interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051841 | 51,841 | Microtubule and Golgi organization protein | MT-Golgi_org_protein | Family | 6,360 | true | false | This family of proteins is involved in the organization and maintenance of cellular structures and processes. Members function in the formation and stabilization of microtubules, which are critical for mitotic spindle formation, chromosome alignment and segregation, and spindle pole establishment during cell division. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR18902"
] | [
"MT-Golgi_org_protein"
] | [
6360
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-6811440",
"R-HSA-68875",
"R-HSA-8854518",
"R-HSA-9696270",
"R-HSA-9725370",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-6811440",
"REACTOME:R-HSA-68875",
"REACTOME:R-HSA-8854518",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9725370",
"REACTOME:R-MM... | 22 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloarcula salina"
] | [
7,
6352,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
14,
51,
25,
19
] | 5 | true | Family | Microtubule and Golgi organization protein | Microtubule and Golgi organization protein | MT-Golgi_org_protein | 9 |
IPR051842 | 51,842 | Ribosomal subunit uS12 prolyl hydroxylase | uS12_prolyl_hydroxylase | Family | 5,220 | true | false | This family of proteins includes prolyl 3-hydroxylases and prolyl 3,4-dihydroxylases that are involved in the post-translational modification of the small ribosomal subunit protein uS12. The hydroxylation of a specific proline residue within uS12 is crucial for regulating the efficiency of protein translation terminati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12117"
] | [
"uS12_prolyl_hydroxylase"
] | [
5220
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.14.11.-",
"PWY-102",
"PWY-1187",
"PWY-5035",
"PWY-5036",
"PWY-5047",
"PWY-5070",
"PWY-5349",
"PWY-6085",
"PWY-6086",
"PWY-6495",
"PWY-6682",
"PWY-6915",
"PWY-6919",
"PWY-7150",
"PWY-7151",
"PWY-7232",
"PWY-7274",
"PWY-7298",
"PWY-7398",
"PWY-7419",
"PWY-7517",
"PWY-764... | [
"EC:1.14.11.-",
"METACYC:PWY-102",
"METACYC:PWY-1187",
"METACYC:PWY-5035",
"METACYC:PWY-5036",
"METACYC:PWY-5047",
"METACYC:PWY-5070",
"METACYC:PWY-5349",
"METACYC:PWY-6085",
"METACYC:PWY-6086",
"METACYC:PWY-6495",
"METACYC:PWY-6682",
"METACYC:PWY-6915",
"METACYC:PWY-6919",
"METACYC:PWY-... | 41 | [
"3kt1",
"3kt4",
"3kt7",
"3mgu",
"4nhk",
"4nhl",
"4nhm",
"4nhx",
"4nhy",
"6e0t",
"9blq"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
14,
1102,
4067,
6,
31
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
1,
7,
2,
1,
8,
1,
1
] | 9 | true | Family | Ribosomal subunit uS12 prolyl hydroxylase | Ribosomal subunit uS12 prolyl hydroxylase | uS12_prolyl_hydroxylase | 1 |
IPR051843 | 51,843 | Monovalent cation:proton antiporter 1 | CPA1_transporter | Family | 5,463 | true | false | This family of proteins functions as electroneutral Na(+)/H(+) antiporters that exchange sodium or lithium ions for protons across cellular membranes. They utilize the proton gradient and membrane potential to extrude sodium, contributing to intracellular pH and sodium homeostasis. Members of this family are involved i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31102"
] | [
"CPA1_transporter"
] | [
5463
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2672351",
"R-MMU-2672351",
"R-XTR-2672351"
] | [
"REACTOME:R-HSA-2672351",
"REACTOME:R-MMU-2672351",
"REACTOME:R-XTR-2672351"
] | 3 | [
"7b4l",
"7b4m",
"7p1i",
"7p1j",
"7p1k",
"9qub",
"9quw"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriaceae",
"Myoviridae sp. ctLjW1",
"metagenomes"
] | [
978,
4442,
23,
1,
19
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
6,
14,
6,
8
] | 6 | true | Family | Monovalent cation:proton antiporter 1 | Monovalent cation:proton antiporter 1 | CPA1_transporter | 3 |
IPR051844 | 51,844 | Sensory Perception USH2 Complex Protein | USH2_Complex_Protein | Family | 5,925 | true | false | This family of proteins is involved in sensory perception, particularly in hearing and vision. Members of this family play a crucial role in the formation and maintenance of the USH2 complex, which is essential for the proper function of hair cells in the inner ear. They are necessary for the elongation and maintenance... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23116"
] | [
"USH2_Complex_Protein"
] | [
5925
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9662360",
"R-HSA-9662361"
] | [
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361"
] | 2 | [
"1uez",
"1uf1",
"1ufx",
"1v6b",
"1x5n",
"2eeh",
"2kbq",
"2kbr",
"2kbs",
"2lsr",
"3k1r",
"5f3x",
"5mv8",
"5mv9",
"5xbf",
"6fdd",
"6fde",
"6kz1",
"6y38",
"6y9n",
"6y9o",
"6y9p",
"6y9q",
"7de7",
"7weg",
"7x2e"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5925
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
33,
12,
15,
17,
14
] | 5 | true | Family | Sensory Perception USH2 Complex Protein | Sensory Perception USH2 Complex Protein | USH2_Complex_Protein | 2 |
IPR051845 | 51,845 | Zinc finger protein 385 | Znf385 | Family | 5,672 | true | false | The Zinc finger protein 385 family is involved in various cellular processes, including apoptosis, mRNA localization and translation, cell cycle arrest, and differentiation. Members of this family may influence p53/TP53-mediated apoptosis and have roles in RNA-binding that affect mRNA translation and localization, such... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23067"
] | [
"Znf385"
] | [
5672
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6804114",
"R-HSA-6804116",
"R-HSA-6804759",
"R-HSA-69895",
"R-MMU-6804759",
"R-MMU-69895"
] | [
"REACTOME:R-HSA-6804114",
"REACTOME:R-HSA-6804116",
"REACTOME:R-HSA-6804759",
"REACTOME:R-HSA-69895",
"REACTOME:R-MMU-6804759",
"REACTOME:R-MMU-69895"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
5672
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
26,
26,
8,
28
] | 4 | true | Family | Zinc finger protein 385 | Zinc finger protein 385 | Znf385 | 7 |
IPR051846 | 51,846 | SH2 domain-containing adapter proteins | SH2_domain_adapters | Family | 5,202 | true | false | This family of proteins includes SH2 domain-containing adapter proteins involved in various signal transduction pathways. They function as intermediaries that connect activated receptors to downstream signaling molecules. These proteins play crucial roles in processes such as angiogenesis, T-cell antigen receptor signa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15127"
] | [
"SH2_domain_adapters"
] | [
5202
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-4420097",
"R-MMU-4420097"
] | [
"REACTOME:R-HSA-4420097",
"REACTOME:R-MMU-4420097"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrosopumilus oxyclinae",
"metagenomes"
] | [
323,
4865,
1,
13
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
14,
9,
23,
12,
16
] | 6 | true | Family | SH2 domain-containing adapter proteins | SH2 domain-containing adapter proteins | SH2_domain_adapters | 1 |
IPR051847 | 51,847 | RNA Processing and Spliceosome Component | RNA_proc/Spliceosome_comp | Family | 5,521 | true | false | This family of proteins includes members that are involved in various aspects of RNA processing, particularly pre-mRNA splicing. Some proteins in this family act as components of the spliceosome, a complex responsible for the removal of introns from pre-mRNA transcripts. They may participate in the assembly of the spli... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45880"
] | [
"RNA_proc/Spliceosome_comp"
] | [
5521
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 3 | [
"2mkc",
"2my2",
"2my3",
"3lqv",
"4uqt",
"5gm6",
"5lqw",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ff4",
"6ff7",
"7abh",
"7abi",
"7dco",
"7dvq",
"8i0p",
"8i0r"
] | 20 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
5505,
16
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
2,
1,
5,
2,
1,
1,
2,
1,
1,
6
] | 12 | true | Family | RNA Processing and Spliceosome Component | RNA Processing and Spliceosome Component | RNA_proc/Spliceosome_comp | 7 |
IPR051848 | 51,848 | Polygalacturonase-Inhibiting Protein | PGIP | Family | 7,412 | true | false | This family of proteins includes inhibitors of fungal polygalacturonase, which are key components in plant defense against phytopathogenic fungi. Members of this family are involved in the inhibition of a range of polygalacturonases from different fungal species, contributing to the plant's resistance mechanisms. Some ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48059"
] | [
"PGIP"
] | [
7412
] | 1 | [] | [] | [] | 0 | [
"1ogq",
"8ikw"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
380,
7010,
22
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
49,
43,
53
] | 3 | true | Family | Polygalacturonase-Inhibiting Protein | Polygalacturonase-Inhibiting Protein | PGIP | 4 |
IPR051849 | 51,849 | Glycosaminoglycan-degrading sulfatase | GAG-degrading_sulfatase | Family | 3,595 | true | false | This family of proteins includes enzymes with sulfatase activity, which are involved in the degradation of glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, and heparan sulfate. They catalyze the hydrolysis of sulfate groups, particularly the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues. The... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46615"
] | [
"GAG-degrading_sulfatase"
] | [
3595
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.6.1",
"3.1.6.18",
"R-BTA-1663150",
"R-BTA-9840310",
"R-CFA-1663150",
"R-CFA-9840310",
"R-HSA-1663150",
"R-HSA-9840310",
"R-MMU-1663150",
"R-MMU-9840310",
"R-RNO-1663150",
"R-RNO-9840310"
] | [
"EC:3.1.6.1",
"EC:3.1.6.18",
"REACTOME:R-BTA-1663150",
"REACTOME:R-BTA-9840310",
"REACTOME:R-CFA-1663150",
"REACTOME:R-CFA-9840310",
"REACTOME:R-HSA-1663150",
"REACTOME:R-HSA-9840310",
"REACTOME:R-MMU-1663150",
"REACTOME:R-MMU-9840310",
"REACTOME:R-RNO-1663150",
"REACTOME:R-RNO-9840310"
] | 12 | [
"3b5q",
"5g2t",
"5g2u"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Imitervirales",
"unclassified sequences"
] | [
28,
2241,
1177,
6,
143
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
2,
2
] | 4 | true | Family | Glycosaminoglycan-degrading sulfatase | Glycosaminoglycan-degrading sulfatase | GAG-degrading_sulfatase | 5 |
IPR051851 | 51,851 | EFR3 Homologs | EFR3_Homologs | Family | 4,992 | true | false | This family of proteins is involved in the regulation of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. Members of this family are components of a complex that is required for the localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Within this complex, these proteins likely serve as t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12444"
] | [
"EFR3_Homologs"
] | [
4992
] | 1 | [] | [] | [] | 0 | [
"9bax"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4992
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
24,
4,
11,
8,
7
] | 6 | true | Family | EFR3 Homologs | EFR3 Homologs | EFR3_Homologs | 7 |
IPR051852 | 51,852 | Alpha-type Protein Kinase | Alpha-type_PK | Family | 5,171 | true | false | This family of proteins includes threonine kinases that play a role in regulating protein synthesis and myosin II filament assembly. Members are involved in phosphorylating specific threonine residues, which is crucial for controlling the rate of peptide chain elongation during protein synthesis or for the assembly and... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45992"
] | [
"Alpha-type_PK"
] | [
5171
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11",
"R-CEL-166208",
"R-DDI-166208",
"R-HSA-166208",
"R-MMU-166208",
"R-RNO-166208"
] | [
"EC:2.7.11",
"REACTOME:R-CEL-166208",
"REACTOME:R-DDI-166208",
"REACTOME:R-HSA-166208",
"REACTOME:R-MMU-166208",
"REACTOME:R-RNO-166208"
] | 6 | [
"1ia9",
"1iah",
"1iaj",
"3lkm",
"3lla",
"3lmh",
"3lmi",
"3pdt",
"4kuj",
"4nl0",
"4zme",
"4zmf",
"4zs4",
"5dyj",
"5e4h",
"5e9e",
"6nx4",
"7shq",
"8fny",
"8fo6",
"8gm4",
"8gm5"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactobacillus gasseri",
"Methanobrevibacter filiformis"
] | [
5169,
1,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
5,
7,
6
] | 5 | true | Family | Alpha-type Protein Kinase | Alpha-type Protein Kinase | Alpha-type_PK | 7 |
IPR051853 | 51,853 | Adapter protein with SH2 and Ras-GEF domains | SH2-Ras-GEF_adapter | Family | 4,905 | true | false | This family of proteins functions as adapter molecules in various signaling pathways, particularly those involving growth factor receptors. They are involved in promoting cellular processes such as proliferation, migration, and actin cytoskeleton reorganization. These proteins mediate the activation of MAPK signaling a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14247"
] | [
"SH2-Ras-GEF_adapter"
] | [
4905
] | 1 | [] | [] | [] | 0 | [
"1wqu",
"2dcr",
"2kk6",
"3t6a",
"3t6g",
"6kc4",
"7t1k"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4905
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
3,
15,
6,
9
] | 5 | true | Family | Adapter protein with SH2 and Ras-GEF domains | Adapter protein with SH2 and Ras-GEF domains | SH2-Ras-GEF_adapter | 9 |
IPR051854 | 51,854 | Rho-type GTPase-activating protein | Rho-type_GAP | Family | 5,123 | true | false | This family of proteins includes GTPase-activating proteins (GAPs) primarily for the p21-rac subfamily of Rho GTPases. Members of this family are involved in the negative regulation of Rac by accelerating the hydrolysis of GTP to GDP, thereby inactivating the GTPase. This action is crucial for controlling various cellu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46075"
] | [
"Rho-type_GAP"
] | [
5123
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-9013148",
"R-DDI-9013149",
"R-HSA-9013148",
"R-HSA-9013149",
"R-MMU-9013148",
"R-MMU-9013149",
"R-RNO-9013149",
"R-SPO-9013148",
"R-SPO-9013405",
"R-SPO-9013424",
"R-SPO-9035034"
] | [
"REACTOME:R-DDI-9013148",
"REACTOME:R-DDI-9013149",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-MMU-9013148",
"REACTOME:R-MMU-9013149",
"REACTOME:R-RNO-9013149",
"REACTOME:R-SPO-9013148",
"REACTOME:R-SPO-9013405",
"REACTOME:R-SPO-9013424",
"REACTOME:R-SPO-9035034"
] | 11 | [
"1pbw",
"1xa6",
"2osa",
"3cxl",
"6d81",
"6d82",
"6d85",
"6d86",
"6d87",
"6mrp"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5123
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
3,
2,
44,
18,
23,
1
] | 7 | true | Family | Rho-type GTPase-activating protein | Rho-type GTPase-activating protein | Rho-type_GAP | 1 |
IPR051855 | 51,855 | Eukaryotic initiation factor 2B subunit beta | eIF2B_beta_subunit | Family | 4,993 | true | false | This family of proteins functions as components of the translation initiation factor 2B (eIF2B) complex, which is responsible for the exchange of GDP for GTP on the eIF2 gamma subunit. This activity is crucial for the initiation of protein synthesis as it allows the formation of the eIF2-GTP-methionyl-initiator methion... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45859"
] | [
"eIF2B_beta_subunit"
] | [
4993
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72731",
"R-DDI-72731",
"R-HSA-72731",
"R-MMU-72731",
"R-RNO-72731",
"R-SCE-72731",
"R-SPO-72731"
] | [
"REACTOME:R-BTA-72731",
"REACTOME:R-DDI-72731",
"REACTOME:R-HSA-72731",
"REACTOME:R-MMU-72731",
"REACTOME:R-RNO-72731",
"REACTOME:R-SCE-72731",
"REACTOME:R-SPO-72731"
] | 7 | [
"4zem",
"5b04",
"5dbo",
"6caj",
"6ezo",
"6i3m",
"6i7t",
"6jly",
"6jlz",
"6k71",
"6k72",
"6o81",
"6o85",
"6o9z",
"6qg0",
"6qg1",
"6qg2",
"6qg3",
"6qg5",
"6qg6",
"7d43",
"7d44",
"7d45",
"7d46",
"7f64",
"7f66",
"7f67",
"7kmf",
"7l70",
"7l7g",
"7rlo",
"7trj"... | 35 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
14,
38,
4933,
8
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
1,
6,
4,
1,
7,
8,
1,
1,
21
] | 12 | true | Family | Eukaryotic initiation factor 2B subunit beta | Eukaryotic initiation factor 2B subunit beta | eIF2B_beta_subunit | 3 |
IPR051856 | 51,856 | Cell Surface Receptor and E3 Ligase Protein | CSR-E3_Ligase_Protein | Family | 4,861 | true | false | This family of proteins includes cell surface receptors and enzymes with roles in cellular fusion, differentiation, and immune system homeostasis. Members are involved in processes such as osteoclast bone resorption, osteoclastogenesis, and sperm-egg fusion during fertilization. Some proteins in this family function as... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21041"
] | [
"CSR-E3_Ligase_Protein"
] | [
4861
] | 1 | [
"REACTOME"
] | [
"R-HSA-8874211"
] | [
"REACTOME:R-HSA-8874211"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Nocardioides malaquae"
] | [
4860,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
52,
7,
9,
8,
10
] | 6 | true | Family | Cell Surface Receptor and E3 Ligase Protein | Cell Surface Receptor and E3 Ligase Protein | CSR-E3_Ligase_Protein | 1 |
IPR051857 | 51,857 | Asparagine synthetase domain-containing protein | Asn_synthetase_domain | Family | 4,918 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of the amino acid asparagine. Members of this family contain a domain that is responsible for the catalysis of the ATP-dependent conversion of aspartic acid to asparagine, a reaction that is critical for nitrogen metabolism and amino acid ho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45937"
] | [
"Asn_synthetase_domain"
] | [
4918
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota"
] | [
15,
4903
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
1,
4,
3,
1,
4,
3,
1,
1,
10
] | 12 | true | Family | Asparagine synthetase domain-containing protein | Asparagine synthetase domain-containing protein | Asn_synthetase_domain | 3 |
IPR051858 | 51,858 | WD repeat-containing GAD-1 | WD_repeat_GAD-1 | Family | 4,818 | true | false | The WD repeat GAD-1 family is characterized by proteins that contain WD repeats, which are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his (GH) and tryptophan-aspartic acid (WD) dipeptides. Members of the family are involved in a variety of cellular processes through their rol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16017"
] | [
"WD_repeat_GAD-1"
] | [
4818
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72163",
"R-DME-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163",
"R-SPO-72163",
"R-XTR-72163"
] | [
"REACTOME:R-CEL-72163",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163",
"REACTOME:R-SPO-72163",
"REACTOME:R-XTR-72163"
] | 7 | [
"6zym",
"7a5p",
"8i0w"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4818
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
5,
1,
2,
1,
3,
2,
1,
3,
3,
1,
7
] | 11 | true | Family | WD repeat-containing GAD-1 | WD repeat-containing GAD-1 | WD_repeat_GAD-1 | 8 |
IPR051859 | 51,859 | DDB1- and CUL4-associated factor | DCAF | Family | 4,851 | true | false | This family of proteins appears to be involved in ubiquitin-mediated proteolysis, acting as potential substrate receptors for the CUL4-DDB1 E3 ubiquitin-protein ligase complex. Some members are implicated in the regulation of lifespan and neuronal degeneration in response to metal stress. They may also interact with th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19847"
] | [
"DCAF"
] | [
4851
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8951664",
"R-HSA-8951664",
"R-MMU-8951664",
"R-RNO-8951664"
] | [
"REACTOME:R-CEL-8951664",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-8951664",
"REACTOME:R-RNO-8951664"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4851
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
4,
2,
1,
9,
5,
1,
9,
4,
32
] | 10 | true | Family | DDB1- and CUL4-associated factor | DDB1- and CUL4-associated factor | DCAF | 6 |
IPR051860 | 51,860 | Plasmodium Circumsporozoite Invasion Protein | Plasmodium_CSP_Invasion | Family | 7,436 | true | false | This family of proteins is involved in the life cycle of the malaria parasite, Plasmodium. Members of this family play a crucial role in the parasite's ability to infect both mosquito vectors and vertebrate hosts. In the mosquito, these proteins are necessary for the development of sporozoites within the oocyst, their ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44826"
] | [
"Plasmodium_CSP_Invasion"
] | [
7436
] | 1 | [] | [] | [] | 0 | [
"6mb3",
"6mhg",
"7v05",
"8dyw",
"8dyx",
"8dyy",
"8dz3",
"8dz4",
"8dz5",
"8eh5",
"8ek1",
"8eka"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcinales",
"Viruses",
"metagenomes"
] | [
425,
6976,
2,
10,
23
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Rattus norvegicus"
] | [
7,
3,
2
] | 3 | true | Family | Plasmodium Circumsporozoite Invasion Protein | Plasmodium Circumsporozoite Invasion Protein | Plasmodium_CSP_Invasion | 6 |
IPR051861 | 51,861 | NET actin-binding domain-containing protein | NET_actin-binding_domain | Family | 5,421 | true | false | This family of proteins is characterized by a plant-specific role in actin binding and association with various cellular structures. Members of this family are involved in forming membrane-cytoskeletal adapter complexes that may bridge the endoplasmic reticulum and the plasma membrane or associate with F-actin at the t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32258"
] | [
"NET_actin-binding_domain"
] | [
5421
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus phage F16Ba",
"Bacteria",
"Eukaryota"
] | [
1,
27,
5393
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
36,
35,
96
] | 3 | true | Family | NET actin-binding domain-containing protein | NET actin-binding domain-containing protein | NET_actin-binding_domain | 7 |
IPR051862 | 51,862 | Glycosyltransferase-like domain-containing protein 1 | GT-like_domain_containing_1 | Family | 2,781 | true | false | This family of proteins is characterized by a glycosyltransferase-like domain. Members of this family are involved in the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The activity of these enzymes is critical for the biosynthesis of complex carbohyd... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13615"
] | [
"GT-like_domain_containing_1"
] | [
2781
] | 1 | [
"EC"
] | [
"2.4.1.110"
] | [
"EC:2.4.1.110"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
621,
2101,
58,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
5,
6,
13
] | 5 | true | Family | Glycosyltransferase-like domain-containing protein 1 | Glycosyltransferase-like domain-containing protein 1 | GT-like_domain_containing_1 | 4 |
IPR051863 | 51,863 | Heavy metal-associated isoprenylated plant | HIPP | Family | 5,431 | true | false | The HIPP family comprises proteins that are likely involved in binding heavy metals. Members of this family are characterized by the presence of a heavy metal-associated domain, which suggests a role in the homeostasis or detoxification of heavy metals within the plant. These proteins are isoprenylated, which may influ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45811"
] | [
"HIPP"
] | [
5431
] | 1 | [] | [] | [] | 0 | [
"9rsv"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spermatophyta"
] | [
5431
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
57,
34,
26
] | 3 | true | Family | Heavy metal-associated isoprenylated plant | Heavy metal-associated isoprenylated plant | HIPP | 3 |
IPR051864 | 51,864 | NADPH Oxidase Activator | NCF2_NOXA1 | Family | 4,186 | true | false | The NCF2/NOXA1 family comprises proteins that play a crucial role in the activation of NADPH oxidases, which are enzymes responsible for the production of superoxide and other reactive oxygen species (ROS). These ROS are involved in various biological processes, including host defense mechanisms, hormone biosynthesis, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15175"
] | [
"NCF2_NOXA1"
] | [
4186
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1222556",
"R-HSA-1236973",
"R-HSA-3299685",
"R-HSA-4420097",
"R-HSA-5668599",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013423",
"R-HSA-9673324",
"R-MMU-1222556",
"R-MMU-1236973",
"R-MMU-3299685",
"R-MMU-4420097",
"R-MMU-5668599",
"R-MMU-9013149",
"R-MMU-9013404",
"R-MMU-90134... | [
"REACTOME:R-HSA-1222556",
"REACTOME:R-HSA-1236973",
"REACTOME:R-HSA-3299685",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-5668599",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013423",
"REACTOME:R-HSA-9673324",
"REACTOME:R-MMU-1222556",
"REACTOME:R-MMU-1236973",
"REACTOM... | 25 | [
"1e96",
"1hh8",
"1k4u",
"1oey",
"1wm5",
"2dmo",
"7cfz",
"8wej"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4186
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
8,
4,
1,
9,
1
] | 6 | true | Family | NADPH Oxidase Activator | NADPH Oxidase Activator | NCF2_NOXA1 | 1 |
IPR051865 | 51,865 | WD repeat-containing CDT2 adapter protein | WD-repeat_CDT2_adapter | Family | 4,325 | true | false | This family of proteins serves as substrate-specific adapters for DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes, which are crucial for cell cycle control, DNA damage response, and translesion DNA synthesis. Members of this family mediate the polyubiquitination and subsequent degradation of various substra... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22852"
] | [
"WD-repeat_CDT2_adapter"
] | [
4325
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-110314",
"R-DME-8951664",
"R-DRE-8951664",
"R-GGA-110314",
"R-GGA-8951664",
"R-HSA-110314",
"R-HSA-8951664",
"R-MMU-110314",
"R-MMU-8951664",
"R-SPO-110314",
"R-SPO-8951664",
"R-XTR-110314",
"R-XTR-8951664"
] | [
"REACTOME:R-DME-110314",
"REACTOME:R-DME-8951664",
"REACTOME:R-DRE-8951664",
"REACTOME:R-GGA-110314",
"REACTOME:R-GGA-8951664",
"REACTOME:R-HSA-110314",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-110314",
"REACTOME:R-MMU-8951664",
"REACTOME:R-SPO-110314",
"REACTOME:R-SPO-8951664",
"REACTOME:R-X... | 13 | [
"9c5t",
"9c5u",
"9c5v"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4325
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
6,
1,
3,
1,
3,
3,
1,
5,
3,
1,
17
] | 11 | true | Family | WD repeat-containing CDT2 adapter protein | WD repeat-containing CDT2 adapter protein | WD-repeat_CDT2_adapter | 2 |
IPR051866 | 51,866 | Intracellular Signaling and Trafficking Protein | Intracell_Sig-Traffick_Protein | Family | 4,187 | true | false | This family of proteins is involved in intracellular signaling and trafficking processes. Members of this family play roles in the localization and trafficking of proteins from the plasma membrane to various intracellular compartments, such as recycling endosomes and the trans-Golgi network. Some proteins within this f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15508"
] | [
"Intracell_Sig-Traffick_Protein"
] | [
4187
] | 1 | [] | [] | [] | 0 | [
"4a5x",
"6ecm",
"6mbi"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4187
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
2,
22,
11,
19
] | 6 | true | Family | Intracellular Signaling and Trafficking Protein | Intracellular Signaling and Trafficking Protein | Intracell_Sig-Traffick_Protein | 6 |
IPR051867 | 51,867 | Angiogenesis Inhibitor and Adhesion GPCR | Angio_Inhib/Adhesion_GPCR | Family | 4,434 | true | false | This family of proteins includes members that are involved in cell adhesion, cell-cell interactions, and angiogenesis inhibition. Some proteins in this family act as angiogenesis inhibitors, potentially influencing various angiogenesis processes. They may also function as orphan G-protein coupled receptors that activat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10239"
] | [
"Angio_Inhib/Adhesion_GPCR"
] | [
4434
] | 1 | [] | [] | [] | 0 | [
"8oek",
"9c6t"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4434
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
51,
15,
13,
13
] | 4 | true | Family | Angiogenesis Inhibitor and Adhesion GPCR | Angiogenesis Inhibitor and Adhesion GPCR | Angio_Inhib/Adhesion_GPCR | 7 |
IPR051868 | 51,868 | Zinc finger protein 346 and matrin-type protein 4 | ZN346_ZMAT4 | Family | 3,857 | true | false | The Zinc finger protein 346 family is characterized by the presence of zinc-finger domains essential for binding to double-stranded RNA (dsRNA) and for nuclear localization. Members of this family show a preference for binding to dsRNA, although they can also interact with RNA-DNA hybrids. Some members have been report... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46144"
] | [
"ZN346_ZMAT4"
] | [
3857
] | 1 | [] | [] | [] | 0 | [
"1zu1",
"2mkd",
"2mkn"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3857
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
13,
8,
11,
4,
7,
5
] | 7 | true | Family | Zinc finger protein 346 and matrin-type protein 4 | Zinc finger protein 346 and matrin-type protein 4 | ZN346_ZMAT4 | 8 |
IPR051869 | 51,869 | StAR-related Lipid Transfer (STARD3) | STARD3 | Family | 3,853 | true | false | The STARD3 family includes sterol-binding proteins that facilitate cholesterol transport from the endoplasmic reticulum to endosomes. The transport is initiated by phosphorylation of an FFAT motif, which promotes membrane tethering. Family members act as lipid transfer proteins, redistributing sterol to endosomes at th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46121"
] | [
"STARD3"
] | [
3853
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-196108",
"R-HSA-196108",
"R-MMU-196108"
] | [
"REACTOME:R-DRE-196108",
"REACTOME:R-HSA-196108",
"REACTOME:R-MMU-196108"
] | 3 | [
"1em2",
"5i9j",
"7ztq",
"7ztr",
"7ztu",
"7zvq",
"7zvr",
"8aaq"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3853
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2,
19,
7,
7
] | 6 | true | Family | StAR-related Lipid Transfer (STARD3) | StAR-related Lipid Transfer (STARD3) | STARD3 | 4 |
IPR051870 | 51,870 | Elongin-A domain-containing protein | Elongin-A_domain | Family | 3,933 | true | false | This family of proteins functions as general transcription elongation factors known as elongin or SIII. They enhance the RNA polymerase II transcription elongation past sites that would otherwise arrest transcription. Members of this family are transcriptionally active, with some showing increased activity upon binding... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15141"
] | [
"Elongin-A_domain"
] | [
3933
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-112382",
"R-CEL-674695",
"R-CEL-6796648",
"R-CEL-75955",
"R-DME-112382",
"R-DME-674695",
"R-DME-6796648",
"R-DME-75955",
"R-HSA-112382",
"R-HSA-167152",
"R-HSA-167200",
"R-HSA-167238",
"R-HSA-167243",
"R-HSA-167246",
"R-HSA-167287",
"R-HSA-167290",
"R-HSA-674695",
"R-HSA-679... | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6796648",
"REACTOME:R-CEL-75955",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6796648",
"REACTOME:R-DME-75955",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-167152",
"REACTOME:R-HSA-167200",
"REACTOME:R-HSA-167... | 28 | [
"4hfx",
"6zuz",
"8oev",
"8oew",
"8of0"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3933
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
8,
2,
5,
2,
8,
1,
1
] | 8 | true | Family | Elongin-A domain-containing protein | Elongin-A domain-containing protein | Elongin-A_domain | 8 |
IPR051872 | 51,872 | Cytochrome b5/Flavoprotein Reductase | Cytochrome_b5/Flavoprotein_Rdt | Family | 4,730 | true | false | This family of proteins includes various members that are involved in electron transfer processes, particularly associated with the cytochrome b5 and flavoprotein pyridine nucleotide cytochrome reductase systems. They play roles in metabolic pathways such as the endoplasmic reticulum stress response pathway and protect... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46237"
] | [
"Cytochrome_b5/Flavoprotein_Rdt"
] | [
4730
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1237044",
"R-DRE-1237044",
"R-HSA-1237044",
"R-MMU-1237044",
"R-RNO-1237044",
"R-XTR-1237044"
] | [
"REACTOME:R-BTA-1237044",
"REACTOME:R-DRE-1237044",
"REACTOME:R-HSA-1237044",
"REACTOME:R-MMU-1237044",
"REACTOME:R-RNO-1237044",
"REACTOME:R-XTR-1237044"
] | 6 | [
"3ks0",
"3lf5",
"8tgb"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"freshwater metagenome"
] | [
4729,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
4,
8,
3,
3,
1,
1,
2,
8,
1,
2,
7
] | 12 | true | Family | Cytochrome b5/Flavoprotein Reductase | Cytochrome b5/Flavoprotein Reductase | Cytochrome_b5/Flavoprotein_Rdt | 3 |
IPR051873 | 51,873 | Cell wall assembly regulator KNR4/SMI1 | KNR4/SMI1_regulator | Family | 3,376 | true | false | This family of proteins is involved in the regulation of cell wall assembly, particularly in the synthesis of 1,3-beta-glucan, which is a key component of the cell wall in various fungi. Members of this family may play a role in the transcriptional regulation of enzymes responsible for glucan and chitin synthesis, whic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47432"
] | [
"KNR4/SMI1_regulator"
] | [
3376
] | 1 | [] | [] | [] | 0 | [
"5j1b",
"6qbm",
"6qbn",
"6qbo",
"6qbp",
"6qbq",
"6qbr",
"8aj2"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"marine sediment metagenome"
] | [
1701,
1671,
3,
1
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Cell wall assembly regulator KNR4/SMI1 | Cell wall assembly regulator KNR4/SMI1 | KNR4/SMI1_regulator | 5 |
IPR051874 | 51,874 | Immunoglobulin-like domain-containing protein LISCH7 | Ig-like_domain-LISCH7 | Family | 3,554 | true | false | This family of proteins is involved in maintaining epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions, which is crucial for normal hearing and the survival of auditory neurosensory hair cells. Members of this family may also be implicated in lipid homeostasis, ins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15923"
] | [
"Ig-like_domain-LISCH7"
] | [
3554
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8964038",
"R-HSA-8964046"
] | [
"REACTOME:R-HSA-8964038",
"REACTOME:R-HSA-8964046"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
3554
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
16,
10,
24
] | 4 | true | Family | Immunoglobulin-like domain-containing protein LISCH7 | Immunoglobulin-like domain-containing protein LISCH7 | Ig-like_domain-LISCH7 | 2 |
IPR051876 | 51,876 | Outer dynein arm-docking/Coiled-coil domain-containing protein | ODA-DC/CCD | Family | 3,656 | true | false | This family of proteins includes components of the outer dynein arm-docking complex (ODA-DC), which are crucial for the binding of outer dynein arms (ODA) onto doublet microtubules. Members are involved in the assembly of ODAs and their axonemal docking complex, facilitating the proper function of ciliary microtubules.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21694"
] | [
"ODA-DC/CCD"
] | [
3656
] | 1 | [] | [] | [] | 0 | [
"6u42",
"7kzm",
"7kzo",
"7moq",
"7rro",
"8glv",
"8j07",
"9cpb",
"9cpc",
"9e5c",
"9e78",
"9fqr"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3656
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
5,
8,
9
] | 5 | true | Family | Outer dynein arm-docking/Coiled-coil domain-containing protein | Outer dynein arm-docking/Coiled-coil domain-containing protein | ODA-DC/CCD | 2 |
IPR051877 | 51,877 | Centriole and Basal Body Structural Protein | Centriole_BasalBody_StrucProt | Family | 3,670 | true | false | This family of proteins is involved in the structural organization and biogenesis of microtubule-associated complexes. Members of this family play a crucial role in cytoskeletal organization, particularly in the formation and cohesion of centrioles and basal bodies, which are key components of the centrosome and cilia.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR20544"
] | [
"Centriole_BasalBody_StrucProt"
] | [
3670
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [
"5fcm",
"7bji",
"9qzc",
"9qzf"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Marseillevirus sp."
] | [
7,
34,
3628,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
3,
7,
8,
16
] | 5 | true | Family | Centriole and Basal Body Structural Protein | Centriole and Basal Body Structural Protein | Centriole_BasalBody_StrucProt | 8 |
IPR051878 | 51,878 | ZNRF ubiquitin-protein ligase | ZNRF_ubiq-protein_ligase | Family | 3,843 | true | false | The ZNRF ubiquitin-protein ligase family is characterized by its members' E3 ubiquitin ligase activity, which is crucial for various biological processes including neuronal transmission, plasticity, cell differentiation, and inflammation regulation. Members of this family ubiquitinate specific substrates such as the Na... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46661"
] | [
"ZNRF_ubiq-protein_ligase"
] | [
3843
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-983168",
"R-DRE-983168",
"R-HSA-983168",
"R-MMU-983168",
"R-XTR-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-983168",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-XTR-983168"
] | 7 | [
"5ywr"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3843
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
5,
2,
8,
11,
9
] | 6 | true | Family | ZNRF ubiquitin-protein ligase | ZNRF ubiquitin-protein ligase | ZNRF_ubiq-protein_ligase | 5 |
IPR051879 | 51,879 | C2H2-type Zinc Finger Maturation Protein | C2H2-ZF_Maturation_Protein | Family | 3,193 | true | false | This family of proteins is involved in the maturation of pre-60S ribosomal particles, specifically by promoting the nuclear export of the 60S ribosome. Members of this family are characterized by the presence of a C2H2-type zinc-finger domain, which is typically associated with DNA-binding activity. However, some famil... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46095"
] | [
"C2H2-ZF_Maturation_Protein"
] | [
3193
] | 1 | [] | [] | [] | 0 | [
"1zr9",
"3jct",
"6ft6",
"6lss",
"6lu8",
"6m62",
"6n8j",
"6n8k",
"6n8l",
"6ylg",
"6ylh",
"6yly",
"7ug6",
"7uoo",
"7uqb",
"7uqz",
"7v08",
"7z34",
"8fl2",
"8fl3",
"8fl4",
"8fl6",
"8fl7",
"8fl9",
"8fla",
"8flb",
"8flc",
"8fld",
"8fle",
"8flf",
"8hfr",
"8idt"... | 52 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3193
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
1,
2,
2,
1,
3,
1,
1
] | 9 | true | Family | C2H2-type Zinc Finger Maturation Protein | C2H2-type Zinc Finger Maturation Protein | C2H2-ZF_Maturation_Protein | 5 |
IPR051881 | 51,881 | Copper transport ATOX1-like | Copper_transport_ATOX1-like | Family | 3,042 | true | false | This family of proteins is involved in the cellular transport of copper ions. Members of this family bind copper ions in the cytosol and deliver them to copper ATPase transport proteins, which are responsible for the distribution of copper to various cellular compartments and copper-dependent enzymes. The proteins cont... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46365"
] | [
"Copper_transport_ATOX1-like"
] | [
3042
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-6803544",
"R-HSA-3299685",
"R-HSA-6803544",
"R-MMU-6803544",
"R-RNO-6803544"
] | [
"REACTOME:R-CFA-6803544",
"REACTOME:R-HSA-3299685",
"REACTOME:R-HSA-6803544",
"REACTOME:R-MMU-6803544",
"REACTOME:R-RNO-6803544"
] | 5 | [
"1cc7",
"1cc8",
"1fd8",
"1fe0",
"1fe4",
"1fee",
"1fes",
"1tl4",
"1tl5",
"2crl",
"2ggp",
"2k1r",
"2lq9",
"3cjk",
"3iwl",
"3iwx",
"3k7r",
"4qot",
"4ydx",
"4yea",
"5f0w",
"5t7l",
"5vde",
"5vdf",
"7dc1",
"7zc3"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
3038,
4
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
2,
5,
1,
1,
4,
1,
1
] | 9 | true | Family | Copper transport ATOX1-like | Copper transport ATOX1-like | Copper_transport_ATOX1-like | 1 |
IPR051883 | 51,883 | Aquaporin-11/12 water channel | AQP11/12_channel | Family | 2,854 | true | false | This family of proteins facilitates the transport of water and small neutral solutes across cell membranes, ensuring intracellular homeostasis in various organs such as the liver, kidney, and brain. Members of this family are involved in maintaining endoplasmic reticulum homeostasis, particularly under stress condition... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21191"
] | [
"AQP11/12_channel"
] | [
2854
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-432047",
"R-HSA-432047",
"R-MMU-432047",
"R-RNO-432047"
] | [
"REACTOME:R-CEL-432047",
"REACTOME:R-HSA-432047",
"REACTOME:R-MMU-432047",
"REACTOME:R-RNO-432047"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2854
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
2,
5,
5,
7
] | 6 | true | Family | Aquaporin-11/12 water channel | Aquaporin-11/12 water channel | AQP11/12_channel | 8 |
IPR051884 | 51,884 | Bis(5'-adenosyl)-triphosphatase activity regulators | Bis(5'-adenosyl)-TPase_reg | Family | 2,952 | true | false | This family of proteins is involved in the hydrolysis of dinucleoside polyphosphates, particularly those containing a purine base and at least three phosphate groups. The primary activity observed in these proteins is the cleavage of bis(5'-adenosyl)-triphosphates to produce AMP and ADP. This enzymatic function plays a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46243"
] | [
"Bis(5'-adenosyl)-TPase_reg"
] | [
2952
] | 1 | [
"EC"
] | [
"3.6.1.29"
] | [
"EC:3.6.1.29"
] | 1 | [
"5cs2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Parvarchaeota",
"Eukaryota",
"Nevevirus",
"bioreactor metagenome"
] | [
23,
3,
2921,
4,
1
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
10,
1,
1,
5
] | 6 | true | Family | Bis(5'-adenosyl)-triphosphatase activity regulators | Bis(5'-adenosyl)-triphosphatase activity regulators | Bis(5'-adenosyl)-TPase_reg | 7 |
IPR051885 | 51,885 | Coiled-coil domain-containing protein involved in ciliogenesis | CC_CF | Family | 2,820 | true | true | This family of proteins includes components associated with centriolar satellites, which are crucial for primary cilium formation. The primary cilium is a microtubule-based organelle that extends from the surface of many vertebrate cells and is involved in signal transduction. The proteins in this family contain coiled... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15654"
] | [
"CC_domain-Cilium_Assoc"
] | [
2820
] | 1 | [] | [] | [] | 0 | [
"8glv",
"8j07",
"8tek",
"8th8",
"8tid",
"9e5c",
"9fqr"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2820
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
15,
2,
3,
5
] | 5 | true | Family | Coiled-coil domain-containing protein involved in ciliogenesis | Coiled-coil domain-containing protein involved in ciliogenesis | CC_CF | 1 |
IPR051886 | 51,886 | Seed Development and Stress Response Regulator | Seed_Dev/Stress_Resp_Reg | Family | 3,591 | true | false | This family of proteins is involved in various aspects of plant development and stress responses. Members are known to regulate seed dormancy, germination, and maturation processes, often through interactions with abscisic acid signaling pathways. Some proteins in this family determine the temperature window for seed g... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46354"
] | [
"Seed_Dev/Stress_Resp_Reg"
] | [
3591
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
3591
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
75,
11,
13
] | 3 | true | Family | Seed Development and Stress Response Regulator | Seed Development and Stress Response Regulator | Seed_Dev/Stress_Resp_Reg | 9 |
IPR051887 | 51,887 | Glycosyl Hydrolase 18 Domain-Containing Protein | GH18_Domain-Containing | Family | 1,588 | true | false | This family of proteins includes enzymes that are primarily involved in the degradation of asparagine-linked glycoproteins. Members of this family exhibit glycosyl hydrolase activity, specifically targeting the hydrolysis of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core. This enzymatic action typ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46290"
] | [
"GH18_Domain-Containing"
] | [
1588
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.2.1.-",
"PWY-1921",
"PWY-5821",
"PWY-5976",
"PWY-6527",
"PWY-6717",
"PWY-6735",
"PWY-6737",
"PWY-6749",
"PWY-6784",
"PWY-6821",
"PWY-6848",
"PWY-6855",
"PWY-6906",
"PWY-6972",
"PWY-7056",
"PWY-7057",
"PWY-7074",
"PWY-7091",
"PWY-7133",
"PWY-7134",
"PWY-7256",
"PWY-7445... | [
"EC:3.2.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5821",
"METACYC:PWY-5976",
"METACYC:PWY-6527",
"METACYC:PWY-6717",
"METACYC:PWY-6735",
"METACYC:PWY-6737",
"METACYC:PWY-6749",
"METACYC:PWY-6784",
"METACYC:PWY-6821",
"METACYC:PWY-6848",
"METACYC:PWY-6855",
"METACYC:PWY-6906",
"METACYC:PWY-6... | 31 | [
"3cz8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"ecological metagenomes"
] | [
197,
1328,
46,
17
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
1,
3
] | 4 | true | Family | Glycosyl Hydrolase 18 Domain-Containing Protein | Glycosyl Hydrolase 18 Domain-Containing Protein | GH18_Domain-Containing | 6 |
IPR051888 | 51,888 | UPF0148 domain-containing protein | UPF0148_domain | Family | 2,151 | true | false | This family of proteins is associated with a variety of cellular functions, including potential roles in mitosis and centromere association. Members of this family may have antigenic properties and could induce the production of anti-centromere antibodies. The precise functions of these proteins may vary among differen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16537"
] | [
"UPF0148_domain"
] | [
2151
] | 1 | [] | [] | [] | 0 | [
"6hcz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"ecological metagenomes"
] | [
470,
1674,
7
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
6,
6,
2,
1
] | 6 | true | Family | UPF0148 domain-containing protein | UPF0148 domain-containing protein | UPF0148_domain | 8 |
IPR051889 | 51,889 | Centrosomal protein 41 | CEP41 | Family | 1,910 | true | false | This family of proteins is involved in the process of ciliogenesis, specifically in the post-translational modification of tubulin through glutamylation. Members of this family are implicated in the intracellular transport of tubulin polyglutamylases, such as TTLL6, from the basal body to the cilium. This modification ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44390"
] | [
"CEP41"
] | [
1910
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2565942",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5620912",
"R-BTA-8854518",
"R-GGA-2565942",
"R-GGA-380259",
"R-GGA-380270",
"R-GGA-380284",
"R-GGA-380320",
"R-GGA-5620912",
"R-GGA-8854518",
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-... | [
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BTA-5620912",
"REACTOME:R-BTA-8854518",
"REACTOME:R-GGA-2565942",
"REACTOME:R-GGA-380259",
"REACTOME:R-GGA-380270",
"REACTOME:R-GGA-380284",
"REACTOME:R-GGA... | 41 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1910
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
16,
8,
2
] | 5 | true | Family | Centrosomal protein 41 | Centrosomal protein 41 | CEP41 | 6 |
IPR051892 | 51,892 | LBX Family Transcription Factors | LBX_TF | Family | 1,858 | true | false | The LBX family of transcription factors is involved in various developmental processes. Members of the family are essential for the development of GABAergic interneurons in the spinal cord, migration and development of hypaxial muscle precursor cells for limb muscles, diaphragm, and hypoglossal cord. They regulate hypa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24336"
] | [
"LBX_TF"
] | [
1858
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1858
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
17,
4,
2,
4
] | 5 | true | Family | LBX Family Transcription Factors | LBX Family Transcription Factors | LBX_TF | 4 |
IPR051893 | 51,893 | Hydroxycarboxylic Acid Receptors | HCARs | Family | 1,765 | true | false | The Hydroxycarboxylic Acid Receptor family includes G-protein coupled receptors that mediate various physiological responses to hydroxycarboxylic acids, eicosanoids, and other ligands. Members of this family act as receptors for compounds such as L-lactate, nicotinic acid, (D)-beta-hydroxybutyrate, and 12-(S)-hydroxy-5... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46048"
] | [
"HCARs"
] | [
1765
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3296197",
"R-HSA-373076",
"R-HSA-391903",
"R-HSA-418594",
"R-HSA-444209",
"R-MMU-3296197",
"R-MMU-373076",
"R-MMU-418594",
"R-MMU-444209",
"R-RNO-3296197",
"R-RNO-373076",
"R-RNO-418594"
] | [
"REACTOME:R-HSA-3296197",
"REACTOME:R-HSA-373076",
"REACTOME:R-HSA-391903",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-444209",
"REACTOME:R-MMU-3296197",
"REACTOME:R-MMU-373076",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-444209",
"REACTOME:R-RNO-3296197",
"REACTOME:R-RNO-373076",
"REACTOME:R-RNO-... | 12 | [
"7xk2",
"7zl9",
"7zly",
"8h2g",
"8i7v",
"8i7w",
"8ihb",
"8ihf",
"8ihh",
"8ihi",
"8ihj",
"8ihk",
"8ij3",
"8ija",
"8ijb",
"8ijd",
"8iy9",
"8iyh",
"8iyw",
"8j6i",
"8j6j",
"8j6l",
"8j6p",
"8j6q",
"8j6r",
"8jef",
"8jei",
"8jer",
"8jhn",
"8jhy",
"8jii",
"8jil"... | 53 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1765
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
10,
7,
8
] | 4 | true | Family | Hydroxycarboxylic Acid Receptors | Hydroxycarboxylic Acid Receptors | HCARs | 5 |
IPR051895 | 51,895 | Orthopedia Homeobox | OTP_Homeobox | Family | 1,607 | true | false | This family of proteins is primarily involved in the development and differentiation of neuroendocrine cells within the hypothalamus, as well as in the patterning of larval skeletal structures. Members of this family play crucial roles in the specification of various neuron types, including dopaminergic neurons in spec... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46770"
] | [
"OTP_Homeobox"
] | [
1607
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1607
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
7,
1,
1,
4
] | 5 | true | Family | Orthopedia Homeobox | Orthopedia Homeobox | OTP_Homeobox | 3 |
IPR051896 | 51,896 | T cell receptor alpha variable region | TCR_alpha_variable | Family | 1,517 | true | false | This family of proteins includes variable regions of the alpha chain of T cell receptors (TRs), which are crucial for antigen recognition. These proteins are part of the alpha-beta TRs, which are antigen-specific and essential for the immune response. They are present on T lymphocytes and recognize peptide-major histoc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19339"
] | [
"TCR_alpha_variable"
] | [
1517
] | 1 | [] | [] | [] | 0 | [
"1h5b",
"1ymm",
"1ypz",
"2ial",
"2iam",
"2ian",
"2wbj",
"3axl",
"3mbe",
"3qib",
"3qiu",
"3qiw",
"3qjf",
"3qjh",
"3rug",
"4c56",
"4e41",
"4e42",
"4jry",
"4mji",
"4mnq",
"4p2o",
"4p2q",
"4p2r",
"4udt",
"4udu",
"5fk9",
"5fka",
"5men",
"6bga",
"6mra",
"6mss"... | 39 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1517
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
49,
70
] | 3 | true | Family | T cell receptor alpha variable region | T cell receptor alpha variable region | TCR_alpha_variable | 8 |
IPR051897 | 51,897 | Polygalacturonase-associated BURP domain-containing protein | PG-associated_BURP | Family | 1,936 | true | false | This family of proteins includes non-catalytic subunits of polygalacturonase as well as proteins containing a BURP domain at the C-terminus. Members of this family are involved in the regulation of plant cell size and growth, with some acting as chaperones for other proteins through the secretory pathway. The BURP doma... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31458"
] | [
"PG-associated_BURP"
] | [
1936
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
1930,
6
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
5,
6
] | 3 | true | Family | Polygalacturonase-associated BURP domain-containing protein | Polygalacturonase-associated BURP domain-containing protein | PG-associated_BURP | 2 |
IPR051898 | 51,898 | Ribosome Assembly Protein 3 | Ribosome_Assembly_3 | Family | 1,232 | true | false | This family of proteins is involved in the assembly of the 60S ribosomal subunit, a critical component of the eukaryotic ribosome. Members of this family play a key role in the biogenesis of this subunit, ensuring that protein synthesis within the cell is carried out efficiently. The proper formation of the 60S ribosom... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28127"
] | [
"Ribosome_Assembly_3"
] | [
1232
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1232
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Ribosome Assembly Protein 3 | Ribosome Assembly Protein 3 | Ribosome_Assembly_3 | 1 |
IPR051899 | 51,899 | Fertilization and immune response mediator protein | Fert-Immune_med_protein | Family | 782 | true | false | This family of proteins includes members that are involved in various biological processes, including fertilization, signal transduction, and immune response. Some proteins in this family are known to play a role in the fertilization process by mediating the binding of sperm to the zona pellucida and facilitating the m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16529"
] | [
"Fert-Immune_med_protein"
] | [
782
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140875",
"R-HSA-163125",
"R-HSA-202733",
"R-HSA-6798695",
"R-MMU-140875",
"R-MMU-163125",
"R-MMU-202733",
"R-MMU-6798695",
"R-RNO-163125"
] | [
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-140875",
"REACTOME:R-MMU-163125",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-163125"
] | 9 | [
"7bpr",
"7bps"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mammalia"
] | [
782
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
12,
12
] | 3 | true | Family | Fertilization and immune response mediator protein | Fertilization and immune response mediator protein | Fert-Immune_med_protein | 1 |
IPR051900 | 51,900 | Serine palmitoyltransferase small subunit | SPT_small_subunit | Family | 742 | true | false | This family of proteins is involved in the biosynthesis of sphingolipids, which are essential components of cell membranes and play a role in signal transduction and cell recognition. Members of this family function as part of a multisubunit enzyme complex known as serine palmitoyltransferase (SPT). This complex cataly... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47084"
] | [
"SPT_small_subunit"
] | [
742
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1660661",
"R-DRE-1660661",
"R-HSA-1660661",
"R-MMU-1660661",
"R-RNO-1660661",
"R-XTR-1660661"
] | [
"REACTOME:R-BTA-1660661",
"REACTOME:R-DRE-1660661",
"REACTOME:R-HSA-1660661",
"REACTOME:R-MMU-1660661",
"REACTOME:R-RNO-1660661",
"REACTOME:R-XTR-1660661"
] | 6 | [
"6m4n",
"6m4o",
"7cqi",
"7cqk",
"7k0i",
"7k0j",
"7k0k",
"7k0l",
"7k0m",
"7k0n",
"7k0o",
"7k0p",
"7k0q",
"7yiu",
"7yiy",
"7yj1",
"7yj2"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
742
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
2
] | 4 | true | Family | Serine palmitoyltransferase small subunit | Serine palmitoyltransferase small subunit | SPT_small_subunit | 8 |
IPR051901 | 51,901 | Protease Inhibitor I33 | Protease_Inhibitor_I33 | Family | 368 | true | false | The protease inhibitor I33 family comprises proteins that function as aspartyl protease inhibitors. Members of this family are known to inhibit the activity of aspartic proteases such as pepsin. Aspartic proteases are a class of enzymes that play a crucial role in the digestive system by breaking down proteins into pep... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37969"
] | [
"Protease_Inhibitor_I33"
] | [
368
] | 1 | [] | [] | [] | 0 | [
"1f32",
"1f34"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
368
] | 1 | [
"Caenorhabditis elegans"
] | [
3
] | 1 | true | Family | Protease Inhibitor I33 | Protease Inhibitor I33 | Protease_Inhibitor_I33 | 6 |
IPR051902 | 51,902 | BPI fold-containing superfamily member | BPI_fold-superfamily_member | Family | 310 | true | false | This family of proteins includes lipid-binding components with a high affinity for certain phospholipids, such as dipalmitoylphosphatidylcholine. They are involved in the innate immune response, particularly in the upper airways, by reducing the surface tension of airway secretions and inhibiting biofilm formation by G... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47015"
] | [
"BPI_fold-superfamily_member"
] | [
310
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6803157",
"R-HSA-6803157",
"R-MMU-6803157",
"R-RNO-6803157"
] | [
"REACTOME:R-BTA-6803157",
"REACTOME:R-HSA-6803157",
"REACTOME:R-MMU-6803157",
"REACTOME:R-RNO-6803157"
] | 4 | [
"3zpm",
"4kgh",
"4kgo",
"5i7j",
"5i7k",
"5i7l",
"6baq"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Theria"
] | [
310
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
7
] | 3 | true | Family | BPI fold-containing superfamily member | BPI fold-containing superfamily member | BPI_fold-superfamily_member | 8 |
IPR051903 | 51,903 | Zein-alpha | Zein-alpha | Family | 188 | true | false | This family of proteins consists of seed storage proteins known as zeins, which are predominantly found in maize. Zeins accumulate in protein bodies within the endosperm of the maize seed and serve as a nutrient source during seed germination. They are characterized by their solubility in alcohol but insolubility in wa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48214"
] | [
"Zein-alpha"
] | [
188
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
188
] | 1 | [
"Zea mays"
] | [
144
] | 1 | true | Family | Zein-alpha | Zein-alpha | Zein-alpha | 6 |
IPR051905 | 51,905 | Schizosaccharomyces pombe Mam3/Map4 | S_pombe_Mam3/Map4 | Family | 158 | true | false | The Mam3/Map4 family proteins are primarily involved in cell agglutination during the process of conjugation in Schizosaccharomyces pombe. These proteins are implicated in colony formation and may play a role in flocculation, a process where cells adhere together to form clumps or flocs. The family includes specific pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31492"
] | [
"S_pombe_Mam3/Map4"
] | [
158
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
158
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
11
] | 1 | true | Family | Schizosaccharomyces pombe Mam3/Map4 | Schizosaccharomyces pombe Mam3/Map4 | S_pombe_Mam3/Map4 | 8 |
IPR051906 | 51,906 | Outer membrane protein TolC-like | TolC-like | Family | 58,677 | false | false | This protein family includes Outer membrane protein TolC from Escherichia coli, Protein CyaE from Bordetella pertussis and similar bacterial sequences. TolC is required for the function of several efflux systems involved in export of antibiotics and other toxic compounds from the cell [ , , , , ]. It plays a role in su... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30026"
] | [
""
] | [
58677
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9760173",
"R-HSA-9913143"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9760173",
"REACTOME:R-HSA-9913143"
] | 3 | [
"1ek9",
"1tqq",
"2vdd",
"2vde",
"2wmz",
"2xmn",
"5bun",
"5ng5",
"5nik",
"5nil",
"5o66",
"5v5s",
"6wxh",
"6wxi",
"7ng8",
"7ng9",
"8zal",
"8zar",
"9v52",
"9v53",
"9v55"
] | 21 | [
"PUB00001184",
"PUB00059764",
"PUB00068111",
"PUB00071889",
"PUB00159064",
"PUB00161072",
"PUB00161073",
"PUB00161074",
"PUB00161075"
] | [
"2184029",
"21245342",
"2905265",
"18955484",
"28504659",
"11274125",
"28355133",
"31201302",
"32850959"
] | [
"Protease secretion by Erwinia chrysanthemi: the specific secretion functions are analogous to those of Escherichia coli alpha-haemolysin.",
"Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.",
"Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-hae... | [
1990,
2011,
1988,
2009,
2017,
2001,
2017,
2019,
2020
] | 9 | [
"IPR003423"
] | [
"IPR010130",
"IPR028351"
] | 1 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
57560,
73,
1,
1043
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Outer membrane protein TolC-like | Outer membrane protein TolC-like | TolC-like | 4 |
IPR051907 | 51,907 | DoxX-like inner membrane-associated oxidoreductase | DoxX-like_oxidoreductase | Family | 37,356 | true | false | This family of proteins includes members that are putatively involved in the degradation of aromatic compounds and may function as oxidoreductases. Some proteins within this family are suggested to play a role in the detoxification of catechol, which is essential for growth and viability in certain environmental condit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33452"
] | [
"DoxX-like_oxidoreductase"
] | [
37356
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
800,
36184,
88,
10,
274
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | DoxX-like inner membrane-associated oxidoreductase | DoxX-like inner membrane-associated oxidoreductase | DoxX-like_oxidoreductase | 5 |
IPR051908 | 51,908 | Ribosomal-protein N-acetyltransferase | Ribosomal_N-acetyltransferase | Family | 33,683 | true | false | This family of proteins includes enzymes that catalyze the transfer of acetyl groups from acetyl coenzyme A to various substrates, including ribosomal proteins and nucleoid-associated DNA-binding proteins. Some members are known to modify specific ribosomal proteins, converting them into acetylated forms, which may aff... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43441"
] | [
"Ribosomal_N-acetyltransferase"
] | [
33683
] | 1 | [] | [] | [] | 0 | [
"1nsl",
"1s7f",
"1s7k",
"1s7l",
"1s7n",
"1z9u",
"2fck",
"2vzy",
"2vzz",
"3pzj",
"3r95",
"3r96",
"3r9e",
"3r9f",
"3r9g",
"3tcv"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctVCj30",
"unclassified sequences"
] | [
429,
30476,
2544,
1,
233
] | 5 | [
"Escherichia coli (strain K12)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Ribosomal-protein N-acetyltransferase | Ribosomal-protein N-acetyltransferase | Ribosomal_N-acetyltransferase | 9 |
IPR051909 | 51,909 | Membrane Fusion Protein Cation Efflux System | MFP_Cation_Efflux | Family | 25,586 | true | false | This family of proteins is involved in the transport of metal cations across cellular membranes, conferring resistance to various heavy metals such as copper, silver, zinc, nickel, cobalt, and cadmium. Members of this family are typically part of larger efflux systems that actively expel toxic metal ions from the cell,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30097"
] | [
"MFP_Cation_Efflux"
] | [
25586
] | 1 | [] | [] | [] | 0 | [
"3h94",
"3lnn",
"3ne5",
"3ooc",
"3opo",
"3ow7",
"3t51",
"3t53",
"3t56",
"4dnr",
"4dnt",
"4dop",
"5a4g"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
25090,
45,
1,
450
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Membrane Fusion Protein Cation Efflux System | Membrane Fusion Protein Cation Efflux System | MFP_Cation_Efflux | 3 |
IPR051910 | 51,910 | ComF/GntX DNA utilization and transformation protein | ComF/GntX_DNA_util-trans | Family | 26,283 | true | false | This family of proteins is associated with bacterial competence for DNA uptake, suggesting a role in transformation processes. Members of this family are also implicated in gluconate metabolism, which indicates a potential involvement in the utilization of extracellular DNA as a nutrient. The proteins within this famil... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47505"
] | [
"ComF/GntX_DNA_util-trans"
] | [
26283
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
23,
25749,
13,
2,
496
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ComF/GntX DNA utilization and transformation protein | ComF/GntX DNA utilization and transformation protein | ComF/GntX_DNA_util-trans | 3 |
IPR051911 | 51,911 | Short-chain Dehydrogenases/Reductases (SDR) | SDR_oxidoreductase | Family | 35,836 | true | false | The Short-chain Dehydrogenases/Reductases (SDR) family comprises enzymes with oxidoreductase activity, involved in various biosynthetic pathways. Members of the family participate in the synthesis of secondary metabolites such as botcinic acid, calbistrin A, and cladofulvin, which have roles in plant virulence, potenti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43976"
] | [
"SDR_oxidoreductase"
] | [
35836
] | 1 | [
"REACTOME"
] | [
"R-SPO-193144"
] | [
"REACTOME:R-SPO-193144"
] | 1 | [
"3m1a",
"3u9l"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Punavirus P1",
"metagenomes"
] | [
200,
26038,
9445,
1,
152
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
5,
3
] | 2 | true | Family | Short-chain Dehydrogenases/Reductases (SDR) | Short-chain Dehydrogenases/Reductases (SDR) | SDR_oxidoreductase | 9 |
IPR051912 | 51,912 | Alkylbase DNA Glycosylase/Transcriptional Activator | Alkylbase_DNA_Glycosylase/TA | Family | 26,233 | true | false | This family of proteins is involved in the cellular response to DNA damage, specifically alkylation lesions. Members of this family function as DNA glycosylases that recognize and excise various alkylated bases from DNA, thereby initiating the base excision repair (BER) pathway. These enzymes hydrolyze the N-glycosidic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43003"
] | [
"Alkylbase_DNA_Glycosylase/TA"
] | [
26233
] | 1 | [
"EC"
] | [
"3.2.2.21"
] | [
"EC:3.2.2.21"
] | 1 | [
"1diz",
"1mpg",
"1pvs",
"2h56",
"2jhj",
"2jhn",
"2yg8",
"2yg9",
"3cvs",
"3cvt",
"3cw7",
"3cwa",
"3cws",
"3cwt",
"3cwu",
"3d4v",
"3ogd",
"3oh6",
"3oh9",
"3s6i",
"4b21",
"4b22",
"4b23",
"4b24",
"4hsb"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
462,
22591,
2826,
18,
336
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
16,
1,
1,
7,
1,
2,
8
] | 7 | true | Family | Alkylbase DNA Glycosylase/Transcriptional Activator | Alkylbase DNA Glycosylase/Transcriptional Activator | Alkylbase_DNA_Glycosylase/TA | 8 |
IPR051913 | 51,913 | Glycosyl Hydrolase 2 Domain-Containing Protein | GH2_Domain-Containing | Family | 26,277 | true | false | This family of proteins exhibits hydrolytic activity on glycosidic bonds. Members are involved in the degradation of various glycosides, including those with beta-galactosidic and beta-glucuronidic linkages. They catalyze the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides, as well ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42732"
] | [
"GH2_Domain-Containing"
] | [
26277
] | 1 | [
"EC"
] | [
"3.2.1"
] | [
"EC:3.2.1"
] | 1 | [
"3cmg",
"3fn9",
"3gm8",
"4cu6",
"4cu7",
"4cu8",
"4cuc",
"4ypj",
"5dmy",
"5euv",
"5ldr",
"5t98",
"5t99",
"5t9a",
"5t9g",
"5uj6",
"5z1a",
"6b6l",
"6d1n",
"6d1p",
"6d41",
"6d50",
"6d6w",
"6d7f",
"6d7j",
"6d8g",
"6dxu",
"6ed1",
"6hpd",
"6mvf",
"6mvg",
"6mvh"... | 56 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
205,
23233,
2496,
3,
340
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glycosyl Hydrolase 2 Domain-Containing Protein | Glycosyl Hydrolase 2 Domain-Containing Protein | GH2_Domain-Containing | 5 |
IPR051914 | 51,914 | FAD-linked Oxidoreductase/Transferase Type 4 | FAD-linked_OxidoTrans_Type4 | Family | 20,741 | true | false | This family of proteins includes enzymes that are involved in oxidative reactions of various substrates such as glycolate and D-lactate. Members of this family function as oxidoreductases, often utilizing FAD as a cofactor. They are involved in metabolic pathways where they catalyze the oxidation of specific substrates... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42934"
] | [
"FAD-linked_OxidoTrans_Type4"
] | [
20741
] | 1 | [] | [] | [] | 0 | [
"7qh2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
258,
19898,
41,
1,
543
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | FAD-linked Oxidoreductase/Transferase Type 4 | FAD-linked Oxidoreductase/Transferase Type 4 | FAD-linked_OxidoTrans_Type4 | 1 |
IPR051915 | 51,915 | Cellulose Degradation Glycosyl Hydrolase 3 | Cellulose_Degrad_GH3 | Family | 27,376 | true | false | The Glycosyl Hydrolase 3 family encompasses enzymes that play a crucial role in the degradation of cellulosic biomass. Members of this family, including beta-glucosidases, catalyze the hydrolysis of terminal, non-reducing beta-D-glucosyl residues, which results in the release of beta-D-glucose. This reaction is signifi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30620"
] | [
"Cellulose_Degrad_GH3"
] | [
27376
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.2.1.21",
"PWY-3121",
"PWY-5176",
"PWY-6002",
"PWY-6788",
"PWY-7091",
"PWY-7092",
"PWY-7913"
] | [
"EC:3.2.1.21",
"METACYC:PWY-3121",
"METACYC:PWY-5176",
"METACYC:PWY-6002",
"METACYC:PWY-6788",
"METACYC:PWY-7091",
"METACYC:PWY-7092",
"METACYC:PWY-7913"
] | 8 | [
"1ex1",
"1ieq",
"1iev",
"1iew",
"1iex",
"1j8v",
"1lq2",
"1x38",
"1x39",
"3rrx",
"3u48",
"3u4a",
"3usz",
"3ut0",
"3wlh",
"3wli",
"3wlj",
"3wlk",
"3wll",
"3wlm",
"3wln",
"3wlo",
"3wlp",
"3wlq",
"3wlr",
"4zo6",
"4zo7",
"4zo8",
"4zo9",
"4zoa",
"4zob",
"4zoc"... | 100 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
246,
17807,
9176,
1,
146
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
50,
1,
23,
63
] | 4 | true | Family | Cellulose Degradation Glycosyl Hydrolase 3 | Cellulose Degradation Glycosyl Hydrolase 3 | Cellulose_Degrad_GH3 | 4 |
IPR051916 | 51,916 | GPI-anchor maturation lipid remodeler | GPI-anchor_lipid_remodeler | Family | 24,838 | true | false | This family of proteins is involved in the process of lipid remodeling, which is a crucial step during the maturation of glycosylphosphatidylinositol (GPI) anchors. Members of this family are required for the replacement of the diacylglycerol moiety with ceramides in GPI-anchor maturation, a modification that is essent... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14859"
] | [
"GPI-anchor_lipid_remodeler"
] | [
24838
] | 1 | [] | [] | [] | 0 | [
"4ruw"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
60,
20157,
4319,
7,
295
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosacch... | [
9,
1,
4,
1,
1,
6,
5,
1,
1,
4
] | 10 | true | Family | GPI-anchor maturation lipid remodeler | GPI-anchor maturation lipid remodeler | GPI-anchor_lipid_remodeler | 1 |
IPR051917 | 51,917 | Transposase/Integrase Enzymes | Transposase-Integrase | Family | 22,277 | true | false | This family of proteins includes transposases and integrases, which are enzymes that catalyze the movement of DNA segments within genomes. Transposases are responsible for the cut-and-paste mechanism of transposable elements, allowing for the insertion of DNA at new genomic locations. Integrases typically facilitate th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10948"
] | [
"Transposase-Integrase"
] | [
22277
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"other sequences",
"unclassified sequences"
] | [
8,
21790,
30,
21,
2,
426
] | 6 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
3,
1
] | 2 | true | Family | Transposase/Integrase Enzymes | Transposase/Integrase Enzymes | Transposase-Integrase | 2 |
IPR051918 | 51,918 | Serine/threonine-protein phosphatase CPPED1 | STPP_CPPED1 | Family | 16,708 | true | false | The CPPED1 family is part of the metallophosphoesterase superfamily and includes serine/threonine-protein phosphatases. Members of the CPPED1 family are involved in the dephosphorylation of AKT kinase family members, particularly at 'Ser-473'. This regulatory activity is crucial for controlling cell cycle progression a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43143"
] | [
"STPP_CPPED1"
] | [
16708
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.16",
"R-DRE-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695",
"R-XTR-6798695"
] | [
"EC:3.1.3.16",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695",
"REACTOME:R-XTR-6798695"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
194,
14252,
2041,
15,
206
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
3
] | 4 | true | Family | Serine/threonine-protein phosphatase CPPED1 | Serine/threonine-protein phosphatase CPPED1 | STPP_CPPED1 | 4 |
IPR051919 | 51,919 | Tungsten-dependent aldehyde ferredoxin oxidoreductase | W-dependent_AOR | Family | 6,395 | true | true | This family of proteins includes enzymes that are involved in the oxidative decarboxylation of aldehydes into their corresponding carboxylic acids, utilising ferredoxin as an electron acceptor. Members of this family are characterised by the presence of tungsten in their active sites and are known to participate in var... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30038"
] | [
"W-dependent_AOR"
] | [
6395
] | 1 | [] | [] | [] | 0 | [
"1aor",
"1b25",
"1b4n",
"4z3w",
"4z3x",
"4z3y",
"4z3z",
"4z40",
"6x1o",
"6x6u",
"8c0z",
"9g7j",
"9mqx"
] | 13 | [
"PUB00161750",
"PUB00161752"
] | [
"1907273",
"8390467"
] | [
"The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase. Evidence for its participation in a unique glycolytic pathway.",
"Characterization of a novel tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperth... | [
1991,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1884,
3696,
6,
809
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Tungsten-dependent aldehyde ferredoxin oxidoreductase | Tungsten-dependent aldehyde ferredoxin oxidoreductase | W-dependent_AOR | 8 |
IPR051920 | 51,920 | Molybdopterin Adenylyltransferase/MoaC-Related | MPT_Adenylyltrnsfr/MoaC-Rel | Family | 14,133 | true | false | This family of proteins includes enzymes involved in the biosynthesis of the molybdenum cofactor, which is essential for the activity of various molybdoenzymes. Members of this family are responsible for the adenylation of molybdopterin, a key step in the formation of the molybdenum cofactor. Additionally, some bifunct... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43764"
] | [
"MPT_Adenylyltrnsfr/MoaC-Rel"
] | [
14133
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"2.7.7.75",
"PWY-8167",
"PWY-8171"
] | [
"EC:2.7.7.75",
"METACYC:PWY-8167",
"METACYC:PWY-8171"
] | 3 | [
"1di6",
"1di7",
"1eav",
"1ihc",
"1jlj",
"1o8n",
"1o8o",
"1o8q",
"1uux",
"1uuy",
"2f7w",
"2f7y",
"2g2c",
"2g4r",
"2is8",
"2pbq",
"2qq1",
"3k6a",
"3mch",
"3mci",
"3mcj",
"3oi9",
"3pzy",
"3rfq",
"3tcr",
"4nwo",
"4twg",
"4xcw",
"8byr",
"8cuu",
"8cuv",
"8cuw"... | 32 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
19,
13165,
637,
312
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Zea mays"
] | [
1,
1,
3,
1,
2,
4
] | 6 | true | Family | Molybdopterin Adenylyltransferase/MoaC-Related | Molybdopterin Adenylyltransferase/MoaC-Related | MPT_Adenylyltrnsfr/MoaC-Rel | 9 |
IPR051921 | 51,921 | ABC transporter osmolyte uptake ATP-binding protein | ABC_osmolyte_uptake_ATP-bind | Family | 16,317 | true | false | This family of proteins is involved in the transport of various osmolytes across cellular membranes. Members of this family are part of ATP-binding cassette (ABC) transporter complexes, which are responsible for the energy-dependent uptake of specific substrates. These substrates include trimethylamine N-oxide (TMAO), ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43869"
] | [
"ABC_osmolyte_uptake_ATP-bind"
] | [
16317
] | 1 | [
"EC"
] | [
"7.6.2.9"
] | [
"EC:7.6.2.9"
] | 1 | [
"7ahc",
"7ahd",
"7ahe",
"7ahh"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
143,
15908,
42,
224
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ABC transporter osmolyte uptake ATP-binding protein | ABC transporter osmolyte uptake ATP-binding protein | ABC_osmolyte_uptake_ATP-bind | 3 |
IPR051922 | 51,922 | Bacterial Sporulation-Associated | Bact_Sporulation_Assoc | Family | 11,838 | true | false | The protein family in question appears to be involved in bacterial sporulation processes. Members of this family may influence the activity or stability of sigma-G, a transcription factor critical for sporulation, and are likely required for the engulfment stage of spore formation. Some proteins within the family are s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30032"
] | [
"Bact_Sporulation_Assoc"
] | [
11838
] | 1 | [] | [] | [] | 0 | [
"4rwr",
"5i1t",
"5j6q",
"5j72",
"5txu",
"7acx",
"7acy",
"7acz",
"7qgq",
"8bby",
"9f8e",
"9f8f"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
86,
11638,
4,
3,
107
] | 5 | [] | [] | 0 | true | Family | Bacterial Sporulation-Associated | Bacterial Sporulation-Associated | Bact_Sporulation_Assoc | 2 |
IPR051923 | 51,923 | Glycosyl Hydrolase Family 39 | Glycosyl_Hydrolase_39 | Family | 10,915 | true | false | The glycosyl hydrolase 39 family encompasses enzymes with diverse functions including the degradation of glycosaminoglycans and the hydrolysis of xylo-oligosaccharides. Members of the family such as beta-xylosidases are involved in the breakdown of xylan into xylose units, playing a role in the utilization of plant bio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12631"
] | [
"Glycosyl_Hydrolase_39"
] | [
10915
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1",
"R-CFA-2024096",
"R-CFA-2024101",
"R-DME-2024096",
"R-DME-2024101",
"R-HSA-2024096",
"R-HSA-2024101",
"R-HSA-2206302",
"R-HSA-9953038",
"R-MMU-2024096",
"R-MMU-2024101"
] | [
"EC:3.2.1",
"REACTOME:R-CFA-2024096",
"REACTOME:R-CFA-2024101",
"REACTOME:R-DME-2024096",
"REACTOME:R-DME-2024101",
"REACTOME:R-HSA-2024096",
"REACTOME:R-HSA-2024101",
"REACTOME:R-HSA-2206302",
"REACTOME:R-HSA-9953038",
"REACTOME:R-MMU-2024096",
"REACTOME:R-MMU-2024101"
] | 11 | [
"1px8",
"1uhv",
"1w91",
"2bfg",
"2bs9",
"3w81",
"3w82",
"4ekj",
"4kgj",
"4kgl",
"4kh2",
"4m29",
"4mj2",
"4mj4",
"4obr",
"4obs",
"4zn2",
"5bx9",
"5bxa",
"5jvk",
"5ndx",
"5z3k",
"6i6r",
"6i6x",
"6uqj",
"6yyh",
"6yyi",
"8i0j",
"8i0x",
"9g17",
"9g18"
] | 31 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
18,
9041,
4,
1698,
154
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
9,
8,
3
] | 5 | true | Family | Glycosyl Hydrolase Family 39 | Glycosyl Hydrolase Family 39 | Glycosyl_Hydrolase_39 | 7 |
IPR051925 | 51,925 | RNA-binding domain-containing protein | RNA-binding_domain | Family | 11,283 | true | false | This family of proteins is involved in RNA binding, which suggests a role in various RNA-related processes such as RNA metabolism, regulation of gene expression, or RNA splicing. Members of this family may interact with RNA molecules to influence their stability, structure, or function, and could be implicated in cellu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40065"
] | [
"RNA-binding_domain"
] | [
11283
] | 1 | [] | [] | [] | 0 | [
"1jo0",
"1ln4",
"1rq8"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
690,
10439,
15,
139
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | RNA-binding domain-containing protein | RNA-binding domain-containing protein | RNA-binding_domain | 9 |
IPR051926 | 51,926 | Alanine Aminotransferase | Ala_Aminotransferase | Family | 11,849 | true | false | This family of proteins is involved in amino acid metabolism, specifically in the biosynthesis and degradation of alanine. Members of this family function as aminotransferases, enzymes that catalyze the transfer of an amino group from an amino acid to a keto acid. The primary reaction mediated by these enzymes is the t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43488"
] | [
"Ala_Aminotransferase"
] | [
11849
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.6.1.2",
"PWY-7115",
"PWY-7117",
"PWY-7383",
"PWY-8188",
"PWY-8189"
] | [
"EC:2.6.1.2",
"METACYC:PWY-7115",
"METACYC:PWY-7117",
"METACYC:PWY-7383",
"METACYC:PWY-8188",
"METACYC:PWY-8189"
] | 6 | [
"1xi9",
"4cvq"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
202,
11467,
24,
156
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Alanine Aminotransferase | Alanine Aminotransferase | Ala_Aminotransferase | 1 |
IPR051927 | 51,927 | Zinc Chaperone and cDPG Synthetase | Zn_Chap_cDPG_Synth | Family | 13,883 | true | false | This family of proteins includes zinc chaperones and cyclic 2,3-diphosphoglycerate synthetases. The zinc chaperones are involved in the direct transfer of zinc cofactors to target proteins, activating them. This transfer occurs from a CXCC motif within the GTPase domain to the zinc binding site of the target proteins a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43603"
] | [
"Zn_Chap_cDPG_Synth"
] | [
13883
] | 1 | [
"EC"
] | [
"3.6.5.-"
] | [
"EC:3.6.5.-"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteria",
"unclassified sequences"
] | [
10961,
2233,
659,
30
] | 4 | [] | [] | 0 | true | Family | Zinc Chaperone and cDPG Synthetase | Zinc Chaperone and cDPG Synthetase | Zn_Chap_cDPG_Synth | 8 |
IPR051928 | 51,928 | NorD/CobT | NorD/CobT | Family | 10,135 | true | false | The NorD/CobT protein family is involved in various aspects of bacterial metabolism. The majority of the family members, such as NorD from different Brucella species, are part of the norEFCBQD operon, which encodes nitric oxide reductase. These proteins are essential virulence factors likely involved in the detoxificat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR41248"
] | [
"NorD/CobT"
] | [
10135
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
63,
9811,
28,
13,
220
] | 5 | [] | [] | 0 | true | Family | NorD/CobT | NorD/CobT | NorD/CobT | 1 |
IPR051930 | 51,930 | Flavodoxin/Ferredoxin--NADP Reductase | FNR_type-1 | Family | 10,311 | true | false | This family of proteins is involved in electron transport, facilitating the transfer of electrons between flavodoxin or ferredoxin and NADPH. Members of this family are crucial for the activation of various enzymes that are essential in metabolic processes, particularly under anaerobic conditions. These enzymes include... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47878"
] | [
"FNR_type-1"
] | [
10311
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC"
] | [
"1.18.1.2",
"1.19.1.1",
"PWY-101",
"PWY-8271"
] | [
"EC:1.18.1.2",
"EC:1.19.1.1",
"METACYC:PWY-101",
"METACYC:PWY-8271"
] | 4 | [
"1a8p",
"1fdr",
"2bgi",
"2bgj",
"2qdx",
"2vnh",
"2vni",
"2vnj",
"2vnk",
"2xnj",
"3crz",
"3fpk",
"4b4d",
"4f7d",
"4fk8",
"4k1x",
"5thx",
"5tr9",
"5ufa",
"6rr3",
"6rra",
"8dos",
"9gxb",
"9gxc"
] | 24 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"metagenomes"
] | [
10064,
20,
105,
122
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flavodoxin/Ferredoxin--NADP Reductase | Flavodoxin/Ferredoxin--NADP Reductase | FNR_type-1 | 9 |
IPR051932 | 51,932 | Bacterial Stress Response Regulators | Bact_StressResp_Reg | Family | 12,607 | true | false | The protein family is involved in the environmental signaling branch of the general stress response in bacteria. Members of the family include blue-light photoreceptors that share spectroscopical features with plant phototropins and are involved in the reversible formation of a blue-shifted photoproduct. This photoprod... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33745"
] | [
"Bact_StressResp_Reg"
] | [
12607
] | 1 | [] | [] | [] | 0 | [
"2mwg",
"2vy9",
"3ztb",
"3zxn",
"6jhk",
"6qcm",
"7b0u",
"7o0i"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Russula earlei",
"Stenosarchaea group",
"metagenomes"
] | [
12514,
1,
69,
23
] | 4 | [] | [] | 0 | true | Family | Bacterial Stress Response Regulators | Bacterial Stress Response Regulators | Bact_StressResp_Reg | 6 |
IPR051933 | 51,933 | Bacterial Resuscitation-promoting factor RpfB | Resuscitation_pf_RpfB | Family | 10,244 | true | false | The RpfB family proteins are known to play a crucial role in the resuscitation of dormant cells, particularly in the context of chronic tuberculosis. They exhibit peptidoglycan hydrolytic activity, which is effective even at picomolar concentrations and does not significantly impact actively growing cells. The enzymati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39160"
] | [
"Resuscitation_pf_RpfB"
] | [
10244
] | 1 | [] | [] | [] | 0 | [
"4wjt",
"4wli",
"4wlk",
"5e27"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
9980,
51,
117,
96
] | 4 | [] | [] | 0 | true | Family | Bacterial Resuscitation-promoting factor RpfB | Bacterial Resuscitation-promoting factor RpfB | Resuscitation_pf_RpfB | 4 |
IPR051934 | 51,934 | Bacteriophage Tail Fiber Structural Protein | Phage_Tail_Fiber_Structural | Family | 11,493 | true | false | This family of proteins includes structural components of bacteriophage tail fibers, which are involved in the initial stages of bacterial infection. Members of this family are responsible for recognizing and binding to specific bacterial receptors, determining the host range of the phage. The tail fibers can be divide... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35191"
] | [
"Phage_Tail_Fiber_Structural"
] | [
11493
] | 1 | [] | [] | [] | 0 | [
"2xgf",
"5yvq",
"6cl5",
"6cl6",
"6ct8",
"6cu2",
"8ju3",
"9cuy",
"9ki1",
"9mjn"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Viruses",
"metagenomes"
] | [
11000,
12,
467,
14
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Bacteriophage Tail Fiber Structural Protein | Bacteriophage Tail Fiber Structural Protein | Phage_Tail_Fiber_Structural | 1 |
IPR051935 | 51,935 | Hydroxysteroid dehydrogenase-like protein 2 | HSDL2 | Family | 8,270 | true | false | This family of proteins is part of the short-chain dehydrogenases/reductases (SDR) superfamily. Despite their classification, these proteins are noted for lacking steroid dehydrogenase activity, which is typically associated with the SDR family. The exact biological function of these proteins remains unclear, but their... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42808"
] | [
"HSDL2"
] | [
8270
] | 1 | [] | [] | [] | 0 | [
"3e03",
"3kvo",
"3sc4"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
166,
3974,
3967,
163
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
1,
1,
4,
5,
1,
7
] | 7 | true | Family | Hydroxysteroid dehydrogenase-like protein 2 | Hydroxysteroid dehydrogenase-like protein 2 | HSDL2 | 2 |
IPR051937 | 51,937 | R3H domain-containing | R3H_domain_containing | Family | 11,469 | true | false | The R3H domain-containing protein family is involved in various cellular processes. Members of this family are implicated in the regulation of germline mitosis, karyosome formation, and the establishment of dorsoventral polarity in eggs and embryos. They play a role in the localization and translation of grk mRNA in oo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15672"
] | [
"R3H_domain_containing"
] | [
11469
] | 1 | [] | [] | [] | 0 | [
"1whr"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
4,
11465
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
1,
76,
5,
20,
18,
1,
12,
23,
1,
57
] | 11 | true | Family | R3H domain-containing | R3H domain-containing | R3H_domain_containing | 5 |
IPR051939 | 51,939 | Glycosyltransferase 41/O-GlcNAc transferase | Glycosyltr_41/O-GlcNAc_trsf | Family | 5,810 | true | false | The glycosyltransferase 41 family is characterized by enzymes that modify proteins through the addition of sugar moieties, impacting various biological processes. Members of the O-GlcNAc transferase subfamily, such as SPINDLY, are involved in the gibberellin signaling pathway, affecting plant growth and development. Th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44835"
] | [
"Glycosyltr_41/O-GlcNAc_trsf"
] | [
5810
] | 1 | [
"EC",
"METACYC"
] | [
"2.4.1.255",
"PWY-7437"
] | [
"EC:2.4.1.255",
"METACYC:PWY-7437"
] | 2 | [
"3q3e",
"3q3h",
"3q3i",
"5djs",
"7y4i",
"8dtf",
"8dtg",
"8dth",
"8dti",
"8j30",
"8p0o",
"8p0p",
"8p0q"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2,
4293,
1409,
106
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
2,
4
] | 3 | true | Family | Glycosyltransferase 41/O-GlcNAc transferase | Glycosyltransferase 41/O-GlcNAc transferase | Glycosyltr_41/O-GlcNAc_trsf | 8 |
IPR051940 | 51,940 | Chitin-binding developmental regulator | Chitin_bind-dev_reg | Family | 12,225 | true | false | This family of proteins is involved in various developmental processes, including the regulation of shape and survival during different life stages. Members of this family are characterized by their ability to bind chitin, which is a key component in the structure of cuticles and extracellular matrices. They play criti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23301"
] | [
"Chitin_bind-dev_reg"
] | [
12225
] | 1 | [] | [] | [] | 0 | [
"4z4a",
"8in3",
"8in4",
"8in6"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Naldaviricetes"
] | [
2,
63,
12142,
18
] | 4 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
5,
78
] | 2 | true | Family | Chitin-binding developmental regulator | Chitin-binding developmental regulator | Chitin_bind-dev_reg | 6 |
IPR051942 | 51,942 | DENN domain-containing protein 2 | DENN_domain_containing_2 | Family | 9,236 | true | false | This family of proteins functions as guanine nucleotide exchange factors (GEFs) primarily activating RAB9A and RAB9B. They facilitate the conversion of these Rab proteins from an inactive GDP-bound state to an active GTP-bound form. Members of this family are involved in various cellular processes, including endosomal ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15288"
] | [
"DENN_domain_containing_2"
] | [
9236
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8876198",
"R-MMU-8876198"
] | [
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9236
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
17,
18,
11,
8,
21,
39
] | 7 | true | Family | DENN domain-containing protein 2 | DENN domain-containing protein 2 | DENN_domain_containing_2 | 2 |
IPR051943 | 51,943 | TRAFAC Dynamin-like GTPase | TRAFAC_Dynamin-like_GTPase | Family | 9,360 | true | false | This family of proteins includes members that are part of the TRAFAC class dynamin-like GTPase superfamily, specifically the Dynamin/Fzo/YdjA family. These proteins are involved in membrane remodeling processes. One member, a probable transmembrane GTPase, is implicated in determining thylakoid and chloroplast morpholo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43681"
] | [
"TRAFAC_Dynamin-like_GTPase"
] | [
9360
] | 1 | [] | [] | [] | 0 | [
"5owv",
"5oxf",
"6j72",
"6j73"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"metagenomes"
] | [
5606,
3696,
10,
48
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
4,
6,
2,
1,
3,
5,
8
] | 8 | true | Family | TRAFAC Dynamin-like GTPase | TRAFAC Dynamin-like GTPase | TRAFAC_Dynamin-like_GTPase | 1 |
IPR051944 | 51,944 | BEACH domain-containing protein | BEACH_domain_protein | Family | 8,187 | true | false | This family of proteins is involved in various cellular processes including autophagy, protein sorting, cell morphogenesis, and membrane fusion. Members of this family play critical roles in the regulation of antigen presentation in dendritic cells, B-cell survival, cytokinesis, phagocytosis, osmoregulation, and brain ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46108"
] | [
"BEACH_domain_protein"
] | [
8187
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8187
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
14,
4,
40,
2,
9,
11,
1,
6,
9,
1,
14
] | 11 | true | Family | BEACH domain-containing protein | BEACH domain-containing protein | BEACH_domain_protein | 7 |
IPR051945 | 51,945 | RRM MRD1 RNA Processing and Ribosome Biogenesis | RRM_MRD1_RNA_proc_ribogen | Family | 8,333 | true | false | The RRM MRD1 family is involved in various aspects of RNA processing and ribosome biogenesis. Members of the family play a role in embryo pre-implantation development and are implicated in pre-rRNA processing, which is essential for the production of mature ribosomal RNA and the subsequent assembly of ribosomal subunit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48039"
] | [
"RRM_MRD1_RNA_proc_ribogen"
] | [
8333
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6791226",
"R-SPO-72163",
"R-SPO-72203"
] | [
"REACTOME:R-HSA-6791226",
"REACTOME:R-SPO-72163",
"REACTOME:R-SPO-72203"
] | 3 | [
"1x4h"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pithovirus LCPAC302",
"Pseudomonadati"
] | [
8330,
1,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
4,
3,
5,
8,
4,
2,
8,
8,
2,
3,
4
] | 12 | true | Family | RRM MRD1 RNA Processing and Ribosome Biogenesis | RRM MRD1 RNA Processing and Ribosome Biogenesis | RRM_MRD1_RNA_proc_ribogen | 5 |
IPR051946 | 51,946 | Intracellular Trafficking Regulator | Intracell_Traff-Reg | Family | 6,926 | true | false | This family of proteins is involved in intracellular trafficking and the regulation of endosome-to-lysosome pathways. They are essential for the axonal transport of various cargos, including mitochondria, growth factors, and neurotransmitter receptors, to their respective destinations within the cell. Members of this f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15751"
] | [
"Intracell_Traff-Reg"
] | [
6926
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9013419",
"R-DME-9013425",
"R-HSA-6802952",
"R-HSA-9013419",
"R-HSA-9013425",
"R-MMU-9013419",
"R-MMU-9013425",
"R-RNO-9013419"
] | [
"REACTOME:R-DME-9013419",
"REACTOME:R-DME-9013425",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-9013419",
"REACTOME:R-HSA-9013425",
"REACTOME:R-MMU-9013419",
"REACTOME:R-MMU-9013425",
"REACTOME:R-RNO-9013419"
] | 8 | [
"9dgv",
"9e2p"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6926
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
47,
6,
19,
22,
17
] | 6 | true | Family | Intracellular Trafficking Regulator | Intracellular Trafficking Regulator | Intracell_Traff-Reg | 9 |
IPR051947 | 51,947 | Sentrin-specific protease | Sentrin-specific_protease | Family | 6,802 | true | false | This family of proteins includes sentrin-specific proteases that are involved in the post-translational modification of proteins through the process of SUMOylation, where small ubiquitin-like modifier (SUMO) proteins are attached to target proteins. Members of this family are responsible for the cleavage of SUMO2 and S... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46896"
] | [
"Sentrin-specific_protease"
] | [
6802
] | 1 | [
"EC"
] | [
"3.4.22.-"
] | [
"EC:3.4.22.-"
] | 1 | [
"3eay",
"7r2e"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aeromicrobium halocynthiae",
"Eukaryota"
] | [
1,
6801
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
18,
13,
13,
14,
2,
15,
1
] | 7 | true | Family | Sentrin-specific protease | Sentrin-specific protease | Sentrin-specific_protease | 8 |
IPR051949 | 51,949 | Cation Transport P-type ATPase | Cation_Transport_ATPase | Family | 5,435 | true | false | This family of proteins includes P-type ATPases that are involved in the transport of various metal ions across cellular membranes. Members of this family are primarily responsible for the homeostasis of heavy metals, such as zinc, cobalt, nickel, and cadmium, by either importing or exporting these ions to maintain cel... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43079"
] | [
"Cation_Transport_ATPase"
] | [
5435
] | 1 | [
"EC"
] | [
"7.2.2.-"
] | [
"EC:7.2.2.-"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
96,
4392,
914,
33
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
6,
7
] | 3 | true | Family | Cation Transport P-type ATPase | Cation Transport P-type ATPase | Cation_Transport_ATPase | 3 |
IPR051950 | 51,950 | Developmental regulator and protease inhibitor | Dev_reg/Prot_inhib | Family | 6,738 | true | false | This family of proteins includes members that are involved in developmental processes, such as eye and limb formation, and osteoblast differentiation. Some family members are known to interact with signaling pathways, for instance, by binding and stabilizing Wnt signaling proteins to facilitate gradient formation durin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12352"
] | [
"Dev_reg/Prot_inhib"
] | [
6738
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
7,
6731
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
60,
7,
7,
9,
7
] | 6 | true | Family | Developmental regulator and protease inhibitor | Developmental regulator and protease inhibitor | Dev_reg/Prot_inhib | 3 |
IPR051952 | 51,952 | Golgi-associated and autophagy-related protein | Golgi-autophagy_related | Family | 4,944 | true | false | This family of proteins is involved in various aspects of intracellular vesicular transport, particularly associated with the Golgi apparatus and autophagy processes. Members of this family play roles in maintaining the structure of the Golgi, mediating vesicle formation and trafficking between endosomes and the Golgi,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23157"
] | [
"Golgi-autophagy_related"
] | [
4944
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6811440",
"R-HSA-6811440",
"R-MMU-6811440",
"R-SCE-6811440"
] | [
"REACTOME:R-CEL-6811440",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440",
"REACTOME:R-SCE-6811440"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)",
"metagenomes"
] | [
17,
4923,
1,
3
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
5,
7,
9,
10,
1,
8,
1
] | 8 | true | Family | Golgi-associated and autophagy-related protein | Golgi-associated and autophagy-related protein | Golgi-autophagy_related | 5 |
IPR051953 | 51,953 | Plant secondary wall-associated transcription factors | Plant_SW-associated_TFs | Family | 8,760 | true | false | This family of proteins includes transcription factors that play crucial roles in plant development and response to environmental stimuli. Members of this family are involved in the regulation of secondary wall biosynthesis, particularly in fibers and vessels, by binding to specific DNA consensus sequences and activati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47997"
] | [
"Plant_SW-associated_TFs"
] | [
8760
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8760
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
98,
49,
113
] | 3 | true | Family | Plant secondary wall-associated transcription factors | Plant secondary wall-associated transcription factors | Plant_SW-associated_TFs | 8 |
IPR051954 | 51,954 | tRNA (32-2'-O)-methyltransferase regulator THADA | tRNA_methyltransferase_THADA | Family | 6,021 | true | false | The THADA family proteins are involved in the post-transcriptional modification of tRNAs and energy homeostasis. Members of this family function in conjunction with specific methyltransferases to methylate the 2'-O-ribose of nucleotides at position 32 in the anticodon loop of tRNAs, a modification important for the sta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14387"
] | [
"tRNA_methyltransferase_THADA"
] | [
6021
] | 1 | [
"REACTOME"
] | [
"R-HSA-6782315"
] | [
"REACTOME:R-HSA-6782315"
] | 1 | [
"8y2o"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6021
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
2,
3,
3,
10,
1,
1,
5,
8,
1,
1,
8
] | 12 | true | Family | tRNA (32-2'-O)-methyltransferase regulator THADA | tRNA (32-2'-O)-methyltransferase regulator THADA | tRNA_methyltransferase_THADA | 6 |
IPR051955 | 51,955 | Pectinesterase Inhibitor | PME_Inhibitor | Family | 8,529 | true | false | This family of proteins includes inhibitors of pectin methylesterase (PME), which are involved in the modulation of PME activity and pectin methylesterification. These proteins play a crucial role in maintaining cell wall integrity, particularly in response to pathogenic attacks such as those from necrotrophic pathogen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31080"
] | [
"PME_Inhibitor"
] | [
8529
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
8529
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
95,
42,
45
] | 3 | true | Family | Pectinesterase Inhibitor | Pectinesterase Inhibitor | PME_Inhibitor | 8 |
IPR051956 | 51,956 | eIF2B Complex Subunit Epsilon | eIF2B_epsilon | Family | 5,656 | true | false | This family of proteins functions as components of the translation initiation factor 2B (eIF2B) complex. They possess guanine nucleotide exchange factor activity, catalyzing the exchange of GDP for GTP on the eIF2 gamma subunit. This activity is crucial for the initiation of protein synthesis by facilitating the bindin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45887"
] | [
"eIF2B_epsilon"
] | [
5656
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-72731",
"R-HSA-72731",
"R-MMU-72731",
"R-RNO-72731",
"R-SCE-72731",
"R-SPO-72731"
] | [
"REACTOME:R-DDI-72731",
"REACTOME:R-HSA-72731",
"REACTOME:R-MMU-72731",
"REACTOME:R-RNO-72731",
"REACTOME:R-SCE-72731",
"REACTOME:R-SPO-72731"
] | 6 | [
"1paq",
"2ful",
"2iu1",
"3d3m",
"3jui",
"5b04",
"6caj",
"6ezo",
"6i3m",
"6i7t",
"6jly",
"6jlz",
"6k71",
"6k72",
"6knd",
"6kne",
"6o81",
"6o85",
"6o9z",
"6qg0",
"6qg1",
"6qg2",
"6qg3",
"6qg5",
"6qg6",
"7d43",
"7d44",
"7d45",
"7d46",
"7f64",
"7f66",
"7f67"... | 41 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"marine sediment metagenome"
] | [
2,
5646,
3,
5
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
1,
3,
18,
3,
1,
5,
3,
1,
1,
12
] | 12 | true | Family | eIF2B Complex Subunit Epsilon | eIF2B Complex Subunit Epsilon | eIF2B_epsilon | 7 |
IPR051957 | 51,957 | Cysteine-rich secretory LCCL domain-containing protein | CRISP-LCCL_domain | Family | 5,067 | true | false | This family of proteins includes members that are known to promote matrix assembly. They are characterized by the presence of a cysteine-rich secretory LCCL domain. The LCCL domain is implicated in various biological processes, including cell adhesion, migration, and the organization of extracellular components. Member... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31331"
] | [
"CRISP-LCCL_domain"
] | [
5067
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-HSA-6798695",
"R-MMU-6798695"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695"
] | 3 | [
"1jbi"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bioreactor metagenome"
] | [
137,
4926,
4
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
5,
8,
2,
2,
8,
1
] | 6 | true | Family | Cysteine-rich secretory LCCL domain-containing protein | Cysteine-rich secretory LCCL domain-containing protein | CRISP-LCCL_domain | 1 |
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