Like family is involved in various stages of intracellular trafficking, including protein transport from early to late endosomes and to the lysosome, potentially influencing the degradation of EGFR after EGF signaling. Members of the family may also play a role in t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22999"
] | [
"SortingNexin/PXDomain-PKLike"
] | [
7576
] | 1 | [] | [] | [] | 0 | [
"1xte",
"1xtn",
"5gw0",
"5gw1",
"6edx"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7576
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
13,
16,
13,
21,
5,
1,
10,
10,
20
] | 9 | true | Family | Sorting Nexin/PX Domain-Containing Protein Kinase-Like | Sorting Nexin/PX Domain-Containing Protein Kinase-Like | SortingNexin/PXDomain-PKLike | 5 |
IPR051838 | 51,838 | Intracellular mono-ADP-ribosyltransferase ARTD/PARP | ARTD_PARP | Family | 6,730 | true | false | The ARTD/PARP family comprises intracellular mono-ADP-ribosyltransferases involved in various cellular processes such as protein translation, stress responses, and unfolded protein response (UPR). Members of the family modify target proteins through mono-ADP-ribosylation, a post-translational modification that can regu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21328"
] | [
"ARTD_PARP"
] | [
6730
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.-",
"PWY-5381",
"PWY-5800",
"PWY-6148",
"PWY-6720",
"PWY-7018",
"PWY-7025",
"PWY-7450",
"PWY-7817",
"PWY-7981",
"R-HSA-196807",
"R-HSA-9683610",
"R-HSA-9694631"
] | [
"EC:2.4.2.-",
"METACYC:PWY-5381",
"METACYC:PWY-5800",
"METACYC:PWY-6148",
"METACYC:PWY-6720",
"METACYC:PWY-7018",
"METACYC:PWY-7025",
"METACYC:PWY-7450",
"METACYC:PWY-7817",
"METACYC:PWY-7981",
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9683610",
"REACTOME:R-HSA-9694631"
] | 13 | [
"4f0d",
"6hxr",
"6hxs",
"6w65"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae",
"viral metagenome"
] | [
6713,
10,
7
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
1,
23,
17,
12
] | 5 | true | Family | Intracellular mono-ADP-ribosyltransferase ARTD/PARP | Intracellular mono-ADP-ribosyltransferase ARTD/PARP | ARTD_PARP | 4 |
IPR051839 | 51,839 | Retinal determination transcriptional regulator | RD_transcriptional_regulator | Family | 9,367 | true | false | This family of proteins includes probable transcription factors involved in the retinal determination network. They play a role in the regulation of gene expression necessary for the induction and differentiation of specific sensory organ cells, such as the R8 photoreceptor cells in the eye. Members of this family are ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33215"
] | [
"RD_transcriptional_regulator"
] | [
9367
] | 1 | [] | [] | [] | 0 | [
"2elh"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
14,
8591,
10,
645,
107
] | 5 | [
"Drosophila melanogaster",
"Escherichia coli (strain K12)"
] | [
6,
10
] | 2 | true | Family | Retinal determination transcriptional regulator | Retinal determination transcriptional regulator | RD_transcriptional_regulator | 7 |
IPR051840 | 51,840 | NifX/NifY domain-containing protein | NifX/NifY_domain | Family | 3,298 | true | false | This family of proteins is involved in the processing of the iron-molybdenum cofactor, which is a critical component of the nitrogenase enzyme required for nitrogen fixation in certain bacteria. Members of this family are thought to play a role in the maturation or repair of the cofactor, ensuring the proper function o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33937"
] | [
"NifX/NifY_domain"
] | [
3298
] | 1 | [] | [] | [] | 0 | [
"1eo1",
"1p90",
"2kla",
"2qtd",
"2yx6"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
451,
2781,
66
] | 3 | [] | [] | 0 | true | Family | NifX/NifY domain-containing protein | NifX/NifY domain-containing protein | NifX/NifY_domain | 2 |
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