LiteFold/InterPro · Datasets at Hugging Face

IPR052881

52,881

Keratinocyte Proline-Rich

Keratinocyte_PR

Family

260

true

false

This family of proteins is involved in the structural organization of keratinocytes, which are the predominant cell type in the epidermis, the outermost layer of the skin. They are characterized by a proline-rich region that suggests a role in protein-protein interactions. These interactions are crucial for the formati...

[]

0

[ "PANTHER" ]

[ "PTHR48138" ]

[ "Keratinocyte_PR" ]

[ 260 ]

1

[ "REACTOME" ]

[ "R-HSA-9725554" ]

[ "REACTOME:R-HSA-9725554" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Heunggongvirae", "viral metagenome" ]

[ 26, 231, 2, 1 ]

4

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1, 3, 1 ]

4

true

Family

Keratinocyte Proline-Rich

Keratinocyte_PR

6

IPR052882

52,882

EZH Inhibitory Protein

EZH_Inhibitor

Family

227

true

false

This family of proteins includes inhibitors of the PRC2 complex, which consists of EED, EZH1, and EZH2 components. Members of this family negatively regulate the methyltransferase activity of EZH1 and EZH2, leading to decreased levels of histone H3 trimethylation at lysine 27 (H3K27me3). This action is thought to occur...

[]

0

[ "PANTHER" ]

[ "PTHR22467" ]

[ "EZH_Inhibitor" ]

[ 227 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 227 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 28, 3, 12, 1 ]

4

true

Family

EZH Inhibitory Protein

EZH_Inhibitor

9

IPR052883

52,883

Hisactophilin

Family

286

true

false

This family of proteins may function as intracellular pH sensors that are potentially involved in linking chemotactic signals to the cytoskeletal system. They are implicated in the regulation of actin dynamics, either by initiating the polymerization of actin or by maintaining the stability of actin filaments. These ac...

[]

0

[ "PANTHER" ]

[ "PTHR33351" ]

[ "Hisactophilin" ]

[ 286 ]

1

[]

0

[ "1hcd", "1hce" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Pandoravirus", "uncultured marine group II/III euryarchaeote KM3_172_F11" ]

[ 26, 237, 22, 1 ]

4

[ "Caenorhabditis elegans" ]

[ 3 ]

1

true

Family

Hisactophilin

2

IPR052884

52,884

Vacuolar Import and Degradation Regulator

VID_Regulator

Family

207

true

false

This family of proteins is involved in the regulation of metabolic processes, specifically in the negative regulation of gluconeogenesis. Members of this family are implicated in the transport of certain enzymes into vesicles for degradation, playing a role in the maintenance of cellular metabolic balance. The characte...

[]

0

[ "PANTHER" ]

[ "PTHR35261" ]

[ "VID_Regulator" ]

[ 207 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 207 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Vacuolar Import and Degradation Regulator

VID_Regulator

3

IPR052885

52,885

Dictyostelium Calcium-Dependent Adhesion Molecules

Dictyostelium_CAD

Family

177

true

false

The Dictyostelium CAD family is characterized by its role in mediating calcium-dependent cell-cell adhesion, which is crucial during the early stages of development. Members of the family are involved in the formation of cell assemblies by adhering to one another in a calcium-dependent manner. The adhesive function is ...

[]

0

[ "PANTHER" ]

[ "PTHR38083" ]

[ "Dictyostelium_CAD" ]

[ 177 ]

1

[]

0

[ "1yhp", "2b1o", "5z6d", "5z6e" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 99, 78 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Dictyostelium Calcium-Dependent Adhesion Molecules

Dictyostelium_CAD

3

IPR052886

52,886

Linker Cell Survival and Transcription Coactivator/Chloroplast RNA Splicing Factor

LCS_TC/CRSF

Family

195

true

false

The protein family encompasses diverse functions, including the promotion of linker cell survival and its non-apoptotic death in nematodes, acting as a coactivator in the transcription of RNA polymerase II-dependent genes in slime molds, and involvement in chloroplast RNA splicing in green algae. In nematodes, the fami...

[]

0

[ "PANTHER" ]

[ "PTHR23261" ]

[ "LCS_TC/CRSF" ]

[ 195 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 10, 185 ]

2

[ "Caenorhabditis elegans" ]

[ 2 ]

1

true

Family

Linker Cell Survival and Transcription Coactivator/Chloroplast RNA Splicing Factor

LCS_TC/CRSF

5

IPR052887

52,887

FLYWCH-type zinc finger-containing protein

FLYWCH-type_ZF

Family

150

true

false

This family of proteins includes transcription factors characterized by their ability to bind DNA and repress the expression of target genes, which notably include micro-RNA genes. Members of this family are known to act redundantly with at least one other family member in their biological context. They recognize speci...

[]

0

[ "PANTHER" ]

[ "PTHR37975" ]

[ "FLYWCH-type_ZF" ]

[ 150 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 150 ]

1

[ "Caenorhabditis elegans" ]

[ 3 ]

1

true

Family

FLYWCH-type zinc finger-containing protein

FLYWCH-type_ZF

8

IPR052888

52,888

Proline-rich region-containing protein 9

PRR9

Family

129

false

This family of proteins describes proline-rich protein 9 found in mammalian organisms. Small proline-rich proteins (SPRRs) are a family of proteins primarily involved in maintaining epithelial barrier integrity and antimicrobial defence. They are critical components of the cornified cell envelope, where they function a...

[]

0

[ "PANTHER" ]

[ "PTHR48427" ]

[ "" ]

[ 129 ]

1

[]

0

[]

0

[ "PUB00160395" ]

[ "36057494" ]

[ "Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins." ]

[ 2023 ]

1

[]

0

null

[ "Bilateria" ]

[ 129 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2 ]

3

true

Family

Proline-rich region-containing protein 9

PRR9

2

IPR052889

52,889

C. elegans Fungus-Induced Response

Celegans_Fungus-Induced_Rsp

Family

47

true

false

The protein family, which includes Fungus-induced-related protein 15, Fungus-induced protein 3, and Fungus-induced-related protein 16, is characterized by a potential role in the organism's response to fungal infection. Members of the family may be involved in the hypoxia response, suggesting a function related to cell...

[]

0

[ "PANTHER" ]

[ "PTHR39380" ]

[ "Celegans_Fungus-Induced_Rsp" ]

[ 47 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 47 ]

1

[ "Caenorhabditis elegans" ]

[ 8 ]

1

true

Family

C. elegans Fungus-Induced Response

Celegans_Fungus-Induced_Rsp

7

IPR052891

52,891

DNA-3-methyladenine glycosylase

DNA-3mA_glycosylase

Family

22,135

true

false

This family of proteins is involved in the repair of damaged DNA. Members of this family are enzymes that recognize and excise 3-methyladenine, a non-bulky alkylated base, from the DNA helix. This is achieved through the hydrolysis of the deoxyribose N-glycosidic bond. The excision of this lesion is crucial for maintai...

[]

0

[ "PANTHER" ]

[ "PTHR30037" ]

[ "DNA-3mA_glycosylase" ]

[ 22135 ]

1

[]

0

[ "1lmz", "1nku", "1p7m", "2jg6", "2ofi", "2ofk", "4ai4", "4ai5", "4aia" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 78, 21630, 177, 250 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA-3-methyladenine glycosylase

DNA-3mA_glycosylase

9

IPR052892

52,892

Nucleic_acid-targeting_endonuclease

NA-targeting_endonuclease

Family

18,067

true

false

This family of proteins includes enzymes involved in nucleic acid modification and interaction. One member functions in the CRISPR adaptive immune system, utilizing guide RNAs to identify and cleave foreign DNA sequences in a sequence-specific manner, which is essential for the defense against invading genetic elements...

[]

0

[ "PANTHER" ]

[ "PTHR33877" ]

[ "NA-targeting_endonuclease" ]

[ 18067 ]

1

[]

0

[ "4h9d", "6ghc", "8d2k", "8d2l", "8d2n", "8d2o", "8d2p", "8d2q", "8w2s", "8w2z", "8zq9", "9ar5", "9auf", "9lgi" ]

14

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 152, 16128, 864, 350, 573 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 3, 2 ]

4

true

Family

Nucleic_acid-targeting_endonuclease

NA-targeting_endonuclease

1

IPR052893

52,893

Two-component system response regulator

TCS_response_regulator

Family

20,302

true

false

This family of proteins includes members that are part of two-component regulatory systems, which are typically involved in response to environmental stimuli. These proteins function as response regulators that receive signals from associated sensor kinases and effect changes in gene expression, typically to adapt to v...

[]

0

[ "PANTHER" ]

[ "PTHR44520" ]

[ "TCS_response_regulator" ]

[ 20302 ]

1

[]

0

[ "1i3c", "1jlk", "1k66", "1k68", "2qvg", "3heb", "4zyl", "5brj", "5ic5", "5te9", "6xvu" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 739, 19375, 12, 176 ]

4

[]

0

true

Family

Two-component system response regulator

TCS_response_regulator

7

IPR052894

52,894

AsmA-related

Family

24,645

true

false

This family of proteins is implicated in the process of outer membrane protein assembly. One member is specifically involved in preventing the assembly of defective versions of the OmpF protein, suggesting a quality control role in the biogenesis of membrane components. The broader function of the family appears to be ...

[]

0

[ "PANTHER" ]

[ "PTHR30441" ]

[ "AsmA-related" ]

[ 24645 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24304, 50, 291 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

AsmA-related

5

IPR052895

52,895

Heterokaryon Regulation/Transcriptional Modulator

HetReg/Transcr_Mod

Family

35,144

true

false

This family of proteins is involved in diverse cellular processes including non-self-recognition and growth regulation in fungi. Members of this family play a role in restricting heterokaryon formation by recognizing genetic differences at specific loci, which is crucial for maintaining organismal integrity during asex...

[]

0

[ "PANTHER" ]

[ "PTHR24148" ]

[ "HetReg/Transcr_Mod" ]

[ 35144 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadota", "sediment metagenome" ]

[ 35141, 2, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 16 ]

1

true

Family

Heterokaryon Regulation/Transcriptional Modulator

HetReg/Transcr_Mod

5

IPR052896

52,896

Gamma-glutamyltransferase-like enzyme

GGT-like_enzyme

Family

17,670

true

false

This family of proteins includes enzymes that are structurally related and share a common evolutionary origin, as suggested by their membership in the gamma-glutamyltransferase family. Members of this family are involved in various biochemical processes. One characterized member is implicated in the uric acid degradati...

[]

0

[ "PANTHER" ]

[ "PTHR43881" ]

[ "GGT-like_enzyme" ]

[ 17670 ]

1

[]

0

[ "2i3o", "2nlz", "5hft", "6j3a", "6j3i" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 378, 14104, 2793, 395 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Gamma-glutamyltransferase-like enzyme

GGT-like_enzyme

1

IPR052897

52,897

Secondary metabolite biosynthesis hydrolase

Sec-Metab_Biosynth_Hydrolase

Family

25,510

false

This family of proteins includes alpha/beta hydrolases from bacteria and fungi, involved in complex biosynthetic pathways for the production of secondary metabolites with diverse biological activities. Members of this family function as epimerases, esterases, and dehydrogenases, participating in the synthesis of compou...

[]

0

[ "PANTHER" ]

[ "PTHR37017" ]

[ "" ]

[ 25510 ]

1

[]

0

[ "6tj2", "7wwf" ]

2

[ "PUB00094684", "PUB00097861", "PUB00155016" ]

[ "27056201", "29968715", "20228105" ]

[ "Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues.", "Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation.", "Cloning and biochemical characterization of a novel carbendazim (methyl-1H-...

[ 2016, 2018, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Klosneuvirinae", "unclassified sequences" ]

[ 27, 18186, 7235, 2, 60 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Secondary metabolite biosynthesis hydrolase

Sec-Metab_Biosynth_Hydrolase

2

IPR052898

52,898

Acyl-CoA dehydrogenase 10-like

ACAD10-like

Family

18,452

true

false

This family of proteins includes acyl-CoA dehydrogenases that are specifically active with R- and S-2-methyl-C15-CoA substrates. These enzymes play a crucial role in the metabolism of fatty acids, participating in the beta-oxidation pathway by introducing a double bond between the alpha and beta carbon atoms of acyl-Co...

[]

0

[ "PANTHER" ]

[ "PTHR47829" ]

[ "ACAD10-like" ]

[ 18452 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-77289", "R-MMU-77289" ]

[ "REACTOME:R-HSA-77289", "REACTOME:R-MMU-77289" ]

2

[ "3dxp", "5mwa" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 212, 12439, 5420, 381 ]

4

[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 9, 2, 2, 1, 8, 4 ]

7

true

Family

Acyl-CoA dehydrogenase 10-like

ACAD10-like

1

IPR052899

52,899

Class-I DAHP synthase

Class-I_DAHP_synthase

Family

11,987

true

false

This family of proteins includes enzymes that catalyze the first step in the shikimate pathway, which is the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) to produce 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). This reaction is a key regulatory point in the biosynthesis of aromatic ...

[]

0

[ "PANTHER" ]

[ "PTHR43018" ]

[ "Class-I_DAHP_synthase" ]

[ 11987 ]

1

[]

0

[ "1rzm", "1vr6", "1vs1", "1zco", "3nvt", "3pg8", "3pg9", "3tfc", "4c1k", "4c1l", "4grs", "5j6f" ]

12

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 147, 11535, 19, 4, 282 ]

5

[]

0

true

Family

Class-I DAHP synthase

Class-I_DAHP_synthase

2

IPR052900

52,900

Phospholipid Metabolizing Enzymes

Phospholipid_Metab_Enz

Family

17,084

true

false

This family of proteins includes enzymes with diverse catalytic activities, primarily involved in the metabolism of phospholipids. Members of this family are capable of catalyzing the hydrolysis of phospholipids, releasing phosphatidic acid and an alcohol. Additionally, they can perform a transphosphatidylation reactio...

[]

0

[ "PANTHER" ]

[ "PTHR43606" ]

[ "Phospholipid_Metab_Enz" ]

[ 17084 ]

1

[]

0

[ "2yeq" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "unclassified sequences" ]

[ 13632, 3204, 139, 9, 100 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 4 ]

1

true

Family

Phospholipid Metabolizing Enzymes

Phospholipid_Metab_Enz

6

IPR052902

52,902

ABC-2 integral membrane transporter

ABC-2_transporter

Family

10,674

true

false

This family of proteins is involved in the transport of specific substrates across cellular membranes. Members are likely part of an ABC transporter complex that confers resistance to certain compounds, such as the antibiotic doxorubicin. These proteins are thought to play a key role in the translocation process of the...

[]

0

[ "PANTHER" ]

[ "PTHR43027" ]

[ "ABC-2_transporter" ]

[ 10674 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 108, 10419, 3, 144 ]

4

[]

0

true

Family

ABC-2 integral membrane transporter

ABC-2_transporter

3

IPR052904

52,904

Acyl-CoA dehydrogenase-like protein

Acyl-CoA_dehydrogenase-like

Family

14,386

true

false

This family of proteins includes enzymes that are involved in the metabolism of fatty acids and potentially in DNA repair mechanisms. Members of this family are characterized by their ability to bind to and modify fatty acids or to interact with DNA. They may participate in adaptive responses to environmental stresses,...

[]

0

[ "PANTHER" ]

[ "PTHR42707" ]

[ "Acyl-CoA_dehydrogenase-like" ]

[ 14386 ]

1

[]

0

[ "3djl", "3u33", "4y9j", "4y9l", "5ez3", "6sd8", "6sda" ]

7

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 158, 11388, 2758, 82 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 3, 1, 1 ]

4

true

Family

Acyl-CoA dehydrogenase-like protein

Acyl-CoA_dehydrogenase-like

3

IPR052905

52,905

L,D-transpeptidase YkuD-like

LD-transpeptidase_YkuD-like

Family

12,063

true

false

This family of proteins includes L,D-transpeptidases that are likely involved in the synthesis of bacterial cell walls by catalyzing the formation of a specific type of cross-link between peptidoglycan strands. These enzymes are characterized by their ability to generate meso-diaminopimelyl-3 to meso-diaminopimelyl-3 c...

[]

0

[ "PANTHER" ]

[ "PTHR41533" ]

[ "LD-transpeptidase_YkuD-like" ]

[ 12063 ]

1

[]

0

[ "6ntw", "7aj9", "7ajo", "7ajx", "7ajz", "7kgm", "7kgn" ]

7

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2, 11961, 11, 3, 86 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

L,D-transpeptidase YkuD-like

LD-transpeptidase_YkuD-like

4

IPR052906

52,906

Type IV Methyl-Directed Restriction Enzyme

Type_IV_Methyl-Rstrct_Enzyme

Family

12,894

true

false

This family of proteins includes Type IV methyl-directed restriction enzymes such as EcoKMrr from E. coli. These enzymes play a crucial role in bacterial defense mechanisms by recognizing and restricting foreign DNA that is methylated. They are capable of targeting DNA that contains methylated adenine or cytosine bases...

[]

0

[ "PANTHER" ]

[ "PTHR30015" ]

[ "Type_IV_Methyl-Rstrct_Enzyme" ]

[ 12894 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "IncN plasmid pKM101", "metagenomes", "unclassified Caudoviricetes" ]

[ 659, 12094, 23, 1, 103, 14 ]

6

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type IV Methyl-Directed Restriction Enzyme

Type_IV_Methyl-Rstrct_Enzyme

8

IPR052907

52,907

Beta-lactamase/esterase domain-containing protein

Beta-lactamase/esterase

Family

12,796

true

false

This family of proteins exhibits enzymatic activities associated with the hydrolysis of ester and beta-lactam bonds. Members of this family are characterized by their ability to act as esterases, preferentially cleaving short-chain p-nitrophenol esters, as well as beta-lactamases, targeting substrates with a beta-lacta...

[]

0

[ "PANTHER" ]

[ "PTHR43319" ]

[ "Beta-lactamase/esterase" ]

[ 12796 ]

1

[]

0

[ "3zyt", "5gkv", "5gmx", "7y3z", "8j5v" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Tupanvirus", "unclassified sequences" ]

[ 9215, 3263, 144, 2, 172 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Zea mays" ]

[ 1, 7, 6 ]

3

true

Family

Beta-lactamase/esterase domain-containing protein

Beta-lactamase/esterase

3

IPR052908

52,908

AP-4-A phosphorylase

AP-4-A_phosphorylase

Family

8,526

true

false

This family of proteins is involved in the catabolism of diadenosine polyphosphates. Specifically, they catalyze the breakdown of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into adenosine diphosphate (ADP) and adenosine triphosphate (ATP). These enzymes prefer substrates that are dinucleoside polyphosphates with f...

[]

0

[ "PANTHER" ]

[ "PTHR42997" ]

[ "AP-4-A_phosphorylase" ]

[ 8526 ]

1

[]

0

[ "3ano", "3wo5", "6af2" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Cyanidioschyzon merolae (strain NIES-3377 / 10D)", "unclassified sequences" ]

[ 700, 7425, 3, 1, 397 ]

5

[]

0

true

Family

AP-4-A phosphorylase

AP-4-A_phosphorylase

9

IPR052909

52,909

Transposase_6_like

Family

11,769

true

false

This family of proteins includes enzymes that function as transposases, which are pivotal components in the movement of DNA segments known as insertion sequences. Transposases catalyze the cutting and rejoining of DNA strands, thereby facilitating the insertion of these sequences into new genomic locations. This mobili...

[]

0

[ "PANTHER" ]

[ "PTHR46637" ]

[ "Transposase_6_like" ]

[ 11769 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Paenibacillus phage Tripp", "unclassified sequences" ]

[ 96, 11573, 20, 2, 78 ]

5

[]

0

true

Family

Transposase_6_like

5

IPR052910

52,910

ABC Transporter and Purine-Binding

ABC-Purine-Binding

Family

8,374

true

false

This family of proteins includes ABC transporter components and purine-binding proteins. Members are involved in the import of glucose and purines such as adenine and guanine, suggesting a role in nutrient uptake. Some family members are part of ABC transporter complexes, which are critical for transporting various mol...

[]

0

[ "PANTHER" ]

[ "PTHR43208" ]

[ "ABC-Purine-Binding" ]

[ 8374 ]

1

[]

0

[ "3s99", "6pi5", "6pi6", "6pii" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Podoviridae sp. ctC2p8", "unclassified sequences" ]

[ 170, 7987, 25, 1, 191 ]

5

[]

0

true

Family

ABC Transporter and Purine-Binding

ABC-Purine-Binding

7

IPR052911

52,911

Corrinoid activation enzyme

Corrinoid_activation_enz

Family

6,056

true

false

This family of proteins is involved in the metabolic process of quaternary amine degradation, specifically L-proline betaine and L-carnitine. They function as part of a corrinoid-dependent methyltransferase system, which facilitates the transfer of a methyl group from these amines to tetrahydrofolate, producing methyl-...

[]

0

[ "PANTHER" ]

[ "PTHR42895" ]

[ "Corrinoid_activation_enz" ]

[ 6056 ]

1

[]

0

[ "3zyy", "4c1n" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 505, 5110, 3, 438 ]

4

[]

0

true

Family

Corrinoid activation enzyme

Corrinoid_activation_enz

9

IPR052912

52,912

UPF0111 domain-containing protein

UPF0111_domain

Family

9,104

true

false

This family of proteins may play a role in the transport of orthophosphate across the cell membrane. Members of this family are characterized by a conserved domain, denoted as UPF0111, which suggests a common structural framework or evolutionary origin. The precise biological functions of these proteins, beyond the pot...

[]

0

[ "PANTHER" ]

[ "PTHR37298" ]

[ "UPF0111_domain" ]

[ 9104 ]

1

[]

0

[ "3l39" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Kukulkanvirus", "metagenomes" ]

[ 128, 8835, 6, 2, 133 ]

5

[]

0

true

Family

UPF0111 domain-containing protein

UPF0111_domain

4

IPR052913

52,913

Glycopeptide antibiotic resistance protein

Glycopeptide_resist_protein

Family

9,767

true

false

This family of proteins includes those involved in antibiotic resistance, specifically resistance to glycopeptide antibiotics such as vancomycin. The family member VanW is known to confer resistance to vancomycin by an as yet not fully elucidated mechanism, which is believed to involve the remodeling of cell wall precu...

[]

0

[ "PANTHER" ]

[ "PTHR35788" ]

[ "Glycopeptide_resist_protein" ]

[ 9767 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 9625, 1, 141 ]

3

[]

0

true

Family

Glycopeptide antibiotic resistance protein

Glycopeptide_resist_protein

1

IPR052914

52,914

Aldehyde Oxidoreductase Iron-Sulfur Subunit

Aldehyde_Oxdr_Iron-Sulfur

Family

11,067

true

false

This family of proteins includes aldehyde oxidoreductase iron-sulfur-binding subunits that are involved in the oxidation of aldehydes into their corresponding carboxylic acids, with a particular affinity for aromatic aldehydes. These proteins are implicated in the cellular detoxification process, helping to mitigate po...

[]

0

[ "PANTHER" ]

[ "PTHR45331" ]

[ "Aldehyde_Oxdr_Iron-Sulfur" ]

[ 11067 ]

1

[]

0

[ "5g5g", "5g5h", "5y6q" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati", "metagenomes" ]

[ 10991, 4, 11, 61 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Aldehyde Oxidoreductase Iron-Sulfur Subunit

Aldehyde_Oxdr_Iron-Sulfur

6

IPR052915

52,915

RNA-splicing ligase RtcB-like

RtcB-like

Family

10,338

true

false

This family of proteins includes GTP-dependent RNA ligases that play a crucial role in RNA splicing and repair mechanisms. They are capable of joining RNA molecules with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Additionally, these proteins exhibit versatility by acting as DNA ligases to ...

[]

0

[ "PANTHER" ]

[ "PTHR43749" ]

[ "RtcB-like" ]

[ 10338 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 92, 9536, 320, 267, 123 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA-splicing ligase RtcB-like

RtcB-like

8

IPR052916

52,916

Type I Restriction Enzyme MTase Subunit

Type-I_RE_MTase_Subunit

Family

9,336

true

false

This family of proteins includes methyltransferase (MTase) subunits of type I restriction enzymes. These enzymes are multifunctional, with the ability to both modify and cleave DNA. The MTase activity involves methylation of adenosines within specific recognition sequences, which serves to protect the DNA from cleavage...

[]

0

[ "PANTHER" ]

[ "PTHR42998" ]

[ "Type-I_RE_MTase_Subunit" ]

[ 9336 ]

1

[ "EC" ]

[ "2.1.1.72" ]

[ "EC:2.1.1.72" ]

1

[ "3khk", "8w0p", "8w2p", "8w2q" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 209, 8879, 56, 5, 187 ]

5

[]

0

true

Family

Type I Restriction Enzyme MTase Subunit

Type-I_RE_MTase_Subunit

1

IPR052917

52,917

Stress Response and Developmental Protein

Stress-Dev_Protein

Family

10,365

true

false

This family of proteins includes members that are implicated in stress response and developmental processes. General stress proteins, such as GS26 from Bacillus subtilis, are typically induced under a variety of stress conditions and may confer protection against environmental stresses by stabilizing cellular proteins ...

[]

0

[ "PANTHER" ]

[ "PTHR34818" ]

[ "Stress-Dev_Protein" ]

[ 10365 ]

1

[]

0

[ "2fhq", "2hq7", "2i02", "2qea", "2re7", "3db0", "3dmb", "3ec6", "3u34", "3u35" ]

10

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 62, 8637, 1606, 60 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Stress Response and Developmental Protein

Stress-Dev_Protein

5

IPR052918

52,918

Motility and Chemotaxis Regulatory Protein

Motility_Chemotaxis_Reg

Family

5,219

true

false

This family of proteins includes members that are involved in the regulation of gene transcription related to motility and chemotaxis. One characterized member functions to modulate the transcription levels of flagellin and chemotaxis-related genes in a temporal manner, suggesting a role in the coordination of locomoti...

[]

0

[ "PANTHER" ]

[ "PTHR35580" ]

[ "Motility_Chemotaxis_Reg" ]

[ 5219 ]

1

[]

0

[ "7fh6", "7fh7", "7fh8", "7ron", "7roo" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 69, 4701, 266, 34, 149 ]

5

[]

0

true

Family

Motility and Chemotaxis Regulatory Protein

Motility_Chemotaxis_Reg

4

IPR052919

52,919

Type II TA system ribonuclease

TA_system_RNase

Family

6,309

true

false

This family of proteins includes ribonucleases that function as toxic components within type II toxin-antitoxin (TA) systems. Members of this family are capable of inhibiting translation and colony formation in certain bacterial species. Their RNase activity is typically counteracted by specific antitoxins, which neutr...

[]

0

[ "PANTHER" ]

[ "PTHR36173" ]

[ "TA_system_RNase" ]

[ 6309 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6206, 5, 98 ]

3

[]

0

true

Family

Type II TA system ribonuclease

TA_system_RNase

8

IPR052920

52,920

Potential DNA-binding regulatory protein

DNA-binding_regulatory

Family

10,381

true

false

This family of proteins includes members with potential regulatory functions, as suggested by one of its characterized members. However, the full spectrum of activities and roles within the family remains to be elucidated, as another member is currently uncharacterized. The family is likely involved in DNA-binding and ...

[]

0

[ "PANTHER" ]

[ "PTHR43358" ]

[ "DNA-binding_regulatory" ]

[ 10381 ]

1

[]

0

[ "5g59", "5g5c", "5g5m", "5lcn" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 62, 7006, 3265, 1, 47 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 22, 11, 26 ]

3

true

Family

Potential DNA-binding regulatory protein

DNA-binding_regulatory

1

IPR052921

52,921

G-protein Coupled Receptor 1 Superfamily Member

GPCR1_Superfamily_Member

Family

13,637

true

false

This family of proteins includes members that are part of the G-protein coupled receptor 1 superfamily. These receptors are typically involved in signal transduction processes and are known for their seven transmembrane helix structure. The family members are characterized by their ability to bind various ligands, whic...

[]

0

[ "PANTHER" ]

[ "PTHR26451" ]

[ "GPCR1_Superfamily_Member" ]

[ 13637 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 13637 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 166, 2, 8, 1 ]

4

true

Family

G-protein Coupled Receptor 1 Superfamily Member

GPCR1_Superfamily_Member

8

IPR052922

52,922

Cytidylate Kinase Type 2

Cytidylate_Kinase-2

Family

9,269

true

false

This family of proteins includes enzymes that are involved in nucleotide metabolism, specifically the phosphorylation of cytidine monophosphate (CMP) to cytidine diphosphate (CDP). These enzymes play a crucial role in the synthesis of nucleic acids by maintaining the cellular balance of nucleotides. They are characteri...

[]

0

[ "PANTHER" ]

[ "PTHR37816" ]

[ "Cytidylate_Kinase-2" ]

[ 9269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 42, 8829, 337, 61 ]

4

[]

0

true

Family

Cytidylate Kinase Type 2

Cytidylate_Kinase-2

9

IPR052924

52,924

OsmC/Ohr hydroperoxide reductase

OsmC/Ohr_hydroprdx_reductase

Family

7,371

true

false

The OsmC/Ohr family comprises proteins that function as hydroperoxide reductases, which are crucial for cellular defense against oxidative stress. Members of this family are involved in the reduction of both organic and inorganic peroxide substrates, thereby protecting cells from the damaging effects of reactive oxygen...

[]

0

[ "PANTHER" ]

[ "PTHR35368" ]

[ "OsmC/Ohr_hydroprdx_reductase" ]

[ 7371 ]

1

[]

0

[ "1lql", "2opl" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 423, 6313, 532, 103 ]

4

[]

0

true

Family

OsmC/Ohr hydroperoxide reductase

OsmC/Ohr_hydroprdx_reductase

7

IPR052925

52,925

Phage Integrase-like Recombinase

Phage_Integrase-like_Recomb

Family

10,892

true

false

This family of proteins includes enzymes that catalyze site-specific recombination events. Members are characterized by their ability to recognize and recombine specific DNA sequences, typically involving short conserved sequences. These proteins play key roles in the integration and excision of DNA segments, such as p...

[]

0

[ "PANTHER" ]

[ "PTHR34605" ]

[ "Phage_Integrase-like_Recomb" ]

[ 10892 ]

1

[]

0

[ "1crx", "1drg", "1f44", "1kbu", "1ma7", "1nzb", "1ouq", "1pvq", "1pvr", "1q3u", "1q3v", "1xns", "1xo0", "2crx", "3c28", "3c29", "3crx", "3mgv", "4crx", "5crx", "5u91", "7rhy", "7rhz" ]

23

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Heunggongvirae", "metagenomes" ]

[ 4741, 6089, 12, 50 ]

4

[ "Danio rerio" ]

[ 5 ]

1

true

Family

Phage Integrase-like Recombinase

Phage_Integrase-like_Recomb

4

IPR052926

52,926

Metallo-beta-lactamase domain-containing protein

Metallo-beta-lactamase_dom

Family

5,480

true

false

This family of proteins includes enzymes that belong to the metallo-beta-lactamase superfamily and are involved in the biosynthesis of cofactors. Specifically, they catalyze the condensation of 6-hydroxymethyl-7,8-dihydropterin pyrophosphate with 4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate to form a precursor in...

[]

0

[ "PANTHER" ]

[ "PTHR13754" ]

[ "Metallo-beta-lactamase_dom" ]

[ 5480 ]

1

[]

0

[ "2p4z", "3h3e", "7dck" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 578, 3818, 858, 226 ]

4

[]

0

true

Family

Metallo-beta-lactamase domain-containing protein

Metallo-beta-lactamase_dom

4

IPR052927

52,927

DCC thiol-disulfide oxidoreductase

DCC_oxidoreductase

Family

7,487

true

false

This family of proteins includes thiol-disulfide oxidoreductases that are involved in the formation, isomerization, and reduction of disulfide bonds. These enzymatic activities are crucial for protein folding and stability, and they play a significant role in various cellular processes including signal transduction, re...

[]

0

[ "PANTHER" ]

[ "PTHR33639" ]

[ "DCC_oxidoreductase" ]

[ 7487 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 177, 5785, 1467, 58 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 4, 9 ]

3

true

Family

DCC thiol-disulfide oxidoreductase

DCC_oxidoreductase

3

IPR052928

52,928

Uncharacterized desiccation-related membrane-associated

Desiccation-related_membrane

Family

6,219

true

false

This family of proteins includes uncharacterized members that are predicted to be associated with the membrane, as indicated by one of its members, YhaH from Bacillus subtilis. Another member, YtxH, also from Bacillus subtilis, shares similarity with a desiccation-related protein from Craterostigma plantagineum, sugges...

[]

0

[ "PANTHER" ]

[ "PTHR35792" ]

[ "Desiccation-related_membrane" ]

[ 6219 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6152, 8, 59 ]

3

[]

0

true

Family

Uncharacterized desiccation-related membrane-associated

Desiccation-related_membrane

9

IPR052929

52,929

RNase H-like EbsB-related

RNase_H-like_EbsB-rel

Family

17,517

true

false

This family of proteins includes members that are related to the RNase H family, specifically the EbsB subfamily. The proteins in this family are implicated in cellular processes involving the cell surface, such as the expression of receptors that facilitate mating aggregate formation. Although they share a common ance...

[]

0

[ "PANTHER" ]

[ "PTHR47074" ]

[ "RNase_H-like_EbsB-rel" ]

[ 17517 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 83, 17434 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 113, 63, 4 ]

3

true

Family

RNase H-like EbsB-related

RNase_H-like_EbsB-rel

2

IPR052930

52,930

Protein adenylyltransferase MntA

MntA

Family

4,392

true

This family of proteins includes Protein adenylyltransferase MntA which functions as antitoxins within type VII toxin-antitoxin (TA) systems. They neutralise the effects of cognate toxins through post-translational modifications, specifically by AMPylating the toxins. The AMPylation involves the addition of AMP to spec...

[]

0

[ "NCBIFAM", "PANTHER" ]

[ "NF047752", "PTHR43852" ]

[ "MntA_antitoxin", "TA_antitoxin_MntA" ]

[ 2839, 4190 ]

2

[]

0

[ "5yep", "6m6u", "6m6v", "6m6w", "7ae2", "7ae9", "7aer", "7bxo" ]

8

[ "PUB00097219", "PUB00097220", "PUB00097222" ]

[ "29555683", "33045733", "33290744" ]

[ "Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system.", "Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.", "HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutraliz...

[ 2018, 2020, 2020 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Russula earlei", "unclassified sequences" ]

[ 610, 3662, 1, 119 ]

4

[]

0

true

Family

Protein adenylyltransferase MntA

MntA

6

IPR052931

52,931

Prophage regulatory DNA-binding activator

Prophage_regulatory_activator

Family

8,087

true

false

This family of proteins includes transcriptional activators involved in the regulation of gene expression within cryptic prophage elements. Members of this family are known to positively regulate specific genes, such as the slpA gene, and can influence phenotypes related to capsule production and UV sensitivity. They a...

[]

0

[ "PANTHER" ]

[ "PTHR36154" ]

[ "Prophage_regulatory_activator" ]

[ 8087 ]

1

[]

0

[ "8c3t" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 7986, 15, 6, 80 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Prophage regulatory DNA-binding activator

Prophage_regulatory_activator

8

IPR052932

52,932

OprB Porin

OprB_Porin

Family

6,957

true

false

This family of proteins includes substrate-selective channels that facilitate the diffusion of compounds across cellular membranes. Members of this family are typically involved in the transport of small molecules, such as sugars and potentially other compounds with hydroxyl groups. Specific functions include the trans...

[]

0

[ "PANTHER" ]

[ "PTHR37944" ]

[ "OprB_Porin" ]

[ 6957 ]

1

[]

0

[ "4gey", "4gf4" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6907, 13, 37 ]

3

[]

0

true

Family

OprB Porin

OprB_Porin

6

IPR052933

52,933

DNA Protection and Modification

DNA_Protect_Modify

Family

9,544

true

false

This family of proteins includes members that are involved in the protection of DNA from host restriction-modification systems. They appear to function by preventing the degradation of DNA, particularly viral DNA, by host enzymes that recognize and cleave foreign DNA. Some family members are similar to type I restricti...

[]

0

[ "PANTHER" ]

[ "PTHR41313" ]

[ "DNA_Protect_Modify" ]

[ 9544 ]

1

[]

0

[ "2f8l" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanosarcina mazei", "unclassified sequences" ]

[ 9267, 34, 14, 1, 228 ]

5

[]

0

true

Family

DNA Protection and Modification

DNA_Protect_Modify

3

IPR052934

52,934

Methylated DNA Recognition and Restriction Enzymes

Methyl-DNA_Rec/Restrict_Enz

Family

7,213

true

false

This family of proteins includes enzymes involved in the recognition and processing of methylated DNA. Members of this family are capable of binding to DNA that contains methylated cytosines, which can be produced by various DNA methylases. Some proteins within this family recognize specific DNA sequences with methylat...

[]

0

[ "PANTHER" ]

[ "PTHR37291" ]

[ "Methyl-DNA_Rec/Restrict_Enz" ]

[ 7213 ]

1

[]

0

[ "6hz4", "6hz5", "6hz6", "6hz7", "6hz8", "6hz9", "6ut3", "6ut4", "6ut5", "6ut6", "6ut7", "6ut8", "7vsr" ]

13

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 477, 6639, 8, 4, 85 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Methylated DNA Recognition and Restriction Enzymes

Methyl-DNA_Rec/Restrict_Enz

1

IPR052935

52,935

Mg(2+)-dependent Phosphatidate Phosphatase

Mg2+_PAP

Family

8,454

true

false

The protein family includes Mg(2+)-dependent phosphatidate phosphatases that play a role in lipid metabolism by catalyzing the dephosphorylation of phosphatidate (PA) to produce diacylglycerol (DAG). This reaction is central to the synthesis of triglycerides and phospholipids. Members of the family may also be involved...

[]

0

[ "PANTHER" ]

[ "PTHR28208" ]

[ "Mg2+_PAP" ]

[ 8454 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4291, 4135, 28 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

Mg(2+)-dependent Phosphatidate Phosphatase

Mg2+_PAP

9

IPR052936

52,936

Jasmonate Hydroxylase-like

Jasmonate_Hydroxylase-like

Family

6,706

true

false

This family of proteins includes enzymes with monooxygenase activity that are involved in the modification of jasmonate, a plant hormone. Specifically, these proteins are capable of hydroxylating jasmonate to produce 12-hydroxyjasmonate, also known as tuberonic acid. This modification can influence plant innate immunit...

[]

0

[ "PANTHER" ]

[ "PTHR37811" ]

[ "Jasmonate_Hydroxylase-like" ]

[ 6706 ]

1

[]

0

[ "2go8" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 6494, 120, 16, 76 ]

4

[]

0

true

Family

Jasmonate Hydroxylase-like

Jasmonate_Hydroxylase-like

8

IPR052937

52,937

Inner membrane integral protein

Inner_membrane_protein

Family

7,055

true

false

This family of proteins is involved in the structural integrity and function of the inner membrane in bacteria. Members of this family are typically integral membrane proteins that may play a role in various cellular processes, including the transport of molecules across the membrane, signal transduction, or interactio...

[]

0

[ "PANTHER" ]

[ "PTHR42903" ]

[ "Inner_membrane_protein" ]

[ 7055 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6868, 140, 47 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane integral protein

Inner_membrane_protein

1

IPR052939

52,939

23S rRNA Guanine-N(1)-Methyltransferase RlmA

23S_rRNA_MeTrnsfrase_RlmA

Family

6,866

true

false

The RlmA family consists of enzymes that are involved in the post-transcriptional modification of bacterial ribosomal RNA. Members of this family are 23S rRNA methyltransferases, which specifically methylate guanosine at position 745 (G745) in 23S rRNA. This methylation is important for the proper function of the ribos...

[]

0

[ "PANTHER" ]

[ "PTHR43460" ]

[ "23S_rRNA_MeTrnsfrase_RlmA" ]

[ 6866 ]

1

[]

0

[ "1p91" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 4, 6785, 53, 24 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

23S rRNA Guanine-N(1)-Methyltransferase RlmA

23S_rRNA_MeTrnsfrase_RlmA

2

IPR052940

52,940

Carbohydrate Esterase 6

Carb_Esterase_6

Family

6,440

true

false

This family of proteins includes enzymes that are involved in the modification and metabolism of carbohydrates. Members of this family are characterized by their ability to catalyze reactions involving ester linkages in carbohydrate molecules. The functions of these enzymes are diverse, ranging from the hydrolysis of a...

[]

0

[ "PANTHER" ]

[ "PTHR31988" ]

[ "Carb_Esterase_6" ]

[ 6440 ]

1

[]

0

[ "1zmb", "2apj", "3pt5" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "unclassified sequences" ]

[ 3692, 2598, 10, 84, 56 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 15, 20 ]

4

true

Family

Carbohydrate Esterase 6

Carb_Esterase_6

2

IPR052941

52,941

Stomatal Development and Plant Interaction Regulator

StomDev_PlantInt_Reg

Family

2,727

true

false

This family of proteins is involved in diverse biological processes including development and interaction with symbiotic organisms. Members of this family play a crucial role in stomatal development, influencing cell fate progression, orientation of spacing divisions, and promoting asymmetric divisions in plant tissues...

[]

0

[ "PANTHER" ]

[ "PTHR48004" ]

[ "StomDev_PlantInt_Reg" ]

[ 2727 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 38, 2685, 4 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 13, 9 ]

3

true

Family

Stomatal Development and Plant Interaction Regulator

StomDev_PlantInt_Reg

9

IPR052943

52,943

TMTC O-mannosyl-transferase

TMTC_O-mannosyl-trnsfr

Family

6,233

true

false

This family of proteins includes O-mannosyl-transferases that are involved in the post-translational modification of proteins by transferring mannosyl residues to serine or threonine hydroxyl groups. Members of this family primarily modify the cadherin superfamily, adding O-linked mannose glycans in specific regions an...

[]

0

[ "PANTHER" ]

[ "PTHR44809" ]

[ "TMTC_O-mannosyl-trnsfr" ]

[ 6233 ]

1

[]

0

[ "5fzr", "5fzs" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 42, 3760, 2305, 126 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 3, 9 ]

4

true

Family

TMTC O-mannosyl-transferase

TMTC_O-mannosyl-trnsfr

6

IPR052944

52,944

Sporulation-related

Sporulation_related

Family

5,629

true

false

The protein family includes proteins such as the sporulation protein YdcC from Bacillus subtilis, which is required for efficient sporulation. While the function of the protein from Methanocaldococcus jannaschii remains uncharacterized, the presence of a homologous protein in a sporulation-capable bacterium suggests a ...

[]

0

[ "PANTHER" ]

[ "PTHR37507" ]

[ "Sporulation_related" ]

[ 5629 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 4911, 629, 1, 88 ]

4

[]

0

true

Family

Sporulation-related

Sporulation_related

1

IPR052945

52,945

Mitotic Progression Regulator

Mitotic_Regulator

Family

13,781

true

false

This family of proteins includes regulators of mitotic progression. Members of this family are known to interact with kinases involved in the phosphorylation of key mitotic regulators. Through these interactions, they can inhibit kinase activity, which in turn affects the phosphorylation state of proteins that control ...

[]

0

[ "PANTHER" ]

[ "PTHR43628" ]

[ "Mitotic_Regulator" ]

[ 13781 ]

1

[]

0

[ "6ork", "8z5n", "8z60" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomassiliicoccales", "Viruses", "metagenomes" ]

[ 6493, 7114, 8, 28, 138 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 1, 1 ]

4

true

Family

Mitotic Progression Regulator

Mitotic_Regulator

6

IPR052946

52,946

Alkaline pH Cation Antiporter

Alkaline_pH_Ca-Antiporter

Family

6,122

true

false

This family of proteins includes cation antiporters that primarily function in the exchange of sodium, potassium, and calcium ions across cellular membranes. Members of this family operate mainly at alkaline pH, where they can export sodium ions and facilitate the exchange of potassium and calcium ions for protons. Whi...

[]

0

[ "PANTHER" ]

[ "PTHR37958" ]

[ "Alkaline_pH_Ca-Antiporter" ]

[ 6122 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6078, 11, 33 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Alkaline pH Cation Antiporter

Alkaline_pH_Ca-Antiporter

7

IPR052948

52,948

Low temperature-induced all0457 homolog

Low_temp-induced_all0457

Family

4,358

true

false

This family of proteins is involved in the response to low temperature stress. The proteins are homologous to the all0457 protein, which suggests a potential role in cold adaptation mechanisms. The exact biological processes and molecular functions of these proteins remain to be characterized. However, based on their a...

[]

0

[ "PANTHER" ]

[ "PTHR36109" ]

[ "Low_temp-induced_all0457" ]

[ 4358 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "metagenomes" ]

[ 4310, 3, 6, 39 ]

4

[]

0

true

Family

Low temperature-induced all0457 homolog

Low_temp-induced_all0457

4

IPR052949

52,949

Peptide antibiotic immunity-related

PA_immunity-related

Family

6,133

true

false

This family of proteins includes members that are involved in providing immunity to certain peptide antibiotics, such as microcin B17, which targets DNA replication in Enterobacteriaceae. The proteins in this family can function in conjunction with others to induce the SOS repair system as a protective mechanism. Some ...

[]

0

[ "PANTHER" ]

[ "PTHR42999" ]

[ "PA_immunity-related" ]

[ 6133 ]

1

[]

0

[ "2w7z", "2xt2", "2xt4", "6fls" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 5767, 272, 41, 4, 49 ]

5

[]

0

true

Family

Peptide antibiotic immunity-related

PA_immunity-related

8

IPR052950

52,950

CDGSH iron-sulfur domain-containing protein

CISD

Family

3,882

true

false

This family of proteins is involved in the transfer of iron-sulfur clusters to apoferrodoxins, specifically FDX1 and FDX2, playing a critical role in mitochondrial iron homeostasis. Members of this family are essential for maintaining appropriate levels of free iron and reactive oxygen species within the mitochondria, ...

[]

0

[ "PANTHER" ]

[ "PTHR46491" ]

[ "CISD" ]

[ 3882 ]

1

[]

0

[ "3tbn", "6avj", "6z1p", "7w5z", "8b6h", "8bqs", "8gym", "8gzu", "9fq7", "9fq8", "9fzl" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 170, 1808, 1778, 126 ]

4

[ "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 1, 4, 7 ]

5

true

Family

CDGSH iron-sulfur domain-containing protein

CISD

9

IPR052951

52,951

Tellurite Resistance Ion Channel

Tellurite_res_ion_channel

Family

5,662

true

false

This family of proteins is involved in conferring resistance to potassium tellurite, a toxic compound. Members of this family function as ion channels that facilitate the transport processes associated with tellurite resistance. The activity of these proteins is essential for the survival of organisms in environments c...

[]

0

[ "PANTHER" ]

[ "PTHR37955" ]

[ "Tellurite_res_ion_channel" ]

[ 5662 ]

1

[]

0

[ "3m71", "3m72", "3m73", "3m74", "3m75", "3m76", "3m77", "3m78", "3m7b", "3m7c", "3m7e", "3m7l", "4ycr", "8en9", "8vi2", "8vi3", "8vi4", "8vi5" ]

18

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 21, 5540, 74, 27 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Tellurite Resistance Ion Channel

Tellurite_res_ion_channel

3

IPR052952

52,952

MFS-type Transporter

MFS-Transporter

Family

4,631

true

false

This family of proteins includes members that are part of the major facilitator superfamily (MFS), which is one of the largest groups of secondary transporters. Proteins in this family are involved in the transport of a diverse range of substrates across cellular membranes, including sugars, amino acids, ions, and drug...

[]

0

[ "PANTHER" ]

[ "PTHR23527" ]

[ "MFS-Transporter" ]

[ 4631 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 262, 4327, 4, 38 ]

4

[]

0

true

Family

MFS-type Transporter

MFS-Transporter

3

IPR052953

52,953

Serine-rich & Multicopper Oxidase-related

Ser-rich/MCO-related

Family

7,619

true

false

This family of proteins includes extracellular and membrane-anchored components with diverse functions. One member is characterized by a serine-rich extracellular region, suggesting a potential role in interactions with other proteins or cellular structures. Another member is a probable electron transfer copper protein...

[]

0

[ "PANTHER" ]

[ "PTHR34883" ]

[ "Ser-rich/MCO-related" ]

[ 7619 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Tahibacter aquaticus" ]

[ 7618, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 5 ]

1

true

Family

Serine-rich & Multicopper Oxidase-related

Ser-rich/MCO-related

3

IPR052954

52,954

GPCR_Ligand_Interaction

GPCR-Ligand_Int

Family

11,836

true

false

This family of proteins includes G-protein coupled receptors (GPCRs) that interact with specific ligands to regulate various biological processes. Members of this family are involved in the recognition and response to peptide or pheromone signals, which can influence neuronal excitability, behavior, and developmental p...

[]

0

[ "PANTHER" ]

[ "PTHR46641" ]

[ "GPCR-Ligand_Int" ]

[ 11836 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 11836 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 22, 10 ]

2

true

Family

GPCR_Ligand_Interaction

GPCR-Ligand_Int

1

IPR052955

52,955

UPF0703 two-component membrane permease

UPF0703_membrane_permease

Family

4,736

true

false

The UPF0703 family includes proteins that may function in amino acid transport, particularly under low pH conditions. Members of the UPF0703 family are implicated in processes such as acidogenesis, biofilm formation, and survival in acidic environments. Although the specific roles of these proteins can vary, the family...

[]

0

[ "PANTHER" ]

[ "PTHR40047" ]

[ "UPF0703_membrane_permease" ]

[ 4736 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4711, 2, 23 ]

3

[]

0

true

Family

UPF0703 two-component membrane permease

UPF0703_membrane_permease

7

IPR052956

52,956

Mesenchyme-associated surface protein

Mesenchyme-surface_protein

Family

4,805

true

false

This family of proteins includes members that may play roles in cellular processes such as migration, adhesion, fusion, or formation of skeletal structures. The specific functions of these proteins are not well characterized, but they are suggested to be involved in the organization and dynamics of mesenchyme-derived t...

[]

0

[ "PANTHER" ]

[ "PTHR46928" ]

[ "Mesenchyme-surface_protein" ]

[ 4805 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Kyanoviridae", "Methanobacteriati", "metagenomes" ]

[ 4203, 535, 3, 29, 35 ]

5

[]

0

true

Family

Mesenchyme-associated surface protein

Mesenchyme-surface_protein

6

IPR052958

52,958

Interferon-induced PKR regulator

IFN-induced_PKR_regulator

Family

7,022

true

false

This family of proteins acts as upstream regulators of interferon-induced serine/threonine protein kinase R (PKR). They are involved in the modulation of PKR activity by potentially interfering with the inhibitory function of DNAJC3, a known regulator of PKR. Through this interaction, these proteins may play a role in ...

[]

0

[ "PANTHER" ]

[ "PTHR46289" ]

[ "IFN-induced_PKR_regulator" ]

[ 7022 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 7022 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 5, 11, 13, 4, 1 ]

5

true

Family

Interferon-induced PKR regulator

IFN-induced_PKR_regulator

7

IPR052959

52,959

Inner membrane-associated protein

Inner_membrane_assoc

Family

4,587

true

false

This family of proteins is involved in the cellular processes occurring in the inner membrane of bacterial cells. The specific functions of these proteins, however, are not well characterized. They may play a role in various membrane-associated activities, such as transport, signaling, or maintaining the integrity and ...

[]

0

[ "PANTHER" ]

[ "PTHR38598" ]

[ "Inner_membrane_assoc" ]

[ 4587 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "GOM Arc I cluster", "metagenomes" ]

[ 4557, 4, 3, 23 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane-associated protein

Inner_membrane_assoc

6

IPR052960

52,960

Glucosamine-6-phosphate deaminase-like

GlcN6P_deaminase-like

Family

3,796

true

false

This family of proteins includes enzymes that catalyze the reversible isomerization-deamination of glucosamine 6-phosphate to fructose 6-phosphate and ammonium ion. Members of this family are involved in amino sugar metabolism, specifically in the conversion of glucosamine-6-phosphate, a derivative of glucose and an in...

[]

0

[ "PANTHER" ]

[ "PTHR42892" ]

[ "GlcN6P_deaminase-like" ]

[ 3796 ]

1

[]

0

[ "6nbg" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_83_G03" ]

[ 3529, 146, 120, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glucosamine-6-phosphate deaminase-like

GlcN6P_deaminase-like

4

IPR052961

52,961

Oxidoreductase and Kinase-like Enzymes

Oxido-Kinase-like_Enzymes

Family

4,543

true

false

This family of proteins includes enzymes with diverse catalytic activities. One member is an oxidoreductase belonging to the short-chain dehydrogenases/reductases (SDR) family, which typically function in the NAD(P)(H)-dependent metabolism of steroids, alcohols, and lipids. Another member is akin to the choline/ethanol...

[]

0

[ "PANTHER" ]

[ "PTHR23020" ]

[ "Oxido-Kinase-like_Enzymes" ]

[ 4543 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1327, 3160, 56 ]

3

[ "Caenorhabditis elegans" ]

[ 38 ]

1

true

Family

Oxidoreductase and Kinase-like Enzymes

Oxido-Kinase-like_Enzymes

6

IPR052962

52,962

Amino Acid Transporter AGT Superfamily

AA_Transporter_AGT

Family

4,650

true

false

This family of proteins includes transporters that are involved in the uptake of specific amino acids. Members of this family are characterized by their ability to transport glutamate and serine, with one member being a major transporter for these amino acids under certain growth conditions. Another member of the famil...

[]

0

[ "PANTHER" ]

[ "PTHR47547" ]

[ "AA_Transporter_AGT" ]

[ 4650 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 286, 4316, 4, 44 ]

4

[]

0

true

Family

Amino Acid Transporter AGT Superfamily

AA_Transporter_AGT

8

IPR052963

52,963

Phosphopantetheine Phosphodiesterase

Pantetheine_PDE

Family

5,023

true

false

This family of proteins includes enzymes with phosphodiesterase activity, specifically involved in the hydrolysis of the phosphopantetheine group from holo-carrier proteins. Members of this family are characterized by their role in the modification of carrier proteins, which is a critical step in various metabolic proc...

[]

0

[ "PANTHER" ]

[ "PTHR36492" ]

[ "Pantetheine_PDE" ]

[ 5023 ]

1

[]

0

[ "6unc" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "ecological metagenomes" ]

[ 3617, 2, 1396, 8 ]

4

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 10 ]

2

true

Family

Phosphopantetheine Phosphodiesterase

Pantetheine_PDE

2

IPR052965

52,965

Pigment-associated catalase-like

Pigment-catalase-like

Family

4,945

true

false

This family of proteins includes members that are involved in the protection and stabilization of specific pigments. One known function is the facilitation of pigment formation through the condensation of specific aldehydes and amino acids, resulting in compounds with stable imine bonds. These pigments serve as visual ...

[]

0

[ "PANTHER" ]

[ "PTHR31694" ]

[ "Pigment-catalase-like" ]

[ 4945 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 1332, 3516, 93, 4 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 1, 10, 13 ]

4

true

Family

Pigment-associated catalase-like

Pigment-catalase-like

3

IPR052966

52,966

Beta-lactamase Regulatory Protein

Beta-lactamase_Reg

Family

3,914

true

false

This family of proteins includes putative signaling proteins that are implicated in the regulation of beta-lactamase. Members of this family are not believed to directly sense beta-lactams but may play a role in the signaling pathways that control the expression of beta-lactamase, an enzyme responsible for antibiotic r...

[]

0

[ "PANTHER" ]

[ "PTHR38684" ]

[ "Beta-lactamase_Reg" ]

[ 3914 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3872, 2, 40 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Beta-lactamase Regulatory Protein

Beta-lactamase_Reg

8

IPR052967

52,967

Stress Response-Associated Protein

Stress_Response_Assoc

Family

4,577

true

false

This family of proteins includes members that are involved in cellular stress response mechanisms. The protein YsnF from Bacillus subtilis is known to be associated with stress response, suggesting a role in the adaptation or protection of the cell under stress conditions. The function of the protein DR_1314 from Deino...

[]

0

[ "PANTHER" ]

[ "PTHR38463" ]

[ "Stress_Response_Assoc" ]

[ 4577 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Nitrososphaeraceae", "Viridiplantae", "ecological metagenomes" ]

[ 4545, 9, 9, 14 ]

4

[]

0

true

Family

Stress Response-Associated Protein

Stress_Response_Assoc

5

IPR052969

52,969

Threonine-specific kinase-like protein

Thr-specific_kinase-like

Family

4,549

true

false

This family of proteins includes members that exhibit kinase activity, with a preference for phosphorylating threonine residues over serine. They may play a role in the regulation of cytoskeletal elements, such as myosin II, particularly during cell division processes like cytokinesis. Some family members are capable o...

[]

0

[ "PANTHER" ]

[ "PTHR47763" ]

[ "Thr-specific_kinase-like" ]

[ 4549 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 15, 1588, 2894, 23, 29 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Threonine-specific kinase-like protein

Thr-specific_kinase-like

5

IPR052970

52,970

Inner ear hair cell lipoxygenase homology domain-containing protein

Inner_ear_hair_cell_LOXHD

Family

5,084

true

false

This family of proteins includes members that are essential for the proper functioning of hair cells in the inner ear, which are critical for the process of hearing. They are characterized by the presence of a lipoxygenase homology domain, which suggests a role in lipid metabolism or signaling pathways related to senso...

[]

0

[ "PANTHER" ]

[ "PTHR45901" ]

[ "Inner_ear_hair_cell_LOXHD" ]

[ 5084 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanococcus voltae" ]

[ 97, 4982, 5 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 17, 5, 6 ]

5

true

Family

Inner ear hair cell lipoxygenase homology domain-containing protein

Inner_ear_hair_cell_LOXHD

9

IPR052971

52,971

Transient receptor potential calcium channel

TRP_calcium_channel

Family

5,621

true

false

This family of proteins includes calcium channels that are essential for the regulated release of calcium ions from intracellular stores in response to various stimuli. Members of this family are involved in cellular processes such as response to hyperosmotic shock and stress conditions. They play a crucial role in mai...

[]

0

[ "PANTHER" ]

[ "PTHR35859" ]

[ "TRP_calcium_channel" ]

[ 5621 ]

1

[ "REACTOME" ]

[ "R-SCE-3295583" ]

[ "REACTOME:R-SCE-3295583" ]

1

[ "6whg" ]

1

[]

0

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 5620, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 5, 1 ]

2

true

Family

Transient receptor potential calcium channel

TRP_calcium_channel

2

IPR052972

52,972

Sacsin chaperone regulator

Sacsin_chaperone_reg

Family

5,177

true

false

The Sacsin protein family includes co-chaperones that regulate the Hsp70 chaperone machinery. Members of this family are involved in the processing of proteins linked to ataxia, a neurological disorder affecting coordination. Sacsin proteins contain a functional J domain that stimulates ATPase activity of bacterial dna...

[]

0

[ "PANTHER" ]

[ "PTHR15600" ]

[ "Sacsin_chaperone_reg" ]

[ 5177 ]

1

[]

0

[ "5v44", "5v45", "5v46", "5v47" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 101, 5075, 1 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 3, 14, 6, 8, 7, 23 ]

7

true

Family

Sacsin chaperone regulator

Sacsin_chaperone_reg

2

IPR052973

52,973

Transcription factor kpeA/SAT20-like

KpeA/SAT20-like

Family

5,351

false

This entry represents a family of transcription factors from ascomycetes, including Satratoxin biosynthesis SC3 cluster transcription factor SAT20 from Stachybotrys chartarum and Transcription factor kpeA from Aspergillus oryzae. KpeA regulates kojic acid production by negatively controlling kojR and kojA expression an...

[]

0

[ "PANTHER" ]

[ "PTHR35392" ]

[ "" ]

[ 5351 ]

1

[]

0

[]

0

[ "PUB00087317", "PUB00162118" ]

[ "25015739", "30790620" ]

[ "Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys.", "A unique Zn(II)<sub>2</sub>-Cys<sub>6</sub>-type protein, KpeA, is involved in secondary metabolism and conidiation in Aspergillus oryzae." ]

[ 2014, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5351 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 9 ]

1

true

Family

Transcription factor kpeA/SAT20-like

KpeA/SAT20-like

4

IPR052974

52,974

Glycosyl Hydrolase 79 Enzymes

GH79_Enzymes

Family

5,080

true

false

This family of proteins includes enzymes with beta-glucuronidase activity, which are involved in the hydrolysis of beta-glucuronosyl and 4-O-methyl-beta-glucuronosyl residues of arabinogalactan-protein. These enzymes exhibit very weak hydrolysis of heparan sulfate and no activity on birchwood xylan. They are also capab...

[]

0

[ "PANTHER" ]

[ "PTHR36183" ]

[ "GH79_Enzymes" ]

[ 5080 ]

1

[]

0

[ "3vny", "3vnz", "3vo0", "5bwi", "5g0m", "5g0q", "5l77", "7dfq", "7dfs", "7pr9", "7prb", "7psh", "7psi", "7psj", "7psk", "8b0d", "8b0e", "8ogx", "8oht", "8ohu", "8ohv", "8ohw" ]

22

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 374, 4705, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Glycosyl Hydrolase 79 Enzymes

GH79_Enzymes

2

IPR052975

52,975

Repressor-like protein SSo7c3-like

SSo7c3-like

Family

2,185

true

This represents repressor-like proteins SSo7c4 and SSo7c3 in prokaryotes. Members of this family may bind to DNA and modulate the transcription of various genes. They could interact with specific DNA sequences, acting as transcriptional repressors or activators depending on the context. These proteins may play a role i...

[]

0

[ "PANTHER" ]

[ "PTHR34860" ]

[ "Repressor-like_regulatory" ]

[ 2185 ]

1

[]

0

[ "2glw", "2l66", "5itj", "5itm" ]

4

[ "PUB00161739" ]

[ "9720912" ]

[ "Isolation and structure of repressor-like proteins from the archaeon Sulfolobus solfataricus. Co-purification of RNase A with Sso7c." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacillus phage BCD7", "Bacteria", "metagenomes" ]

[ 996, 1, 1119, 69 ]

4

[]

0

true

Family

Repressor-like protein SSo7c3-like

SSo7c3-like

4

IPR052976

52,976

Scoloptoxin-like

Family

5,832

true

false

This family of proteins includes neurotoxins known as scoloptoxins. These toxins are typically found in the venom of scorpions and are characterized by their ability to interfere with ion channel function, particularly sodium channels. By binding to these channels, scoloptoxins can disrupt normal neuronal signaling, le...

[]

0

[ "PANTHER" ]

[ "PTHR22933" ]

[ "Scoloptoxin-like" ]

[ 5832 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "White spot syndrome virus" ]

[ 5814, 4, 14 ]

3

[ "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 32, 1 ]

2

true

Family

Scoloptoxin-like

7

IPR052977

52,977

Polyferredoxin-like electron transfer protein

Polyferredoxin-like_ET

Family

2,201

true

false

This family of proteins includes polyferredoxins, which are iron-sulfur proteins involved in electron transfer processes. Polyferredoxins typically contain multiple iron-sulfur clusters that facilitate the transfer of electrons within cellular redox reactions. These proteins play a crucial role in various metabolic pat...

[]

0

[ "PANTHER" ]

[ "PTHR43193" ]

[ "Polyferredoxin-like_ET" ]

[ 2201 ]

1

[]

0

[ "5t5i", "5t5m", "5t61", "7bkb", "7bkc" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 375, 1759, 67 ]

3

[]

0

true

Family

Polyferredoxin-like electron transfer protein

Polyferredoxin-like_ET

9

IPR052978

52,978

Glyceraldehyde-3-phosphate dehydrogenase

GAP_dehydrogenase

Family

2,677

true

false

This family of proteins includes enzymes that are essential for the glycolytic pathway. They are responsible for the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate, a reaction that involves the use of NAD as a cofactor. Initially, a hemiacetal intermediate is formed between the substrate and a cyst...

[]

0

[ "PANTHER" ]

[ "PTHR42955" ]

[ "GAP_dehydrogenase" ]

[ 2677 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2493, 132, 52 ]

3

[]

0

true

Family

Glyceraldehyde-3-phosphate dehydrogenase

GAP_dehydrogenase

7

IPR052979

52,979

Adenylate-forming domain-containing protein

Adenylate-forming_domain

Family

4,625

true

false

This family of proteins includes enzymes that are involved in natural product biosynthesis, functioning similarly to non-ribosomal peptide synthetases. They are characterized by their ability to modify a single substrate rather than condensing multiple building blocks. Members of this family contain three distinct doma...

[]

0

[ "PANTHER" ]

[ "PTHR33927" ]

[ "Adenylate-forming_domain" ]

[ 4625 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 367, 4257, 1 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 1, 2 ]

4

true

Family

Adenylate-forming domain-containing protein

Adenylate-forming_domain

4

IPR052980

52,980

Crinkler effector

Crinkler_effector

Family

4,607

true

false

This family of proteins includes secreted effectors known to induce necrosis in host plants, which is a typical response of plant innate immunity. Members of this family possess a modular structure characterized by a signal peptide, a conserved N-terminal region, and variable C-terminal domains. The N-terminal region c...

[]

0

[ "PANTHER" ]

[ "PTHR33129" ]

[ "Crinkler_effector" ]

[ 4607 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4607 ]

1

[]

0

true

Family

Crinkler effector

Crinkler_effector

6

IPR052981

52,981

Ingression C2 domain-containing protein

Ingression_C2_domain

Family

4,507

true

false

This family of proteins is involved in cytokinesis, the process where the cytoplasm of a eukaryotic cell divides to form two daughter cells. Members of this family play a role in the ingression of the plasma membrane during this process, which is crucial for the separation of the daughter cells. They may also influence...

[]

0

[ "PANTHER" ]

[ "PTHR47052" ]

[ "Ingression_C2_domain" ]

[ 4507 ]

1

[]

0

[ "1gmi" ]

1

[]

0

[]

0

null

[ "Eukaryota", "Streptomyces avidinii" ]

[ 4506, 1 ]

2

[ "Arabidopsis thaliana", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 1, 1, 3, 1, 1, 3 ]

8

true

Family

Ingression C2 domain-containing protein

Ingression_C2_domain

3

IPR052982

52,982

SRP1/TIP1-like Cell Wall Component

SRP1/TIP1-like

Family

4,263

true

false

This family of proteins includes members that are likely involved in the structure and integrity of the cell wall. They are characterized by similarity to the SRP1/TIP1 family, which suggests a role in cellular processes related to the cell wall. The exact functions of these proteins may vary, but one of the proteins i...

[]

0

[ "PANTHER" ]

[ "PTHR40633" ]

[ "SRP1/TIP1-like" ]

[ 4263 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 4, 20, 4220, 19 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 1, 1, 1 ]

3

true

Family

SRP1/TIP1-like Cell Wall Component

SRP1/TIP1-like

3

IPR052983

52,983

Major Facilitator Superfamily Riboflavin Transporter

MFS_Riboflavin_Transporter

Family

5,361

true

false

This family of proteins is involved in the cellular uptake of riboflavin, also known as vitamin B2, which is an essential nutrient for many organisms. Members of this family are capable of transporting not only riboflavin but also its derivatives, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), acros...

[]

0

[ "PANTHER" ]

[ "PTHR43385" ]

[ "MFS_Riboflavin_Transporter" ]

[ 5361 ]

1

[]

0

[ "8hpj", "8hpk" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 115, 2837, 2315, 94 ]

4

[ "Caenorhabditis elegans" ]

[ 4 ]

1

true

Family

Major Facilitator Superfamily Riboflavin Transporter

MFS_Riboflavin_Transporter

2

IPR052984

52,984

UPF0421

Family

3,465

true

false

This family of proteins is classified under the UPF0421 family, which is a group of uncharacterized proteins. Due to the lack of specific functional information, the precise biological roles of these proteins remain unknown. Typically, proteins grouped in such families are identified based on sequence similarities and ...

[]

0

[ "PANTHER" ]

[ "PTHR40064" ]

[ "UPF0421" ]

[ 3465 ]

1

[]

0

[ "3kmi" ]

1

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3455, 6, 4 ]

3

[]

0

true

Family

UPF0421

2

IPR052985

52,985

CoA-transferase III family involved in biosynthesis and detoxification

CoA-trans_III_biosynth/detox

Family

3,618

true

false

The CoA-transferase III family is involved in diverse biosynthetic and degradation pathways. One member, Acetyl-coenzyme A transferase nodX, is crucial in the biosynthesis of indole diterpenes nodulisporic acids, which have potent insecticidal properties without adverse effects on mammals. It participates in multiple s...

[]

0

[ "PANTHER" ]

[ "PTHR48229" ]

[ "CoA-trans_III_biosynth/detox" ]

[ 3618 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Pyrobaculum aerophilum", "unclassified sequences" ]

[ 737, 2854, 3, 24 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

CoA-transferase III family involved in biosynthesis and detoxification

CoA-trans_III_biosynth/detox

3

IPR052986

52,986

Interferon-induced very large GTPase

VLIG_GTPase

Family

2,781

true

false

This family of proteins is characterized by GTPase activity and is implicated in cellular processes that are induced by interferon. Members of this family are part of the TRAFAC class dynamin-like GTPase superfamily and are known for their large size. These GTPases are involved in the immune response and may play a rol...

[]

0

[ "PANTHER" ]

[ "PTHR14819" ]

[ "VLIG_GTPase" ]

[ 2781 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae", "Eukaryota" ]

[ 4, 2777 ]

2

[ "Danio rerio", "Mus musculus" ]

[ 5, 2 ]

2

true

Family

Interferon-induced very large GTPase

VLIG_GTPase

5

IPR052987

52,987

Chloroplastic ATP-dependent AMP-binding Enzymes

Chloroplast_AMP-bd_Enzymes

Family

2,785

true

false

The ATP-dependent AMP-binding enzyme family is involved in the activation of fatty acids to acyl-carrier-protein (ACP), a crucial step in fatty acid metabolism. Members of this family, such as the probable acyl-activating enzyme 16 and the long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, both chloroplastic e...

[]

0

[ "PANTHER" ]

[ "PTHR43813" ]

[ "Chloroplast_AMP-bd_Enzymes" ]

[ 2785 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 1346, 1395, 3, 41 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 6, 11 ]

3

true

Family

Chloroplastic ATP-dependent AMP-binding Enzymes

Chloroplast_AMP-bd_Enzymes

1

IPR052988

52,988

Oryzine biosynthesis lactonohydrolase

Oryzine_lactonohydrolase

Family

4,016

true

false

This family of proteins includes lactonohydrolases involved in the biosynthesis of oryzines, which are natural products with a unique maleidride backbone. These enzymes participate in a multi-step pathway that begins with the formation of octenoic acid by a fungal fatty acid synthase. The acid is then activated and con...

[]

0

[ "PANTHER" ]

[ "PTHR47064" ]

[ "Oryzine_lactonohydrolase" ]

[ 4016 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 42, 3971, 3 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Oryzine biosynthesis lactonohydrolase

Oryzine_lactonohydrolase

8

IPR052989

52,989

Mg-chelatase D/I-like

Mg-chelatase_DI-like

Family

6,383

true

false

This family of proteins is involved in the process of magnesium chelation, which is a critical step in the biosynthesis of chlorophyll. Members of this family are part of the Mg-chelatase enzyme complex, which catalyzes the insertion of a magnesium ion into protoporphyrin IX, a precursor of chlorophyll and heme. The ac...

[]

0

[ "PANTHER" ]

[ "PTHR35023" ]

[ "Mg-chelatase_DI-like" ]

[ 6383 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 427, 5883, 25, 48 ]

4

[]

0

true

Family

Mg-chelatase D/I-like

Mg-chelatase_DI-like

8

IPR052990

52,990

Sulfoquinovosidase Glycosyl Hydrolase

Sulfoquinovosidase_GH31

Family

2,967

true

false

The glycosyl hydrolase 31 family is involved in the degradation of sulfoquinovosyl diacylglycerides (SQDG) and sulfoquinovosyl glycerol (SQGro), releasing sulfoquinovose (SQ) which is utilized as a source of carbon and sulfur. In E. coli, SQ is further degraded through the SQ-EMP sulfoglycolysis pathway. The family inc...

[]

0

[ "PANTHER" ]

[ "PTHR46959" ]

[ "Sulfoquinovosidase_GH31" ]

[ 2967 ]

1

[]

0

[ "5aed", "5aee", "5aeg", "5ohs", "5oht", "5ohy", "6pnr", "7ofx", "8r56" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 2, 1799, 1144, 22 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 1, 4, 4 ]

3

true

Family

Sulfoquinovosidase Glycosyl Hydrolase

Sulfoquinovosidase_GH31

5