interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052068 | 52,068 | GW182 domain-containing protein | GW182_domain | Family | 6,820 | true | false | This family of proteins is involved in RNA-mediated gene silencing mechanisms, including those mediated by micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Members of this family are essential for the miRNA-dependent translational repression and siRNA-dependent cleavage of target mRNAs. They function as scaffol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13020"
] | [
"GW182_domain"
] | [
6820
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-426496",
"R-DME-5578749",
"R-HSA-1912408",
"R-HSA-2559580",
"R-HSA-2559585",
"R-HSA-4086398",
"R-HSA-426496",
"R-HSA-5578749",
"R-HSA-5628897",
"R-HSA-5687128",
"R-HSA-8853884",
"R-HSA-8934593",
"R-HSA-8936459",
"R-HSA-8943723",
"R-HSA-8948700",
"R-HSA-8986944",
"R-HSA-9018519... | [
"REACTOME:R-DME-426496",
"REACTOME:R-DME-5578749",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-2559580",
"REACTOME:R-HSA-2559585",
"REACTOME:R-HSA-4086398",
"REACTOME:R-HSA-426496",
"REACTOME:R-HSA-5578749",
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-5687128",
"REACTOME:R-HSA-8853884",
"REACTOME:... | 27 | [
"2dkl",
"2wbr"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
6820
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
25,
1,
15,
25,
23
] | 5 | true | Family | GW182 domain-containing protein | GW182 domain-containing protein | GW182_domain | 4 |
IPR052069 | 52,069 | Calcium-regulated mRNA-binding domain-containing protein | Ca-reg_mRNA-binding_domain | Family | 4,771 | true | false | This family of proteins includes RNA-binding factors that are involved in the regulation of mRNA stability and the synthesis of histone variants. Members of this family have been shown to bind specifically to mRNA, including the 3'-UTR ends of histone H1 and H3.3 mRNAs, which encompasses the polyadenylation signal. Thi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12962"
] | [
"Ca-reg_mRNA-binding_domain"
] | [
4771
] | 1 | [] | [] | [] | 0 | [
"3aqq"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1947,
2808,
16
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
10,
5,
8
] | 5 | true | Family | Calcium-regulated mRNA-binding domain-containing protein | Calcium-regulated mRNA-binding domain-containing protein | Ca-reg_mRNA-binding_domain | 4 |
IPR052070 | 52,070 | ESCRT-I complex UEV domain-containing protein | ESCRT-I_UEV_domain | Family | 6,763 | true | false | This family of proteins is involved in the endosomal sorting complex required for transport (ESCRT) pathway, specifically as components of the ESCRT-I complex. They play a crucial role in the sorting of ubiquitinated cargo into multivesicular bodies (MVBs), which is essential for vesicular trafficking processes. Member... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23306"
] | [
"ESCRT-I_UEV_domain"
] | [
6763
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-917729",
"R-HSA-162588",
"R-HSA-174490",
"R-HSA-917729",
"R-HSA-9610379",
"R-HSA-9615710",
"R-MMU-917729",
"R-RNO-917729",
"R-SCE-917729"
] | [
"REACTOME:R-DDI-917729",
"REACTOME:R-HSA-162588",
"REACTOME:R-HSA-174490",
"REACTOME:R-HSA-917729",
"REACTOME:R-HSA-9610379",
"REACTOME:R-HSA-9615710",
"REACTOME:R-MMU-917729",
"REACTOME:R-RNO-917729",
"REACTOME:R-SCE-917729"
] | 9 | [
"1kpp",
"1kpq",
"1m4p",
"1m4q",
"1s1q",
"1uzx",
"2caz",
"2f0r",
"2f66",
"2f6m",
"2p22",
"3obq",
"3obs",
"3obu",
"3obx",
"3p9g",
"3p9h",
"3r3q",
"3r42",
"4eje",
"4yc1",
"4zny",
"5vkg",
"6ud0",
"6vme",
"7nlc",
"7zlx"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6763
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
3,
2,
6,
9,
1,
3,
6,
1,
8
] | 11 | true | Family | ESCRT-I complex UEV domain-containing protein | ESCRT-I complex UEV domain-containing protein | ESCRT-I_UEV_domain | 9 |
IPR052071 | 52,071 | Signal peptide, CUB and EGF-like domain-containing protein | SCUB_EGF-like_domain | Family | 6,270 | true | false | This family of proteins includes coreceptors and regulators of signaling pathways essential for developmental processes such as chondrogenesis, osteogenesis, and angiogenesis. Members of this family facilitate the interaction of ligands with their respective receptors, enhancing signaling cascades. They are involved in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24046"
] | [
"SCUB_EGF-like_domain"
] | [
6270
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5362798",
"R-HSA-1474228",
"R-HSA-5362798",
"R-MMU-1474228",
"R-MMU-5362798"
] | [
"REACTOME:R-DRE-5362798",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-5362798",
"REACTOME:R-MMU-1474228",
"REACTOME:R-MMU-5362798"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6270
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
17,
9,
14
] | 5 | true | Family | Signal peptide, CUB and EGF-like domain-containing protein | Signal peptide, CUB and EGF-like domain-containing protein | SCUB_EGF-like_domain | 4 |
IPR052072 | 52,072 | Vascular development regulator domain-containing protein | Vascular_dev_regulator | Family | 7,012 | true | false | This family of proteins includes members that are involved in the regulation of GTPase signaling pathways, particularly in the context of vascular development and endothelial cell function. They play a crucial role in the formation of vascular structures through vasculogenesis and angiogenesis. These proteins modulate ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16027"
] | [
"Vascular_dev_regulator"
] | [
7012
] | 1 | [] | [] | [] | 0 | [
"2f6h",
"3ec8",
"3mmi",
"3wb8",
"4j5l",
"4j5m",
"4kp3",
"4l8t",
"4ll6",
"4ll8",
"4lli",
"4lnz",
"4lwz",
"4lx0",
"4lx1",
"4lx2",
"5jcy",
"5jcz",
"5kho",
"5khq",
"6eyw",
"6ixo",
"6ixp",
"6ixq",
"6ixr",
"6ku0",
"7kfl"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7012
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
20,
8,
27,
20,
13,
1,
15,
16,
1,
1,
58
] | 11 | true | Family | Vascular development regulator domain-containing protein | Vascular development regulator domain-containing protein | Vascular_dev_regulator | 4 |
IPR052073 | 52,073 | Amide and Lactam Catabolism Regulators | Amide_Lactam_Regulators | Family | 6,546 | true | false | This family of proteins includes transcription factors that regulate the expression of genes involved in the catabolism of amides, omega amino acids, and lactams. Some members are also implicated in the biosynthesis and detoxification of fusaric acid and its derivatives, which are mycotoxins with phytotoxic properties.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47171"
] | [
"Amide_Lactam_Regulators"
] | [
6546
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
6546
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Amide and Lactam Catabolism Regulators | Amide and Lactam Catabolism Regulators | Amide_Lactam_Regulators | 6 |
IPR052074 | 52,074 | Non-receptor Tyrosine-protein Phosphatases | NonRcpt_TyrProt_Phosphatase | Family | 6,233 | true | false | The protein family includes tyrosine-protein phosphatases that are non-receptor types and are involved in various cellular processes. Members of the family are targeted to sites of actin polymerization in response to extracellular stimuli and exhibit tyrosine phosphatase activity towards tyrosyl phosphorylated substrat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46900"
] | [
"NonRcpt_TyrProt_Phosphatase"
] | [
6233
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.48",
"R-HSA-1660499",
"R-HSA-9008059",
"R-HSA-9696264",
"R-HSA-9696270",
"R-HSA-9696273",
"R-MMU-1660499",
"R-MMU-9696264",
"R-MMU-9696270",
"R-MMU-9696273"
] | [
"EC:3.1.3.48",
"REACTOME:R-HSA-1660499",
"REACTOME:R-HSA-9008059",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-1660499",
"REACTOME:R-MMU-9696264",
"REACTOME:R-MMU-9696270",
"REACTOME:R-MMU-9696273"
] | 10 | [
"1b8q",
"1d5g",
"1gm1",
"1ozi",
"1q7x",
"1qau",
"1qav",
"1vj6",
"1wch",
"2m0z",
"2m10",
"3lnx",
"3lny",
"3pdz",
"4hop",
"5glj",
"5zds",
"6gbd",
"6gbe",
"7qcx",
"7qcy",
"7xty"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6233
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
36,
16,
13,
11
] | 5 | true | Family | Non-receptor Tyrosine-protein Phosphatases | Non-receptor Tyrosine-protein Phosphatases | NonRcpt_TyrProt_Phosphatase | 4 |
IPR052075 | 52,075 | Heme exporter protein D | Heme_exporter_D | Family | 3,976 | true | false | This family of proteins is involved in the transport of heme, an essential cofactor for various biological processes. Members of this family are responsible for exporting heme to the periplasmic space in bacterial cells, where it is utilized for the assembly of c-type cytochromes. These cytochromes play a crucial role ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37531"
] | [
"Heme_exporter_D"
] | [
3976
] | 1 | [] | [] | [] | 0 | [
"7f02",
"7f03",
"7f04",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
3936,
40
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Heme exporter protein D | Heme exporter protein D | Heme_exporter_D | 9 |
IPR052076 | 52,076 | Transient receptor potential cation channel | TRP_cation_channel | Family | 6,283 | true | false | This family of proteins includes receptor-activated non-selective cation channels that play a central role in the detection of pain, temperature, and other sensations. They are involved in various physiological processes such as pain response to inflammatory mediators, cold perception, oxygen concentration perception, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47143"
] | [
"TRP_cation_channel"
] | [
6283
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-3295583",
"R-HSA-3295583",
"R-MMU-3295583",
"R-RNO-3295583"
] | [
"REACTOME:R-DME-3295583",
"REACTOME:R-HSA-3295583",
"REACTOME:R-MMU-3295583",
"REACTOME:R-RNO-3295583"
] | 4 | [
"3j9p",
"6pqo",
"6pqp",
"6pqq",
"6v9v",
"6v9w",
"6v9x",
"6v9y",
"6wj5",
"6x2j",
"7jup",
"7or0",
"7or1",
"7ykr",
"7yks",
"9m8n",
"9m8s",
"9moe"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Avipoxvirus",
"Bacteria",
"Eukaryota"
] | [
3,
12,
6268
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
14,
14,
2,
2,
3
] | 6 | true | Family | Transient receptor potential cation channel | Transient receptor potential cation channel | TRP_cation_channel | 6 |
IPR052077 | 52,077 | Cell Cycle Regulator and Phase Variation Mediator | CcrZ_PhaseVar_Mediator | Family | 4,267 | true | false | The protein family is involved in cell cycle regulation and chromosome integrity. Members of the family activate DnaA-dependent chromosomal DNA replication initiation, ensuring timely replication during the cell cycle. They may regulate replication initiation through phosphorylation of potential second messengers or me... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40086"
] | [
"CcrZ_PhaseVar_Mediator"
] | [
4267
] | 1 | [] | [] | [] | 0 | [
"3i0o",
"3i0q",
"3i1a",
"3q2m",
"4r77",
"4r78",
"4r7b",
"7s3l"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Promethearchaeum syntrophicum",
"metagenomes"
] | [
4232,
13,
2,
20
] | 4 | [] | [] | 0 | true | Family | Cell Cycle Regulator and Phase Variation Mediator | Cell Cycle Regulator and Phase Variation Mediator | CcrZ_PhaseVar_Mediator | 1 |
IPR052078 | 52,078 | Trehalose Metabolism Glycosyltransferase | Trehalose_Metab_GTase | Family | 2,857 | true | false | This family of proteins includes enzymes involved in the metabolism of trehalose, a disaccharide sugar. Members of this family are capable of synthesizing trehalose through a reversible reaction, predominantly from ADP-glucose and glucose, although some can also use UDP-glucose or GDP-glucose. The equilibrium of this r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47779"
] | [
"Trehalose_Metab_GTase"
] | [
2857
] | 1 | [
"EC"
] | [
"2.4.1"
] | [
"EC:2.4.1"
] | 1 | [
"2x6q",
"2x6r",
"2xa1",
"2xa2",
"2xa9",
"2xmp",
"6zj4",
"6zj7",
"6zjh",
"6zmz",
"6zn1"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
245,
786,
1721,
105
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Trehalose Metabolism Glycosyltransferase | Trehalose Metabolism Glycosyltransferase | Trehalose_Metab_GTase | 9 |
IPR052079 | 52,079 | E3 ubiquitin-ligases/Copine domain-containing protein | E3_ligase/Copine_domain | Family | 6,429 | true | false | This family of proteins includes E3 ubiquitin-protein ligases and copine domain-containing proteins. The E3 ubiquitin-protein ligases are involved in various cellular processes, including the modulation of hormone signaling pathways such as jasmonate and abscisic acid, which are crucial for plant responses to stress an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45751"
] | [
"E3_ligase/Copine_domain"
] | [
6429
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [
"6k82",
"6k83",
"6k85",
"6k86",
"6k87",
"6k88",
"6k89",
"6k8a",
"6k8b",
"8hmg",
"8hmh",
"8xt5"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Megaviricetes",
"marine sediment metagenome"
] | [
6420,
8,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
31,
2,
25,
72
] | 4 | true | Family | E3 ubiquitin-ligases/Copine domain-containing protein | E3 ubiquitin-ligases/Copine domain-containing protein | E3_ligase/Copine_domain | 2 |
IPR052080 | 52,080 | von Willebrand factor C/EGF & Fibrillin | vWF_C/EGF_Fibrillin | Family | 9,759 | true | false | The von Willebrand factor C and EGF domain-containing protein family includes regulatory elements in signaling pathways, structural components of the extracellular matrix, and regulators of growth factor bioavailability. Members of this family are involved in the beta-catenin signaling pathway and may play a role in th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47333"
] | [
"vWF_C/EGF_Fibrillin"
] | [
9759
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1474228",
"R-BTA-1566948",
"R-BTA-2129379",
"R-BTA-216083",
"R-BTA-2173789",
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-1474228",
"R-HSA-1566948",
"R-HSA-2129379",
"R-HSA-216083",
"R-HSA-2173789",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-1474228",
"R-MMU-1566948",
"R-MMU-2129379",... | [
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-1566948",
"REACTOME:R-BTA-2129379",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-1566948",
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-216083",
"REACTOME:R... | 25 | [
"1emn",
"1emo",
"1uzj",
"1uzk",
"1uzp",
"1uzq",
"2w86"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Kangiella spongicola",
"bird metagenome"
] | [
9757,
1,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
30,
39,
28,
31
] | 5 | true | Family | von Willebrand factor C/EGF & Fibrillin | von Willebrand factor C/EGF & Fibrillin | vWF_C/EGF_Fibrillin | 4 |
IPR052081 | 52,081 | Dispatched hedgehog regulator | Dispatched_Hh_regulator | Family | 4,981 | true | false | This family of proteins is involved in the hedgehog (Hh) signaling pathway. Members of this family play a crucial role in regulating the release and extracellular accumulation of cholesterol-modified hedgehog proteins, which is essential for the effective production of the Hh signal. Some family members have been shown... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45951"
] | [
"Dispatched_Hh_regulator"
] | [
4981
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-209471",
"R-DRE-5362798",
"R-HSA-5362798",
"R-MMU-5362798"
] | [
"REACTOME:R-DME-209471",
"REACTOME:R-DRE-5362798",
"REACTOME:R-HSA-5362798",
"REACTOME:R-MMU-5362798"
] | 4 | [
"6tbu",
"6td6",
"6xe6",
"7e2g",
"7e2h",
"7e2i",
"7fif",
"7rph",
"7rpi",
"7rpj",
"7rpk"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
4980,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
1,
5,
5,
11
] | 6 | true | Family | Dispatched hedgehog regulator | Dispatched hedgehog regulator | Dispatched_Hh_regulator | 3 |
IPR052082 | 52,082 | Peripheral myelin sheath structural protein | Myelin_sheath_structural | Family | 4,925 | true | false | This family of proteins includes scaffolding components that are essential for the structural integrity and function of myelinated nerves. They play a crucial role in the maintenance of the peripheral myelin sheath, which is crucial for efficient nerve impulse transmission and sensory perception. These proteins are inv... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23348"
] | [
"Myelin_sheath_structural"
] | [
4925
] | 1 | [
"REACTOME"
] | [
"R-HSA-9619665"
] | [
"REACTOME:R-HSA-9619665"
] | 1 | [
"4cmz",
"4cn0"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanolobus vulcani",
"Trachysalambria curvirostris majanivirus",
"bird metagenome"
] | [
23,
4899,
1,
1,
1
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
19,
24,
26
] | 5 | true | Family | Peripheral myelin sheath structural protein | Peripheral myelin sheath structural protein | Myelin_sheath_structural | 9 |
IPR052083 | 52,083 | Aminoacylase-1 peptidase M20A | Aminoacylase-1_M20A | Family | 5,438 | true | false | The Aminoacylase-1 family is characterized by its enzymatic function in catalyzing the hydrolysis of N-acetylated amino acids, resulting in the release of acetate and free amino acids. This reaction is a key step in the metabolism of acetylated amino acids, which are not only intermediates in the degradation of protein... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45892"
] | [
"Aminoacylase-1_M20A"
] | [
5438
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1.14",
"R-DDI-5423646",
"R-DDI-9753281",
"R-HSA-5423646",
"R-HSA-5579007",
"R-HSA-9753281",
"R-MMU-5423646",
"R-MMU-9753281",
"R-RNO-5423646",
"R-RNO-9753281",
"R-SSC-5423646",
"R-SSC-9753281"
] | [
"EC:3.5.1.14",
"REACTOME:R-DDI-5423646",
"REACTOME:R-DDI-9753281",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-5579007",
"REACTOME:R-HSA-9753281",
"REACTOME:R-MMU-5423646",
"REACTOME:R-MMU-9753281",
"REACTOME:R-RNO-5423646",
"REACTOME:R-RNO-9753281",
"REACTOME:R-SSC-5423646",
"REACTOME:R-SSC-975... | 12 | [
"1q7l"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Musca hytrovirus(isolate Musca domestica/United States/Boucias/-)",
"marine sediment metagenome"
] | [
5,
5431,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
19,
5,
4,
10,
13,
9,
6,
12,
13
] | 9 | true | Family | Aminoacylase-1 peptidase M20A | Aminoacylase-1 peptidase M20A | Aminoacylase-1_M20A | 1 |
IPR052084 | 52,084 | Spliceosome-associated SF3B4 subunit | SF3B4_spliceosome_assoc | Family | 4,767 | true | false | This family of proteins is involved in the splicing of pre-mRNAs, a critical step in gene expression. Members of this family are components of the spliceosome, particularly the 17S U2 small nuclear ribonucleoprotein (snRNP) complex. They play a role in early spliceosome assembly and in recognizing the intron branch sit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48030"
] | [
"SF3B4_spliceosome_assoc"
] | [
4767
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72165",
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165",
"R-RNO-72163",
"R-RNO-72165"
] | [
"REACTOME:R-CEL-72165",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165",
"REACTOME:R-RNO-72163",
"REACTOME:R-RNO-72165"
] | 7 | [
"1x5t",
"5gm6",
"5gvq",
"5lsb",
"5nrl",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6g90",
"6qx9",
"6y53",
"6y5q",
"7abg",
"7abh",
"7abi",
"7dco",
"7dvq",
"7evo",
"7onb",
"7oqb",
"7oqe",
"7qtt",
"7vpx",
"8ch6",
"8h6e",
"8h6j",
"8h6k",
"8h6l"... | 48 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4767
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
1,
2,
5,
1,
1,
4,
5,
1,
1,
10
] | 12 | true | Family | Spliceosome-associated SF3B4 subunit | Spliceosome-associated SF3B4 subunit | SF3B4_spliceosome_assoc | 2 |
IPR052085 | 52,085 | WD repeat, SAM and U-box domain-containing | WD-SAM-U-box | Family | 4,665 | true | false | The WD repeat, SAM and U-box domain-containing protein family is characterized by the presence of WD repeats, SAM, and U-box domains. Members of this family are involved in protein-protein interactions and cellular processes. The U-box domain suggests that these proteins may function as E3 ubiquitin ligases, which play... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46573"
] | [
"WD-SAM-U-box"
] | [
4665
] | 1 | [] | [] | [] | 0 | [
"4wz0"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nucleocytoviricota",
"Pseudomonadati",
"metagenomes"
] | [
4584,
22,
29,
30
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus"
] | [
7,
4,
2,
5,
2,
7
] | 6 | true | Family | WD repeat, SAM and U-box domain-containing | WD repeat, SAM and U-box domain-containing | WD-SAM-U-box | 3 |
IPR052086 | 52,086 | Mannan Polymerase Complex Subunit | Mannan_Polymerase_Subunit | Family | 4,510 | true | false | This family of proteins is involved in the biosynthesis of the mannan backbone of N-linked glycans, which are essential components of cell wall and periplasmic proteins. Members of this family exhibit alpha-1,6-mannosyltransferase activity, playing a crucial role in the elongation process of the mannan chains. Some pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43083"
] | [
"Mannan_Polymerase_Subunit"
] | [
4510
] | 1 | [] | [] | [] | 0 | [
"3zf8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
59,
4447,
4
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
2
] | 3 | true | Family | Mannan Polymerase Complex Subunit | Mannan Polymerase Complex Subunit | Mannan_Polymerase_Subunit | 3 |
IPR052087 | 52,087 | Ribosomal RNA-processing protein RRP12 | RRP12 | Family | 4,531 | false | false | Ribosomal RNA-processing protein 12 (RRP12) proteins are members of pre-ribosome-associated HEAT repeats-containing proteins [ , , ]. They are involved in the maturation and nuclear export of both pre-40S and pre-60S ribosomal subunits. They are required for the processing of RNA components within pre-ribosomes, which ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48287"
] | [
""
] | [
4531
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SPO-6798695",
"R-SPO-8951664",
"R-SPO-917937"
] | [
"REACTOME:R-SPO-6798695",
"REACTOME:R-SPO-8951664",
"REACTOME:R-SPO-917937"
] | 3 | [
"7wts",
"7wtt",
"7wtu",
"7wtv",
"7wtw",
"7wtx",
"7wtz",
"7wu0"
] | 8 | [
"PUB00016366",
"PUB00101821",
"PUB00101822"
] | [
"15112237",
"14729571",
"29875412"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.",
"Visualizing late states of human 40S ribosomal subunit maturation."
] | [
2004,
2004,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Shewanella electrica",
"uncultured organism MedDCM-OCT-S08-C998"
] | [
4529,
1,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
4,
6,
2,
1,
4,
1,
2
] | 9 | true | Family | Ribosomal RNA-processing protein RRP12 | Ribosomal RNA-processing protein RRP12 | RRP12 | 1 |
IPR052088 | 52,088 | E3 ubiquitin-protein ligase SINA | E3_ubiquitin-ligase_SINA | Family | 5,149 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that are involved in the ubiquitination and subsequent proteasomal degradation of various target proteins. They contain a RING-type zinc finger domain crucial for their ligase activity and a substrate-binding domain (SBD) that mediates homodimerization and i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10315"
] | [
"E3_ubiquitin-ligase_SINA"
] | [
5149
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
5143,
5,
1
] | 3 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
1,
44,
36
] | 4 | true | Family | E3 ubiquitin-protein ligase SINA | E3 ubiquitin-protein ligase SINA | E3_ubiquitin-ligase_SINA | 4 |
IPR052089 | 52,089 | Ankyrin repeat and BTB/POZ domain-containing protein | Ankyrin-BTB/POZ_domain | Family | 4,554 | true | true | The Ankyrin repeat and BTB/POZ domain-containing protein family is characterised by the presence of ankyrin repeats and a BTB/POZ domain. These proteins may play a role in cellular processes such as the initiation of hepatocyte growth, as suggested by some members of the family. The ankyrin repeats are known for mediat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46071"
] | [
"Ankyrin-BTB/POZ_domain"
] | [
4554
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4554
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
3,
8,
9,
11
] | 5 | true | Family | Ankyrin repeat and BTB/POZ domain-containing protein | Ankyrin repeat and BTB/POZ domain-containing protein | Ankyrin-BTB/POZ_domain | 1 |
IPR052090 | 52,090 | Cytolytic pore-forming toxin | Cytolytic_pore-forming_toxin | Family | 4,855 | true | false | This family of proteins includes toxins that exhibit a range of biological activities, primarily associated with cytolytic functions. They are capable of forming pores in cell membranes, leading to hemolytic activity. These proteins are known to interact with erythrocytes, inducing potent hemolysis and displaying cardi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31594"
] | [
"Cytolytic_pore-forming_toxin"
] | [
4855
] | 1 | [] | [] | [] | 0 | [
"4wvm"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4855
] | 1 | [
"Danio rerio",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
81,
1
] | 2 | true | Family | Cytolytic pore-forming toxin | Cytolytic pore-forming toxin | Cytolytic_pore-forming_toxin | 9 |
IPR052091 | 52,091 | Beta-alanine Activation and Resistance | Beta-ala_Activ/Resist | Family | 4,053 | true | false | The Beta-alanine-activating enzyme family is involved in the ATP-dependent activation of beta-alanine, a process that forms a thioester bond with the enzyme's phosphopantetheine group. The activated beta-alanine is then transferred to an unknown acceptor, which may be part of a post-translational protein modification o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44394"
] | [
"Beta-ala_Activ/Resist"
] | [
4053
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.2.1.-",
"PWY-301",
"PWY-5045",
"PWY-5136",
"PWY-5660",
"PWY-5752",
"PWY-5922",
"PWY-5923",
"PWY-5924",
"PWY-5927",
"PWY-5958",
"PWY-6457",
"PWY-6593",
"PWY-6670",
"PWY-6722",
"PWY-6799",
"PWY-6926",
"PWY-6948",
"PWY-7007",
"PWY-7288",
"PWY-735",
"PWY-7462",
"PWY-7536",... | [
"EC:6.2.1.-",
"METACYC:PWY-301",
"METACYC:PWY-5045",
"METACYC:PWY-5136",
"METACYC:PWY-5660",
"METACYC:PWY-5752",
"METACYC:PWY-5922",
"METACYC:PWY-5923",
"METACYC:PWY-5924",
"METACYC:PWY-5927",
"METACYC:PWY-5958",
"METACYC:PWY-6457",
"METACYC:PWY-6593",
"METACYC:PWY-6670",
"METACYC:PWY-67... | 53 | [
"6tjc",
"6tjf",
"8pr9",
"8pra",
"8prb",
"8prc",
"8prd",
"8pre",
"8prf",
"8prg",
"8prh",
"8pri",
"8prj",
"8prl",
"8prm",
"8pro",
"8prp",
"8prq",
"8prr",
"8prs",
"8prt"
] | 21 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
46,
559,
3412,
36
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
3,
2,
3,
8,
5,
3,
3,
29
] | 9 | true | Family | Beta-alanine Activation and Resistance | Beta-alanine Activation and Resistance | Beta-ala_Activ/Resist | 2 |
IPR052092 | 52,092 | Splicing Factor 3A Subunit 2 | SF3A2 | Family | 4,449 | true | false | The SF3A2 family is involved in the critical process of pre-mRNA splicing, which is essential for the removal of introns from transcribed pre-mRNAs. Members of the SF3A2 family are components of the 17S U2 SnRNP complex within the spliceosome. They play a pivotal role in early spliceosome assembly and in recognizing th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23205"
] | [
"SF3A2"
] | [
4449
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 4 | [
"4dgw",
"5gm6",
"5nrl",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ff4",
"6ff7",
"6g90",
"6qx9",
"6y53",
"6y5q",
"7abg",
"7abh",
"7abi",
"7dco",
"7evo",
"7onb",
"7oqb",
"7oqe",
"7q4o",
"7q4p",
"7qtt",
"7vpx",
"8ch6",
"8h6e",
"8h6j",
"8h6k"... | 46 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4449
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
3,
5,
1,
3,
4,
1,
1,
8
] | 12 | true | Family | Splicing Factor 3A Subunit 2 | Splicing Factor 3A Subunit 2 | SF3A2 | 8 |
IPR052093 | 52,093 | Homologous Recombination Repair Mediator | HR_Repair_Mediator | Family | 4,434 | true | false | This family of proteins is involved in the homologous recombination (HR) pathway of DNA repair, specifically in the repair of double-stranded DNA breaks that may arise during DNA replication or as a result of DNA-damaging agents. Members of this family participate in the formation of RAD51 foci in response to DNA damag... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46239"
] | [
"HR_Repair_Mediator"
] | [
4434
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693616",
"R-HSA-912446",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709603",
"R-HSA-983231",
"R-MMU-5685942",
"R-MMU-5693568",
"R-MMU-5693579",
"R-MMU-5693616",
"R-MMU-983231"
] | [
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-912446",
"REACTOME:R-HSA-9701192",
"REACTOME:R-HSA-9704331",
"REACTOME:R-HSA-9704646",
"REACTOME:R-HSA-9709603",
"REACTOME:R-HSA-983231",
"REACTOME:... | 16 | [
"8faz",
"8gbj",
"8gj8",
"8gja",
"8ouy",
"8ouz",
"9svy",
"9sw0"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Marine Group III euryarchaeote CG-Bathy1"
] | [
4433,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
2,
20,
12,
3,
1,
6,
5,
1,
1,
11
] | 11 | true | Family | Homologous Recombination Repair Mediator | Homologous Recombination Repair Mediator | HR_Repair_Mediator | 9 |
IPR052094 | 52,094 | Pre-mRNA-splicing and ERAD-associated protein | Pre-mRNA-splicing_ERAD | Family | 4,270 | true | false | This family of proteins includes members that are involved in pre-mRNA splicing, a fundamental process in gene expression where introns are removed and exons are joined to form a mature mRNA transcript. Some members of this family are also implicated in the endoplasmic reticulum-associated protein degradation pathway (... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44313"
] | [
"Pre-mRNA-splicing_ERAD"
] | [
4270
] | 1 | [] | [] | [] | 0 | [
"2d9o",
"5y88"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
100,
3,
4137,
21,
9
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
3,
1,
4,
1,
1,
11,
1,
1
] | 9 | true | Family | Pre-mRNA-splicing and ERAD-associated protein | Pre-mRNA-splicing and ERAD-associated protein | Pre-mRNA-splicing_ERAD | 8 |
IPR052095 | 52,095 | UNC-13 domain-containing protein | UNC-13_domain | Family | 4,412 | true | false | This family of proteins is involved in various intracellular trafficking processes, including endosome to Golgi retrograde transport, and the regulation of secretory lysosome exocytosis. Members of this family play a crucial role in cytotoxic granule exocytosis in lymphocytes, which is essential for immune response. Th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45999"
] | [
"UNC-13_domain"
] | [
4412
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 4 | [
"9la9"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4412
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
22,
3,
28,
12,
10
] | 6 | true | Family | UNC-13 domain-containing protein | UNC-13 domain-containing protein | UNC-13_domain | 8 |
IPR052097 | 52,097 | SET and MYND domain-containing protein | SET-MYND_domain_protein | Family | 4,610 | true | false | This family of proteins includes SET and MYND domain-containing proteins that are implicated in epigenetic regulation. Members of this family are characterized by their dual activities as methyltransferases and as negative regulators of HDAC1. They play a crucial role in cardiac development by regulating gene expressio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46165"
] | [
"SET-MYND_domain_protein"
] | [
4610
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 146 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Lokiarchaeum ossiferum",
"Eukaryota",
"Pseudomonadati",
"viral metagenome"
] | [
1,
4602,
6,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
4,
16,
4,
1,
1,
3
] | 7 | true | Family | SET and MYND domain-containing protein | SET and MYND domain-containing protein | SET-MYND_domain_protein | 1 |
IPR052098 | 52,098 | Presynaptic Scaffold Protein Bassoon/Piccolo | Presynaptic_Scaffold_Bsn/Pclo | Family | 4,141 | true | false | The protein family functions as scaffold proteins at the presynaptic cytomatrix of the active zone (CAZ), a key site for neurotransmitter release. They are involved in the formation of Piccolo-Bassoon transport vesicles (PTVs), which are essential for synaptic contact development. At the CAZ, they organize synaptic ves... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14113"
] | [
"Presynaptic_Scaffold_Bsn/Pclo"
] | [
4141
] | 1 | [
"REACTOME"
] | [
"R-HSA-9662360"
] | [
"REACTOME:R-HSA-9662360"
] | 1 | [
"1rh8",
"1ujd",
"8i3e"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4140,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
37,
10,
5,
9
] | 4 | true | Family | Presynaptic Scaffold Protein Bassoon/Piccolo | Presynaptic Scaffold Protein Bassoon/Piccolo | Presynaptic_Scaffold_Bsn/Pclo | 7 |
IPR052099 | 52,099 | Diverse Regulatory Transcription Factors | Regulatory_TF_Diverse | Family | 4,452 | true | false | The protein family encompasses transcription factors that regulate various biological processes, including carbohydrate metabolism, sterol synthesis, filamentous growth, and virulence in response to environmental cues such as oxygen levels and nutrient availability. Members of the family are involved in the activation ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47336"
] | [
"Regulatory_TF_Diverse"
] | [
4452
] | 1 | [] | [] | [] | 0 | [
"5gpd",
"5grs",
"7f2f",
"8hov"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces polyasparticus"
] | [
4451,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
2,
2,
1
] | 4 | true | Family | Diverse Regulatory Transcription Factors | Diverse Regulatory Transcription Factors | Regulatory_TF_Diverse | 7 |
IPR052100 | 52,100 | NADPH-dependent quinone oxidoreductase VAT1 | VAT1 | Family | 3,469 | true | true | This entry includes NADPH-dependent quinone oxidoreductase VAT1 and related proteins. Members of this family exhibit ATPase activity and are involved in cellular processes such as calcium-regulated keratinocyte activation during epidermal repair mechanisms. They do not influence cell proliferation but are implicated in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44054"
] | [
"SV-ATPase_mito-regulator"
] | [
3469
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.6.5.5",
"R-DRE-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"EC:1.6.5.5",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 5 | [
"4a27",
"6k9y",
"6lhr",
"6lii"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"ecological metagenomes"
] | [
467,
2963,
22,
17
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
11,
8,
4
] | 5 | true | Family | NADPH-dependent quinone oxidoreductase VAT1 | NADPH-dependent quinone oxidoreductase VAT1 | VAT1 | 2 |
IPR052101 | 52,101 | Protein CYTOSOLIC ABA RECEPTOR KINASE-like | CARK-like | Family | 5,050 | true | true | The protein family in question is characterized by its members' involvement in various signaling pathways related to plant stress responses and growth regulation. Members of the family function as kinases, with some acting as serine-threonine kinases and others as tyrosine kinases. They play roles in hypersensitive res... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47983"
] | [
"Plant_StressResp_Kinase"
] | [
5050
] | 1 | [] | [] | [] | 0 | [
"5xd6"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5050
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
46,
31,
90
] | 3 | true | Family | Protein CYTOSOLIC ABA RECEPTOR KINASE-like | Protein CYTOSOLIC ABA RECEPTOR KINASE-like | CARK-like | 4 |
IPR052102 | 52,102 | Enkurin domain-containing protein | Enkurin_domain-protein | Family | 3,802 | true | false | This family of proteins includes microtubule-binding proteins that play a role in the organization and stability of microtubules. They are involved in the localization of calcium-sensitive signal transduction machinery in sperm and are essential for the beating of motile cilia by being part of the dynein-decorated doub... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21490"
] | [
"Enkurin_domain-protein"
] | [
3802
] | 1 | [] | [] | [] | 0 | [
"6u42",
"6ve7",
"7rro",
"7ung",
"8g2z",
"8g3d",
"8glv",
"8i7o",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8sf7",
"8snb",
"8to0",
"9cpb",
"9cpc",
"9d5n",
"9e2g",
"9e5c",
"9e78",
"9fqr"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3802
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
7,
4,
5
] | 5 | true | Family | Enkurin domain-containing protein | Enkurin domain-containing protein | Enkurin_domain-protein | 9 |
IPR052103 | 52,103 | Dual Specificity Protein Phosphatases | Dual_spec_Phospatases | Family | 3,540 | true | false | The Dual Specificity Protein Phosphatase family is involved in the regulation of key signaling pathways through the dephosphorylation of MAP kinases such as ERK, JNK, and p38, which are critical for various cellular responses. Members of the family negatively regulate TCR signaling by inactivating the MAP3K7 adapter TA... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45961"
] | [
"Dual_spec_Phospatases"
] | [
3540
] | 1 | [
"EC",
"EC"
] | [
"3.1.3",
"3.1.3.48"
] | [
"EC:3.1.3",
"EC:3.1.3.48"
] | 2 | [
"2hcm",
"2q05",
"2wgp",
"5y15",
"5y16",
"6i28"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
55,
23,
3363,
88,
11
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
13,
1,
4,
6,
6
] | 6 | true | Family | Dual Specificity Protein Phosphatases | Dual Specificity Protein Phosphatases | Dual_spec_Phospatases | 6 |
IPR052104 | 52,104 | Mitochondrial Release Factor mL62 | Mito_Release_Factor_mL62 | Family | 3,402 | true | false | The protein family is characterized by its role as peptidyl-tRNA hydrolases within the mitochondrial large ribosomal subunit. Members act as codon-independent translation release factors that have lost stop codon specificity, which may direct the termination of translation in the mitochondrion, particularly during abor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11075"
] | [
"Mito_Release_Factor_mL62"
] | [
3402
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.29",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"EC:3.1.1.29",
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 11 | [
"1j26",
"3j7y",
"3j9m",
"4ce4",
"4v1a",
"5aj4",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5h",
"7a5i",
"7a5j",
"7a5k"... | 92 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
86,
3314,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
7,
2,
2,
1,
3,
1,
1
] | 9 | true | Family | Mitochondrial Release Factor mL62 | Mitochondrial Release Factor mL62 | Mito_Release_Factor_mL62 | 9 |
IPR052105 | 52,105 | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase | MGAT5_Glycosyltransferase | Family | 3,452 | true | false | This family of proteins includes glycosyltransferases involved in the modification of glycoproteins by catalyzing the addition of N-acetylglucosamine (GlcNAc) to mannose residues in N-linked oligosaccharides. These enzymes play a crucial role in the biosynthesis of branched, complex-type N-glycans, which are essential ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15075"
] | [
"MGAT5_Glycosyltransferase"
] | [
3452
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1.155",
"PWY-7426",
"R-CEL-8932504",
"R-CEL-975577",
"R-HSA-8932504",
"R-HSA-9694548",
"R-HSA-975577",
"R-MMU-8932504",
"R-MMU-975577",
"R-RNO-975577"
] | [
"EC:2.4.1.155",
"METACYC:PWY-7426",
"REACTOME:R-CEL-8932504",
"REACTOME:R-CEL-975577",
"REACTOME:R-HSA-8932504",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-975577",
"REACTOME:R-MMU-8932504",
"REACTOME:R-MMU-975577",
"REACTOME:R-RNO-975577"
] | 10 | [
"5zib",
"5zic",
"6yjq",
"6yjr",
"6yjs",
"6yjt",
"6yju",
"6yjv",
"8ce3",
"9f5h"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3452
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
6,
4,
10
] | 5 | true | Family | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase | MGAT5_Glycosyltransferase | 4 |
IPR052107 | 52,107 | HEAT Repeat-containing Protein 6 | HEAT6 | Family | 3,491 | true | false | The HEAT repeat-containing protein 6 family is characterized by the presence of HEAT repeats, which are tandemly repeated units typically involved in intracellular transport processes and protein-protein interactions. Members of this family are found across various species, indicating a conserved functional role. The h... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13366"
] | [
"HEAT6"
] | [
3491
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3491
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
16,
1,
3,
9,
1,
3,
3,
6
] | 8 | true | Family | HEAT Repeat-containing Protein 6 | HEAT Repeat-containing Protein 6 | HEAT6 | 7 |
IPR052108 | 52,108 | Multiple EGF-like domains/Integrin beta-like | MEGF/SIB | Family | 2,840 | true | false | The MEGF/SIB family is involved in various cellular functions, including cellular adhesion, phagocytosis, and neuron spacing in the retina. Members of the family act as membrane receptors for the engulfment of apoptotic cells, interacting with signals like C1q and phosphatidylserine. They are implicated in the formatio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24035"
] | [
"MEGF/SIB"
] | [
2840
] | 1 | [] | [] | [] | 0 | [
"2gy5",
"2gy7",
"4k0v",
"5xau",
"7cec"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaentomopoxvirus acuprea",
"Eukaryota"
] | [
1,
2839
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
13,
3,
5,
3,
1
] | 6 | true | Family | Multiple EGF-like domains/Integrin beta-like | Multiple EGF-like domains/Integrin beta-like | MEGF/SIB | 2 |
IPR052109 | 52,109 | Serine/Arginine Repetitive Matrix Domain-Containing Protein | SRRM_Domain-Containing | Family | 3,400 | true | false | This family of proteins includes splicing factors that are involved in pre-mRNA processing and neural cell differentiation. Members of this family are known to regulate alternative splicing events, which are critical for the expression of neural-specific isoforms and the proper functioning of the nervous system. Some p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34755"
] | [
"SRRM_Domain-Containing"
] | [
3400
] | 1 | [
"REACTOME"
] | [
"R-MMU-72163"
] | [
"REACTOME:R-MMU-72163"
] | 1 | [
"6hiv"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Marsarchaeota G2 archaeon OSP_D",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
77,
1,
3308,
7,
7
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
28,
13,
13,
1,
22
] | 5 | true | Family | Serine/Arginine Repetitive Matrix Domain-Containing Protein | Serine/Arginine Repetitive Matrix Domain-Containing Protein | SRRM_Domain-Containing | 5 |
IPR052110 | 52,110 | Multiple coagulation factor deficiency protein 2-like | MCFD2-like | Family | 3,347 | true | true | The protein family is involved in various cellular processes, including the ER-to-Golgi transport of selected proteins and cell-cell adhesion. Members of the family, mainly from animals, form a specific cargo receptor complex, known as the MCFD2-LMAN1 complex, which is essential for the secretion of coagulation factors... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23104"
] | [
"ER-Golgi_Adhesion_Reg"
] | [
3347
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-204005",
"R-HSA-5694530",
"R-HSA-948021",
"R-MMU-204005",
"R-MMU-5694530",
"R-RNO-204005",
"R-RNO-5694530"
] | [
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA-948021",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU-5694530",
"REACTOME:R-RNO-204005",
"REACTOME:R-RNO-5694530"
] | 7 | [
"2vrg",
"3a4u",
"3lcp",
"3wht",
"3whu",
"3wnx",
"4ygb",
"4ygc",
"4ygd",
"4yge",
"8jp4",
"8jp5",
"8jp6",
"8jp7",
"8jp8",
"8jp9",
"8jpg"
] | 17 | [
"PUB00090575",
"PUB00154551",
"PUB00154552",
"PUB00160386"
] | [
"19473726",
"12717434",
"29507355",
"21423674"
] | [
"Cgr11 encodes a secretory protein involved in cell adhesion.",
"Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.",
"Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.",
"Longistatin, a plasminogen ac... | [
2009,
2003,
2018,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3347
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
6,
8,
8,
11
] | 6 | true | Family | Multiple coagulation factor deficiency protein 2-like | Multiple coagulation factor deficiency protein 2-like | MCFD2-like | 4 |
IPR052111 | 52,111 | Spermatogenesis and Ciliary Microtubule-associated Protein | Spermatogenesis_Ciliary_MAP | Family | 3,169 | true | false | This family of proteins is associated with spermatogenesis and ciliary function. Members are involved in apoptosis regulation and microtubule dynamics. They play a role in microtubule stabilization, bundling, and protection against depolymerization, which is crucial for cell migration, ciliary structure integrity, and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12509"
] | [
"Spermatogenesis_Ciliary_MAP"
] | [
3169
] | 1 | [] | [] | [] | 0 | [
"2ee7",
"7n61",
"7som",
"9ijj",
"9ntm",
"9nw3"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
3168,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
7,
6
] | 5 | true | Family | Spermatogenesis and Ciliary Microtubule-associated Protein | Spermatogenesis and Ciliary Microtubule-associated Protein | Spermatogenesis_Ciliary_MAP | 5 |
IPR052112 | 52,112 | EGFR Signaling Regulator Kinase | EGFR_SigReg_Kinase | Family | 3,252 | true | false | The protein family includes non-receptor tyrosine-protein and serine/threonine-protein kinases involved in cell signaling, particularly in relation to EGFR. The family members are implicated in various cellular processes such as cell spreading, migration, survival, growth, and proliferation. They act as downstream effe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14254"
] | [
"EGFR_SigReg_Kinase"
] | [
3252
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9842663",
"R-MMU-9842663",
"R-RNO-9842663"
] | [
"REACTOME:R-HSA-9842663",
"REACTOME:R-MMU-9842663",
"REACTOME:R-RNO-9842663"
] | 3 | [
"1cf4",
"2rf9",
"2rfe",
"4i21",
"4zjv"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3252
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
22,
17,
16,
15
] | 4 | true | Family | EGFR Signaling Regulator Kinase | EGFR Signaling Regulator Kinase | EGFR_SigReg_Kinase | 6 |
IPR052113 | 52,113 | FYVE-type Zinc Finger Domain-Containing Protein | FYVE-type_Zinc_Finger | Family | 3,246 | true | false | This family of proteins is involved in cellular processes related to adhesion and motility. Members of this family play a role in the dynamic assembly and disassembly of focal adhesions, which are critical for cell movement. They regulate the dephosphorylation of PTK2/FAK1, a key event in focal adhesion turnover, and i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39490"
] | [
"FYVE-type_Zinc_Finger"
] | [
3246
] | 1 | [] | [] | [] | 0 | [
"2rrf"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Megamimivirinae",
"Pseudomonadati",
"uncultured organism MedDCM-OCT-S09-C9"
] | [
3230,
2,
13,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
6,
6,
1
] | 5 | true | Family | FYVE-type Zinc Finger Domain-Containing Protein | FYVE-type Zinc Finger Domain-Containing Protein | FYVE-type_Zinc_Finger | 9 |
IPR052116 | 52,116 | Centrosome and Cilium Assembly Protein | Centro_Cilium_Assembly | Family | 2,651 | true | false | This family of proteins is involved in centrosome and cilium assembly and function. Members of this family are known to be components of the centrosome, specifically associated with centrioles. They play a crucial role in centrosome cohesion by forming a fiber-like linker between centrioles. Additionally, some family m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23170"
] | [
"Centro_Cilium_Assembly"
] | [
2651
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptococcus sanguinis SK408"
] | [
2650,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
7,
5,
6
] | 4 | true | Family | Centrosome and Cilium Assembly Protein | Centrosome and Cilium Assembly Protein | Centro_Cilium_Assembly | 9 |
IPR052117 | 52,117 | CRISPR-associated Cas10/Csm1 subtype III-A protein | Cas10/Csm1_subtype-III-A | Family | 1,157 | true | false | This family of proteins is involved in the CRISPR adaptive immune system, which defends against mobile genetic elements like viruses and plasmids. Members possess a single-strand-specific deoxyribonuclease (ssDNase) activity that digests ssDNA with both exo- and endonuclease actions. They are part of the type III-A Csm... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36528"
] | [
"Cas10/Csm1_subtype-III-A"
] | [
1157
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.-",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179"
] | [
"EC:2.7.7.-",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-7735",
"METACYC:PWY-7737",
"METACYC:PWY-7769",
"METACYC:PWY-7... | 18 | [
"3ung",
"3ur3",
"3w2v",
"3w2w",
"3x1l",
"4doz",
"4h4k",
"4uw2",
"4w8y",
"6ifk",
"6ifl",
"6ifn",
"6ifr",
"6ifu",
"6ify",
"6ifz",
"6ig0",
"6iqw",
"6kbd",
"6kc0",
"6mua",
"6mur",
"6mus",
"6mut",
"6muu",
"6nud",
"6nue",
"6o73",
"6o74",
"6o75",
"6o78",
"6o79"... | 65 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
160,
973,
24
] | 3 | [] | [] | 0 | true | Family | CRISPR-associated Cas10/Csm1 subtype III-A protein | CRISPR-associated Cas10/Csm1 subtype III-A protein | Cas10/Csm1_subtype-III-A | 7 |
IPR052118 | 52,118 | Rho GTPase-activating regulator | Rho-GAP_regulator | Family | 2,734 | true | false | This family of proteins includes Rho GTPase-activating proteins (GAPs) that function as regulators of Rho-type GTPases, converting them from an active GTP-bound state to an inactive GDP-bound state. They play a crucial role in cytoskeletal remodeling by controlling the activity of Rho GTPases such as RHOA, CDC42, and R... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46150"
] | [
"Rho-GAP_regulator"
] | [
2734
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-9013148",
"R-CEL-9013149",
"R-CEL-9013404",
"R-CEL-9013406",
"R-CEL-9013409",
"R-CEL-9013423",
"R-CEL-9035034",
"R-DME-9013148",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013406",
"R-DME-9013409",
"R-DME-9013423",
"R-DME-9035034",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-90134... | [
"REACTOME:R-CEL-9013148",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013404",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013409",
"REACTOME:R-CEL-9013423",
"REACTOME:R-CEL-9035034",
"REACTOME:R-DME-9013148",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013404",
"REACTOME:R-DME-9013406",
"REACTOM... | 32 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2734
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
7,
10,
6,
5
] | 6 | true | Family | Rho GTPase-activating regulator | Rho GTPase-activating regulator | Rho-GAP_regulator | 5 |
IPR052119 | 52,119 | Elongin BC-PRC2 Interaction & Viral Restriction | ElonginBC-PRC2_ViralRestrict | Family | 2,580 | true | false | The protein family includes scaffold proteins that bridge the PRC2/EZH2 complex with the elongin BC complex, regulating transcriptional status of PcG target genes in ESCs. They maintain low expression levels at PcG targets by recruiting elongin BC, limiting PRC2/EZH2 activity. They also interact with USP7, leading to H... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23187"
] | [
"ElonginBC-PRC2_ViralRestrict"
] | [
2580
] | 1 | [] | [] | [] | 0 | [
"7t5p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli",
"Eukaryota"
] | [
11,
2569
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
11,
14
] | 4 | true | Family | Elongin BC-PRC2 Interaction & Viral Restriction | Elongin BC-PRC2 Interaction & Viral Restriction | ElonginBC-PRC2_ViralRestrict | 9 |
IPR052120 | 52,120 | Fibronectin type III domain-containing protein 4/5 | FNDC_type_III_4/5 | Family | 2,464 | false | false | This family of proteins includes fibronectin type III domain-containing protein 4 and 5 (FNDC4/5). FDNC4 is involved in anti-inflammatory processes, particularly in the gastrointestinal tract. It interacts with macrophages to reduce the expression of pro-inflammatory genes and modulate macrophage functions such as phag... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14470"
] | [
""
] | [
2464
] | 1 | [] | [] | [] | 0 | [
"4lsd"
] | 1 | [
"PUB00076189",
"PUB00154986",
"PUB00154987",
"PUB00154988"
] | [
"22237023",
"27066907",
"30550785",
"24040023"
] | [
"A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.",
"FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.",
"Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.",
"Evidence against a beneficial effect of irisin i... | [
2012,
2016,
2018,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
2464
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
4,
5,
7
] | 4 | true | Family | Fibronectin type III domain-containing protein 4/5 | Fibronectin type III domain-containing protein 4/5 | FNDC_type_III_4/5 | 7 |
IPR052121 | 52,121 | F-box Protein Family Substrate Recognition Components | F-box_SCF_Substrate_Recog | Family | 3,045 | true | false | The F-box protein family is involved in the regulation of protein degradation via the ubiquitin-proteasome system. Members of this family function as substrate-recognition components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes. They are responsible for the ubiquitination of specific target proteins, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46550"
] | [
"F-box_SCF_Substrate_Recog"
] | [
3045
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8951664",
"R-HSA-983168"
] | [
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168"
] | 2 | [
"5hdw",
"9kbd",
"9kbf"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pimascovirales",
"Pseudomonadati"
] | [
3037,
5,
3
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
13,
42,
1,
4,
6,
7
] | 8 | true | Family | F-box Protein Family Substrate Recognition Components | F-box Protein Family Substrate Recognition Components | F-box_SCF_Substrate_Recog | 7 |
IPR052122 | 52,122 | Intracellular Trafficking and Signaling Regulator | Intracell_Traff_Signaling_Reg | Family | 2,420 | true | false | This family of proteins is involved in intracellular trafficking and the organization of membrane receptors. Members are known to interact with cytohesins, influencing ARF protein activation and potentially sequestering cytohesins in the cytoplasm to regulate their function. Some family members are implicated in synapt... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15963"
] | [
"Intracell_Traff_Signaling_Reg"
] | [
2420
] | 1 | [] | [] | [] | 0 | [
"2egk",
"2egn",
"2ego",
"2pnt",
"2z17",
"8j9c",
"8j9d"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
2295,
125
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
7,
5,
4
] | 6 | true | Family | Intracellular Trafficking and Signaling Regulator | Intracellular Trafficking and Signaling Regulator | Intracell_Traff_Signaling_Reg | 4 |
IPR052123 | 52,123 | Non-receptor Tyrosine Phosphatase | Non-rcpt_Tyr_Phosphatase | Family | 2,179 | true | false | This family of proteins includes non-receptor tyrosine phosphatases that play a role in modulating signaling pathways initiated by tyrosine phosphorylated cell surface receptors. They are involved in various cellular processes such as hematopoiesis, development, and cell fate determination. Members of this family conta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46257"
] | [
"Non-rcpt_Tyr_Phosphatase"
] | [
2179
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.3.48",
"R-CEL-6798695",
"R-DME-6798695",
"R-HSA-114604",
"R-HSA-1433559",
"R-HSA-201556",
"R-HSA-210990",
"R-HSA-389948",
"R-HSA-391160",
"R-HSA-432142",
"R-HSA-512988",
"R-HSA-5690714",
"R-HSA-6798695",
"R-HSA-877300",
"R-HSA-877312",
"R-HSA-9008059",
"R-HSA-909733",
"R-HSA-9... | [
"EC:3.1.3.48",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-HSA-114604",
"REACTOME:R-HSA-1433559",
"REACTOME:R-HSA-201556",
"REACTOME:R-HSA-210990",
"REACTOME:R-HSA-389948",
"REACTOME:R-HSA-391160",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-512988",
"REACTOME:R-HSA-5690714",
... | 52 | [
"1fpr",
"1gwz",
"1x6c",
"2b3o",
"2rmx",
"2yu7",
"3ps5",
"4gry",
"4grz",
"4gs0",
"4hjp",
"4hjq",
"6sm5",
"8yhi"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2179
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
14,
7,
8
] | 6 | true | Family | Non-receptor Tyrosine Phosphatase | Non-receptor Tyrosine Phosphatase | Non-rcpt_Tyr_Phosphatase | 5 |
IPR052124 | 52,124 | Rab9 effector with kelch motifs | Rab9_kelch_effector | Family | 2,462 | true | false | This family of proteins serves as effectors for the Rab9 GTPase, playing a crucial role in the transport process from endosomes to the trans-Golgi network (TGN). The members of this family are characterized by the presence of kelch motifs, which are typically involved in protein-protein interactions. Through these inte... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46647"
] | [
"Rab9_kelch_effector"
] | [
2462
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6811440",
"R-HSA-6811440",
"R-MMU-6811440",
"R-RNO-6811440"
] | [
"REACTOME:R-BTA-6811440",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440",
"REACTOME:R-RNO-6811440"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cuniculiplasma divulgatum",
"Eukaryota",
"mine drainage metagenome"
] | [
16,
1,
2443,
2
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
8,
6,
5,
8,
1,
2
] | 7 | true | Family | Rab9 effector with kelch motifs | Rab9 effector with kelch motifs | Rab9_kelch_effector | 1 |
IPR052125 | 52,125 | Kelch domain-containing protein 10 | KLHDC10 | Family | 2,335 | true | false | This family of proteins functions as substrate-recognition components of a Cul2-RING E3 ubiquitin-protein ligase complex, which is involved in the DesCEND pathway. They recognize specific C-terminal degrons in target proteins, leading to ubiquitination and subsequent degradation. These proteins are known to specificall... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46428"
] | [
"KLHDC10"
] | [
2335
] | 1 | [] | [] | [] | 0 | [
"9d8p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavobacterium tibetense"
] | [
2334,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
4,
4,
5
] | 6 | true | Family | Kelch domain-containing protein 10 | Kelch domain-containing protein 10 | KLHDC10 | 5 |
IPR052126 | 52,126 | Spindle_Organization_and_Thrombomodulin | Spindle_Org/Thrombomodulin | Family | 2,491 | true | false | This family of proteins includes structural components that stabilize and organize microtubule spindles during cell division, such as mitosis in embryonic somatic cells and meiosis in spermatocytes. Their function is influenced by the Ran pathway. Additionally, members of this family serve as specific endothelial cell ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24036"
] | [
"Spindle_Org/Thrombomodulin"
] | [
2491
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140875",
"R-HSA-202733",
"R-MMU-140875",
"R-MMU-202733"
] | [
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-202733",
"REACTOME:R-MMU-140875",
"REACTOME:R-MMU-202733"
] | 4 | [
"1dqb",
"1dx5",
"3gis",
"7t4r"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
2487
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
8,
2,
2,
3
] | 5 | true | Family | Spindle_Organization_and_Thrombomodulin | Spindle_Organization_and_Thrombomodulin | Spindle_Org/Thrombomodulin | 2 |
IPR052127 | 52,127 | STE12 transcription factor | STE12_transcription_factor | Family | 2,389 | true | false | The STE12 transcription factor family comprises proteins involved in various aspects of fungal development and stress response. Members of this family typically function as transcription factors that bind to specific DNA sequences to regulate gene expression. They play crucial roles in sexual reproduction, mating proce... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47427"
] | [
"STE12_transcription_factor"
] | [
2389
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2389
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Family | STE12 transcription factor | STE12 transcription factor | STE12_transcription_factor | 4 |
IPR052128 | 52,128 | Oxidoreductase NAD-binding domain-containing protein | Oxidoreductase_NAD-binding | Family | 2,191 | true | false | This family of proteins includes oxidoreductases that contain a domain for binding NAD, a coenzyme involved in redox reactions. These proteins are likely involved in various metabolic processes, where they catalyze the oxidation-reduction reactions of different substrates, transferring electrons from one molecule to an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46505"
] | [
"Oxidoreductase_NAD-binding"
] | [
2191
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"marine metagenome"
] | [
2185,
3,
3
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
6,
4,
7,
1,
4
] | 5 | true | Family | Oxidoreductase NAD-binding domain-containing protein | Oxidoreductase NAD-binding domain-containing protein | Oxidoreductase_NAD-binding | 1 |
IPR052129 | 52,129 | Spermadhesin-Link domain-containing protein | Spermadhesin-Link_domain | Family | 1,945 | true | false | This family of proteins includes members that are involved in various biological processes related to reproduction, cell division, and extracellular matrix organization. Some proteins in this family function as growth factors, stimulating cell division and hormone secretion in reproductive tissues. Others mediate the b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46908"
] | [
"Spermadhesin-Link_domain"
] | [
1945
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-MMU-6798695"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695"
] | 2 | [
"1sfp",
"2wno"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lymphocystis disease virus 2",
"Pseudomonadati",
"bioreactor metagenome"
] | [
1935,
2,
7,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2,
2,
4
] | 6 | true | Family | Spermadhesin-Link domain-containing protein | Spermadhesin-Link domain-containing protein | Spermadhesin-Link_domain | 4 |
IPR052130 | 52,130 | AEBP2/jing C2H2-type zinc-finger | AEBP2/jing_C2H2-Znf | Family | 2,265 | false | false | AEBP2 acts as an accessory subunit for the core Polycomb repressive complex 2, which mediates histone H3K27 trimethylation on chromatin leading to transcriptional repression of the affected target gene [ , , ]. Zinc finger protein jing from D. melanogaster is required for Egfr pathway function and MAPK activity in CNS ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46541"
] | [
""
] | [
2265
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-212300",
"R-BTA-3214841",
"R-DME-212300",
"R-DRE-212300",
"R-HSA-212300",
"R-HSA-3214841",
"R-MMU-212300",
"R-MMU-3214841"
] | [
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-3214841",
"REACTOME:R-DME-212300",
"REACTOME:R-DRE-212300",
"REACTOME:R-HSA-212300",
"REACTOME:R-HSA-3214841",
"REACTOME:R-MMU-212300",
"REACTOME:R-MMU-3214841"
] | 8 | [
"5wai",
"5y0u",
"6c23",
"6c24",
"6wkr",
"7kso",
"8eqv",
"8fyh",
"8t9g",
"8tas",
"8tb9",
"8vmi",
"8vml",
"8vnv",
"8vnz",
"9c8u",
"9dch"
] | 17 | [
"PUB00102932",
"PUB00107040",
"PUB00145423",
"PUB00161464",
"PUB00161465",
"PUB00161690",
"PUB00161691",
"PUB00161692"
] | [
"31959557",
"15225548",
"29499137",
"11152631",
"12015288",
"16510782",
"16648585",
"18036784"
] | [
"A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.",
"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.",
"Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.",
"Jing: a dow... | [
2020,
2004,
2018,
2001,
2002,
2006,
2006,
2008
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
92,
2165,
8
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
8,
4,
6
] | 5 | true | Family | AEBP2/jing C2H2-type zinc-finger | AEBP2/jing C2H2-type zinc-finger | AEBP2/jing_C2H2-Znf | 6 |
IPR052131 | 52,131 | ATRX domain-containing protein | ATRX_domain-containing | Family | 2,383 | true | true | ATRX is a chromatin-associated protein involved in transcriptional regulation, chromatin remodelling, DNA replication, and repair. It was originally identified due to mutations in the ATRX gene causing ATR-X syndrome, a severe form of X-linked mental retardation. ATRX plays a key role in stabilising G-rich regions by r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46357"
] | [
"ATRX_domain-containing"
] | [
2383
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.12",
"R-HSA-9670095",
"R-HSA-9670613",
"R-HSA-9670615",
"R-MMU-9670095"
] | [
"EC:3.6.4.12",
"REACTOME:R-HSA-9670095",
"REACTOME:R-HSA-9670613",
"REACTOME:R-HSA-9670615",
"REACTOME:R-MMU-9670095"
] | 5 | [
"2jm1",
"2lbm",
"2ld1",
"3ql9",
"3qla",
"3qlc",
"3qln",
"4w5a"
] | 8 | [
"PUB00129121",
"PUB00161133"
] | [
"21653732",
"34162889"
] | [
"Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.",
"ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Neisseria lisongii"
] | [
2382,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
17,
17,
5
] | 5 | true | Family | ATRX domain-containing protein | ATRX domain-containing protein | ATRX_domain-containing | 6 |
IPR052133 | 52,133 | Immune Signaling and Apoptosis Regulator | Immune_Signaling-Apoptosis_Reg | Family | 2,183 | true | false | This family of proteins includes transmembrane adaptors and mediators that function as scaffolds for Src-family kinases and other signaling proteins in immune cells. They are involved in signaling transduction pathways such as major histocompatibility complex class II (MHC-II) in B cells, enhancing calcium response and... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12044"
] | [
"Immune_Signaling-Apoptosis_Reg"
] | [
2183
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-111446",
"R-HSA-111453",
"R-HSA-193648",
"R-HSA-6802952",
"R-HSA-8862803",
"R-HSA-8952158",
"R-HSA-9607240",
"R-HSA-9614657",
"R-MMU-111446",
"R-MMU-111453",
"R-MMU-193648",
"R-RNO-111446",
"R-RNO-111453",
"R-RNO-193648"
] | [
"REACTOME:R-HSA-111446",
"REACTOME:R-HSA-111453",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-8862803",
"REACTOME:R-HSA-8952158",
"REACTOME:R-HSA-9607240",
"REACTOME:R-HSA-9614657",
"REACTOME:R-MMU-111446",
"REACTOME:R-MMU-111453",
"REACTOME:R-MMU-193648",
"REACTOME:R-RN... | 14 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2183
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
15,
9,
17
] | 4 | true | Family | Immune Signaling and Apoptosis Regulator | Immune Signaling and Apoptosis Regulator | Immune_Signaling-Apoptosis_Reg | 4 |
IPR052134 | 52,134 | Interleukin enhancer-binding factor 2 | ILF2 | Family | 1,972 | true | false | This family of proteins interacts with chromatin and forms stable heterodimers with interleukin enhancer-binding factor 3 (ILF3). They are involved in various biological processes, including transcription, innate immunity, and cell growth. These proteins are crucial for the nuclear reshuttling of ILF3 isoforms and form... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46447"
] | [
"ILF2"
] | [
1972
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6798695",
"R-DME-9833482",
"R-DRE-6798695",
"R-DRE-9833482",
"R-HSA-6798695",
"R-HSA-9833482",
"R-MMU-6798695",
"R-MMU-9833482",
"R-RNO-6798695",
"R-RNO-9833482",
"R-XTR-6798695",
"R-XTR-9833482"
] | [
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-9833482",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-9833482",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-9833482",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-9833482",
"REACTOME:R-XTR-6798695",
"REACTOM... | 12 | [
"4at7",
"4at8",
"4at9",
"4atb"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archangium gephyra",
"Metazoa",
"bird metagenome"
] | [
1,
1970,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
7,
2,
8
] | 6 | true | Family | Interleukin enhancer-binding factor 2 | Interleukin enhancer-binding factor 2 | ILF2 | 1 |
IPR052135 | 52,135 | Tumor Necrosis Factor Receptor Superfamily Member 5 | TNFRSF5 | Family | 1,431 | true | false | The Tumor Necrosis Factor Receptor Superfamily Member 5 family comprises receptors that bind to TNFSF5/CD40LG. These receptors are pivotal in immune system regulation, particularly in macrophages and B cells. Upon ligand binding, they initiate signaling cascades involving TRAF6 and MAP3K8, which subsequently lead to th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46875"
] | [
"TNFRSF5"
] | [
1431
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-198933",
"R-BTA-5668541",
"R-BTA-5676594",
"R-HSA-198933",
"R-HSA-5668541",
"R-HSA-5676594",
"R-MMU-198933",
"R-MMU-5668541",
"R-MMU-5676594",
"R-SSC-198933",
"R-SSC-5668541",
"R-SSC-5676594"
] | [
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-5668541",
"REACTOME:R-BTA-5676594",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5676594",
"REACTOME:R-SSC-198933",
"REACTOME:R-SSC-5668541",
"REACTOME:R-... | 12 | [
"3qd6",
"5dmi",
"5dmj",
"5ihl",
"6fax",
"6pe8",
"6pe9",
"7p3i",
"8yx1",
"8yx9"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Viruses"
] | [
1426,
5
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
9,
2,
11
] | 4 | true | Family | Tumor Necrosis Factor Receptor Superfamily Member 5 | Tumor Necrosis Factor Receptor Superfamily Member 5 | TNFRSF5 | 7 |
IPR052136 | 52,136 | Adipolin/Erythroferrone-related | Adipolin/Erythroferrone-rel | Family | 1,679 | true | false | This family of proteins includes adipokines and iron-regulatory hormones with diverse roles in metabolism, iron homeostasis, and cellular signaling. Members are secreted by adipocytes and erythroblasts, influencing glucose metabolism in liver and adipose tissue, and regulating iron absorption and mobilization. They are... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24019"
] | [
"Adipolin/Erythroferrone-rel"
] | [
1679
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1679
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4,
5
] | 4 | true | Family | Adipolin/Erythroferrone-related | Adipolin/Erythroferrone-related | Adipolin/Erythroferrone-rel | 5 |
IPR052137 | 52,137 | Universal small ribosomal subunit uS15 | uS15_ribosomal | Family | 1,589 | true | false | This family of proteins is involved in the structure and function of the ribosome, which is essential for protein synthesis in all living cells. Members of this family are part of the small ribosomal subunit and play a role in the assembly and stability of the ribosome. One member has been noted to be essential for gut... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46685"
] | [
"uS15_ribosomal"
] | [
1589
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5389840",
"R-CEL-5419276",
"R-CEL-9937383",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-9937383",
"R-DRE-5389840",
"R-DRE-5419276",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383",
"R-RNO-5389840",
"R-RNO-54192... | [
"REACTOME:R-CEL-5389840",
"REACTOME:R-CEL-5419276",
"REACTOME:R-CEL-9937383",
"REACTOME:R-DME-5389840",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-9937383",
"REACTOME:R-DRE-5389840",
"REACTOME:R-DRE-5419276",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOM... | 18 | [
"3j9m",
"3jd5",
"5aj3",
"5aj4",
"6gaw",
"6gaz",
"6neq",
"6nf8",
"6nu2",
"6nu3",
"6rw4",
"6rw5",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5i",
"7a5k",
"7l08",
"7nqh",
"7nql"... | 77 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1589
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3,
1,
4
] | 6 | true | Family | Universal small ribosomal subunit uS15 | Universal small ribosomal subunit uS15 | uS15_ribosomal | 7 |
IPR052138 | 52,138 | GATA transcription factor 21-like | GAT21-like | Family | 1,931 | true | true | The GATA zinc finger domain-containing protein family includes transcriptional regulators that bind specific DNA motifs to modulate various biological processes. Members of this family are involved in chloroplast development, influencing chlorophyll biosynthesis and plant growth. They play roles in cytokinin and gibber... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47255"
] | [
"GATA_ZnFinger_Domain"
] | [
1931
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1931
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
5,
10
] | 3 | true | Family | GATA transcription factor 21-like | GATA transcription factor 21-like | GAT21-like | 9 |
IPR052139 | 52,139 | Methylosome Component WDR77 | Methylosome_Comp_WDR77 | Family | 1,516 | true | false | This family of proteins includes non-catalytic components of the methylosome complex, which is involved in the post-translational modification of specific arginines to dimethylarginines in spliceosomal Sm proteins and histones. These modifications are crucial for targeting Sm proteins to the survival of motor neurons (... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46853"
] | [
"Methylosome_Comp_WDR77"
] | [
1516
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-191859",
"R-BTA-3214858",
"R-DME-3214858",
"R-DME-9037629",
"R-HSA-191859",
"R-HSA-3214858",
"R-MMU-191859",
"R-MMU-3214858",
"R-RNO-191859",
"R-RNO-3214858"
] | [
"REACTOME:R-BTA-191859",
"REACTOME:R-BTA-3214858",
"REACTOME:R-DME-3214858",
"REACTOME:R-DME-9037629",
"REACTOME:R-HSA-191859",
"REACTOME:R-HSA-3214858",
"REACTOME:R-MMU-191859",
"REACTOME:R-MMU-3214858",
"REACTOME:R-RNO-191859",
"REACTOME:R-RNO-3214858"
] | 10 | [
"4g56",
"4gqb",
"4x60",
"4x61",
"4x63",
"5c9z",
"5emj",
"5emk",
"5eml",
"5emm",
"5fa5",
"6ckc",
"6k1s",
"6rll",
"6rlq",
"6ugh",
"6uxx",
"6uxy",
"6v0n",
"6v0o",
"6v0p",
"7bo7",
"7kib",
"7kic",
"7kid",
"7l1g",
"7m05",
"7mx7",
"7mxa",
"7mxc",
"7mxg",
"7mxn"... | 83 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1516
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
3,
3
] | 5 | true | Family | Methylosome Component WDR77 | Methylosome Component WDR77 | Methylosome_Comp_WDR77 | 2 |
IPR052140 | 52,140 | Developmental Signaling Hedgehog-like | Dev_Signal_Hedgehog-like | Family | 1,556 | true | false | This family of proteins includes members that are essential for various developmental patterning events. They function as intercellular signals that are crucial for proper morphological development. One member is specifically required for cuticle shedding and the formation of normal alae structures, which are vital for... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46706"
] | [
"Dev_Signal_Hedgehog-like"
] | [
1556
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
4,
1550,
2
] | 3 | [
"Caenorhabditis elegans"
] | [
17
] | 1 | true | Family | Developmental Signaling Hedgehog-like | Developmental Signaling Hedgehog-like | Dev_Signal_Hedgehog-like | 1 |
IPR052142 | 52,142 | Calmodulin Regulator PCP4-like | Calmodulin_Regulator_PCP4-like | Family | 1,240 | true | false | This family of proteins functions as modulators of calcium-binding by calmodulin, regulating its activity and the various processes it controls. Members of this family are characterized by an intrinsically disordered nature, with some residual structure primarily in the IQ domain. This domain is responsible for mediati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15359"
] | [
"Calmodulin_Regulator_PCP4-like"
] | [
1240
] | 1 | [] | [] | [] | 0 | [
"2n77"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1240
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
2,
7
] | 5 | true | Family | Calmodulin Regulator PCP4-like | Calmodulin Regulator PCP4-like | Calmodulin_Regulator_PCP4-like | 9 |
IPR052143 | 52,143 | Mitochondrial Large Ribosomal Subunit bL36m | Mitoribosomal_bL36m | Family | 1,141 | true | false | This family of proteins is involved in the structure and function of mitochondrial ribosomes, which are specialized for the synthesis of proteins encoded by the mitochondrial genome. These proteins are integral components of the large subunit of mitoribosomes and are thought to play a role in the cotranslational integr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46909"
] | [
"Mitoribosomal_bL36m"
] | [
1141
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5389840",
"R-DRE-5419276",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383",
"R-RNO-5389840",
"R-RNO-5419276",
"R-RNO-9937383"
] | [
"REACTOME:R-DRE-5389840",
"REACTOME:R-DRE-5419276",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383",
"REACTOME:R-RNO-5389840",
"REACTOME:R-RNO-5419276",
"REACTOM... | 12 | [
"3j6b",
"3j7y",
"3j9m",
"4ce4",
"4v19",
"5aj4",
"5ool",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5i",
"7a5j",
"7a5k",
"7l08",
"7l20"... | 77 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"candidate division CPR3 bacterium"
] | [
1140,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1,
1,
1,
1,
1,
1
] | 8 | true | Family | Mitochondrial Large Ribosomal Subunit bL36m | Mitochondrial Large Ribosomal Subunit bL36m | Mitoribosomal_bL36m | 3 |
IPR052144 | 52,144 | piRNA biogenesis EXD1-related protein | piRNA_biogenesis_EXD1 | Family | 1,385 | true | false | This family of proteins is involved in the piRNA metabolic process, which is crucial for the repression of transposable elements during meiosis. Members of this family form part of the PET complex, a multiprotein assembly essential for piRNA processing during spermatogenesis. These proteins act as RNA adapters within t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46628"
] | [
"piRNA_biogenesis_EXD1"
] | [
1385
] | 1 | [] | [] | [] | 0 | [
"5fiq",
"5fis",
"7c42",
"7c43",
"7c45",
"7c47",
"7c4b",
"7c4c"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1385
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
1,
3,
3
] | 6 | true | Family | piRNA biogenesis EXD1-related protein | piRNA biogenesis EXD1-related protein | piRNA_biogenesis_EXD1 | 4 |
IPR052145 | 52,145 | Mediator complex and homeobox domain-containing protein | Mediator/Homeobox_domain | Family | 3,858 | true | false | This family of proteins includes components of the Mediator complex, which are coactivators involved in the transcription regulation of RNA polymerase II-dependent genes. They function as a bridge between gene-specific regulatory proteins and the basal transcription machinery, facilitating the assembly of a preinitiati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24330"
] | [
"Mediator/Homeobox_domain"
] | [
3858
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
39,
3805,
8,
6
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus"
] | [
2,
1,
10,
1,
2
] | 5 | true | Family | Mediator complex and homeobox domain-containing protein | Mediator complex and homeobox domain-containing protein | Mediator/Homeobox_domain | 9 |
IPR052146 | 52,146 | High-osmolarity-induced transcription | HOT1 | Family | 1,418 | true | false | The HOT1 family proteins are involved in the transcriptional response to osmotic stress. They are required for the complete activation of genes that respond to changes in osmotic conditions, ensuring cellular adaptation and survival. Members of the HOT1 family may also interact with other proteins, such as HOG1, to fac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37784"
] | [
"HOT1"
] | [
1418
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1418
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
4
] | 1 | true | Family | High-osmolarity-induced transcription | High-osmolarity-induced transcription | HOT1 | 5 |
IPR052147 | 52,147 | Phloem protein 2-like/Lectin | PP2-like/Lectin | Family | 1,849 | false | false | Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances. PP2-like genes have been identified in many plant species, indicating a wide distribution o... | [
"GO:0030246"
] | [
"carbohydrate binding"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR48478"
] | [
""
] | [
1849
] | 1 | [] | [] | [] | 0 | [
"7vs6",
"7vub",
"7vwb",
"7w4b",
"7yaq",
"8jmq",
"8jmr"
] | 7 | [
"PUB00058182",
"PUB00155265",
"PUB00155266",
"PUB00155267"
] | [
"12529520",
"26597132",
"30765478",
"20442276"
] | [
"Diversity of the superfamily of phloem lectins (phloem protein 2) in angiosperms.",
"Luffa acutangula agglutinin: Primary structure determination and identification of a tryptophan residue involved in its carbohydrate-binding activity using mass spectrometry.",
"An Arabidopsis TIR-Lectin Two-Domain Protein Con... | [
2003,
2015,
2019,
2010
] | 4 | [
"IPR025886"
] | [] | 1 | 0 | 1 | [
"Magnoliopsida"
] | [
1849
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
28,
4,
12
] | 3 | true | Family | Phloem protein 2-like/Lectin | Phloem protein 2-like/Lectin | PP2-like/Lectin | 4 |
IPR052148 | 52,148 | Dehydrogenase/reductase SDR family member 7C | SDR_family_member_7C | Family | 1,179 | true | false | The Dehydrogenase/reductase SDR family member 7C proteins are NADH-dependent oxidoreductases involved in the oxidation of all-trans-retinol to all-trans-retinal. They play a crucial role in the regulation of cardiac and skeletal muscle metabolic functions, maintaining Ca(2+) intracellular homeostasis by repressing Ca(2... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44668"
] | [
"SDR_family_member_7C"
] | [
1179
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Gnathostomata"
] | [
5,
1174
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
3
] | 4 | true | Family | Dehydrogenase/reductase SDR family member 7C | Dehydrogenase/reductase SDR family member 7C | SDR_family_member_7C | 7 |
IPR052149 | 52,149 | 17-beta-hydroxysteroid dehydrogenase type 3-like | 17-beta-HSD3-like | Family | 1,620 | true | false | This family of proteins includes members that are structurally related to the short-chain dehydrogenases/reductases (SDR) superfamily, specifically the 17-beta-hydroxysteroid dehydrogenase (17-beta-HSD) type 3 subfamily. These enzymes are typically involved in the metabolism of steroid hormones, which is crucial for va... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44889"
] | [
"17-beta-HSD3-like"
] | [
1620
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1620
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
5,
3,
3
] | 5 | true | Family | 17-beta-hydroxysteroid dehydrogenase type 3-like | 17-beta-hydroxysteroid dehydrogenase type 3-like | 17-beta-HSD3-like | 1 |
IPR052150 | 52,150 | Methionine-R-sulfoxide reductase B1 | MsrB_Met_sulfoxide_reductase | Family | 1,168 | true | false | The Methionine-R-sulfoxide reductase B1 family comprises enzymes that catalyze the reduction of methionine (R)-sulfoxide to methionine, a reaction that can reverse post-translational modifications or oxidative stress effects. Members of the family are involved in regulating actin assembly by interacting with MICAL prot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46755"
] | [
"MsrB_Met_sulfoxide_reductase"
] | [
1168
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.8.4.12",
"1.8.4.14",
"R-DRE-5676934",
"R-HSA-5676934",
"R-MMU-5676934",
"R-RNO-5676934",
"R-SSC-5676934"
] | [
"EC:1.8.4.12",
"EC:1.8.4.14",
"REACTOME:R-DRE-5676934",
"REACTOME:R-HSA-5676934",
"REACTOME:R-MMU-5676934",
"REACTOME:R-RNO-5676934",
"REACTOME:R-SSC-5676934"
] | 7 | [
"2kv1",
"3mao"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa",
"bird metagenome"
] | [
1167,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
2,
3
] | 4 | true | Family | Methionine-R-sulfoxide reductase B1 | Methionine-R-sulfoxide reductase B1 | MsrB_Met_sulfoxide_reductase | 6 |
IPR052151 | 52,151 | Complex I LYR motif-containing protein | Complex_I_LYR | Family | 1,088 | true | false | This family of proteins contains the LYR motif, which is indicative of a role in mitochondrial complex I assembly or function. Members of this family are likely involved in the biogenesis and maintenance of the mitochondrial respiratory chain, specifically complex I, which is responsible for the initial step of electro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47061"
] | [
"Complex_I_LYR"
] | [
1088
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1088
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
1
] | 4 | true | Family | Complex I LYR motif-containing protein | Complex I LYR motif-containing protein | Complex_I_LYR | 7 |
IPR052152 | 52,152 | Multicopper oxidase LPR1/LPR2 | LPR1/LPR2 | Family | 1,153 | false | false | Multicopper oxidase LPR1 and LPR2 are involved in copper homeostasis and oxidative stress response, particularly in the context of root growth and inorganic phosphate homeostasis in plants. Members of the family function in a common pathway that modulates root meristem activity in response to phosphate availability [ ,... | [
"GO:0016491",
"GO:0016036"
] | [
"oxidoreductase activity",
"cellular response to phosphate starvation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR48461"
] | [
""
] | [
1153
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155257",
"PUB00155258",
"PUB00155259"
] | [
"17496893",
"19666499",
"20071375"
] | [
"Root tip contact with low-phosphate media reprograms plant root architecture.",
"ER-resident proteins PDR2 and LPR1 mediate the developmental response of root meristems to phosphate availability.",
"The function of LPR1 is controlled by an element in the promoter and is independent of SUMO E3 Ligase SIZ1 in re... | [
2007,
2009,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halovenus salina",
"bioreactor metagenome"
] | [
8,
1143,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
13,
6
] | 3 | true | Family | Multicopper oxidase LPR1/LPR2 | Multicopper oxidase LPR1/LPR2 | LPR1/LPR2 | 5 |
IPR052153 | 52,153 | DEVIL/RTFL Small Polypeptides | DVL/RTFL_small_peptides | Family | 727 | true | false | The DVL/RTFL small polypeptides family consists of regulatory molecules that play a crucial role in coordinating cellular responses essential for plant differentiation, growth, and development. Members of this family are involved in modulating processes such as polar cell proliferation in lateral organs and the recruit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47855"
] | [
"DVL/RTFL_small_peptides"
] | [
727
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
727
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
3,
6
] | 3 | true | Family | DEVIL/RTFL Small Polypeptides | DEVIL/RTFL Small Polypeptides | DVL/RTFL_small_peptides | 9 |
IPR052154 | 52,154 | Keratin-associated protein type 2-like | KRTAP_type_2-like | Family | 320 | true | true | Keratin-associated protein type 2 (KRTAP2) is involved in the structural integrity of hair. Members of this family are hair keratin-associated proteins (KRTAPs) that play a crucial role in the hair cortex. They are part of an interfilamentous matrix that embeds hair keratin intermediate filaments. These proteins are es... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48425"
] | [
""
] | [
320
] | 1 | [
"REACTOME"
] | [
"R-HSA-6805567"
] | [
"REACTOME:R-HSA-6805567"
] | 1 | [] | 0 | [
"PUB00090807",
"PUB00155233",
"PUB00155234",
"PUB00155235"
] | [
"16382671",
"8962491",
"25208914",
"1714783"
] | [
"Human hair keratin-associated proteins.",
"The role of keratin proteins and their genes in the growth, structure and properties of hair.",
"Mammalian keratin associated proteins (KRTAPs) subgenomes: disentangling hair diversity and adaptation to terrestrial and aquatic environments.",
"Structure and biochemi... | [
2005,
1997,
2014,
1991
] | 4 | [
"IPR002494"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
320
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
1
] | 3 | true | Family | Keratin-associated protein type 2-like | Keratin-associated protein type 2-like | KRTAP_type_2-like | 3 |
IPR052155 | 52,155 | Bacterial biofilm regulation/maintenance | Biofilm_reg_signaling | Family | 119,275 | true | true | This family of proteins is involved in the regulation of bacterial biofilm formation and maintenance [ ]. Members of this family function in signaling cascades that control the transition between cellular states, such as motility and adhesion. Key activities include the synthesis and degradation of cyclic-di-GMP (c-di-... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44757"
] | [
"Biofilm_reg_signaling"
] | [
119275
] | 1 | [] | [] | [] | 0 | [
"3ewk",
"4rnf",
"4rnh",
"5m3c",
"5xgb",
"5xgd",
"5xge",
"9bgv",
"9bkv",
"9cdr",
"9ce0",
"9clo",
"9cmf"
] | 13 | [
"PUB00151466",
"PUB00154989",
"PUB00154990"
] | [
"23708798",
"16237027",
"23729646"
] | [
"The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control.",
"NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine.",
"NO-induced biofilm dispersion in Pseudomonas aeruginosa is mediated by an MHYT d... | [
2013,
2005,
2013
] | 3 | [] | [
"IPR012226"
] | 0 | 1 | 0 | [
"Agrobacterium phage Atu_ph07",
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1,
1056,
116451,
191,
1576
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
1,
3,
1
] | 3 | true | Family | Bacterial biofilm regulation/maintenance | Bacterial biofilm regulation/maintenance | Biofilm_reg_signaling | 8 |
IPR052156 | 52,156 | Branched-Chain Amino Acid Transport ATP-binding Protein LivF | BCAA_Transport_ATP-bd_LivF | Family | 67,647 | true | false | The LivF protein family is involved in the transport of branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine. Members of this family function as components of high-affinity transport systems that do not require sodium ions for activity. These systems are specialized for the uptake of BCAAs, which ... | [] | [] | [] | 0 | [
"PANTHER",
"CDD"
] | [
"PTHR43820",
"cd03224"
] | [
"BCAA_Transport_ATP-bd_LivF",
"ABC_TM1139_LivF_branched"
] | [
67365,
63288
] | 2 | [] | [] | [] | 0 | [
"1ji0"
] | 1 | [
"PUB00013904",
"PUB00014770",
"PUB00043654",
"PUB00072504",
"PUB00080850",
"PUB00080851",
"PUB00080853",
"PUB00080855",
"PUB00080856",
"PUB00116582"
] | [
"11435397",
"10529352",
"11421270",
"12370001",
"11551790",
"9886914",
"10748248",
"15667317",
"16305368",
"1718037"
] | [
"The human ATP-binding cassette (ABC) transporter superfamily.",
"ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans.",
"The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms.",
"Phy... | [
2001,
1999,
2001,
2002,
2001,
1999,
2000,
2005,
2004,
1991
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
1735,
64310,
107,
1,
1494
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Branched-Chain Amino Acid Transport ATP-binding Protein LivF | Branched-Chain Amino Acid Transport ATP-binding Protein LivF | BCAA_Transport_ATP-bd_LivF | 2 |
IPR052157 | 52,157 | Branched-chain amino acid transport system permease | BCAA_transport_permease | Family | 66,960 | true | false | The LivHM family is involved in the high-affinity transport of branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine. Members of this family function as part of a binding-protein-dependent transport system, which is likely responsible for the translocation of BCAAs across the cell membrane without ... | [] | [] | [] | 0 | [
"PANTHER",
"CDD"
] | [
"PTHR11795",
"cd06582"
] | [
"BCAA_transport_permease",
"TM_PBP1_LivH_like"
] | [
65120,
66237
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002368",
"PUB00002417",
"PUB00003865",
"PUB00019227",
"PUB00071938",
"PUB00072504",
"PUB00072659",
"PUB00080124",
"PUB00080854",
"PUB00094023",
"PUB00113457",
"PUB00120789",
"PUB00120790",
"PUB00120792",
"PUB00121287"
] | [
"2229036",
"3891753",
"7934906",
"2195019",
"8003968",
"12370001",
"9593292",
"18535149",
"16254912",
"14702302",
"17723295",
"1970642",
"16375896",
"17764951",
"3009409"
] | [
"Binding protein-dependent transport systems.",
"The complete nucleotide sequences of the Escherichia coli LIV-BP and LS-BP genes. Implications for the mechanism of high-affinity branched-chain amino acid transport.",
"Bacterial binding protein-dependent permeases: characterization of distinctive signatures for... | [
1990,
1985,
1994,
1990,
1994,
2002,
1998,
2008,
2005,
2004,
2007,
1990,
2006,
2007,
1986
] | 15 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
1676,
63789,
67,
3,
1425
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Branched-chain amino acid transport system permease | Branched-chain amino acid transport system permease | BCAA_transport_permease | 2 |
IPR052158 | 52,158 | Isonitrile Hydratase and Quaternary Amine Regulator | INH-QAR | Family | 68,960 | true | false | This family of proteins includes enzymes and transcriptional regulators. The enzymes catalyze the hydration of isonitriles to formamides, likely playing a role in detoxification processes. They are sensitive to thiol and oxidizing reagents. The transcriptional regulators are involved in the metabolism of quaternary ami... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43130"
] | [
"INH-QAR"
] | [
68960
] | 1 | [] | [] | [] | 0 | [
"3bhn",
"3er6",
"3ewn",
"3gra",
"3mgk",
"3non",
"3noo",
"3noq",
"3nor",
"3nov",
"6ni4",
"6ni5",
"6ni6",
"6ni7",
"6ni8",
"6ni9",
"6nia",
"6npq",
"6und",
"6unf",
"7l9q",
"7l9s",
"7l9w",
"7l9z",
"7la0",
"7la3",
"7lav",
"7lax",
"7lb9",
"7lbh",
"7lbi",
"7lcx"... | 52 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
364,
62508,
5882,
206
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Isonitrile Hydratase and Quaternary Amine Regulator | Isonitrile Hydratase and Quaternary Amine Regulator | INH-QAR | 9 |
IPR052160 | 52,160 | Gypsy Retrotransposon Integrase-like | Gypsy_RT_Integrase-like | Family | 13,016 | true | false | This family of proteins includes integrase-like enzymes that are typically encoded by gypsy retrotransposons. These enzymes are responsible for integrating the retrotransposon DNA into the host genome, a process that is crucial for the replication and mobilization of these mobile genetic elements. The integrase-like pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47266"
] | [
"Gypsy_RT_Integrase-like"
] | [
13016
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Simian foamy virus",
"mine drainage metagenome"
] | [
8,
12183,
824,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
31,
1
] | 3 | true | Family | Gypsy Retrotransposon Integrase-like | Gypsy Retrotransposon Integrase-like | Gypsy_RT_Integrase-like | 6 |
IPR052161 | 52,161 | Mycobacterial Acyl-CoA Dehydrogenase | Mycobact_Acyl-CoA_DH | Family | 33,079 | true | false | The Acyl-CoA dehydrogenase family is involved in the beta-oxidation of cholesterol catabolism, contributing to the virulence of Mycobacterium tuberculosis by increasing the efficiency of this metabolic pathway. Members of this family catalyze the dehydrogenation of various CoA esters, including those with steroid side ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43292"
] | [
"Mycobact_Acyl-CoA_DH"
] | [
33079
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.3.99.-",
"PWY-6061",
"PWY-6279",
"PWY-6672",
"PWY-6944",
"PWY-6945",
"PWY-6946",
"PWY-6948",
"PWY-7552",
"PWY-7636",
"PWY-8151",
"PWY-8152",
"PWY-8155"
] | [
"EC:1.3.99.-",
"METACYC:PWY-6061",
"METACYC:PWY-6279",
"METACYC:PWY-6672",
"METACYC:PWY-6944",
"METACYC:PWY-6945",
"METACYC:PWY-6946",
"METACYC:PWY-6948",
"METACYC:PWY-7552",
"METACYC:PWY-7636",
"METACYC:PWY-8151",
"METACYC:PWY-8152",
"METACYC:PWY-8155"
] | 13 | [
"4x28",
"6wy8",
"6wy9",
"8hk0"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
70,
31859,
55,
2,
1093
] | 5 | [] | [] | 0 | true | Family | Mycobacterial Acyl-CoA Dehydrogenase | Mycobacterial Acyl-CoA Dehydrogenase | Mycobact_Acyl-CoA_DH | 2 |
IPR052162 | 52,162 | Two-component sensor kinase/Photoreceptor | Sensor_kinase/Photoreceptor | Family | 35,390 | true | false | This family of proteins includes sensor kinases and photoreceptors that are part of two-component regulatory systems, which are typically involved in environmental response and signal transduction. Members of this family are known to play roles in processes such as methyl sulfide metabolism, methanogenesis, and photore... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43304"
] | [
"Sensor_kinase/Photoreceptor"
] | [
35390
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"2vea",
"3eeh",
"3lyx",
"3mr0",
"3nja",
"3zq5",
"8js5",
"8js6",
"8js7",
"8rvx"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
4516,
29923,
285,
7,
659
] | 5 | [] | [] | 0 | true | Family | Two-component sensor kinase/Photoreceptor | Two-component sensor kinase/Photoreceptor | Sensor_kinase/Photoreceptor | 9 |
IPR052163 | 52,163 | Diguanylate Cyclase/Regulatory Protein | DGC-Regulatory_Protein | Family | 21,601 | true | false | This family of proteins includes diguanylate cyclases and regulatory proteins involved in the synthesis of cyclic-di-GMP (c-di-GMP) and the regulation of nitrogen fixation. Diguanylate cyclases catalyze the formation of c-di-GMP from GTP, a signaling molecule that controls bacterial cell surface-associated traits, such... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46663"
] | [
"DGC-Regulatory_Protein"
] | [
21601
] | 1 | [
"EC"
] | [
"2.7.7.65"
] | [
"EC:2.7.7.65"
] | 1 | [
"2gj3",
"3icl",
"4iob",
"4urg",
"4urq",
"4urs",
"4yme",
"7a7e"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
21062,
3,
66,
2,
468
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Diguanylate Cyclase/Regulatory Protein | Diguanylate Cyclase/Regulatory Protein | DGC-Regulatory_Protein | 4 |
IPR052164 | 52,164 | Anthracycline and Secondary Metabolite Biosynthesis Protein | Anthracycline_SecMetBiosynth | Family | 29,833 | true | false | This family of proteins includes enzymes involved in various biosynthetic pathways, including the production of anthracyclines, which are aromatic polyketide antibiotics with significant cytotoxicity used in cancer chemotherapy. Members of this family participate in key steps of the anthracycline biosynthesis, such as ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33993"
] | [
"Anthracycline_SecMetBiosynth"
] | [
29833
] | 1 | [] | [] | [] | 0 | [
"2r6u",
"3oxh",
"8eo9",
"8epy",
"8stb",
"9jt3"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
219,
28153,
1294,
167
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
2,
17
] | 3 | true | Family | Anthracycline and Secondary Metabolite Biosynthesis Protein | Anthracycline and Secondary Metabolite Biosynthesis Protein | Anthracycline_SecMetBiosynth | 5 |
IPR052165 | 52,165 | Membrane-associated protease and related proteins | Membrane_assoc_protease | Family | 20,676 | true | false | This family of proteins includes membrane-bound proteases and uncharacterized membrane proteins. The protease member is known to cleave substrates preferentially near hydrophobic or aromatic residues and can degrade casein and a stomatin homolog in vitro. Its activity is regulated by inhibition with divalent metal cati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33507"
] | [
"Membrane_assoc_protease"
] | [
20676
] | 1 | [] | [] | [] | 0 | [
"2deo",
"2k5h",
"3bpp",
"3viv",
"3wg5",
"3wwv",
"6m4b",
"8z5g"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
855,
19350,
10,
460,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Membrane-associated protease and related proteins | Membrane-associated protease and related proteins | Membrane_assoc_protease | 4 |
IPR052166 | 52,166 | Diverse substrate specificity acyl-CoA dehydrogenase | Diverse_Acyl-CoA_DH | Family | 24,472 | true | false | This family of proteins includes acyl-CoA dehydrogenases with diverse substrate specificities, including broad-specificity enzymes that prefer long-chain substrates and those involved in specific metabolic pathways. Members are key in various biochemical processes, such as the oxidation of fatty acids and the assimilat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42803"
] | [
"Diverse_Acyl-CoA_DH"
] | [
24472
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.3.8.1",
"PWY-3941",
"PWY-8182"
] | [
"EC:1.3.8.1",
"METACYC:PWY-3941",
"METACYC:PWY-8182"
] | 3 | [
"6ijc",
"6kpt",
"6kri",
"6ks9",
"6ksa",
"6ksb",
"6kse",
"6lpy",
"6lq0",
"6lq1",
"6lq2",
"6lq3",
"6lq4",
"6lq5",
"6lq6",
"6lq7",
"6lq8",
"8png",
"8pns",
"8pu5",
"8r1e"
] | 21 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
16,
23857,
168,
431
] | 4 | [] | [] | 0 | true | Family | Diverse substrate specificity acyl-CoA dehydrogenase | Diverse substrate specificity acyl-CoA dehydrogenase | Diverse_Acyl-CoA_DH | 1 |
IPR052168 | 52,168 | Cytochrome b561 superoxide oxidase | Cytochrome_b561_oxidase | Family | 19,887 | true | false | This family of proteins includes B-type di-heme cytochromes that are involved in the redox reactions of cellular respiration. They catalyze the oxidation of superoxide to molecular oxygen, playing a role in the detoxification of reactive oxygen species. Additionally, they transfer electrons to quinones such as ubiquino... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30529"
] | [
"Cytochrome_b561_oxidase"
] | [
19887
] | 1 | [] | [] | [] | 0 | [
"5oc0"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctGBP5",
"unclassified sequences"
] | [
19629,
114,
1,
143
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Cytochrome b561 superoxide oxidase | Cytochrome b561 superoxide oxidase | Cytochrome_b561_oxidase | 5 |
IPR052169 | 52,169 | Cell Wall Biosynthesis Accessory Protein | CW_Biosynth-Accessory | Family | 15,548 | true | false | This family of proteins appears to be primarily involved in the biosynthesis, transport, or localization of cell wall components, which may include poly-alpha-L-glutamine (PLG) or gamma-polyglutamic acid (PGA). These components are significant for the structural integrity of the cell wall and may contribute to stress t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33393"
] | [
"CW_Biosynth-Accessory"
] | [
15548
] | 1 | [] | [] | [] | 0 | [
"8gq9",
"8gqa",
"8gqb",
"8itg",
"8ith"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
326,
14470,
487,
15,
250
] | 5 | [] | [] | 0 | true | Family | Cell Wall Biosynthesis Accessory Protein | Cell Wall Biosynthesis Accessory Protein | CW_Biosynth-Accessory | 6 |
IPR052170 | 52,170 | Metal-dependent Exopeptidase M29 | M29_Exopeptidase | Family | 14,651 | true | false | This family of proteins includes metal-dependent exopeptidases that cleave amino acids from the N-terminus of peptides. Members of this family exhibit broad specificity towards various N-terminal amino acids, including arginine and aromatic residues. Some proteins within this family are involved in bacterial growth by ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34448"
] | [
"M29_Exopeptidase"
] | [
14651
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.4.11.-",
"PWY-6423",
"PWY-7694",
"PWY-7954"
] | [
"EC:3.4.11.-",
"METACYC:PWY-6423",
"METACYC:PWY-7694",
"METACYC:PWY-7954"
] | 4 | [
"1zjc",
"2ayi",
"4icq",
"4icr",
"4ics",
"7cn3",
"7cnt",
"7cup"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ct3es5",
"unclassified sequences"
] | [
1357,
12979,
15,
1,
299
] | 5 | [] | [] | 0 | true | Family | Metal-dependent Exopeptidase M29 | Metal-dependent Exopeptidase M29 | M29_Exopeptidase | 3 |
IPR052171 | 52,171 | Non-homologous end joining protein LigD | NHEJ_LigD | Family | 18,124 | true | false | The LigD protein family is involved in non-homologous end joining (NHEJ), a DNA repair mechanism that fixes double-strand breaks with varying fidelity. Members of the LigD family possess multiple functional domains, including a polymerase/primase domain that prefers ribonucleotides over deoxynucleotides, which may be b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42705"
] | [
"NHEJ_LigD"
] | [
18124
] | 1 | [
"EC"
] | [
"6.5.1.1"
] | [
"EC:6.5.1.1"
] | 1 | [
"2fao",
"2faq",
"2far",
"2iru",
"2irx",
"2iry",
"2r9l",
"3pky",
"4mky",
"5dmu",
"5op0",
"6sa0",
"6sa1"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
14,
18029,
15,
66
] | 4 | [] | [] | 0 | true | Family | Non-homologous end joining protein LigD | Non-homologous end joining protein LigD | NHEJ_LigD | 7 |
IPR052172 | 52,172 | UxaA family altronate/galactarate dehydratases | UxaA_altronate/galactarate_dh | Family | 16,751 | true | false | The UxaA family encompasses enzymes that catalyze various dehydration reactions in bacterial metabolism. Members of the UxaA family are involved in the dehydration of D-altronate and galactarate, yielding their respective dehydrated products. Some UxaA family proteins function in concert with other subunits, such as th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30536"
] | [
"UxaA_altronate/galactarate_dh"
] | [
16751
] | 1 | [] | [] | [] | 0 | [
"3k3s",
"3laz",
"6u7l"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
319,
16061,
53,
318
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | UxaA family altronate/galactarate dehydratases | UxaA family altronate/galactarate dehydratases | UxaA_altronate/galactarate_dh | 6 |
IPR052173 | 52,173 | Beta-lactam antibiotic response regulator | Beta-lactam_resp_regulator | Family | 19,456 | true | false | This family of proteins includes members that are involved in the response to antibiotic stress, particularly beta-lactam antibiotics. They function as penicillin-interactive proteins and have a potential role as antirepressors. These proteins are integral membrane proteins that can sense the presence of beta-lactam an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34978"
] | [
"Beta-lactam_resp_regulator"
] | [
19456
] | 1 | [] | [] | [] | 0 | [
"8exp",
"8exq",
"8exr",
"8exs",
"8ext"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"unclassified Caudoviricetes"
] | [
5,
19315,
11,
123,
2
] | 5 | [] | [] | 0 | true | Family | Beta-lactam antibiotic response regulator | Beta-lactam antibiotic response regulator | Beta-lactam_resp_regulator | 3 |
IPR052174 | 52,174 | Flavoredoxin | Flavoredoxin | Family | 12,275 | true | false | The flavoredoxin family comprises proteins that are involved in the reduction of hydrogensulfite to hydrogen. Flavoredoxins contain a flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD) as a prosthetic group, which is essential for their redox activity. These proteins play a role in various cellular proces... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43567"
] | [
"Flavoredoxin"
] | [
12275
] | 1 | [] | [] | [] | 0 | [
"1usc",
"1usf",
"2d5m",
"2r6v",
"3bnk",
"3e4v",
"3hmz",
"3zoc",
"3zod",
"3zoe",
"3zof",
"3zog",
"3zoh"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
424,
11141,
434,
276
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flavoredoxin | Flavoredoxin | Flavoredoxin | 8 |
IPR052175 | 52,175 | Complex I-like Hydrogenase Component | ComplexI-like_HydComp | Family | 9,555 | true | false | This family of proteins includes components that are potentially involved in the formation of hydrogenase complexes, specifically hydrogenase 4 in bacteria such as E. coli. These proteins are homologous to subunits of complex I, which is a large enzyme complex involved in the electron transport chain and energy metabol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42682"
] | [
"ComplexI-like_HydComp"
] | [
9555
] | 1 | [] | [] | [] | 0 | [
"7tgh",
"7z0s",
"7z0t",
"8b6f",
"8bqs",
"8gym",
"8gzu"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
891,
8250,
48,
366
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Complex I-like Hydrogenase Component | Complex I-like Hydrogenase Component | ComplexI-like_HydComp | 7 |
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