interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR053456 | 53,456 | HTH-type transcriptional regulator LrpA | HTH-LrpA_regulator | Family | 44 | true | false | This family of proteins includes helix-turn-helix (HTH) type transcriptional regulators known as LrpA. Members of this family are involved in the negative regulation of their own transcription. They function by binding DNA and interfering with the recruitment of RNA polymerase (RNAP) to the promoter complex, thus inhib... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040820"
] | [
"HTH-LrpA_regulator"
] | [
44
] | 1 | [] | [] | [] | 0 | [
"1i1g"
] | 1 | [
"PUB00005435",
"PUB00105992",
"PUB00105993"
] | [
"7770911",
"10973967",
"11809882"
] | [
"The eubacterial transcriptional activator Lrp is present in the archaeon Pyrococcus furiosus.",
"An Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus is negatively autoregulated.",
"A Pyrococcus homolog of the leucine-responsive regulatory protein, LrpA, inhibits transcription by abrogat... | [
1995,
2000,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
44
] | 1 | [] | [] | 0 | true | Family | HTH-type transcriptional regulator LrpA | HTH-type transcriptional regulator LrpA | HTH-LrpA_regulator | 8 |
IPR053457 | 53,457 | Sulredoxin-like | SDX-like | Family | 51 | true | false | This family of proteins is characterized by a similarity to sulredoxins, which suggests a potential involvement in cellular redox processes. However, the exact biochemical function of these proteins has not been established, and further research is necessary to elucidate their role in the cell. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041174"
] | [
"SDX-like"
] | [
51
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106220",
"PUB00106221"
] | [
"7730295",
"8910356"
] | [
"Sulredoxin: a novel iron-sulfur protein of the thermoacidophilic archaeon Sulfolobus sp. strain 7 with a Rieske-type [2Fe-2S] center.",
"Redox-linked ionization of sulredoxin, an archaeal Rieske-type [2Fe-2S] protein from Sulfolobus sp. strain 7."
] | [
1995,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
51
] | 1 | [] | [] | 0 | true | Family | Sulredoxin-like | Sulredoxin-like | SDX-like | 6 |
IPR053458 | 53,458 | Class-III Pyridoxal-Phosphate-Dependent Aminotransferase LysJ | Class-III_PLP-Dep_Atrans_LysJ | Family | 48 | true | false | This family of proteins is involved in the biosynthesis of the amino acids arginine and lysine. Members of this family function as transaminases, enzymes that catalyze the transfer of an amino group from a donor to an acceptor molecule, typically utilizing pyridoxal phosphate as a cofactor. These proteins specifically ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045491"
] | [
"Class-III_PLP-Dep_Atrans_LysJ"
] | [
48
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC"
] | [
"2.6.1.118",
"2.6.1.124",
"PWY-3081",
"PWY-7400"
] | [
"EC:2.6.1.118",
"EC:2.6.1.124",
"METACYC:PWY-3081",
"METACYC:PWY-7400"
] | 4 | [] | 0 | [
"PUB00028128",
"PUB00083921"
] | [
"12042311",
"23434852"
] | [
"The Sulfolobus solfataricus Lrp-like protein LysM regulates lysine biosynthesis in response to lysine availability.",
"Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus."
] | [
2002,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
48
] | 1 | [] | [] | 0 | true | Family | Class-III Pyridoxal-Phosphate-Dependent Aminotransferase LysJ | Class-III Pyridoxal-Phosphate-Dependent Aminotransferase LysJ | Class-III_PLP-Dep_Atrans_LysJ | 2 |
IPR053459 | 53,459 | DNA Double-Strand Break Repair Mre11/Rad50 Complex | DSB_Repair_Mre11/Rad50 | Family | 48 | true | false | This family of proteins is involved in the cellular response to DNA double-strand breaks (DSBs), a critical form of DNA damage. Members of this family function as part of a protein complex that includes Rad50 and is essential for the early steps of DSB repair. They exhibit a dual enzymatic activity, possessing both dou... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041031"
] | [
"DSB_Repair_Mre11/Rad50"
] | [
48
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106138"
] | [
"18294364"
] | [
"The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
48
] | 1 | [] | [] | 0 | true | Family | DNA Double-Strand Break Repair Mre11/Rad50 Complex | DNA Double-Strand Break Repair Mre11/Rad50 Complex | DSB_Repair_Mre11/Rad50 | 2 |
IPR053460 | 53,460 | DNA Double-strand Break Repair Helicase | DSB_Repair_Helicase | Family | 48 | true | false | This family of proteins is involved in the cellular response to DNA double-strand breaks (DSBs), a critical type of DNA damage. Members of this family function in DSB repair by collaborating with the NurA nuclease to initiate resection of the 5' DNA strand, thereby generating a 3' single-stranded DNA overhang. This ove... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040937"
] | [
"DSB_Repair_Helicase"
] | [
48
] | 1 | [
"EC",
"EC"
] | [
"5.6.2.3",
"5.6.2.4"
] | [
"EC:5.6.2.3",
"EC:5.6.2.4"
] | 2 | [
"4d2i"
] | 1 | [
"PUB00057530",
"PUB00078094"
] | [
"22135300",
"25420454"
] | [
"Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex.",
"Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea."
] | [
2011,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
48
] | 1 | [] | [] | 0 | true | Family | DNA Double-strand Break Repair Helicase | DNA Double-strand Break Repair Helicase | DSB_Repair_Helicase | 2 |
IPR053462 | 53,462 | Trehalose Synthase Glycosyltransferase | Trehalose_synthase_GT | Family | 23 | true | false | This family of proteins is involved in the synthesis of trehalose, a type of sugar, from ADP-glucose and glucose. The enzymes in this family are capable of catalyzing a reversible reaction, although the equilibrium is significantly biased towards the production of trehalose. While they predominantly use ADP-glucose as ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041139"
] | [
"Trehalose_synthase_GT"
] | [
23
] | 1 | [
"EC",
"METACYC"
] | [
"2.4.1.245",
"PWY-5983"
] | [
"EC:2.4.1.245",
"METACYC:PWY-5983"
] | 2 | [
"2x6q",
"2x6r",
"2xa1",
"2xa2",
"2xa9",
"2xmp"
] | 6 | [
"PUB00106193"
] | [
"15364950"
] | [
"TreT, a novel trehalose glycosyltransferring synthase of the hyperthermophilic archaeon Thermococcus litoralis."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
23
] | 1 | [] | [] | 0 | true | Family | Trehalose Synthase Glycosyltransferase | Trehalose Synthase Glycosyltransferase | Trehalose_synthase_GT | 4 |
IPR053464 | 53,464 | Mevalonate 3,5-bisphosphate decarboxylase | MVD_Decarboxylase | Family | 10 | true | false | This family of proteins catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate. They are involved in an alternative mevalonate pathway, distinct from the classical route, which is utilized by extreme acidophiles of the Thermoplasmatales order. This alternative pathway ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040847"
] | [
"MVD_Decarboxylase"
] | [
10
] | 1 | [
"EC",
"METACYC"
] | [
"4.1.1.110",
"PWY-7524"
] | [
"EC:4.1.1.110",
"METACYC:PWY-7524"
] | 2 | [
"7t71"
] | 1 | [
"PUB00104790"
] | [
"28004831"
] | [
"An Adaptation To Life In Acid Through A Novel Mevalonate Pathway."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoplasmatales"
] | [
10
] | 1 | [] | [] | 0 | true | Family | Mevalonate 3,5-bisphosphate decarboxylase | Mevalonate 3,5-bisphosphate decarboxylase | MVD_Decarboxylase | 8 |
IPR053465 | 53,465 | Bacterial Sortase Class E | Sortase_Class_E | Family | 5,667 | true | false | This family of proteins functions as transpeptidases that anchor surface proteins to the bacterial cell wall. They recognize specific peptide motifs, with a preference for sequences containing Leu-Ala-x-Thr-Gly over Leu-Pro-x-Thr-Gly. These enzymes exhibit substrate specificity that includes cleaving not only the Thr-G... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033747"
] | [
"Sortase_Class_E"
] | [
5667
] | 1 | [] | [] | [] | 0 | [
"5cuw",
"5go5",
"5go6",
"5utt",
"5uus"
] | 5 | [
"PUB00092196"
] | [
"22026821"
] | [
"Sortase enzymes in Gram-positive bacteria."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
5624,
43
] | 2 | [] | [] | 0 | true | Family | Bacterial Sortase Class E | Bacterial Sortase Class E | Sortase_Class_E | 3 |
IPR053466 | 53,466 | L-arabinose transport ATP-binding | L-arabinose_ABC_transporter | Family | 4,499 | true | false | This family of proteins is involved in the transport of L-arabinose across cellular membranes. Members of this family are part of a binding-protein-dependent transport system, which is an ATP-binding cassette (ABC) transporter system. These proteins are likely responsible for the hydrolysis of ATP, which provides the n... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040905"
] | [
"L-arabinose_ABC_transporter"
] | [
4499
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106052"
] | [
"21984786"
] | [
"Characterization of the mmsAB-araD1 (gguABC) genes of Agrobacterium tumefaciens."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
4479,
2,
18
] | 3 | [] | [] | 0 | true | Family | L-arabinose transport ATP-binding | L-arabinose transport ATP-binding | L-arabinose_ABC_transporter | 9 |
IPR053467 | 53,467 | Penicillin-binding protein 2x | PbpX | Family | 1,038 | false | false | This family of proteins represents Penicillin-binding protein 2x from Streptococcus pneumoniae (PbpX) and similar proteins from Streptococcus species. PbpX forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). It is part of the divisome machinery that synthesises the septal cross wa... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038271"
] | [
"strep_PBP2X"
] | [
1038
] | 1 | [] | [] | [] | 0 | [
"1k25",
"1pmd",
"1pyy",
"1qme",
"1qmf",
"1rp5",
"5oau",
"5oiz",
"5oj0",
"5oj1",
"5u47"
] | 11 | [
"PUB00151228"
] | [
"23873916"
] | [
"Effects of low PBP2b levels on cell morphology and peptidoglycan composition in Streptococcus pneumoniae R6."
] | [
2013
] | 1 | [
"IPR050515"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
1038
] | 1 | [] | [] | 0 | true | Family | Penicillin-binding protein 2x | Penicillin-binding protein 2x | PbpX | 3 |
IPR053470 | 53,470 | RNA-guided DNA endonuclease domain-containing protein | RNA-guided_DNA_endonuclease | Family | 837 | true | false | This family of proteins includes RNA-guided DNA endonucleases that are associated with insertion sequence elements. They are characterized by their ability to cleave double-stranded DNA when guided by a specific RNA molecule. The cleavage occurs downstream of a transposon-associated motif, resulting in staggered cuts 1... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038280"
] | [
"RNA-guided_DNA_endonuclease"
] | [
837
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100808"
] | [
"34619744"
] | [
"Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"mine drainage metagenome"
] | [
836,
1
] | 2 | [] | [] | 0 | true | Family | RNA-guided DNA endonuclease domain-containing protein | RNA-guided DNA endonuclease domain-containing protein | RNA-guided_DNA_endonuclease | 1 |
IPR053471 | 53,471 | 2-amino-4-ketopentanoate thiolase beta subunit | AKP_thiolase_beta | Family | 379 | true | true | This family of proteins is involved in the ornithine fermentation pathway [ ]. Members of this family catalyse the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to produce acetyl-CoA and alanine. The reaction is a key step in the conversion of ornithine to various end products. These enzyme... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040741"
] | [
"AKP_thiolase_beta"
] | [
379
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105937"
] | [
"19251850"
] | [
"A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine."
] | [
2009
] | 1 | [
"IPR050214"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"bioreactor metagenome"
] | [
377,
2
] | 2 | [] | [] | 0 | true | Family | 2-amino-4-ketopentanoate thiolase beta subunit | 2-amino-4-ketopentanoate thiolase beta subunit | AKP_thiolase_beta | 8 |
IPR053472 | 53,472 | Diadenylate Cyclase CdaS-like | DAC_CdaS-like | Family | 607 | true | false | This family of proteins includes diadenylate cyclases, enzymes that catalyze the formation of cyclic di-AMP (c-di-AMP) from two ATP molecules. Cyclic di-AMP is a second messenger involved in various cellular processes such as growth, DNA repair, and cell wall homeostasis. Members of this family are characterized by an ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038328"
] | [
"DAC_CdaS-like"
] | [
607
] | 1 | [] | [] | [] | 0 | [
"2fb5"
] | 1 | [
"PUB00079209",
"PUB00084192"
] | [
"24939848",
"26441857"
] | [
"Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production.",
"Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis."
] | [
2014,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
607
] | 1 | [] | [] | 0 | true | Family | Diadenylate Cyclase CdaS-like | Diadenylate Cyclase CdaS-like | DAC_CdaS-like | 5 |
IPR053473 | 53,473 | Bacterial Cell Wall Biosynthesis Protein | Cell_Wall_Biosynth_Protein | Family | 561 | true | false | This family of proteins is involved in bacterial cell wall biosynthesis. They possess a bifunctional mechanism with distinct domains responsible for different stages of peptidoglycan formation. The N-terminal domain functions as a transglycosylase/glycosyltransferase, which is not inhibited by penicillin and is respons... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038276"
] | [
"Cell_Wall_Biosynth_Protein"
] | [
561
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105692"
] | [
"29487215"
] | [
"Phosphorylation-dependent activation of the cell wall synthase PBP2a in <i>Streptococcus pneumoniae</i> by MacP."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
561
] | 1 | [] | [] | 0 | true | Family | Bacterial Cell Wall Biosynthesis Protein | Bacterial Cell Wall Biosynthesis Protein | Cell_Wall_Biosynth_Protein | 4 |
IPR053474 | 53,474 | Metal-staphylopine ABC transporter permease | Staphylopine_ABC_permease | Family | 475 | true | false | This family of proteins is involved in the transport of divalent metal ions across bacterial membranes. They are components of the ABC transporter complex CntABCDF, also known as Opp1, which is responsible for the uptake of metals in complex with the metallophore staphylopine. These proteins play a crucial role in the ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045473"
] | [
"Staphylopine_ABC_permease"
] | [
475
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094621",
"PUB00153452"
] | [
"23279021",
"17496096"
] | [
"The Staphylococcus aureus Opp1 ABC transporter imports nickel and cobalt in zinc-depleted conditions and contributes to virulence.",
"Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus."
] | [
2013,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanosarcina horonobensis HB-1 = JCM 15518",
"Phytophthora cactorum",
"bioreactor metagenome"
] | [
472,
1,
1,
1
] | 4 | [] | [] | 0 | true | Family | Metal-staphylopine ABC transporter permease | Metal-staphylopine ABC transporter permease | Staphylopine_ABC_permease | 2 |
IPR053475 | 53,475 | DNA Protection During Starvation | DPS | Family | 245 | true | false | This family of proteins is involved in the protection of DNA during conditions of stress such as starvation. They function by binding and sequestering intracellular Fe(2+) ions, converting them to Fe(3+) oxyhydroxide mineral. This process is coupled with the detoxification of hydrogen peroxide, as the proteins catalyze... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040955"
] | [
"DPS"
] | [
245
] | 1 | [] | [] | [] | 0 | [
"2clb",
"7stw",
"9cz0",
"9cz8",
"9cz9",
"9e8s"
] | 6 | [
"PUB00081827",
"PUB00106089"
] | [
"16024730",
"16412514"
] | [
"An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus.",
"Dps-like protein from the hyperthermophilic archaeon Pyrococcus furiosus."
] | [
2005,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
199,
36,
10
] | 3 | [] | [] | 0 | true | Family | DNA Protection During Starvation | DNA Protection During Starvation | DPS | 3 |
IPR053476 | 53,476 | SecD/SecF protein-export membrane protein | SecD/SecF_export | Family | 322 | true | false | This family of proteins is involved in the process of protein export across the cell membrane. Members of this family are integral to the translocation machinery that guides newly synthesized proteins from the cytoplasm to their final destinations outside the cell or within the cell membrane. They play a crucial role i... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041305"
] | [
"SecD/SecF_export"
] | [
322
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053868"
] | [
"16452406"
] | [
"Archaeal and bacterial SecD and SecF homologs exhibit striking structural and functional conservation."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
322
] | 1 | [] | [] | 0 | true | Family | SecD/SecF protein-export membrane protein | SecD/SecF protein-export membrane protein | SecD/SecF_export | 7 |
IPR053477 | 53,477 | tRNA Cytidine Acetyltransferase | tRNA_Cytidine_AcTrnsfr | Family | 318 | true | false | This family of proteins includes enzymes that are responsible for the acetylation of cytidine in tRNA molecules. Specifically, they catalyze the formation of N(4)-acetylcytidine at the wobble position of tRNA(Met), which is a modification that can affect the stability and function of the tRNA. These enzymes utilize ace... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041296"
] | [
"tRNA_Cytidine_AcTrnsfr"
] | [
318
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106301"
] | [
"19478918"
] | [
"A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
318
] | 1 | [] | [] | 0 | true | Family | tRNA Cytidine Acetyltransferase | tRNA Cytidine Acetyltransferase | tRNA_Cytidine_AcTrnsfr | 6 |
IPR053478 | 53,478 | 2-alkyl-3-oxoalkanoate reductase | 2-alkyl-3-oxoalkanoate_rdct | Family | 306 | true | false | This family of proteins is involved in the biosynthesis of olefins, a class of hydrocarbons. Members of this family function as enzymes that catalyze a reversible reaction where 2-alkyl-3-oxoalkanoic acids are reduced to 2-alkyl-3-hydroxyalkanoic acids, utilizing NADPH as a cofactor. This reaction is stereospecific, in... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042422"
] | [
"2-alkyl-3-oxoalkanoate_rdct"
] | [
306
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153436"
] | [
"21958090"
] | [
"Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Lysobacteraceae"
] | [
306
] | 1 | [] | [] | 0 | true | Family | 2-alkyl-3-oxoalkanoate reductase | 2-alkyl-3-oxoalkanoate reductase | 2-alkyl-3-oxoalkanoate_rdct | 9 |
IPR053480 | 53,480 | DNA double-strand break repair ATPase | DSB_repair_ATPase | Family | 315 | true | false | This family of proteins is involved in the cellular response to DNA double-strand breaks (DSBs), a critical form of genetic damage. Members of this family function as part of a larger complex, which includes Mre11, and play a key role in the initial steps of DSB repair. They are responsible for controlling the dynamic ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041035"
] | [
"DSB_repair_ATPase"
] | [
315
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076983",
"PUB00106142",
"PUB00106143"
] | [
"19593371",
"11016950",
"20333302"
] | [
"Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.",
"Genome sequence of Halobacterium species NRC-1.",
"The complete genome sequence of Haloferax volcanii DS2, a model archaeon."
] | [
2009,
2000,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
315
] | 1 | [] | [] | 0 | true | Family | DNA double-strand break repair ATPase | DNA double-strand break repair ATPase | DSB_repair_ATPase | 9 |
IPR053481 | 53,481 | MIP/Aquaporin Lactic Acid Transporter | MIP/AQP_LacticAcid_Trans | Family | 272 | true | false | This family of proteins includes transporters that facilitate the transmembrane diffusion of various small molecules. Members of this family are involved in the cellular metabolism of lactic acid, as they transport lactic acid across the cell membrane. Additionally, these proteins can transport other uncharged solutes ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043012"
] | [
"MIP/AQP_LacticAcid_Trans"
] | [
272
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153513"
] | [
"23799297"
] | [
"Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati"
] | [
272
] | 1 | [] | [] | 0 | true | Family | MIP/Aquaporin Lactic Acid Transporter | MIP/Aquaporin Lactic Acid Transporter | MIP/AQP_LacticAcid_Trans | 4 |
IPR053482 | 53,482 | Dihydroxyphenylacetyl-CoA Dioxygenase | DPA-CoA_Dioxygenase | Family | 326 | true | false | This family of proteins is involved in the biosynthesis of nonproteinogenic amino acids that are precursors for the production of antibiotics such as vancomycin and teicoplanin. Members of this family catalyze the conversion of 3,5-dihydroxyphenylacetyl-CoA to 3,5-dihydroxyphenylglyoxylate, performing a four-electron o... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042432"
] | [
"DPA-CoA_Dioxygenase"
] | [
326
] | 1 | [] | [] | [] | 0 | [
"2np9",
"2pg8",
"4ylh",
"5kag",
"5kah",
"5kaj"
] | 6 | [
"PUB00014465",
"PUB00042007",
"PUB00048676"
] | [
"11752437",
"17507985",
"18004875"
] | [
"Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.",
"Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.",
"Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC."
] | [
2001,
2007,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"prokaryotic environmental samples"
] | [
323,
3
] | 2 | [] | [] | 0 | true | Family | Dihydroxyphenylacetyl-CoA Dioxygenase | Dihydroxyphenylacetyl-CoA Dioxygenase | DPA-CoA_Dioxygenase | 2 |
IPR053484 | 53,484 | Malate Synthase | MS | Family | 158 | true | true | Malate synthase (MS) catalyses the formation of malate through a two-step process. Initially, they facilitate the reversible condensation of acetyl-coenzyme A (acetyl-CoA) with glyoxylate to produce an intermediate, which is then hydrolysed to yield malate and coenzyme A (CoA). While the enzymes can also condense other... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041315"
] | [
"Malate_Synthase-like_Aldolase"
] | [
158
] | 1 | [] | [] | [] | 0 | [
"3oyx",
"3oyz",
"3pug",
"5tao"
] | 4 | [
"PUB00058821",
"PUB00089819",
"PUB00106323"
] | [
"21569248",
"9738442",
"11513957"
] | [
"Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.",
"Operation of glyoxylate cycle in halophilic archaea: presence of malate synthase and isocitrate lyase in Haloferax volcanii.",
"Sequencing, phylogenetic and transcriptional analysis of ... | [
2011,
1998,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
158
] | 1 | [] | [] | 0 | true | Family | Malate Synthase | Malate Synthase | MS | 6 |
IPR053486 | 53,486 | Outer membrane lipoprotein MapA | MapA | Family | 183 | true | true | This family of proteins includes outer membrane lipoproteins, commonly referred to as MapA. These proteins are typically found in the outer membrane of Gram-negative bacteria and are involved in various functions related to the integrity and maintenance of the cell envelope. They may play roles in cell adhesion, invasi... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF041252",
"PF28194"
] | [
"MapA_lipoprotein",
"MapA_lipoprotein"
] | [
133,
183
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106267"
] | [
"7790451"
] | [
"Identification of Campylobacter jejuni on the basis of a species-specific gene that encodes a membrane protein."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Campylobacter"
] | [
183
] | 1 | [] | [] | 0 | true | Family | Outer membrane lipoprotein MapA | Outer membrane lipoprotein MapA | MapA | 1 |
IPR053487 | 53,487 | Alpha-glycosidase | Alpha-glycosidase | Family | 82 | true | false | This family of proteins includes enzymes that hydrolyze a variety of alpha-glycoside bonds in di- and trisaccharides, including alpha-1,4; alpha-1,1; alpha-1,2; alpha-1,3; and alpha-1,6 linkages. They exhibit broad specificity, acting on substrates such as maltose, maltotriose, trehalose, sucrose, turanose, melizitose,... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041089"
] | [
"Alpha-glycosidase"
] | [
82
] | 1 | [] | [] | [] | 0 | [
"1obb",
"1vjt",
"3u95",
"6kcx",
"7br4",
"7brf",
"7ctd",
"7ctl",
"7ctm"
] | 9 | [
"PUB00106171"
] | [
"10972187"
] | [
"Thermotoga maritima AglA, an extremely thermostable NAD+-, Mn2+-, and thiol-dependent alpha-glucosidase."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
82
] | 1 | [] | [] | 0 | true | Family | Alpha-glycosidase | Alpha-glycosidase | Alpha-glycosidase | 8 |
IPR053488 | 53,488 | Dihydroorotate dehydrogenase Type 1 | DHODH_Type1 | Family | 79 | true | false | This family of proteins includes enzymes that are involved in the de novo pyrimidine biosynthesis pathway. Specifically, they catalyze the fourth enzymatic step, which is the conversion of dihydroorotate to orotate. This reaction requires NAD(+) as an electron acceptor. Members of this family play a crucial role in the... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041011"
] | [
"DHODH_Type1"
] | [
79
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104093"
] | [
"12142413"
] | [
"Genes of de novo pyrimidine biosynthesis from the hyperthermoacidophilic crenarchaeote Sulfolobus acidocaldarius: novel organization in a bipolar operon."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
79
] | 1 | [] | [] | 0 | true | Family | Dihydroorotate dehydrogenase Type 1 | Dihydroorotate dehydrogenase Type 1 | DHODH_Type1 | 3 |
IPR053489 | 53,489 | NAD(P)-dependent GAP dehydrogenase | NAD(P)-GAP_dehydrogenase | Family | 87 | true | false | This family of proteins includes enzymes that catalyze the irreversible oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3PG) in a non-phosphorylating, NAD(P)-dependent manner. These enzymes exhibit high specificity for D-GAP as a substrate. Regulation of their activity is allosteric, with activatio... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040869"
] | [
"NAD(P)-GAP_dehydrogenase"
] | [
87
] | 1 | [] | [] | [] | 0 | [
"1ky8",
"1uxn",
"1uxp",
"1uxq",
"1uxr",
"1uxt",
"1uxu",
"1uxv"
] | 8 | [
"PUB00058075"
] | [
"15869466"
] | [
"The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
87
] | 1 | [] | [] | 0 | true | Family | NAD(P)-dependent GAP dehydrogenase | NAD(P)-dependent GAP dehydrogenase | NAD(P)-GAP_dehydrogenase | 7 |
IPR053490 | 53,490 | Nodulation factor fucose acetyltransferase | Nod_factor_Fuc_AcT | Family | 65 | true | false | This family of proteins is thought to function as acetyltransferases, with a specific role in modifying the fucose component of nodulation factors. These modifications are likely critical for the proper functioning of nodulation factors, which are signaling molecules essential for the symbiotic relationship between cer... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042426"
] | [
"Nod_factor_Fuc_AcT"
] | [
65
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153626",
"PUB00153627"
] | [
"23499616",
"9922261"
] | [
"Phylogenetic evidence of the transfer of nodZ and nolL genes from Bradyrhizobium to other rhizobia.",
"NolL of Rhizobium sp. strain NGR234 is required for O-acetyltransferase activity."
] | [
2013,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Hyphomicrobiales"
] | [
65
] | 1 | [] | [] | 0 | true | Family | Nodulation factor fucose acetyltransferase | Nodulation factor fucose acetyltransferase | Nod_factor_Fuc_AcT | 1 |
IPR053492 | 53,492 | Cell Division Machinery Component | Cell_Div_Machinery_Comp | Family | 96 | true | false | This family of proteins is involved in cellular division processes. Members of this family are components of the cell division machinery, suggesting a role in the coordination or execution of cell division events. The exact molecular functions and mechanisms by which these proteins contribute to cell division may vary ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041005"
] | [
"Cell_Div_Machinery_Comp"
] | [
96
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00050019",
"PUB00106127"
] | [
"19008417",
"24399085"
] | [
"A role for the ESCRT system in cell division in archaea.",
"Deletion of cdvB paralogous genes of Sulfolobus acidocaldarius impairs cell division."
] | [
2008,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
96
] | 1 | [] | [] | 0 | true | Family | Cell Division Machinery Component | Cell Division Machinery Component | Cell_Div_Machinery_Comp | 9 |
IPR053493 | 53,493 | Thermostable Carboxypeptidase | Thermostable_CP | Family | 50 | true | false | This family of proteins includes enzymes with carboxypeptidase activity, capable of hydrolyzing the terminal peptide bonds at the C-terminus of proteins and peptides. Members of this family exhibit a preference for removing basic, acidic, and aromatic amino acids, and to a lesser extent, aliphatic amino acids from the ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040868"
] | [
"Thermostable_CP"
] | [
50
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106031",
"PUB00106032"
] | [
"1597179",
"7559343"
] | [
"Purification and characterization of a thermostable carboxypeptidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus.",
"Molecular cloning, nucleotide sequence, and expression of a carboxypeptidase-encoding gene from the archaebacterium Sulfolobus solfataricus."
] | [
1992,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
50
] | 1 | [] | [] | 0 | true | Family | Thermostable Carboxypeptidase | Thermostable Carboxypeptidase | Thermostable_CP | 6 |
IPR053494 | 53,494 | Glycosyl Hydrolase 15 Enzymes | GH15_Enzymes | Family | 90 | true | false | This family of proteins includes enzymes that are involved in the hydrolysis of alpha,alpha-trehalose, a disaccharide consisting of two glucose molecules linked by an alpha,alpha-1,1-glycosidic bond. Members of this family function as trehalases, catalyzing the conversion of trehalose into two glucose units. This react... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041084"
] | [
"GH15_Enzymes"
] | [
90
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106167",
"PUB00106168"
] | [
"29574614",
"29642287"
] | [
"Two trehalose-hydrolyzing enzymes from Crenarchaeon Sulfolobus acidocaldarius exhibit distinct activities and affinities toward trehalose.",
"Saci_1816: A Trehalase that Catalyzes Trehalose Degradation in the Thermoacidophilic Crenarchaeon <i>Sulfolobus acidocaldarius</i>."
] | [
2018,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
90
] | 1 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 15 Enzymes | Glycosyl Hydrolase 15 Enzymes | GH15_Enzymes | 4 |
IPR053495 | 53,495 | Avirulence B/C-like | AvrB/C-like | Family | 84 | true | false | This family of proteins includes avirulence factors that are involved in the pathogenicity of certain bacterial strains. These factors are recognized by specific resistance proteins in host plants, leading to the activation of plant defense mechanisms. The interaction between avirulence proteins and plant resistance pr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041403"
] | [
"AvrB/C-like"
] | [
84
] | 1 | [] | [] | [] | 0 | [
"1nh1",
"2nud",
"2nun",
"8twj",
"8two",
"8tws",
"8txf"
] | 7 | [
"PUB00029063",
"PUB00106343",
"PUB00106378"
] | [
"15016364",
"19849782",
"23252460"
] | [
"Crystal structure of the type III effector AvrB from Pseudomonas syringae.",
"The type III effectors of Xanthomonas.",
"The AvrB_AvrC domain of AvrXccC of Xanthomonas campestris pv. campestris is required to elicit plant defense responses and manipulate ABA homeostasis."
] | [
2004,
2009,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
84
] | 1 | [] | [] | 0 | true | Family | Avirulence B/C-like | Avirulence B/C-like | AvrB/C-like | 7 |
IPR053496 | 53,496 | Acryloyl-CoA Reductase Zinc-Containing Alcohol Dehydrogenase | Acryloyl-CoA_Reductase_Zn-ADH | Family | 76 | true | false | This family of proteins is involved in autotrophic carbon fixation processes, specifically through the 3-hydroxypropionate/4-hydroxybutyrate cycle. Members of this family are responsible for the enzymatic reduction of acryloyl-CoA to propionyl-CoA, a reaction that is coupled with the oxidation of NADPH. They exhibit no... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041172"
] | [
"Acryloyl-CoA_Reductase_Zn-ADH"
] | [
76
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106218"
] | [
"19429610"
] | [
"3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
76
] | 1 | [] | [] | 0 | true | Family | Acryloyl-CoA Reductase Zinc-Containing Alcohol Dehydrogenase | Acryloyl-CoA Reductase Zinc-Containing Alcohol Dehydrogenase | Acryloyl-CoA_Reductase_Zn-ADH | 9 |
IPR053497 | 53,497 | Glycosyl Hydrolase 31 Enzymes | GH31_Enzymes | Family | 71 | true | false | This family of proteins includes enzymes with alpha-glucosidase activity, which catalyze the hydrolysis of alpha-glucosidic linkages in polysaccharides and oligosaccharides. These enzymes play a crucial role in the carbohydrate digestion process by converting complex dietary sugars into glucose. Alpha-glucosidases are ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040948"
] | [
"GH31_Enzymes"
] | [
71
] | 1 | [] | [] | [] | 0 | [
"2g3m",
"2g3n"
] | 2 | [
"PUB00106081"
] | [
"9495770"
] | [
"Molecular characterization of the alpha-glucosidase gene (malA) from the hyperthermophilic archaeon Sulfolobus solfataricus."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
71
] | 1 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 31 Enzymes | Glycosyl Hydrolase 31 Enzymes | GH31_Enzymes | 1 |
IPR053498 | 53,498 | Retron-associated ATPase | Retron_ATPase | Family | 74 | true | false | This family of proteins includes probable ATPases that are components of antiviral defense systems known as retrons. Each retron is composed of a non-coding RNA, a reverse transcriptase, an ATPase, and a putative HNH endonuclease. These proteins are involved in conferring protection against specific bacteriophages by s... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041760"
] | [
"Retron_ATPase"
] | [
74
] | 1 | [] | [] | [] | 0 | [
"9e8z",
"9e90",
"9e91",
"9kjx",
"9kjy",
"9kjz",
"9kk1",
"9kk2",
"9nnb",
"9nnh",
"9nnk",
"9o4a"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"hydrothermal vent metagenome"
] | [
72,
2
] | 2 | [] | [] | 0 | true | Family | Retron-associated ATPase | Retron-associated ATPase | Retron_ATPase | 3 |
IPR053499 | 53,499 | HTH-type TrmB transcriptional regulator | HTH-type_TrmB_regulator | Family | 42 | true | false | This family of proteins includes transcriptional regulators that are involved in the control of gene expression. Members of this family are known to bind to DNA, influencing the architecture of the genome and the transcriptional activity of certain genes. They are characterized by a helix-turn-helix (HTH) motif, which ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041141"
] | [
"HTH-type_TrmB_regulator"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"5box",
"5bpd",
"5bpi",
"5bqt"
] | 4 | [
"PUB00106194"
] | [
"21148291"
] | [
"Histone and TK0471/TrmBL2 form a novel heterogeneous genome architecture in the hyperthermophilic archaeon Thermococcus kodakarensis."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | HTH-type TrmB transcriptional regulator | HTH-type TrmB transcriptional regulator | HTH-type_TrmB_regulator | 4 |
IPR053500 | 53,500 | Prolidase archaeal-type | Prolidase_arc | Family | 42 | true | true | This family of proteins includes enzymes that function as dipeptidases, specifically cleaving dipeptides where the C-terminal amino acid is proline and the N-terminal amino acid is nonpolar. These enzymes are part of the M24B peptidase family and are categorized within the archaeal-type prolidase subfamily. Their enzym... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040821"
] | [
"Archaeal_Prolidase"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"1pv9",
"1wy2"
] | 2 | [
"PUB00029991",
"PUB00105994",
"PUB00105995"
] | [
"15005612",
"16243319",
"9733678"
] | [
"Structure of the prolidase from Pyrococcus furiosus.",
"Characterization of the dinuclear metal center of Pyrococcus furiosus prolidase by analysis of targeted mutants.",
"Characterization of native and recombinant forms of an unusual cobalt-dependent proline dipeptidase (prolidase) from the hyperthermophilic ... | [
2004,
2005,
1998
] | 3 | [
"IPR050659"
] | [] | 1 | 0 | 1 | [
"Thermococcaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Prolidase archaeal-type | Prolidase archaeal-type | Prolidase_arc | 1 |
IPR053502 | 53,502 | Magnetosome protein MamM | MamM | Family | 38 | false | false | This family of proteins is involved in the biogenesis of magnetosomes, which are intracellular organelles that allow magnetotactic bacteria to orient themselves along geomagnetic fields. MamM is essential for the stable accumulation of MamB, a key component of the magnetosome membrane. MamM likely play a role in biomin... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033615"
] | [
"CDF_MamM"
] | [
38
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105200",
"PUB00105201",
"PUB00105202",
"PUB00161757"
] | [
"22007638",
"27286560",
"27550551",
"30811856"
] | [
"The cation diffusion facilitator proteins MamB and MamM of Magnetospirillum gryphiswaldense have distinct and complex functions, and are involved in magnetite biomineralization and magnetosome membrane assembly.",
"Genetic and Ultrastructural Analysis Reveals the Key Players and Initial Steps of Bacterial Magnet... | [
2011,
2016,
2016,
2019
] | 4 | [
"IPR050291"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati"
] | [
38
] | 1 | [] | [] | 0 | true | Family | Magnetosome protein MamM | Magnetosome protein MamM | MamM | 6 |
IPR053503 | 53,503 | Clavaminate Synthase | Clavaminate_Synthase | Family | 56 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of clavulanic acid, a secondary metabolite with clinically important antibiotic properties. Members of this family catalyze the oxidative cyclization of proclavaminic acid to clavaminic acid, which is a key step in the biosynthetic pathway. ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043003"
] | [
"Clavaminate_Synthase"
] | [
56
] | 1 | [] | [] | [] | 0 | [
"1drt",
"1dry",
"1ds0",
"1ds1",
"1gvg",
"6vwq",
"6vwr"
] | 7 | [
"PUB00027811",
"PUB00153496",
"PUB00153497"
] | [
"10655615",
"1472501",
"7876185"
] | [
"Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.",
"Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus.",
"Expression and purification of two isozymes of clavaminate synthas... | [
2000,
1992,
1995
] | 3 | [
"IPR050411"
] | [] | 1 | 0 | 1 | [
"Actinomycetes"
] | [
56
] | 1 | [] | [] | 0 | true | Family | Clavaminate Synthase | Clavaminate Synthase | Clavaminate_Synthase | 1 |
IPR053504 | 53,504 | Geranylgeranyl diphosphate synthase | GGPP_synthase | Family | 48 | true | false | This family of proteins includes enzymes that catalyze the biosynthesis of geranylgeranyl diphosphate (GGPP), a key precursor for the production of ether-linked lipids. These enzymes perform the condensation of isopentenyl pyrophosphate with various allylic pyrophosphates, including dimethylallyl diphosphate (DMAPP), g... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041003"
] | [
"GGPP_synthase"
] | [
48
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106125"
] | [
"8182085"
] | [
"Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
48
] | 1 | [] | [] | 0 | true | Family | Geranylgeranyl diphosphate synthase | Geranylgeranyl diphosphate synthase | GGPP_synthase | 8 |
IPR053505 | 53,505 | Pectinesterase | Pectinesterase | Family | 59 | true | false | This family of proteins is involved in the modification of plant cell walls by catalyzing the demethylesterification of pectin, a major component of the plant cell wall. The enzymatic action results in the release of methanol and protons, leading to a decrease in the degree of methylation of pectin. This process is cru... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041896"
] | [
"Pectinesterase"
] | [
59
] | 1 | [] | [] | [] | 0 | [
"1qjv",
"2nsp",
"2nst",
"2nt6",
"2nt9",
"2ntb",
"2ntp",
"2ntq"
] | 8 | [
"PUB00016280",
"PUB00046566",
"PUB00048382"
] | [
"11162105",
"8370537",
"17717531"
] | [
"Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.",
"Characterization and overexpression of the pem gene encoding pectin methylesterase of Erwinia chrysanthemi strain 3937.",
"Molecular basis of the activity of the phytopathogen pectin methylesteras... | [
2001,
1993,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
59
] | 1 | [] | [] | 0 | true | Family | Pectinesterase | Pectinesterase | Pectinesterase | 6 |
IPR053506 | 53,506 | Cyclomaltodextrinase | Cyclomaltodextrinase | Family | 33 | true | false | This family of proteins includes enzymes with cyclomaltodextrinase activity, capable of hydrolyzing alpha-, beta-, and gamma-cyclomaltodextrins as well as linear maltooligosaccharides into smaller sugars such as glucose and maltose. These proteins act by decycling cyclodextrins and releasing glucose from the reducing e... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041090"
] | [
"Cyclomaltodextrinase"
] | [
33
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106172"
] | [
"12127967"
] | [
"A novel amylolytic enzyme from Thermotoga maritima, resembling cyclodextrinase and alpha-glucosidase, that liberates glucose from the reducing end of the substrates."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Thermotogae"
] | [
33
] | 1 | [] | [] | 0 | true | Family | Cyclomaltodextrinase | Cyclomaltodextrinase | Cyclomaltodextrinase | 2 |
IPR053507 | 53,507 | NADP-dependent Glyceraldehyde Dehydrogenase | NADP-Glyceraldehyde_DH | Family | 25 | true | false | This family of proteins includes NADP-dependent dehydrogenases that participate in the non-phosphorylated Entner-Doudoroff (nED) pathway. They exhibit the highest catalytic activity towards various forms of glyceraldehyde, including D,L-glyceraldehyde and D-glyceraldehyde. These enzymes also show activity towards D,L-g... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040792"
] | [
"NADP-Glyceraldehyde_DH"
] | [
25
] | 1 | [] | [] | [] | 0 | [
"5izd",
"5j77",
"5m4x"
] | 3 | [
"PUB00105965",
"PUB00105966"
] | [
"16458304",
"16566751"
] | [
"Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.",
"Identification and characterization of Ther... | [
2006,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"mine drainage metagenome"
] | [
24,
1
] | 2 | [] | [] | 0 | true | Family | NADP-dependent Glyceraldehyde Dehydrogenase | NADP-dependent Glyceraldehyde Dehydrogenase | NADP-Glyceraldehyde_DH | 4 |
IPR053508 | 53,508 | Plant pathogen avirulence protein | Pathogen_avirulence | Family | 47 | true | false | This family of proteins includes members that are involved in the interaction between plant pathogens and their host plants. The proteins in this family are typically secreted by bacterial pathogens and can function as avirulence factors. These factors are recognized by the plant immune system, leading to the activatio... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF041307",
"PF28195"
] | [
"Pathogen_avirulence",
"Pathogen_avirulence"
] | [
42,
47
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106311",
"PUB00106312"
] | [
"20573017",
"2979910"
] | [
"Type III secretion and in planta recognition of the Xanthomonas avirulence proteins AvrBs1 and AvrBsT.",
"The avirulence gene avrBs1 from Xanthomonas campestris pv. vesicatoria encodes a 50-kD protein."
] | [
2001,
1988
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Pycnococcus provasolii"
] | [
46,
1
] | 2 | [] | [] | 0 | true | Family | Plant pathogen avirulence protein | Plant pathogen avirulence protein | Pathogen_avirulence | 1 |
IPR053509 | 53,509 | Glucose-6-phosphate isomerase | GPI | Family | 39 | true | false | This family of proteins includes enzymes that catalyze the reversible isomerization of glucose-6-phosphate into fructose-6-phosphate, a reaction that is a critical step in the glycolysis and gluconeogenesis metabolic pathways. Members of this family are also known to be competitively inhibited by metabolites such as 6-... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040629"
] | [
"GPI"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanococcales"
] | [
39
] | 1 | [] | [] | 0 | true | Family | Glucose-6-phosphate isomerase | Glucose-6-phosphate isomerase | GPI | 3 |
IPR053510 | 53,510 | Tyramine-Glutamate Amide Bond Synthase | Tyramine-Glutamate_Synthase | Family | 37 | true | false | This family of proteins includes enzymes that are responsible for the biosynthesis of amide bonds between aromatic amines and carboxylic acids. Specifically, they catalyze the formation of an amide linkage between tyramine and the gamma carboxy group of L-glutamate, a reaction that results in the production of a tyramy... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040722"
] | [
"Tyramine-Glutamate_Synthase"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074306"
] | [
"25211225"
] | [
"Identification and characterization of a tyramine-glutamate ligase (MfnD) involved in methanofuran biosynthesis."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Methanococcales"
] | [
37
] | 1 | [] | [] | 0 | true | Family | Tyramine-Glutamate Amide Bond Synthase | Tyramine-Glutamate Amide Bond Synthase | Tyramine-Glutamate_Synthase | 1 |
IPR053511 | 53,511 | NiFe/NiFeSe hydrogenase large subunit | NiFe/NiFeSe_hydrogenase_LSU | Family | 35 | true | false | This family of proteins includes large subunits of [NiFe] and [NiFeSe] hydrogenases, which are enzymes that catalyze the reversible oxidation of hydrogen gas (H2). These hydrogenases play a crucial role in microbial energy metabolism, allowing organisms to use H2 as an electron donor or acceptor in various biochemical ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041785"
] | [
"NiFe/NiFeSe_hydrogenase_LSU"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152958",
"PUB00152959"
] | [
"1603063",
"8504827"
] | [
"Methanococcus voltae harbors four gene clusters potentially encoding two [NiFe] and two [NiFeSe] hydrogenases, each of the cofactor F420-reducing or F420-non-reducing types.",
"A novel very small subunit of a selenium containing [NiFe] hydrogenase of Methanococcus voltae is postranslationally processed by cleava... | [
1992,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Methanococcales"
] | [
35
] | 1 | [] | [] | 0 | true | Family | NiFe/NiFeSe hydrogenase large subunit | NiFe/NiFeSe hydrogenase large subunit | NiFe/NiFeSe_hydrogenase_LSU | 6 |
IPR053512 | 53,512 | Magnetosome protein MamD | MamD | Family | 14 | true | true | This family of proteins is involved in the biomineralisation process, specifically in the formation and regulation of magnetite crystals within magnetosomes. Members of this family are implicated in controlling the size and morphology of magnetite crystals, likely by binding iron ions and possibly influencing oxidation... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040916"
] | [
"Magnetosome_regulatory"
] | [
14
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093607",
"PUB00105539",
"PUB00106056",
"PUB00106057",
"PUB00106058",
"PUB00106059",
"PUB00106060",
"PUB00106061",
"PUB00106062",
"PUB00106120",
"PUB00163195"
] | [
"13129949",
"17965152",
"11571158",
"12496282",
"14766587",
"16237001",
"17449609",
"24616719",
"29243866",
"22716969",
"36654913"
] | [
"Characterization of a spontaneous nonmagnetic mutant of Magnetospirillum gryphiswaldense reveals a large deletion comprising a putative magnetosome island.",
"The major magnetosome proteins MamGFDC are not essential for magnetite biomineralization in Magnetospirillum gryphiswaldense but regulate the size of magn... | [
2003,
2008,
2001,
2003,
2004,
2005,
2007,
2014,
2018,
2012,
2023
] | 11 | [
"IPR060722"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota"
] | [
14
] | 1 | [] | [] | 0 | true | Family | Magnetosome protein MamD | Magnetosome protein MamD | MamD | 4 |
IPR053513 | 53,513 | Class-III Pyridoxal-Phosphate Aminotransferase | Class-III_PLP_Aminotransferase | Family | 37 | true | false | This family of proteins is involved in the biosynthesis of the amino acid lysine through the aminoadipate pathway. Members of this family function as aminotransferases that catalyze the transfer of an amino group from L-glutamate to [LysW]-aminoadipate 6-semialdehyde, resulting in the production of [LysW]-gamma-L-lysin... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042418"
] | [
"Class-III_PLP_Aminotransferase"
] | [
37
] | 1 | [] | [] | [] | 0 | [
"1vef",
"1wkg",
"1wkh"
] | 3 | [
"PUB00053254",
"PUB00087134"
] | [
"19620981",
"11489859"
] | [
"Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.",
"Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate."
] | [
2009,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Deinococcota"
] | [
37
] | 1 | [] | [] | 0 | true | Family | Class-III Pyridoxal-Phosphate Aminotransferase | Class-III Pyridoxal-Phosphate Aminotransferase | Class-III_PLP_Aminotransferase | 5 |
IPR053514 | 53,514 | Decorin-Binding | Decorin-Binding | Family | 36 | true | false | This family of proteins is involved in the adherence of bacteria to host tissues. Members of this family have a specific function in binding to the extracellular matrix protein decorin. This interaction is thought to facilitate bacterial adherence to collagen fibers, which is a critical step in the colonization of host... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033720"
] | [
"Decorin-Binding"
] | [
36
] | 1 | [] | [] | [] | 0 | [
"2mvg"
] | 1 | [
"PUB00105264",
"PUB00105265",
"PUB00105270"
] | [
"18507835",
"21628660",
"26275806"
] | [
"Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.",
"Decorin binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu Stricto.",
"Structure of decorin binding protein B from Borrelia burgdorfe... | [
2008,
2011,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
36
] | 1 | [] | [] | 0 | true | Family | Decorin-Binding | Decorin-Binding | Decorin-Binding | 7 |
IPR053515 | 53,515 | HTH-type Archaellar Gene Regulator | HTH-type_ArnR | Family | 28 | true | false | This family of proteins includes transcriptional activators that are characterized by a helix-turn-helix (HTH) motif. Members of this family are involved in the regulation of gene expression related to the structure known as the archaellum, which is analogous to the bacterial flagellum and is important for motility in ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041016"
] | [
"HTH-type_ArnR"
] | [
28
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088324",
"PUB00106132"
] | [
"23461567",
"27731916"
] | [
"The one-component system ArnR: a membrane-bound activator of the crenarchaeal archaellum.",
"ArnS, a kinase involved in starvation-induced archaellum expression."
] | [
2013,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
28
] | 1 | [] | [] | 0 | true | Family | HTH-type Archaellar Gene Regulator | HTH-type Archaellar Gene Regulator | HTH-type_ArnR | 6 |
IPR053516 | 53,516 | Exo-beta-D-glucosaminidase | GLMA | Family | 17 | true | true | This family of proteins includes exo-beta-D-glucosaminidase GLMA from archaea which is involved in the degradation of chitin, a natural polysaccharide. Members of this family are capable of cleaving the non-reducing terminal glycosidic bond of chitooligosaccharides, thereby catalysing the hydrolysis of specific substra... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041127"
] | [
"Exo-beta-D-glucosaminidase"
] | [
17
] | 1 | [] | [] | [] | 0 | [
"5gsl",
"5gsm",
"8oug"
] | 3 | [
"PUB00106185",
"PUB00106186",
"PUB00153978"
] | [
"12923090",
"16912928",
"28130448"
] | [
"Characterization of an exo-beta-D-glucosaminidase involved in a novel chitinolytic pathway from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1.",
"Cloning, expression and characterization of a thermostable exo-beta-D-glucosaminidase from the hyperthermophilic archaeon Pyrococcus horikoshii.",
"... | [
2003,
2006,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
17
] | 1 | [] | [] | 0 | true | Family | Exo-beta-D-glucosaminidase | Exo-beta-D-glucosaminidase | GLMA | 7 |
IPR053517 | 53,517 | Magnetite Biomineralization Domain-Containing Protein | Magnetite_Biomin-Domain | Family | 7 | true | false | This family of proteins is involved in the biomineralization process of magnetite, a type of iron oxide. Members of this family promote the formation of magnetite under iron-rich conditions where magnetite does not form easily. They have the ability to bind both ferrous (Fe(2+)) and ferric (Fe(3+)) ions. These proteins... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040917"
] | [
"Magnetite_Biomin-Domain"
] | [
7
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106057"
] | [
"12496282"
] | [
"A novel protein tightly bound to bacterial magnetic particles in Magnetospirillum magneticum strain AMB-1."
] | [
2003
] | 1 | [
"IPR060722"
] | [] | 1 | 0 | 1 | [
"Rhodospirillales"
] | [
7
] | 1 | [] | [] | 0 | true | Family | Magnetite Biomineralization Domain-Containing Protein | Magnetite Biomineralization Domain-Containing Protein | Magnetite_Biomin-Domain | 7 |
IPR053518 | 53,518 | Cytochrome P450 119-like | CYP450_119-like | Family | 9 | true | false | This family of proteins includes enzymes that are part of the cytochrome P450 superfamily, which are involved in the metabolism of a wide range of substrates through oxidation reactions. Members of this family have not been characterized with a specific endogenous substrate but are known to catalyze various oxidation r... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041177"
] | [
"CYP450_119-like"
] | [
9
] | 1 | [] | [] | [] | 0 | [
"1f4t",
"1f4u",
"1io7",
"1io8",
"1io9",
"1ue8",
"3b4x",
"4tt5",
"4tuv",
"4wpd",
"4wqj",
"5bv5",
"7uor"
] | 13 | [
"PUB00031744"
] | [
"15219985"
] | [
"Structure and direct electrochemistry of cytochrome P450 from the thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain 7."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
9
] | 1 | [] | [] | 0 | true | Family | Cytochrome P450 119-like | Cytochrome P450 119-like | CYP450_119-like | 4 |
IPR053520 | 53,520 | Transposase_Tn903 | Transposase_Tn903 | Family | 5,673 | true | false | This family of proteins includes enzymes that are essential for the mobilization of transposon Tn903. Members of this family are responsible for catalyzing the movement of the transposon from one location in the genome to another, a process known as transposition. The activity of these proteins is crucial for the propa... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033579"
] | [
"Transposase_Tn903"
] | [
5673
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
933,
4670,
4,
6,
60
] | 5 | [] | [] | 0 | true | Family | Transposase_Tn903 | Transposase_Tn903 | Transposase_Tn903 | 4 |
IPR053521 | 53,521 | Microcin J25-processing enzyme | McjB-like | Family | 3,508 | true | false | This family of proteins includes enzymes that are involved in the post-translational modification of peptide antibiotics, specifically the microcin J25. Members of this family work in conjunction with other proteins to convert inactive precursor peptides into their active forms, which exhibit antimicrobial activity. Th... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033537"
] | [
"McjB-like"
] | [
3508
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105155",
"PUB00105162"
] | [
"26079760",
"27800552"
] | [
"Lasso peptides: an intriguing class of bacterial natural products.",
"Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA."
] | [
2015,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Opisthokonta",
"metagenomes"
] | [
3434,
49,
3,
22
] | 4 | [] | [] | 0 | true | Family | Microcin J25-processing enzyme | Microcin J25-processing enzyme | McjB-like | 5 |
IPR053522 | 53,522 | RNA-guided DNA endonuclease TnpB-like | RNA-guided_endonuclease_TnpB | Family | 2,244 | true | false | This family of proteins includes RNA-guided DNA endonucleases that are part of insertion sequence elements. They are characterized by a C-terminal domain related to the transposase 35 family and an N-terminal domain associated with the transposase 2 family. These endonucleases are guided by small RNAs derived from the ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038281"
] | [
"RNA-guided_endonuclease_TnpB"
] | [
2244
] | 1 | [] | [] | [] | 0 | [
"8bf8",
"8ex9",
"8exa",
"8h1j"
] | 4 | [
"PUB00100808",
"PUB00105183",
"PUB00105695",
"PUB00105696"
] | [
"34619744",
"22367867",
"23461641",
"32365520"
] | [
"Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.",
"Exploring bacterial insertion sequences with ISfinder: objectives, uses, and future developments.",
"ISDra2 transposition in Deinococcus radiodurans is downregulated by TnpB.",
"Characterization of the IS200/IS605 Insertion Sequence... | [
2021,
2012,
2013,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomicrobia",
"Popillia japonica",
"Viruses",
"ecological metagenomes"
] | [
2089,
121,
1,
27,
6
] | 5 | [] | [] | 0 | true | Family | RNA-guided DNA endonuclease TnpB-like | RNA-guided DNA endonuclease TnpB-like | RNA-guided_endonuclease_TnpB | 5 |
IPR053523 | 53,523 | Oligopeptide Permease AppC-like | Oligopeptide_permease_AppC | Family | 1,817 | true | false | This family of proteins is involved in the transport of oligopeptides across the cell membrane. They are part of a binding protein-dependent transport system, specifically adapted to recognize and translocate oligopeptides rather than tripeptides. These proteins play a crucial role in various cellular processes, includ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045476"
] | [
"Oligopeptide_permease_AppC"
] | [
1817
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153452",
"PUB00153549"
] | [
"17496096",
"7997159"
] | [
"Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.",
"Identification of a second oligopeptide transport system in Bacillus subtilis and determination of its role in sporulation."
] | [
2007,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
1814,
3
] | 2 | [] | [] | 0 | true | Family | Oligopeptide Permease AppC-like | Oligopeptide Permease AppC-like | Oligopeptide_permease_AppC | 7 |
IPR053524 | 53,524 | Aerial hyphae-associated peptide synthase | Aerial_hyphae_peptide-synth | Family | 1,915 | true | false | This family of proteins includes enzymes that are likely involved in the biosynthesis of small peptide molecules with roles in morphological development. Specifically, the family is associated with the synthesis of a molecule necessary for the formation of aerial hyphae in certain bacteria. Members of this family are t... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038151"
] | [
"Aerial_hyphae_peptide-synth"
] | [
1915
] | 1 | [] | [] | [] | 0 | [
"8sam",
"8sao",
"8sap",
"9ugq"
] | 4 | [
"PUB00105579"
] | [
"32493223"
] | [
"Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"mine drainage metagenome"
] | [
1914,
1
] | 2 | [] | [] | 0 | true | Family | Aerial hyphae-associated peptide synthase | Aerial hyphae-associated peptide synthase | Aerial_hyphae_peptide-synth | 9 |
IPR053525 | 53,525 | Bacterial Sortase Class D | Sortase_D | Family | 1,419 | true | false | This family of proteins functions as transpeptidases that anchor surface proteins to the bacterial cell wall. They recognize and cleave a specific C-terminal sorting signal in their substrates, forming a covalent intermediate via a thioester bond. This intermediate is subsequently attached to the cell wall. Members of ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033746"
] | [
"Sortase_D"
] | [
1419
] | 1 | [] | [] | [] | 0 | [
"2ln7"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"freshwater metagenome"
] | [
1416,
3
] | 2 | [] | [] | 0 | true | Family | Bacterial Sortase Class D | Bacterial Sortase Class D | Sortase_D | 5 |
IPR053526 | 53,526 | 5-oxoprolinase catalytic subunit | 5-oxoprolinase_subunit | Family | 1,195 | true | false | This family of proteins includes enzymes that are involved in the metabolic breakdown of 5-oxoproline, an intermediate in the gamma-glutamyl cycle. Members of this family function to catalyze the conversion of 5-oxoproline to L-glutamate, a process that is coupled with the hydrolysis of ATP to ADP and inorganic phospha... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045499"
] | [
"5-oxoprolinase_subunit"
] | [
1195
] | 1 | [] | [] | [] | 0 | [
"5dud"
] | 1 | [
"PUB00088732"
] | [
"28830929"
] | [
"Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadota"
] | [
2,
1193
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 5-oxoprolinase catalytic subunit | 5-oxoprolinase catalytic subunit | 5-oxoprolinase_subunit | 3 |
IPR053527 | 53,527 | Tetrathionate-responsive sensor kinase | Tetrathionate_sensor_kinase | Family | 949 | true | false | This family of proteins includes sensor histidine kinases involved in two-component regulatory systems, specifically for the regulation of tetrathionate reductase synthesis. These proteins are typically autophosphorylated in response to environmental signals such as tetrathionate and subsequently transfer the phosphate... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040750"
] | [
"Tetrathionate_sensor_kinase"
] | [
949
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104955"
] | [
"10231485"
] | [
"The genetic basis of tetrathionate respiration in Salmonella typhimurium."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
949
] | 1 | [] | [] | 0 | true | Family | Tetrathionate-responsive sensor kinase | Tetrathionate-responsive sensor kinase | Tetrathionate_sensor_kinase | 2 |
IPR053528 | 53,528 | Thiolase-like Beta-ketothiolase | Thiolase-like_BktB | Family | 699 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of polyhydroxyalkanoates, which are biodegradable polyesters. Members of this family function by catalyzing the Claisen condensation of acetyl-CoA with propionyl-CoA to produce beta-ketovaleryl-CoA, as well as the condensation of two molecul... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042999"
] | [
"Thiolase-like_BktB"
] | [
699
] | 1 | [] | [] | [] | 0 | [
"4nzs",
"4w61",
"9bwk",
"9bwl",
"9bwo",
"9bwp"
] | 6 | [
"PUB00104346"
] | [
"9555876"
] | [
"Multiple beta-ketothiolases mediate poly(beta-hydroxyalkanoate) copolymer synthesis in Ralstonia eutropha."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Burkholderiales",
"plant metagenome"
] | [
696,
3
] | 2 | [] | [] | 0 | true | Family | Thiolase-like Beta-ketothiolase | Thiolase-like Beta-ketothiolase | Thiolase-like_BktB | 7 |
IPR053529 | 53,529 | Peptidase M23B | Peptidase_M23B | Family | 867 | true | false | This family of proteins includes peptidases that are part of the M23B subfamily. Members of this family are typically involved in the cleavage of peptide bonds in specific substrates. They may play a role in bacterial cell wall metabolism by cleaving the peptide cross-links between glycan chains, which is crucial for c... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040883"
] | [
"Peptidase_M23B"
] | [
867
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106043"
] | [
"33660879"
] | [
"ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
867
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Peptidase M23B | Peptidase M23B | Peptidase_M23B | 1 |
IPR053530 | 53,530 | Bacterial ABC transporter arginine-binding | ABC_transporter_arg-binding | Family | 753 | true | false | This family of proteins includes components of the ABC transporter complex that are involved in the transport of arginine. Members of this family have a high affinity for binding L-arginine, a key amino acid in various metabolic processes. These proteins are integral to the proper functioning of the ABC transporter sys... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041765"
] | [
"ABC_transporter_arg-binding"
] | [
753
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152883"
] | [
"30698741"
] | [
"The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
753
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterial ABC transporter arginine-binding | Bacterial ABC transporter arginine-binding | ABC_transporter_arg-binding | 8 |
IPR053531 | 53,531 | RCS-specific HTH-type transcriptional activator | RCS-HTH_transactivator | Family | 710 | true | false | This family of proteins includes transcriptional activators that respond to oxidative stress conditions. They are characterized by the presence of a helix-turn-helix (HTH) motif specific to the RCS system, which is involved in the regulation of their DNA-binding activity. The proteins in this family play a crucial role... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040475"
] | [
"RCS-HTH_transactivator"
] | [
710
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085116"
] | [
"24078635"
] | [
"The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Protostomia",
"Pseudomonadota"
] | [
2,
708
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | RCS-specific HTH-type transcriptional activator | RCS-specific HTH-type transcriptional activator | RCS-HTH_transactivator | 7 |
IPR053532 | 53,532 | Reactive Chlorine Species Resistance Protein | RCS_Resistance | Family | 692 | true | false | This family of proteins is implicated in the cellular response to oxidative stress, specifically in the defense against reactive chlorine species (RCS). Members of this family are thought to play a role in the resistance mechanism that protects the cell from the damaging effects of RCS, which can include modifications ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040476"
] | [
"RCS_Resistance"
] | [
692
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085116"
] | [
"24078635"
] | [
"The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
692
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Reactive Chlorine Species Resistance Protein | Reactive Chlorine Species Resistance Protein | RCS_Resistance | 5 |
IPR053533 | 53,533 | HTH-type transcriptional regulator YgbI-like | HTH-type_regulator_YgbI-like | Family | 686 | true | false | This family of proteins includes transcriptional regulators that feature a helix-turn-helix (HTH) motif. The HTH motif is a common DNA-binding domain that enables the protein to interact with specific DNA sequences, typically in the promoter regions of genes, to regulate transcription. As transcriptional regulators, th... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040890"
] | [
"HTH-type_regulator_YgbI-like"
] | [
686
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106047"
] | [
"30137486"
] | [
"Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
686
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | HTH-type transcriptional regulator YgbI-like | HTH-type transcriptional regulator YgbI-like | HTH-type_regulator_YgbI-like | 3 |
IPR053534 | 53,534 | Tetrathionate response regulator | Tetrathionate_resp_reg | Family | 608 | true | false | This family of proteins includes transcriptional regulators that are part of two-component systems, typically comprising a sensor kinase and a response regulator. Members of this family are involved in the regulation of operons responsible for the reduction of tetrathionate. They function as activators of gene transcri... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040749"
] | [
"Tetrathionate_resp_reg"
] | [
608
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104955"
] | [
"10231485"
] | [
"The genetic basis of tetrathionate respiration in Salmonella typhimurium."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
608
] | 1 | [] | [] | 0 | true | Family | Tetrathionate response regulator | Tetrathionate response regulator | Tetrathionate_resp_reg | 1 |
IPR053536 | 53,536 | Lasso peptide isopeptidase | Lasso_peptide_isopeptidase | Family | 309 | true | false | This family of proteins includes isopeptidases that specialize in the hydrolysis of lasso peptides, such as Astexin-2 and Astexin-3. These enzymes recognize and bind to the unique knotted structure of lasso peptides, particularly focusing on the loop structure. Upon binding, they facilitate the opening of the lasso pep... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033523"
] | [
"Lasso_peptide_isopeptidase"
] | [
309
] | 1 | [] | [] | [] | 0 | [
"5txc",
"5txe"
] | 2 | [
"PUB00105157",
"PUB00105158",
"PUB00105159",
"PUB00105160"
] | [
"28696674",
"23862624",
"26534965",
"27998080"
] | [
"Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch.",
"Discovery and characterization of an isopeptidase that linearizes lasso peptides.",
"Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase.",
"Structure of the Lasso Peptide Isopeptidase Identifies a Topology ... | [
2017,
2013,
2015,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Dorcoceras hygrometricum",
"Pseudomonadota",
"plant metagenome"
] | [
1,
305,
3
] | 3 | [] | [] | 0 | true | Family | Lasso peptide isopeptidase | Lasso peptide isopeptidase | Lasso_peptide_isopeptidase | 7 |
IPR053537 | 53,537 | DNA-guanine Transglycosylase | DNA-guanine_TGase | Family | 374 | true | false | This family of proteins is involved in the modification of DNA by inserting 7-deazaguanine derivatives. Members of this family are implicated in the synthesis of modified nucleosides such as 7-cyano-7-deazaguanine (preQ0) and 2'-deoxy-7-cyano-7-deazaguanosine (dPreQ0) in DNA. These modifications are carried out through... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041059"
] | [
"DNA-guanine_TGase"
] | [
374
] | 1 | [] | [] | [] | 0 | [
"7ui4"
] | 1 | [
"PUB00101146",
"PUB00101147"
] | [
"30159947",
"26929322"
] | [
"Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery.",
"Novel genomic island modifies DNA with 7-deazaguanine derivatives."
] | [
2018,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
6,
363,
5
] | 3 | [] | [] | 0 | true | Family | DNA-guanine Transglycosylase | DNA-guanine Transglycosylase | DNA-guanine_TGase | 8 |
IPR053538 | 53,538 | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase | MurL_epimerase | Family | 395 | true | false | This family of proteins is involved in bacterial cell wall biosynthesis. Members of this family are responsible for the epimerization of the terminal L-glutamate residue in the precursor UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. This epimerization step is crucial for the proper assembly and structure of the p... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041275"
] | [
"MurL_epimerase"
] | [
395
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094462",
"PUB00106285"
] | [
"28294606",
"34114638"
] | [
"A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.",
"Discovery of an alternative pathway of peptidoglycan biosynthesis: A new target for pathway specific inhibitors."
] | [
2017,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Knufia peltigerae",
"Lysobacterales",
"mine drainage metagenome"
] | [
1,
393,
1
] | 3 | [] | [] | 0 | true | Family | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase | UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase | MurL_epimerase | 9 |
IPR053540 | 53,540 | Bisanhydrobacterioruberin Hydratase | BABR_hydratase | Family | 325 | true | false | This family of proteins is involved in the biosynthesis of bacterioruberin, an acyclic C50 carotenoid. Members of this family function as enzymes that catalyze the introduction of hydroxyl groups at specific positions on the precursor molecule bisanhydrobacterioruberin, leading to the formation of bacterioruberin. The ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041333"
] | [
"BABR_hydratase"
] | [
325
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00077981"
] | [
"25712483"
] | [
"Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
325
] | 1 | [] | [] | 0 | true | Family | Bisanhydrobacterioruberin Hydratase | Bisanhydrobacterioruberin Hydratase | BABR_hydratase | 8 |
IPR053541 | 53,541 | Polyprenyl diphosphate synthase | Polyprenyl_diphosphate_synth | Family | 335 | true | false | This family of proteins is involved in the biosynthesis of polyprenyl diphosphates, which are key precursors for the synthesis of isoprenoids, a diverse class of biological molecules. Members of this family function as enzymes that catalyze the condensation of isopentenyl pyrophosphate (IPP) with allylic diphosphates s... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042417"
] | [
"Polyprenyl_diphosphate_synth"
] | [
335
] | 1 | [] | [] | [] | 0 | [
"9imq",
"9imr",
"9ims",
"9kuq"
] | 4 | [
"PUB00153500"
] | [
"32495977"
] | [
"Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Mycobacteriaceae"
] | [
335
] | 1 | [] | [] | 0 | true | Family | Polyprenyl diphosphate synthase | Polyprenyl diphosphate synthase | Polyprenyl_diphosphate_synth | 3 |
IPR053542 | 53,542 | Diadenylate Cyclase DacZ | Diadenylate_Cyclase_DacZ | Family | 325 | true | false | This family of proteins includes enzymes known as diadenylate cyclases, which are responsible for the synthesis of cyclic di-AMP (c-di-AMP) from ATP. Cyclic di-AMP acts as a second messenger in various cellular processes, including osmoregulation. Members of this family are crucial for the survival of certain organisms... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041371"
] | [
"Diadenylate_Cyclase_DacZ"
] | [
325
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098861"
] | [
"30884174"
] | [
"Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
325
] | 1 | [] | [] | 0 | true | Family | Diadenylate Cyclase DacZ | Diadenylate Cyclase DacZ | Diadenylate_Cyclase_DacZ | 1 |
IPR053543 | 53,543 | Bacterial Reverse Transcriptase | Bacterial_RT | Family | 304 | true | false | This family of proteins includes reverse transcriptases that are part of bacterial antiviral defense systems known as retrons. These enzymes are responsible for the synthesis of multicopy single-stranded DNA (msDNA), which is a branched molecule consisting of RNA linked to single-stranded DNA. The retron-encoded RNA se... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038237"
] | [
"Bacterial_RT"
] | [
304
] | 1 | [] | [] | [] | 0 | [
"9lm3"
] | 1 | [
"PUB00101106"
] | [
"33157039"
] | [
"Bacterial Retrons Function In Anti-Phage Defense."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
303,
1
] | 2 | [] | [] | 0 | true | Family | Bacterial Reverse Transcriptase | Bacterial Reverse Transcriptase | Bacterial_RT | 8 |
IPR053544 | 53,544 | HMG-CoA Synthase-like | HMG-CoA_Synthase-like | Family | 319 | true | false | This family of proteins includes enzymes that are responsible for a key step in the mevalonate pathway, which is crucial for the biosynthesis of isoprenoids. These enzymes catalyze the formation of 3-hydroxy-3-methylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. Isoprenoids are vital components of archaeal membrane ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041302"
] | [
"HMG-CoA_Synthase-like"
] | [
319
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106306"
] | [
"23794621"
] | [
"Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales",
"Longimonas halophila"
] | [
318,
1
] | 2 | [] | [] | 0 | true | Family | HMG-CoA Synthase-like | HMG-CoA Synthase-like | HMG-CoA_Synthase-like | 7 |
IPR053545 | 53,545 | Enoyl-CoA Hydratase-like | Enoyl-CoA_hydratase-like | Family | 366 | true | false | This family of proteins is involved in the biosynthesis of specific nonproteinogenic amino acids that are crucial components of certain antibiotics, such as vancomycin and teicoplanin. Members of this family function by catalyzing the addition of water to enoyl-CoA thioesters, resulting in beta-hydroxyacyl-CoA thioeste... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042431"
] | [
"Enoyl-CoA_hydratase-like"
] | [
366
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014465"
] | [
"11752437"
] | [
"Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"prokaryotic environmental samples"
] | [
363,
3
] | 2 | [] | [] | 0 | true | Family | Enoyl-CoA Hydratase-like | Enoyl-CoA Hydratase-like | Enoyl-CoA_hydratase-like | 9 |
IPR053546 | 53,546 | Nre DNA repair-associated | Nre_DNA_repair | Family | 311 | true | false | This family of proteins is involved in the cellular response to DNA damage, particularly in the repair mechanisms that address lesions caused by mitomycin C, a DNA damaging agent. Members of this family function in concert with the UvrABC repair system to correct DNA damage, ensuring genomic integrity and cell survival... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041387"
] | [
"Nre_DNA_repair"
] | [
311
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00077939"
] | [
"26337406"
] | [
"A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
311
] | 1 | [] | [] | 0 | true | Family | Nre DNA repair-associated | Nre DNA repair-associated | Nre_DNA_repair | 5 |
IPR053547 | 53,547 | Multiheme cytochrome c menaquinone reductase | Multiheme_cyt_c_menaq_reduct | Family | 109 | true | false | This family of proteins includes components of the respiratory Qrc complex, which are involved in the electron transfer process essential for sulfate respiration. They facilitate the reduction of the menaquinone pool, utilizing electrons from reduced periplasmic cytochrome c3. These proteins are likely crucial for micr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041781"
] | [
"Multiheme_cyt_c_menaq_reduct"
] | [
109
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088946",
"PUB00152939"
] | [
"20498375",
"21651911"
] | [
"The Qrc membrane complex, related to the alternative complex III, is a menaquinone reductase involved in sulfate respiration.",
"EPR characterization of the new Qrc complex from sulfate reducing bacteria and its ability to form a supercomplex with hydrogenase and TpIc3."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
105,
4
] | 2 | [] | [] | 0 | true | Family | Multiheme cytochrome c menaquinone reductase | Multiheme cytochrome c menaquinone reductase | Multiheme_cyt_c_menaq_reduct | 2 |
IPR053548 | 53,548 | Chemotaxis signal transducer CheY | CheY_signal_transducer | Family | 279 | true | false | This family of proteins is involved in the relay of sensory signals to cellular motility apparatus. Members of this family act as intermediaries that communicate environmental cues from sensory receptors, which detect changes in chemical gradients or light, to the machinery responsible for locomotion, such as flagellar... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041367"
] | [
"CheY_signal_transducer"
] | [
279
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106340",
"PUB00106359"
] | [
"23171228",
"8636990"
] | [
"The protein interaction network of a taxis signal transduction system in a halophilic archaeon.",
"Deletion analysis of the che operon in the archaeon Halobacterium salinarium."
] | [
2012,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
279
] | 1 | [] | [] | 0 | true | Family | Chemotaxis signal transducer CheY | Chemotaxis signal transducer CheY | CheY_signal_transducer | 2 |
IPR053549 | 53,549 | Menaquinone reductase, integral membrane subunit | QrcD | Family | 120 | false | false | This family of proteins mainly found in Thermodesulfobacteriota includes Menaquinone reductase, integral membrane subunit from Nitratidesulfovibrio vulgaris (QrcD), QrcD is a component of the respiratory Qrc complex, that catalyses the reduction of the menaquinone pool using electrons transferred from the reduced perip... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041784"
] | [
"mnquin_red_QrcD"
] | [
120
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088946",
"PUB00152939"
] | [
"20498375",
"21651911"
] | [
"The Qrc membrane complex, related to the alternative complex III, is a menaquinone reductase involved in sulfate respiration.",
"EPR characterization of the new Qrc complex from sulfate reducing bacteria and its ability to form a supercomplex with hydrogenase and TpIc3."
] | [
2010,
2011
] | 2 | [
"IPR052049"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"hydrocarbon metagenome"
] | [
119,
1
] | 2 | [] | [] | 0 | true | Family | Menaquinone reductase, integral membrane subunit | Menaquinone reductase, integral membrane subunit | QrcD | 5 |
IPR053550 | 53,550 | Cyclic nucleotide synthase CD-NTase | CD-NTase | Family | 258 | true | false | This family of proteins includes cyclic nucleotide synthases involved in the synthesis of cyclic oligonucleotides, which function as second messengers within bacterial CBASS antiviral systems. These enzymes catalyze the formation of 3',3',3'-cyclic AMP-AMP-AMP and other cyclic nucleotides, which activate effectors that... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041117"
] | [
"CD-NTase"
] | [
258
] | 1 | [] | [] | [] | 0 | [
"6p82",
"6p8j",
"6p8u",
"9ntn",
"9nto"
] | 5 | [
"PUB00096608",
"PUB00096653",
"PUB00106182"
] | [
"32839535",
"31533127",
"30787435"
] | [
"Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems.",
"Cyclic GMP-AMP signalling protects bacteria against viral infection.",
"Bacterial cGAS-like enzymes synthesize diverse nucleotide signals."
] | [
2020,
2019,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"metagenomes"
] | [
228,
21,
9
] | 3 | [] | [] | 0 | true | Family | Cyclic nucleotide synthase CD-NTase | Cyclic nucleotide synthase CD-NTase | CD-NTase | 4 |
IPR053552 | 53,552 | Menaquinone reductase iron-sulfur cluster-binding subunit | QrcC | Family | 113 | true | true | This family of proteins is involved in the electron transfer process within the respiratory Qrc complex, which is responsible for the reduction of menaquinone. These proteins are crucial for the utilization of electrons from reduced periplasmic cytochrome c3 during sulfate respiration [ ]. They play a key role in energ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041782"
] | [
"Menaquinone_reductase_QrcC"
] | [
113
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088946",
"PUB00152939"
] | [
"20498375",
"21651911"
] | [
"The Qrc membrane complex, related to the alternative complex III, is a menaquinone reductase involved in sulfate respiration.",
"EPR characterization of the new Qrc complex from sulfate reducing bacteria and its ability to form a supercomplex with hydrogenase and TpIc3."
] | [
2010,
2011
] | 2 | [
"IPR050954"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati",
"hydrocarbon metagenome"
] | [
112,
1
] | 2 | [] | [] | 0 | true | Family | Menaquinone reductase iron-sulfur cluster-binding subunit | Menaquinone reductase iron-sulfur cluster-binding subunit | QrcC | 1 |
IPR053553 | 53,553 | Glucosyl-dolichyl phosphate glucuronosyltransferase | GDP_glucuronosyltransferase | Family | 245 | true | false | This family of proteins is involved in the N-glycosylation pathway, which is essential for the proper folding and function of many proteins. Members of this family function as enzymes that catalyze the addition of a glucuronate residue to a glucose residue already linked to dolichol phosphate. Dolichol phosphate acts a... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041394"
] | [
"GDP_glucuronosyltransferase"
] | [
245
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106322",
"PUB00106372"
] | [
"18631242",
"28809486"
] | [
"AglF, aglG and aglI, novel members of a gene island involved in the N-glycosylation of the Haloferax volcanii S-layer glycoprotein.",
"Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate."
] | [
2008,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
245
] | 1 | [] | [] | 0 | true | Family | Glucosyl-dolichyl phosphate glucuronosyltransferase | Glucosyl-dolichyl phosphate glucuronosyltransferase | GDP_glucuronosyltransferase | 4 |
IPR053554 | 53,554 | Glyceraldehyde dehydrogenase-related | Glyceraldehyde_dh-related | Family | 161 | true | false | This family of proteins includes enzymes that participate in the nonphosphorylated Entner-Doudoroff pathway. They are responsible for the oxidation of D-glyceraldehyde to produce glycerate. These enzymes exhibit a broad substrate range when using artificial electron acceptors, such as 2,6-dichlorophenol-indophenol, and... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041018"
] | [
"Glyceraldehyde_dh-related"
] | [
161
] | 1 | [] | [] | [] | 0 | [
"4zoh"
] | 1 | [
"PUB00106134"
] | [
"10095793"
] | [
"The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme--an aldehyde oxidoreductase."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thermoproteati"
] | [
6,
155
] | 2 | [] | [] | 0 | true | Family | Glyceraldehyde dehydrogenase-related | Glyceraldehyde dehydrogenase-related | Glyceraldehyde_dh-related | 5 |
IPR053555 | 53,555 | Type II topoisomerase GyrA/ParC | Topoisomerase_II_GyrA/ParC | Family | 204 | true | false | This family of proteins includes type II topoisomerases, specifically the GyrA/ParC subunit, which are essential enzymes that modify the topology of double-stranded DNA. These proteins are involved in introducing negative supercoils into DNA, which is crucial for various cellular processes such as replication, transcri... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038098"
] | [
"Topoisomerase_II_GyrA/ParC"
] | [
204
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
204
] | 1 | [] | [] | 0 | true | Family | Type II topoisomerase GyrA/ParC | Type II topoisomerase GyrA/ParC | Topoisomerase_II_GyrA/ParC | 4 |
IPR053556 | 53,556 | Glycosyl hydrolase 13 alpha-amylase | GH13_alpha-amylase | Family | 162 | true | false | This family of proteins includes alpha-amylases that are involved in the initial stages of starch degradation. They function as endo-acting enzymes, preferentially hydrolyzing linear polysaccharides over branched ones by cleaving alpha-1,4 glucosidic bonds. Members of this family exhibit transglycosylation activity and... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041321"
] | [
"GH13_alpha-amylase"
] | [
162
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106329"
] | [
"23391916"
] | [
"Gene analysis, expression, and characterization of an intracellular α-amylase from the extremely halophilic archaeon Haloarcula japonica."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
162
] | 1 | [] | [] | 0 | true | Family | Glycosyl hydrolase 13 alpha-amylase | Glycosyl hydrolase 13 alpha-amylase | GH13_alpha-amylase | 7 |
IPR053557 | 53,557 | Molybdopterin-binding Qrc complex component | Molybdopterin-Qrc_component | Family | 99 | true | false | This family of proteins includes components of the respiratory Qrc complex, which is involved in the reduction of the menaquinone pool using electrons from reduced periplasmic cytochrome c3. These proteins are likely crucial for growth on H(2) or formate as they interact with periplasmic hydrogenases and/or formate deh... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041783"
] | [
"Molybdopterin-Qrc_component"
] | [
99
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088946",
"PUB00152939"
] | [
"20498375",
"21651911"
] | [
"The Qrc membrane complex, related to the alternative complex III, is a menaquinone reductase involved in sulfate respiration.",
"EPR characterization of the new Qrc complex from sulfate reducing bacteria and its ability to form a supercomplex with hydrogenase and TpIc3."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Thermodesulfobacteriota",
"hydrocarbon metagenome"
] | [
98,
1
] | 2 | [] | [] | 0 | true | Family | Molybdopterin-binding Qrc complex component | Molybdopterin-binding Qrc complex component | Molybdopterin-Qrc_component | 3 |
IPR053558 | 53,558 | Type IV secretion system Dot/Icm subcomplex protein | T4SS_Dot/Icm_subcomplex | Family | 110 | true | false | This family of proteins is involved in a type IVB secretion system (T4BSS), specifically the Dot/Icm system, which is essential for the delivery of bacterial effector proteins into host eukaryotic cells. Members of this family form part of a subcomplex that is responsible for the recruitment and delivery of these effec... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038221"
] | [
"T4SS_Dot/Icm_subcomplex"
] | [
110
] | 1 | [] | [] | [] | 0 | [
"5x1h",
"5x42",
"6sz9",
"7ovb"
] | 4 | [
"PUB00105623"
] | [
"15652976"
] | [
"The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
110
] | 1 | [] | [] | 0 | true | Family | Type IV secretion system Dot/Icm subcomplex protein | Type IV secretion system Dot/Icm subcomplex protein | T4SS_Dot/Icm_subcomplex | 1 |
IPR053560 | 53,560 | Hyi sugar epimerase/isomerase | Hyi_epimerase/isomerase | Family | 46 | true | false | This family of proteins includes enzymes that are involved in the reversible epimerization of various sugars, playing a role in myo-inositol degradation pathways. They are capable of catalyzing the C3-epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D-psicose to D-fructose, and D-tagatose to D-sorbo... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041099"
] | [
"Hyi_epimerase/isomerase"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"2zvr",
"5b7y",
"5b7z",
"5b80",
"5h1w",
"5h6h"
] | 6 | [
"PUB00086033",
"PUB00153525"
] | [
"23441918",
"28258150"
] | [
"Novel inositol catabolic pathway in Thermotoga maritima.",
"TM0416, a Hyperthermophilic Promiscuous Nonphosphorylated Sugar Isomerase, Catalyzes Various C<sub>5</sub> and C<sub>6</sub> Epimerization Reactions."
] | [
2013,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
36,
10
] | 2 | [] | [] | 0 | true | Family | Hyi sugar epimerase/isomerase | Hyi sugar epimerase/isomerase | Hyi_epimerase/isomerase | 2 |
IPR053561 | 53,561 | UDP-N-acetylglucosamine 3-dehydrogenase | UDP-GlcNAc_3-dehydrogenase | Family | 113 | true | false | This family of proteins includes enzymes that are involved in the NAD(+)-dependent oxidation of UDP-N-acetylglucosamine (UDP-GlcNAc). They exhibit a high degree of substrate specificity, as they do not act on similar compounds such as UDP-glucose, UDP-N-acetylgalactosamine, N-acetylglucosamine, or glucosamine. The enzy... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040723"
] | [
"UDP-GlcNAc_3-dehydrogenase"
] | [
113
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105930"
] | [
"18634748"
] | [
"Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
113
] | 1 | [] | [] | 0 | true | Family | UDP-N-acetylglucosamine 3-dehydrogenase | UDP-N-acetylglucosamine 3-dehydrogenase | UDP-GlcNAc_3-dehydrogenase | 9 |
IPR053562 | 53,562 | 3-Hydroxyacyl-CoA Dehydrogenase-like | 3-Hydroxyacyl-CoA_DH-like | Family | 68 | true | false | This family of proteobacterial proteins includes 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase from Mesorhizobium japonicum, which is involved in the metabolic breakdown of vitamin B(6), specifically in the degradation pathway of pyridoxine. It catalyses the oxidation of a specific intermediate comp... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042925"
] | [
"3-Hydroxyacyl-CoA_DH-like"
] | [
68
] | 1 | [] | [] | [] | 0 | [
"4om8"
] | 1 | [
"PUB00153538",
"PUB00153539"
] | [
"19218190",
"25446130"
] | [
"Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase.",
"Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD⁺-dependent dismutase from Mesorhizobium loti."
] | [
2009,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria"
] | [
68
] | 1 | [] | [] | 0 | true | Family | 3-Hydroxyacyl-CoA Dehydrogenase-like | 3-Hydroxyacyl-CoA Dehydrogenase-like | 3-Hydroxyacyl-CoA_DH-like | 9 |
IPR053564 | 53,564 | Sensor kinase FixL-like | Sensor_kinase_FixL-like | Family | 118 | true | false | This family of proteins includes sensor proteins like FixL, which are involved in the regulation of kinase activity through a heme moiety. Members of this family function as putative oxygen sensors and play a role in modulating the activity of transcriptional activators involved in nitrogen fixation genes. They likely ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041777"
] | [
"Sensor_kinase_FixL-like"
] | [
118
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00024075",
"PUB00024282",
"PUB00139006"
] | [
"10926518",
"10747783",
"2046550"
] | [
"Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies.",
"New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL.",
"Involvement of fixLJ in the regulation of nitrogen fixa... | [
2000,
2000,
1991
] | 3 | [] | [] | 0 | 0 | null | [
"Hyphomicrobiales"
] | [
118
] | 1 | [] | [] | 0 | true | Family | Sensor kinase FixL-like | Sensor kinase FixL-like | Sensor_kinase_FixL-like | 1 |
IPR053565 | 53,565 | Glycosyl Hydrolase 78 | GH78 | Family | 153 | true | false | This family of proteins includes enzymes with alpha-L-rhamnosidase activity, capable of hydrolyzing alpha-L-rhamnopyranoside linkages. They play a role in the degradation of complex molecules, such as citrus flavonoids and arabinogalactan-proteins, releasing L-rhamnose. These enzymes are characterized by a carbohydrate... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041573"
] | [
"GH78"
] | [
153
] | 1 | [] | [] | [] | 0 | [
"3w5m",
"3w5n"
] | 2 | [
"PUB00065054"
] | [
"23291751"
] | [
"Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Streptomyces"
] | [
153
] | 1 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 78 | Glycosyl Hydrolase 78 | GH78 | 4 |
IPR053566 | 53,566 | 4'-Phosphopantetheinyl Transferase | P-Pant_transferase | Family | 161 | true | false | This family of proteins includes enzymes that are responsible for the post-translational modification of certain proteins by attaching a 4'-phosphopantetheine moiety from coenzyme A to a serine residue. This modification is crucial for converting apo-proteins to their active holo-forms, particularly in the activation o... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042923"
] | [
"P-Pant_transferase"
] | [
161
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095148"
] | [
"17102130"
] | [
"Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Nocardiaceae",
"freshwater metagenome"
] | [
160,
1
] | 2 | [] | [] | 0 | true | Family | 4'-Phosphopantetheinyl Transferase | 4'-Phosphopantetheinyl Transferase | P-Pant_transferase | 5 |
IPR053567 | 53,567 | Cytochrome c-550-like | Cytochrome_c-550-like | Family | 89 | true | false | This family of proteins is involved in the respiratory process of bacteria, particularly under oxygen-limited conditions. They are essential for the transfer of electrons during the process of denitrification, which is a part of the nitrogen cycle where nitrate is reduced and ultimately produces nitrogen gas under anae... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043008"
] | [
"Cytochrome_c-550-like"
] | [
89
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153628"
] | [
"7721713"
] | [
"Bradyrhizobium japonicum cytochrome c550 is required for nitrate respiration but not for symbiotic nitrogen fixation."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Nitrobacteraceae"
] | [
89
] | 1 | [] | [] | 0 | true | Family | Cytochrome c-550-like | Cytochrome c-550-like | Cytochrome_c-550-like | 6 |
IPR053568 | 53,568 | F(420)H(2) dehydrogenase complex subunit, archaea | F420H2_dehydrogenase_subunit | Family | 72 | true | true | This family of proteins is involved in the energy-conserving process of methylotrophic methanogens, particularly when they metabolize methanol or methylamines. Members of this family function as components of the F(420)H(2) dehydrogenase complex, which is crucial for the oxidation of methanophenazine to dihydromethanop... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040614"
] | [
"F420H2_dehydrogenase_subunit"
] | [
72
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994"
] | [
"10751389"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases."
] | [
2000
] | 1 | [
"IPR001133"
] | [] | 1 | 0 | 1 | [
"Methanobacteriati",
"hydrocarbon metagenome"
] | [
71,
1
] | 2 | [] | [] | 0 | true | Family | F(420)H(2) dehydrogenase complex subunit, archaea | F(420)H(2) dehydrogenase complex subunit, archaea | F420H2_dehydrogenase_subunit | 5 |
IPR053569 | 53,569 | Tungstate uptake ABC transporter ATPase | Tungstate_ABC_transporter | Family | 127 | true | false | This family of proteins is involved in the transport of tungstate across cellular membranes. Members of this family are part of an ABC transporter complex, which is characterized by its high affinity for tungstate, an oxyanion of tungsten. These proteins are likely to play a crucial role in the energy-dependent uptake ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041774"
] | [
"Tungstate_ABC_transporter"
] | [
127
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00113573"
] | [
"19818021"
] | [
"A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Campylobacter"
] | [
127
] | 1 | [] | [] | 0 | true | Family | Tungstate uptake ABC transporter ATPase | Tungstate uptake ABC transporter ATPase | Tungstate_ABC_transporter | 7 |
IPR053573 | 53,573 | Major Facilitator Superfamily Drug Efflux Pump | MFS_Drug_Efflux_Pump | Family | 147 | true | false | This family of proteins includes members that function as energy-dependent efflux pumps. They are involved in the active transport of various antimicrobial agents out of the cell, thereby contributing to increased resistance against certain drugs. These proteins are part of the major facilitator superfamily, which is c... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040895"
] | [
"MFS_Drug_Efflux_Pump"
] | [
147
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106050"
] | [
"16508166"
] | [
"Gene cloning and characterization of SdrM, a chromosomally-encoded multidrug efflux pump, from Staphylococcus aureus."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Staphylococcaceae",
"human gut metagenome"
] | [
146,
1
] | 2 | [] | [] | 0 | true | Family | Major Facilitator Superfamily Drug Efflux Pump | Major Facilitator Superfamily Drug Efflux Pump | MFS_Drug_Efflux_Pump | 3 |
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