interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR053574 | 53,574 | Cytoplasmic filament protein A | CfpA | Family | 57 | true | true | CfpA is a component of cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane [ ]. The full-length CfpA protein is localised to arrays of 4-6 filaments that lie in close apposition to the inner membrane. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040882"
] | [
"Cyto_Filament_Comp"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106040",
"PUB00106041",
"PUB00106042"
] | [
"10542176",
"16983193",
"8655496"
] | [
"Genetic and structural analyses of cytoplasmic filaments of wild-type Treponema phagedenis and a flagellar filament-deficient mutant.",
"Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family.",
"Characterization of the cytoplasmic filament protein gene ... | [
1999,
2006,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Potamilus streckersoni"
] | [
54,
3
] | 2 | [] | [] | 0 | true | Family | Cytoplasmic filament protein A | Cytoplasmic filament protein A | CfpA | 5 |
IPR053575 | 53,575 | Retron Ec78 HNH endonuclease | Retron_Ec78_HNH_endo | Family | 124 | true | false | This family of proteins includes putative HNH endonucleases that are part of an antiviral defense system known as retron Ec78. The system is composed of a non-coding RNA, a reverse transcriptase, a probable ATPase, and the HNH endonuclease. These proteins are implicated in providing protection against bacteriophage inf... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041761"
] | [
"Retron_Ec78_HNH_endo"
] | [
124
] | 1 | [] | [] | [] | 0 | [
"9kjx",
"9kjy",
"9kjz",
"9kk1",
"9kk2",
"9n69",
"9n6b",
"9nnb",
"9nnh",
"9nnk"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"hydrothermal vent metagenome"
] | [
122,
2
] | 2 | [] | [] | 0 | true | Family | Retron Ec78 HNH endonuclease | Retron Ec78 HNH endonuclease | Retron_Ec78_HNH_endo | 2 |
IPR053577 | 53,577 | Trans-sulfuration enzyme | Trans-sulfuration_enzyme | Family | 127 | true | false | This family of proteins includes enzymes that are involved in the trans-sulfuration pathway, which is crucial for the metabolism of sulfur-containing amino acids. Members of this family catalyze the cleavage of cystathionine to produce homocysteine, a reaction that is central to the conversion of methionine to cysteine... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043007"
] | [
"Trans-sulfuration_enzyme"
] | [
127
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153663"
] | [
"19035565"
] | [
"Properties of recombinant Staphylococcus haemolyticus cystathionine beta-lyase (metC) and its potential role in the generation of volatile thiols in axillary malodor."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Staphylococcaceae"
] | [
127
] | 1 | [] | [] | 0 | true | Family | Trans-sulfuration enzyme | Trans-sulfuration enzyme | Trans-sulfuration_enzyme | 7 |
IPR053578 | 53,578 | UDP-sulfoquinovose synthase | UDP-sulfoquinovose_synthase | Family | 90 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of UDP-sulfoquinovose, which is a crucial component for the assembly of the S-layer N-glycans in certain organisms. Members of this family function by transferring sulfite to UDP-glucose, a process that is likely facilitated by NAD(+)-depend... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041015"
] | [
"UDP-sulfoquinovose_synthase"
] | [
90
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106130",
"PUB00106131"
] | [
"22059775",
"25605538"
] | [
"Sulfoquinovose synthase - an important enzyme in the N-glycosylation pathway of Sulfolobus acidocaldarius.",
"UDP-sulfoquinovose formation by Sulfolobus acidocaldarius."
] | [
2011,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"mine drainage metagenome"
] | [
88,
2
] | 2 | [] | [] | 0 | true | Family | UDP-sulfoquinovose synthase | UDP-sulfoquinovose synthase | UDP-sulfoquinovose_synthase | 3 |
IPR053579 | 53,579 | 3-Hydroxypropionate/Butyrate CoA Ligase | 3HP/4HB_CoA_Ligase | Family | 45 | true | false | This family of proteins is involved in a modified autotrophic carbon fixation pathway known as the hydroxypropionate/hydroxybutyrate (HP/HB) cycle, which is characteristic of certain archaeal organisms. Members of this family function as enzymes that catalyze the ATP-dependent ligation of CoA to various organic acids, ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045492"
] | [
"3HP/4HB_CoA_Ligase"
] | [
45
] | 1 | [] | [] | [] | 0 | [
"9y43"
] | 1 | [
"PUB00153658"
] | [
"24843170"
] | [
"Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Geodia barretti",
"Nitrososphaerota"
] | [
1,
44
] | 2 | [] | [] | 0 | true | Family | 3-Hydroxypropionate/Butyrate CoA Ligase | 3-Hydroxypropionate/Butyrate CoA Ligase | 3HP/4HB_CoA_Ligase | 2 |
IPR053580 | 53,580 | 4-hydroxybutyrate--CoA ligase [ADP-forming] | 4-HB-CoA_ligase_ADP-forming | Family | 45 | true | false | This family of proteins is involved in a modified autotrophic hydroxypropionate/hydroxybutyrate cycle, which is central to the metabolism of certain archaeal organisms. Members of this family are enzymes that catalyze the ATP-dependent ligation of 4-hydroxybutyrate with coenzyme A to form 4-hydroxybutyryl-CoA, releasin... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045493"
] | [
"4-HB-CoA_ligase_ADP-forming"
] | [
45
] | 1 | [] | [] | [] | 0 | [
"8wzu"
] | 1 | [
"PUB00153658"
] | [
"24843170"
] | [
"Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Nitrososphaerota"
] | [
45
] | 1 | [] | [] | 0 | true | Family | 4-hydroxybutyrate--CoA ligase [ADP-forming] | 4-hydroxybutyrate--CoA ligase [ADP-forming] | 4-HB-CoA_ligase_ADP-forming | 5 |
IPR053581 | 53,581 | 4'-Phosphopantetheinyl Transferase HetI-like | P-Pant_Transferase_HetI-like | Family | 98 | true | false | This family of proteins is involved in the activation of acyl carrier protein (ACP) domains within certain biosynthetic enzymes. Members of this family are responsible for the post-translational modification of ACP domains by transferring the 4'-phosphopantetheinyl moiety from coenzyme A to a serine residue on the ACP.... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042922"
] | [
"P-Pant_Transferase_HetI-like"
] | [
98
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019094",
"PUB00153620"
] | [
"8939709",
"8157596"
] | [
"A new enzyme superfamily - the phosphopantetheinyl transferases.",
"Analysis of a Het- mutation in Anabaena sp. strain PCC 7120 implicates a secondary metabolite in the regulation of heterocyst spacing."
] | [
1996,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Cyanophyceae"
] | [
98
] | 1 | [] | [] | 0 | true | Family | 4'-Phosphopantetheinyl Transferase HetI-like | 4'-Phosphopantetheinyl Transferase HetI-like | P-Pant_Transferase_HetI-like | 7 |
IPR053582 | 53,582 | Homoaconitase small subunit LeuD type 2 | Homoaconitase_LeuD_type2 | Family | 59 | true | false | This family of proteins includes hydro-lyases with a broad substrate specificity, acting on cis-unsaturated tricarboxylic acids. They are capable of catalyzing the reversible dehydration of (R)-homocitrate to cis-homoaconitate, as well as the hydration of cis-homoaconitate to homoisocitrate. Additionally, they can hydr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040625"
] | [
"Homoaconitase_LeuD_type2"
] | [
59
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054348"
] | [
"20170198"
] | [
"Substrate specificity determinants of the methanogen homoaconitase enzyme: structure and function of the small subunit."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"bioreactor metagenome"
] | [
58,
1
] | 2 | [] | [] | 0 | true | Family | Homoaconitase small subunit LeuD type 2 | Homoaconitase small subunit LeuD type 2 | Homoaconitase_LeuD_type2 | 8 |
IPR053583 | 53,583 | ROK family beta-glucoside kinase | ROK_beta-glucoside_kinase | Family | 107 | true | false | This family of proteins is involved in the ATP-dependent phosphorylation of various beta-D-glucosides, resulting in the formation of 6-phospho-beta-D-glucosides. Members of this family are capable of processing substrates such as cellobiose, gentiobiose, cellobiitol, salicin, and arbutin, but they do not act on alpha-D... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042998"
] | [
"ROK_beta-glucoside_kinase"
] | [
107
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153656"
] | [
"12110692"
] | [
"Beta-glucoside kinase (BglK) from Klebsiella pneumoniae. Purification, properties, and preparative synthesis of 6-phospho-beta-D-glucosides."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
107
] | 1 | [] | [] | 0 | true | Family | ROK family beta-glucoside kinase | ROK family beta-glucoside kinase | ROK_beta-glucoside_kinase | 1 |
IPR053584 | 53,584 | RecJ exonuclease | RecJ_exonuclease | Family | 77 | true | false | This family of proteins includes single-stranded-DNA-specific exonucleases, which are enzymes that catalyze the removal of nucleotides from the ends of single-stranded DNA (ssDNA). These proteins play a crucial role in DNA repair and maintenance by processing ssDNA regions that can arise during DNA replication, recombi... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040701"
] | [
"RecJ_exonuclease"
] | [
77
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007151"
] | [
"10633092"
] | [
"A thermostable single-strand DNase from Methanococcus jannaschii related to the RecJ recombination and repair exonuclease from Escherichia coli."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Methanomada group",
"bioreactor metagenome"
] | [
76,
1
] | 2 | [] | [] | 0 | true | Family | RecJ exonuclease | RecJ exonuclease | RecJ_exonuclease | 7 |
IPR053585 | 53,585 | 3-beta-Hydroxysteroid Dehydrogenase-like | 3-beta-HSD-like | Family | 112 | true | false | This family of proteins is involved in the biosynthesis of olefins, a class of hydrocarbons. Members of this family function as enzymes that catalyze the NADPH-dependent reduction of 2-alkyl-3-oxoalkanoic acids to their corresponding 2-alkyl-3-hydroxyalkanoic acids. This reaction is reversible and stereospecific. The e... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042423"
] | [
"3-beta-HSD-like"
] | [
112
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153446"
] | [
"20418444"
] | [
"Structure, function, and insights into the biosynthesis of a head-to-head hydrocarbon in Shewanella oneidensis strain MR-1."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
112
] | 1 | [] | [] | 0 | true | Family | 3-beta-Hydroxysteroid Dehydrogenase-like | 3-beta-Hydroxysteroid Dehydrogenase-like | 3-beta-HSD-like | 5 |
IPR053586 | 53,586 | Glyceraldehyde dehydrogenase medium chain | Glyceraldehyde_DH_medium | Family | 100 | true | false | This family of proteins includes enzymes that participate in the nonphosphorylated Entner-Doudoroff pathway. They are responsible for the oxidation of D-glyceraldehyde, producing glycerate. These enzymes exhibit a broad substrate specificity when artificial electron acceptors are used, capable of oxidizing various alde... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041019"
] | [
"Glyceraldehyde_DH_medium"
] | [
100
] | 1 | [] | [] | [] | 0 | [
"4zoh"
] | 1 | [
"PUB00106134"
] | [
"10095793"
] | [
"The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme--an aldehyde oxidoreductase."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoflexibacter ruber",
"Thermoprotei"
] | [
1,
99
] | 2 | [] | [] | 0 | true | Family | Glyceraldehyde dehydrogenase medium chain | Glyceraldehyde dehydrogenase medium chain | Glyceraldehyde_DH_medium | 6 |
IPR053587 | 53,587 | Bacterial phytochrome-like | Bacterial_phytochrome-like | Family | 109 | true | false | This family of proteins functions as photoreceptors that can exist in two different light-responsive forms. The red-absorbing form (Pr) is induced by far-red light, while the far-red-absorbing form (Pfr) is favored in the dark or under red light. These proteins are involved in regulating virulence in certain bacteria, ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041576"
] | [
"Bacterial_phytochrome-like"
] | [
109
] | 1 | [] | [] | [] | 0 | [
"5akp",
"5uyr",
"6ndo",
"6ndp",
"6pl0",
"7l59",
"7l5a"
] | 7 | [
"PUB00151389",
"PUB00151390"
] | [
"27621284",
"27107635"
] | [
"Xanthomonas campestris attenuates virulence by sensing light through a bacteriophytochrome photoreceptor.",
"Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism."
] | [
2016,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Lysobacteraceae"
] | [
109
] | 1 | [] | [] | 0 | true | Family | Bacterial phytochrome-like | Bacterial phytochrome-like | Bacterial_phytochrome-like | 3 |
IPR053588 | 53,588 | Chemotaxis signal transducer CheA | CheA_signal_transducer | Family | 100 | true | false | This family of proteins plays a crucial role in bacterial chemotaxis, the movement towards or away from chemical stimuli. Members of this family are responsible for processing signals from sensory receptors, which can be either chemoreceptors or photoreceptors. Upon receiving a signal, these proteins undergo autophosph... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041336"
] | [
"CheA_signal_transducer"
] | [
100
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106340",
"PUB00106341"
] | [
"23171228",
"7882970"
] | [
"The protein interaction network of a taxis signal transduction system in a halophilic archaeon.",
"Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium."
] | [
2012,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
100
] | 1 | [] | [] | 0 | true | Family | Chemotaxis signal transducer CheA | Chemotaxis signal transducer CheA | CheA_signal_transducer | 2 |
IPR053589 | 53,589 | Betaine reductase complex component B subunit beta | Betaine_reductase_B_beta | Family | 88 | true | false | This family of proteins is involved in the reductive deamination process, where the substrate is initially bound to a component via a Schiff base intermediate. A selenol anion then nucleophilically attacks the activated substrate, leading to the formation of a carboxymethylated selenoether and the release of the respec... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040795"
] | [
"Betaine_reductase_B_beta"
] | [
88
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019650",
"PUB00105968"
] | [
"8529639",
"20937090"
] | [
"Purification and characterization of protein PB of betaine reductase and its relationship to the corresponding proteins glycine reductase and sarcosine reductase from Eubacterium acidaminophilum.",
"Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome seque... | [
1995,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
88
] | 1 | [] | [] | 0 | true | Family | Betaine reductase complex component B subunit beta | Betaine reductase complex component B subunit beta | Betaine_reductase_B_beta | 8 |
IPR053590 | 53,590 | Glyceraldehyde dehydrogenase small chain-like | Glyceraldehyde_DH_small | Family | 92 | true | false | This family of proteins includes enzymes that participate in the nonphosphorylated Entner-Doudoroff pathway, a metabolic route distinct from glycolysis. Members of this family are responsible for the oxidation of D-glyceraldehyde, producing glycerate. These enzymes exhibit a broad substrate specificity in the presence ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041020"
] | [
"Glyceraldehyde_DH_small"
] | [
92
] | 1 | [] | [] | [] | 0 | [
"4zoh"
] | 1 | [
"PUB00106134"
] | [
"10095793"
] | [
"The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme--an aldehyde oxidoreductase."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoproteati"
] | [
92
] | 1 | [] | [] | 0 | true | Family | Glyceraldehyde dehydrogenase small chain-like | Glyceraldehyde dehydrogenase small chain-like | Glyceraldehyde_DH_small | 3 |
IPR053591 | 53,591 | Cytochrome c | Cytochrome_c | Family | 83 | true | false | This family of proteins is typically involved in electron transport processes. Members of this family are known to participate in redox reactions, which are crucial for various biological energy conversion pathways. Specifically, they may play a role in anaerobic respiration mechanisms, such as iron respiration, where ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043011"
] | [
"Cytochrome_c"
] | [
83
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094333"
] | [
"10386369"
] | [
"Purification and characterization of triheme cytochrome c7 from the metal-reducing bacterium, Geobacter metallireducens."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Desulfuromonadia"
] | [
83
] | 1 | [] | [] | 0 | true | Family | Cytochrome c | Cytochrome c | Cytochrome_c | 1 |
IPR053592 | 53,592 | Flagella basal body rod | Flagellar_basal_body_rod | Family | 56 | true | false | This family of proteins is involved in the formation of the bacterial flagellum, which is a complex structure responsible for motility in many bacteria. Members of this family are typically components of the basal body rod, a crucial part of the flagellar apparatus that provides a scaffold for the flagellum and is esse... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040922"
] | [
"Flagellar_basal_body_rod"
] | [
56
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106063",
"PUB00106064"
] | [
"11405627",
"27759043"
] | [
"Organization, expression, and function of Caulobacter crescentus genes needed for assembly and function of the flagellar hook.",
"Structural insights into bacterial flagellar hooks similarities and specificities."
] | [
2001,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Caulobacteraceae"
] | [
56
] | 1 | [] | [] | 0 | true | Family | Flagella basal body rod | Flagella basal body rod | Flagellar_basal_body_rod | 1 |
IPR053593 | 53,593 | FAD-dependent oxidoreductase 2/FRD/SDH | FAD-oxidoreductase_2/FRD/SDH | Family | 83 | true | false | This family of proteins includes flavoprotein subunits that are part of the 8-methylmenaquinol:fumarate reductase complex, which is involved in anaerobic metabolism. These proteins are responsible for the enzymatic reduction of fumarate to succinate, using 8-methylmenaquinol-6 as the electron donor. The family members ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042982"
] | [
"FAD-oxidoreductase_2/FRD/SDH"
] | [
83
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153521"
] | [
"19170876"
] | [
"Production, characterization and determination of the real catalytic properties of the putative 'succinate dehydrogenase' from Wolinella succinogenes."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"bioreactor metagenome"
] | [
82,
1
] | 2 | [] | [] | 0 | true | Family | FAD-dependent oxidoreductase 2/FRD/SDH | FAD-dependent oxidoreductase 2/FRD/SDH | FAD-oxidoreductase_2/FRD/SDH | 5 |
IPR053594 | 53,594 | Sarcosine Reductase Complex Component | Sarcosine_Reductase_Comp | Family | 79 | true | false | This family of proteins is involved in the reductive deamination of sarcosine. The proteins function as components of a sarcosine reductase complex, which catalyzes the transformation of sarcosine into a carboxymethylated selenoether and the respective amine. This process involves the formation of a Schiff base interme... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040793"
] | [
"Sarcosine_Reductase_Comp"
] | [
79
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105967"
] | [
"24926057"
] | [
"Complete Genome Sequence of Amino Acid-Utilizing Eubacterium acidaminophilum al-2 (DSM 3953)."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
79
] | 1 | [] | [] | 0 | true | Family | Sarcosine Reductase Complex Component | Sarcosine Reductase Complex Component | Sarcosine_Reductase_Comp | 1 |
IPR053595 | 53,595 | Cytochrome b-type electron transport | Cytochrome_b-type_ET | Family | 85 | true | false | This family of proteins includes members that are involved in electron transport by binding to heme groups. Each protein within this family can bind two distinct heme groups, which are integral to the protein's function but are not covalently attached. These heme groups play a critical role in the protein's ability to ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041076"
] | [
"Cytochrome_b-type_ET"
] | [
85
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106158",
"PUB00106159",
"PUB00106160"
] | [
"1372250",
"7984110",
"9079667"
] | [
"An archaebacterial terminal oxidase combines core structures of two mitochondrial respiratory complexes.",
"The purified SoxABCD quinol oxidase complex of Sulfolobus acidocaldarius contains a novel haem.",
"The archaeal SoxABCD complex is a proton pump in Sulfolobus acidocaldarius."
] | [
1992,
1994,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
85
] | 1 | [] | [] | 0 | true | Family | Cytochrome b-type electron transport | Cytochrome b-type electron transport | Cytochrome_b-type_ET | 5 |
IPR053596 | 53,596 | Cytochrome c-554-like | Cytochrome_c-554-like | Family | 41 | true | false | This family of proteins is involved in the biological process of ammonia oxidation. Members of this family are capable of accepting electrons from the enzyme hydroxylamine oxidoreductase, which is a key step in the conversion of ammonia to nitrite. This electron transfer is essential for the energy metabolism of organi... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043010"
] | [
"Cytochrome_c-554-like"
] | [
41
] | 1 | [] | [] | [] | 0 | [
"1bvb",
"1ft5",
"1ft6"
] | 3 | [
"PUB00025023",
"PUB00153544",
"PUB00153545"
] | [
"11372197",
"8063110",
"8195067"
] | [
"High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea.",
"Sequence of hcy, a gene encoding cytochrome c-554 from Nitrosomonas europaea.",
"Organization of the hao gene cluster of Nitrosomonas europaea: genes for two tetraheme c cytochromes."
] | [
2001,
1994,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
41
] | 1 | [] | [] | 0 | true | Family | Cytochrome c-554-like | Cytochrome c-554-like | Cytochrome_c-554-like | 1 |
IPR053597 | 53,597 | Retron Ec48 transmembrane protein | Retron_Ec48 | Family | 84 | true | true | This family of proteins includes membrane components of the Retron Ec48 antiviral defense system. These proteins are associated with a non-coding RNA and a reverse transcriptase to form a complex that protects bacteria against various bacteriophages. The N-terminal transmembrane region of these proteins is essential fo... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF038235",
"PF28197"
] | [
"Retron_Ec48_antiviral",
"Retron_Ec48_antiviral"
] | [
83,
67
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00101106"
] | [
"33157039"
] | [
"Bacterial Retrons Function In Anti-Phage Defense."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Escherichia phage pro147",
"Pseudomonadota",
"ecological metagenomes"
] | [
1,
80,
3
] | 3 | [] | [] | 0 | true | Family | Retron Ec48 transmembrane protein | Retron Ec48 transmembrane protein | Retron_Ec48 | 2 |
IPR053598 | 53,598 | ABC transporter glucose import ATPase | ABC-Glucose_import_ATPase | Family | 58 | true | false | This family of proteins is involved in the active transport of glucose across the cell membrane. Members function as part of an ABC transporter complex, which typically includes additional components for substrate specificity and translocation. These proteins utilize the energy derived from ATP hydrolysis to drive the ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040933"
] | [
"ABC-Glucose_import_ATPase"
] | [
58
] | 1 | [] | [] | [] | 0 | [
"1oxs",
"1oxt",
"1oxu",
"1oxv",
"1oxx"
] | 5 | [
"PUB00013790",
"PUB00106073"
] | [
"11260467",
"10400586"
] | [
"Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters.",
"Glucose transport in the extremely thermoacidophilic Sulfolobus solfataricus involves a high-affinity membrane-integrated binding protein."
] | [
2001,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
58
] | 1 | [] | [] | 0 | true | Family | ABC transporter glucose import ATPase | ABC transporter glucose import ATPase | ABC-Glucose_import_ATPase | 5 |
IPR053599 | 53,599 | Alkane Uptake OmpP1/FadL-like Protein | Alkane_Uptake_OmpP1/FadL | Family | 59 | true | false | This family of proteins is implicated in the process of alkane utilization, playing a crucial role in the growth of organisms on alkanes. Members are likely involved in the transport of alkanes into the cell, facilitating their uptake by interacting with micelle-solubilized alkanes. The family is characterized by its s... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041571"
] | [
"Alkane_Uptake_OmpP1/FadL"
] | [
59
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151384"
] | [
"29871914"
] | [
"AupA and AupB Are Outer and Inner Membrane Proteins Involved in Alkane Uptake in Marinobacter hydrocarbonoclasticus SP17."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Marinobacter"
] | [
59
] | 1 | [] | [] | 0 | true | Family | Alkane Uptake OmpP1/FadL-like Protein | Alkane Uptake OmpP1/FadL-like Protein | Alkane_Uptake_OmpP1/FadL | 5 |
IPR053600 | 53,600 | Protein-lysine N-methyltransferase | Lysine_N-MTase | Family | 62 | true | false | This family of proteins includes enzymes that function as protein-lysine N-methyltransferases. They are involved in the post-translational modification of lysine residues in target proteins by transferring methyl groups from S-adenosyl-L-methionine (SAM) to the amino group of lysine side chains. These modifications can... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041081"
] | [
"Lysine_N-MTase"
] | [
62
] | 1 | [] | [] | [] | 0 | [
"5fa8",
"5fad",
"5jwj"
] | 3 | [
"PUB00106163"
] | [
"23086207"
] | [
"Identification and characterization of a highly conserved crenarchaeal protein lysine methyltransferase with broad substrate specificity."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
62
] | 1 | [] | [] | 0 | true | Family | Protein-lysine N-methyltransferase | Protein-lysine N-methyltransferase | Lysine_N-MTase | 2 |
IPR053602 | 53,602 | Mandelate racemase/muconate lactonizing enzyme-like | MR_MLE-like | Family | 56 | true | false | This family of proteins is involved in the epimerization of specific dipeptides, which is a type of isomerization where the stereochemistry of an amino acid within a peptide is altered. Members of this family are capable of catalyzing the conversion of L-Ala-D-Glu to L-Ala-L-Glu, a reaction that is likely important in ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041118"
] | [
"MR_MLE-like"
] | [
56
] | 1 | [] | [] | [] | 0 | [
"2zad",
"3deq",
"3der",
"3des",
"3dfy"
] | 5 | [
"PUB00051364"
] | [
"19000819"
] | [
"Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
56
] | 1 | [] | [] | 0 | true | Family | Mandelate racemase/muconate lactonizing enzyme-like | Mandelate racemase/muconate lactonizing enzyme-like | MR_MLE-like | 6 |
IPR053603 | 53,603 | CRISPR-associated Cas12b endonuclease | Cas12b_endonuclease | Family | 25 | true | false | This family of proteins is involved in the CRISPR adaptive immune system, which provides defense against mobile genetic elements such as viruses and plasmids. Members of this family function as endonucleases that cleave double-stranded DNA complementary to CRISPR RNA (crRNA) sequences. These proteins require a crRNA, w... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033949"
] | [
"Cas12b_endonuclease"
] | [
25
] | 1 | [] | [] | [] | 0 | [
"5u30",
"5u31",
"5u33",
"5u34",
"5wqe",
"5wti",
"9kln",
"9klo",
"9klp",
"9klq"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
25
] | 1 | [] | [] | 0 | true | Family | CRISPR-associated Cas12b endonuclease | CRISPR-associated Cas12b endonuclease | Cas12b_endonuclease | 2 |
IPR053604 | 53,604 | F(420)H(2) dehydrogenase complex subunit I | F420H2_dehydrogenase_I | Family | 57 | true | false | This family of proteins is involved in the energy-conserving processes of methylotrophic methanogens, particularly during growth on methanol or methylamines. Members of this family are components of the F(420)H(2) dehydrogenase complex, which is crucial for the oxidation of methanophenazine to dihydromethanophenazine. ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040612"
] | [
"F420H2_dehydrogenase_I"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994"
] | [
"10751389"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae"
] | [
57
] | 1 | [] | [] | 0 | true | Family | F(420)H(2) dehydrogenase complex subunit I | F(420)H(2) dehydrogenase complex subunit I | F420H2_dehydrogenase_I | 6 |
IPR053605 | 53,605 | Lignin-Degrading GST-like Enzyme | Lignin-Degrading_GST-like | Family | 52 | true | false | This family of proteins includes enzymes that are capable of degrading lignin-derived compounds. Specifically, they perform a reductive cleavage of arylglycerol-beta-aryl ether linkages, which are prevalent in lignin. These enzymes are part of the glutathione S-transferase (GST) superfamily, which is known for its role... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042997"
] | [
"Lignin-Degrading_GST-like"
] | [
52
] | 1 | [] | [] | [] | 0 | [
"4yam",
"4yan"
] | 2 | [
"PUB00116077",
"PUB00116079",
"PUB00153616"
] | [
"8495726",
"1744051",
"26637355"
] | [
"A bacterial enzyme degrading the model lignin compound beta-etherase is a member of the glutathione-S-transferase superfamily.",
"Cloning and sequencing of the gene for a Pseudomonas paucimobilis enzyme that cleaves beta-aryl ether.",
"Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage o... | [
1993,
1991,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria"
] | [
52
] | 1 | [] | [] | 0 | true | Family | Lignin-Degrading GST-like Enzyme | Lignin-Degrading GST-like Enzyme | Lignin-Degrading_GST-like | 2 |
IPR053606 | 53,606 | Complex I 30 kDa subunit-like | Complex_I_30kDa_subunit-like | Family | 55 | true | false | This family of proteins includes components of the F(420)H(2) dehydrogenase complex, which is integral to the energy-conserving systems in methylotrophic methanogens. These proteins are involved in the oxidation of reduced coenzyme F(420)H(2), transferring electrons through FAD and iron-sulfur centers to methanophenazi... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040611"
] | [
"Complex_I_30kDa_subunit-like"
] | [
55
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994"
] | [
"10751389"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae"
] | [
55
] | 1 | [] | [] | 0 | true | Family | Complex I 30 kDa subunit-like | Complex I 30 kDa subunit-like | Complex_I_30kDa_subunit-like | 6 |
IPR053607 | 53,607 | Complex I subunit 6-like | Complex_I_subunit_6-like | Family | 54 | true | false | This family of proteins includes components of the F(420)H(2) dehydrogenase complex, which is crucial for the energy metabolism in certain methanogenic archaea. These proteins are involved in the oxidation of reduced coenzyme F(420)H(2) and transfer electrons to methanophenazine, a membrane electron carrier. They conta... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040613"
] | [
"Complex_I_subunit_6-like"
] | [
54
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994"
] | [
"10751389"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae"
] | [
54
] | 1 | [] | [] | 0 | true | Family | Complex I subunit 6-like | Complex I subunit 6-like | Complex_I_subunit_6-like | 8 |
IPR053608 | 53,608 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit | SDH/FR_iron-sulfur_subunit | Family | 61 | true | false | This family of proteins includes iron-sulfur subunits of enzymes like 8-methylmenaquinol:fumarate reductase (MFR), which are involved in the anaerobic metabolism. These proteins catalyze the reduction of fumarate to succinate, using electron donors such as 8-methylmenaquinol-6. Despite being related to succinate dehydr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042952"
] | [
"SDH/FR_iron-sulfur_subunit"
] | [
61
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153521"
] | [
"19170876"
] | [
"Production, characterization and determination of the real catalytic properties of the putative 'succinate dehydrogenase' from Wolinella succinogenes."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
61
] | 1 | [] | [] | 0 | true | Family | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit | SDH/FR_iron-sulfur_subunit | 3 |
IPR053609 | 53,609 | Sensor Histidine Kinase MalK-like | Histidine_kinase_MalK-like | Family | 67 | true | false | This family of proteins includes sensor histidine kinases like MalK, which are part of two-component regulatory systems. They are involved in the response to specific environmental stimuli, such as the presence of malate. These proteins typically function by activating response regulators, such as MalR, through phospho... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF038334"
] | [
"Histidine_kinase_MalK-like"
] | [
67
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus"
] | [
67
] | 1 | [] | [] | 0 | true | Family | Sensor Histidine Kinase MalK-like | Sensor Histidine Kinase MalK-like | Histidine_kinase_MalK-like | 7 |
IPR053610 | 53,610 | F(420)H(2) dehydrogenase complex component | F420H2_dehydrogenase_comp | Family | 54 | true | false | This family of proteins includes components of the F(420)H(2) dehydrogenase complex, which is crucial for the energy metabolism in certain methanogenic archaea. Members are involved in the oxidation of reduced coenzyme F(420)H(2) to its oxidized form, transferring electrons to methanophenazine or other quinones. This p... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040617"
] | [
"F420H2_dehydrogenase_comp"
] | [
54
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994"
] | [
"10751389"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae"
] | [
54
] | 1 | [] | [] | 0 | true | Family | F(420)H(2) dehydrogenase complex component | F(420)H(2) dehydrogenase complex component | F420H2_dehydrogenase_comp | 5 |
IPR053611 | 53,611 | Glycogen_Phosphorylase | Glycogen_Phosphorylase | Family | 43 | true | false | This family of proteins includes allosteric enzymes involved in carbohydrate metabolism. Members catalyze the phospholytic cleavage of maltodextrins to produce glucose-1-phosphate. They exhibit a preference for maltodextrins with a minimum of five glucose residues, while showing lower activity with shorter chains and n... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041129"
] | [
"Glycogen_Phosphorylase"
] | [
43
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106188"
] | [
"10348846"
] | [
"Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: purification and characterization of key enzymes."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thermococcaceae"
] | [
4,
39
] | 2 | [] | [] | 0 | true | Family | Glycogen_Phosphorylase | Glycogen_Phosphorylase | Glycogen_Phosphorylase | 1 |
IPR053613 | 53,613 | Aliphatic Nitrilase | Aliphatic_Nitrilase | Family | 42 | true | false | This family of proteins includes enzymes that exhibit nitrilase activity, catalyzing the hydrolysis of aliphatic nitriles into corresponding monoacid mononitriles. They are regioselective, preferring substrates such as malononitrile and fumaronitrile, and do not act on nitriles bound to aromatic rings or amino acids. T... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040852"
] | [
"Aliphatic_Nitrilase"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"1j31",
"3ivz",
"3iw3",
"3ki8",
"3klc",
"6ypa",
"7ovg"
] | 7 | [
"PUB00055161",
"PUB00106023"
] | [
"21095228",
"16495079"
] | [
"Crystallographic analysis of a thermoactive nitrilase.",
"Cloning, overexpression, and characterization of a thermoactive nitrilase from the hyperthermophilic archaeon Pyrococcus abyssi."
] | [
2011,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Aliphatic Nitrilase | Aliphatic Nitrilase | Aliphatic_Nitrilase | 9 |
IPR053614 | 53,614 | SMC SbcC-like nuclease | SMC_SbcC-like_nuclease | Family | 63 | true | false | This family of proteins is involved in DNA repair and maintenance. Members of this family function to resolve DNA hairpin structures that can pose a barrier to DNA replication and recombination processes. They exhibit a 3'->5' double-strand exonuclease activity that enables them to unwind and cleave these hairpins. Add... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041752"
] | [
"SMC_SbcC-like_nuclease"
] | [
63
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091859",
"PUB00152912"
] | [
"16780573",
"19906728"
] | [
"Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair.",
"A novel SMC-like protein, SbcE (YhaN), is involved in DNA double-strand break repair and competence in Bacillus subtilis."
] | [
2006,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillus"
] | [
63
] | 1 | [] | [] | 0 | true | Family | SMC SbcC-like nuclease | SMC SbcC-like nuclease | SMC_SbcC-like_nuclease | 7 |
IPR053615 | 53,615 | PCNA-inhibitor | PCNA-inhibitor | Family | 41 | false | false | This family of proteins includes PCNA-inhibitors from archaea, which interact with the DNA polymerase sliding clamp, known as proliferating cell nuclear antigen (PCNA), and is involved in the regulation of DNA replication and repair processes. Members of this family are capable of binding to PCNA and disrupting its tri... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF041142",
"PF28198"
] | [
"PCNA_Inhib",
"PCNA-interact_regulator"
] | [
41,
41
] | 2 | [] | [] | [] | 0 | [
"5da7"
] | 1 | [
"PUB00106195",
"PUB00106196"
] | [
"24728986",
"27141962"
] | [
"A novel mechanism for regulating the activity of proliferating cell nuclear antigen by a small protein.",
"A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp."
] | [
2014,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
41
] | 1 | [] | [] | 0 | true | Family | PCNA-inhibitor | PCNA-inhibitor | PCNA-inhibitor | 7 |
IPR053616 | 53,616 | GHMP Kinase PoK-Type | GHMP_kinase_PoK-type | Family | 41 | true | false | This family of proteins is involved in the biosynthesis of coenzyme A (CoA), a fundamental molecule for various biochemical reactions. Members of this family catalyze the phosphorylation of (R)-pantoate, converting it into (R)-4-phosphopantoate, which is a critical step in the CoA biosynthesis pathway. These enzymes ex... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041122"
] | [
"GHMP_kinase_PoK-type"
] | [
41
] | 1 | [] | [] | [] | 0 | [
"6jbc",
"6jbd"
] | 2 | [
"PUB00060435",
"PUB00106183"
] | [
"19666462",
"22865846"
] | [
"Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.",
"Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea."
] | [
2009,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
41
] | 1 | [] | [] | 0 | true | Family | GHMP Kinase PoK-Type | GHMP Kinase PoK-Type | GHMP_kinase_PoK-type | 6 |
IPR053617 | 53,617 | Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase | GAPOR | Family | 42 | true | false | This family of proteins includes glycolytic enzymes that substitute for both glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in the glycolysis pathway. They are involved in anabolic gluconeogenesis, a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrate... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040818"
] | [
"GAPOR"
] | [
42
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007129",
"PUB00105990"
] | [
"7721730",
"9774434"
] | [
"Glyceraldehyde-3-phosphate ferredoxin oxidoreductase, a novel tungsten-containing enzyme with a potential glycolytic role in the hyperthermophilic archaeon Pyrococcus furiosus.",
"The ferredoxin-dependent conversion of glyceraldehyde-3-phosphate in the hyperthermophilic archaeon Pyrococcus furiosus represents a ... | [
1995,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase | Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase | GAPOR | 7 |
IPR053618 | 53,618 | tRNA N1-methyltransferase | tRNA_N1-methyltransferase | Family | 41 | true | false | This family of proteins includes enzymes that function as tRNA methyltransferases. Members of this family are responsible for the methylation of guanine(9) and adenine(9) at the N1 position in tRNA molecules. They utilize S-adenosyl-L-methionine as the methyl donor for this modification. The methylation of nucleotides ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041140"
] | [
"tRNA_N1-methyltransferase"
] | [
41
] | 1 | [] | [] | [] | 0 | [
"6ems"
] | 1 | [
"PUB00075405"
] | [
"20525789"
] | [
"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
41
] | 1 | [] | [] | 0 | true | Family | tRNA N1-methyltransferase | tRNA N1-methyltransferase | tRNA_N1-methyltransferase | 6 |
IPR053619 | 53,619 | KEOPS complex subunit CTAG/PCC1 | KEOPS_CTAG/PCC1 | Family | 43 | true | false | This family of proteins is involved in the post-transcriptional modification of transfer RNAs (tRNAs). Specifically, they play a crucial role in the biosynthesis of the threonylcarbamoyladenosine (t(6)A) modification at position 37 adjacent to the anticodon in tRNAs that read codons starting with adenine. This modifica... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040853"
] | [
"KEOPS_CTAG/PCC1"
] | [
43
] | 1 | [] | [] | [] | 0 | [
"3enc",
"3eno",
"5jmv",
"7a67",
"8unk",
"8up5",
"9d85"
] | 7 | [
"PUB00106024"
] | [
"23945934"
] | [
"Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
43
] | 1 | [] | [] | 0 | true | Family | KEOPS complex subunit CTAG/PCC1 | KEOPS complex subunit CTAG/PCC1 | KEOPS_CTAG/PCC1 | 9 |
IPR053620 | 53,620 | Staphylopine dehydrogenase | Staphylopine_dehydrogenase | Family | 60 | true | false | This family of proteins includes enzymes that catalyze the NADPH-dependent reductive condensation of pyruvate with an intermediate to produce a compound known as staphylopine. Staphylopine is a metallophore involved in the transport and acquisition of essential metals such as nickel, cobalt, zinc, copper, and iron, whi... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033600"
] | [
"Staphylopine_dehydrogenase"
] | [
60
] | 1 | [] | [] | [] | 0 | [
"6c4r",
"6c4t",
"6gmz",
"6h31",
"6h3d",
"6h3f"
] | 6 | [
"PUB00081137"
] | [
"27230378"
] | [
"Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Staphylococcaceae"
] | [
60
] | 1 | [] | [] | 0 | true | Family | Staphylopine dehydrogenase | Staphylopine dehydrogenase | Staphylopine_dehydrogenase | 4 |
IPR053621 | 53,621 | Alpha-glucan branching enzyme | Alpha-glucan_branching_enzyme | Family | 42 | true | false | This family of proteins is involved in the modification of alpha-glucans, specifically in the creation of branch points within these molecules. The enzyme action involves cleaving alpha-1,4 glycosidic bonds and transferring the resulting oligosaccharides to an alpha-1,6 position, thus generating branched polysaccharide... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041133"
] | [
"Alpha-glucan_branching_enzyme"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"3n8t",
"3n92",
"3n98",
"5wu7"
] | 4 | [
"PUB00058786",
"PUB00090453"
] | [
"21104698",
"16885460"
] | [
"Structural basis for branching-enzyme activity of glycoside hydrolase family 57: structure and stability studies of a novel branching enzyme from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1.",
"A novel branching enzyme of the GH-57 family in the hyperthermophilic archaeon Thermococcus kodakara... | [
2011,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Alpha-glucan branching enzyme | Alpha-glucan branching enzyme | Alpha-glucan_branching_enzyme | 9 |
IPR053624 | 53,624 | Cytochrome c oxidase subunit 2-like | Cytochrome_c_oxidase_su2-like | Family | 60 | true | false | This family of proteins includes components of the respiratory chain that are involved in the terminal stage of aerobic respiration. They play a crucial role in energy production by catalyzing the reduction of oxygen to water. The proteins within this family are responsible for transferring electrons from a specific qu... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041074"
] | [
"Cytochrome_c_oxidase_su2-like"
] | [
60
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106158",
"PUB00106159",
"PUB00106160"
] | [
"1372250",
"7984110",
"9079667"
] | [
"An archaebacterial terminal oxidase combines core structures of two mitochondrial respiratory complexes.",
"The purified SoxABCD quinol oxidase complex of Sulfolobus acidocaldarius contains a novel haem.",
"The archaeal SoxABCD complex is a proton pump in Sulfolobus acidocaldarius."
] | [
1992,
1994,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
60
] | 1 | [] | [] | 0 | true | Family | Cytochrome c oxidase subunit 2-like | Cytochrome c oxidase subunit 2-like | Cytochrome_c_oxidase_su2-like | 9 |
IPR053625 | 53,625 | NADPH-dependent hydrogen-evolving hydrogenase | NADPH-dep_hydrogenase | Family | 40 | true | false | This family of proteins includes subunits that are part of a bifunctional enzyme complex with NADPH-dependent hydrogen-evolving hydrogenase activity, coupled with sulfur reduction. These proteins are involved in hydrogen cycling during fermentative growth, catalyzing the reduction of protons to produce hydrogen gas. Th... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040836"
] | [
"NADPH-dep_hydrogenase"
] | [
40
] | 1 | [] | [] | [] | 0 | [
"9e15",
"9e1j",
"9nez",
"9nf0"
] | 4 | [
"PUB00033242",
"PUB00106003",
"PUB00106004"
] | [
"7704275",
"11265463",
"11054105"
] | [
"Characterization of the locus encoding the [Ni-Fe] sulfhydrogenase from the archaeon Pyrococcus furiosus: evidence for a relationship to bacterial sulfite reductases.",
"Hydrogenases I and II from Pyrococcus furiosus.",
"Enzymes of hydrogen metabolism in Pyrococcus furiosus."
] | [
1995,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | NADPH-dependent hydrogen-evolving hydrogenase | NADPH-dependent hydrogen-evolving hydrogenase | NADPH-dep_hydrogenase | 6 |
IPR053626 | 53,626 | Hydrogenase large subunit | Hydrogenase_lg_subunit | Family | 37 | true | false | This family of proteins includes components of a bifunctional enzyme complex that is involved in hydrogen and sulfur metabolism. Members of this family are capable of catalyzing the reduction of protons to produce hydrogen gas, a process that is coupled with the reduction of sulfur compounds. These proteins are known t... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040828"
] | [
"Hydrogenase_lg_subunit"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106001",
"PUB00106002",
"PUB00106003"
] | [
"10714990",
"11133967",
"11265463"
] | [
"Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.",
"Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.",
"Hydrogenases I and II from Py... | [
2000,
2001,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
37
] | 1 | [] | [] | 0 | true | Family | Hydrogenase large subunit | Hydrogenase large subunit | Hydrogenase_lg_subunit | 5 |
IPR053627 | 53,627 | UDP-sugar dehydrogenase | UDP-sugar_DH | Family | 40 | true | false | This family of proteins includes enzymes that are responsible for the oxidation of specific nucleotide sugars, converting them into their respective uronic acid derivatives. The reaction involves the reduction of NAD(+) and is a key step in the biosynthesis of polysaccharides. Members of this family are characterized b... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040825"
] | [
"UDP-sugar_DH"
] | [
40
] | 1 | [] | [] | [] | 0 | [
"4r16"
] | 1 | [
"PUB00105998",
"PUB00105999"
] | [
"17565184",
"25305481"
] | [
"Purification, crystallization and preliminary X-ray diffraction studies of a putative UDP-N-acetyl-D-mannosamine dehydrogenase from Pyrococcus horikoshii OT3.",
"Crystal structure of product-bound complex of UDP-N-acetyl-d-mannosamine dehydrogenase from Pyrococcus horikoshii OT3."
] | [
2007,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | UDP-sugar dehydrogenase | UDP-sugar dehydrogenase | UDP-sugar_DH | 9 |
IPR053628 | 53,628 | Heme-copper respiratory oxidase subunit 1 | Heme-copper_oxidase_sub1 | Family | 62 | true | false | This family of proteins includes members that are integral components of the enzyme complex responsible for the terminal step of aerobic respiration. They are involved in the transfer of electrons from quinol to a binuclear center consisting of heme A3 and Cu(B), which is crucial for the catalytic reduction of oxygen t... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041075"
] | [
"Heme-copper_oxidase_sub1"
] | [
62
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106158",
"PUB00106159",
"PUB00106160"
] | [
"1372250",
"7984110",
"9079667"
] | [
"An archaebacterial terminal oxidase combines core structures of two mitochondrial respiratory complexes.",
"The purified SoxABCD quinol oxidase complex of Sulfolobus acidocaldarius contains a novel haem.",
"The archaeal SoxABCD complex is a proton pump in Sulfolobus acidocaldarius."
] | [
1992,
1994,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
62
] | 1 | [] | [] | 0 | true | Family | Heme-copper respiratory oxidase subunit 1 | Heme-copper respiratory oxidase subunit 1 | Heme-copper_oxidase_sub1 | 6 |
IPR053629 | 53,629 | NADPH-dependent Sulfhydrogenase Complex Subunit | NADPH_Sulfhydrogenase_Subunit | Family | 40 | true | false | This family of proteins includes components of a bifunctional enzyme complex that is involved in hydrogen and sulfur metabolism. Members of this family are involved in the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur and function as NADPH-dependent hydrogen-evolving hydrogenases. They ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040833"
] | [
"NADPH_Sulfhydrogenase_Subunit"
] | [
40
] | 1 | [] | [] | [] | 0 | [
"9nez",
"9nf0"
] | 2 | [
"PUB00033242",
"PUB00106003",
"PUB00106005"
] | [
"7704275",
"11265463",
"8389482"
] | [
"Characterization of the locus encoding the [Ni-Fe] sulfhydrogenase from the archaeon Pyrococcus furiosus: evidence for a relationship to bacterial sulfite reductases.",
"Hydrogenases I and II from Pyrococcus furiosus.",
"Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase o... | [
1995,
2001,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | NADPH-dependent Sulfhydrogenase Complex Subunit | NADPH-dependent Sulfhydrogenase Complex Subunit | NADPH_Sulfhydrogenase_Subunit | 9 |
IPR053630 | 53,630 | tRNA Cytosine-C(5)-Methyltransferase | tRNA_Cytosine-C(5)-MTase | Family | 40 | true | false | This family of proteins includes enzymes that catalyze the AdoMet-dependent methylation of cytosine in RNA molecules. They are responsible for the specific modification of cytosine at position 49 in tRNA, resulting in the formation of 5-methylcytosine (m5C49). The activity of these enzymes is modulated by the presence ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040814"
] | [
"tRNA_Cytosine-C(5)-MTase"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045441"
] | [
"17470432"
] | [
"Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | tRNA Cytosine-C(5)-Methyltransferase | tRNA Cytosine-C(5)-Methyltransferase | tRNA_Cytosine-C(5)-MTase | 2 |
IPR053631 | 53,631 | IucA/IucC-like synthase | IucA/IucC-like_synthase | Family | 68 | true | false | This family of proteins is involved in the biosynthesis of siderophores, specifically staphyloferrin B, which is a compound that bacteria use to sequester iron from the environment. Members of this family catalyze a key step in the biosynthetic pathway, which is the condensation of L-2,3-diaminopropionic acid with citr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033586"
] | [
"IucA/IucC-like_synthase"
] | [
68
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092872"
] | [
"29483190"
] | [
"SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Staphylococcus"
] | [
68
] | 1 | [] | [] | 0 | true | Family | IucA/IucC-like synthase | IucA/IucC-like synthase | IucA/IucC-like_synthase | 7 |
IPR053632 | 53,632 | Glycosyl Hydrolase 121 | GH121 | Family | 55 | true | false | This family of proteins includes enzymes with beta-L-arabinobiosidase activity, which are involved in the hydrolysis of L-arabinofuranose-beta-1,2-L-arabinofuranose disaccharides from various substrates. These enzymes exhibit specificity for certain arabinofuranose-containing disaccharides, particularly those unmodifie... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041578"
] | [
"GH121"
] | [
55
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151327"
] | [
"21149454"
] | [
"Molecular cloning and characterization of a beta-L-Arabinobiosidase in Bifidobacterium longum that belongs to a novel glycoside hydrolase family."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Bifidobacterium"
] | [
55
] | 1 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 121 | Glycosyl Hydrolase 121 | GH121 | 1 |
IPR053633 | 53,633 | Serine/threonine-protein acetyltransferase | Ser/Thr_acetyltransferase | Family | 69 | true | false | This family of proteins includes serine/threonine-protein acetyltransferases that are known to be translocated into host cells during infection. They are responsible for the acetylation of serine and threonine residues on host proteins. This modification can alter the function of the host proteins and is associated wit... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041334"
] | [
"Ser/Thr_acetyltransferase"
] | [
69
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106337",
"PUB00106338"
] | [
"14645268",
"25739698"
] | [
"XopC and XopJ, two novel type III effector proteins from Xanthomonas campestris pv. vesicatoria.",
"The Xanthomonas campestris type III effector XopJ proteolytically degrades proteasome subunit RPT6."
] | [
2003,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
69
] | 1 | [] | [] | 0 | true | Family | Serine/threonine-protein acetyltransferase | Serine/threonine-protein acetyltransferase | Ser/Thr_acetyltransferase | 1 |
IPR053634 | 53,634 | Actinobacterial Glucosamine Kinase | Actino_Glucosamine_Kinase | Family | 57 | true | false | This family of proteins includes enzymes that are responsible for the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. These enzymes play a role in the metabolism of GlcNAc by incorporating exogenous GlcN into the bacterial GlcNAc metabolic pathways. They are characterized by their in... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041273"
] | [
"Actino_Glucosamine_Kinase"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094449"
] | [
"31088917"
] | [
"Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Mycobacteriaceae"
] | [
57
] | 1 | [] | [] | 0 | true | Family | Actinobacterial Glucosamine Kinase | Actinobacterial Glucosamine Kinase | Actino_Glucosamine_Kinase | 9 |
IPR053635 | 53,635 | Metallo-dependent Hydrolases FwdA/FmdA | Metallo-hydrolase_FwdA/FmdA | Family | 53 | true | false | This family of proteins includes metallo-dependent hydrolases that are characterized by their requirement for metal ions to catalyze the hydrolysis of various substrates. Members of this family, such as FwdA, are involved in fundamental biochemical processes and can have diverse substrate specificities, which may inclu... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042911"
] | [
"Metallo-hydrolase_FwdA/FmdA"
] | [
53
] | 1 | [] | [] | [] | 0 | [
"5t5i",
"5t5m",
"5t61"
] | 3 | [
"PUB00153614",
"PUB00153615"
] | [
"27846502",
"19627604"
] | [
"The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters.",
"Quantitative proteomics of nutrient limitation in the hydrogenotrophic methanogen Methanococcus maripaludis."
] | [
2016,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
53
] | 1 | [] | [] | 0 | true | Family | Metallo-dependent Hydrolases FwdA/FmdA | Metallo-dependent Hydrolases FwdA/FmdA | Metallo-hydrolase_FwdA/FmdA | 8 |
IPR053637 | 53,637 | Archaeal lipid biosynthesis protein FwdD | Archaeal_lipid_biosynth_FwdD | Family | 48 | true | false | This family of proteins includes FwdD, which is involved in the biosynthesis of archaeal membrane lipids. Members of this family are likely to participate in the formation of cyclic 2,3-diphosphoglycerate (cDPG) from 3-phosphoglycerate, a key intermediate in the biosynthetic pathway. The activity of these proteins is e... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042908"
] | [
"Archaeal_lipid_biosynth_FwdD"
] | [
48
] | 1 | [] | [] | [] | 0 | [
"5t5i",
"5t5m",
"5t61"
] | 3 | [
"PUB00153614",
"PUB00153615"
] | [
"27846502",
"19627604"
] | [
"The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters.",
"Quantitative proteomics of nutrient limitation in the hydrogenotrophic methanogen Methanococcus maripaludis."
] | [
2016,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Methanomada group"
] | [
48
] | 1 | [] | [] | 0 | true | Family | Archaeal lipid biosynthesis protein FwdD | Archaeal lipid biosynthesis protein FwdD | Archaeal_lipid_biosynth_FwdD | 7 |
IPR053638 | 53,638 | Hydrogenase Small Subunit-like | Hydrogenase_Small_Subunit-like | Family | 36 | true | false | This family of proteins includes subunits of a bifunctional enzyme complex that is involved in hydrogen and sulfur metabolism. Members of this family are involved in the catalytic process that reduces protons to produce hydrogen gas, a reaction that is part of fermentative growth in certain microorganisms. These protei... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040831"
] | [
"Hydrogenase_Small_Subunit-like"
] | [
36
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106001",
"PUB00106002",
"PUB00106003"
] | [
"10714990",
"11133967",
"11265463"
] | [
"Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.",
"Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.",
"Hydrogenases I and II from Py... | [
2000,
2001,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
36
] | 1 | [] | [] | 0 | true | Family | Hydrogenase Small Subunit-like | Hydrogenase Small Subunit-like | Hydrogenase_Small_Subunit-like | 7 |
IPR053639 | 53,639 | Sulfhydrogenase gamma subunit-like | Sulfhydrogenase_gamma-like | Family | 35 | true | false | This family of proteins includes components of a bifunctional enzyme complex known for its role in hydrogen and sulfur metabolism. Members of this family are involved in the catalysis of hydrogen sulfide production in the cytoplasm, utilizing elemental sulfur as a substrate. They are also associated with hydrogen-evolv... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040830"
] | [
"Sulfhydrogenase_gamma-like"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106001",
"PUB00106002",
"PUB00106003"
] | [
"10714990",
"11133967",
"11265463"
] | [
"Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.",
"Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.",
"Hydrogenases I and II from Py... | [
2000,
2001,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
35
] | 1 | [] | [] | 0 | true | Family | Sulfhydrogenase gamma subunit-like | Sulfhydrogenase gamma subunit-like | Sulfhydrogenase_gamma-like | 5 |
IPR053640 | 53,640 | YsgD-like | YsgD-like | Family | 100 | true | false | This family of proteins is involved in various cellular processes. The specific functions of the family members may include enzymatic activity, structural roles, regulatory functions, or involvement in signaling pathways. Each protein within the family may have a distinct function or set of functions, which can be infl... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF041266",
"PF28199"
] | [
"YsgD-like",
"YsgD"
] | [
100,
99
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763",
"PUB00106277"
] | [
"30837344",
"22153074"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes.",
"Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo."
] | [
2019,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
100
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YsgD-like | YsgD-like | YsgD-like | 2 |
IPR053641 | 53,641 | HdrA heterodisulfide reductase subunit | HdrA_heterodisulfide_rdct | Family | 40 | true | false | This family of proteins is involved in the energy metabolism process specific to certain archaea, particularly in the context of methanogenesis. Members of this family are components of a larger enzymatic complex that facilitates the reversible reduction of a heterodisulfide formed between coenzyme M (CoM-SH) and coenz... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041778"
] | [
"HdrA_heterodisulfide_rdct"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088716"
] | [
"19968794"
] | [
"Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | HdrA heterodisulfide reductase subunit | HdrA heterodisulfide reductase subunit | HdrA_heterodisulfide_rdct | 4 |
IPR053642 | 53,642 | Zinc metalloprotease TldD-like | Zinc_metalloprotease_TldD | Family | 52 | true | false | This family of proteins includes zinc metalloproteases that are capable of degrading various protein substrates such as azocasein in vitro. Members of this family are characterized by a conserved motif that is likely to constitute the active site necessary for their metalloprotease activity. These enzymes play a role i... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040952"
] | [
"Zinc_metalloprotease_TldD"
] | [
52
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075366"
] | [
"22950735"
] | [
"An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
52
] | 1 | [] | [] | 0 | true | Family | Zinc metalloprotease TldD-like | Zinc metalloprotease TldD-like | Zinc_metalloprotease_TldD | 1 |
IPR053643 | 53,643 | 23S rRNA methylase regulatory peptide | 23S_rRNA_methylase_reg | Family | 56 | true | false | This family of proteins includes peptides that regulate the synthesis of resistance proteins against erythromycin by a control mechanism. These peptides are typically found upstream of the erythromycin resistance protein gene and are involved in the response to the presence of the antibiotic, thereby contributing to th... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033690"
] | [
"23S_rRNA_methylase_reg"
] | [
56
] | 1 | [] | [] | [] | 0 | [
"3j7z"
] | 1 | [
"PUB00091060",
"PUB00105246"
] | [
"28369621",
"25306253"
] | [
"Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain.",
"Drug sensing by the ribosome induces translational arrest via active site perturbation."
] | [
2017,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"plasmids"
] | [
54,
2
] | 2 | [] | [] | 0 | true | Family | 23S rRNA methylase regulatory peptide | 23S rRNA methylase regulatory peptide | 23S_rRNA_methylase_reg | 7 |
IPR053644 | 53,644 | Sulfhydrogenase Complex Subunit Beta | Sulfhydrogenase_beta | Family | 34 | true | false | This family of proteins includes components of a bifunctional enzyme complex known for its role in hydrogen and sulfur metabolism. Members of this family are involved in the evolution of hydrogen gas and the reduction of sulfur. They exhibit activity with both NAD and NADPH and are implicated in the production of hydro... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040829"
] | [
"Sulfhydrogenase_beta"
] | [
34
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106001",
"PUB00106002",
"PUB00106003"
] | [
"10714990",
"11133967",
"11265463"
] | [
"Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.",
"Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.",
"Hydrogenases I and II from Py... | [
2000,
2001,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
34
] | 1 | [] | [] | 0 | true | Family | Sulfhydrogenase Complex Subunit Beta | Sulfhydrogenase Complex Subunit Beta | Sulfhydrogenase_beta | 3 |
IPR053645 | 53,645 | CheY-P phosphatase CheC | CheY-P_phosphatase_CheC | Family | 39 | true | false | This family of proteins is involved in the regulation of chemotaxis by modulating the levels of phosphorylated CheY (CheY-P), which is a response regulator involved in flagellar motor control. Members of this family act as phosphatases, catalyzing the dephosphorylation of CheY-P to CheY, thereby reversing the signal tr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041093"
] | [
"CheY-P_phosphatase_CheC"
] | [
39
] | 1 | [] | [] | [] | 0 | [
"1xkr",
"2f9z"
] | 2 | [
"PUB00038320",
"PUB00040594"
] | [
"15546616",
"16469702"
] | [
"Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX.",
"A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation."
] | [
2004,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Thermotogae"
] | [
39
] | 1 | [] | [] | 0 | true | Family | CheY-P phosphatase CheC | CheY-P phosphatase CheC | CheY-P_phosphatase_CheC | 1 |
IPR053646 | 53,646 | HdrC heterodisulfide reductase subunit C | HdrC_heterodisulfide_reductase | Family | 38 | true | false | This family of proteins is involved in the energy metabolism process specific to methanogenic archaea. They play a crucial role in the final step of methane biosynthesis, where they participate in the reduction of heterodisulfide bonds between coenzyme M (CoM-SH) and coenzyme B (CoB-SH). This reaction is essential for ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041779"
] | [
"HdrC_heterodisulfide_reductase"
] | [
38
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088716"
] | [
"19968794"
] | [
"Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcinaceae",
"bioreactor metagenome"
] | [
37,
1
] | 2 | [] | [] | 0 | true | Family | HdrC heterodisulfide reductase subunit C | HdrC heterodisulfide reductase subunit C | HdrC_heterodisulfide_reductase | 5 |
IPR053647 | 53,647 | Riboflavin Transporter RibV | Riboflavin_Transporter_RibV | Family | 47 | true | false | This family of proteins is involved in the cellular uptake of riboflavin, which is a vital nutrient also known as vitamin B2. Riboflavin is essential for numerous cellular processes as it is a precursor for the synthesis of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), both of which are key cofacto... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF043064"
] | [
"Riboflavin_Transporter_RibV"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153514",
"PUB00153515"
] | [
"31308405",
"20488990"
] | [
"Environmental conditions shape the nature of a minimal bacterial genome.",
"Creation of a bacterial cell controlled by a chemically synthesized genome."
] | [
2019,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Mollicutes"
] | [
47
] | 1 | [] | [] | 0 | true | Family | Riboflavin Transporter RibV | Riboflavin Transporter RibV | Riboflavin_Transporter_RibV | 7 |
IPR053648 | 53,648 | tRNA Cytidine-2'-O-Methyltransferase | tRNA_Cytidine-2'-O-MTase | Family | 46 | true | false | This family of proteins includes enzymes that are responsible for the methylation of cytidine residues in tRNA molecules. Specifically, they catalyze the 2'O-methylation of cytidine at the 32nd position, resulting in the formation of 2'O-methylcytidine. This modification is crucial for the proper functioning of tRNA. T... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041077"
] | [
"tRNA_Cytidine-2'-O-MTase"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"4cnf",
"4cng"
] | 2 | [
"PUB00090189"
] | [
"24951554"
] | [
"Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
46
] | 1 | [] | [] | 0 | true | Family | tRNA Cytidine-2'-O-Methyltransferase | tRNA Cytidine-2'-O-Methyltransferase | tRNA_Cytidine-2'-O-MTase | 4 |
IPR053649 | 53,649 | Polysaccharide Lyase 2 | PL_2 | Family | 65 | true | false | This family of proteins includes enzymes that act on pectic substances by cleaving the glycosidic linkages between galacturonate residues. Members of this family are involved in the degradation of pectate, a component of the plant cell wall, by catalyzing the cleavage of polygalacturonate and oligogalacturonates to pro... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041904"
] | [
"PL_2"
] | [
65
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014561",
"PUB00152988"
] | [
"1766386",
"10383957"
] | [
"Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation.",
"The exopolygalacturonate lyase PelW and the oligogalacturonate lyase Ogl, two cytoplasmic enzymes of pectin catabolism in Erwinia chrysanthemi 3937."
] | [
1991,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
65
] | 1 | [] | [] | 0 | true | Family | Polysaccharide Lyase 2 | Polysaccharide Lyase 2 | PL_2 | 9 |
IPR053650 | 53,650 | Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase | Sugar-1P_NT/AT | Family | 46 | true | true | This family of proteins includes bifunctional enzymes that are involved in the synthesis of nucleotide sugars, which are essential for glycosylation processes. Members of this family exhibit multiple enzymatic activities, including acetyltransferase and nucleotidylyltransferase functions. They are capable of transferri... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041173"
] | [
"Sugar-1P_NT/AT"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"2ggo",
"2ggq",
"5z09",
"5z0a"
] | 4 | [
"PUB00093666",
"PUB00106219"
] | [
"15598657",
"20400541"
] | [
"Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7.",
"Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7."
] | [
2005,
2010
] | 2 | [
"IPR050065"
] | [] | 1 | 0 | 1 | [
"Sulfolobaceae"
] | [
46
] | 1 | [] | [] | 0 | true | Family | Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase | Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase | Sugar-1P_NT/AT | 2 |
IPR053652 | 53,652 | Phr signaling regulator | Phr_regulator | Family | 45 | true | false | This family of proteins includes signaling molecules that play a crucial role in the regulation of genetic competence development in bacteria. They are secreted and subsequently need to be imported back into the cell to exert their function. Once inside, they act by inhibiting specific regulatory proteins, which in tur... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF038040",
"PF28200"
] | [
"Phr_regulator",
"Phr_regulator"
] | [
41,
45
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus",
"Caudoviricetes"
] | [
42,
3
] | 2 | [] | [] | 0 | true | Family | Phr signaling regulator | Phr signaling regulator | Phr_regulator | 7 |
IPR053653 | 53,653 | Cell Division Membrane-Interacting Protein | Cell_Div_Membrane-Interact | Family | 48 | true | false | This family of proteins is involved in cellular division processes. Members of this family, including CdvA, are known to polymerize between segregating nucleoids during cell division. They form structures that change in size as the cell constricts. Specifically, CdvA is noted for its role in interacting with the cell m... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041007"
] | [
"Cell_Div_Membrane-Interact"
] | [
48
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057104",
"PUB00083231"
] | [
"21255729",
"18987308"
] | [
"Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.",
"A unique cell division machinery in the Archaea."
] | [
2011,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
48
] | 1 | [] | [] | 0 | true | Family | Cell Division Membrane-Interacting Protein | Cell Division Membrane-Interacting Protein | Cell_Div_Membrane-Interact | 2 |
IPR053654 | 53,654 | Cell division protein B | CdvB | Family | 47 | true | true | CdvA, CdvB, and CdvC form a complex that polymerises between segregating nucleoids during cell division. This complex plays a crucial role in maintaining the structure that becomes progressively smaller as the cell constricts. The full-length CdvB protein is part of the archaeal cell division machinery and functions as... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041008"
] | [
"Cell_Div_Complex_Comp"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00050019",
"PUB00057104",
"PUB00083231"
] | [
"19008417",
"21255729",
"18987308"
] | [
"A role for the ESCRT system in cell division in archaea.",
"Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.",
"A unique cell division machinery in the Archaea."
] | [
2008,
2011,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
47
] | 1 | [] | [] | 0 | true | Family | Cell division protein B | Cell division protein B | CdvB | 3 |
IPR053655 | 53,655 | Hexaprenyl pyrophosphate synthase | HexPP_synthase | Family | 46 | true | false | This family of proteins is involved in the biosynthesis of polyprenyl pyrophosphates, which are key intermediates in the synthesis of isoprenoid compounds. Members of this family function as enzymes that facilitate the E-type condensation reactions between isopentenyl pyrophosphate (IPP) and various allylic substrates,... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040936"
] | [
"HexPP_synthase"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"2azj",
"2azk"
] | 2 | [
"PUB00039462",
"PUB00106076"
] | [
"16291686",
"11790729"
] | [
"Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.",
"Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus."
] | [
2005,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
46
] | 1 | [] | [] | 0 | true | Family | Hexaprenyl pyrophosphate synthase | Hexaprenyl pyrophosphate synthase | HexPP_synthase | 5 |
IPR053656 | 53,656 | Glycerate kinase type-1 | Glycerate_kinase-1 | Family | 46 | true | false | This family of proteins includes enzymes that are responsible for the ATP-dependent phosphorylation of D-glycerate, resulting in the production of 2-phosphoglycerate. Members of this family are capable of using not only ATP but also other nucleotides such as GTP, CTP, UTP, ADP, AMP, or pyrophosphate as phosphate donors... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041176"
] | [
"Glycerate_kinase-1"
] | [
46
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106223"
] | [
"19690808"
] | [
"A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
46
] | 1 | [] | [] | 0 | true | Family | Glycerate kinase type-1 | Glycerate kinase type-1 | Glycerate_kinase-1 | 7 |
IPR053657 | 53,657 | Ced system-associated DNA import protein | Ced-DNA_import | Family | 47 | true | false | This family of proteins is associated with the Ced system, which plays a role in the process of DNA import. Members of this family are implicated in the transfer of genetic material into the cell, which is a crucial step for various biological processes including horizontal gene transfer, transformation, and adaptation... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041017"
] | [
"Ced-DNA_import"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106133"
] | [
"26884154"
] | [
"The archaeal Ced system imports DNA."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
47
] | 1 | [] | [] | 0 | true | Family | Ced system-associated DNA import protein | Ced system-associated DNA import protein | Ced-DNA_import | 3 |
IPR053658 | 53,658 | Cell Division Coordination Protein | Cdv_Coordination_Protein | Family | 47 | true | false | This family of proteins is involved in cellular division processes. Members of this family are believed to play a role in the coordination of cell division machinery, potentially by interacting with other cell division proteins to ensure proper division of the cell. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041009"
] | [
"Cdv_Coordination_Protein"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106127"
] | [
"24399085"
] | [
"Deletion of cdvB paralogous genes of Sulfolobus acidocaldarius impairs cell division."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
47
] | 1 | [] | [] | 0 | true | Family | Cell Division Coordination Protein | Cell Division Coordination Protein | Cdv_Coordination_Protein | 3 |
IPR053659 | 53,659 | DNA Double-strand Break Repair Helicase HerA | DSB_Repair_Helicase_HerA | Family | 29 | true | false | This family of proteins is involved in the cellular process of DNA double-strand break (DSB) repair. Members of this family function in conjunction with other proteins, such as NurA, to facilitate the resection of the 5' strand of DNA at the site of damage, which is a critical step in the repair process. The resection ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040819"
] | [
"DSB_Repair_Helicase_HerA"
] | [
29
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105991"
] | [
"18957200"
] | [
"The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
29
] | 1 | [] | [] | 0 | true | Family | DNA Double-strand Break Repair Helicase HerA | DNA Double-strand Break Repair Helicase HerA | DSB_Repair_Helicase_HerA | 1 |
IPR053661 | 53,661 | GHMP kinase | GHMP_kinase | Family | 40 | true | false | This family of proteins includes enzymes that are involved in the phosphorylation of (R)-mevalonate 5-phosphate to (R)-mevalonate 5-diphosphate. These enzymes play a crucial role in the mevalonate pathway, which is responsible for the production of isopentenyl diphosphate, an essential precursor for the synthesis of is... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040957"
] | [
"GHMP_kinase"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085102"
] | [
"23378249"
] | [
"Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
40
] | 1 | [] | [] | 0 | true | Family | GHMP kinase | GHMP kinase | GHMP_kinase | 6 |
IPR053662 | 53,662 | Geranylfarnesyl diphosphate synthase-like | GFPP_synthase-like | Family | 28 | true | false | This family of proteins is involved in the biosynthesis of polyprenyl compounds, which are critical components in various biological processes. Members of this family function as enzymes that catalyze the condensation of isopentenyl pyrophosphate with allylic pyrophosphates, leading to the production of geranylfarnesyl... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040627"
] | [
"GFPP_synthase-like"
] | [
28
] | 1 | [] | [] | [] | 0 | [
"3ipi"
] | 1 | [
"PUB00105859"
] | [
"20097171"
] | [
"Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Methanosarcina"
] | [
28
] | 1 | [] | [] | 0 | true | Family | Geranylfarnesyl diphosphate synthase-like | Geranylfarnesyl diphosphate synthase-like | GFPP_synthase-like | 5 |
IPR053663 | 53,663 | Thiosulfate dehydrogenase [quinone] large subunit | TQO_large_subunit | Family | 37 | true | false | This family of proteins includes thiosulfate dehydrogenase [quinone] large subunits, which are involved in the sulfur oxidation process. They are known to couple the oxidation of sulfur to the reduction of dioxygen, thereby playing a crucial role in the sulfur cycle. These proteins are also responsible for transferring... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041179"
] | [
"TQO_large_subunit"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015233"
] | [
"15306018"
] | [
"Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
37
] | 1 | [] | [] | 0 | true | Family | Thiosulfate dehydrogenase [quinone] large subunit | Thiosulfate dehydrogenase [quinone] large subunit | TQO_large_subunit | 3 |
IPR053664 | 53,664 | Non-flavoprotein flavin reductase | NFP_flavin_reductase | Family | 43 | true | false | This family of proteins is involved in the reduction of free flavins, including FMN, FAD, and riboflavin, using NADH as an electron donor. The reduced flavins are then transferred to a larger component, typically the HpaB component, which is part of the same enzymatic system. These proteins are characterized by their a... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF042921"
] | [
"NFP_flavin_reductase"
] | [
43
] | 1 | [] | [] | [] | 0 | [
"2ecr",
"2ecu",
"2ed4"
] | 3 | [
"PUB00047367"
] | [
"17729270"
] | [
"Crystal structure of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8: Structural basis for the flavin affinity."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Thermaceae"
] | [
43
] | 1 | [] | [] | 0 | true | Family | Non-flavoprotein flavin reductase | Non-flavoprotein flavin reductase | NFP_flavin_reductase | 8 |
IPR053666 | 53,666 | [5-(aminomethyl)furan-3-yl]methyl phosphate kinase | Furan-3-ylmethyl_P_kinase | Family | 36 | true | false | This family of proteins is involved in the biosynthesis of modified nucleotides. Members of this family are known to catalyze the phosphorylation of 5-(aminomethyl)-3-furanmethanol phosphate (F1-P) using ATP to produce 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP). Additionally, they have adenylate kinase activit... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040622"
] | [
"Furan-3-ylmethyl_P_kinase"
] | [
36
] | 1 | [] | [] | [] | 0 | [
"7qrh"
] | 1 | [
"PUB00077118"
] | [
"26100040"
] | [
"Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Methanococcales"
] | [
36
] | 1 | [] | [] | 0 | true | Family | [5-(aminomethyl)furan-3-yl]methyl phosphate kinase | [5-(aminomethyl)furan-3-yl]methyl phosphate kinase | Furan-3-ylmethyl_P_kinase | 5 |
IPR053667 | 53,667 | Glycosyl Hydrolase 3 Beta-Xylosidase | GH3_Beta-Xylosidase | Family | 50 | true | false | This family of proteins includes enzymes with beta-xylosidase activity, which play a role in the degradation of ulvan, a major polysaccharide in the cell walls of green seaweed. Members of this family catalyze the hydrolysis of xylosides, specifically converting Xyl-Rha3S oligosaccharides into xylose and 3-sulfated rha... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041579"
] | [
"GH3_Beta-Xylosidase"
] | [
50
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093668"
] | [
"31285597"
] | [
"A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteroidota"
] | [
50
] | 1 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 3 Beta-Xylosidase | Glycosyl Hydrolase 3 Beta-Xylosidase | GH3_Beta-Xylosidase | 8 |
IPR053668 | 53,668 | Phosphatase RapA inhibitor | PhrA_inhibitor | Family | 27 | true | false | This family of proteins includes signaling molecules that play a role in the regulation of sporulation [ , ]. They are secreted and subsequently need to be imported into the cell to exert their function intracellularly. Members of this family act as inhibitors of specific phosphatase activities, such as that of RapA [ ... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF033799",
"PF28201"
] | [
"PhrA_inhibitor",
"PhrA_inhibitor"
] | [
27,
27
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004883",
"PUB00045968",
"PUB00105335",
"PUB00162453",
"PUB00162454"
] | [
"8643670",
"12897006",
"22267516",
"11923303",
"9238025"
] | [
"Cell-cell communication regulates the effects of protein aspartate phosphatases on the phosphorelay controlling development in Bacillus subtilis.",
"Molecular analysis of Phr peptide processing in Bacillus subtilis.",
"Bacillus subtilis RapA phosphatase domain interaction with its substrate, phosphorylated Spo... | [
1996,
2003,
2012,
2002,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Bacillus"
] | [
27
] | 1 | [] | [] | 0 | true | Family | Phosphatase RapA inhibitor | Phosphatase RapA inhibitor | PhrA_inhibitor | 7 |
IPR053669 | 53,669 | Adenosylcobinamide-phosphate Guanylyltransferase | AdoCbi-P_Guanylyltransferase | Family | 33 | true | false | This family of proteins includes guanylyltransferases that are responsible for the synthesis of adenosylcobinamide-GDP from adenosylcobinamide-phosphate and GTP, a key step in the biosynthesis of adenosylcobalamin, also known as coenzyme B12. Members of this family bind GTP specifically and do not utilize other nucleot... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045495"
] | [
"AdoCbi-P_Guanylyltransferase"
] | [
33
] | 1 | [] | [] | [] | 0 | [
"2mzb",
"3rsb"
] | 2 | [
"PUB00045885",
"PUB00153612"
] | [
"18260642",
"19489548"
] | [
"Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis.",
"Biochemical characterization of the GTP:adenosylcobinamide-phosphate guanylyltransferase (CobY) enzyme of the hyperthermophilic archaeon Methanocaldococcus jannaschii."
] | [
2008,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Methanococcales"
] | [
33
] | 1 | [] | [] | 0 | true | Family | Adenosylcobinamide-phosphate Guanylyltransferase | Adenosylcobinamide-phosphate Guanylyltransferase | AdoCbi-P_Guanylyltransferase | 3 |
IPR053670 | 53,670 | Mandelate racemase/muconate lactonizing-like enzyme | MR_MLE-like_enzyme | Family | 27 | true | false | This family of proteins is involved in the pentose oxidation pathway, where it functions to convert D-arabinonate into 2-keto-3-deoxy-D-arabinonate by catalyzing a dehydration reaction. Members of this family are characterized by their enzymatic activity in this specific metabolic process, which ultimately leads to the... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040866"
] | [
"MR_MLE-like_enzyme"
] | [
27
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083786"
] | [
"16849334"
] | [
"Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
27
] | 1 | [] | [] | 0 | true | Family | Mandelate racemase/muconate lactonizing-like enzyme | Mandelate racemase/muconate lactonizing-like enzyme | MR_MLE-like_enzyme | 9 |
IPR053671 | 53,671 | Pilus tip thioester-containing adhesin | Pilus_tip_adhesin | Family | 28 | true | false | This family of proteins includes adhesins located at the tip of bacterial pili. They play a crucial role in bacterial adherence to host cell surfaces by forming covalent bonds with target molecules. The reactive thioester bonds present in these proteins suggest a mechanism for binding, potentially to lysine residues or... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033396"
] | [
"Pilus_tip_adhesin"
] | [
28
] | 1 | [] | [] | [] | 0 | [
"2xi9",
"2xic",
"2xid",
"4bug"
] | 4 | [
"PUB00105068"
] | [
"18928376"
] | [
"Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Streptococcus"
] | [
28
] | 1 | [] | [] | 0 | true | Family | Pilus tip thioester-containing adhesin | Pilus tip thioester-containing adhesin | Pilus_tip_adhesin | 2 |
IPR053672 | 53,672 | Type IV major pilin | Type_IV_major_pilin | Family | 29 | true | false | This family of proteins includes major components of type IV pili, which are filamentous structures on the surface of bacterial cells. These proteins are essential for social gliding motility, a process that involves the extension and retraction of pili to enable cell movement. The pilus assembly is orchestrated by a t... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041775"
] | [
"Type_IV_major_pilin"
] | [
29
] | 1 | [] | [] | [] | 0 | [
"8tj2"
] | 1 | [
"PUB00067658",
"PUB00152965"
] | [
"8748037",
"20444090"
] | [
"Genetic and functional evidence that Type IV pili are required for social gliding motility in Myxococcus xanthus.",
"PilA localization affects extracellular polysaccharide production and fruiting body formation in Myxococcus xanthus."
] | [
1995,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Cystobacterineae"
] | [
29
] | 1 | [] | [] | 0 | true | Family | Type IV major pilin | Type IV major pilin | Type_IV_major_pilin | 2 |
IPR053673 | 53,673 | Thiosulfate dehydrogenase small subunit | TQO_small_subunit | Family | 25 | true | false | This family of proteins includes small subunits of thiosulfate dehydrogenase [quinone], which are involved in the sulfur oxidation process. These proteins are believed to facilitate the transfer of electrons from sulfur compounds to the electron transport chain, ultimately reducing dioxygen. The electron transfer is me... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041178"
] | [
"TQO_small_subunit"
] | [
25
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015233"
] | [
"15306018"
] | [
"Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
25
] | 1 | [] | [] | 0 | true | Family | Thiosulfate dehydrogenase small subunit | Thiosulfate dehydrogenase small subunit | TQO_small_subunit | 5 |
IPR053674 | 53,674 | Plant RLCK Uridylyltransferase | RLCK_Uridylyltransferase | Family | 23 | true | false | This family of proteins includes enzymes that exhibit uridylyltransferase activity, which is implicated in both virulence and avirulence interactions with host plants. These proteins are capable of modifying host receptor-like cytoplasmic protein kinases (RLCKs) by uridylylation, affecting the host's immune signaling p... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041381"
] | [
"RLCK_Uridylyltransferase"
] | [
23
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106343",
"PUB00106365",
"PUB00106366"
] | [
"19849782",
"17951377",
"23951354"
] | [
"The type III effectors of Xanthomonas.",
"AvrAC(Xcc8004), a type III effector with a leucine-rich repeat domain from Xanthomonas campestris pathovar campestris confers avirulence in vascular tissues of Arabidopsis thaliana ecotype Col-0.",
"xopAC-triggered immunity against Xanthomonas depends on Arabidopsis re... | [
2009,
2008,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
23
] | 1 | [] | [] | 0 | true | Family | Plant RLCK Uridylyltransferase | Plant RLCK Uridylyltransferase | RLCK_Uridylyltransferase | 8 |
IPR053675 | 53,675 | Glucosamine-6-phosphate deaminase | GlcN6P_deaminase | Family | 18 | true | false | This family of proteins includes enzymes that are responsible for the reversible isomerization-deamination of glucosamine 6-phosphate into fructose 6-phosphate and ammonium ion. These enzymes play a crucial role in the metabolic pathway of chitin degradation, which is an important process for the recycling of nitrogen ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041128"
] | [
"GlcN6P_deaminase"
] | [
18
] | 1 | [] | [] | [] | 0 | [
"2cb0",
"2dec",
"2df8",
"2e5f"
] | 4 | [
"PUB00106187"
] | [
"16199574"
] | [
"Characterization of a novel glucosamine-6-phosphate deaminase from a hyperthermophilic archaeon."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Thermococcaceae"
] | [
18
] | 1 | [] | [] | 0 | true | Family | Glucosamine-6-phosphate deaminase | Glucosamine-6-phosphate deaminase | GlcN6P_deaminase | 6 |
IPR053676 | 53,676 | Trans-sulfuration enzyme-like | Trans-sulfuration_enzyme-like | Family | 12 | true | false | This family of proteins includes enzymes that are involved in amino acid racemization and trans-sulfuration processes. They are capable of catalyzing the conversion of L-alanine to D-alanine and L-glutamate to D-glutamate, which are crucial for peptidoglycan synthesis in certain organisms lacking the canonical genes fo... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041088"
] | [
"Trans-sulfuration_enzyme-like"
] | [
12
] | 1 | [] | [] | [] | 0 | [
"9iz5"
] | 1 | [
"PUB00106169",
"PUB00106170"
] | [
"23637642",
"28640457"
] | [
"The genome organization of Thermotoga maritima reflects its lifestyle.",
"Primordial-like enzymes from bacteria with reduced genomes."
] | [
2013,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
12
] | 1 | [] | [] | 0 | true | Family | Trans-sulfuration enzyme-like | Trans-sulfuration enzyme-like | Trans-sulfuration_enzyme-like | 3 |
IPR053678 | 53,678 | Autotransporter Adhesin | Autotransporter_Adhesin | Family | 23 | true | false | This family of proteins includes autotransporter adhesins that play a crucial role in bacterial pathogenesis. Members of this family are involved in mediating bacterial attachment to a wide range of host cells, which is a key step in the infection process. These proteins are known for their ability to promote bacterial... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033176"
] | [
"Autotransporter_Adhesin"
] | [
23
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
23
] | 1 | [] | [] | 0 | true | Family | Autotransporter Adhesin | Autotransporter Adhesin | Autotransporter_Adhesin | 7 |
IPR053679 | 53,679 | DadA oxidoreductase | DadA_oxidoreductase | Family | 19 | true | false | This family of proteins includes enzymes that are primarily involved in the oxidation of D-proline to Δ1-pyrroline-2-carboxylate. Members of this family exhibit oxidoreductase activity, acting on the CH-NH2 group of donors with oxygen as the acceptor. While D-proline is the preferred substrate, these enzymes are also c... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040813"
] | [
"DadA_oxidoreductase"
] | [
19
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105986",
"PUB00105987"
] | [
"11823469",
"18558115"
] | [
"Dye-linked D-proline dehydrogenase from hyperthermophilic archaeon Pyrobaculum islandicum is a novel FAD-dependent amino acid dehydrogenase.",
"Development of a D-amino acids electrochemical sensor based on immobilization of thermostable D-proline dehydrogenase within agar gel membrane."
] | [
2002,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Thermoproteaceae"
] | [
19
] | 1 | [] | [] | 0 | true | Family | DadA oxidoreductase | DadA oxidoreductase | DadA_oxidoreductase | 8 |
IPR053682 | 53,682 | Damage-control phosphatase | Damage-ctrl_phosphatase | Family | 12 | true | false | This family of proteins includes metal-dependent phosphatases that are thought to play a role in damage control by hydrolyzing oxidatively damaged purine nucleotides or their biosynthetic intermediates. Members of this family are characterized by specific conserved motifs that are critical for their function. These mot... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041594"
] | [
"Damage-ctrl_phosphatase"
] | [
12
] | 1 | [] | [] | [] | 0 | [
"2ffj"
] | 1 | [
"PUB00088733"
] | [
"27322068"
] | [
"A family of metal-dependent phosphatases implicated in metabolite damage-control."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
12
] | 1 | [] | [] | 0 | true | Family | Damage-control phosphatase | Damage-control phosphatase | Damage-ctrl_phosphatase | 7 |
IPR053683 | 53,683 | S-layer A-like | SlaA-like | Family | 13 | true | false | This family of proteins includes S-layer large proteins that are likely to contribute to the formation of a highly ordered outer sheath, which may be involved in protecting the cell from environmental factors and in mediating cell adhesion to surfaces. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040787"
] | [
"SlaA-like"
] | [
13
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105960"
] | [
"19522740"
] | [
"Acidianus, Sulfolobus and Metallosphaera surface layers: structure, composition and gene expression."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
13
] | 1 | [] | [] | 0 | true | Family | S-layer A-like | S-layer A-like | SlaA-like | 1 |
IPR053684 | 53,684 | Arsenate respiratory reductase iron-sulfur subunit | ArrB_iron-sulfur_subunit | Family | 16 | true | false | This family of proteins includes subunits that are part of the arsenate respiratory reductase complex, which is involved in the reduction of arsenate to arsenite, a process with implications for energy production and detoxification pathways. Members of this family are likely responsible for electron transfer within the... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041715"
] | [
"ArrB_iron-sulfur_subunit"
] | [
16
] | 1 | [] | [] | [] | 0 | [
"6cz7",
"6cz8",
"6cz9",
"6cza"
] | 4 | [
"PUB00152887",
"PUB00152888"
] | [
"17951391",
"30104376"
] | [
"Characterization of the arsenate respiratory reductase from Shewanella sp. strain ANA-3.",
"Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations."
] | [
2008,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Alteromonadales"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Arsenate respiratory reductase iron-sulfur subunit | Arsenate respiratory reductase iron-sulfur subunit | ArrB_iron-sulfur_subunit | 4 |
IPR053685 | 53,685 | L-isoleucine 3(1)-dioxygenase-like | Ile_3(1)-dioxygenase-like | Family | 18 | true | false | This family of proteins includes enzymes that are involved in the hydroxylation of specific amino acids. Members of this family primarily catalyze the conversion of L-isoleucine to L-4'-hydroxyisoleucine, a reaction that involves the addition of an oxygen atom to the C-4' position of the isoleucine side chain. This mod... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041274"
] | [
"Ile_3(1)-dioxygenase-like"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100360"
] | [
"23554367"
] | [
"A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
18
] | 1 | [] | [] | 0 | true | Family | L-isoleucine 3(1)-dioxygenase-like | L-isoleucine 3(1)-dioxygenase-like | Ile_3(1)-dioxygenase-like | 1 |
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