interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051958 | 51,958 | Alba-like nucleic acid-binding | Alba-like_NAB | Family | 5,646 | true | false | This family of proteins includes members that are involved in nucleic acid binding and processing. Some members have been characterized to bind DNA and RNA with relaxed sequence specificity, and are associated with subtelomeric repeats. Others are known to be components of ribonucleoprotein complexes such as ribonuclea... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13516"
] | [
"Alba-like_NAB"
] | [
5646
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6784531",
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226"
] | [
"REACTOME:R-HSA-6784531",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226"
] | 4 | [
"6ahr",
"6ahu",
"6cwx",
"6lt7"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"candidate division MSBL1"
] | [
5643,
3
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
1,
5,
2,
2,
2,
20,
4,
62
] | 9 | true | Family | Alba-like nucleic acid-binding | Alba-like nucleic acid-binding | Alba-like_NAB | 5 |
IPR051959 | 51,959 | PAK1 Kinase Regulator | PAK1-Kinase_Regulator | Family | 5,089 | true | false | This family of proteins is involved in the negative regulation of PAK1 kinase, a key player in various signaling pathways, including those that involve MAPK8 and RELA. PAK1, which is part of the PAK kinase family, is typically found as an inactive homodimer that becomes activated upon binding with small GTPases such as... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44675"
] | [
"PAK1-Kinase_Regulator"
] | [
5089
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
5077,
12
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
3,
34,
2,
2,
1,
4,
3,
1,
1,
5
] | 11 | true | Family | PAK1 Kinase Regulator | PAK1 Kinase Regulator | PAK1-Kinase_Regulator | 7 |
IPR051961 | 51,961 | Fungal Secondary Metabolite Dioxygenase | Fungal_Metabolite_Diox | Family | 3,804 | true | false | This family of proteins includes dioxygenases involved in the biosynthesis of various fungal secondary metabolites, such as ergot alkaloids, swainsonine, communesins, fumitremorgins, and kanamycin. These enzymes catalyze oxidative reactions that are essential for the formation of bioactive compounds with potential phar... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37563"
] | [
"Fungal_Metabolite_Diox"
] | [
3804
] | 1 | [] | [] | [] | 0 | [
"5zm2",
"5zm3",
"5zm4",
"6s0r",
"6s0s",
"6s0t",
"6s0u",
"6s0v",
"6s0w",
"7cl2",
"7cl3",
"7cl4",
"7cl5",
"7cl6"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
814,
2949,
2,
39
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Fungal Secondary Metabolite Dioxygenase | Fungal Secondary Metabolite Dioxygenase | Fungal_Metabolite_Diox | 8 |
IPR051962 | 51,962 | Cuticlin domain-containing protein | Cuticlin | Family | 4,796 | true | false | This family of proteins is involved in the formation and structural integrity of cuticles, which serve as protective envelopes for organisms. Members of this family play crucial roles in the development of alae, which are specialized structures formed during certain larval stages in nematodes. These proteins are implic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22907"
] | [
"Cuticlin"
] | [
4796
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
4796
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
35,
4
] | 2 | true | Family | Cuticlin domain-containing protein | Cuticlin domain-containing protein | Cuticlin | 3 |
IPR051963 | 51,963 | Adhesion G protein-coupled receptor A | Adhesion_GPCR_A | Family | 4,844 | true | false | The Adhesion G protein-coupled receptor A family is involved in various signaling pathways and cellular processes. Members of the family function as receptors that play key roles in the planar cell polarity pathway, central nervous system vascularization, and the establishment of the blood-brain barrier. They act as co... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45930"
] | [
"Adhesion_GPCR_A"
] | [
4844
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4844
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
3,
12,
13,
12
] | 5 | true | Family | Adhesion G protein-coupled receptor A | Adhesion G protein-coupled receptor A | Adhesion_GPCR_A | 8 |
IPR051964 | 51,964 | Multifunctional chaperone and stress response protein | Chaperone_stress_response | Family | 4,743 | true | false | This family of proteins includes co-chaperones that may interact with HSP70 and are implicated in ribosomal RNA biogenesis, particularly in the maturation of the 60S ribosomal subunit. Some members are involved in chromatin-related processes, such as position-effect variegation and chromosome condensation. Others funct... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44029"
] | [
"Chaperone_stress_response"
] | [
4743
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
14,
4728,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
6,
5,
2,
2,
7,
1,
2
] | 9 | true | Family | Multifunctional chaperone and stress response protein | Multifunctional chaperone and stress response protein | Chaperone_stress_response | 5 |
IPR051965 | 51,965 | Chromatin Regulation and Neuronal Gene Expression | ChromReg_NeuronalGeneExpr | Family | 4,797 | true | false | The protein family is involved in various aspects of chromatin regulation and neuronal gene expression. Members of the family are required for the correct progression through the G2 phase of the cell cycle and entry into mitosis, as well as for the repression of neuronal specific gene promoters mediated by RCOR1/CoREST... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46040"
] | [
"ChromReg_NeuronalGeneExpr"
] | [
4797
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3214815",
"R-BTA-983231",
"R-HSA-3214815",
"R-HSA-9679191",
"R-HSA-983231",
"R-MMU-3214815",
"R-MMU-983231",
"R-SCE-140342",
"R-SCE-163282",
"R-SCE-5620971",
"R-SCE-5686938",
"R-SCE-6798695",
"R-SCE-9837999"
] | [
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA-983231",
"REACTOME:R-HSA-3214815",
"REACTOME:R-HSA-9679191",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-3214815",
"REACTOME:R-MMU-983231",
"REACTOME:R-SCE-140342",
"REACTOME:R-SCE-163282",
"REACTOME:R-SCE-5620971",
"REACTOME:R-SCE-5686938",
"REACTOME:R-S... | 13 | [
"2crj",
"5jgh",
"5jh0"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Spiroplasma ixodetis",
"viral metagenome"
] | [
4794,
1,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
12,
1,
14,
9,
1,
7,
1
] | 8 | true | Family | Chromatin Regulation and Neuronal Gene Expression | Chromatin Regulation and Neuronal Gene Expression | ChromReg_NeuronalGeneExpr | 7 |
IPR051966 | 51,966 | RNA polymerase II-associated protein 3 | RPAP3 | Family | 4,076 | true | false | The RPAP3 family proteins are implicated in forming an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins. They appear to play a crucial role in connecting RNA polymerase II to regulators of protein complex formation, which is essential for transcriptional regulation. Additionally, a memb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46423"
] | [
"RPAP3"
] | [
4076
] | 1 | [] | [] | [] | 0 | [
"1a17",
"2bug",
"2l6j",
"2lsu",
"2lsv",
"4cgq",
"4cgu",
"4cgv",
"4cgw",
"6ez4",
"6fd7",
"6fdp",
"6fdt",
"6fm8",
"6fo1",
"6gxz",
"6zbk"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
26,
4048,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
5,
2,
1,
1,
7,
1,
1
] | 8 | true | Family | RNA polymerase II-associated protein 3 | RNA polymerase II-associated protein 3 | RPAP3 | 5 |
IPR051967 | 51,967 | Krueppel C2H2-type Zinc-Finger Domain-Containing Protein | Krueppel_C2H2-ZF | Family | 4,803 | true | false | This family of proteins includes transcriptional regulators that bind to specific DNA motifs to activate or repress gene transcription. They play roles in various biological processes such as brown adipose tissue differentiation, thermogenesis, chondrocyte differentiation, neuron differentiation, cellular response to r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45925"
] | [
"Krueppel_C2H2-ZF"
] | [
4803
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9018519",
"R-HSA-9764725"
] | [
"REACTOME:R-HSA-9018519",
"REACTOME:R-HSA-9764725"
] | 2 | [
"3uk3",
"4f2j",
"4is1"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4803
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
37,
1,
24,
20,
17
] | 5 | true | Family | Krueppel C2H2-type Zinc-Finger Domain-Containing Protein | Krueppel C2H2-type Zinc-Finger Domain-Containing Protein | Krueppel_C2H2-ZF | 4 |
IPR051968 | 51,968 | Zinc finger homeobox transcription regulators | ZnFinger_Homeobox_TR | Family | 4,556 | true | false | The Zinc finger homeobox protein family is characterized by its role in transcriptional regulation, with diverse functions across its members. The family includes proteins that may influence neural and muscle differentiation, pain perception, and the processing of noxious stimuli. Some members act as transcriptional re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45891"
] | [
"ZnFinger_Homeobox_TR"
] | [
4556
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-8941855",
"R-HSA-8941855",
"R-MMU-8941855"
] | [
"REACTOME:R-DME-8941855",
"REACTOME:R-HSA-8941855",
"REACTOME:R-MMU-8941855"
] | 3 | [
"2da1",
"2da2",
"2da3",
"2yrk"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4555,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
11,
4,
25,
12,
9
] | 6 | true | Family | Zinc finger homeobox transcription regulators | Zinc finger homeobox transcription regulators | ZnFinger_Homeobox_TR | 6 |
IPR051970 | 51,970 | Telomere Length Regulation TEL2 | TEL2_Regulation | Family | 4,560 | true | false | This family of proteins is involved in the regulation of the DNA damage response (DDR) and telomere length maintenance. Members of this family are components of the TTT complex, which is essential for stabilizing the levels of phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. They contribute ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15830"
] | [
"TEL2_Regulation"
] | [
4560
] | 1 | [] | [] | [] | 0 | [
"3o4z",
"7f4u",
"7ole"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4560
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
1,
6,
2,
1,
8,
3,
1,
1,
13
] | 12 | true | Family | Telomere Length Regulation TEL2 | Telomere Length Regulation TEL2 | TEL2_Regulation | 1 |
IPR051971 | 51,971 | E3 ubiquitin-protein ligase PDZ domain-containing protein | E3_ubiquitin-PDZ_ligase | Family | 4,455 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that play a role in protein ubiquitination, a post-translational modification essential for various cellular processes. Members of this family are involved in regulating the surface level of specific membrane proteins, such as MUSK, by mediating their ubiqui... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15545"
] | [
"E3_ubiquitin-PDZ_ligase"
] | [
4455
] | 1 | [] | [] | [] | 0 | [
"1wh1"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
4454,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
15,
5,
20,
10,
12
] | 6 | true | Family | E3 ubiquitin-protein ligase PDZ domain-containing protein | E3 ubiquitin-protein ligase PDZ domain-containing protein | E3_ubiquitin-PDZ_ligase | 4 |
IPR051972 | 51,972 | Glutamate-rich WD repeat-containing | Glutamate-rich_WD_repeat | Family | 4,649 | true | false | The Glutamate-rich WD repeat-containing protein family is involved in various cellular processes related to chromatin dynamics and ribosome assembly. Members of the family function as histone-binding proteins that regulate chromatin structure and facilitate the loading of minichromosome maintenance (MCM) complexes at r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45903"
] | [
"Glutamate-rich_WD_repeat"
] | [
4649
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4649
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
1,
6,
5,
1,
7,
5,
1,
1,
18
] | 12 | true | Family | Glutamate-rich WD repeat-containing | Glutamate-rich WD repeat-containing | Glutamate-rich_WD_repeat | 2 |
IPR051973 | 51,973 | tRNA Anticodon Loop Methyltransferase Regulator | tRNA_Anticodon_Mtase-Reg | Family | 4,427 | true | false | This family of proteins is involved in the post-transcriptional modification of tRNA molecules. Members of this family function in partnership with specific methyltransferases to methylate the 2'-O-ribose of nucleotides at the 34th position of the tRNA anticodon loop. This methylation is crucial for the correct positio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14344"
] | [
"tRNA_Anticodon_Mtase-Reg"
] | [
4427
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-9013420",
"R-DME-9013424",
"R-HSA-9013420",
"R-HSA-9013424",
"R-HSA-9696264",
"R-HSA-9696270",
"R-HSA-9696273",
"R-MMU-9013420",
"R-MMU-9013424",
"R-MMU-9696264",
"R-MMU-9696270",
"R-MMU-9696273",
"R-RNO-9013420",
"R-RNO-9013424",
"R-RNO-9696264",
"R-RNO-9696270",
"R-RNO-96962... | [
"REACTOME:R-DME-9013420",
"REACTOME:R-DME-9013424",
"REACTOME:R-HSA-9013420",
"REACTOME:R-HSA-9013424",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-9013420",
"REACTOME:R-MMU-9013424",
"REACTOME:R-MMU-9696264",
"REACTOME:R-MMU-9696270",
"REACTOM... | 25 | [
"6jp6",
"6jpl"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4427
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
4,
1,
16,
5,
1,
4,
3,
1,
1,
17
] | 11 | true | Family | tRNA Anticodon Loop Methyltransferase Regulator | tRNA Anticodon Loop Methyltransferase Regulator | tRNA_Anticodon_Mtase-Reg | 9 |
IPR051974 | 51,974 | Poly(U)-binding-splicing regulator | PUF60_regulator | Family | 4,248 | true | false | This family of proteins is involved in nuclear processes such as pre-mRNA splicing, transcription regulation, and apoptosis. They act as DNA- and RNA-binding proteins, regulating MYC transcription in association with FUBP1 through the core-TFIIH basal transcription factor. They can function as transcriptional repressor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47330"
] | [
"PUF60_regulator"
] | [
4248
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72163",
"R-DME-72163",
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-CEL-72163",
"REACTOME:R-DME-72163",
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 6 | [
"2dny",
"2kxf",
"2kxh",
"2qfj",
"3dxb",
"3ue2",
"3us5",
"3uwt",
"5kvy",
"5kw1",
"5kw6",
"5kwq",
"6lur",
"6slo",
"7q8a",
"7z3x"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4248
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
2,
9,
2,
8
] | 6 | true | Family | Poly(U)-binding-splicing regulator | Poly(U)-binding-splicing regulator | PUF60_regulator | 7 |
IPR051975 | 51,975 | Mitochondrial Large Ribosomal Subunit mL45 | mtLSU_mL45 | Family | 4,046 | true | false | This family of proteins is involved in the assembly and function of the mitochondrial ribosome, which is responsible for protein synthesis within mitochondria. These proteins are part of the large ribosomal subunit and are specific to mitochondria, indicating a specialized role in the translation of mitochondrial-encod... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28554"
] | [
"mtLSU_mL45"
] | [
4046
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5389840",
"R-CEL-5419276",
"R-CEL-9937383",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-CEL-5389840",
"REACTOME:R-CEL-5419276",
"REACTOME:R-CEL-9937383",
"REACTOME:R-DME-5389840",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOM... | 13 | [
"3j7y",
"3j9m",
"4ce4",
"4v1a",
"5aj4",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5h",
"7a5i",
"7a5j",
"7a5k",
"7l08"... | 91 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"Eukaryota",
"ecological metagenomes"
] | [
103,
3941,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
3,
1,
5,
3,
1,
2,
3,
5
] | 10 | true | Family | Mitochondrial Large Ribosomal Subunit mL45 | Mitochondrial Large Ribosomal Subunit mL45 | mtLSU_mL45 | 9 |
IPR051976 | 51,976 | Synaptopodin domain-containing protein | Synaptopodin_domain | Family | 4,183 | true | false | This family of proteins is involved in the regulation of cell migration and actin cytoskeleton dynamics. Members of this family have actin-binding and actin-bundling activities, which contribute to the formation of various actin structures such as stress fibers, lamellipodia, and actin networks. These proteins are impl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24217"
] | [
"Synaptopodin_domain"
] | [
4183
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4183
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
8,
13,
17,
12
] | 5 | true | Family | Synaptopodin domain-containing protein | Synaptopodin domain-containing protein | Synaptopodin_domain | 2 |
IPR051977 | 51,977 | Rab11-interacting regulator of endocytosis and ciliogenesis | Rab11-interacting_regulator | Family | 4,120 | true | false | This family of proteins acts as downstream effectors for Rab11 GTPase, playing a crucial role in endocytic trafficking and ciliogenesis. They are involved in membrane delivery and the movement of sorting endosomes along microtubules to generate the endocytic recycling compartment. These proteins facilitate dynein motor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15726"
] | [
"Rab11-interacting_regulator"
] | [
4120
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5620916",
"R-HSA-5620916",
"R-MMU-5620916"
] | [
"REACTOME:R-DRE-5620916",
"REACTOME:R-HSA-5620916",
"REACTOME:R-MMU-5620916"
] | 3 | [
"2d7c",
"2hv8",
"4d0m",
"4uj3",
"4uj4"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4120
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
9,
14,
12,
2,
9
] | 6 | true | Family | Rab11-interacting regulator of endocytosis and ciliogenesis | Rab11-interacting regulator of endocytosis and ciliogenesis | Rab11-interacting_regulator | 2 |
IPR051978 | 51,978 | Rho GTPase-activating domain-containing protein | Rho-GAP_domain | Family | 4,094 | true | false | This family of proteins includes Rho GTPase-activating proteins (GAPs) that regulate the Rho family of GTPases. Members of this family are involved in various cellular processes such as cell differentiation, adhesion, migration, and morphogenesis of tissues like the retina and cerebral hemispheres. They play roles in a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46005"
] | [
"Rho-GAP_domain"
] | [
4094
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-416550",
"R-CFA-8849471",
"R-CFA-8980692",
"R-CFA-9013026",
"R-CFA-9013106",
"R-CFA-9013148",
"R-CFA-9013149",
"R-CFA-9013404",
"R-CFA-9013405",
"R-CFA-9013406",
"R-CFA-9013408",
"R-CFA-9013409",
"R-CFA-9013423",
"R-CFA-9696264",
"R-CFA-9696270",
"R-CFA-9696273",
"R-DME-350407... | [
"REACTOME:R-CFA-416550",
"REACTOME:R-CFA-8849471",
"REACTOME:R-CFA-8980692",
"REACTOME:R-CFA-9013026",
"REACTOME:R-CFA-9013106",
"REACTOME:R-CFA-9013148",
"REACTOME:R-CFA-9013149",
"REACTOME:R-CFA-9013404",
"REACTOME:R-CFA-9013405",
"REACTOME:R-CFA-9013406",
"REACTOME:R-CFA-9013408",
"REACTOME... | 77 | [
"2ee4",
"2ee5",
"2k85",
"3c5h",
"3fk2",
"5irc",
"5u4u",
"5u4v",
"6d4g"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4094
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
7,
10,
8,
6
] | 6 | true | Family | Rho GTPase-activating domain-containing protein | Rho GTPase-activating domain-containing protein | Rho-GAP_domain | 2 |
IPR051979 | 51,979 | B-box zinc finger domain-containing protein | B-box_zinc_finger | Family | 5,282 | true | false | This family of proteins includes transcription factors that are primarily involved in the regulation of seedling photomorphogenesis. Members of this family act as either positive or negative regulators of this process, influencing various aspects such as hypocotyl elongation, chloroplast biogenesis, and responses to li... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31832"
] | [
"B-box_zinc_finger"
] | [
5282
] | 1 | [] | [] | [] | 0 | [
"7vsp",
"7vsq",
"7wsj"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Luteolibacter flavescens"
] | [
5281,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
31,
28,
59
] | 3 | true | Family | B-box zinc finger domain-containing protein | B-box zinc finger domain-containing protein | B-box_zinc_finger | 7 |
IPR051980 | 51,980 | WD repeat domain-containing protein MORG1 | WD_repeat_MORG1 | Family | 4,101 | true | false | This family of proteins functions as molecular scaffolds for various multimeric protein complexes. They play a role in the assembly of scaffolds for the ERK signaling pathway, modulating ERK activation in response to specific stimuli. These proteins can either enhance or inhibit ERK activation depending on their concen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22842"
] | [
"WD_repeat_MORG1"
] | [
4101
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-5674135",
"R-DRE-5674135",
"R-HSA-5674135",
"R-MMU-5674135",
"R-RNO-5674135"
] | [
"REACTOME:R-DDI-5674135",
"REACTOME:R-DRE-5674135",
"REACTOME:R-HSA-5674135",
"REACTOME:R-MMU-5674135",
"REACTOME:R-RNO-5674135"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
3,
4097,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
5,
1,
1,
1,
5,
2,
1,
2,
5,
1,
9
] | 11 | true | Family | WD repeat domain-containing protein MORG1 | WD repeat domain-containing protein MORG1 | WD_repeat_MORG1 | 4 |
IPR051981 | 51,981 | Alpha-1,4-N-acetylglucosaminyltransferase | A4GCT | Family | 3,793 | true | true | This entry represents Alpha-1,4-N-acetylglucosaminyltransferase and related proteins. Members of this family catalyse the transfer of sugar moieties from nucleotide sugars to acceptor molecules, forming various glycosidic linkages. Specifically, lactosylceramide 4-alpha-galactosyltransferases from this family add galac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12042"
] | [
"Glycosyltransf_32"
] | [
3793
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1.228",
"PWY-7838",
"R-DME-913709",
"R-DME-9840309",
"R-HSA-913709",
"R-HSA-9840309",
"R-MMU-913709",
"R-MMU-9840309",
"R-RNO-9840309"
] | [
"EC:2.4.1.228",
"METACYC:PWY-7838",
"REACTOME:R-DME-913709",
"REACTOME:R-DME-9840309",
"REACTOME:R-HSA-913709",
"REACTOME:R-HSA-9840309",
"REACTOME:R-MMU-913709",
"REACTOME:R-MMU-9840309",
"REACTOME:R-RNO-9840309"
] | 9 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
241,
3548,
4
] | 3 | [
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
30,
5,
4
] | 4 | true | Family | Alpha-1,4-N-acetylglucosaminyltransferase | Alpha-1,4-N-acetylglucosaminyltransferase | A4GCT | 8 |
IPR051982 | 51,982 | Ciliary Assembly and Mitochondrial Import | CiliaryAsmbly_MitoImport | Family | 3,578 | true | false | The protein family is involved in distinct cellular processes. Some members play a role in the cytoplasmic assembly and/or trafficking of ciliary or axonemal dynein arms, which are essential for ciliary and flagellar movement, and may be implicated in fertilization. These members also exhibit GTPase activity. Other mem... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45984"
] | [
"CiliaryAsmbly_MitoImport"
] | [
3578
] | 1 | [] | [] | [] | 0 | [
"6i57",
"7bev"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
3572
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
5,
3,
11
] | 5 | true | Family | Ciliary Assembly and Mitochondrial Import | Ciliary Assembly and Mitochondrial Import | CiliaryAsmbly_MitoImport | 9 |
IPR051983 | 51,983 | WD repeat and SOCS box domain-containing protein | WSB_SOCS-box_domain | Family | 3,376 | true | false | This family of proteins includes components that are likely involved in ubiquitination and proteasomal degradation pathways. They are thought to act as substrate-recognition parts of SCF-like ECS E3 ubiquitin ligase complexes. These complexes play a crucial role in targeting specific proteins for ubiquitination, markin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15622"
] | [
"WSB_SOCS-box_domain"
] | [
3376
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-8951664",
"R-DRE-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-XTR-8951664",
"R-XTR-983168"
] | [
"REACTOME:R-DRE-8951664",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-XTR-8951664",
"REACTOME:R-XTR-983168"
] | 8 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megamimivirinae",
"Methanobacteriota"
] | [
265,
3103,
6,
2
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
18,
13,
8
] | 4 | true | Family | WD repeat and SOCS box domain-containing protein | WD repeat and SOCS box domain-containing protein | WSB_SOCS-box_domain | 4 |
IPR051984 | 51,984 | Alsin | Alsin | Family | 3,717 | true | true | Alsin functions as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, particularly Rac1, in addition to its role as a Rab5 GEF. It contains a DH domain and a PH domain ( ). This dual GEF activity links endocytic processes (via Rab5) and actin cytoskeleton remodelling (via Rac1), critical for neuronal me... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46089"
] | [
"Alsin_GEFs/MotNeuronReg"
] | [
3717
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8876198",
"R-DME-8876198",
"R-DME-9013149",
"R-HSA-8876198",
"R-HSA-9013149",
"R-MMU-8876198",
"R-MMU-9013149",
"R-RNO-8876198",
"R-RNO-9013149"
] | [
"REACTOME:R-BTA-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-DME-9013149",
"REACTOME:R-HSA-8876198",
"REACTOME:R-HSA-9013149",
"REACTOME:R-MMU-8876198",
"REACTOME:R-MMU-9013149",
"REACTOME:R-RNO-8876198",
"REACTOME:R-RNO-9013149"
] | 9 | [] | 0 | [
"PUB00160482",
"PUB00160483"
] | [
"15033976",
"25309324"
] | [
"Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.",
"The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases."
] | [
2004,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Salinispora arenicola"
] | [
3716,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
1,
39,
5,
8
] | 5 | true | Family | Alsin | Alsin | Alsin | 9 |
IPR051985 | 51,985 | Non-receptor type tyrosine-specific phosphatase | NR_tyrosine_phosphatase | Family | 3,543 | true | false | This family of proteins includes non-receptor type tyrosine-specific phosphatases involved in a variety of cellular processes. They dephosphorylate receptor and non-receptor protein tyrosine kinases, regulating signaling pathways related to hematopoiesis, inflammation, cell proliferation and differentiation, glucose ho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46047"
] | [
"NR_tyrosine_phosphatase"
] | [
3543
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.3.48",
"R-DME-210688",
"R-DME-210693",
"R-DME-354192",
"R-DME-77387",
"R-DME-877312",
"R-DME-9833482",
"R-DME-9860927",
"R-HSA-354192",
"R-HSA-6807004",
"R-HSA-77387",
"R-HSA-877312",
"R-HSA-8849472",
"R-HSA-9008059",
"R-HSA-9022699",
"R-HSA-912694",
"R-HSA-982772",
"R-HSA-983... | [
"EC:3.1.3.48",
"REACTOME:R-DME-210688",
"REACTOME:R-DME-210693",
"REACTOME:R-DME-354192",
"REACTOME:R-DME-77387",
"REACTOME:R-DME-877312",
"REACTOME:R-DME-9833482",
"REACTOME:R-DME-9860927",
"REACTOME:R-HSA-354192",
"REACTOME:R-HSA-6807004",
"REACTOME:R-HSA-77387",
"REACTOME:R-HSA-877312",
"... | 37 | [
"1a5y",
"1aax",
"1bzc",
"1bzh",
"1bzj",
"1c83",
"1c84",
"1c85",
"1c86",
"1c87",
"1c88",
"1ecv",
"1een",
"1eeo",
"1g1f",
"1g1g",
"1g1h",
"1g7f",
"1g7g",
"1gfy",
"1i57",
"1jf7",
"1kak",
"1kav",
"1l8g",
"1l8k",
"1lqf",
"1nl9",
"1nny",
"1no6",
"1nwe",
"1nwl"... | 442 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3543
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
5,
13,
7,
10
] | 5 | true | Family | Non-receptor type tyrosine-specific phosphatase | Non-receptor type tyrosine-specific phosphatase | NR_tyrosine_phosphatase | 7 |
IPR051986 | 51,986 | Innate Immunity and Apoptosis Regulator | Innate_Immune_Apopt_Reg | Family | 3,721 | true | false | The protein family is involved in the regulation of innate immune responses and apoptosis. Members act as negative feedback regulators, controlling excessive immune reactions by modulating pathways such as Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH). They interact with key signaling molecules like T... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16295"
] | [
"Innate_Immune_Apopt_Reg"
] | [
3721
] | 1 | [
"REACTOME"
] | [
"R-HSA-909733"
] | [
"REACTOME:R-HSA-909733"
] | 1 | [
"2d9k"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Methanoperedens nitratireducens",
"Eukaryota",
"Hyperionvirus sp.",
"marine sediment metagenome"
] | [
1,
3718,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
4,
14,
11,
7,
11,
20
] | 7 | true | Family | Innate Immunity and Apoptosis Regulator | Innate Immunity and Apoptosis Regulator | Innate_Immune_Apopt_Reg | 4 |
IPR051987 | 51,987 | Sigma-2 receptor-like | Sigma-2_receptor-like | Family | 3,663 | true | false | This family of proteins includes intracellular receptors that are known to bind various drugs and are highly expressed in proliferating cells. They are thought to play a significant role in regulating cell survival, morphology, and differentiation. Members of this family may also act as regulators of cellular cholester... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31204"
] | [
"Sigma-2_receptor-like"
] | [
3663
] | 1 | [] | [] | [] | 0 | [
"7m93",
"7m94",
"7m95",
"7m96",
"7mfi"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
49,
3610,
4
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
9,
1,
5,
1,
1,
7,
4,
1,
1,
6
] | 10 | true | Family | Sigma-2 receptor-like | Sigma-2 receptor-like | Sigma-2_receptor-like | 4 |
IPR051988 | 51,988 | Homologous Recombination Repair RAD51 Paralog | HRR_RAD51_Paralog | Family | 3,498 | true | false | This family of proteins is involved in the homologous recombination repair (HRR) pathway, which is crucial for the repair of double-stranded DNA breaks that can occur during DNA replication or result from DNA-damaging agents. Members of this family are known to bind to single-stranded DNA (ssDNA) and exhibit DNA-depend... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46457"
] | [
"HRR_RAD51_Paralog"
] | [
3498
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5685942",
"R-BTA-5693568",
"R-BTA-5693579",
"R-BTA-5693616",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693616",
"R-HSA-6796648",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709603",
"R-MMU-5685942",
"R-MMU-5693568",
"R-MMU-56935... | [
"REACTOME:R-BTA-5685942",
"REACTOME:R-BTA-5693568",
"REACTOME:R-BTA-5693579",
"REACTOME:R-BTA-5693616",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6796648",
"REACTOME:R-HSA-9701192",
"REACTOM... | 18 | [
"2kz3",
"8faz",
"8gbj",
"8ouy",
"8ouz",
"9svy",
"9sw0"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"candidate division WOR-1 bacterium RIFCSPHIGHO2_01_FULL_53_15",
"ecological metagenomes"
] | [
4,
3491,
1,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
9,
1,
1,
3,
10,
9,
5,
8,
1,
4
] | 10 | true | Family | Homologous Recombination Repair RAD51 Paralog | Homologous Recombination Repair RAD51 Paralog | HRR_RAD51_Paralog | 8 |
IPR051989 | 51,989 | FK506-binding protein-like isomerase | FKBP-like_isomerase | Family | 3,188 | true | false | This family of proteins includes peptidyl-prolyl cis-trans isomerases (PPIases) that are known to accelerate the folding of proteins during protein synthesis. These enzymes facilitate the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, which is a rate-limiting step during folding. Members of t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46046"
] | [
"FKBP-like_isomerase"
] | [
3188
] | 1 | [
"EC",
"REACTOME"
] | [
"5.2.1.8",
"R-HSA-390471"
] | [
"EC:5.2.1.8",
"REACTOME:R-HSA-390471"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
47,
3137,
4
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
15,
24,
5,
9
] | 5 | true | Family | FK506-binding protein-like isomerase | FK506-binding protein-like isomerase | FKBP-like_isomerase | 3 |
IPR051990 | 51,990 | Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting | CCPG1/PBIP1 | Family | 3,160 | true | true | CCPG1 is a type II membrane protein localised to cytoplasmic granule membranes that limits guanine nucleotide exchange activity of MCF2L toward RHOA which results in an inhibition of both its transcriptional activation ability and its transforming activity [ ] and may be involved in regulation of Rho-mediated signallin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28638"
] | [
"CCPG1/PBIP1"
] | [
3160
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053649",
"PUB00055477",
"PUB00055479",
"PUB00074594"
] | [
"15642098",
"10825160",
"17043237",
"9383053"
] | [
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.",
"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.",
"An inherent role of microtubule network in the action of nuclear receptor.",
"Human C... | [
2005,
2000,
2006,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3160
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
15,
9,
21
] | 4 | true | Family | Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting | Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting | CCPG1/PBIP1 | 9 |
IPR051991 | 51,991 | Mitochondrial ribosomal protein bL32 | Mitoribosomal_protein_bL32 | Family | 3,333 | true | false | This family of proteins includes components of the mitochondrial ribosome, also known as mitoribosomes. These proteins are involved in the synthesis of mitochondrial genome-encoded proteins, which are essential for various cellular processes, including the mitochondrial respiratory chain. The mitoribosomes are closely ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21026"
] | [
"Mitoribosomal_protein_bL32"
] | [
3333
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9837999",
"R-BTA-9937383",
"R-CEL-5389840",
"R-CEL-5419276",
"R-CEL-9837999",
"R-CEL-9937383",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-9837999",
"R-DME-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9837999",
"R-HSA-99373... | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9937383",
"REACTOME:R-CEL-5389840",
"REACTOME:R-CEL-5419276",
"REACTOME:R-CEL-9837999",
"REACTOME:R-CEL-9937383",
"REACTOME:R-DME-5389840",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-9837999",
"REACTOM... | 23 | [
"3j6b",
"3j7y",
"3j9m",
"4ce4",
"4v19",
"5aj4",
"5mrc",
"5mre",
"5mrf",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6xyw",
"6ydp",
"6ydw",
"6ywe",
"6yws",
"6ywv",
"6ywx",
"6ywy",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc"... | 104 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3333
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
1,
1,
3,
1,
1,
4,
2,
1,
1,
6
] | 12 | true | Family | Mitochondrial ribosomal protein bL32 | Mitochondrial ribosomal protein bL32 | Mitoribosomal_protein_bL32 | 2 |
IPR051992 | 51,992 | Oxidative Stress Response Regulator | OxStress_Response_Reg | Family | 4,052 | true | false | This family of proteins is involved in promoting tolerance to various metals and oxidizing chemicals. Members of this family may function as transcription activators and are potentially involved in chromatin remodeling during stress responses. Some proteins in this family are known to interact with histone deacetylase ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33172"
] | [
"OxStress_Response_Reg"
] | [
4052
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4052
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
24,
30,
49
] | 3 | true | Family | Oxidative Stress Response Regulator | Oxidative Stress Response Regulator | OxStress_Response_Reg | 5 |
IPR051993 | 51,993 | Glycosyltransferase 8 | Glycosyltransferase_8 | Family | 3,226 | true | false | The glycosyltransferase 8 family is characterized by its enzymatic function in post-translational modification of proteins. Members of this family are involved in the elongation of O-linked glucose residues that are attached to EGF-like repeats in the extracellular domain of Notch proteins. They achieve this by catalyz... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46012"
] | [
"Glycosyltransferase_8"
] | [
3226
] | 1 | [
"EC",
"REACTOME"
] | [
"2.4.2.42",
"R-HSA-9926550"
] | [
"EC:2.4.2.42",
"REACTOME:R-HSA-9926550"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanocorpusculum"
] | [
3,
3221,
2
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
2,
4,
3,
8
] | 5 | true | Family | Glycosyltransferase 8 | Glycosyltransferase 8 | Glycosyltransferase_8 | 5 |
IPR051994 | 51,994 | WW domain-binding | WW_domain-binding | Family | 3,122 | true | false | The WW domain-binding protein family is characterized by its interaction with other proteins through PPxY motifs, which are known to mediate interactions with proteins such as WWOX and NEDD4. Members of this family are involved in various cellular processes, including acting as synapse-to-nucleus messengers that promot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16209"
] | [
"WW_domain-binding"
] | [
3122
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
3119,
3
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
10,
8,
15
] | 4 | true | Family | WW domain-binding | WW domain-binding | WW_domain-binding | 5 |
IPR051995 | 51,995 | Ciliary function-associated GTPase | Ciliary_GTPase | Family | 3,049 | true | false | This family of proteins includes small GTPases involved in ciliary function and development. Members are cilium-specific and play a crucial role in controlling the microtubule-based axoneme structure of cilia. They are implicated in maintaining the association between intraflagellar transport (IFT) subcomplexes A and B... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46090"
] | [
"Ciliary_GTPase"
] | [
3049
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9013406",
"R-CEL-9646399",
"R-DRE-9013406",
"R-DRE-9646399",
"R-HSA-5624958",
"R-HSA-9013406",
"R-HSA-9013409",
"R-HSA-9613829",
"R-HSA-9615710",
"R-HSA-9646399",
"R-MMU-5624958",
"R-MMU-9013406",
"R-MMU-9646399"
] | [
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9646399",
"REACTOME:R-DRE-9013406",
"REACTOME:R-DRE-9646399",
"REACTOME:R-HSA-5624958",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013409",
"REACTOME:R-HSA-9613829",
"REACTOME:R-HSA-9615710",
"REACTOME:R-HSA-9646399",
"REACTOME:R-MMU-5624958",
"REACTOM... | 13 | [
"4m9q",
"5di3"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3049
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
14,
17,
5,
8
] | 5 | true | Family | Ciliary function-associated GTPase | Ciliary function-associated GTPase | Ciliary_GTPase | 6 |
IPR051996 | 51,996 | Plant Cytochrome P450 78A | Cytochrome_P450_78A | Family | 3,904 | true | false | The Cytochrome P450 78A family is involved in various developmental processes in plants. Members of this family play crucial roles in regulating the growth of leaves, flowers, seeds, and fruits, often acting in a non-cell-autonomous manner. They are implicated in the timing of lateral organ formation and the duration o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47946"
] | [
"Cytochrome_P450_78A"
] | [
3904
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3904
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
35,
28
] | 3 | true | Family | Plant Cytochrome P450 78A | Plant Cytochrome P450 78A | Cytochrome_P450_78A | 6 |
IPR051997 | 51,997 | Serine/threonine-protein kinase NEK | STK_NEK | Family | 3,050 | true | false | This family of proteins includes serine/threonine kinases that play a crucial role in cell cycle regulation, particularly in mitotic progression and spindle dynamics. They are involved in the phosphorylation of various substrates, including histones and other kinases, which is essential for chromosome separation and ce... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44535"
] | [
"STK_NEK"
] | [
3050
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11",
"R-HSA-2980767",
"R-HSA-3301854",
"R-HSA-9648025",
"R-MMU-2980767"
] | [
"EC:2.7.11",
"REACTOME:R-HSA-2980767",
"REACTOME:R-HSA-3301854",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-2980767"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3050
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
1,
14,
4,
7
] | 6 | true | Family | Serine/threonine-protein kinase NEK | Serine/threonine-protein kinase NEK | STK_NEK | 7 |
IPR051998 | 51,998 | Meteorin-like | Meteorin-like | Family | 2,736 | true | false | This family of proteins is involved in neurogenesis, specifically in glial cell differentiation and axonal network formation. Members of this family promote the differentiation of astrocytes and their transformation into radial glia, as well as the extension of axons in sensory ganglia neurons by activating satellite g... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28593"
] | [
"Meteorin-like"
] | [
2736
] | 1 | [] | [] | [] | 0 | [
"7tl6",
"7tlh",
"7tlw"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2736
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
6,
10
] | 4 | true | Family | Meteorin-like | Meteorin-like | Meteorin-like | 2 |
IPR051999 | 51,999 | Mediator complex subunit 1 | Mediator_complex_subunit_1 | Family | 2,552 | true | false | This family of proteins functions as components of the Mediator complex, which is a coactivator essential for the regulated transcription of RNA polymerase II-dependent genes. These proteins act as a bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12881"
] | [
"Mediator_complex_subunit_1"
] | [
2552
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-383280",
"R-DME-400206",
"R-DME-9018519",
"R-DME-9707564",
"R-DME-9841922",
"R-HSA-1368108",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-2151201",
"R-HSA-2426168",
"R-HSA-381340",
"R-HSA-383280",
"R-HSA-400206",
"R-HSA-9018519",
"R-HSA-9707564",
"R-HSA-9707616",
"R-HSA-9833110",
... | [
"REACTOME:R-DME-383280",
"REACTOME:R-DME-400206",
"REACTOME:R-DME-9018519",
"REACTOME:R-DME-9707564",
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1368108",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-381340",
"REACTOME:R-... | 24 | [
"7emf",
"7ena",
"7enc",
"7enj",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactobacillales"
] | [
2545,
7
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
4,
2,
5
] | 5 | true | Family | Mediator complex subunit 1 | Mediator complex subunit 1 | Mediator_complex_subunit_1 | 7 |
IPR052001 | 52,001 | MHC Class II Gamma Chain/Thyroglobulin | MHC-II_Gamma/Thyroglobulin | Family | 2,376 | true | false | The protein family includes two distinct groups with different functions. One group, the HLA/H-2 class II histocompatibility antigen gamma chains, plays a pivotal role in the immune system by stabilizing MHC class II alpha/beta heterodimers, facilitating antigen presentation, and interacting with CD44 to enhance T-cell... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14093"
] | [
"MHC-II_Gamma/Thyroglobulin"
] | [
2376
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-2132295",
"R-HSA-9925563",
"R-MMU-202733",
"R-MMU-2132295",
"R-RNO-202733",
"R-RNO-2132295"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-9925563",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-2132295",
"REACTOME:R-RNO-202733",
"REACTOME:R-RNO-2132295"
] | 7 | [
"1icf",
"1iie",
"1l3h",
"6scj",
"7b75",
"7n4y",
"7qtq",
"8vrw",
"8vsp"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadati"
] | [
2374,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
17,
6,
17
] | 4 | true | Family | MHC Class II Gamma Chain/Thyroglobulin | MHC Class II Gamma Chain/Thyroglobulin | MHC-II_Gamma/Thyroglobulin | 4 |
IPR052002 | 52,002 | Even-skipped homeobox domain-containing protein | Even-skipped_HD | Family | 2,472 | true | false | This family of proteins includes transcription factors that are characterized by the presence of an even-skipped homeobox domain. They are involved in various developmental processes, including the specification of neuronal cell types and pattern formation during embryogenesis. Members of this family can act as transcr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46294"
] | [
"Even-skipped_HD"
] | [
2472
] | 1 | [] | [] | [] | 0 | [
"1jgg"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2472
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
11,
18,
4,
6,
3
] | 6 | true | Family | Even-skipped homeobox domain-containing protein | Even-skipped homeobox domain-containing protein | Even-skipped_HD | 6 |
IPR052003 | 52,003 | Homologous Recombination DNA-Binding Protein | HR_DNA-Binding_Protein | Family | 2,317 | true | false | This family of proteins is involved in DNA repair mechanisms, specifically through the promotion of homologous recombination. Members of this family exhibit structure-specific DNA-binding properties and are known to enhance the formation of DNA joint molecules, such as D-loops, which are critical intermediates in DNA r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15361"
] | [
"HR_DNA-Binding_Protein"
] | [
2317
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-5685942",
"R-GGA-5693568",
"R-GGA-5693579",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709603",
"R-MMU-5685942",
"R-MMU-5693568",
"R-MMU-5693579"
] | [
"REACTOME:R-GGA-5685942",
"REACTOME:R-GGA-5693568",
"REACTOME:R-GGA-5693579",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-9701192",
"REACTOME:R-HSA-9704331",
"REACTOME:R-HSA-9704646",
"REACTOME:R-HSA-9709603",
"REACTOM... | 14 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
3,
2310,
3,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
13,
7,
12
] | 4 | true | Family | Homologous Recombination DNA-Binding Protein | Homologous Recombination DNA-Binding Protein | HR_DNA-Binding_Protein | 5 |
IPR052004 | 52,004 | Axonemal Dynein Assembly Factor 4 | Dynein_assembly_factor_4 | Family | 2,015 | true | false | This family of proteins is involved in the development of the cerebral neocortex, specifically in neuronal migration. Members of this family are also implicated in the regulation of estrogen receptor stability and proteasomal degradation, which is crucial for neuronal differentiation, survival, and plasticity. Addition... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46492"
] | [
"Dynein_assembly_factor_4"
] | [
2015
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome",
"unclassified Candidatus Thermoprofundales"
] | [
2,
2008,
2,
3
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
7,
7,
3
] | 5 | true | Family | Axonemal Dynein Assembly Factor 4 | Axonemal Dynein Assembly Factor 4 | Dynein_assembly_factor_4 | 8 |
IPR052007 | 52,007 | Bud site selection protein 4 | Bud4 | Family | 1,826 | true | false | This family of proteins is involved in the regulation of cell polarity and morphogenesis, particularly in the process of bud site selection and septin organization at the bud neck during mitosis. Members of this family cooperate with other proteins to recognize spatial landmarks, which then serve as references for the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36100"
] | [
"Bud4"
] | [
1826
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1826
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Family | Bud site selection protein 4 | Bud site selection protein 4 | Bud4 | 5 |
IPR052009 | 52,009 | Archaemetzincin | Archaemetzincin | Family | 1,412 | true | false | This family of proteins includes enzymes with a probable role as zinc metalloproteases. Members of this family are characterized by their ability to bind zinc, which is essential for their catalytic activity. These enzymes are likely involved in the breakdown of various peptide substrates, utilizing the metal ion to hy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32205"
] | [
"Archaemetzincin"
] | [
1412
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"anaerobic digester metagenome"
] | [
8,
1403,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
11,
9,
6
] | 4 | true | Family | Archaemetzincin | Archaemetzincin | Archaemetzincin | 1 |
IPR052011 | 52,011 | Centromere-associated NAC/CAD complex protein | CENP-NAC/CAD_complex | Family | 1,352 | true | false | This family of proteins is involved in the structural and functional organization of centromeres. Members of this family are key components of the CENPA-NAC complex, which is crucial for kinetochore protein assembly, mitotic progression, and chromosome segregation. They are responsible for the recruitment of the CENPA-... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46790"
] | [
"CENP-NAC/CAD_complex"
] | [
1352
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-141444",
"R-GGA-2467813",
"R-GGA-2500257",
"R-GGA-5663220",
"R-GGA-606279",
"R-GGA-9648025",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-606279",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
... | [
"REACTOME:R-GGA-141444",
"REACTOME:R-GGA-2467813",
"REACTOME:R-GGA-2500257",
"REACTOME:R-GGA-5663220",
"REACTOME:R-GGA-606279",
"REACTOME:R-GGA-9648025",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-606279",
"REACTOME:R-... | 34 | [
"6buz",
"6c0w",
"6eqt",
"6muo",
"6mup",
"7pkn",
"7qoo",
"7r5s",
"7r5v",
"7u46",
"7u47",
"7u4d",
"7xhn",
"7xho",
"7ywx",
"7yyh"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1352
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2,
6
] | 4 | true | Family | Centromere-associated NAC/CAD complex protein | Centromere-associated NAC/CAD complex protein | CENP-NAC/CAD_complex | 6 |
IPR052012 | 52,012 | Glycosyltransferase_92 | GTase_92 | Family | 1,027 | true | false | This family of proteins includes enzymes that are classified as glycosyltransferases, specifically within the glycosyltransferase 92 group. These enzymes are responsible for the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. This process is crucial fo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21645"
] | [
"GTase_92"
] | [
1027
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
1027
] | 1 | [
"Caenorhabditis elegans"
] | [
31
] | 1 | true | Family | Glycosyltransferase_92 | Glycosyltransferase_92 | GTase_92 | 9 |
IPR052013 | 52,013 | Mouse Killer cell lectin-like receptors | Mouse_KLRs | Family | 587 | true | false | The Killer cell lectin-like receptor family in mice includes receptors expressed on natural killer (NK) cells. These receptors recognize class I MHC molecules, playing a crucial role in the regulation of NK cell activity and the immune response. They are involved in the surveillance against infected or transformed cell... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46329"
] | [
"Mouse_KLRs"
] | [
587
] | 1 | [] | [] | [] | 0 | [
"1ja3",
"1p1z",
"1p4l",
"1qo3",
"3c8j",
"3c8k",
"3cad",
"3g8k",
"3g8l",
"4jo8",
"5j6g"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
587
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
107,
64
] | 3 | true | Family | Mouse Killer cell lectin-like receptors | Mouse Killer cell lectin-like receptors | Mouse_KLRs | 8 |
IPR052014 | 52,014 | Dictyostelium Tiger | Dictyostelium_Tiger | Family | 542 | true | false | The Tiger protein family in Dictyostelium discoideum is involved in cell-cell recognition and signaling, essential for social amoebae aggregation and multicellular development. Members of the family, such as Contact site A protein, mediate cell binding through homophilic interactions, possibly elevating active sites in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31341"
] | [
"Dictyostelium_Tiger"
] | [
542
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
98,
437,
7
] | 3 | [] | [] | 0 | true | Family | Dictyostelium Tiger | Dictyostelium Tiger | Dictyostelium_Tiger | 5 |
IPR052015 | 52,015 | Growth-differentiation transition regulator | GDT_regulator | Family | 38 | true | false | This family of proteins includes members that are involved in the regulation of the transition between growth and differentiation. Some proteins in this family are predicted to be serine/threonine-protein kinases, which suggests a role in phosphorylation-dependent signaling pathways. However, certain members are predic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47774"
] | [
"GDT_regulator"
] | [
38
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
38
] | 1 | [] | [] | 0 | true | Family | Growth-differentiation transition regulator | Growth-differentiation transition regulator | GDT_regulator | 8 |
IPR052016 | 52,016 | Bacterial Sigma Factor Regulator | Bact_Sigma-Reg | Family | 74,573 | true | false | The protein family described is involved in regulatory processes related to stress response and sporulation in bacteria. Members of the family function as regulators of sigma factors, which are proteins that control the transcription of specific sets of genes. They exhibit phosphatase activity, often dephosphorylating ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43156"
] | [
"Bact_Sigma-Reg"
] | [
74573
] | 1 | [] | [] | [] | 0 | [
"3eea",
"3es2",
"3f79",
"3ke6",
"3t91",
"3t9q",
"5mqh",
"5ucg",
"6k4e"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences",
"uncultured marine phage"
] | [
73991,
29,
123,
429,
1
] | 5 | [] | [] | 0 | true | Family | Bacterial Sigma Factor Regulator | Bacterial Sigma Factor Regulator | Bact_Sigma-Reg | 6 |
IPR052017 | 52,017 | 4-Toluene Sulfonate Uptake Permease | TSUP | Family | 45,000 | true | false | The 4-toluene sulfonate uptake permease (TSUP) family includes proteins involved in the transport of sulfonates and related compounds across cellular membranes. Members of the TSUP family are predominantly membrane transporters, which facilitate the uptake of substances like p-toluenesulphonate (TSA) and potentially ex... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30269"
] | [
"TSUP"
] | [
45000
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pandoravirus",
"unclassified sequences"
] | [
429,
43689,
227,
5,
650
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 4-Toluene Sulfonate Uptake Permease | 4-Toluene Sulfonate Uptake Permease | TSUP | 1 |
IPR052018 | 52,018 | PHP domain-containing protein | PHP_domain | Family | 25,862 | true | false | This family of proteins includes enzymes that are involved in nucleotide metabolism and RNA processing. Members of this family are capable of hydrolyzing phosphate esters, such as the hydrolysis of the phosphate ester at carbon-1 of 5-phospho-D-ribose 1,2-cyclic phosphate to form ribose 2,5-bisphosphate. Additionally, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42924"
] | [
"PHP_domain"
] | [
25862
] | 1 | [] | [] | [] | 0 | [
"2anu",
"2yb1",
"2yb4",
"3e0f",
"3e38",
"3o0f",
"7ug9",
"9etk"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1937,
22074,
2,
1170,
679
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
1,
4,
9
] | 4 | true | Family | PHP domain-containing protein | PHP domain-containing protein | PHP_domain | 5 |
IPR052019 | 52,019 | F420H(2)-dependent biliverdin reductase/Heme oxygenase | F420H2_bilvrd_red/Heme_oxyg | Family | 33,445 | true | false | The F420H(2)-dependent biliverdin reductase family is involved in the reduction of biliverdin to bilirubin, a potent antioxidant, which may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of infections such as M.tuberculosis. Some members are less efficient at this reaction, sugg... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35176"
] | [
"F420H2_bilvrd_red/Heme_oxyg"
] | [
33445
] | 1 | [] | [] | [] | 0 | [
"1rfe",
"1vl7",
"1w9a",
"1xxo",
"1y30",
"2aq6",
"2asf",
"3f7e",
"3gas",
"3swj",
"3tgv",
"4qvb",
"4zky",
"5jab",
"5jv4"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
890,
32128,
7,
420
] | 4 | [] | [] | 0 | true | Family | F420H(2)-dependent biliverdin reductase/Heme oxygenase | F420H(2)-dependent biliverdin reductase/Heme oxygenase | F420H2_bilvrd_red/Heme_oxyg | 9 |
IPR052020 | 52,020 | Cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases | Cyclic_di-GMP/3'3'-cGAMP_PDE | Family | 23,026 | true | false | This family of proteins includes cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases. They are involved in the hydrolysis of cyclic dinucleotides, such as cyclic diguanylate (c-di-GMP) and 3'3'-cyclic GMP-AMP (3'3'-cGAMP), to linear nucleotides. These enzymes play key roles in bacterial signaling pathways, regulat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45228"
] | [
"Cyclic_di-GMP/3'3'-cGAMP_PDE"
] | [
23026
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.1.4.-",
"PWY-5978",
"PWY-6129",
"PWY-6689",
"PWY-7119",
"PWY-7366"
] | [
"EC:3.1.4.-",
"METACYC:PWY-5978",
"METACYC:PWY-6129",
"METACYC:PWY-6689",
"METACYC:PWY-7119",
"METACYC:PWY-7366"
] | 6 | [
"4r8z",
"5z7c"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5,
22509,
21,
491
] | 4 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Family | Cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases | Cyclic di-GMP and 3'3'-cGAMP-specific phosphodiesterases | Cyclic_di-GMP/3'3'-cGAMP_PDE | 9 |
IPR052021 | 52,021 | Type I restriction system S subunit | Type-I_RS_S_subunit | Family | 24,212 | true | false | This family of proteins includes specificity subunits of type I restriction-modification systems. They are responsible for recognizing specific DNA sequences and directing the restriction-modification complex to these sites. The proteins contain DNA recognition domains that determine the sequence specificity for methyl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30408"
] | [
"Type-I_RS_S_subunit"
] | [
24212
] | 1 | [] | [] | [] | 0 | [
"1ydx",
"1yf2",
"7vru",
"7vs4",
"8vsq",
"8vsr"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
625,
23199,
26,
10,
352
] | 5 | [] | [] | 0 | true | Family | Type I restriction system S subunit | Type I restriction system S subunit | Type-I_RS_S_subunit | 1 |
IPR052022 | 52,022 | 26 kDa periplasmic antigen-related | 26kDa_periplasmic_antigen | Family | 20,422 | true | false | This family of proteins includes both characterized and uncharacterized members. The characterized proteins are known as 26 kDa periplasmic immunogenic proteins, which are likely involved in the immune response, possibly as antigens recognized by the host's immune system during infection. The uncharacterized proteins, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34387"
] | [
"26kDa_periplasmic_antigen"
] | [
20422
] | 1 | [] | [] | [] | 0 | [
"4hvz",
"7c50",
"7c51"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"metagenomes"
] | [
502,
19247,
370,
1,
302
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 26 kDa periplasmic antigen-related | 26 kDa periplasmic antigen-related | 26kDa_periplasmic_antigen | 9 |
IPR052023 | 52,023 | Sensor histidine kinase KdpD | Histidine_kinase_KdpD | Family | 18,607 | true | false | This family of proteins includes sensor histidine kinases known as KdpD, which are part of two-component regulatory systems, typically KdpD/KdpE. These proteins are involved in sensing environmental signals such as low potassium ion levels, osmotic imbalance, and other stresses. Upon sensing these signals, KdpD autopho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45569"
] | [
"Histidine_kinase_KdpD"
] | [
18607
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"2ksf",
"2r8r",
"4qpr",
"4y2f",
"6lgq",
"7ji4"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
18311,
20,
99,
177
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Sensor histidine kinase KdpD | Sensor histidine kinase KdpD | Histidine_kinase_KdpD | 6 |
IPR052024 | 52,024 | Methylcobamide/Methylated-thiol:CoM methyltransferase | Methanogen_methyltrans | Family | 8,062 | true | true | This family of proteins includes methyltransferases that play a crucial role in methanogenesis, a process of methane production in archaea. Members of this family are involved in transferring methyl groups from methylated corrinoid proteins or free cob(I)alamin to coenzyme M, which is a key step in the formation of the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47099"
] | [
"Methanogen_methyltrans"
] | [
8062
] | 1 | [] | [] | [] | 0 | [
"4ay7",
"4ay8"
] | 2 | [
"PUB00016082",
"PUB00063997",
"PUB00069753",
"PUB00161761",
"PUB00161762"
] | [
"10852929",
"23090404",
"9195968",
"11073950",
"7635826"
] | [
"Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.",
"Structure of the corrinoid:coenzyme M methyltransferase MtaA from Methanosarcina mazei.",
"Reconstitution of Monomethylamine:Coenzyme M methyl transfe... | [
2000,
2012,
1997,
2001,
1995
] | 5 | [] | [
"IPR048096"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
809,
6624,
12,
1,
616
] | 5 | [] | [] | 0 | true | Family | Methylcobamide/Methylated-thiol:CoM methyltransferase | Methylcobamide/Methylated-thiol:CoM methyltransferase | Methanogen_methyltrans | 1 |
IPR052026 | 52,026 | ExeA/AAA ATPase DNA-binding & secretion | ExeA_AAA_ATPase_DNA-bind | Family | 15,458 | true | false | The ExeA/AAA ATPase family includes proteins involved in various cellular processes such as general secretion pathways and DNA transposition. Members of the family may play regulatory roles in secretion systems, facilitating the export of proteins across membranes. Some proteins within the family function as ATP-depend... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35894"
] | [
"ExeA_AAA_ATPase_DNA-bind"
] | [
15458
] | 1 | [] | [] | [] | 0 | [
"7m99",
"7m9a",
"7m9b",
"7m9c",
"7n6i",
"7plh",
"7rzy",
"7svu",
"7svv",
"7ufi",
"7ufm",
"8bd4",
"8bd5",
"8bd6",
"8ea3",
"8ea4",
"8rdu",
"8rku",
"8xvb",
"8xvc",
"8xvd"
] | 21 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
242,
14724,
20,
116,
356
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ExeA/AAA ATPase DNA-binding & secretion | ExeA/AAA ATPase DNA-binding & secretion | ExeA_AAA_ATPase_DNA-bind | 7 |
IPR052027 | 52,027 | Phage shock protein C | PspC | Family | 18,460 | true | false | This family of proteins is involved in cellular stress response, particularly under conditions where nutrient or energy availability is limited. Members of this family are implicated in transcription regulation, possibly through the modulation of gene expression related to the phage shock protein (psp) operon. They may... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33885"
] | [
"PspC"
] | [
18460
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
201,
18098,
2,
2,
157
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phage shock protein C | Phage shock protein C | PspC | 6 |
IPR052028 | 52,028 | HipA Serine/Threonine-Protein Kinase | HipA_Ser/Thr_kinase | Family | 17,264 | true | false | The HipA Ser/Thr kinase family includes proteins that function as toxins within type II toxin-antitoxin (TA) systems. Members of the family phosphorylate Glu-tRNA-ligase, leading to an increase in uncharged tRNA(Glu), which triggers the stringent response and results in amino acid starvation. This process inhibits cell... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37419"
] | [
"HipA_Ser/Thr_kinase"
] | [
17264
] | 1 | [] | [] | [] | 0 | [
"2wiu",
"3dnt",
"3dnu",
"3dnv",
"3fbr",
"3hzi",
"3tpb",
"3tpd",
"3tpe",
"3tpt",
"3tpv",
"4pu3",
"4pu4",
"4pu5",
"4yg7",
"5k98",
"7ab3",
"7ab4",
"7ab5",
"7vkb",
"7vkc",
"7wcf",
"8ezr",
"8ezs"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"IncJ plasmid R391",
"Methanosarcinaceae",
"Siphoviridae sp. ctg0K17",
"unclassified sequences"
] | [
16858,
24,
1,
8,
2,
371
] | 6 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | HipA Serine/Threonine-Protein Kinase | HipA Serine/Threonine-Protein Kinase | HipA_Ser/Thr_kinase | 5 |
IPR052029 | 52,029 | Periplasmic chaperone PpiD | PpiD_chaperone | Family | 14,411 | true | false | The PpiD chaperone family comprises periplasmic chaperones that serve as gatekeepers at the SecYEG translocon, a protein-conducting channel in the bacterial inner membrane. Members of the family facilitate the translocation of precursor proteins across the SecYEG complex by interacting with substrates during translocat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47529"
] | [
"PpiD_chaperone"
] | [
14411
] | 1 | [] | [] | [] | 0 | [
"2kgj",
"8zht"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine group III euryarchaeote KM3-28-E8"
] | [
14088,
47,
275,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Periplasmic chaperone PpiD | Periplasmic chaperone PpiD | PpiD_chaperone | 1 |
IPR052030 | 52,030 | Peptidase M20/M20A family hydrolases | Peptidase_M20/M20A_hydrolases | Family | 19,095 | true | false | The peptidase M20 family is composed of enzymes that catalyze the hydrolysis of various substrates, including dipeptides and specific amino acid derivatives. Members of the peptidase M20A subfamily, such as Xaa-Arg dipeptidases, are involved in metabolite repair mechanisms, specifically by hydrolyzing dipeptides with b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30575"
] | [
"Peptidase_M20/M20A_hydrolases"
] | [
19095
] | 1 | [] | [] | [] | 0 | [
"3io1",
"3ram",
"7yh4",
"8xzc",
"8zei",
"8zel"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
764,
12551,
5460,
320
] | 4 | [
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
1,
1,
2,
3
] | 5 | true | Family | Peptidase M20/M20A family hydrolases | Peptidase M20/M20A family hydrolases | Peptidase_M20/M20A_hydrolases | 2 |
IPR052031 | 52,031 | Membrane Transporter and Flippase | Membrane_Transporter-Flippase | Family | 17,241 | true | false | This family of proteins includes transporters that are involved in various cellular transport processes. Some members are responsible for the extrusion of multiple antimicrobial compounds, contributing to multidrug resistance. These proteins typically function as antiporters, exchanging ions like H+ or Na+ for organic ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43549"
] | [
"Membrane_Transporter-Flippase"
] | [
17241
] | 1 | [] | [] | [] | 0 | [
"3vvn",
"3vvo",
"3vvp",
"3vvr",
"3vvs",
"3w4t",
"3wbn",
"4mlb",
"6fhz",
"6gwh",
"6hfb",
"6idp",
"6idr",
"6ids"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1146,
14889,
1017,
189
] | 4 | [] | [] | 0 | true | Family | Membrane Transporter and Flippase | Membrane Transporter and Flippase | Membrane_Transporter-Flippase | 2 |
IPR052033 | 52,033 | Glutaryl-CoA dehydrogenase | GCDH | Family | 17,450 | true | true | The Glutaryl-CoA dehydrogenase family is involved in the mitochondrial oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2, a crucial step in the catabolism of L-lysine, L-hydroxylysine, and L-tryptophan. Members of this family use electron transfer flavoprotein as an electron acceptor. The activity of th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42807"
] | [
"Glutaryl-CoA_DH_mitochondrial"
] | [
17450
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.8.6",
"R-BTA-71064",
"R-CEL-71064",
"R-DDI-71064",
"R-HSA-71064",
"R-MMU-71064"
] | [
"EC:1.3.8.6",
"REACTOME:R-BTA-71064",
"REACTOME:R-CEL-71064",
"REACTOME:R-DDI-71064",
"REACTOME:R-HSA-71064",
"REACTOME:R-MMU-71064"
] | 6 | [
"1siq",
"1sir",
"2eba",
"2r0m",
"2r0n",
"3d6b",
"3eom",
"3eon",
"3gnc",
"3gqt",
"3ii9",
"3sf6",
"3swo",
"4w9u"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
362,
12182,
4684,
222
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
4,
1,
36,
5,
1,
4
] | 7 | true | Family | Glutaryl-CoA dehydrogenase | Glutaryl-CoA dehydrogenase | GCDH | 7 |
IPR052034 | 52,034 | Nitrite reductase [NAD(P)H]-like | NasD-like | Family | 18,635 | true | true | This entry represents Nitrite reductase [NAD(P)H] from Bacillus subtilis [ ] and similar enzymes involved in nitrogen and sulfur metabolism from bacteria and fungi. Members of this family are responsible for the reduction of nitrite to ammonia, a step in nitrite assimilation, and the reduction of sulfite to sulfide, cr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43809"
] | [
"Nitrite/Sulfite_Rdtase_4Fe4S"
] | [
18635
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.7.1.4",
"PWY-5675",
"PWY-723"
] | [
"EC:1.7.1.4",
"METACYC:PWY-5675",
"METACYC:PWY-723"
] | 3 | [] | 0 | [
"PUB00014674"
] | [
"7868621"
] | [
"The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis."
] | [
1995
] | 1 | [] | [
"IPR017220"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
16620,
1693,
186,
136
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Family | Nitrite reductase [NAD(P)H]-like | Nitrite reductase [NAD(P)H]-like | NasD-like | 2 |
IPR052035 | 52,035 | Zinc finger BED domain-containing | ZnF_BED_domain_contain | Family | 43,797 | true | false | The Zinc finger BED domain-containing protein family includes transcriptional regulators that interact with DNA and RNA, often binding to poly-guanine tracts to activate transcription. Members are involved in various developmental processes, such as vulval organogenesis, cell cycle regulation, and gonadal development. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46481"
] | [
"ZnF_BED_domain_contain"
] | [
43797
] | 1 | [
"REACTOME"
] | [
"R-CEL-4551638"
] | [
"REACTOME:R-CEL-4551638"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pandoravirus",
"Pseudomonadota"
] | [
43776,
18,
3
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
73,
6,
34,
3,
1,
1,
184,
1,
79
] | 9 | true | Family | Zinc finger BED domain-containing | Zinc finger BED domain-containing | ZnF_BED_domain_contain | 7 |
IPR052036 | 52,036 | Hydrolase/Phosphoribosyltransferase-associated | Hydrolase/PRTase-associated | Family | 8,833 | true | false | This family of proteins includes enzymes with diverse hydrolytic activities. Some members are involved in the hydrolysis of the lactone ring of erythromycin, conferring resistance to this antibiotic. Other members are predicted to have phosphoribosyltransferase activity, which is typically associated with the synthesis... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31299"
] | [
"Hydrolase/PRTase-associated"
] | [
8833
] | 1 | [] | [] | [] | 0 | [
"2qgm",
"2rad",
"3b55",
"6xcq",
"6xcs"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
95,
7982,
723,
33
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Hydrolase/Phosphoribosyltransferase-associated | Hydrolase/Phosphoribosyltransferase-associated | Hydrolase/PRTase-associated | 5 |
IPR052037 | 52,037 | Lipopolysaccharide export system LptA | LPS_export_LptA | Family | 11,191 | true | false | This family of proteins is involved in the assembly and transport of lipopolysaccharide (LPS) across the bacterial cell envelope. Members of this family are essential for the translocation of LPS from the inner membrane to the outer membrane. They are believed to form a structural bridge between the inner and outer mem... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36504"
] | [
"LPS_export_LptA"
] | [
11191
] | 1 | [] | [] | [] | 0 | [
"2r19",
"2r1a",
"4uu4",
"6gd5",
"7qs6",
"7zax",
"7zed",
"8bss",
"8gaj",
"8gak",
"8gal",
"8onu"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11023,
6,
162
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Lipopolysaccharide export system LptA | Lipopolysaccharide export system LptA | LPS_export_LptA | 9 |
IPR052038 | 52,038 | Type VII TA system antitoxin | Type-VII_TA_antitoxin | Family | 9,115 | true | true | This family of proteins functions as antitoxins within type VII toxin-antitoxin (TA) systems. They act by neutralizing their cognate toxins through a modification process known as di-AMPylation. This post-translational modification involves the transfer of adenylyl groups to specific targets, which in the context of TA... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33571"
] | [
"Type-VII_TA_antitoxin"
] | [
9115
] | 1 | [
"EC"
] | [
"2.7.7.108"
] | [
"EC:2.7.7.108"
] | 1 | [
"1wot"
] | 1 | [] | [] | [] | [] | 0 | [] | [
"IPR009185"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
923,
7934,
8,
1,
249
] | 5 | [] | [] | 0 | true | Family | Type VII TA system antitoxin | Type VII TA system antitoxin | Type-VII_TA_antitoxin | 2 |
IPR052040 | 52,040 | GTPase and isobutyryl-CoA mutase domain-containing protein | GTPase/Isobutyryl-CoA_mutase | Family | 9,808 | true | false | This family of proteins includes GTPases with potential chaperone activity, involved in the assembly and repair of enzyme complexes. They may catalyze the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA using radical chemistry. Some members also exhibit ATPase activity and are involved in cofactor delive... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43087"
] | [
"GTPase/Isobutyryl-CoA_mutase"
] | [
9808
] | 1 | [] | [] | [] | 0 | [
"4xc6",
"4xc7",
"4xc8",
"5cjt",
"5cju",
"5cjv",
"5cjw",
"6cum",
"8ssl",
"8sta"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
584,
8880,
21,
323
] | 4 | [] | [] | 0 | true | Family | GTPase and isobutyryl-CoA mutase domain-containing protein | GTPase and isobutyryl-CoA mutase domain-containing protein | GTPase/Isobutyryl-CoA_mutase | 7 |
IPR052041 | 52,041 | Nucleic acid metabolism PIN/TRAM-domain-containing protein | Nucleic_acid_metab_PIN/TRAM | Family | 6,707 | true | false | This family of proteins is involved in nucleic acid metabolism, with some members functioning as ATP-dependent DNA helicases that promote Holliday junction branch migration and DNA unwinding. These proteins are implicated in DNA repair processes, particularly at low temperatures, and coordinate with other enzymes to fa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11603"
] | [
"Nucleic_acid_metab_PIN/TRAM"
] | [
6707
] | 1 | [] | [] | [] | 0 | [
"3i8o",
"5f4h",
"5yww"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
851,
4630,
1124,
102
] | 4 | [
"Caenorhabditis elegans",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
8,
1
] | 2 | true | Family | Nucleic acid metabolism PIN/TRAM-domain-containing protein | Nucleic acid metabolism PIN/TRAM-domain-containing protein | Nucleic_acid_metab_PIN/TRAM | 9 |
IPR052042 | 52,042 | Tail sheath structural protein | Tail_sheath_structural | Family | 13,100 | true | true | This family of proteins includes Tail sheath protein from Bacteriophage T4 [ ], the putative prophage major tail sheath protein from Pseudomonas aeruginosa [ ] and similar sequences from tailed bacteriophages and prokaryotic prophages that are involved in the assembly and structural integrity of bacteriophage tails. Me... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35861"
] | [
"Phage_Tail_Sheath_Structural"
] | [
13100
] | 1 | [] | [] | [] | 0 | [
"3j2m",
"3j2n",
"3j9q",
"3j9r",
"5w5e",
"6j0b",
"6j0c",
"6j0n",
"6pyt",
"6rao",
"6rap",
"6rbn",
"6rc8",
"6rgl",
"6u5b",
"6u5f",
"6u5j",
"6u5k",
"7adz",
"7ae0",
"7aeb",
"7aef",
"7aek",
"7b5h",
"7b5i",
"8bky",
"8bl4",
"8kee",
"9ev2",
"9ezm",
"9f4a",
"9gtp"... | 36 | [
"PUB00015589",
"PUB00160309"
] | [
"14625682",
"17038190"
] | [
"Structure and morphogenesis of bacteriophage T4.",
"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial."
] | [
2003,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
72,
11877,
48,
1019,
84
] | 5 | [] | [] | 0 | true | Family | Tail sheath structural protein | Tail sheath structural protein | Tail_sheath_structural | 1 |
IPR052043 | 52,043 | Polysaccharide Degradation Enzymes | PolySaccharide_Degr_Enz | Family | 14,019 | true | false | This family of proteins includes enzymes involved in the degradation of complex polysaccharides. Members of this family are characterized by their ability to hydrolyze specific glycosidic bonds within their respective substrates. Some act on unsaturated rhamnogalacturonan disaccharides, releasing unsaturated D-galactur... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33886"
] | [
"PolySaccharide_Degr_Enz"
] | [
14019
] | 1 | [] | [] | [] | 0 | [
"1nc5",
"2d8l",
"2gh4",
"3k11",
"3pmm",
"3qwt",
"4ce7",
"4q88",
"4wu0",
"4xuv",
"5noa"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Aureococcus anophagefferens virus",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
53,
1,
11056,
2817,
92
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Polysaccharide Degradation Enzymes | Polysaccharide Degradation Enzymes | PolySaccharide_Degr_Enz | 6 |
IPR052044 | 52,044 | Polyketide Synthase Associated Protein | PKS_Associated_Protein | Family | 8,936 | true | false | This family of proteins includes members involved in the biosynthesis of polyketides, a class of secondary metabolites with diverse structures and functions. The proteins in this family are associated with type II polyketide synthases (PKS), which are multi-enzyme complexes that catalyze the formation of polyketide cha... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36114"
] | [
"PKS_Associated_Protein"
] | [
8936
] | 1 | [] | [] | [] | 0 | [
"2i45",
"3d82"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
355,
8200,
260,
121
] | 4 | [] | [] | 0 | true | Family | Polyketide Synthase Associated Protein | Polyketide Synthase Associated Protein | PKS_Associated_Protein | 2 |
IPR052045 | 52,045 | Sulfur Carrier/Protein Modifier | Sulfur_Carrier/Prot_Modifier | Family | 8,238 | true | false | This family of proteins includes sulfur carrier components that are involved in cysteine biosynthesis and protein modification processes. In certain members, the thiocarboxylated form acts as a sulfur donor in a pathway dependent on CysM for cysteine production, which is crucial for survival in specific bacterial phase... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38031"
] | [
"Sulfur_Carrier/Prot_Modifier"
] | [
8238
] | 1 | [
"REACTOME"
] | [
"R-MTU-936654"
] | [
"REACTOME:R-MTU-936654"
] | 1 | [
"1v8c",
"2g1e",
"2k22",
"2l52",
"2m19",
"3dwg",
"3dwm",
"4n6e"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1077,
6891,
10,
260
] | 4 | [] | [] | 0 | true | Family | Sulfur Carrier/Protein Modifier | Sulfur Carrier/Protein Modifier | Sulfur_Carrier/Prot_Modifier | 9 |
IPR052046 | 52,046 | Glycosyl hydrolase family 57 | GH57 | Family | 5,125 | true | true | This family of proteins belongs to glycoside hydrolase family 57 which comprises enzymes with two known activities; alpha-amylase ( ) and 4-alpha-glucanotransferase ( ) [ , ]. Among them is amylopullulanase, a thermophilic endoamylase capable of hydrolyzing both alpha-1,4 and alpha-1,6-glycosidic bonds, which are inter... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36306"
] | [
"GH57_Enzymes"
] | [
5125
] | 1 | [
"EC"
] | [
"3.2.1.1"
] | [
"EC:3.2.1.1"
] | 1 | [
"1k1w",
"1k1x",
"1k1y",
"4cmr",
"7e1y",
"8zyi",
"9iht",
"9ihu",
"9ihv",
"9ihw",
"9ihx",
"9ii0",
"9ii1",
"9jlq",
"9jlr",
"9jls",
"9jlt",
"9jlu",
"9jlv",
"9jlw",
"9k7c",
"9k7d",
"9kyp",
"9kyq",
"9kyr"
] | 25 | [
"PUB00014074",
"PUB00161745"
] | [
"12618437",
"40419759"
] | [
"Crystal structures of 4-alpha-glucanotransferase from Thermococcus litoralis and its complex with an inhibitor.",
"The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad."
] | [
2003,
2025
] | 2 | [] | [
"IPR017002"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
654,
4267,
7,
197
] | 4 | [] | [] | 0 | true | Family | Glycosyl hydrolase family 57 | Glycosyl hydrolase family 57 | GH57 | 3 |
IPR052047 | 52,047 | Glycosyl Hydrolase 94 Enzymes | GH94_Enzymes | Family | 7,547 | true | false | This family of proteins includes enzymes that catalyze the reversible phosphorolysis of various glycosidic bonds. Members of this family are involved in the metabolism of carbohydrates such as beta-(1->2)-D-glucans, N,N'-diacetylchitobiose, cellobionic acid, and cellobiose. These enzymes function by breaking down these... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37469"
] | [
"GH94_Enzymes"
] | [
7547
] | 1 | [] | [] | [] | 0 | [
"1v7v",
"1v7w",
"1v7x",
"2cqs",
"2cqt",
"3acs",
"3act",
"3afj",
"3qde",
"3qfy",
"3qfz",
"3qg0",
"3rrs",
"3rsy",
"3s4a",
"3s4b",
"3s4c",
"3s4d",
"4zle",
"4zlf",
"4zlg",
"4zli",
"5h3z",
"5h40",
"5h41",
"5h42",
"5nz7",
"5nz8",
"6ggy",
"6gh2",
"6gh3",
"8bou"... | 47 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
26,
7129,
263,
129
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glycosyl Hydrolase 94 Enzymes | Glycosyl Hydrolase 94 Enzymes | GH94_Enzymes | 1 |
IPR052048 | 52,048 | Signal Transduction Response Regulator | ST_Response_Regulator | Family | 25,486 | true | false | This family of proteins includes response regulators that are integral to His-to-Asp phosphorelay signal transduction systems. They are phosphorylated on an Asp residue within a receiver domain, which activates their ability to regulate the transcription of target genes. Some members act as negative regulators of cytok... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43228"
] | [
"ST_Response_Regulator"
] | [
25486
] | 1 | [] | [] | [] | 0 | [
"1a0o",
"1ab5",
"1ab6",
"1bdj",
"1c4w",
"1cey",
"1chn",
"1cye",
"1d4z",
"1djm",
"1dz3",
"1e6k",
"1e6l",
"1e6m",
"1eay",
"1ehc",
"1f4v",
"1ffg",
"1ffs",
"1ffw",
"1fqw",
"1hey",
"1jbe",
"1kmi",
"1mih",
"1p6q",
"1p6u",
"1qmp",
"1tmy",
"1u0s",
"1u8t",
"1udr"... | 108 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"unclassified sequences"
] | [
966,
22250,
1899,
3,
368
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
1,
2,
4
] | 4 | true | Family | Signal Transduction Response Regulator | Signal Transduction Response Regulator | ST_Response_Regulator | 3 |
IPR052049 | 52,049 | Membrane-bound electron transfer protein | Electron_transfer_protein | Family | 7,676 | true | false | This family of proteins is involved in electron transfer processes within cellular respiration. Members are typically integral membrane components that interact with the quinone pool, facilitating the transfer of electrons to various terminal electron acceptors such as cytochrome c, menaquinol, tetrathionate, dimethyl ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34856"
] | [
"Electron_transfer_protein"
] | [
7676
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR005614"
] | [
"IPR017566",
"IPR053549"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
429,
7078,
169
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Membrane-bound electron transfer protein | Membrane-bound electron transfer protein | Electron_transfer_protein | 1 |
IPR052050 | 52,050 | Secreted Effector and Ankyrin Repeat | SecEffector_AnkRepeat | Family | 12,352 | true | false | This family of proteins includes secreted effectors with a role in host-pathogen interactions. One member is known to contain an RxLR-dEER motif, which is involved in the translocation of the effector into the host cell by binding to specific phospholipids on the cell surface. The same member is also implicated in the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46586"
] | [
"SecEffector_AnkRepeat"
] | [
12352
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota",
"Viruses",
"metagenomes"
] | [
10502,
167,
1539,
144
] | 4 | [] | [] | 0 | true | Family | Secreted Effector and Ankyrin Repeat | Secreted Effector and Ankyrin Repeat | SecEffector_AnkRepeat | 1 |
IPR052051 | 52,051 | T cell receptor complex component | TCR_complex_component | Family | 10,043 | true | false | This family of proteins includes components of the T cell receptor (TR) complex, which are crucial for the adaptive immune response. Members of this family are involved in recognizing peptide-major histocompatibility (MH) complexes displayed by antigen-presenting cells, a key step for T cell-mediated immunity against p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19433"
] | [
"TCR_complex_component"
] | [
10043
] | 1 | [] | [] | [] | 0 | [
"1kgc",
"1mi5",
"1oga",
"2bnq",
"2bnr",
"2bnu",
"2cde",
"2cdf",
"2cdg",
"2esv",
"2eyr",
"2eys",
"2eyt",
"2f53",
"2f54",
"2p5e",
"2p5w",
"2po6",
"2pye",
"2pyf",
"2q86",
"2qhl",
"2qjd",
"2qqq",
"2qte",
"2vlj",
"2vlk",
"2vlm",
"2vlr",
"2xn9",
"2xna",
"3arb"... | 273 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Gnathostomata"
] | [
3,
10040
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
141,
17,
3,
5
] | 4 | true | Family | T cell receptor complex component | T cell receptor complex component | TCR_complex_component | 7 |
IPR052052 | 52,052 | Polysaccharide Lyase 9 | Polysaccharide_Lyase_9 | Family | 6,794 | true | false | The Polysaccharide Lyase 9 family includes enzymes with pectate lyase activity, which are involved in the degradation of pectin, a component of the plant cell wall. Members of this family exhibit endo-cleaving activity on homogalacturonan, a region in pectin, and can also act on partially methylated pectin. They releas... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40088"
] | [
"Polysaccharide_Lyase_9"
] | [
6794
] | 1 | [
"EC"
] | [
"4.2.2.2"
] | [
"EC:4.2.2.2"
] | 1 | [
"1ru4",
"3vst",
"3vsu",
"3vsv",
"5olq",
"5olr",
"5ols"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage SP-15",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
50,
1,
5986,
697,
60
] | 5 | [] | [] | 0 | true | Family | Polysaccharide Lyase 9 | Polysaccharide Lyase 9 | Polysaccharide_Lyase_9 | 5 |
IPR052053 | 52,053 | Inner Membrane YidH-like | IM_YidH-like | Family | 9,414 | true | false | This family of proteins is involved in cellular processes associated with the inner membrane, as suggested by the name 'Inner membrane protein YidH'. The exact functions of these proteins are not clearly defined in the provided annotations. However, the similarity to proteins from different species, such as M.tuberculo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34187"
] | [
"IM_YidH-like"
] | [
9414
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
57,
5244,
4087,
26
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
3
] | 2 | true | Family | Inner Membrane YidH-like | Inner Membrane YidH-like | IM_YidH-like | 9 |
IPR052054 | 52,054 | Oxidative DNA damage repair enzyme | Oxidative_DNA_repair_enzyme | Family | 7,625 | true | false | This family of proteins is involved in the cellular response to oxidative DNA damage. Members of this family function as DNA repair enzymes that recognize and excise oxidized DNA bases, specifically 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY). They exhibit a beta-lya... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10242"
] | [
"Oxidative_DNA_repair_enzyme"
] | [
7625
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.2.2.-",
"4.2.99.18",
"PWY-2681",
"PWY-5316",
"PWY-5381",
"PWY-7342",
"PWY-7564",
"PWY-8106",
"R-DME-110329",
"R-DME-110330",
"R-DME-110331",
"R-DME-110357",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-110357",
"R-HSA-5649702",
"R-HSA-9656255",
"R-H... | [
"EC:3.2.2.-",
"EC:4.2.99.18",
"METACYC:PWY-2681",
"METACYC:PWY-5316",
"METACYC:PWY-5381",
"METACYC:PWY-7342",
"METACYC:PWY-7564",
"METACYC:PWY-8106",
"REACTOME:R-DME-110329",
"REACTOME:R-DME-110330",
"REACTOME:R-DME-110331",
"REACTOME:R-DME-110357",
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA... | 34 | [
"1ebm",
"1fn7",
"1hu0",
"1ko9",
"1lwv",
"1lww",
"1lwy",
"1m3h",
"1m3q",
"1n39",
"1n3a",
"1n3c",
"1yqk",
"1yql",
"1yqm",
"1yqr",
"2i5w",
"2nob",
"2noe",
"2nof",
"2noh",
"2noi",
"2nol",
"2noz",
"2xhi",
"3f0z",
"3f10",
"3i0w",
"3i0x",
"3ih7",
"3ktu",
"4ejy"... | 73 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
616,
1466,
5463,
80
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
3,
3,
3,
17,
4,
1,
7,
5,
1,
4
] | 10 | true | Family | Oxidative DNA damage repair enzyme | Oxidative DNA damage repair enzyme | Oxidative_DNA_repair_enzyme | 8 |
IPR052055 | 52,055 | Hepadnavirus polymerase/reverse transcriptase | Hepadnavirus_pol/RT | Family | 15,943 | true | false | This family of proteins includes multifunctional enzymes that play a crucial role in the replication of hepadnaviruses by converting the viral RNA genome into double-stranded DNA within cytoplasmic capsids. These enzymes exhibit both DNA polymerase activity, which can utilize DNA or RNA templates, and ribonuclease H ac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33050"
] | [
"Hepadnavirus_pol/RT"
] | [
15943
] | 1 | [
"EC",
"EC",
"EC"
] | [
"2.7.7.49",
"2.7.7.7",
"3.1.26.4"
] | [
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.1.26.4"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Revtraviricetes",
"organismal metagenomes"
] | [
6,
13593,
2335,
9
] | 4 | [
"Danio rerio"
] | [
10
] | 1 | true | Family | Hepadnavirus polymerase/reverse transcriptase | Hepadnavirus polymerase/reverse transcriptase | Hepadnavirus_pol/RT | 5 |
IPR052056 | 52,056 | Mono-ADP-ribosyltransferase ARTD/PARP | Mono-ARTD/PARP | Family | 8,274 | true | false | This family of proteins includes mono-ADP-ribosyltransferases that are involved in various cellular processes, including DNA damage repair, immune responses, and regulation of transcription. Members of this family are capable of mediating mono-ADP-ribosylation of target proteins, which is a post-translational modificat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14453"
] | [
"Mono-ARTD/PARP"
] | [
8274
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.-",
"PWY-5381",
"PWY-5800",
"PWY-6148",
"PWY-6720",
"PWY-7018",
"PWY-7025",
"PWY-7450",
"PWY-7817",
"PWY-7981",
"R-HSA-196807",
"R-HSA-9683610",
"R-HSA-9694631"
] | [
"EC:2.4.2.-",
"METACYC:PWY-5381",
"METACYC:PWY-5800",
"METACYC:PWY-6148",
"METACYC:PWY-6720",
"METACYC:PWY-7018",
"METACYC:PWY-7025",
"METACYC:PWY-7450",
"METACYC:PWY-7817",
"METACYC:PWY-7981",
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9683610",
"REACTOME:R-HSA-9694631"
] | 13 | [
"3blj",
"3gey",
"3goy",
"3hkv",
"3q6z",
"3q71",
"3se2",
"3smi",
"3smj",
"3v2b",
"3vfq",
"4abk",
"4abl",
"4d86",
"4f0e",
"4f1l",
"4f1q",
"4py4",
"5ail",
"5lx6",
"5lxp",
"5lyh",
"5nqe",
"5o2d",
"5qht",
"5qhu",
"5qhv",
"5qhw",
"5qhx",
"5qhy",
"5qhz",
"5qi0"... | 103 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
115,
8150,
2,
7
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
20,
7,
9
] | 4 | true | Family | Mono-ADP-ribosyltransferase ARTD/PARP | Mono-ADP-ribosyltransferase ARTD/PARP | Mono-ARTD/PARP | 5 |
IPR052057 | 52,057 | IS150/IS1296 orfA-like | IS150/IS1296_orfA-like | Family | 6,983 | true | false | This family of proteins is associated with mobile genetic elements known as insertion sequences (IS). Members of this family are typically involved in the transposition process, which allows the IS elements to move within the genome. The proteins may possess functions such as DNA binding, endonuclease activity, and/or ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33795"
] | [
"IS150/IS1296_orfA-like"
] | [
6983
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
6915,
2,
6,
7,
53
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | IS150/IS1296 orfA-like | IS150/IS1296 orfA-like | IS150/IS1296_orfA-like | 1 |
IPR052058 | 52,058 | Alcohol O-acetyltransferase-related protein | Alcohol_O-acetyltransferase | Family | 7,836 | true | false | This family of proteins includes enzymes that are involved in the acetylation of alcohols using acetyl-CoA, producing various acetate esters. These esters can have roles in detoxification processes, interaction with insect vectors for dispersal, and resistance to inhibitors of sphingolipid biosynthesis. Some members ar... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28037"
] | [
"Alcohol_O-acetyltransferase"
] | [
7836
] | 1 | [] | [] | [] | 0 | [
"8s6l"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
38,
2236,
5547,
15
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4,
1
] | 3 | true | Family | Alcohol O-acetyltransferase-related protein | Alcohol O-acetyltransferase-related protein | Alcohol_O-acetyltransferase | 7 |
IPR052059 | 52,059 | Cysteine-rich Ser/Thr receptor-like kinase | CR_Ser/Thr_kinase | Family | 15,680 | true | false | This family of proteins includes serine/threonine kinases that are characterized by cysteine-rich sequences. Members are involved in various signaling pathways and cellular processes. One member is known to be activated by cold and acts as a negative regulator of freezing tolerance by phosphorylating specific target pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47973"
] | [
"CR_Ser/Thr_kinase"
] | [
15680
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11",
"R-DME-214842",
"R-DME-214844",
"R-DME-214862",
"R-DME-214869",
"R-DME-214874",
"R-DME-445989",
"R-DME-450302",
"R-DME-450321",
"R-DME-9020702",
"R-DME-937039",
"R-DME-937042",
"R-DME-937072",
"R-DME-975144",
"R-DME-975163"
] | [
"EC:2.7.11",
"REACTOME:R-DME-214842",
"REACTOME:R-DME-214844",
"REACTOME:R-DME-214862",
"REACTOME:R-DME-214869",
"REACTOME:R-DME-214874",
"REACTOME:R-DME-445989",
"REACTOME:R-DME-450302",
"REACTOME:R-DME-450321",
"REACTOME:R-DME-9020702",
"REACTOME:R-DME-937039",
"REACTOME:R-DME-937042",
"RE... | 15 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
15680
] | 1 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
49,
2,
98,
156
] | 4 | true | Family | Cysteine-rich Ser/Thr receptor-like kinase | Cysteine-rich Ser/Thr receptor-like kinase | CR_Ser/Thr_kinase | 1 |
IPR052060 | 52,060 | Bromodomain and WD repeat-containing | Bromo_WD_repeat | Family | 8,523 | true | false | The Bromodomain and WD repeat-containing protein family is involved in various cellular processes including the regulation of cell morphology, cytoskeletal organization, and control of cell shape. Members of this family may function as transcriptional activators and could be implicated in chromatin remodeling. Some pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16266"
] | [
"Bromo_WD_repeat"
] | [
8523
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-1266695",
"R-DDI-3247509",
"R-DDI-9013418",
"R-HSA-1266695",
"R-HSA-3247509",
"R-HSA-9013418",
"R-MMU-1266695",
"R-MMU-3247509",
"R-MMU-9013418"
] | [
"REACTOME:R-DDI-1266695",
"REACTOME:R-DDI-3247509",
"REACTOME:R-DDI-9013418",
"REACTOME:R-HSA-1266695",
"REACTOME:R-HSA-3247509",
"REACTOME:R-HSA-9013418",
"REACTOME:R-MMU-1266695",
"REACTOME:R-MMU-3247509",
"REACTOME:R-MMU-9013418"
] | 9 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Tenacibaculum"
] | [
8521,
2
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
25,
7,
2,
24,
19,
5,
17,
21
] | 8 | true | Family | Bromodomain and WD repeat-containing | Bromodomain and WD repeat-containing | Bromo_WD_repeat | 1 |
IPR052061 | 52,061 | Post-transcriptional expression and antimicrobial biosynthesis protein | PTE-AB_protein | Family | 6,543 | true | false | This family of proteins includes components involved in various cellular processes, including post-transcriptional gene expression and biosynthesis of bioactive compounds. Some members are part of large complexes that coordinate ribosomal functions with gene expression steps. Others are implicated in the production of ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47260"
] | [
"PTE-AB_protein"
] | [
6543
] | 1 | [] | [] | [] | 0 | [
"3nwz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Microviridae sp. ctNWS1",
"Promethearchaeaceae",
"metagenomes"
] | [
1186,
5334,
1,
2,
20
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
2,
3
] | 3 | true | Family | Post-transcriptional expression and antimicrobial biosynthesis protein | Post-transcriptional expression and antimicrobial biosynthesis protein | PTE-AB_protein | 1 |
IPR052062 | 52,062 | Murein DD-endopeptidase/LD-carboxypeptidase | Murein_DD/LD_carboxypeptidase | Family | 6,841 | true | false | This family of proteins includes enzymes with murein DD-endopeptidase activity, which specifically target D-Ala-meso-diaminopimelic acid (mDAP) cross-links within bacterial cell walls. Their primary function is to facilitate cell wall expansion by cleaving these cross-links, allowing for the insertion of new glycan str... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47360"
] | [
"Murein_DD/LD_carboxypeptidase"
] | [
6841
] | 1 | [] | [] | [] | 0 | [
"2k1g",
"4xcm",
"7v6s",
"7v6t",
"7v6u",
"8i2e",
"8xud",
"8xup"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
6808,
2,
4,
27
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Murein DD-endopeptidase/LD-carboxypeptidase | Murein DD-endopeptidase/LD-carboxypeptidase | Murein_DD/LD_carboxypeptidase | 6 |
IPR052063 | 52,063 | Polysaccharide Lyase 1 | Polysaccharide_Lyase_1 | Family | 5,157 | true | false | The Polysaccharide Lyase 1 family includes pectinolytic enzymes that play a crucial role in the degradation of pectin, a plant cell wall polysaccharide. Members of the family are characterized by their ability to cleave internal glycosidic bonds in highly methylated pectins, a process that is essential for the breakdow... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42970"
] | [
"Polysaccharide_Lyase_1"
] | [
5157
] | 1 | [
"EC"
] | [
"4.2.2.2"
] | [
"EC:4.2.2.2"
] | 1 | [
"9buj"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
4202,
6,
775,
107,
67
] | 5 | [] | [] | 0 | true | Family | Polysaccharide Lyase 1 | Polysaccharide Lyase 1 | Polysaccharide_Lyase_1 | 8 |
IPR052064 | 52,064 | Mitochondrial Inner Membrane Protease Subunit 1 | Mito_IMP1_subunit | Family | 6,543 | true | false | The Mitochondrial Inner Membrane Protease (IMP) Subunit 1 family comprises enzymes that play a crucial role in the maturation of mitochondrial proteins. Members of this family are responsible for catalyzing the removal of transit peptides from precursor proteins that are targeted from the mitochondrial matrix, across t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12383"
] | [
"Mito_IMP1_subunit"
] | [
6543
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Naiadarchaeum limnaeum",
"Eukaryota",
"Myoviridae sp. ctgXL3",
"ecological metagenomes"
] | [
1537,
1,
4967,
1,
37
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
3,
4,
6,
1,
1,
4,
6,
1,
1,
16
] | 12 | true | Family | Mitochondrial Inner Membrane Protease Subunit 1 | Mitochondrial Inner Membrane Protease Subunit 1 | Mito_IMP1_subunit | 1 |
IPR052065 | 52,065 | Complement and asymmetry regulator | Compl_asym_regulator | Family | 6,865 | true | false | This family of proteins includes regulators of the alternate pathway of complement. Members are characterized by their ability to bind and stabilize C3- and C5-convertase enzyme complexes, thereby playing a crucial role in the innate immune response. They are also involved in inhibiting the degradation of the Complemen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22906"
] | [
"Compl_asym_regulator"
] | [
6865
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-173736",
"R-HSA-174577",
"R-HSA-5083635",
"R-HSA-5173214",
"R-HSA-6798695",
"R-HSA-977606",
"R-MMU-173736",
"R-MMU-174577",
"R-MMU-5173214",
"R-MMU-6798695",
"R-MMU-977606"
] | [
"REACTOME:R-HSA-173736",
"REACTOME:R-HSA-174577",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-173736",
"REACTOME:R-MMU-174577",
"REACTOME:R-MMU-5173214",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-977606"
] | 11 | [
"1w0r",
"1w0s",
"4v2a",
"6ool",
"6rur",
"6rus",
"6ruv",
"6rv6",
"6s08",
"6s0a",
"6s0b",
"6sej",
"7b26",
"7noz",
"7r84",
"7r85",
"7r86",
"8ckg",
"8ckk",
"8ckl",
"8ckm",
"8q6r"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
30,
6833,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
9,
5,
4
] | 5 | true | Family | Complement and asymmetry regulator | Complement and asymmetry regulator | Compl_asym_regulator | 7 |
IPR052066 | 52,066 | Glycosphingolipid Hydrolyzing Enzymes | Glycosphingolipid_Hydrolases | Family | 5,968 | true | false | This family of proteins is involved in the hydrolysis of glycosidic linkages in various glycosphingolipids. Members exhibit a range of substrate specificities, with some acting on glycosphingolipids with gangliotetraose structures and others on glucosylceramide. They play roles in the catabolism of complex lipids, prev... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31308"
] | [
"Glycosphingolipid_Hydrolases"
] | [
5968
] | 1 | [
"EC"
] | [
"3.2.1"
] | [
"EC:3.2.1"
] | 1 | [
"2osw",
"2osx",
"2osy",
"2oyk",
"2oyl",
"2oym",
"5ccu",
"5j14",
"5j7z",
"6jyz",
"7lpo",
"7lpp",
"7lpq",
"8exd"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nitrosocosmicus oleophilus",
"Eukaryota",
"metagenomes"
] | [
1909,
1,
4038,
20
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Glycosphingolipid Hydrolyzing Enzymes | Glycosphingolipid Hydrolyzing Enzymes | Glycosphingolipid_Hydrolases | 5 |
IPR052067 | 52,067 | Metal-responsive HTH-type transcriptional regulators | Metal_resp_HTH_trans_reg | Family | 5,964 | true | false | The protein family includes transcriptional regulators that respond to environmental stimuli such as metal ions, specifically zinc, to regulate gene expression. Members of the family act as repressors or activators by binding to specific DNA motifs in the promoter regions of target genes. They are involved in various b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35790"
] | [
"Metal_resp_HTH_trans_reg"
] | [
5964
] | 1 | [] | [] | [] | 0 | [
"1lnw",
"2fa5",
"3ech",
"3mex",
"3tgn",
"4zzl",
"5jls",
"5jlu",
"5yhx",
"5yhy",
"5yhz",
"5yi0",
"5yi1",
"5yi2",
"5yi3",
"6fi9"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Sym plasmid",
"metagenomes"
] | [
5897,
6,
36,
1,
24
] | 5 | [] | [] | 0 | true | Family | Metal-responsive HTH-type transcriptional regulators | Metal-responsive HTH-type transcriptional regulators | Metal_resp_HTH_trans_reg | 1 |
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