LiteFold/InterPro · Datasets at Hugging Face

IPR053106

53,106

Plant Male Germline-Regulatory Transcription Factors

Plant_Male-Germline_Reg_TFs

Family

879

true

false

This family of proteins includes transcription factors that play a crucial role in plant development and reproduction. Members of this family are involved in the regulation of gene expression by binding to specific DNA sequences. They function as activators of transcription, promoting the expression of genes that are e...

[]

0

[ "PANTHER" ]

[ "PTHR47996" ]

[ "Plant_Male-Germline_Reg_TFs" ]

[ 879 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 879 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 2, 9 ]

3

true

Family

Plant Male Germline-Regulatory Transcription Factors

Plant_Male-Germline_Reg_TFs

2

IPR053107

53,107

TNF receptor superfamily member 18

TNFRSF18

Family

600

true

false

This family of proteins includes receptors that bind to TNFSF18, a ligand involved in the regulation of immune responses. Members are implicated in the interaction between activated T-lymphocytes and endothelial cells, playing a role in the modulation of T-cell receptor-mediated apoptosis. They are also known to activa...

[]

0

[ "PANTHER" ]

[ "PTHR47388" ]

[ "TNFRSF18" ]

[ 600 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5669034", "R-HSA-8877330", "R-MMU-5669034" ]

[ "REACTOME:R-HSA-5669034", "REACTOME:R-HSA-8877330", "REACTOME:R-MMU-5669034" ]

3

[ "7e57", "7khd", "7khx", "7law", "7rfp" ]

5

[]

0

[]

0

null

[ "Euteleostomi" ]

[ 600 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 4, 6 ]

4

true

Family

TNF receptor superfamily member 18

TNFRSF18

8

IPR053108

53,108

Chlamydial Translocated Actin-Recruiting Phosphoprotein

Chlamydial_TARP

Family

635

true

false

The chlamydial CPn_0572/CT_456/TC_0741 family includes proteins that are involved in signaling events related to actin recruitment. Members of the family appear to play a role in initiating or participating in the cellular processes that lead to the internalization of the pathogen into host cells. The actin recruitment...

[]

0

[ "PANTHER" ]

[ "PTHR36975" ]

[ "Chlamydial_TARP" ]

[ 635 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Bodo saltans virus", "Eukaryota", "metagenomes" ]

[ 54, 217, 1, 360, 3 ]

5

[]

0

true

Family

Chlamydial Translocated Actin-Recruiting Phosphoprotein

Chlamydial_TARP

6

IPR053109

53,109

Serine/Threonine-Protein Kinase-Related

Ser/Thr-Kinase-Related

Family

188

true

false

This family of proteins includes serine/threonine kinases, which are typically involved in phosphorylating serine or threonine residues in substrate proteins, playing critical roles in various cellular processes such as signal transduction, cell division, and metabolism. Although one member of this family is predicted ...

[]

0

[ "PANTHER" ]

[ "PTHR31534" ]

[ "Ser/Thr-Kinase-Related" ]

[ 188 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 173, 15 ]

2

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 12, 1 ]

2

true

Family

Serine/Threonine-Protein Kinase-Related

Ser/Thr-Kinase-Related

2

IPR053110

53,110

Ribosomal L1 domain-containing protein and Transcription factor

Ribosomal_L1-TF

Family

364

true

false

This family of proteins includes members that are involved in distinct cellular processes. One protein is implicated in the structure and function of ribosomes, specifically within the ribosomal L1 domain, suggesting a role in the translation machinery. Another member functions as a transcription factor, acting as a ne...

[]

0

[ "PANTHER" ]

[ "PTHR48162" ]

[ "Ribosomal_L1-TF" ]

[ 364 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 13, 348, 3 ]

3

[ "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2, 1 ]

2

true

Family

Ribosomal L1 domain-containing protein and Transcription factor

Ribosomal_L1-TF

7

IPR053111

53,111

Chloroplastic FKBP-type Peptidyl-prolyl cis-trans Isomerase

Chloro_FKBP-type_PPIase

Family

739

true

false

The FKBP-type PPIase family comprises proteins that function as peptidyl-prolyl cis-trans isomerases (PPIases), which are enzymes that accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. These proteins are typically involved in protein folding p...

[]

0

[ "PANTHER" ]

[ "PTHR47598" ]

[ "Chloro_FKBP-type_PPIase" ]

[ 739 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 7, 732 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 4, 10 ]

3

true

Family

Chloroplastic FKBP-type Peptidyl-prolyl cis-trans Isomerase

Chloro_FKBP-type_PPIase

8

IPR053112

53,112

Fungal Dehydratase/Hydratase

Fungal_Dehydratase/Hydratase

Family

582

true

false

This family of proteins includes enzymes involved in diverse biosynthetic and protective pathways in fungi. Members of this family function as dehydratases and hydratases, catalyzing the addition or removal of water from specific substrates. One member is involved in the biosynthesis of aspoquinolone mycotoxins, partic...

[]

0

[ "PANTHER" ]

[ "PTHR40617" ]

[ "Fungal_Dehydratase/Hydratase" ]

[ 582 ]

1

[]

0

[ "7a0q", "7a0t" ]

2

[]

0

[]

0

null

[ "Bacteria", "Fungi" ]

[ 78, 504 ]

2

[]

0

true

Family

Fungal Dehydratase/Hydratase

Fungal_Dehydratase/Hydratase

8

IPR053113

53,113

IQ domain-containing protein

IQ_domain_protein

Family

556

true

false

This family of proteins contains the IQ domain, which is known to be involved in calcium-independent calmodulin-binding. Members of this family are characterized by the presence of this domain, suggesting a role in signal transduction pathways. The IQ motif is typically found in proteins that interact with calmodulin a...

[]

0

[ "PANTHER" ]

[ "PTHR35976" ]

[ "IQ_domain_protein" ]

[ 556 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 556 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 3 ]

3

true

Family

IQ domain-containing protein

IQ_domain_protein

6

IPR053114

53,114

Histone-lysine N-methyltransferase ATXR5/ATXR6

ATXR5/ATXR6

Family

1,397

false

This family of proteins includes histone-lysine N-methyltransferases that are responsible for the monomethylation of 'Lys-27' on histone H3 (H3K27me1). These enzymes exhibit a preference for nucleosomes containing the H3.1 variant over H3.3 [ ]. They play a crucial role in the establishment of constitutive heterochroma...

[]

0

[ "PANTHER", "PANTHER" ]

[ "PTHR48442", "PTHR48458" ]

[ "", "" ]

[ 942, 455 ]

2

[ "EC" ]

[ "2.1.1.369" ]

[ "EC:2.1.1.369" ]

1

[ "4o30", "5va6", "5vac", "5vah", "5vbc" ]

5

[ "PUB00149326", "PUB00149327", "PUB00149328", "PUB00149329", "PUB00155251" ]

[ "16771839", "19503079", "20631708", "22549957", "35298257" ]

[ "Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.", "ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.", "Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferas...

[ 2006, 2009, 2010, 2012, 2022 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1397 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 6, 8 ]

3

true

Family

Histone-lysine N-methyltransferase ATXR5/ATXR6

ATXR5/ATXR6

3

IPR053115

53,115

Cyclin-dependent kinase inhibitor

CDK_inhibitor

Family

639

true

false

This family of proteins includes cyclin-dependent kinase (CDK) inhibitors that are likely involved in the regulation of the cell cycle. Specifically, they are thought to act as repressors of mitosis during the endoreduplication cell cycle, a variant of the normal cell cycle that involves DNA replication without subsequ...

[]

0

[ "PANTHER" ]

[ "PTHR35162" ]

[ "CDK_inhibitor" ]

[ 639 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spermatophyta" ]

[ 639 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 11, 27 ]

3

true

Family

Cyclin-dependent kinase inhibitor

CDK_inhibitor

9

IPR053116

53,116

GATA-type Zinc Finger Regulator

GATA-type_Znf_Regulator

Family

566

true

This family of proteins includes transcriptional regulators that are crucial for germ cell development. They are involved in determining the oogenic fate by activating essential genes for the initiation of the oogenic program and the entry into meiotic prophase. These proteins function downstream of bone morphogenetic ...

[]

0

[ "PANTHER" ]

[ "PTHR47341" ]

[ "GATA-type_ZnF_Regulator" ]

[ 566 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 566 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 1, 2 ]

4

true

Family

GATA-type Zinc Finger Regulator

GATA-type_Znf_Regulator

5

IPR053117

53,117

Distal Membrane-arm Assembly Complex Protein

DMAC_Protein

Family

477

true

false

This family of proteins is involved in the mitochondrial respiratory chain, specifically in the assembly of complex I, also known as NADH:ubiquinone oxidoreductase. Members of this family play a crucial role in the formation of the distal membrane arm of complex I, which is essential for the proper function and structu...

[]

0

[ "PANTHER" ]

[ "PTHR36469" ]

[ "DMAC_Protein" ]

[ 477 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6799198", "R-MMU-6799198" ]

[ "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198" ]

2

[]

0

[]

0

[]

0

null

[ "Chordata" ]

[ 477 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 4 ]

4

true

Family

Distal Membrane-arm Assembly Complex Protein

DMAC_Protein

6

IPR053119

53,119

Cubilin domain-containing protein

Cubilin_domain

Family

215

true

false

This family of proteins functions as endocytic receptors involved in the uptake of various substances including lipoproteins, vitamins, and iron, playing a critical role in their metabolism. They form a complex structure with a long stem and a globular crown, which is essential for their interaction with a range of lig...

[]

0

[ "PANTHER" ]

[ "PTHR47761" ]

[ "Cubilin_domain" ]

[ 215 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 215 ]

1

[ "Caenorhabditis elegans", "Homo sapiens" ]

[ 4, 2 ]

2

true

Family

Cubilin domain-containing protein

Cubilin_domain

3

IPR053120

53,120

Paraflagellar Rod Component

PFR_Component

Family

405

true

false

This family of proteins includes components of the paraflagellar rod (PFR), which is a structure found within the flagellum of certain eukaryotic cells. The PFR is composed of highly ordered lattices of fibrous proteins that are oriented in a fixed manner relative to the microtubular axoneme of the flagellum. These pro...

[]

0

[ "PANTHER" ]

[ "PTHR34732" ]

[ "PFR_Component" ]

[ 405 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 405 ]

1

[]

0

true

Family

Paraflagellar Rod Component

PFR_Component

7

IPR053121

53,121

Spore Coat Assembly Protein

Spore_Coat_Assembly

Family

487

true

false

This family of proteins is involved in the formation of protective structures during the developmental stage of spore formation. Members of this family play a role in the assembly of the spore coat, which is crucial for spore viability and resistance. They interact with other components such as cellulose and specific p...

[]

0

[ "PANTHER" ]

[ "PTHR35365" ]

[ "Spore_Coat_Assembly" ]

[ 487 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati" ]

[ 27, 458, 2 ]

3

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Family

Spore Coat Assembly Protein

Spore_Coat_Assembly

7

IPR053122

53,122

RING finger domain-containing protein

RING_finger_domain

Family

445

true

false

This family of proteins includes members that contain a RING finger domain, a specialized type of zinc finger that binds two zinc ions. This domain is involved in mediating protein-protein interactions and is commonly found in E3 ubiquitin-protein ligases, which play a critical role in the ubiquitination pathway. Ubiqu...

[]

0

[ "PANTHER" ]

[ "PTHR47454" ]

[ "RING_finger_domain" ]

[ 445 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 445 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 1, 1, 2 ]

4

true

Family

RING finger domain-containing protein

RING_finger_domain

4

IPR053123

53,123

Chondroitin Proteoglycan 4-like

CPG4-like

Family

331

true

false

This family of proteins includes chondroitin proteoglycan 4, which is involved in the formation of proteoglycan aggregates that contribute to the extracellular matrix structure. These proteins play a role in cell adhesion, migration, and proliferation. They are part of the larger group of chondroitin sulfate proteoglyc...

[]

0

[ "PANTHER" ]

[ "PTHR37442" ]

[ "CPG4-like" ]

[ 331 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 331 ]

1

[ "Caenorhabditis elegans" ]

[ 2 ]

1

true

Family

Chondroitin Proteoglycan 4-like

CPG4-like

9

IPR053124

53,124

Notch pathway signaling modulators

Notch_signaling_modulators

Family

341

true

false

This family of proteins includes secreted factors that are likely involved in Notch signaling pathways. Members of this family are implicated in determining cell fate decisions, particularly in vulval precursor cells, by acting redundantly with other ligands. They are also associated with neuronal functions, contributi...

[]

0

[ "PANTHER" ]

[ "PTHR35015" ]

[ "Notch_signaling_modulators" ]

[ 341 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 341 ]

1

[ "Caenorhabditis elegans" ]

[ 5 ]

1

true

Family

Notch pathway signaling modulators

Notch_signaling_modulators

7

IPR053125

53,125

RNA-binding mRNA stabilization regulator

RNA-bd_mRNA_stabilization_reg

Family

308

true

false

This family of proteins is involved in the post-transcriptional regulation of mRNA stability. Members of this family function by binding to specific mRNA transcripts and enhancing their stability. They achieve this by interacting with other proteins such as MKT1 and PBP1, which are implicated in the stabilization proce...

[]

0

[ "PANTHER" ]

[ "PTHR37035" ]

[ "RNA-bd_mRNA_stabilization_reg" ]

[ 308 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Euglenozoa" ]

[ 308 ]

1

[]

0

true

Family

RNA-binding mRNA stabilization regulator

RNA-bd_mRNA_stabilization_reg

1

IPR053127

53,127

Chromatin remodeling complex subunit

Chromatin_remod_comp_subunit

Family

450

true

false

This family of proteins includes components of ATP-dependent chromatin remodeling complexes, which are pivotal in both the activation and repression of gene expression. Members of this family are involved in modifying chromatin structure by altering DNA-histone contacts within nucleosomes. These changes can lead to shi...

[]

0

[ "PANTHER" ]

[ "PTHR37929" ]

[ "Chromatin_remod_comp_subunit" ]

[ 450 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 4, 446 ]

2

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Family

Chromatin remodeling complex subunit

Chromatin_remod_comp_subunit

7

IPR053128

53,128

Cystatin-like inhibitors

Cystatin-like

Family

254

true

false

This family of proteins includes inhibitors of cysteine proteinases. Members of this family are known to selectively inhibit the activity of specific proteinases, thereby playing a role in protecting tissues from proteolytic damage during various stages of development. The proteins within this family are characterized ...

[]

0

[ "PANTHER" ]

[ "PTHR12319" ]

[ "Cystatin-like" ]

[ 254 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Uabimicrobium amorphum" ]

[ 253, 1 ]

2

[ "Drosophila melanogaster" ]

[ 5 ]

1

true

Family

Cystatin-like inhibitors

Cystatin-like

9

IPR053129

53,129

Integrator complex-associated protein

Integrator_complex_assoc

Family

180

true

false

This family of proteins includes members that are potentially involved in the transcription and processing of small nuclear RNAs (snRNAs), specifically U1 and U2. These proteins may be part of the Integrator complex, which plays a role in snRNA 3'-box-dependent processing. The family also encompasses proteins that are ...

[]

0

[ "PANTHER" ]

[ "PTHR48194" ]

[ "Integrator_complex_assoc" ]

[ 180 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 177 ]

2

[]

0

true

Family

Integrator complex-associated protein

Integrator_complex_assoc

2

IPR053130

53,130

ARL14 effector protein-like

ARL14_effector

Family

95

true

false

This family of proteins includes members that are likely involved in intracellular signaling pathways. They are characterized by their association with the small GTPase ARL14, suggesting a role in modulating the activity of this GTPase. Proteins in this family may participate in the regulation of immune responses, as A...

[]

0

[ "PANTHER" ]

[ "PTHR46804" ]

[ "ARL14_effector" ]

[ 95 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 95 ]

1

[ "Homo sapiens", "Rattus norvegicus" ]

[ 1, 1 ]

2

true

Family

ARL14 effector protein-like

ARL14_effector

5

IPR053132

53,132

Mesendoderm Development Regulator

Mesendoderm_Regulator

Family

96

true

false

This family of proteins is implicated in the development of the mesendoderm, a germ layer formed during the embryogenesis of some animals. Members of this family are believed to be involved in the regulatory processes that govern the differentiation and development of this layer, which gives rise to both mesodermal and...

[]

0

[ "PANTHER" ]

[ "PTHR35855" ]

[ "Mesendoderm_Regulator" ]

[ 96 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 96 ]

1

[ "Caenorhabditis elegans" ]

[ 7 ]

1

true

Family

Mesendoderm Development Regulator

Mesendoderm_Regulator

3

IPR053133

53,133

Sexual cell fusion glycoprotein

Sexual_fusion_gp

Family

54

true

false

This family of proteins is involved in the process of sexual cell fusion in the slime mold Dictyostelium discoideum. Members of this family are cell surface glycoproteins that play a crucial role during the sexual phase of the organism's life cycle by mediating cell-to-cell fusion events. These proteins are essential f...

[]

0

[ "PANTHER" ]

[ "PTHR31093" ]

[ "Sexual_fusion_gp" ]

[ 54 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dictyostelia" ]

[ 54 ]

1

[]

0

true

Family

Sexual cell fusion glycoprotein

Sexual_fusion_gp

5

IPR053134

53,134

RNA-directed DNA polymerase homolog

RNA-dir_DNA_polymerase

Family

45,367

true

false

This family of proteins includes enzymes that are responsible for the synthesis of DNA from an RNA template. They are typically found in retroviruses and are essential for the viral replication process. These enzymes exhibit reverse transcriptase activity, which involves the transcription of the viral RNA genome into D...

[]

0

[ "PANTHER" ]

[ "PTHR24559" ]

[ "RNA-dir_DNA_polymerase" ]

[ 45367 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Riboviria", "metagenomes" ]

[ 53, 45267, 44, 3 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 2, 1, 187, 4 ]

5

true

Family

RNA-directed DNA polymerase homolog

RNA-dir_DNA_polymerase

3

IPR053135

53,135

Aldo-Keto Reductase 2 Subfamily Oxidoreductase

AKR2_Oxidoreductase

Family

22,581

true

false

This family of proteins includes enzymes that are part of the aldo/keto reductase superfamily. These enzymes are involved in the reduction of aldehydes and ketones into their corresponding alcohols. They play a role in various metabolic processes, including the detoxification of aldehydes and the metabolism of sugars, ...

[]

0

[ "PANTHER" ]

[ "PTHR43312" ]

[ "AKR2_Oxidoreductase" ]

[ 22581 ]

1

[]

0

[ "1ynp", "1ynq", "4exa", "4exb" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ct7es18", "unclassified sequences" ]

[ 1512, 20184, 315, 1, 569 ]

5

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Aldo-Keto Reductase 2 Subfamily Oxidoreductase

AKR2_Oxidoreductase

6

IPR053136

53,136

UTP pyrophosphatase-like

UTP_pyrophosphatase-like

Family

22,088

true

false

This family of proteins is involved in nucleotide metabolism, specifically catalyzing the hydrolysis of UTP to UMP and diphosphate. The enzymatic activity is highly specific to UTP and does not extend to other nucleoside triphosphates such as ATP, GTP, CTP, dTTP, or ITP. The reaction is a part of the pyrimidine salvage...

[]

0

[ "PANTHER" ]

[ "PTHR30399" ]

[ "UTP_pyrophosphatase-like" ]

[ 22088 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctWXg38", "unclassified sequences" ]

[ 467, 20823, 369, 1, 428 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Family

UTP pyrophosphatase-like

UTP_pyrophosphatase-like

4

IPR053137

53,137

Nucleotide-binding leucine-rich repeat (NLR)-like

NLR-like

Family

33,713

true

This family of proteins includes members with a multi-domain architecture that is involved in nucleotide binding and hydrolysis. Nucleotide-binding leucine-rich repeat (NLR)-like protein from Hyaloscypha variabilis contains a purine nucleoside phosphorylase (PNP) domain at the N-terminal that cleaves the N-glycosidic b...

[]

0

[ "PANTHER" ]

[ "PTHR46082" ]

[ "NB-ARC_NLR-like" ]

[ 33713 ]

1

[]

0

[ "4y6c" ]

1

[ "PUB00156057" ]

[ "37595565" ]

[ "A conserved family of immune effectors cleaves cellular ATP upon viral infection." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 6943, 26751, 7, 12 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 5 ]

1

true

Family

Nucleotide-binding leucine-rich repeat (NLR)-like

NLR-like

4

IPR053138

53,138

N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase

N-alpha-Ac-DABA_deacetylase

Family

14,326

true

false

This family of proteins is involved in the degradation of ectoine, a compatible solute that microorganisms use under stress conditions such as high salinity. Members of this family are responsible for the deacetylation step in the ectoine degradation pathway. Specifically, they catalyze the conversion of N-alpha-acetyl...

[]

0

[ "PANTHER" ]

[ "PTHR37326" ]

[ "N-alpha-Ac-DABA_deacetylase" ]

[ 14326 ]

1

[]

0

[ "2qj8", "3cdx", "3fmc", "3lwu", "3na6", "6twl", "6twm", "8ein", "8eip" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1352, 12403, 391, 2, 178 ]

5

[]

0

true

Family

N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase

N-alpha-Ac-DABA_deacetylase

4

IPR053139

53,139

Putative surface bspA-like protein

Surface_bspA-like

Family

13,696

true

false

This family of proteins is implicated in interactions with host tissues. The members of this family may have a role in adherence or invasion processes during the infection cycle, potentially by binding to host cell surfaces or extracellular matrix components. The exact molecular mechanisms and the specific host tissues...

[]

0

[ "PANTHER" ]

[ "PTHR45661" ]

[ "Surface_bspA-like" ]

[ 13696 ]

1

[]

0

[ "4cp6", "4fd0", "4fdw", "4fs7", "4gt6", "4h09", "4oju", "6mlx" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 6691, 6718, 41, 29, 217 ]

5

[]

0

true

Family

Putative surface bspA-like protein

Surface_bspA-like

8

IPR053141

53,141

Mycobacterial serine protease inhibitor Rv3364c

Mycobact_SerProt_Inhib_Rv3364c

Family

17,540

true

false

This family of proteins includes effectors that interact with host serine proteases such as cathepsin G, located on macrophage cell membranes. They play a role in modulating the host's immune response by inhibiting the enzymatic activity of these proteases. Inhibition of cathepsin G prevents the activation of caspase-1...

[]

0

[ "PANTHER" ]

[ "PTHR36222" ]

[ "Mycobact_SerProt_Inhib_Rv3364c" ]

[ 17540 ]

1

[ "REACTOME" ]

[ "R-HSA-9635465" ]

[ "REACTOME:R-HSA-9635465" ]

1

[ "3kye", "3leq", "7f8m" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 55, 17453, 32 ]

3

[]

0

true

Family

Mycobacterial serine protease inhibitor Rv3364c

Mycobact_SerProt_Inhib_Rv3364c

8

IPR053142

53,142

Pyochelin receptor regulatory protein

PchR_regulatory_protein

Family

14,192

true

false

This family of proteins includes transcriptional activators that are involved in the regulation of siderophore-mediated iron acquisition systems. Members of this family function as positive regulators, enhancing the expression of genes related to the synthesis and transport of pyochelin, a siderophore that chelates iro...

[]

0

[ "PANTHER" ]

[ "PTHR47893" ]

[ "PchR_regulatory_protein" ]

[ 14192 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 23, 14051, 9, 109 ]

4

[]

0

true

Family

Pyochelin receptor regulatory protein

PchR_regulatory_protein

3

IPR053144

53,144

Putative Acetyltransferase Butenolide Biosynthesis

Acetyltransferase_Butenolide

Family

11,749

true

false

This family of proteins includes putative acetyltransferases that are implicated in the biosynthesis of secondary metabolites such as butenolide, a compound with antibiotic properties. These proteins are predicted to contribute to the formation of a 4-acetamido-2-butenoic acid intermediate from glutamic acid. The exact...

[]

0

[ "PANTHER" ]

[ "PTHR43233" ]

[ "Acetyltransferase_Butenolide" ]

[ 11749 ]

1

[]

0

[ "1y7r", "2ozh" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 147, 10054, 1497, 51 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Putative Acetyltransferase Butenolide Biosynthesis

Acetyltransferase_Butenolide

2

IPR053145

53,145

AB hydrolase superfamily Esterase 10

AB_hydrolase_Est10

Family

13,650

true

false

This family of proteins exhibits esterase activity, preferentially hydrolyzing short acyl chain esters ranging from C4 to C8. The precise physiological role of these proteins remains unclear. They do not display protease or peptidase activity when tested with common substrates. Members of this family are characterized ...

[]

0

[ "PANTHER" ]

[ "PTHR43265" ]

[ "AB_hydrolase_Est10" ]

[ 13650 ]

1

[]

0

[ "3pf8", "3pf9", "3pfb", "3pfc", "3qm1", "3s2z", "7q4h", "7q4j", "7wwh", "7xrh", "7xri", "7z2u", "7z2v", "7z2x", "8b9s", "8skm", "8slj", "9h0z" ]

18

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 211, 13184, 135, 120 ]

4

[]

0

true

Family

AB hydrolase superfamily Esterase 10

AB_hydrolase_Est10

4

IPR053146

53,146

Quercetin 2,3-dioxygenase-like

QDO-like

Family

12,607

true

false

This family of proteins is involved in the metabolic breakdown of flavonoids, specifically quercetin. Members of this family are responsible for catalyzing the dioxygenolytic cleavage of the O-heteroaromatic ring in quercetin, leading to the formation of 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monox...

[]

0

[ "PANTHER" ]

[ "PTHR36440" ]

[ "QDO-like" ]

[ 12607 ]

1

[]

0

[ "1y3t", "2h0v", "3ht1", "3ht2", "5flh", "5fli", "5flj", "8hfb" ]

8

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 438, 10586, 1548, 35 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Quercetin 2,3-dioxygenase-like

QDO-like

7

IPR053147

53,147

Heat shock protein HslJ-like

Hsp_HslJ-like

Family

12,121

true

false

This family of proteins includes molecular chaperones that are implicated in the response to environmental stress, such as elevated temperatures. They are involved in the folding and unfolding of other proteins, as well as in the assembly and disassembly of protein complexes. These proteins may also play a role in the ...

[]

0

[ "PANTHER" ]

[ "PTHR35535" ]

[ "Hsp_HslJ-like" ]

[ 12121 ]

1

[]

0

[ "2kts", "2la7" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 11918, 12, 110, 81 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Heat shock protein HslJ-like

Hsp_HslJ-like

7

IPR053148

53,148

PD-(D/E)XK-like domain-containing protein

PD-DEXK-like_domain

Family

9,969

true

false

This family of proteins includes putative nucleases that may play a role in DNA recombination and repair processes. Members are characterized by the presence of a PD-(D/E)XK-like nuclease domain, which suggests they have the ability to interact with and cleave nucleic acid substrates.

[]

0

[ "PANTHER" ]

[ "PTHR30547" ]

[ "PD-DEXK-like_domain" ]

[ 9969 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 165, 9551, 22, 4, 227 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

PD-(D/E)XK-like domain-containing protein

PD-DEXK-like_domain

9

IPR053149

53,149

Thiamine pyrophosphokinase

TPK

Family

8,869

true

false

This family of proteins is involved in the biosynthesis of thiamine pyrophosphate, an essential coenzyme required by all living organisms. Members of this family are responsible for the phosphorylation of thiamine (vitamin B1) to produce thiamine pyrophosphate. This conversion is a critical step in the utilization of t...

[]

0

[ "PANTHER" ]

[ "PTHR41299" ]

[ "TPK" ]

[ 8869 ]

1

[]

0

[ "2omk", "3cq9", "3ihk", "3k94", "3l8m", "3lm8", "3mel" ]

7

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 33, 8651, 16, 169 ]

4

[]

0

true

Family

Thiamine pyrophosphokinase

TPK

3

IPR053150

53,150

Teicoplanin resistance-associated protein

Teicoplanin_resist-assoc

Family

11,876

true

false

This family of proteins is associated with a specific function related to antibiotic resistance. Members of this family have been implicated in providing low-level resistance to the glycopeptide antibiotic teicoplanin. The mechanism by which this resistance is conferred is not fully understood, but it is believed that ...

[]

0

[ "PANTHER" ]

[ "PTHR36834" ]

[ "Teicoplanin_resist-assoc" ]

[ 11876 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 11839, 37 ]

2

[]

0

true

Family

Teicoplanin resistance-associated protein

Teicoplanin_resist-assoc

7

IPR053151

53,151

Ribonuclease H-like

RNase_H-like

Family

21,166

true

false

This family of proteins includes enzymes that are putative ribonucleases H (RNases H), which are known to catalyze the hydrolysis of RNA in RNA/DNA hybrids. These proteins play a crucial role in DNA replication, repair, and recombination by removing RNA primers from Okazaki fragments and during the process of retrovira...

[]

0

[ "PANTHER" ]

[ "PTHR47723" ]

[ "RNase_H-like" ]

[ 21166 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 35, 1181, 19857, 59, 34 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 50, 61, 3 ]

3

true

Family

Ribonuclease H-like

RNase_H-like

3

IPR053152

53,152

Probable Hydrolase YcaC-like

Hydrolase_YcaC-like

Family

11,738

true

false

This family of proteins includes enzymes that are likely to function as hydrolases. Hydrolases are a broad class of enzymes that catalyze the hydrolytic cleavage of chemical bonds, such as ester, glycosidic, peptide, and other bonds. The specific substrates and reactions catalyzed by this family are not detailed in the...

[]

0

[ "PANTHER" ]

[ "PTHR43559" ]

[ "Hydrolase_YcaC-like" ]

[ 11738 ]

1

[]

0

[ "1yac", "4wgf", "4wh0" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 10330, 1355, 30, 23 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 1, 1 ]

2

true

Family

Probable Hydrolase YcaC-like

Hydrolase_YcaC-like

9

IPR053154

53,154

Cyclic di-AMP regulator

c-di-AMP_regulator

Family

7,547

true

false

This family of proteins enhances the enzymatic activity of diadenylate cyclases upon coexpression. Specifically, they can stimulate the production of cyclic di-AMP, a molecule that serves as a second messenger in various cellular processes including growth, DNA repair, and cell wall maintenance. However, an overabundan...

[]

0

[ "PANTHER" ]

[ "PTHR37804" ]

[ "c-di-AMP_regulator" ]

[ 7547 ]

1

[]

0

[ "2kq1", "2kxy", "4qdy", "5hqh" ]

4

[]

0

[]

0

null

[ "Bacteria", "Potamilus streckersoni", "unclassified sequences" ]

[ 7450, 1, 96 ]

3

[]

0

true

Family

Cyclic di-AMP regulator

c-di-AMP_regulator

1

IPR053155

53,155

F-pilin assembly protein TraC

F-pilin_assembly_TraC

Family

7,642

true

false

This family of proteins is involved in the formation of bacterial appendages known as F pili. Members of this family play a crucial role in the assembly process by facilitating the incorporation of mature F-pilin subunits into the structure of the pilus. These pili are filamentous projections on the bacterial surface t...

[]

0

[ "PANTHER" ]

[ "PTHR38467" ]

[ "F-pilin_assembly_TraC" ]

[ 7642 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences", "virus sp. ctLpa4" ]

[ 7485, 25, 2, 128, 2 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

F-pilin assembly protein TraC

F-pilin_assembly_TraC

6

IPR053157

53,157

Sterol Uptake Control Transcription Regulator

Sterol_Uptake_Regulator

Family

11,993

true

false

This family of proteins includes transcription factors that are key regulators of anaerobic gene expression, particularly for genes encoding cell wall mannoproteins. They are known to bind specific anaerobic response elements in the promoters of target genes. Additionally, these proteins play a crucial role in the upta...

[]

0

[ "PANTHER" ]

[ "PTHR47784" ]

[ "Sterol_Uptake_Regulator" ]

[ 11993 ]

1

[]

0

[ "4n9n", "7vpr", "7vpu", "7xb5" ]

4

[]

0

[]

0

null

[ "Eukaryota" ]

[ 11993 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 2 ]

2

true

Family

Sterol Uptake Control Transcription Regulator

Sterol_Uptake_Regulator

2

IPR053158

53,158

Type 1 Capsular Polysaccharide Biosynthesis Protein CapK

CapK_Type1_Caps_Biosynth

Family

6,453

true

false

The CapK protein family is involved in the biosynthesis of type 1 capsular polysaccharide. Capsular polysaccharides are critical components of the bacterial cell envelope, often contributing to pathogenicity and immune evasion by forming a protective layer around the cell. Members of the CapK family are essential enzym...

[]

0

[ "PANTHER" ]

[ "PTHR36932" ]

[ "CapK_Type1_Caps_Biosynth" ]

[ 6453 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]

[ 152, 6147, 7, 145, 2 ]

5

[]

0

true

Family

Type 1 Capsular Polysaccharide Biosynthesis Protein CapK

CapK_Type1_Caps_Biosynth

3

IPR053159

53,159

Hybrid Signal Transduction Histidine Kinase

Hybrid_Histidine_Kinase

Family

8,285

true

false

This family of proteins participates in signal transduction pathways as receptor histidine kinases. They are characterized by an ATP-dependent autophosphorylation on a conserved histidine residue within the kinase core. Following autophosphorylation, a phosphoryl group is transferred to a conserved aspartate residue in...

[]

0

[ "PANTHER" ]

[ "PTHR43642" ]

[ "Hybrid_Histidine_Kinase" ]

[ 8285 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 5532, 2733, 5, 15 ]

4

[]

0

true

Family

Hybrid Signal Transduction Histidine Kinase

Hybrid_Histidine_Kinase

4

IPR053160

53,160

Major Facilitator Superfamily DHA3 Transporter

MFS_DHA3_Transporter

Family

6,742

true

false

This family of proteins includes members that are part of the major facilitator superfamily (MFS), which are known to facilitate the transport of a variety of substrates across cellular membranes. Specifically, this family is associated with the Drug:H(+) antiporter-3 (DHA3) group within the MFS, indicating a role in t...

[]

0

[ "PANTHER" ]

[ "PTHR23530" ]

[ "MFS_DHA3_Transporter" ]

[ 6742 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 371, 6291, 13, 67 ]

4

[]

0

true

Family

Major Facilitator Superfamily DHA3 Transporter

MFS_DHA3_Transporter

8

IPR053161

53,161

Ulvan-degrading glycoside hydrolase

Ulvan_degrading_GH

Family

5,186

true

false

This family of proteins includes glycoside hydrolases that are implicated in the degradation of ulvan, a major polysaccharide found in the cell walls of green seaweed from the Ulvales order. Members of this family are characterized by their ability to cleave the glycosidic linkages within ulvan, which is composed of di...

[]

0

[ "PANTHER" ]

[ "PTHR36848" ]

[ "Ulvan_degrading_GH" ]

[ 5186 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 17, 3943, 1160, 66 ]

4

[]

0

true

Family

Ulvan-degrading glycoside hydrolase

Ulvan_degrading_GH

5

IPR053162

53,162

DnaD

Family

8,048

true

This entry represents DnaD proteins in bacteria. The DnaD protein is a component of the PriA primosome. The PriA primosome functions to recruit the replication fork helicase onto the DNA [ ]. Members, both chromosomal or phage-associated, are found in the Bacillus/Clostridium group of Gram-positive bacteria [ ]. DnaD c...

[]

0

[ "PANTHER" ]

[ "PTHR37293" ]

[ "DNA_Replication_Initiator" ]

[ 8048 ]

1

[]

0

[ "2i5u", "2zc2", "8ojj" ]

3

[ "PUB00009584", "PUB00085025" ]

[ "11679082", "16677303" ]

[ "DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome.", "The DNA-remodelling activity of DnaD is the sum of oligomerization and DNA-binding activities on separate domains." ]

[ 2001, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 7721, 3, 258, 66 ]

4

[]

0

true

Family

DnaD

6

IPR053164

53,164

IS1016-like transposase

IS1016-like_transposase

Family

8,101

true

false

This family of proteins includes transposase-like elements that are similar to the insertion element IS1016 transposase. Transposases are enzymes that catalyze the movement of transposable elements (TEs) within the genomes of bacteria and other organisms. These proteins play a key role in the mobility of TEs, enabling ...

[]

0

[ "PANTHER" ]

[ "PTHR47163" ]

[ "IS1016-like_transposase" ]

[ 8101 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 3018, 4977, 12, 93, 1 ]

5

[ "Danio rerio" ]

[ 10 ]

1

true

Family

IS1016-like transposase

IS1016-like_transposase

8

IPR053165

53,165

HSI-I assembly protein Hcp1

HSI-I_assembly_Hcp1

Family

7,114

true

false

This family of proteins is involved in the assembly of a protein secretion system known as HSI-I. Members of this family are actively secreted and play a role during chronic infections, such as those occurring in cystic fibrosis patients. They are essential components of the machinery required for the secretion of effe...

[]

0

[ "PANTHER" ]

[ "PTHR36152" ]

[ "HSI-I_assembly_Hcp1" ]

[ 7114 ]

1

[]

0

[ "1y12", "3eaa", "3v4h", "4tv4", "4w64", "5xeu", "5xhh", "7fcf", "8yun" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9, 7051, 26, 28 ]

4

[]

0

true

Family

HSI-I assembly protein Hcp1

HSI-I_assembly_Hcp1

9

IPR053166

53,166

UPF0718 putative permease

UPF0718_permease

Family

5,853

true

false

This family of proteins includes putative permeases that may be involved in the transport of molecules across cellular membranes. The specific substrates and mechanisms of transport for the UPF0718 family members are not well characterized. However, as permeases, they likely play a role in the uptake or efflux of essen...

[]

0

[ "PANTHER" ]

[ "PTHR42775" ]

[ "UPF0718_permease" ]

[ 5853 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Plasmid pMCBF1", "unclassified sequences" ]

[ 488, 5225, 5, 1, 134 ]

5

[]

0

true

Family

UPF0718 putative permease

UPF0718_permease

1

IPR053167

53,167

Late-developmental Spore Coat Component

Spore_coat_component

Family

7,100

true

false

This family of proteins includes late-developmental spore coat components. Members are involved in the formation of the protective layer that surrounds spores, which are a dormant form of the organism that can survive in harsh conditions. The protein contributes to the resilience and viability of the spore during perio...

[]

0

[ "PANTHER" ]

[ "PTHR37089" ]

[ "Spore_coat_component" ]

[ 7100 ]

1

[]

0

[ "5d6h", "6fjy", "6fm5", "6fq0", "6fqa", "7zl4", "8cio" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7061, 14, 25 ]

3

[]

0

true

Family

Late-developmental Spore Coat Component

Spore_coat_component

2

IPR053168

53,168

Glutamic endopeptidase

Glutamic_endopeptidase

Family

12,964

true

false

This family of proteins includes glutamic endopeptidases known for their ability to cleave peptide bonds preferentially on the C-terminal side of proline residues, although they can also target bonds on the C-terminal side of alanine residues with lower efficiency. Unlike many proline-cleaving enzymes, they can degrade...

[]

0

[ "PANTHER" ]

[ "PTHR31589" ]

[ "Glutamic_endopeptidase" ]

[ 12964 ]

1

[]

0

[ "7zu8", "7zva", "7zvb", "7zvc", "9qr8" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 241, 12723 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 258, 105, 74 ]

3

true

Family

Glutamic endopeptidase

Glutamic_endopeptidase

9

IPR053169

53,169

Meiotically Up-regulated Gene Protein

MUG_Protein

Family

8,348

true

false

This family of proteins is involved in the regulation of meiotic processes. Members of this family are implicated in the cellular events that occur during meiosis, which is a specialized type of cell division necessary for sexual reproduction in eukaryotes. These proteins may play a role in various stages of meiosis, i...

[]

0

[ "PANTHER" ]

[ "PTHR47791" ]

[ "MUG_Protein" ]

[ 8348 ]

1

[]

0

[ "3k7x", "4boj", "4bok", "4c1s", "4d4a", "4d4b", "4d4c", "4d4d", "4mu9", "4v1r", "4v1s", "5agd", "5m77", "5n0f", "6shd", "6shm", "6u4z", "6y8f", "6zbm", "6zbw", "6zbx", "7nl5", "9r4k", "9r4l", "9r4m", "9r4n", "9r4o", "9r4p", "9r4q", "9r4r", "9r4s", "9r4t"...

33

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 3, 4627, 3700, 18 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1 ]

2

true

Family

Meiotically Up-regulated Gene Protein

MUG_Protein

1

IPR053170

53,170

Negative transcriptional regulator

Transcription_regulator

Family

5,630

true

false

This family of proteins is implicated in the regulation of gene transcription. Members of this family are believed to function as negative regulators, potentially influencing the expression of various genes including those involved in DNA repair, fatty acid biosynthesis, and stress response. The precise regulatory mech...

[]

0

[ "PANTHER" ]

[ "PTHR40031" ]

[ "Transcription_regulator" ]

[ 5630 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 120, 5445, 5, 60 ]

4

[]

0

true

Family

Negative transcriptional regulator

Transcription_regulator

7

IPR053171

53,171

Viral Tip Attachment Protein

Viral_Tip_Attach_Protein

Family

7,275

true

false

This family of proteins is involved in the attachment of virions to host receptors, specifically initiating the process of viral DNA ejection. They play a crucial role in the assembly of the distal tail tip of the virus by interacting with other viral proteins. Additionally, these proteins are responsible for the irrev...

[]

0

[ "PANTHER" ]

[ "PTHR36251" ]

[ "Viral_Tip_Attach_Protein" ]

[ 7275 ]

1

[]

0

[ "8iyk", "8iyl", "8jvm", "8k35", "8xcg", "8xci", "8xcj", "8xck", "9e7m", "9l9p" ]

10

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6546, 58, 625, 46 ]

4

[]

0

true

Family

Viral Tip Attachment Protein

Viral_Tip_Attach_Protein

3

IPR053172

53,172

Tn903 transposase-like

Tn903_transposase

Family

6,351

true

false

This family of proteins includes transposases that are essential for the movement of transposon Tn903 within a genome. Transposases are enzymes that catalyze the cutting and rejoining of DNA strands, thereby enabling the transposition process. The transposition mechanism typically involves the recognition of specific D...

[]

0

[ "PANTHER" ]

[ "PTHR34631" ]

[ "Tn903_transposase" ]

[ 6351 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 308, 5925, 4, 17, 97 ]

5

[]

0

true

Family

Tn903 transposase-like

Tn903_transposase

2

IPR053174

53,174

UDP-2,3-diacylglucosamine pyrophosphatase LpxI

LpxI

Family

3,538

true

This family of proteins includes UDP-2,3-diacylglucosamine pyrophosphatase LpxI which is involved in the biosynthesis of lipid A, a critical component of the lipopolysaccharide that forms the outer membrane of certain bacterial cells. Members of this family act as enzymes that specifically hydrolyse the pyrophosphate b...

[]

0

[ "PANTHER" ]

[ "PTHR39962" ]

[ "LpxI" ]

[ 3538 ]

1

[]

0

[ "4ggm", "4j6e" ]

2

[ "PUB00086024" ]

[ "20608695" ]

[ "An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3464, 4, 70 ]

3

[]

0

true

Family

UDP-2,3-diacylglucosamine pyrophosphatase LpxI

LpxI

5

IPR053176

53,176

Type VI secretion system TssE1-like

T6SS_TssE1-like

Family

5,847

true

false

This family of proteins includes core components of the type VI secretion system (T6SS), specifically the H1-T6SS variant. Members are involved in the secretion of toxins that can target a range of organisms. They play a crucial role in the assembly and stability of the TssB1-sheath structure, which is essential for th...

[]

0

[ "PANTHER" ]

[ "PTHR38595" ]

[ "T6SS_TssE1-like" ]

[ 5847 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Strongyloides venezuelensis", "unclassified sequences" ]

[ 5809, 1, 37 ]

3

[]

0

true

Family

Type VI secretion system TssE1-like

T6SS_TssE1-like

7

IPR053177

53,177

ADP-glucose phosphorylase

ADP-glucose_phosphorylase

Family

2,932

true

false

This family of proteins includes enzymes that are involved in carbohydrate metabolism, specifically in the synthesis of sugar nucleotides. Members of this family are responsible for catalyzing the formation of glucose-1-phosphate from ADP-glucose, releasing ADP in the process. This reaction is a key step in the biosynt...

[]

0

[ "PANTHER" ]

[ "PTHR42763" ]

[ "ADP-glucose_phosphorylase" ]

[ 2932 ]

1

[]

0

[ "1z84", "1zwj", "2h39", "2q4h", "2q4l" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 169, 2003, 628, 132 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 5 ]

3

true

Family

ADP-glucose phosphorylase

ADP-glucose_phosphorylase

8

IPR053179

53,179

LINE-1 ORF2p reverse transcriptase/endonuclease

LINE-1_ORF2_RT/EN

Family

181

true

false

This family of proteins includes enzymes with reverse transcriptase and endonuclease activities, essential for the retrotransposition of LINE-1 elements. The reverse transcriptase function is critical for synthesizing DNA from the LINE-1 mRNA, a key step in the integration of these elements into the genome. Additionall...

[]

0

[ "PANTHER" ]

[ "PTHR25952" ]

[ "LINE-1_ORF2_RT/EN" ]

[ 181 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadota", "marine sediment metagenome" ]

[ 175, 2, 4 ]

3

[ "Homo sapiens" ]

[ 3 ]

1

true

Family

LINE-1 ORF2p reverse transcriptase/endonuclease

LINE-1_ORF2_RT/EN

9

IPR053180

53,180

Calcium-binding acidic-repeat protein

Ca-binding_acidic-rpt_prot

Family

2,289

true

This family of proteins is implicated in calcium ion binding. Members are believed to have a role in cellular processes that are regulated by calcium levels. The exact biological functions may vary among family members, but the common characteristic is the ability to interact with calcium ions, which suggests a potenti...

[]

0

[ "PANTHER" ]

[ "PTHR37467" ]

[ "Ca-binding_acidic-repeat" ]

[ 2289 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 517, 1616, 55, 101 ]

4

[]

0

true

Family

Calcium-binding acidic-repeat protein

Ca-binding_acidic-rpt_prot

9

IPR053182

53,182

Putative transcriptional regulator YobU-like

YobU-like_regulator

Family

5,390

true

false

This family of proteins includes putative transcriptional regulators. The characterized member, YobU from Bacillus subtilis, is annotated as a putative transcriptional regulator, suggesting that proteins in this family may be involved in the regulation of gene expression. Transcriptional regulators are typically involv...

[]

0

[ "PANTHER" ]

[ "PTHR36444" ]

[ "YobU-like_regulator" ]

[ 5390 ]

1

[]

0

[ "3gk6", "3lur", "5kat", "5kau", "5kav", "5kaw", "5kcb", "5xbi" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 5287, 50, 17, 36 ]

4

[]

0

true

Family

Putative transcriptional regulator YobU-like

YobU-like_regulator

1

IPR053183

53,183

Alkali-sensitive linkage protein

ASL1

Family

6,852

true

false

This family of proteins is involved in cellular processes that are sensitive to changes in alkaline conditions. The proteins may play a role in the response to environmental pH shifts, potentially participating in the regulation of pH homeostasis or in signaling pathways that are activated under alkaline stress. The sp...

[]

0

[ "PANTHER" ]

[ "PTHR34154" ]

[ "ASL1" ]

[ 6852 ]

1

[]

0

[ "6uaq", "6uar", "6uas", "6uat", "6uau", "6uav", "6uaw", "6uax", "6uay", "6uaz", "6ub0", "6ub1", "6ub2", "6ub3", "6ub4", "6ub5", "6ub6", "6ub7", "6ub8", "6uba", "6ubb", "6ubc", "6ubd", "6ufl", "6ufz", "8j3x", "8j3y" ]

27

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halococcoides cellulosivorans", "Tetraselmis virus 1", "metagenomes" ]

[ 1315, 5526, 1, 1, 9 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1 ]

2

true

Family

Alkali-sensitive linkage protein

ASL1

6

IPR053185

53,185

SET domain-containing protein

SET_domain_protein

Family

7,371

true

false

This family of proteins includes enzymes that share a SET domain, which is typically involved in the methylation of lysine residues on histone proteins. This post-translational modification is crucial for the regulation of gene expression and can affect chromatin structure and function. Members of this family are likel...

[]

0

[ "PANTHER" ]

[ "PTHR47332" ]

[ "SET_domain_protein" ]

[ 7371 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina", "Satyrvirus sp.", "metagenomes" ]

[ 151, 7208, 6, 1, 5 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 1 ]

2

true

Family

SET domain-containing protein

SET_domain_protein

8

IPR053186

53,186

Quercetin 2,3-dioxygenase-related

QDO-related

Family

4,761

true

false

This family of proteins includes members that are thought to function as quercetin 2,3-dioxygenases. These enzymes are involved in the degradation of flavonoids, a class of plant secondary metabolites with various biological activities. Quercetin 2,3-dioxygenase catalyzes the cleavage of quercetin, a specific flavonoid...

[]

0

[ "PANTHER" ]

[ "PTHR43594" ]

[ "QDO-related" ]

[ 4761 ]

1

[]

0

[ "6d0p", "7te5", "7tfq", "7tg5" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4668, 75, 18 ]

3

[]

0

true

Family

Quercetin 2,3-dioxygenase-related

QDO-related

6

IPR053187

53,187

Notoamide biosynthesis regulator

Notoamide_regulator

Family

6,043

true

false

This family of proteins includes transcription factors that are likely involved in the regulation of gene clusters responsible for the biosynthesis of notoamides. Notoamides are fungal indole alkaloids known for their unique bicyclo[2.2.2]diazaoctane core structure. Members of this family play a key role in the product...

[]

0

[ "PANTHER" ]

[ "PTHR47256" ]

[ "Notoamide_regulator" ]

[ 6043 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6043 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Notoamide biosynthesis regulator

Notoamide_regulator

1

IPR053188

53,188

FkbM Methyltransferase

FkbM_Methyltransferase

Family

3,327

true

false

This family of proteins is involved in the modification of Nod factors, which are signaling molecules central to the establishment of symbiotic relationships between certain plants and nitrogen-fixing bacteria. Specifically, these proteins carry out the 2-O-methylation of the fucosyl group on Nod factors, a modificatio...

[]

0

[ "PANTHER" ]

[ "PTHR36973" ]

[ "FkbM_Methyltransferase" ]

[ 3327 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 9, 3014, 83, 39, 182 ]

5

[]

0

true

Family

FkbM Methyltransferase

FkbM_Methyltransferase

2

IPR053189

53,189

Chloroplast Clp protease adapter protein ClpF

Clp_protease_adapter_ClpF

Family

3,746

true

false

ClpF is involved in the regulation of the plastid Clp protease system, which is essential for the maintenance of chloroplast function and protein quality control. ClpF acts as an adapter protein that facilitates the recruitment of the ClpS1 co-chaperone to ClpC chaperones [ ]. This interaction is crucial for the format...

[]

0

[ "PANTHER" ]

[ "PTHR48439" ]

[ "" ]

[ 3746 ]

1

[]

0

[]

0

[ "PUB00155246" ]

[ "26419670" ]

[ "Discovery of a Unique Clp Component, ClpF, in Chloroplasts: A Proposed Binary ClpF-ClpS1 Adaptor Complex Functions in Substrate Recognition and Delivery." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2158, 1549, 39 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 1, 1, 6, 9 ]

5

true

Family

Chloroplast Clp protease adapter protein ClpF

Clp_protease_adapter_ClpF

4

IPR053190

53,190

Nicotinate phosphoribosyltransferase-like

NAPRTase-like

Family

2,418

true

false

This family of proteins is involved in the biosynthesis of NAD, a crucial coenzyme in redox reactions. Members of this family catalyze the conversion of nicotinate and 5-phospho-D-ribose 1-phosphate into beta-nicotinate D-ribonucleotide, utilizing ATP in the process. The proteins are characterized by a multi-domain str...

[]

0

[ "PANTHER" ]

[ "PTHR43202" ]

[ "NAPRTase-like" ]

[ 2418 ]

1

[]

0

[ "1ytd", "1yte", "1ytk", "2i14", "2i1o" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Protostomia", "metagenomes" ]

[ 670, 1643, 3, 102 ]

4

[]

0

true

Family

Nicotinate phosphoribosyltransferase-like

NAPRTase-like

1

IPR053191

53,191

D-cycloserine Biosynthesis Enzyme

DcsG_Biosynth_Enzyme

Family

3,850

true

false

This family of proteins is involved in the production of the antibiotic D-cycloserine, which is a structural analog of D-alanine and is used to treat tuberculosis. Members of this family are responsible for catalyzing the conversion of O-ureido-D-serine to D-cycloserine. They also interact with other substrates such as...

[]

0

[ "PANTHER" ]

[ "PTHR39217" ]

[ "DcsG_Biosynth_Enzyme" ]

[ 3850 ]

1

[]

0

[ "6jil" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Mimiviridae", "metagenomes" ]

[ 43, 3531, 200, 2, 74 ]

5

[]

0

true

Family

D-cycloserine Biosynthesis Enzyme

DcsG_Biosynth_Enzyme

1

IPR053192

53,192

Vacuole Formation Regulator

Vacuole_Formation_Reg

Family

6,035

true

false

This family of proteins is crucial for plant reproductive development. Members are involved in the formation of large vacuoles, which are essential during the early stages of gametophyte development. They may play a role in the regulation of vesicular fusion, facilitating vacuole formation in both female and male gamet...

[]

0

[ "PANTHER" ]

[ "PTHR32410" ]

[ "Vacuole_Formation_Reg" ]

[ 6035 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6035 ]

1

[ "Arabidopsis thaliana" ]

[ 578 ]

1

true

Family

Vacuole Formation Regulator

Vacuole_Formation_Reg

5

IPR053194

53,194

S-adenosyl-L-methionine-binding protein AF_0433

AF_0433

Family

1,727

true

This entry represents Probable S-adenosyl-L-methionine-binding protein AF_0433. Proteins in this family are likely to bind S-adenosyl-L-methionine (SAM) and transfer a methyl group from SAM to specific nucleotides within tRNA, a process critical for the proper folding, stability, and function of tRNA. Methylation can a...

[]

0

[ "PANTHER" ]

[ "PTHR39418" ]

[ "tRNA_methyltr_O" ]

[ 1727 ]

1

[]

0

[ "2glz", "2gvi", "3d00" ]

3

[]

0

[]

0

null

[ "Aduncisulcus paluster", "Archaea", "Bacteria", "unclassified sequences" ]

[ 1, 540, 1117, 69 ]

4

[]

0

true

Family

S-adenosyl-L-methionine-binding protein AF_0433

AF_0433

6

IPR053195

53,195

Bax-like

Family

2,925

true

false

This family of proteins is involved in a variety of cellular processes. The specific functions may include roles in metabolism, cell signaling, structural integrity, or other essential biological activities. The proteins may act as enzymes, receptors, transporters, or have other functions depending on their structure a...

[]

0

[ "PANTHER" ]

[ "PTHR40572" ]

[ "Bax-like" ]

[ 2925 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured marine group II/III euryarchaeote AD1000_99_D12", "uncultured virus" ]

[ 2854, 4, 65, 1, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bax-like

9

IPR053196

53,196

Uncharacterized lipoprotein YbaY-like

Lipoprotein_YbaY-like

Family

3,343

true

false

This family of proteins includes uncharacterized lipoproteins, such as YbaY from E. coli. Lipoproteins are typically associated with the bacterial cell membrane and can play diverse roles, including structural functions, acting as enzymes, or serving as factors in signal transduction. Given the uncharacterized nature o...

[]

0

[ "PANTHER" ]

[ "PTHR38013" ]

[ "Lipoprotein_YbaY-like" ]

[ 3343 ]

1

[]

0

[ "5wec" ]

1

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 3288, 50, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterized lipoprotein YbaY-like

Lipoprotein_YbaY-like

8

IPR053197

53,197

F-box/SCF ubiquitin ligase complex component

F-box_SCFL_complex_component

Family

8,305

true

false

This family of proteins includes members that are likely part of the SCF (SKP1-CULLIN-F-box) E3 ubiquitin-protein ligase complex, suggesting a role in the ubiquitin-mediated protein degradation or signaling pathways. They are implicated in male meiotic prophase I progression, including telomere bouquet formation, homol...

[]

0

[ "PANTHER" ]

[ "PTHR34223" ]

[ "F-box_SCFL_complex_component" ]

[ 8305 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 8305 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 308, 15 ]

3

true

Family

F-box/SCF ubiquitin ligase complex component

F-box_SCFL_complex_component

7

IPR053198

53,198

Gynoecium Development Regulator

Gynoecium_Dev_Regulator

Family

6,458

true

false

This family of proteins is involved in the regulation of cell growth anisotropy during the development of the gynoecium, which is the female reproductive part of a flower. Members of this family work in conjunction with other proteins to coordinate cell-cell communication with cellular growth processes. Through this co...

[]

0

[ "PANTHER" ]

[ "PTHR31066" ]

[ "Gynoecium_Dev_Regulator" ]

[ 6458 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viridiplantae" ]

[ 6458 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 53, 33, 50 ]

3

true

Family

Gynoecium Development Regulator

Gynoecium_Dev_Regulator

6

IPR053199

53,199

Cyclic 2,3-diphosphoglycerate synthetase-like

cDPG_synthetase-like

Family

810

true

This family of proteins includes enzymes that are responsible for the synthesis of cyclic 2,3-diphosphoglycerate (cDPG), a molecule with a role in adaptation to extreme environments. Members of this family catalyze the formation of cDPG through an ATP-dependent mechanism, creating an intramolecular phosphoanhydride bon...

[]

0

[ "PANTHER" ]

[ "PTHR42869" ]

[ "cDPG_synthetase" ]

[ 810 ]

1

[]

0

[]

0

[ "PUB00154535" ]

[ "38602916" ]

[ "An energy-conserving reaction in amino acid metabolism catalyzed by arginine synthetase." ]

[ 2024 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 188, 480, 50, 92 ]

4

[]

0

true

Family

Cyclic 2,3-diphosphoglycerate synthetase-like

cDPG_synthetase-like

9

IPR053200

53,200

Multidrug efflux protein YfmO-like

YfmO-like

Family

3,320

false

This protein family includes Multidrug efflux protein YfmO from Bacillus subtilis and similar proteins mainly found in bacilli and actinomycetes. YfmO functions to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance [ ]. Members of this entry are part of the major facilitat...

[]

0

[ "PANTHER" ]

[ "PTHR43683" ]

[ "" ]

[ 3320 ]

1

[]

0

[]

0

[ "PUB00080749" ]

[ "14663075" ]

[ "Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon." ]

[ 2003 ]

1

[ "IPR001958" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 42, 3270, 3, 5 ]

4

[]

0

true

Family

Multidrug efflux protein YfmO-like

YfmO-like

1

IPR053201

53,201

Flavunoidine biosynthesis N-methyltransferase

Flavunoidine_N-MTase

Family

2,677

true

false

This family of proteins includes N-methyltransferases involved in the biosynthesis of complex alkaloidal terpenoids. They catalyze the methylation of L-lysine to produce N,N-dimethyl-L-lysine, a precursor for the synthesis of dimethylcadaverine. This reaction is a key step in the formation of flavunoidine, a compound w...

[]

0

[ "PANTHER" ]

[ "PTHR12350" ]

[ "Flavunoidine_N-MTase" ]

[ 2677 ]

1

[]

0

[ "9l4t", "9l4v" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 8, 803, 1819, 46, 1 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Flavunoidine biosynthesis N-methyltransferase

Flavunoidine_N-MTase

3

IPR053202

53,202

EGF Receptor Signaling Regulator

EGF_Rcpt_Signaling_Reg

Family

3,624

true

false

This family of proteins is involved in early developmental processes, specifically in the formation and differentiation of photoreceptors. Members of this family play a crucial role in the epidermal growth factor (EGF) receptor signaling pathway. They are known to interact with specific receptors, such as the torpedo r...

[]

0

[ "PANTHER" ]

[ "PTHR34009" ]

[ "EGF_Rcpt_Signaling_Reg" ]

[ 3624 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6, 1131, 2380, 15, 92 ]

5

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Family

EGF Receptor Signaling Regulator

EGF_Rcpt_Signaling_Reg

3

IPR053203

53,203

Cisplatin resistance-associated protein

Cisplatin_resist-associated

Family

4,074

true

false

This family of proteins is associated with cellular mechanisms that confer resistance to the chemotherapeutic agent cisplatin. Members of this family are implicated in processes that likely involve the recognition and repair of cisplatin-induced DNA damage or the modulation of cellular pathways to mitigate the toxic ef...

[]

0

[ "PANTHER" ]

[ "PTHR34693" ]

[ "Cisplatin_resist-associated" ]

[ 4074 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 4073, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 4, 1 ]

2

true

Family

Cisplatin resistance-associated protein

Cisplatin_resist-associated

9

IPR053204

53,204

Oxopyrrolidines Biosynthesis-associated Protein

Oxopyrrolidines_Biosynth-assoc

Family

3,819

true

false

This family of proteins is involved in the biosynthesis of oxopyrrolidines, which are polyketide-amino acid hybrid compounds characterized by tetramic acid structures. Although members of this family are associated with a gene cluster responsible for oxopyrrolidines production, they do not appear to contribute to the b...

[]

0

[ "PANTHER" ]

[ "PTHR38797" ]

[ "Oxopyrrolidines_Biosynth-assoc" ]

[ 3819 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Eukaryota" ]

[ 17, 3802 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Oxopyrrolidines Biosynthesis-associated Protein

Oxopyrrolidines_Biosynth-assoc

9

IPR053205

53,205

GHMP kinase superfamily L-arabinokinase

GHMP_kinase_L-arabinokinase

Family

2,499

true

false

This family of proteins includes enzymes that are involved in the metabolic conversion of L-arabinose, a type of sugar, into its activated form, UDP-L-arabinose. This process is part of the salvage pathway, which recycles free sugars for further biochemical utilization. Members of this family are also suggested to have...

[]

0

[ "PANTHER" ]

[ "PTHR38134" ]

[ "GHMP_kinase_L-arabinokinase" ]

[ 2499 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 13, 836, 1629, 21 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 6, 24 ]

3

true

Family

GHMP kinase superfamily L-arabinokinase

GHMP_kinase_L-arabinokinase

4

IPR053207

53,207

Non-NMDA Glutamate Receptor Accessory Protein

Non-NMDA_GluR_Accessory

Family

3,811

true

false

This family of proteins includes accessory components that are essential for modulating glutamate-gated ion currents. Members of this family are believed to influence the gating mechanisms of ionotropic glutamate receptors, specifically those that are not classified as NMDA receptors. These proteins may play a role in ...

[]

0

[ "PANTHER" ]

[ "PTHR47537" ]

[ "Non-NMDA_GluR_Accessory" ]

[ 3811 ]

1

[ "REACTOME" ]

[ "R-CEL-196791" ]

[ "REACTOME:R-CEL-196791" ]

1

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 3811 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 5, 21 ]

2

true

Family

Non-NMDA Glutamate Receptor Accessory Protein

Non-NMDA_GluR_Accessory

7

IPR053208

53,208

GMC Oxidoreductase Cellobiose Dehydrogenase

GMC_Oxidoreductase_CD

Family

3,678

true

false

This family of proteins is involved in the degradation of plant cell wall components, specifically lignin and cellulose. Members of this family have the ability to oxidize cellobiose, a disaccharide derived from the hydrolysis of cellulose, converting it into cellobionolactone. The enzymatic activity of these proteins ...

[]

0

[ "PANTHER" ]

[ "PTHR47190" ]

[ "GMC_Oxidoreductase_CD" ]

[ 3678 ]

1

[]

0

[ "1kdg", "1naa", "4qi3", "4qi4", "4qi5", "4qi6", "4qi7" ]

7

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3678 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

GMC Oxidoreductase Cellobiose Dehydrogenase

GMC_Oxidoreductase_CD

4

IPR053209

53,209

Gramillin-biosynthesis-related methyltransferase

Gramillin-biosynth_MTr

Family

3,598

true

false

This family of proteins includes methyltransferases involved in the biosynthesis of specialized lipopeptides, such as gramillins. These enzymes participate in various steps of the biosynthetic pathway, including initiation of fatty acid synthesis, hydroxylation, oxidation, transamination, and disulfide bond formation. ...

[]

0

[ "PANTHER" ]

[ "PTHR47643" ]

[ "Gramillin-biosynth_MTr" ]

[ 3598 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 3596, 2 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 2 ]

3

true

Family

Gramillin-biosynthesis-related methyltransferase

Gramillin-biosynth_MTr

5

IPR053210

53,210

Ankyrin repeat domain-containing protein 12

ANKRD12

Family

3,550

true

false

This family of proteins includes members that are involved in the regulation of gene expression by modulating the chromatin structure. They are known to interact with histone deacetylases (HDACs) and p160 coactivators, which are part of the nuclear receptor complexes. Through these interactions, they can inhibit the tr...

[]

0

[ "PANTHER" ]

[ "PTHR24149" ]

[ "ANKRD12" ]

[ 3550 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halovivax cerinus", "Herpesvirales" ]

[ 28, 3519, 1, 2 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 10, 3, 8, 15, 1, 4 ]

6

true

Family

Ankyrin repeat domain-containing protein 12

ANKRD12

6

IPR053211

53,211

DNA damage-repair/toleration-associated protein

DNA_repair-toleration

Family

7,969

true

false

This family of proteins is involved in DNA damage repair and toleration. Members of this family have been shown to have the ability to complement bacterial recA mutations, indicating a role in DNA repair mechanisms. However, the specific function of these proteins within their native plant organisms remains to be fully...

[]

0

[ "PANTHER" ]

[ "PTHR48060" ]

[ "DNA_repair-toleration" ]

[ 7969 ]

1

[]

0

[ "4mn8", "4z63", "4z64", "5gij", "5gqr", "5gr9", "5jfi", "5jfk", "5xkj", "8wec", "8wed", "9s90", "9s96", "9s9a", "9s9c" ]

15

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Hokovirus HKV1", "ecological metagenomes" ]

[ 139, 7822, 1, 7 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 45, 42, 18 ]

3

true

Family

DNA damage-repair/toleration-associated protein

DNA_repair-toleration

4

IPR053213

53,213

Receptor-like protein 29

RLP29

Family

4,442

true

false

This family of proteins includes receptors that are structurally similar to known receptor-like proteins (RLPs). RLPs typically function in signal transduction pathways and are involved in various biological processes, including development, immunity, and stress responses in plants. They are characterized by an extrace...

[]

0

[ "PANTHER" ]

[ "PTHR48009" ]

[ "RLP29" ]

[ 4442 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 70, 4371, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 25, 17, 17 ]

3

true

Family

Receptor-like protein 29

RLP29

3

IPR053214

53,214

Secreted chitinase LysM12-like

LysM12-like

Family

3,396

true

This family of proteins includes enzymes that exhibit exochitinase activity, which is involved in the degradation of chitin [ ]. Some members of this family are part of a multi-subunit toxin complex where one subunit acts as an exochitinase, contributing to the interaction with sensitive cells. This interaction facilit...

[]

0

[ "PANTHER" ]

[ "PTHR47700" ]

[ "Killer_toxin_exochitinase-rel" ]

[ 3396 ]

1

[]

0

[]

0

[ "PUB00001396", "PUB00154508" ]

[ "2070799", "32656702" ]

[ "Kluyveromyces lactis toxin has an essential chitinase activity.", "Multiple transcriptomic analyses and characterization of pathogen-related core effectors and LysM family members reveal their differential roles in fungal growth and pathogenicity in Penicillium expansum." ]

[ 1991, 2020 ]

2

[]

0

null

[ "Eukaryota", "uncultured organism" ]

[ 3387, 9 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Secreted chitinase LysM12-like

LysM12-like

5

IPR053215

53,215

TKL Ser/Thr protein kinase

TKL_Ser/Thr_kinase

Family

3,695

true

false

This family of proteins includes serine/threonine-protein kinases that are part of the protein kinase superfamily. Members of this family are characterized by their ability to phosphorylate various substrates on serine or threonine residues, which is a fundamental mechanism for regulating protein function and signaling...

[]

0

[ "PANTHER" ]

[ "PTHR45756" ]

[ "TKL_Ser/Thr_kinase" ]

[ 3695 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eptesipox virus", "Eukaryota", "Gammaproteobacteria", "marine sediment metagenome" ]

[ 1, 3691, 2, 1 ]

4

[ "Mus musculus" ]

[ 1 ]

1

true

Family

TKL Ser/Thr protein kinase

TKL_Ser/Thr_kinase

7

IPR053216

53,216

Appressorial penetration-associated

Appressorial_penetr-assoc

Family

2,624

true

false

This family of proteins includes secreted factors that are essential for the initial stages of host invasion by certain pathogens. Members are involved in the penetration of host epidermal cells, a critical step for establishing infection. These proteins are not required for the later stages of infection, such as biotr...

[]

0

[ "PANTHER" ]

[ "PTHR34587" ]

[ "Appressorial_penetr-assoc" ]

[ 2624 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 16, 2608 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Appressorial penetration-associated

Appressorial_penetr-assoc

9

IPR053217

53,217

Acetyl-CoA Carboxylase Biotin Carboxyl Carrier

ACC_Biotin_Carrier

Family

1,834

true

false

This family of proteins includes components of the acetyl coenzyme A carboxylase complex. Members of this family are involved in the initial carboxylation of biotin by biotin carboxylase and the subsequent transfer of the carboxyl group to acetyl-CoA to form malonyl-CoA, a critical step in fatty acid biosynthesis.

[]

0

[ "PANTHER" ]

[ "PTHR47597" ]

[ "ACC_Biotin_Carrier" ]

[ 1834 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 348, 1484, 2 ]

3

[ "Arabidopsis thaliana" ]

[ 16 ]

1

true

Family

Acetyl-CoA Carboxylase Biotin Carboxyl Carrier

ACC_Biotin_Carrier

4

IPR053218

53,218

Pathogen-related defense protein

Pathogen-related_defense

Family

3,027

true

false

This family of proteins includes members that are typically associated with plant defense responses. They are often induced by pathogen attack and are part of the plant's innate immune system. These proteins can be involved in various mechanisms, such as the strengthening of cell walls, inhibition of pathogen enzymes, ...

[]

0

[ "PANTHER" ]

[ "PTHR31723" ]

[ "Pathogen-related_defense" ]

[ 3027 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 323, 2704 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 11, 10 ]

3

true

Family

Pathogen-related defense protein

Pathogen-related_defense

4

IPR053219

53,219

G-protein coupled receptor Dmsr-1

GPCR_Dmsr-1

Family

2,927

false

This entry represents the Dmsr-1 (DroMyoSuppressin Receptor related-1) protein, a G-protein coupled receptor that functions as a receptor for FLP-13 neuropeptides in Caenorhabditis elegans. DMSR-1 is activated by neuropeptides with an amidated Arginine-Phenylalanine (RFamide) C terminus motif, particularly FLP-13 pepti...

[]

0

[ "PANTHER" ]

[ "PTHR46273" ]

[ "" ]

[ 2927 ]

1

[]

0

[]

0

[ "PUB00160476" ]

[ "28094002" ]

[ "The RFamide receptor DMSR-1 regulates stress-induced sleep in <i>C. elegans</i>." ]

[ 2017 ]

1

[ "IPR019427" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2927 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 12, 10 ]

2

true

Family

G-protein coupled receptor Dmsr-1

GPCR_Dmsr-1

3

IPR053220

53,220

Nematode receptor-like serpentine class H

Nematode_rcpt-like_serp_H

Family

1,890

true

false

This family of proteins is characterized by its role in the nematode sensory system. Members of this family are typically G protein-coupled receptors (GPCRs) that are involved in the detection of environmental cues and the regulation of behaviors such as chemotaxis, thermotaxis, and mating. These receptors are distingu...

[]

0

[ "PANTHER" ]

[ "PTHR22941" ]

[ "Nematode_rcpt-like_serp_H" ]

[ 1890 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1890 ]

1

[ "Caenorhabditis elegans" ]

[ 177 ]

1

true

Family

Nematode receptor-like serpentine class H

Nematode_rcpt-like_serp_H

9

IPR053221

53,221

Burnettramic acid biosynthesis protein

Burnettramic_acid_biosynth

Family

2,556

true

false

This family of proteins is involved in the biosynthesis of burnettramic acids, which are bolaamphiphilic pyrrolizidinediones with antibacterial, antifungal, and cytotoxic properties. Members of this family participate in various steps of the biosynthetic pathway, including the hydroxylation of proline, construction of ...

[]

0

[ "PANTHER" ]

[ "PTHR38887" ]

[ "Burnettramic_acid_biosynth" ]

[ 2556 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fungi" ]

[ 2556 ]

1

[]

0

true

Family

Burnettramic acid biosynthesis protein

Burnettramic_acid_biosynth

7