LiteFold/InterPro · Datasets at Hugging Face

IPR052992

52,992

Short-chain dehydrogenases/reductases member 12

SDR_member_12

Family

3,247

true

false

This family of proteins includes members that are putative oxidoreductases, suggesting a role in catalyzing redox reactions. These proteins are characterized by their membership in the short-chain dehydrogenases/reductases (SDR) family, which is known for its involvement in the metabolism of a wide variety of compounds...

[]

0

[ "PANTHER" ]

[ "PTHR44656" ]

[ "SDR_member_12" ]

[ 3247 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina horonobensis HB-1 = JCM 15518", "metagenomes" ]

[ 566, 2619, 1, 61 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 5, 3, 3, 5 ]

5

true

Family

Short-chain dehydrogenases/reductases member 12

SDR_member_12

5

IPR052993

52,993

Cilia- and flagella-associated protein 57

CFA-57

Family

3,700

true

false

This family of proteins is associated with the structure and function of cilia and flagella, which are hair-like organelles protruding from the cell surface. These organelles are critical for movement and sensory functions in many eukaryotic cells. Proteins in this family are believed to play a role in the assembly, ma...

[]

0

[ "PANTHER" ]

[ "PTHR32215" ]

[ "CFA-57" ]

[ 3700 ]

1

[]

0

[ "8glv", "8j07", "8tid", "9d2f", "9e5c", "9fqr" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8, 3690, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 5, 5, 1, 5 ]

6

true

Family

Cilia- and flagella-associated protein 57

CFA-57

8

IPR052994

52,994

Tiny macrocysts signaling regulators

Tiny_macrocysts_regulators

Family

3,177

true

false

This family of proteins includes regulators of the cAMP signaling pathway that are specific to sexual development in certain eukaryotic organisms. Members of this family are involved in controlling the levels of extracellular cAMP, which is a key second messenger in many biological processes. They achieve this by influ...

[]

0

[ "PANTHER" ]

[ "PTHR31600" ]

[ "Tiny_macrocysts_regulators" ]

[ 3177 ]

1

[]

0

[ "1d06", "1dp6", "1dp8", "1dp9", "1drm", "1ew0", "1lsv", "1lsw", "1lsx", "1lt0", "1xj2", "1xj3", "1xj4", "1xj6", "1y28", "2cmn", "2owh", "2owj", "2vv6", "2vv7", "2vv8" ]

21

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 63, 3109, 2, 3 ]

4

[]

0

true

Family

Tiny macrocysts signaling regulators

Tiny_macrocysts_regulators

7

IPR052995

52,995

Low molecular weight protein-tyrosine-phosphatase

LMW-PTP

Family

2,196

true

false

This family of proteins includes enzymes that function as phosphatases, specifically targeting phosphotyrosine residues. Members of this family are characterized by their ability to dephosphorylate tyrosine-phosphorylated proteins, which is a critical step in reversing the phosphorylation events that occur in signal tr...

[]

0

[ "PANTHER" ]

[ "PTHR47439" ]

[ "LMW-PTP" ]

[ 2196 ]

1

[]

0

[ "3ido", "3ily", "3js5", "3jvi", "5o7b" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1393, 767, 36 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 3, 14 ]

3

true

Family

Low molecular weight protein-tyrosine-phosphatase

LMW-PTP

8

IPR052996

52,996

Carbohydrate Metabolism Mutarotase

Carb_Metab_Mutarotase

Family

2,329

true

false

This family of proteins includes enzymes involved in carbohydrate metabolism. Members of this family are known to participate in the catabolism of sugars such as L-fucose, and are capable of catalyzing the anomeric conversion of specific sugar isomers. The enzymes may exhibit activity towards various pyranosides, inclu...

[]

0

[ "PANTHER" ]

[ "PTHR43239" ]

[ "Carb_Metab_Mutarotase" ]

[ 2329 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2247, 52, 30 ]

3

[]

0

true

Family

Carbohydrate Metabolism Mutarotase

Carb_Metab_Mutarotase

1

IPR052997

52,997

RRT15-like

Family

5,902

false

This entry includes Regulator of rDNA transcription protein 15 (RRT15) from yeast, which is involved in the modulation of rDNA transcription [ ]. Members of this family are characterised by their role in the regulation of ribosomal DNA transcription, which is a critical process for ribosome biogenesis and cell growth. ...

[]

0

[ "PANTHER" ]

[ "PTHR33047" ]

[ "" ]

[ 5902 ]

1

[]

0

[]

0

[ "PUB00075791", "PUB00155062" ]

[ "19270272", "24374639" ]

[ "Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae.", "The reference genome sequence of Saccharomyces cerevisiae: then and now." ]

[ 2009, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Haloarcula pellucida", "marine metagenome" ]

[ 19, 5881, 1, 1 ]

4

[ "Arabidopsis thaliana", "Homo sapiens", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 1, 1, 1, 2, 2 ]

5

true

Family

RRT15-like

2

IPR052998

52,998

Hetero-Diels-Alderase-like

Family

3,601

true

false

This family of proteins includes enzymes that are putative hetero-Diels-Alderase, which are involved in the biosynthesis of complex meroterpenoids. These enzymes are thought to catalyze the key step of linking a polyketide moiety with a terpene component, such as humulene or its derivatives, to form a distinctive tropo...

[]

0

[ "PANTHER" ]

[ "PTHR42060" ]

[ "Hetero-Diels-Alderase-like" ]

[ 3601 ]

1

[]

0

[ "2p4o", "7x2n", "7x2s", "7x2x", "7x36" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales" ]

[ 568, 3023, 10 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Hetero-Diels-Alderase-like

8

IPR052999

52,999

Peroxisomal Targeting Signal 1 Protein

PTS1_Protein

Family

3,541

true

false

This family of proteins is likely involved in the biogenesis and maintenance of peroxisomes, cellular organelles that play a crucial role in the metabolism of specific fatty acids and the detoxification of reactive oxygen species. Members of this family may also participate in amino acid metabolism. They are characteri...

[]

0

[ "PANTHER" ]

[ "PTHR28180" ]

[ "PTS1_Protein" ]

[ 3541 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 6, 3534, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Peroxisomal Targeting Signal 1 Protein

PTS1_Protein

8

IPR053000

53,000

DNA-dependent metalloprotease WSS1-like

WSS1-like_metalloprotease

Family

3,860

true

false

This family of proteins includes metalloendopeptidases that selectively target DNA-binding proteins in the presence of DNA, which facilitates the interaction between the protease and its substrates. These enzymes play a critical role in the repair of toxic DNA-protein cross-links (DPCs), such as those formed by trapped...

[]

0

[ "PANTHER" ]

[ "PTHR46622" ]

[ "WSS1-like_metalloprotease" ]

[ 3860 ]

1

[]

0

[ "5xbn", "5xbv" ]

2

[]

0

[]

0

null

[ "Eukaryota", "metagenomes" ]

[ 3858, 2 ]

2

[ "Arabidopsis thaliana", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 2, 1, 1, 3, 1, 1, 7 ]

8

true

Family

DNA-dependent metalloprotease WSS1-like

WSS1-like_metalloprotease

5

IPR053001

53,001

MNNG export permease-like

MNNG_permease-like

Family

3,178

true

false

This family of proteins includes members that may function in the cellular response to alkylating agents. One characterized member is suggested to act as an export permease for N-methyl-N'nitro-N-nitrosoguanidine (MNNG), a mutagenic and carcinogenic chemical. The proteins in this family are also noted for their similar...

[]

0

[ "PANTHER" ]

[ "PTHR34814" ]

[ "MNNG_permease-like" ]

[ 3178 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3178 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Family

MNNG export permease-like

MNNG_permease-like

9

IPR053002

53,002

Zinc-dependent metalloproteinase M10B

Metalloproteinase_M10B

Family

3,287

true

false

This family of proteins includes zinc-dependent metalloproteinases, which are part of the peptidase M10B subfamily. These enzymes are characterized by their ability to cleave peptide bonds in various protein substrates, a process essential for numerous biological functions. They typically contain a zinc-binding motif t...

[]

0

[ "PANTHER" ]

[ "PTHR21054" ]

[ "Metalloproteinase_M10B" ]

[ 3287 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 36, 3247, 4 ]

3

[ "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1 ]

4

true

Family

Zinc-dependent metalloproteinase M10B

Metalloproteinase_M10B

9

IPR053003

53,003

TRIM/RBCC E3 ubiquitin-protein ligases

TRIM_RBCC_E3_ubiq-ligases

Family

3,137

true

false

The TRIM/RBCC family includes E3 ubiquitin-protein ligases involved in various cellular processes. Members of this family play a crucial role in maintaining centrosome integrity by preventing centriole reduplication, likely through ubiquitination of proteins that promote this process. They also participate in epigeneti...

[]

0

[ "PANTHER" ]

[ "PTHR36754" ]

[ "TRIM_RBCC_E3_ubiq-ligases" ]

[ 3137 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

2

[ "3lrq" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3137 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 8 ]

4

true

Family

TRIM/RBCC E3 ubiquitin-protein ligases

TRIM_RBCC_E3_ubiq-ligases

4

IPR053004

53,004

MAGUK Family Regulators of Signaling Pathways

MAGUK_Signaling_Regulators

Family

3,028

true

false

The MAGUK family proteins are multifunctional regulators of various signaling pathways. They are pivotal in the Hippo signaling pathway, where they can both negatively and positively modulate the pathway's activity. They facilitate interactions between different kinases and other proteins to control kinase activity and...

[]

0

[ "PANTHER" ]

[ "PTHR46360" ]

[ "MAGUK_Signaling_Regulators" ]

[ 3028 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9013420", "R-HSA-9013424", "R-HSA-9696264", "R-HSA-9696270", "R-HSA-9696273", "R-MMU-9013420", "R-MMU-9013424", "R-MMU-9696264", "R-MMU-9696270", "R-MMU-9696273" ]

[ "REACTOME:R-HSA-9013420", "REACTOME:R-HSA-9013424", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-9013420", "REACTOME:R-MMU-9013424", "REACTOME:R-MMU-9696264", "REACTOME:R-MMU-9696270", "REACTOME:R-MMU-9696273" ]

10

[ "1uit" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3028 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 14, 3, 5, 10, 5 ]

6

true

Family

MAGUK Family Regulators of Signaling Pathways

MAGUK_Signaling_Regulators

5

IPR053005

53,005

Nuclear Positioning and Cytoskeleton Interaction Protein

Nuclear_Pos-Cytoskel_Interact

Family

3,039

true

false

This family of proteins is involved in the regulation of nuclear positioning and cytoskeletal interactions during cell division. Members of this family play a crucial role in the completion of asexual development by ensuring proper nuclear placement within the cell. They are also responsible for the formation of cortic...

[]

0

[ "PANTHER" ]

[ "PTHR28190" ]

[ "Nuclear_Pos-Cytoskel_Interact" ]

[ 3039 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3039 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1 ]

2

true

Family

Nuclear Positioning and Cytoskeleton Interaction Protein

Nuclear_Pos-Cytoskel_Interact

6

IPR053006

53,006

Meiosis-associated regulatory protein

Meiosis_regulatory

Family

2,938

true

false

This family of proteins is involved in the process of meiosis, which is a type of cell division that reduces the chromosome number by half and results in the production of gametes or spores. The known function within this family is associated with a regulatory role during the meiotic phase of the cell cycle. While one ...

[]

0

[ "PANTHER" ]

[ "PTHR28094" ]

[ "Meiosis_regulatory" ]

[ 2938 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "gut metagenome" ]

[ 2937, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Meiosis-associated regulatory protein

Meiosis_regulatory

5

IPR053007

53,007

Cytochrome P450 monooxygenase involved in secondary metabolism

CYP450_monoxygenase_sec-met

Family

3,232

true

false

This family of proteins includes cytochrome P450 monooxygenases involved in the biosynthesis of various secondary metabolites. These enzymes catalyze oxidation reactions that modify substrates by introducing oxygen atoms, often as part of larger biosynthetic pathways for complex organic compounds. They play crucial rol...

[]

0

[ "PANTHER" ]

[ "PTHR47582" ]

[ "CYP450_monoxygenase_sec-met" ]

[ 3232 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3232 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Cytochrome P450 monooxygenase involved in secondary metabolism

CYP450_monoxygenase_sec-met

1

IPR053008

53,008

Phomopsin biosynthesis-associated protein

Phomopsin_biosynth_assoc

Family

3,056

true

false

This family of proteins is involved in the biosynthesis of phomopsins, which are hexapeptide mycotoxins known to cause lupinosis in livestock. These proteins operate within a gene cluster, orchestrating a series of post-translational modifications (PTMs) to produce and modify the core hexapeptide derived from a precurs...

[]

0

[ "PANTHER" ]

[ "PTHR35896" ]

[ "Phomopsin_biosynth_assoc" ]

[ 3056 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3056 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Phomopsin biosynthesis-associated protein

Phomopsin_biosynth_assoc

6

IPR053010

53,010

SET domain-containing protein SmydA-8

SET_SmydA-8

Family

3,209

true

false

This family of proteins includes SET domain-containing proteins that are part of the class V-like SAM-binding methyltransferase superfamily. These proteins are characterized by the presence of a SET domain, which is associated with lysine methyltransferase activity. Typically, members of this family are involved in the...

[]

0

[ "PANTHER" ]

[ "PTHR46455" ]

[ "SET_SmydA-8" ]

[ 3209 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3209 ]

1

[ "Drosophila melanogaster" ]

[ 20 ]

1

true

Family

SET domain-containing protein SmydA-8

SET_SmydA-8

3

IPR053011

53,011

Dehydrogenase/reductase SDR family member 7

SDR_family_member_7

Family

2,218

true

false

The Dehydrogenase/reductase SDR family member 7 proteins are NADPH-dependent oxidoreductases involved in the reduction of compounds with carbonyl groups, including steroids, retinoids, and xenobiotics. They play a role in the inactivation of 5alpha-dihydrotestosterone, potentially affecting androgen receptor function, ...

[]

0

[ "PANTHER" ]

[ "PTHR44269" ]

[ "SDR_family_member_7" ]

[ 2218 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 189, 2025, 4 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 6, 8, 8 ]

5

true

Family

Dehydrogenase/reductase SDR family member 7

SDR_family_member_7

9

IPR053012

53,012

Endoplasmic reticulum-organelle contact domain-containing protein

ER-organelle_contact

Family

2,701

true

false

This family of proteins is involved in the establishment of contact sites between the endoplasmic reticulum (ER) and various organelles such as endosomes, mitochondria, and the Golgi apparatus. They interact with proteins that contain conventional and phosphorylated FFAT motifs, which are bound to these organelles, fac...

[]

0

[ "PANTHER" ]

[ "PTHR46384" ]

[ "ER-organelle_contact" ]

[ 2701 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-HSA-9013405", "R-MMU-6798695", "R-MMU-9013405" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9013405", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-9013405" ]

4

[ "1wic", "6tqs", "6tqt", "6tqu" ]

4

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2701 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 12, 3, 3, 7 ]

6

true

Family

Endoplasmic reticulum-organelle contact domain-containing protein

ER-organelle_contact

5

IPR053013

53,013

Lysine Acetyltransferase

LAT

Family

2,692

true

false

This family of proteins includes lysine acetyltransferases, which are enzymes that catalyze the transfer of an acetyl group from acetyl-CoA to the epsilon-amino group of a lysine residue on a substrate protein. This modification can affect the protein's function, interactions, stability, or localization. The acetylatio...

[]

0

[ "PANTHER" ]

[ "PTHR34815" ]

[ "LAT" ]

[ 2692 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 143, 2546, 3 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1 ]

2

true

Family

Lysine Acetyltransferase

LAT

3

IPR053014

53,014

Cuticle-associated divergent protein

Cuticle_assoc_divergent

Family

2,576

true

false

This family of proteins includes members with potential roles in cuticle biosynthesis, although their specific biochemical activities may vary. One member appears to lack serine protease inhibitor activity when tested in vitro, suggesting a divergence in function within the family. The proteins may have evolved distinc...

[]

0

[ "PANTHER" ]

[ "PTHR46339" ]

[ "Cuticle_assoc_divergent" ]

[ 2576 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 2576 ]

1

[ "Caenorhabditis elegans" ]

[ 31 ]

1

true

Family

Cuticle-associated divergent protein

Cuticle_assoc_divergent

2

IPR053015

53,015

Pleckstrin homology domain-containing protein M2

PH_domain-containing_M2

Family

2,524

true

false

This family of proteins is involved in intracellular vesicle trafficking, particularly affecting lysosome movement and localization. They act as effectors for small GTPase ARL8B, facilitating the recruitment of kinesin-1 to lysosomes, which in turn promotes their transport along microtubules. These proteins are also ke...

[]

0

[ "PANTHER" ]

[ "PTHR46556" ]

[ "PH_domain-containing_M2" ]

[ 2524 ]

1

[]

0

[ "3cxb", "3hw2", "8jca" ]

3

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2524 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 3, 9, 5, 5 ]

6

true

Family

Pleckstrin homology domain-containing protein M2

PH_domain-containing_M2

9

IPR053016

53,016

CTF18-RFC complex component

CTF18-RFC_complex

Family

3,568

true

false

This family of proteins includes components of the CTF18-RFC complex, which is involved in sister chromatid cohesion and the fidelity of chromosome transmission. These proteins function as chromosome cohesion factors and play a role in the cell nuclear antigen loader complexes. They are involved in the ATP-dependent lo...

[]

0

[ "PANTHER" ]

[ "PTHR46765" ]

[ "CTF18-RFC_complex" ]

[ 3568 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-174411", "R-HSA-174411", "R-MMU-174411" ]

[ "REACTOME:R-DME-174411", "REACTOME:R-HSA-174411", "REACTOME:R-MMU-174411" ]

3

[ "8umt", "8umu", "8umv", "8umw", "8umy", "8un0", "8unj", "8zwo", "9iin" ]

9

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3567, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 1, 2, 5, 4, 5, 3, 1, 15 ]

9

true

Family

CTF18-RFC complex component

CTF18-RFC_complex

1

IPR053017

53,017

Mitochondrial Citrate/Oxoglutarate Carrier

Mito_Cit/Oxoglu_Carrier

Family

2,507

true

false

This family of proteins includes mitochondrial antiporters that facilitate the transport of various dicarboxylic acids across the mitochondrial membrane. Members of this family are involved in the exchange of citrate and oxoglutarate, and can also transport other substrates such as oxaloacetate, succinate, fumarate, is...

[]

0

[ "PANTHER" ]

[ "PTHR46982" ]

[ "Mito_Cit/Oxoglu_Carrier" ]

[ 2507 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "seawater metagenome" ]

[ 2506, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

Mitochondrial Citrate/Oxoglutarate Carrier

Mito_Cit/Oxoglu_Carrier

6

IPR053018

53,018

Elsinochrome Biosynthesis-Associated

Elsinochrome_Biosynth-Asso

Family

2,602

true

false

This family of proteins is involved in the biosynthesis of elsinochromes, a group of pigments with a core phenolic quinone structure and various side chains. These pigments exist as interconvertible tautomers and are significant in fungal pathogenesis. The family includes enzymes that participate in the iterative decar...

[]

0

[ "PANTHER" ]

[ "PTHR37577" ]

[ "Elsinochrome_Biosynth-Asso" ]

[ 2602 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2602 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 5 ]

1

true

Family

Elsinochrome Biosynthesis-Associated

Elsinochrome_Biosynth-Asso

8

IPR053019

53,019

GATA zinc finger domain-containing protein

GATA_zinc_finger

Family

1,715

true

false

This family of proteins includes transcription factors that are involved in the regulation of morphogenetic cell movements during developmental processes. Members of this family are characterized by the presence of a GATA zinc finger domain, which is typically involved in DNA binding and the control of gene expression....

[]

0

[ "PANTHER" ]

[ "PTHR23353" ]

[ "GATA_zinc_finger" ]

[ 1715 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Naldaviricetes", "viral metagenome" ]

[ 39, 1649, 7, 18, 2 ]

5

[ "Drosophila melanogaster", "Homo sapiens", "Mus musculus" ]

[ 1, 2, 1 ]

3

true

Family

GATA zinc finger domain-containing protein

GATA_zinc_finger

5

IPR053020

53,020

Smr domain-containing protein

Smr_domain_protein

Family

2,439

true

false

This family of proteins includes members that contain an Smr domain, which is associated with DNA-binding and endonuclease activities. These proteins are involved in various DNA repair processes, including the repair of interstrand cross-links and the maintenance of genomic stability. The Smr domain facilitates the rec...

[]

0

[ "PANTHER" ]

[ "PTHR47417" ]

[ "Smr_domain_protein" ]

[ 2439 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 2435 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Smr domain-containing protein

Smr_domain_protein

2

IPR053021

53,021

Chloroplastic Adenylate Kinase

Chloroplast_ADK

Family

2,221

true

false

This family of proteins includes enzymes that are involved in the maintenance of cellular energy homeostasis and adenine nucleotide metabolism. Members of this family are capable of catalyzing the reversible transfer of a phosphate group between ATP and AMP. This reaction is a fundamental process in the energy exchange...

[]

0

[ "PANTHER" ]

[ "PTHR35509" ]

[ "Chloroplast_ADK" ]

[ 2221 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 361, 1860 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 5, 12 ]

3

true

Family

Chloroplastic Adenylate Kinase

Chloroplast_ADK

6

IPR053023

53,023

FLUCTUATING-LIGHT-ACCLIMATION modulator

FLAP_modulator

Family

2,179

true

false

This family of proteins is involved in the acclimation of photosynthetic organisms to fluctuating light conditions. Members of this family play a crucial role in maintaining intracellular pH homeostasis by modulating proton transport, which is essential for optimizing photosynthetic activity and balancing photoprotecti...

[]

0

[ "PANTHER" ]

[ "PTHR33975" ]

[ "FLAP_modulator" ]

[ 2179 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 536, 1643 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 11, 12 ]

3

true

Family

FLUCTUATING-LIGHT-ACCLIMATION modulator

FLAP_modulator

8

IPR053025

53,025

Mitochondrial ATP Synthase-Associated

Mito_ATP_Synthase-Asso

Family

2,055

true

false

This family of proteins is involved in mitochondrial function, specifically in the regulation of mitochondrial respiration. Members of this family are associated with the ATP synthase complex, aiding in ATP synthesis. They may also have a chaperone-like role in the maintenance of mitochondrial complex I, particularly t...

[]

0

[ "PANTHER" ]

[ "PTHR44873" ]

[ "Mito_ATP_Synthase-Asso" ]

[ 2055 ]

1

[]

0

[ "2yua" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Virus NIOZ-UU159", "metagenomes" ]

[ 44, 2005, 1, 5 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 1, 3, 6, 2 ]

5

true

Family

Mitochondrial ATP Synthase-Associated

Mito_ATP_Synthase-Asso

1

IPR053026

53,026

CDC42 guanine nucleotide exchange factor

CDC42_GEF

Family

2,470

true

false

This family of proteins includes guanine nucleotide exchange factors (GEFs) that are involved in the regulation of small GTPases, such as CDC42. Members of this family play a crucial role in cell signaling related to morphogenesis, mating, and cell division. They facilitate the exchange of GDP for GTP on CDC42, thereby...

[]

0

[ "PANTHER" ]

[ "PTHR47339" ]

[ "CDC42_GEF" ]

[ 2470 ]

1

[]

0

[ "1pqs", "1q1o", "1tz1", "2kfj", "2kfk" ]

5

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2470 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

CDC42 guanine nucleotide exchange factor

CDC42_GEF

6

IPR053027

53,027

Angiogenic factor with G patch and FHA domains 1

AGGF1

Family

2,354

true

false

The AGGF1 family is characterized by its role in promoting angiogenesis and endothelial cell proliferation. Members of the family have the ability to bind to endothelial cells, which may suggest an autocrine mechanism of action. The angiogenic factor with G patch and FHA domains, which defines this family, is involved ...

[]

0

[ "PANTHER" ]

[ "PTHR23106" ]

[ "AGGF1" ]

[ 2354 ]

1

[ "REACTOME" ]

[ "R-HSA-6802952" ]

[ "REACTOME:R-HSA-6802952" ]

1

[]

0

[]

0

[]

0

null

[ "Bacillati", "Eukaryota", "ecological metagenomes" ]

[ 17, 2334, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 6, 5, 2, 4 ]

6

true

Family

Angiogenic factor with G patch and FHA domains 1

AGGF1

5

IPR053028

53,028

Spo0E-like aspartyl-phosphate phosphatase

Spo0E-like_phosphatase

Family

1,665

true

false

This family of proteins includes aspartyl-phosphate phosphatases that are involved in the regulation of sporulation initiation. Members of this family are responsible for dephosphorylating the sporulation transcription factor Spo0A-P, which is a key step in the control of the timing of sporulation. By dephosphorylating...

[]

0

[ "PANTHER" ]

[ "PTHR41263" ]

[ "Spo0E-like_phosphatase" ]

[ 1665 ]

1

[]

0

[ "2bzb", "2c0s" ]

2

[]

0

[]

0

null

[ "Bacteria", "Geobacillus phage TP-84" ]

[ 1664, 1 ]

2

[]

0

true

Family

Spo0E-like aspartyl-phosphate phosphatase

Spo0E-like_phosphatase

9

IPR053029

53,029

Transcription initiation factor Rrn11

Rrn11

Family

2,236

false

The RNA polymerase I specific transcription initiation factor Rrn11 is a member of a multiprotein complex essential for the initiation of transcription by RNA polymerase I, together with Rrn6 and Rrn7 subunits [ , ]. Binding to the DNA template is dependent on the initial binding of other factors [ ]. Rrn11 contains a ...

[]

0

[ "PANTHER" ]

[ "PTHR28244" ]

[ "" ]

[ 2236 ]

1

[]

0

[ "5n5y", "5n5z", "5n60", "5n61", "5o7x", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6rqh", "6rql", "6rrd", "6rui", "6ruo", "6rwe", "6tps" ]

17

[ "PUB00020262", "PUB00099775", "PUB00100002" ]

[ "12095692", "28340337", "28623663" ]

[ "Characterization of a fission yeast subunit of an RNA polymerase I essential transcription initiation factor, SpRrn7h/TAF(I)68, that bridges yeast and mammals: association with SpRrn11h and the core ribosomal RNA gene promoter.", "Structural Basis of RNA Polymerase I Transcription Initiation.", "Structural mec...

[ 2002, 2017, 2017 ]

3

[]

[ "IPR016850" ]

0

1

0

[ "Eukaryota" ]

[ 2236 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

Transcription initiation factor Rrn11

Rrn11

8

IPR053030

53,030

Ribosomal biogenesis protein FAF1-like

Ribosomal_biogenesis_FAF1-like

Family

2,413

true

false

This family of proteins is involved in the maturation of ribosomes, which are essential cellular machines for protein synthesis. Members of this family are implicated in the processing of precursor ribosomal RNA (rRNA), specifically contributing to the cleavage events that are necessary for the proper formation of the ...

[]

0

[ "PANTHER" ]

[ "PTHR28096" ]

[ "Ribosomal_biogenesis_FAF1-like" ]

[ 2413 ]

1

[]

0

[ "5oql", "5wlc", "6ke6", "6lqp", "6lqq", "6lqu", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "7ajt", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z" ]

23

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2413 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 2, 1, 1, 20 ]

6

true

Family

Ribosomal biogenesis protein FAF1-like

Ribosomal_biogenesis_FAF1-like

6

IPR053031

53,031

Cuticle-associated protein

Cuticle_assoc_protein

Family

3,265

true

false

This family of proteins is associated with cuticle structure and integrity. Members of this family are implicated in the proper formation and function of the cuticle, which is an external layer found in some organisms that serves as a protective barrier. These proteins may play a role either directly in the composition...

[]

0

[ "PANTHER" ]

[ "PTHR34396" ]

[ "Cuticle_assoc_protein" ]

[ 3265 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3265 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 1, 27, 15 ]

4

true

Family

Cuticle-associated protein

Cuticle_assoc_protein

6

IPR053032

53,032

Bromo adjacent homology domain-containing protein

BAH_domain-containing

Family

2,124

true

false

This family of proteins functions as transcription repressors involved in the formation and maintenance of heterochromatin. Members of this family have the ability to recruit various heterochromatin proteins, including CBX5 (HP1 alpha), HDAC5, and MBD1, to specific genomic regions. They are known to repress the express...

[]

0

[ "PANTHER" ]

[ "PTHR46576" ]

[ "BAH_domain-containing" ]

[ 2124 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2124 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 5, 7, 1, 3, 1, 3 ]

6

true

Family

Bromo adjacent homology domain-containing protein

BAH_domain-containing

5

IPR053033

53,033

Androglobin-like

Family

2,062

true

false

This family of proteins is implicated in the reproductive process, specifically in the development and maturation of male gametes. Members are essential for the formation of the sperm flagellum and the maturation of elongating spermatids, which are critical for male fertility. Additionally, these proteins are involved ...

[]

0

[ "PANTHER" ]

[ "PTHR46298" ]

[ "Androglobin-like" ]

[ 2062 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2062 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 12, 4, 6 ]

4

true

Family

Androglobin-like

2

IPR053034

53,034

Glucuronokinase-like

Family

1,517

true

false

This family of proteins includes enzymes with sugar-1-kinase activity, specifically recognizing D-glucuronic acid and ATP as substrates. Members of this family are involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), which is a precursor for nucleotide sugars required in the assembly of cell-wall polymers. A...

[]

0

[ "PANTHER" ]

[ "PTHR38710" ]

[ "Glucuronokinase-like" ]

[ 1517 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "ecological metagenomes" ]

[ 144, 1, 1358, 14 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 3, 8 ]

4

true

Family

Glucuronokinase-like

1

IPR053035

53,035

Mitochondrial GEF domain-containing protein

Mitochondrial_GEF_domain

Family

2,100

true

false

This family of proteins functions as guanine nucleotide exchange factors (GEFs) for mitochondrial dynamin-related GTPases, specifically OPA1. They facilitate the activation of OPA1 by promoting the exchange of GDP for GTP, which is crucial for mitochondrial fusion processes, particularly those involving OPA1 and MFN1. ...

[]

0

[ "PANTHER" ]

[ "PTHR46337" ]

[ "Mitochondrial_GEF_domain" ]

[ 2100 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6793080", "R-HSA-9937008" ]

[ "REACTOME:R-HSA-6793080", "REACTOME:R-HSA-9937008" ]

2

[ "5xgs" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 3, 2096, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 3, 3, 2, 3 ]

6

true

Family

Mitochondrial GEF domain-containing protein

Mitochondrial_GEF_domain

4

IPR053036

53,036

Cell Cycle and DNA Repair Regulator

CellCycle_DNARepair_Reg

Family

2,221

true

false

The protein family in question is involved in maintaining genomic stability and proper cell cycle progression. Members of this family are essential for ensuring mitotic fidelity, particularly during the G2 phase, and play a role in chromatin organization. Additionally, they are implicated in the resumption of chromosom...

[]

0

[ "PANTHER" ]

[ "PTHR47667" ]

[ "CellCycle_DNARepair_Reg" ]

[ 2221 ]

1

[]

0

[ "3l40", "3l41", "3t7i", "3t7j", "3t7k", "6j0v", "6j0w", "6j0x", "6j0y" ]

9

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2221 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cell Cycle and DNA Repair Regulator

CellCycle_DNARepair_Reg

2

IPR053037

53,037

Pericyclase pydY-like

Pericyclase_pydY-like

Family

2,125

true

false

This family of proteins includes enzymes that are involved in the biosynthesis of complex natural products with antibiotic properties. Members of this family function as pericyclases, which catalyze key steps in the formation of macrocyclic and polycyclic compounds. Specifically, they are implicated in a Diels-Alder cy...

[]

0

[ "PANTHER" ]

[ "PTHR38115" ]

[ "Pericyclase_pydY-like" ]

[ 2125 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 2125 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Pericyclase pydY-like

Pericyclase_pydY-like

1

IPR053040

53,040

Leucine-rich repeat-containing protein 71

LRR-containing_protein_71

Family

2,028

true

false

This family of proteins contains leucine-rich repeat (LRR) domains, which typically mediate protein-protein interactions and are involved in various cellular processes including signal transduction, cell adhesion, DNA repair, and immune responses. Members of this family are likely to play a role in these biological fun...

[]

0

[ "PANTHER" ]

[ "PTHR46984" ]

[ "LRR-containing_protein_71" ]

[ 2028 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadota", "marine metagenome" ]

[ 2025, 2, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 3, 2, 3 ]

4

true

Family

Leucine-rich repeat-containing protein 71

LRR-containing_protein_71

6

IPR053041

53,041

Transglutaminase-like Superfamily Modulators

Transglut-like_Superfamily_Mod

Family

2,092

true

false

The Transglutaminase-like Superfamily Protein Family is characterized by proteins that share structural similarity and are involved in various cellular processes. Members of this family, such as Hillarin and LTD-1, are implicated in the modulation of cytoskeletal elements and cellular division. Hillarin is suggested to...

[]

0

[ "PANTHER" ]

[ "PTHR47020" ]

[ "Transglut-like_Superfamily_Mod" ]

[ 2092 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 2090 ]

2

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 1, 1 ]

2

true

Family

Transglutaminase-like Superfamily Modulators

Transglut-like_Superfamily_Mod

7

IPR053042

53,042

Mitochondrial GTP/GDP Carrier

Mito_GTP/GDP_Carrier

Family

2,016

true

false

This family of proteins includes mitochondrial carriers that facilitate the transport of nucleotides across the inner mitochondrial membrane. Specifically, they are involved in the exchange of GTP and GDP, which is crucial for various mitochondrial functions including iron transport and the maintenance of mitochondrial...

[]

0

[ "PANTHER" ]

[ "PTHR46974" ]

[ "Mito_GTP/GDP_Carrier" ]

[ 2016 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Gammaproteobacteria", "marine metagenome" ]

[ 2012, 3, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial GTP/GDP Carrier

Mito_GTP/GDP_Carrier

3

IPR053043

53,043

Ras-cAMP pathway regulatory protein

Ras-cAMP_regulatory

Family

2,021

true

false

This family of proteins includes members that are involved in the negative regulation of the Ras-cAMP signaling pathway. They play a role in the transcriptional regulation of genes that are inducible by galactose. The family features proteins that may have a regulatory function in signal transduction processes and coul...

[]

0

[ "PANTHER" ]

[ "PTHR28014" ]

[ "Ras-cAMP_regulatory" ]

[ 2021 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2021 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Ras-cAMP pathway regulatory protein

Ras-cAMP_regulatory

9

IPR053044

53,044

Metallo-dependent Hydrolase/TatD-type

Metallo-hydrolase/TatD-type

Family

1,920

true

false

This family of proteins includes members that are involved in interactions with other proteins, such as the Cut9 protein, suggesting a role in cellular processes that require protein-protein interactions. Additionally, the family is characterized by a similarity to metallo-dependent hydrolases, indicating that members ...

[]

0

[ "PANTHER" ]

[ "PTHR47345" ]

[ "Metallo-hydrolase/TatD-type" ]

[ 1920 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1920 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Metallo-dependent Hydrolase/TatD-type

Metallo-hydrolase/TatD-type

5

IPR053045

53,045

Zinc cluster transcription regulator

Zinc_cluster_trans_reg

Family

1,900

true

false

This family of proteins includes zinc cluster transcription factors that are involved in the regulation of various metabolic processes. Members of this family are known to govern gene expression related to iron acquisition, both through reductive and siderophore-mediated pathways, which are crucial for organismal virul...

[]

0

[ "PANTHER" ]

[ "PTHR31986" ]

[ "Zinc_cluster_trans_reg" ]

[ 1900 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1900 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Zinc cluster transcription regulator

Zinc_cluster_trans_reg

6

IPR053046

53,046

ABC-5 integral membrane transporter

ABC-5_transporter

Family

1,298

true

false

This family of proteins is involved in the transport of specific substrates across cellular membranes. Members of this family are integral components of ABC transporter complexes, which are typically involved in the import or export of various molecules in response to cellular needs. Specifically, these proteins have b...

[]

0

[ "PANTHER" ]

[ "PTHR39177" ]

[ "ABC-5_transporter" ]

[ 1298 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1298 ]

1

[]

0

true

Family

ABC-5 integral membrane transporter

ABC-5_transporter

3

IPR053047

53,047

E3 ubiquitin ligase TRAF3IP2

E3_ubiq_ligase_TRAF3IP2

Family

1,566

true

false

This family of proteins includes E3 ubiquitin ligases that are involved in 'Lys-63'-linked polyubiquitination, a post-translational modification that enhances protein-protein interactions and cell signaling. Members of this family function as adapter molecules in IL17A-mediated signaling pathways. They are capable of i...

[]

0

[ "PANTHER" ]

[ "PTHR34257" ]

[ "E3_ubiq_ligase_TRAF3IP2" ]

[ 1566 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Bilateria", "Methanosarcina mazei" ]

[ 13, 1548, 5 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 5, 6, 5 ]

4

true

Family

E3 ubiquitin ligase TRAF3IP2

E3_ubiq_ligase_TRAF3IP2

3

IPR053049

53,049

TSC22 domain-containing protein 2

TSC22_domain_protein_2

Family

1,770

true

false

This family of proteins is involved in the regulation of cell growth through the modulation of specific isoforms of nuclear enzymes and transcription factors. Members of this family can reduce the levels of the nuclear PKM isoform M2, leading to the repression of cyclin CCND1 transcription. This action is associated wi...

[]

0

[ "PANTHER" ]

[ "PTHR46894" ]

[ "TSC22_domain_protein_2" ]

[ 1770 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 1770 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 5, 3 ]

4

true

Family

TSC22 domain-containing protein 2

TSC22_domain_protein_2

6

IPR053052

53,052

Imprinting Balance Regulator

Imprinting_Balance_Reg

Family

2,289

true

false

This family of proteins includes members involved in the regulation of gene expression through imprinting mechanisms. They play a crucial role in maintaining the balance of parental gene contributions, particularly in the endosperm, which is essential for proper seed development. These proteins are also implicated in p...

[]

0

[ "PANTHER" ]

[ "PTHR45496" ]

[ "Imprinting_Balance_Reg" ]

[ 2289 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Magnoliopsida" ]

[ 2289 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 14, 19 ]

3

true

Family

Imprinting Balance Regulator

Imprinting_Balance_Reg

3

IPR053053

53,053

WD repeat-containing protein

WD_repeat_protein

Family

1,935

true

false

This family of proteins contains WD repeat domains, which are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his (GH) and tryptophan-aspartic acid (WD) dipeptides. Proteins with WD repeats are involved in a variety of cellular processes, including signal transduction, RNA process...

[]

0

[ "PANTHER" ]

[ "PTHR44566" ]

[ "WD_repeat_protein" ]

[ 1935 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Flammeovirga aprica JL-4" ]

[ 1934, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 3, 5, 1, 2, 4, 4 ]

7

true

Family

WD repeat-containing protein

WD_repeat_protein

9

IPR053054

53,054

DNA repair-scaffolding protein

DNA_repair-scaffolding

Family

1,725

true

false

This family of proteins is involved in the cellular response to DNA damage, specifically in the repair of double-strand breaks (DSBs) through the homologous recombination (HR) pathway. Members of this family function as scaffolding proteins, facilitating the assembly of DNA repair complexes at sites of damage. They are...

[]

0

[ "PANTHER" ]

[ "PTHR34347" ]

[ "DNA_repair-scaffolding" ]

[ 1725 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5693568", "R-MMU-5693568" ]

[ "REACTOME:R-HSA-5693568", "REACTOME:R-MMU-5693568" ]

2

[]

0

[]

0

[]

0

null

[ "Metazoa" ]

[ 1725 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 16, 2, 5 ]

4

true

Family

DNA repair-scaffolding protein

DNA_repair-scaffolding

8

IPR053055

53,055

Vacuolar Protein Sorting-Associated 17

VPS17

Family

1,728

true

false

This family of proteins is involved in the endosomal sorting and trafficking pathway. Members play a crucial role in the retrograde transport from endosomes to the Golgi apparatus. They are components of the retromer complex, which is essential for the retrieval of specific cargo proteins, including the vacuolar protei...

[]

0

[ "PANTHER" ]

[ "PTHR47433" ]

[ "VPS17" ]

[ 1728 ]

1

[]

0

[ "7x4o" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1728 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Vacuolar Protein Sorting-Associated 17

VPS17

9

IPR053056

53,056

Lipid Metabolism-Associated Protein

Lipid_Metab_Assoc_Protein

Family

1,695

true

false

This family of proteins may be associated with cellular lipid metabolic processes. The precise functions of these proteins remain to be fully characterized, but they are hypothesized to play a role in the metabolism of lipids, which are crucial components of cell membranes and serve as energy storage molecules. Further...

[]

0

[ "PANTHER" ]

[ "PTHR28153" ]

[ "Lipid_Metab_Assoc_Protein" ]

[ 1695 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1695 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Lipid Metabolism-Associated Protein

Lipid_Metab_Assoc_Protein

6

IPR053057

53,057

Extra-large GTP-binding protein

XLG_GTP-binding

Family

1,809

true

false

This family of proteins includes guanine nucleotide-binding proteins that act as modulators or transducers in various transmembrane signaling systems. They specifically bind GTP and are implicated in the regulation of cell proliferation during root morphogenesis. Additionally, members of this family serve as positive r...

[]

0

[ "PANTHER" ]

[ "PTHR36486" ]

[ "XLG_GTP-binding" ]

[ 1809 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Streptophytina" ]

[ 1809 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 4, 8 ]

3

true

Family

Extra-large GTP-binding protein

XLG_GTP-binding

4

IPR053058

53,058

Mulikevirus tape measure

Mulikevirus_tape_measure

Family

1,260

true

false

The Mulikevirus tape measure protein family is involved in the assembly and length determination of bacteriophage tails. Members of this family serve as a scaffold for the polymerization of tail tube proteins, ensuring the correct tail length is achieved. These proteins may also be involved in the ejection process of t...

[]

0

[ "PANTHER" ]

[ "PTHR38812" ]

[ "Mulikevirus_tape_measure" ]

[ 1260 ]

1

[]

0

[ "9ki1" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1003, 5, 231, 21 ]

4

[]

0

true

Family

Mulikevirus tape measure

Mulikevirus_tape_measure

6

IPR053060

53,060

Cytokinesis Signaling Regulator

Cytokinesis_Signaling_Reg

Family

1,583

true

false

This family of proteins is involved in cytokinesis, the process of cell division that results in the separation of a cell into two daughter cells. Members of this family play roles in signaling pathways that regulate cell wall synthesis and actin assembly during this critical phase of the cell cycle. Some proteins in t...

[]

0

[ "PANTHER" ]

[ "PTHR36419" ]

[ "Cytokinesis_Signaling_Reg" ]

[ 1583 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1583 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cytokinesis Signaling Regulator

Cytokinesis_Signaling_Reg

6

IPR053061

53,061

AN1-type zinc finger domain-containing protein

AN1-type_zinc_finger

Family

1,599

true

false

This family of proteins includes members that contain AN1-type zinc finger domains. These domains are typically involved in protein-protein interactions and may bind zinc ions to stabilize their structure. Proteins in this family are likely to be involved in various cellular processes, including signal transduction, DN...

[]

0

[ "PANTHER" ]

[ "PTHR46728" ]

[ "AN1-type_zinc_finger" ]

[ 1599 ]

1

[]

0

[ "1wff" ]

1

[]

0

[]

0

null

[ "Eukaryota", "Yasminevirus sp. GU-2018", "viral metagenome" ]

[ 1596, 1, 2 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 10, 6, 9 ]

4

true

Family

AN1-type zinc finger domain-containing protein

AN1-type_zinc_finger

3

IPR053062

53,062

Cytochrome P450 84A

CYP450_84A

Family

1,807

true

false

This family of proteins includes enzymes that are part of the cytochrome P450 superfamily, known for their role in the oxidative metabolism of a wide range of substrates. Members of this family are involved in various biosynthetic processes, including the conversion of p-coumaraldehyde to caffealdehyde, which is a step...

[]

0

[ "PANTHER" ]

[ "PTHR47945" ]

[ "CYP450_84A" ]

[ 1807 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spermatophyta" ]

[ 1807 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 13, 15 ]

3

true

Family

Cytochrome P450 84A

CYP450_84A

2

IPR053063

53,063

PWWP domain-containing

PWWP_domain_containing_PDP

Family

2,082

true

false

The PDP family is involved in the regulation of flowering in Arabidopsis thaliana. Members of the PDP family, such as PDP2 and PDP5, interact with components of the Polycomb Repressive Complex 2 (PRC2) and influence gene expression by modulating the levels of the histone modification H3K27me3. Through this interaction,...

[]

0

[ "PANTHER" ]

[ "PTHR42851" ]

[ "PWWP_domain_containing_PDP" ]

[ 2082 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2082 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 15, 43 ]

3

true

Family

PWWP domain-containing

PWWP_domain_containing_PDP

6

IPR053065

53,065

Archenteron Induction-Related

Archenteron_Induction-Rel

Family

1,489

true

false

This family of proteins includes factors that may play a role in early developmental processes such as gastrulation. Specifically, members of this family have been implicated in influencing the movement of the archenteron, a structure involved in the development of the gut in embryos. The exact mechanisms and the bread...

[]

0

[ "PANTHER" ]

[ "PTHR36853" ]

[ "Archenteron_Induction-Rel" ]

[ 1489 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1489 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Archenteron Induction-Related

Archenteron_Induction-Rel

5

IPR053066

53,066

Adhesion G-protein coupled receptor G7

ADGR_G7

Family

2,094

true

false

This family of proteins includes orphan receptors that are part of the G-protein coupled receptor 2 family, specifically within the Adhesion G-protein coupled receptor (ADGR) subfamily. These receptors are characterized by their seven transmembrane domains, typical of G-protein coupled receptors, and are involved in ce...

[]

0

[ "PANTHER" ]

[ "PTHR47767" ]

[ "ADGR_G7" ]

[ 2094 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2094 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 6, 1, 2 ]

5

true

Family

Adhesion G-protein coupled receptor G7

ADGR_G7

5

IPR053069

53,069

TVP38/Transmembrane protein 64

TVP38/TMEM64

Family

1,372

true

false

The TVP38/TMEM64 family is involved in the regulation of cell differentiation processes, particularly affecting osteoclast and adipocyte lineage commitment. Family members positively regulate osteoclast differentiation by enhancing TNFSF11-induced calcium signaling pathways, which involve interaction with SERCA2. This ...

[]

0

[ "PANTHER" ]

[ "PTHR46593" ]

[ "TVP38/TMEM64" ]

[ 1372 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1372 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 4, 1, 7 ]

5

true

Family

TVP38/Transmembrane protein 64

TVP38/TMEM64

2

IPR053070

53,070

RING-type zinc finger E3 ubiquitin-protein ligase

RING-type_E3_ubiquitin-ligase

Family

1,658

true

false

This family of proteins includes E3 ubiquitin-protein ligases that are capable of catalyzing the polyubiquitination process. They interact with various ubiquitin-conjugating enzymes (E2s) such as UBC8, UBC10, UBC11, and UBC34 in vitro. The presence of a RING-type zinc finger domain is characteristic of these proteins, ...

[]

0

[ "PANTHER" ]

[ "PTHR47035" ]

[ "RING-type_E3_ubiquitin-ligase" ]

[ 1658 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Imitervirales", "metagenomes" ]

[ 1642, 2, 14 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 14, 14 ]

3

true

Family

RING-type zinc finger E3 ubiquitin-protein ligase

RING-type_E3_ubiquitin-ligase

9

IPR053071

53,071

GPCR1-related receptor

GPCR1-related_rcpt

Family

1,349

true

false

This family of proteins includes G-protein coupled receptors that interact with diverse ligands to mediate various physiological responses. Members are involved in controlling reproductive behaviors and sleep homeostasis in Drosophila, as well as aversive gustatory associative learning and long-term memory formation in...

[]

0

[ "PANTHER" ]

[ "PTHR47023" ]

[ "GPCR1-related_rcpt" ]

[ 1349 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Protostomia" ]

[ 1349 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 5, 7 ]

2

true

Family

GPCR1-related receptor

GPCR1-related_rcpt

3

IPR053072

53,072

BEN domain-containing protein 7

BEN_domain_protein_7

Family

1,262

true

false

This family of proteins includes members that contain a BEN domain, which is known to mediate protein-DNA and protein-protein interactions. These interactions are often involved in chromatin organization and gene expression regulation. Proteins with a BEN domain may play roles in various cellular processes, including c...

[]

0

[ "PANTHER" ]

[ "PTHR35068" ]

[ "BEN_domain_protein_7" ]

[ 1262 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Deuterostomia" ]

[ 1262 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 9, 4, 5 ]

4

true

Family

BEN domain-containing protein 7

BEN_domain_protein_7

6

IPR053073

53,073

Interleukin-11/Interleukin-27 subunit beta

IL11/IL27_subunit_beta

Family

2,148

false

Interleukin-27 subunit beta is involved in the formation of IL-27, a heterodimeric cytokine playing a role in innate immunity. IL-27 has both pro- and anti-inflammatory properties, influencing T-helper cell development, suppressing T-cell proliferation, and stimulating cytotoxic T-cell activity. It is pivotal for the d...

[]

0

[ "PANTHER" ]

[ "PTHR48483" ]

[ "" ]

[ 2148 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6788467", "R-HSA-8984722", "R-HSA-9020956", "R-MMU-6788467", "R-MMU-8984722", "R-MMU-9020956", "R-RNO-6788467" ]

[ "REACTOME:R-HSA-6788467", "REACTOME:R-HSA-8984722", "REACTOME:R-HSA-9020956", "REACTOME:R-MMU-6788467", "REACTOME:R-MMU-8984722", "REACTOME:R-MMU-9020956", "REACTOME:R-RNO-6788467" ]

7

[ "6o4p", "7u7n", "7zg0", "7zxk", "8d85", "8dps", "8dpt", "8dpu", "8qy4", "8xwy" ]

10

[ "PUB00013131", "PUB00046036", "PUB00046037", "PUB00046038", "PUB00060212" ]

[ "9416001", "15992047", "15720388", "16003467", "12121660" ]

[ "Interleukin-11.", "The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease.", "Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss.", "Multiple and highly divergent IL-11 genes in teleost fish.", "IL-27, a heterodimeric cytoki...

[ 1997, 1998, 2005, 2005, 2002 ]

5

[]

0

null

[ "Geobacter hydrogenophilus", "Metazoa" ]

[ 1, 2147 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 8, 6, 4 ]

4

true

Family

Interleukin-11/Interleukin-27 subunit beta

IL11/IL27_subunit_beta

8

IPR053074

53,074

Nuclear Pore Complex Nucleoporin

NPC_Nucleoporin

Family

1,685

true

false

This family of proteins includes components of the nuclear pore complex (NPC), which is essential for the transport of molecules between the nucleus and the cytoplasm. Members of this family, known as nucleoporins (NUPs), serve dual functions as structural elements of the NPC and as interaction partners for nuclear tra...

[]

0

[ "PANTHER" ]

[ "PTHR38697" ]

[ "NPC_Nucleoporin" ]

[ 1685 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-SCE-159236", "R-SCE-170822", "R-SCE-3371453", "R-SCE-4085377", "R-SCE-4551638", "R-SCE-4570464", ...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-S...

26

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1685 ]

1

[ "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1 ]

4

true

Family

Nuclear Pore Complex Nucleoporin

NPC_Nucleoporin

9

IPR053075

53,075

Tumor necrosis factor receptor superfamily member 11A

TNFRSF11A

Family

1,193

true

false

This family of proteins includes receptors that are crucial for the process of osteoclastogenesis, which is the formation of osteoclasts. These receptors bind to the ligand TNFSF11/RANKL/TRANCE/OPGL and are essential for the signaling that leads to the differentiation and activation of osteoclasts. They are also involv...

[]

0

[ "PANTHER" ]

[ "PTHR47134" ]

[ "TNFRSF11A" ]

[ 1193 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5668541", "R-HSA-5676594", "R-MMU-5668541", "R-MMU-5676594" ]

[ "REACTOME:R-HSA-5668541", "REACTOME:R-HSA-5676594", "REACTOME:R-MMU-5668541", "REACTOME:R-MMU-5676594" ]

4

[ "3me2", "3me4", "3qbq", "4giq", "5bnq" ]

5

[]

0

[]

0

null

[ "Bilateria" ]

[ 1193 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 1, 1, 2 ]

4

true

Family

Tumor necrosis factor receptor superfamily member 11A

TNFRSF11A

1

IPR053076

53,076

WW domain-containing protein

WW_domain_protein

Family

1,288

true

false

This family of proteins includes members that contain WW domains, which are known to mediate protein-protein interactions. The WW domains in these proteins specifically recognize and bind to proline-rich motifs that are flanked by arginine and glycine residues in their target proteins. The presence of multiple WW domai...

[]

0

[ "PANTHER" ]

[ "PTHR46697" ]

[ "WW_domain_protein" ]

[ 1288 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1288 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 4, 3 ]

4

true

Family

WW domain-containing protein

WW_domain_protein

5

IPR053077

53,077

MARVEL domain-containing protein 3

MARVEL_domain_protein_3

Family

950

true

false

This family of proteins includes members that are integral components of tight junctions, which are structures that seal the space between adjacent epithelial cells. They are implicated in the regulation of paracellular ion transport across epithelial cell layers. The proteins in this family contain a MARVEL domain, wh...

[]

0

[ "PANTHER" ]

[ "PTHR34609" ]

[ "MARVEL_domain_protein_3" ]

[ 950 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 950 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 2 ]

5

true

Family

MARVEL domain-containing protein 3

MARVEL_domain_protein_3

5

IPR053078

53,078

Transcription Termination Factor 1-like

TTF1-like

Family

1,160

true

false

This family of proteins includes multifunctional nucleolar components involved in the regulation of ribosomal gene transcription. They play a key role in both the activation and silencing of rDNA transcription. These proteins are responsible for terminating ribosomal gene transcription and mediating replication fork ar...

[]

0

[ "PANTHER" ]

[ "PTHR46760" ]

[ "TTF1-like" ]

[ 1160 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427389", "R-HSA-427413", "R-HSA-5683826", "R-HSA-73762", "R-HSA-73863", "R-MMU-5683826", "R-MMU-73762", "R-MMU-73863" ]

[ "REACTOME:R-HSA-427389", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73863", "REACTOME:R-MMU-5683826", "REACTOME:R-MMU-73762", "REACTOME:R-MMU-73863" ]

8

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1160 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 3, 2, 4 ]

4

true

Family

Transcription Termination Factor 1-like

TTF1-like

5

IPR053079

53,079

SPS2 domain-containing protein

SPS2_domain

Family

969

true

false

This family of proteins is involved in the structural development of cell walls in fungi, playing a crucial role in the formation of conidial and mycelial structures. Members of this family are implicated in the biogenesis of the cell wall, which is essential for cell shape, integrity, and response to environmental str...

[]

0

[ "PANTHER" ]

[ "PTHR21662" ]

[ "SPS2_domain" ]

[ 969 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Aquimarina aggregata", "Opisthokonta" ]

[ 1, 968 ]

2

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 60, 2 ]

2

true

Family

SPS2 domain-containing protein

SPS2_domain

6

IPR053080

53,080

Protein phosphatase 1 regulatory subunit 27

PP1_regulatory_subunit_27

Family

1,290

true

false

The Protein phosphatase 1 regulatory subunit 27 family consists of proteins that play a crucial role in the regulation of cellular processes by inhibiting the activity of protein phosphatase 1 (PP1) complexes. PP1 is a major serine/threonine phosphatase that is involved in the dephosphorylation of a variety of proteins...

[]

0

[ "PANTHER" ]

[ "PTHR46899" ]

[ "PP1_regulatory_subunit_27" ]

[ 1290 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Cowpox virus", "Eukaryota", "ecological metagenomes" ]

[ 47, 1, 1239, 3 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 2, 1, 1, 2, 3 ]

6

true

Family

Protein phosphatase 1 regulatory subunit 27

PP1_regulatory_subunit_27

5

IPR053081

53,081

Small Integral Membrane Modulators

SIM_Modulators

Family

1,017

true

false

This family of proteins includes small integral membrane components that are implicated in the modulation of lipid droplet formation. They may exert their function through interactions with enzymes involved in lipid metabolism, such as squalene epoxidase.

[]

0

[ "PANTHER" ]

[ "PTHR36982" ]

[ "SIM_Modulators" ]

[ 1017 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 1017 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 3 ]

4

true

Family

Small Integral Membrane Modulators

SIM_Modulators

1

IPR053082

53,082

Nuclear GTPase SLIP-GC

Nuclear_GTPase_SLIP-GC

Family

1,201

true

false

This family of proteins includes nuclear GTPases that are predominantly expressed in germinal center B-cells. Members of this family are implicated in the regulation of somatic hypermutation, a process critical for the diversification of the B-cell receptor repertoire. They exert their function by potentially inhibitin...

[]

0

[ "PANTHER" ]

[ "PTHR47308" ]

[ "Nuclear_GTPase_SLIP-GC" ]

[ 1201 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1201 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 25, 2, 2, 2 ]

4

true

Family

Nuclear GTPase SLIP-GC

Nuclear_GTPase_SLIP-GC

9

IPR053083

53,083

Transcription factor and kinase domain-containing protein

TF_kinase-domain_protein

Family

2,127

true

false

This family of proteins includes transcription factors involved in gene clusters that mediate biosynthesis of specific meroterpenoids with inhibitory effects on human receptors, as well as members that contain protein kinase domains. Some of these kinase domains may be catalytically inactive, yet they still belong to t...

[]

0

[ "PANTHER" ]

[ "PTHR44305" ]

[ "TF_kinase-domain_protein" ]

[ 2127 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 30, 2094, 3 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 4 ]

1

true

Family

Transcription factor and kinase domain-containing protein

TF_kinase-domain_protein

9

IPR053084

53,084

A-kinase anchor protein

AKAP

Family

1,044

true

false

This family of proteins is involved in the cellular anchoring of protein kinase A (PKA) regulatory subunits. Members of this family interact with the type II regulatory subunits of PKA, a pivotal enzyme in the cAMP signaling pathway, and play a crucial role in localizing the kinase to specific subcellular compartments....

[]

0

[ "PANTHER" ]

[ "PTHR35075" ]

[ "AKAP" ]

[ 1044 ]

1

[]

0

[ "9d2f", "9fqr" ]

2

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1044 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 3 ]

5

true

Family

A-kinase anchor protein

AKAP

9

IPR053085

53,085

Jasmonate-induced protein

Jasmonate-induced_protein

Family

1,368

true

false

This family of proteins is involved in the response to the plant hormone jasmonate. Jasmonates are lipid-based compounds that regulate various aspects of plant growth, development, and defense. Proteins in this family are typically induced by jasmonate signaling and may participate in diverse biological processes, incl...

[]

0

[ "PANTHER" ]

[ "PTHR36482" ]

[ "Jasmonate-induced_protein" ]

[ 1368 ]

1

[]

0

[ "5h0q" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 11, 1357 ]

2

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 13 ]

2

true

Family

Jasmonate-induced protein

Jasmonate-induced_protein

7

IPR053086

53,086

RhoGEF domain-containing protein

RhoGEF_domain

Family

972

true

false

This family of proteins includes members with a RhoGEF domain, which suggests a role in regulating GTPase activity. The proteins are involved in the activation of GTPases, a critical process for various cellular functions including signal transduction and cytoskeletal organization. Some members of this family may conta...

[]

0

[ "PANTHER" ]

[ "PTHR45834" ]

[ "RhoGEF_domain" ]

[ 972 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-193648", "R-DDI-9013148", "R-DDI-9013149", "R-DDI-9013406" ]

[ "REACTOME:R-DDI-193648", "REACTOME:R-DDI-9013148", "REACTOME:R-DDI-9013149", "REACTOME:R-DDI-9013406" ]

4

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 968 ]

2

[ "Drosophila melanogaster" ]

[ 14 ]

1

true

Family

RhoGEF domain-containing protein

RhoGEF_domain

6

IPR053087

53,087

Transmembrane protein 154-like

TMEM154-like

Family

977

true

false

This family of proteins includes transmembrane proteins that are characterized by their spanning of the cellular membrane. The specific functions of these proteins may involve various biological processes, including signal transduction, cellular adhesion, and the transport of molecules across the membrane. Due to the t...

[]

0

[ "PANTHER" ]

[ "PTHR36526" ]

[ "TMEM154-like" ]

[ 977 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 977 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 1, 5 ]

4

true

Family

Transmembrane protein 154-like

TMEM154-like

9

IPR053088

53,088

Cell surface beta-glucosidase/SUN-like

Beta-glucosidase/SUN-like

Family

1,029

true

false

This family of proteins includes members that are involved in cell wall biogenesis. One of the characterized functions within this family is that of a cell surface beta-glucosidase, which plays a role in the remodeling or degradation of cell wall components. The family is also noted for its similarity to the SUN family...

[]

0

[ "PANTHER" ]

[ "PTHR31654" ]

[ "Beta-glucosidase/SUN-like" ]

[ 1029 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1029 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cell surface beta-glucosidase/SUN-like

Beta-glucosidase/SUN-like

6

IPR053089

53,089

Rho guanine nucleotide exchange factor 18

Rho_GEF18

Family

1,280

true

false

The Rho guanine nucleotide exchange factor 18 family includes proteins that function as guanine nucleotide exchange factors (GEFs) for RhoA and RAC1 GTPases. Members of this family are involved in the regulation of the actin cytoskeleton, as their activation leads to the formation of actin stress fibers and induces cha...

[]

0

[ "PANTHER" ]

[ "PTHR47440" ]

[ "Rho_GEF18" ]

[ 1280 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-193648", "R-HSA-2173791", "R-HSA-416482", "R-HSA-8980692", "R-HSA-9013149", "R-MMU-193648", "R-MMU-2173791", "R-MMU-416482", "R-MMU-8980692", "R-MMU-9013149" ]

[ "REACTOME:R-HSA-193648", "REACTOME:R-HSA-2173791", "REACTOME:R-HSA-416482", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013149", "REACTOME:R-MMU-193648", "REACTOME:R-MMU-2173791", "REACTOME:R-MMU-416482", "REACTOME:R-MMU-8980692", "REACTOME:R-MMU-9013149" ]

10

[]

0

[]

0

[]

0

null

[ "Chordata" ]

[ 1280 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 8, 8, 6 ]

4

true

Family

Rho guanine nucleotide exchange factor 18

Rho_GEF18

3

IPR053090

53,090

Centromere-associated KNL-2 homolog

Centromere_KNL-2_homolog

Family

1,271

true

false

This family of proteins is essential for various stages of cell division and development. Members are involved in the recognition and localization of centromeres during mitosis and meiosis, which is crucial for accurate chromosome segregation. They also contribute to the establishment of the epigenetic status of centro...

[]

0

[ "PANTHER" ]

[ "PTHR35311" ]

[ "Centromere_KNL-2_homolog" ]

[ 1271 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Apilactobacillus kunkeei", "Eukaryota" ]

[ 1, 1270 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 8, 7 ]

3

true

Family

Centromere-associated KNL-2 homolog

Centromere_KNL-2_homolog

5

IPR053091

53,091

Photosystem II Assembly and Photoprotection-Related Protein

PSII_Assembly/Photoprotect-Rel

Family

1,124

true

false

This family of proteins includes members that are involved in the photoprotection and assembly of photosystem II (PSII) as well as in the biogenesis and repair processes of PSII. They can form trimeric complexes with other proteins that are essential for the early assembly of PSII and its repair, and are also involved ...

[]

0

[ "PANTHER" ]

[ "PTHR37752" ]

[ "PSII_Assembly/Photoprotect-Rel" ]

[ 1124 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1124 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 17 ]

3

true

Family

Photosystem II Assembly and Photoprotection-Related Protein

PSII_Assembly/Photoprotect-Rel

5

IPR053092

53,092

Mitochondrial protein-disulfide reductase DMO2

DMO2

Family

951

true

This family represents Mitochondrial protein-disulfide reductase DMO2 and related fungal protein. DMO2 is a protein disulfide reductase that introduces disulfide bonds into inner mitochondrial membrane proteins and chaperones their assembly into multimeric protein complexes [ , ]. Ii introduces disulfide bonds into TIM...

[]

0

[ "PANTHER" ]

[ "PTHR28048" ]

[ "Mitochondrial_unc_protein" ]

[ 951 ]

1

[]

0

[]

0

[ "PUB00160264", "PUB00163356" ]

[ "39932033", "39753782" ]

[ "Saccharomyces cerevisiae Dmo2p is required for the stability and maturation of newly translated Cox2p.", "Dbi1 is an oxidoreductase and an assembly chaperone for mitochondrial inner membrane proteins." ]

[ 2025, 2025 ]

2

[]

0

null

[ "Fungi" ]

[ 951 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial protein-disulfide reductase DMO2

DMO2

5

IPR053093

53,093

GPCR-like receptor

GPCR-like

Family

953

true

false

This family of proteins includes members that are putative G-protein coupled receptors (GPCRs). GPCRs constitute a large and diverse group of membrane proteins that play a critical role in signal transduction by responding to a variety of extracellular stimuli and activating intracellular signaling pathways. Although t...

[]

0

[ "PANTHER" ]

[ "PTHR47760" ]

[ "GPCR-like" ]

[ 953 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Protostomia" ]

[ 953 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 6, 2 ]

2

true

Family

GPCR-like receptor

GPCR-like

9

IPR053094

53,094

Zinc metalloprotease ZmpB

Zinc_metalloprotease_ZmpB

Family

672

true

false

This family of proteins includes zinc metalloproteases that are known to play a role in virulence, particularly in the context of bacterial pathogenicity. Members of this family are capable of inducing inflammation in the lower respiratory tract, which is evidenced by the increase of tumor necrosis factor alpha (TNF-al...

[]

0

[ "PANTHER" ]

[ "PTHR48193" ]

[ "Zinc_metalloprotease_ZmpB" ]

[ 672 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 386, 286 ]

2

[]

0

true

Family

Zinc metalloprotease ZmpB

Zinc_metalloprotease_ZmpB

6

IPR053095

53,095

Actin-binding & GATA zinc finger domain-containing protein

Actin-binding/GATA_Znf

Family

1,116

true

This family of proteins includes members that are involved in the regulation of actin cytoskeleton dynamics and transcriptional regulation. One protein in this family is known to bind actin, suggesting a role in the modulation of actin filament assembly and disassembly, which is crucial for various cellular processes s...

[]

0

[ "PANTHER" ]

[ "PTHR23246" ]

[ "Actin-binding/GATA-ZnF_domain" ]

[ 1116 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 16, 1100 ]

2

[ "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3, 4 ]

2

true

Family

Actin-binding & GATA zinc finger domain-containing protein

Actin-binding/GATA_Znf

2

IPR053096

53,096

Cytotoxic and regulatory T-cell molecule

CRTAM

Family

785

true

false

This family of proteins mediates heterophilic cell-cell adhesion and plays a crucial role in the regulation of T-cell activation, differentiation, and tissue retention. Members of this family interact with CADM1 to enhance NK cell cytotoxicity and IFNG secretion by CD8+ T-cells, as well as to facilitate NK cell-mediate...

[]

0

[ "PANTHER" ]

[ "PTHR47118" ]

[ "CRTAM" ]

[ 785 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-198933", "R-MMU-198933" ]

[ "REACTOME:R-HSA-198933", "REACTOME:R-MMU-198933" ]

2

[ "3rbg", "4h5s" ]

2

[]

0

[]

0

null

[ "Deuterostomia" ]

[ 785 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 3 ]

4

true

Family

Cytotoxic and regulatory T-cell molecule

CRTAM

3

IPR053097

53,097

Prespore vesicle-associated protein

Prespore_vesicle_assoc

Family

155

true

false

This family of proteins includes members involved in the formation of prespore vesicles, which are essential for spore coat formation during the developmental process of cellular organisms such as Dictyostelium discoideum. The proteins in this family may play a role in the trafficking and sorting of cargo proteins to t...

[]

0

[ "PANTHER" ]

[ "PTHR34586" ]

[ "Prespore_vesicle_assoc" ]

[ 155 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Noviherbaspirillum album", "unclassified Nimaviridae" ]

[ 151, 1, 3 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Prespore vesicle-associated protein

Prespore_vesicle_assoc

6

IPR053098

53,098

Petuviruses Genome Polyprotein

Petuviruses_polyprotein

Family

2,796

true

false

The Petuviruses genome polyprotein is involved in the life cycle of Petuviruses, a group of plant viruses. The polyproteins encoded by these viruses are processed to produce at least four distinct polypeptides, each with a specific role in the viral infection and replication process: Movement protein (MP), capsid prote...

[]

0

[ "PANTHER" ]

[ "PTHR48435" ]

[ "" ]

[ 2796 ]

1

[]

0

[]

0

[ "PUB00155242" ]

[ "9299626" ]

[ "Petunia vein-clearing virus: a plant pararetrovirus with the core sequences for an integrase function." ]

[ 1997 ]

1

[]

0

null

[ "Caulimoviridae", "Mesangiospermae" ]

[ 6, 2790 ]

2

[ "Arabidopsis thaliana" ]

[ 8 ]

1

true

Family

Petuviruses Genome Polyprotein

Petuviruses_polyprotein

4

IPR053100

53,100

Cytochrome b5-related

Cytochrome_b5-related

Family

856

true

false

This family of proteins includes members that are related to cytochrome b5. Cytochrome b5 proteins are involved in electron transport and play a crucial role in various metabolic processes, including fatty acid desaturation and elongation, and drug metabolism. Members of this family may have a specific function in musc...

[]

0

[ "PANTHER" ]

[ "PTHR16740" ]

[ "Cytochrome_b5-related" ]

[ 856 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Candidatus Kentrum sp. FW", "Eukaryota", "viral metagenome" ]

[ 1, 854, 1 ]

3

[ "Drosophila melanogaster" ]

[ 3 ]

1

true

Family

Cytochrome b5-related

Cytochrome_b5-related

5

IPR053101

53,101

Transmembrane protein 221

TM221

Family

747

true

false

This family of proteins includes transmembrane proteins that are characterized by their spanning of the cellular membrane. The specific functions of these proteins may vary, but they typically play roles in cellular processes such as signaling, transport, and maintaining structural integrity of the cell. As transmembra...

[]

0

[ "PANTHER" ]

[ "PTHR36132" ]

[ "TM221" ]

[ 747 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 747 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 5 ]

4

true

Family

Transmembrane protein 221

TM221

6

IPR053103

53,103

IDLSRF-like signaling peptide

IDLSRF-like_peptide

Family

702

true

false

This family of proteins includes peptides that are likely involved in signaling pathways as prohormones. Prohormones are precursors of hormones, which are processed and cleaved to produce active hormones that participate in various regulatory functions. These proteins may undergo post-translational modifications and cl...

[]

0

[ "PANTHER" ]

[ "PTHR20967" ]

[ "IDLSRF-like_peptide" ]

[ 702 ]

1

[]

0

[ "2kny", "8v14" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 702 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 2, 2 ]

2

true

Family

IDLSRF-like signaling peptide

IDLSRF-like_peptide

1

IPR053104

53,104

Tumor Necrosis Factor Ligand Superfamily Member 8

TNF_ligand_SF_member_8

Family

613

true

false

This family of proteins includes cytokines that are members of the tumor necrosis factor (TNF) superfamily. These proteins are known to interact with the TNFRSF8/CD30 receptor, which is expressed on the surface of certain T-cells. The primary function of these proteins is to induce the proliferation of T-cells, which p...

[]

0

[ "PANTHER" ]

[ "PTHR32163" ]

[ "TNF_ligand_SF_member_8" ]

[ 613 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5669034", "R-MMU-5669034" ]

[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034" ]

2

[]

0

[]

0

[]

0

null

[ "Dipnotetrapodomorpha" ]

[ 613 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 2 ]

3

true

Family

Tumor Necrosis Factor Ligand Superfamily Member 8

TNF_ligand_SF_member_8

7

IPR053105

53,105

Class V-like SAM-binding domain-containing protein

Class_V-like_SAM-MTase

Family

750

true

false

This family of proteins includes histone-lysine N-methyltransferases that are known to modify histones by di- and trimethylation, particularly 'Lys-9' of histone H3. These modifications are crucial for regulating gene expression and are involved in various cellular processes, including modulation of aging and stress re...

[]

0

[ "PANTHER" ]

[ "PTHR47250" ]

[ "Class_V-like_SAM-MTase" ]

[ 750 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydiia", "Eukaryota" ]

[ 3, 747 ]

2

[ "Caenorhabditis elegans" ]

[ 7 ]

1

true

Family

Class V-like SAM-binding domain-containing protein

Class_V-like_SAM-MTase

6