LiteFold/InterPro · Datasets at Hugging Face

IPR053686

53,686

Arsenate Respiratory Reductase Molybdopterin-Containing Subunit

Arr_molybdopterin_subunit

Family

17

true

false

This family of proteins includes arsenate respiratory reductase molybdopterin-containing subunits, such as ArrA. Members of this family are involved in the reduction of arsenate to arsenite, a process that is linked to energy production in prokaryotic organisms. The enzyme complex they form part of is typically located...

[]

0

[ "NCBIFAM" ]

[ "NF041714" ]

[ "Arr_molybdopterin_subunit" ]

[ 17 ]

1

[]

0

[ "6cz7", "6cz8", "6cz9", "6cza" ]

4

[ "PUB00152887", "PUB00152888" ]

[ "17951391", "30104376" ]

[ "Characterization of the arsenate respiratory reductase from Shewanella sp. strain ANA-3.", "Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations." ]

[ 2008, 2018 ]

2

[]

0

null

[ "Alteromonadales" ]

[ 17 ]

1

[]

0

true

Family

Arsenate Respiratory Reductase Molybdopterin-Containing Subunit

Arr_molybdopterin_subunit

5

IPR053688

53,688

Anti-sigma-F factor NrsF-like

Anti-sigma-F_NrsF-like

Family

9

true

false

This family of proteins includes anti-sigma factors that specifically interact with extracytoplasmic function (ECF) sigma factors such as sigma-F (SigF). Members of this family play a role in the cellular response to environmental stressors like chromate and cadmium. They maintain ECF sigma factors in an inactive state...

[]

0

[ "NCBIFAM" ]

[ "NF042994" ]

[ "Anti-sigma-F_NrsF-like" ]

[ 9 ]

1

[]

0

[]

0

[ "PUB00086036" ]

[ "22985357" ]

[ "Extracytoplasmic function (ECF) sigma factor σF is involved in Caulobacter crescentus response to heavy metal stress." ]

[ 2012 ]

1

[]

0

null

[ "Caulobacter" ]

[ 9 ]

1

[]

0

true

Family

Anti-sigma-F factor NrsF-like

Anti-sigma-F_NrsF-like

1

IPR053689

53,689

Archaeal Glycosyltransferase 16-like

AGL16-like

Family

12

true

false

This family of proteins includes glycosyltransferases that are involved in the final step of N-glycan biosynthesis. Members of this family are characterized by their enzymatic activity, which involves the transfer of sugar moieties to specific acceptor molecules, thus playing a crucial role in the formation of glycopro...

[]

0

[ "NCBIFAM" ]

[ "NF041010" ]

[ "AGL16-like" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00106128" ]

[ "23475978" ]

[ "Agl16, a thermophilic glycosyltransferase mediating the last step of N-Glycan biosynthesis in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius." ]

[ 2013 ]

1

[]

0

null

[ "Sulfolobaceae" ]

[ 12 ]

1

[]

0

true

Family

Archaeal Glycosyltransferase 16-like

AGL16-like

7

IPR053690

53,690

L-rhamnose 1-dehydrogenase (NADP(+))

L-rhamnose_1-dehydrogenase

Family

6

true

false

This family of proteins is involved in the catabolism of L-rhamnose, a sugar commonly found in plant cell walls. Members of this family function as enzymes that catalyze the first step in the non-phosphorylated metabolic pathway of L-rhamnose degradation. Specifically, they oxidize L-rhamnose to produce L-rhamnono-1,4-...

[]

0

[ "NCBIFAM" ]

[ "NF041159" ]

[ "L-rhamnose_1-dehydrogenase" ]

[ 6 ]

1

[]

0

[]

0

[ "PUB00106210" ]

[ "22481639" ]

[ "Characterization of NADP+-specific L-rhamnose dehydrogenase from the thermoacidophilic Archaeon Thermoplasma acidophilum." ]

[ 2012 ]

1

[]

0

null

[ "Thermoplasmatales" ]

[ 6 ]

1

[]

0

true

Family

L-rhamnose 1-dehydrogenase (NADP(+))

L-rhamnose_1-dehydrogenase

9

IPR053692

53,692

Glycosyl Hydrolase 2

GH2

Family

7

true

false

This family of proteins includes enzymes that catalyze the hydrolysis of beta-galactosides into monosaccharides. Members of this family are characterized by their ability to break down lactose into glucose and galactose, a critical step in the metabolism of this sugar in organisms that can digest lactose. These enzymes...

[]

0

[ "NCBIFAM" ]

[ "NF041100" ]

[ "GH2" ]

[ 7 ]

1

[]

0

[ "6s6z", "6sd0" ]

2

[ "PUB00106174", "PUB00106175" ]

[ "8088532", "9741105" ]

[ "Identification and sequencing of the Thermotoga maritima lacZ gene, part of a divergently transcribed operon.", "Properties of an alpha-galactosidase, and structure of its gene galA, within an alpha-and beta-galactoside utilization gene cluster of the hyperthermophilic bacterium Thermotoga maritima." ]

[ 1994, 1998 ]

2

[]

0

null

[ "Thermotogales" ]

[ 7 ]

1

[]

0

true

Family

Glycosyl Hydrolase 2

GH2

8

IPR053693

53,693

DnaJ-like chaperone

DnaJ-like_chaperone

Family

12

true

false

This family of proteins includes molecular chaperones that are part of the DnaJ, or Hsp40, family. They are characterized by the presence of a J-domain and play a crucial role in the heat shock response. These proteins typically function by stimulating the ATPase activity of Hsp70s, which are another type of heat shock...

[]

0

[ "NCBIFAM" ]

[ "NF037946" ]

[ "DnaJ-like_chaperone" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00062401", "PUB00105478" ]

[ "19183275", "21631602" ]

[ "Mycoplasma pneumoniae J-domain protein required for terminal organelle function.", "Loss of co-chaperone TopJ impacts adhesin P1 presentation and terminal organelle maturation in Mycoplasma pneumoniae." ]

[ 2009, 2011 ]

2

[]

0

null

[ "Mycoplasmatota" ]

[ 12 ]

1

[]

0

true

Family

DnaJ-like chaperone

DnaJ-like_chaperone

4

IPR053694

53,694

S-layer large protein

S-layer_large

Family

8

true

false

This family of proteins is involved in the formation of the highly ordered outer sheath of certain archaeal cells. Members of this family are characterized by their large size and are thought to play a role in providing structural support and protection, potentially contributing to the cell's shape and integrity under ...

[]

0

[ "NCBIFAM" ]

[ "NF041073" ]

[ "S-layer_large" ]

[ 8 ]

1

[]

0

[ "7zcx", "8an2", "8an3", "8qox", "8qp0" ]

5

[ "PUB00106156", "PUB00106157" ]

[ "16391651", "20936123" ]

[ "Molecular organization of selected prokaryotic S-layer proteins.", "The S-layer glycoprotein of the crenarchaeote Sulfolobus acidocaldarius is glycosylated at multiple sites with chitobiose-linked N-glycans." ]

[ 2005, 2010 ]

2

[]

0

null

[ "Sulfolobaceae" ]

[ 8 ]

1

[]

0

true

Family

S-layer large protein

S-layer_large

9

IPR053695

53,695

Abortive phage resistance AbiGi-like

AbiGi-like

Family

10

true

false

This family of proteins is involved in providing resistance to bacterial phages. The resistance mechanism is characterized by abortive infection, which is believed to function by disrupting the synthesis of phage RNA. The proteins in this family do not target the synthesis of phage DNA, indicating a specific interactio...

[]

0

[ "NCBIFAM" ]

[ "NF042957" ]

[ "AbiGi-like" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00008147", "PUB00152280" ]

[ "8795193", "9872803" ]

[ "AbiG, a genotypically novel abortive infection mechanism encoded by plasmid pCI750 of Lactococcus lactis subsp. cremoris UC653.", "Expression, regulation, and mode of action of the AbiG abortive infection system of lactococcus lactis subsp. cremoris UC653" ]

[ 1996, 1999 ]

2

[]

0

null

[ "Streptococcaceae" ]

[ 10 ]

1

[]

0

true

Family

Abortive phage resistance AbiGi-like

AbiGi-like

5

IPR053696

53,696

Sulfolobales S-layer anchor

SlaB_anchor

Family

7

true

false

This family of proteins is involved in the formation of the S-layer, a part of the cell envelope found in Sulfolobales archaea. Members of this family are believed to play a role in anchoring the S-layer complex to the cell membrane, which is crucial for maintaining cell shape and protecting the cell from its environme...

[]

0

[ "NCBIFAM" ]

[ "NF040788" ]

[ "SlaB_anchor" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00105960" ]

[ "19522740" ]

[ "Acidianus, Sulfolobus and Metallosphaera surface layers: structure, composition and gene expression." ]

[ 2009 ]

1

[]

0

null

[ "Metallosphaera" ]

[ 7 ]

1

[]

0

true

Family

Sulfolobales S-layer anchor

SlaB_anchor

9

IPR053697

53,697

Isocitrate/Homoisocitrate Dehydrogenase

ICDH/HICDH

Family

5

true

false

This family of proteins includes enzymes that are involved in the oxidative decarboxylation of isocitrate to 2-oxoglutarate and homoisocitrate to 2-oxoadipate. They play a crucial role in central metabolic pathways, such as the tricarboxylic acid (TCA) cycle and the lysine biosynthesis pathway. These enzymes exhibit a ...

[]

0

[ "NCBIFAM" ]

[ "NF040855" ]

[ "ICDH/HICDH" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00106026" ]

[ "15845397" ]

[ "Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase." ]

[ 2005 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 5 ]

1

[]

0

true

Family

Isocitrate/Homoisocitrate Dehydrogenase

ICDH/HICDH

7

IPR053698

53,698

Acyl-CoA synthetase (ADP-forming) alpha/beta

Acyl-CoA_synthetase_A/B

Family

6

true

false

This family of proteins is involved in the reversible conversion of various acids into their corresponding acyl-CoA esters, with a preference for aryl acids such as indoleacetate and phenylacetate over acetate. These enzymes are key in the degradation pathway of aryl-CoA esters, converting them back to the respective a...

[]

0

[ "NCBIFAM" ]

[ "NF045494" ]

[ "Acyl-CoA_synthetase_A/B" ]

[ 6 ]

1

[]

0

[]

0

[ "PUB00094637" ]

[ "11790732" ]

[ "Novel type of ADP-forming acetyl coenzyme A synthetase in hyperthermophilic archaea: heterologous expression and characterization of isoenzymes from the sulfate reducer Archaeoglobus fulgidus and the methanogen Methanococcus jannaschii." ]

[ 2002 ]

1

[]

0

null

[ "Archaeoglobus" ]

[ 6 ]

1

[]

0

true

Family

Acyl-CoA synthetase (ADP-forming) alpha/beta

Acyl-CoA_synthetase_A/B

9

IPR053699

53,699

Dapdiamide Synthase

Dapdiamide_Synthase

Family

7

true

false

This family of proteins is involved in the biosynthesis of dapdiamide antibiotics. Members of this family catalyze the ligation of N-beta-fumaramoyl-DAP with branched-chain amino acids such as valine, isoleucine, or leucine to produce dapdiamides A, B, or C. Additionally, these enzymes can catalyze the formation of dap...

[]

0

[ "NCBIFAM" ]

[ "NF041595" ]

[ "Dapdiamide_Synthase" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00151373" ]

[ "19807062" ]

[ "The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics." ]

[ 2009 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 7 ]

1

[]

0

true

Family

Dapdiamide Synthase

Dapdiamide_Synthase

9

IPR053700

53,700

Glycosyl Hydrolase 39

GH39

Family

5

true

false

This family of proteins includes enzymes with alpha-rhamnosidase activity, specifically involved in the degradation of ulvan, a major polysaccharide found in the cell walls of green seaweed. Members of this family are characterized by their ability to cleave alpha-1,4-L-rhamnosidic linkages in ulvan. The enzymatic acti...

[]

0

[ "NCBIFAM" ]

[ "NF042992" ]

[ "GH39" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00093668" ]

[ "31285597" ]

[ "A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan." ]

[ 2019 ]

1

[]

0

null

[ "Flavobacteriaceae" ]

[ 5 ]

1

[]

0

true

Family

Glycosyl Hydrolase 39

GH39

3

IPR053701

53,701

L-lysine 4-chlorinase BesD

BesD

Family

11

false

This entry represents a very small family of proteins which includes L-lysine 4-chlorinase BesD, a protein involved in the biosynthesis of terminal alkyne-containing amino acids such as L-propargylglycine (Pra) and L-beta-ethynylserine, that are produced as antibiotics by S.cattleya [ ].

[ "GO:0062147" ]

[ "L-lysine 4-chlorinase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF042920" ]

[ "Lys_halognase_BesD" ]

[ 11 ]

1

[]

0

[ "6nie" ]

1

[ "PUB00093050" ]

[ "30867596" ]

[ "Discovery of a pathway for terminal-alkyne amino acid biosynthesis." ]

[ 2019 ]

1

[ "IPR056470" ]

[]

1

0

1

[ "Streptomycetaceae" ]

[ 11 ]

1

[]

0

true

Family

L-lysine 4-chlorinase BesD

BesD

8

IPR053702

53,702

4-chloro-allylglycine synthase

BesC

Family

11

true

This entry represents 4-chloro-allylglycine synthase in streptomyces. Members of this family are enzymes that catalyse the oxidative cleavage of specific lysine derivatives to produce amino acids with terminal alkyne groups. These reactions result in the formation of compounds such as L-propargylglycine and L-beta-ethy...

[]

0

[ "NCBIFAM" ]

[ "NF042919" ]

[ "Alkyne_AA_Synthase" ]

[ 11 ]

1

[]

0

[ "7twa" ]

1

[ "PUB00093050" ]

[ "30867596" ]

[ "Discovery of a pathway for terminal-alkyne amino acid biosynthesis." ]

[ 2019 ]

1

[ "IPR039068" ]

[]

1

0

1

[ "Streptomycetaceae" ]

[ 11 ]

1

[]

0

true

Family

4-chloro-allylglycine synthase

BesC

8

IPR053703

53,703

Abortive phage resistance AbiGii-like

AbiGii-like

Family

5

true

false

This family of proteins is involved in providing resistance to bacterial phages. Members of this family are known to disrupt the process of phage infection in a manner that results in the premature termination of the infection cycle. The mechanism of action appears to target the synthesis of phage RNA, thereby preventi...

[]

0

[ "NCBIFAM" ]

[ "NF042958" ]

[ "AbiGii-like" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00008147", "PUB00152280" ]

[ "8795193", "9872803" ]

[ "AbiG, a genotypically novel abortive infection mechanism encoded by plasmid pCI750 of Lactococcus lactis subsp. cremoris UC653.", "Expression, regulation, and mode of action of the AbiG abortive infection system of lactococcus lactis subsp. cremoris UC653" ]

[ 1996, 1999 ]

2

[]

0

null

[ "Lactococcus" ]

[ 5 ]

1

[]

0

true

Family

Abortive phage resistance AbiGii-like

AbiGii-like

5

IPR053704

53,704

Sarcosine/dimethylglycine N-methyltransferase

SDMT

Family

4

true

false

This family of proteins includes enzymes that function as methyltransferases, specifically catalyzing the transfer of methyl groups from S-adenosylmethionine to sarcosine and dimethylglycine, resulting in the production of dimethylglycine and betaine, respectively. These enzymes exhibit strict substrate specificity for...

[]

0

[ "NCBIFAM" ]

[ "NF041675" ]

[ "SDMT" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00152980", "PUB00152981" ]

[ "10896953", "11319079" ]

[ "Extreme halophiles synthesize betaine from glycine by methylation.", "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase." ]

[ 2000, 2001 ]

2

[ "IPR050447" ]

[]

1

0

1

[ "Halorhodospira" ]

[ 4 ]

1

[]

0

true

Family

Sarcosine/dimethylglycine N-methyltransferase

SDMT

7

IPR053705

53,705

L-propargylglycine--L-glutamate ligase

LpgL-glutamate_ligase

Family

10

true

This family of proteins is involved in the biosynthesis of unique amino acids with terminal alkyne groups, which serve as antibiotics. These proteins catalyze the ATP-dependent formation of dipeptides by ligating L-propargylglycine with L-glutamate, resulting in L-gamma-glutamyl-L-propargylglycine. The enzyme exhibits ...

[]

0

[ "NCBIFAM" ]

[ "NF042917" ]

[ "LpgL-glutamate_ligase" ]

[ 10 ]

1

[]

0

[ "8yi6" ]

1

[ "PUB00093050" ]

[ "30867596" ]

[ "Discovery of a pathway for terminal-alkyne amino acid biosynthesis." ]

[ 2019 ]

1

[]

0

null

[ "Streptomycetaceae" ]

[ 10 ]

1

[]

0

true

Family

L-propargylglycine--L-glutamate ligase

LpgL-glutamate_ligase

7

IPR053706

53,706

Acetophenone carboxylase alpha subunit-like

APC_alpha_subunit-like

Family

4

true

false

This family of proteins includes enzymes that are involved in the anaerobic catabolism of ethylbenzene, catalyzing the carboxylation of acetophenone to produce 3-oxo-3-phenylpropanoate, also known as benzoylacetate. Members of this family can also carboxylate propiophenone and 4-acetyl-pyridine, albeit at different rat...

[]

0

[ "NCBIFAM" ]

[ "NF042960" ]

[ "APC_alpha_subunit-like" ]

[ 4 ]

1

[]

0

[ "5l9w" ]

1

[ "PUB00062149", "PUB00153438", "PUB00153439" ]

[ "20047908", "10941798", "15687214" ]

[ "ATP-dependent carboxylation of acetophenone by a novel type of carboxylase.", "Anaerobic degradation of ethylbenzene and toluene in denitrifying strain EbN1 proceeds via independent substrate-induced pathways.", "Substrate-dependent regulation of anaerobic degradation pathways for toluene and ethylbenzene in a...

[ 2010, 1999, 2005 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 4 ]

1

[]

0

true

Family

Acetophenone carboxylase alpha subunit-like

APC_alpha_subunit-like

7

IPR053707

53,707

UPF0637 domain-containing protein

UPF0637_domain_sf

Homologous_superfamily

2,239

true

false

This superfamily of proteins is characterized by a shared domain architecture that suggests a potential role in various cellular processes. However, the specific functions of these proteins are not well-defined and may vary across different members of the superfamily. Research into individual family members is required...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.930.20" ]

[ "UPF0637_domain_sf" ]

[ 2239 ]

1

[]

0

[ "2a8e", "3mqz" ]

2

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2235, 1, 3 ]

3

[]

0

true

Homologous_superfamily

UPF0637 domain-containing protein

UPF0637_domain_sf

7

IPR053709

53,709

Eukaryotic Ribosomal Protein eS24

eRP_eS24_sf

Homologous_superfamily

8,078

true

false

This superfamily of proteins is involved in the structure and function of the ribosome, specifically the small ribosomal subunit. Members of this superfamily are essential for protein synthesis within the cell. They participate in the processing of precursor ribosomal RNA and the maturation of the 40S ribosomal subunit...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.70.3370" ]

[ "eRP_eS24_sf" ]

[ 8078 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-179933...

74

[ "3j16", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q"...

603

[]

0

[]

0

null

[ "Archaea", "Eukaryota", "Gammaproteobacteria", "ecological metagenomes" ]

[ 242, 7804, 3, 29 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 1, 5, 9, 1, 9, 16, 2, 2, 35 ]

12

true

Homologous_superfamily

Eukaryotic Ribosomal Protein eS24

eRP_eS24_sf

9

IPR053710

53,710

Arylamine N-acetyltransferase domain-containing protein

Arylamine_NAT_domain_sf

Homologous_superfamily

7,930

true

false

This superfamily of proteins is involved in the detoxification of various compounds, including drugs and plant-produced toxins. Members of this superfamily are characterized by their ability to transfer acetyl groups from acetyl-CoA to various substrates, a process known as acetylation. This modification can lead to th...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.2140.20" ]

[ "Arylamine_NAT_domain_sf" ]

[ 7930 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1", "2.3.1.5", "R-BTA-156582", "R-BTA-9753281", "R-GGA-156582", "R-GGA-9753281", "R-HSA-156582", "R-HSA-9753281", "R-MMU-156582", "R-MMU-9753281", "R-RNO-156582", "R-RNO-9753281" ]

[ "EC:2.3.1", "EC:2.3.1.5", "REACTOME:R-BTA-156582", "REACTOME:R-BTA-9753281", "REACTOME:R-GGA-156582", "REACTOME:R-GGA-9753281", "REACTOME:R-HSA-156582", "REACTOME:R-HSA-9753281", "REACTOME:R-MMU-156582", "REACTOME:R-MMU-9753281", "REACTOME:R-RNO-156582", "REACTOME:R-RNO-9753281" ]

12

[ "2ija", "2pfr", "2pqt", "3lnb", "4dmo", "7qi3", "8btm", "8oom", "8osv", "8osz", "8ot2" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 39, 2532, 5294, 49, 16 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 12, 44, 9, 1, 12 ]

5

true

Homologous_superfamily

Arylamine N-acetyltransferase domain-containing protein

Arylamine_NAT_domain_sf

2

IPR053711

53,711

Lentiviral Vpx-associated factor

Lentiviral_Vpx_assoc_factor

Homologous_superfamily

662

true

false

This superfamily of proteins is involved in the viral infection process of non-dividing cells. They facilitate the nuclear translocation of the viral pre-integration complex, which is essential for the integration of viral DNA into the host genome. Additionally, these proteins interact with the host's ubiquitin-proteas...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.5.4730" ]

[ "Lentiviral_Vpx_assoc_factor" ]

[ 662 ]

1

[]

0

[ "4cc9", "4z8l", "5aja" ]

3

[]

0

[]

0

null

[ "Heliantheae alliance", "Lentivirus" ]

[ 2, 660 ]

2

[]

0

true

Homologous_superfamily

Lentiviral Vpx-associated factor

Lentiviral_Vpx_assoc_factor

3

IPR053712

53,712

Bacterial Cell Division Activator

Bac_CellDiv_Activator

Homologous_superfamily

4,029

true

false

This superfamily of proteins acts as activators of bacterial cell division. They are known to inhibit the GTPase activity of the FtsZ protein, which is a key regulator in the assembly of the bacterial cytoskeleton. By inhibiting FtsZ GTPase activity, these proteins promote the polymerization of FtsZ into protofilaments...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.10.250.790" ]

[ "Bac_CellDiv_Activator" ]

[ 4029 ]

1

[]

0

[ "2mmv", "3hnw" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured marine group II/III euryarchaeote KM3_76_C12" ]

[ 3974, 3, 51, 1 ]

4

[]

0

true

Homologous_superfamily

Bacterial Cell Division Activator

Bac_CellDiv_Activator

4

IPR053713

53,713

Bacterial Outer Membrane Channel Superfamily

Bact_OM_Channel_sf

Homologous_superfamily

5,481

true

false

This superfamily of proteins includes outer membrane channel proteins that facilitate the transport of specific solutes across the bacterial outer membrane. Members of this superfamily are involved in the uptake of compounds such as N-acetylneuraminic acid, small sugars, and oligogalacturonides, which are essential for...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.160.40" ]

[ "Bact_OM_Channel_sf" ]

[ 5481 ]

1

[]

0

[ "2f1c", "2iwv", "2iww", "2jqy", "2wjq", "2wjr", "2wvp", "2x9k", "4ctd", "4fqe", "4pr7", "5mwv", "6oqh", "7q5c", "8xua" ]

15

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Straboviridae", "metagenomes" ]

[ 5295, 168, 3, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Homologous_superfamily

Bacterial Outer Membrane Channel Superfamily

Bact_OM_Channel_sf

8

IPR053714

53,714

Isomerization and Racemization Enzyme Superfamily

Iso_Racemase_Enz_sf

Homologous_superfamily

21,824

true

false

This superfamily of proteins includes enzymes that catalyze isomerization and racemization reactions. Members of this superfamily are involved in the conversion of maleate to fumarate, a reaction that involves the cis-trans isomerization of a double bond. Other members are responsible for the racemization of hydantoins...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.40.50.12500" ]

[ "Iso_Racemase_Enz_sf" ]

[ 21824 ]

1

[]

0

[ "2vlb", "2xec", "2xed", "3dg9", "3dtv", "3eis", "3ip8", "3ixl", "3ixm", "3qvj", "3qvk", "3qvl", "4fq5", "4fq7", "4ix1", "5lfd", "5lg5" ]

17

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviridae environmental sample", "unclassified sequences" ]

[ 292, 18784, 2437, 1, 310 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Homologous_superfamily

Isomerization and Racemization Enzyme Superfamily

Iso_Racemase_Enz_sf

2

IPR053715

53,715

Glycosyl Hydrolase 4 Enzyme Superfamily

GH4_Enzyme_sf

Homologous_superfamily

5,728

true

false

This superfamily of proteins includes enzymes that catalyze the hydrolysis of glycosidic bonds in various oligosaccharides and polysaccharides. Members of this superfamily are characterized by their ability to act on alpha-linked sugar moieties, with specificities that include but are not limited to alpha-galactosidase...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.90.1820.10" ]

[ "GH4_Enzyme_sf" ]

[ 5728 ]

1

[ "EC" ]

[ "3.2.1" ]

[ "EC:3.2.1" ]

1

[ "1obb", "1vjt", "3fef", "3u95", "6kcx", "7br4", "7brf", "7ctd", "7ctl", "7ctm" ]

10

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 183, 5385, 22, 138 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Homologous_superfamily

Glycosyl Hydrolase 4 Enzyme Superfamily

GH4_Enzyme_sf

9

IPR053716

53,716

Flagellar assembly and chemotaxis effector

Flag_assembly_chemotaxis_eff

Homologous_superfamily

12,012

true

false

This superfamily of proteins includes components involved in bacterial flagellar assembly and chemotaxis. Members of this superfamily are implicated in the formation and function of the flagellum, a lash-like appendage that enables motility in various bacterial species. These proteins play a role in the response to che...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.287.1700" ]

[ "Flag_assembly_chemotaxis_eff" ]

[ 12012 ]

1

[]

0

[ "1u8x", "1yb5", "1zkp", "2ar7", "2bbw", "2byg", "2c2n", "2c9h", "2cjz", "2dfd", "2f8a", "2fne", "2fv8", "2g3y", "2g62", "2gl2", "2gx8", "2ht9", "2i0z", "2i9p", "2j1l", "2j8z", "2ksr", "2qq2", "2r4h", "2uxw", "2uyy", "2uz9", "2v40", "2w4o", "2wu6", "2wu7"...

517

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4, 11805, 64, 2, 137 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

Flagellar assembly and chemotaxis effector

Flag_assembly_chemotaxis_eff

5

IPR053718

53,718

Insecticidal knottin-like domain-containing protein

Insecticidal_knottin-like_sf

Homologous_superfamily

10

true

false

This superfamily of proteins includes members that exhibit insecticidal properties. They are characterized by their ability to inhibit insect voltage-gated sodium channels, leading to partial blockade of the channel pore. This action results in flaccid paralysis and eventual death when administered to certain insect la...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:4.10.40.60" ]

[ "Insecticidal_knottin-like_sf" ]

[ 10 ]

1

[]

0

[ "2mf3" ]

1

[]

0

[]

0

null

[ "Segestria florentina" ]

[ 10 ]

1

[]

0

true

Homologous_superfamily

Insecticidal knottin-like domain-containing protein

Insecticidal_knottin-like_sf

1

IPR053719

53,719

Lipogenesis and Microtubule Stabilization Superfamily

Lipogen_MT_Stabilize_sf

Homologous_superfamily

2,610

true

false

This superfamily of proteins is involved in the regulation of lipid metabolism, particularly lipogenesis. Members of this superfamily are known to up-regulate enzyme activity associated with the biosynthesis of various lipids, including triacylglycerol, diacylglycerol, and phospholipid. They are also implicated in the ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.10.140.1610" ]

[ "Lipogen_MT_Stabilize_sf" ]

[ 2610 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-200425", "R-HSA-200425", "R-HSA-9841922", "R-MMU-200425", "R-RNO-200425" ]

[ "REACTOME:R-DRE-200425", "REACTOME:R-HSA-200425", "REACTOME:R-HSA-9841922", "REACTOME:R-MMU-200425", "REACTOME:R-RNO-200425" ]

5

[ "3ont" ]

1

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 2610 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 2, 7, 7 ]

5

true

Homologous_superfamily

Lipogenesis and Microtubule Stabilization Superfamily

Lipogen_MT_Stabilize_sf

7

IPR053720

53,720

Proteasome Assembly Chaperone

Psm_Assembly_Chaperone

Homologous_superfamily

3,652

true

false

This superfamily of proteins is involved in the assembly and regulation of the 20S proteasome, a key component of the ubiquitin-proteasome system responsible for protein degradation. Members of this superfamily function as chaperones that facilitate the correct folding and assembly of proteasome subunits. They may work...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.230.90" ]

[ "Psm_Assembly_Chaperone" ]

[ 3652 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9907900", "R-DDI-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-SPO-9907900" ]

[ "REACTOME:R-BTA-9907900", "REACTOME:R-DDI-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-SPO-9907900" ]

5

[ "2z5b", "2z5c", "2z5e", "6jpt", "8qyj", "8tm3" ]

6

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3652 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 1, 1, 1, 2, 1, 7, 2, 1, 1, 14 ]

12

true

Homologous_superfamily

Proteasome Assembly Chaperone

Psm_Assembly_Chaperone

4

IPR053721

53,721

Fimbrial Adhesin Regulatory Protein

Fimbrial_Adhesin_Reg

Homologous_superfamily

2,171

true

false

This superfamily of proteins includes transcriptional regulators that modulate the expression of genes associated with the biosynthesis of various types of fimbriae and adhesins. These proteins are involved in both positive and negative regulation of gene transcription, with some acting as trans-acting factors. They pl...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.10.2690" ]

[ "Fimbrial_Adhesin_Reg" ]

[ 2171 ]

1

[]

0

[ "2n5g", "2w7n", "3m8j", "5ckt", "5clv", "5cm3", "7bbq", "7bca", "7bcb", "8qa9" ]

10

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Ignisphaera aggregans", "Viruses", "metagenomes", "plasmids" ]

[ 2130, 4, 3, 8, 12, 14 ]

6

[]

0

true

Homologous_superfamily

Fimbrial Adhesin Regulatory Protein

Fimbrial_Adhesin_Reg

1

IPR053722

53,722

Curli assembly CsgC/AgfC domain-containing protein

Curli_assembly_CsgC/AgfC

Homologous_superfamily

1,596

true

false

This superfamily of proteins is involved in the formation of extracellular fibrous structures known as thin aggregative fimbriae, which are important for cell adhesion and biofilm formation. The proteins facilitate the assembly of a major structural subunit, promoting the formation of these fibers through a process tha...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.2420" ]

[ "Curli_assembly_CsgC/AgfC" ]

[ 1596 ]

1

[]

0

[ "2n59", "2xsk", "2y2t", "2y2y" ]

4

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1590, 6 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

Curli assembly CsgC/AgfC domain-containing protein

Curli_assembly_CsgC/AgfC

2

IPR053723

53,723

Secretoglobin Domain-Containing

Secretoglobin_Domain_sf

Homologous_superfamily

639

true

false

This superfamily of proteins is characterized by their involvement in various biological processes, primarily related to the transport and sequestration of small hydrophobic molecules. Members of this superfamily are typically small, secreted proteins that can bind to a range of ligands, including hormones, pheromones,...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.920.50" ]

[ "Secretoglobin_Domain_sf" ]

[ 639 ]

1

[]

0

[ "1puo", "1zkr", "2ejn", "5vyf" ]

4

[]

0

[]

0

null

[ "Bilateria", "Pseudomonas fluorescens" ]

[ 638, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 49, 15 ]

3

true

Homologous_superfamily

Secretoglobin Domain-Containing

Secretoglobin_Domain_sf

4

IPR053724

53,724

Outer Membrane Peptidase A26

OMP_A26_sf

Homologous_superfamily

2,217

true

false

This superfamily of proteins includes outer membrane proteases with diverse functions, such as acting as receptors for bacteriophages, activating plasminogen in mammalian hosts, and cleaving various substrates including T7 RNA polymerase, ferric enterobactin receptor protein, and antimicrobial peptides. Members of this...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.128.90" ]

[ "OMP_A26_sf" ]

[ 2217 ]

1

[]

0

[ "1i78", "2x4m", "2x55", "2x56", "4dcb", "7xw0" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Nesevirus", "ecological metagenomes" ]

[ 2198, 2, 2, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Homologous_superfamily

Outer Membrane Peptidase A26

OMP_A26_sf

5

IPR053725

53,725

CRISPR-associated Cas5

CRISPR_Cas5_sf

Homologous_superfamily

196

true

false

This superfamily of proteins is involved in the CRISPR adaptive immune system, which provides a defense mechanism against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of this superfamily are associated with the processing of CRISPR clusters into CRISPR RNA (crRNA), w...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.70.3120" ]

[ "CRISPR_Cas5_sf" ]

[ 196 ]

1

[]

0

[ "4mjk", "7r21", "7r2k", "7tr6", "7tr8", "7tr9", "7tra", "9cp1", "9cp2", "9cp3", "9cro", "9crp", "9crq" ]

13

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Trypanosoma rangeli" ]

[ 171, 23, 2 ]

3

[]

0

true

Homologous_superfamily

CRISPR-associated Cas5

CRISPR_Cas5_sf

6

IPR053726

53,726

Bacterial Lectin Domain-Containing Protein

Bacterial_Lectin_Domain_sf

Homologous_superfamily

176

true

false

This superfamily of proteins includes bacterial lectins that exhibit specificity for high mannose N-glycans, recognizing the branched structures within these glycans. They do not interact with other types of N-glycans or monosaccharides. Members of this superfamily are involved in cell differentiation and may have role...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.128.450" ]

[ "Bacterial_Lectin_Domain_sf" ]

[ 176 ]

1

[]

0

[ "2mwh", "3obl", "3s5v", "3s5x", "3s60", "4fbo", "4fbr", "4fbv", "4gk9", "4gu8", "7dc0", "7dc4", "7umj", "9auq", "9b4v", "9b4w" ]

16

[]

0

[]

0

null

[ "Bacteria", "Solieriaceae" ]

[ 163, 13 ]

2

[]

0

true

Homologous_superfamily

Bacterial Lectin Domain-Containing Protein

Bacterial_Lectin_Domain_sf

1

IPR053727

53,727

HPA decarboxylase small subunit superfamily

HPA_decarboxylase_ss_sf

Homologous_superfamily

86

true

false

This superfamily of proteins is involved in the enzymatic decarboxylation of phenylacetates, particularly those with a hydroxyl group in the para position. The proteins function as components of a larger enzymatic complex known as HPA decarboxylase, which plays a crucial role in the catabolism of aromatic amino acids, ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.20.70.100" ]

[ "HPA_decarboxylase_ss_sf" ]

[ 86 ]

1

[ "EC", "METACYC" ]

[ "4.1.1.83", "PWY-7514" ]

[ "EC:4.1.1.83", "METACYC:PWY-7514" ]

2

[ "2y8n", "2yaj" ]

2

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 83, 3 ]

2

[]

0

true

Homologous_superfamily

HPA decarboxylase small subunit superfamily

HPA_decarboxylase_ss_sf

5

IPR053728

53,728

Alginate Permeability Channel-forming

Alginate_Permeability_Chnl

Homologous_superfamily

4,255

true

false

This superfamily of proteins is involved in the transport of alginate, a biopolymer produced by certain bacteria. Members of this superfamily are characterized by their ability to form channels in the bacterial membrane that facilitate the permeation of alginate. These channels are distinct from classical porins as the...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.160.100" ]

[ "Alginate_Permeability_Chnl" ]

[ 4255 ]

1

[]

0

[ "3rbh", "4afk", "4azl", "4b61", "4xnk", "4xnl", "5d5d", "5iyu", "7acg", "8pz4", "8q2o", "8rqp" ]

12

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4198, 7, 50 ]

3

[]

0

true

Homologous_superfamily

Alginate Permeability Channel-forming

Alginate_Permeability_Chnl

8

IPR053730

53,730

Multidrug Efflux Pump Accessory AcrZ

MEP_Accessory_AcrZ

Homologous_superfamily

1,051

true

false

This superfamily of proteins is involved in the efflux of a broad range of substrates across the cell membrane, contributing to multidrug resistance. Members of this superfamily interact with components of a protein complex that actively transports various compounds out of the cell. The presence of these proteins is es...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.10.250.2480" ]

[ "MEP_Accessory_AcrZ" ]

[ 1051 ]

1

[]

0

[ "4c48", "4cdi", "5nc5", "5ng5", "5o66", "6sgr", "6sgs", "9v53" ]

8

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1050, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

Multidrug Efflux Pump Accessory AcrZ

MEP_Accessory_AcrZ

4

IPR053731

53,731

Fimbrial Structure-Associated Virulence Factor

Fimbrial_Virulence_Factor

Homologous_superfamily

32

true

false

This superfamily of proteins is involved in the formation of fibrillar structures that are components of fimbriae, which are hair-like appendages on the surface of bacteria. These structures are implicated in bacterial virulence as they play a crucial role in the adherence to host cells, colonization, and evasion of th...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.3590" ]

[ "Fimbrial_Virulence_Factor" ]

[ 32 ]

1

[]

0

[ "4f8l", "4f8n", "4f8o", "4f8p", "5ln4", "5ln8", "5lnd", "5lo7" ]

8

[]

0

[]

0

null

[ "Bacteria" ]

[ 32 ]

1

[]

0

true

Homologous_superfamily

Fimbrial Structure-Associated Virulence Factor

Fimbrial_Virulence_Factor

5

IPR053732

53,732

Fimbrial Assembly Component

Fimbrial_Assembly_Comp

Homologous_superfamily

22

true

false

This superfamily of proteins includes components that are integral to the structure of fimbriae, also known as pili. These hair-like appendages extend from the bacterial cell surface and are critical for adherence to host epithelial cells, facilitating colonization and persistence within host tissues. The superfamilies...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.3480" ]

[ "Fimbrial_Assembly_Comp" ]

[ 22 ]

1

[]

0

[ "4b9g", "4b9i", "4b9j" ]

3

[]

0

[]

0

null

[ "Bacteria" ]

[ 22 ]

1

[]

0

true

Homologous_superfamily

Fimbrial Assembly Component

Fimbrial_Assembly_Comp

3

IPR053733

53,733

Heme Transport and Utilization Superfamily

Heme_Transport_Util_sf

Homologous_superfamily

6,167

true

false

This superfamily of proteins is involved in the transport and management of heme, an essential cofactor in various biological processes. Members of this superfamily are responsible for binding heme and facilitating its transfer to other proteins, such as heme-degrading enzymes. They play a crucial role in the binding-p...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.40.1570.10", "SSF144064" ]

[ "Heme_Transport_Util_sf", "" ]

[ 5932, 6110 ]

2

[]

0

[ "1u9t", "2hqv", "2j0p", "2j0r", "2ovi", "2ph0", "3fm2", "4cdp", "4imh", "4mf9", "4mgf", "5exv", "6u9j", "7qxv" ]

14

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrososphaerota", "unclassified sequences" ]

[ 5942, 121, 51, 53 ]

4

[]

0

true

Homologous_superfamily

Heme Transport and Utilization Superfamily

Heme_Transport_Util_sf

1

IPR053734

53,734

Bacteriophage Head-Tail Connecting Superfamily

Phage_Head-Tail_Connect_sf

Homologous_superfamily

1,867

true

false

This superfamily of proteins is involved in the assembly of viral particles, specifically in the process of connecting the head and tail components of bacteriophages. The proteins function at the final stage of morphogenesis, ensuring the proper attachment of the DNA-containing head to the pre-assembled tail structure....

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.10.180" ]

[ "Phage_Head-Tail_Connect_sf" ]

[ 1867 ]

1

[]

0

[ "1k0h", "2kx4", "8gtf", "8k37", "8xow", "8xpm", "8xqb" ]

7

[]

0

[]

0

null

[ "Bacteria", "Mycena chlorophos", "Viruses", "metagenomes" ]

[ 1818, 1, 39, 9 ]

4

[]

0

true

Homologous_superfamily

Bacteriophage Head-Tail Connecting Superfamily

Phage_Head-Tail_Connect_sf

8

IPR053735

53,735

Type III TA system endoribonuclease

Type_III_TA_endoRNase

Homologous_superfamily

896

true

false

This superfamily of proteins includes endoribonucleases that function as toxic components within type III toxin-antitoxin (TA) systems. These proteins typically cleave specific RNA sequences, leading to growth inhibition in a bacteriostatic manner without causing cell lysis. The endoribonuclease activity is neutralized...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.10.129.130" ]

[ "Type_III_TA_endoRNase" ]

[ 896 ]

1

[]

0

[ "2xd0", "2xdb", "2xdd", "4ato", "4glk", "4rmo", "7d8o" ]

7

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 868, 12, 9, 7 ]

4

[]

0

true

Homologous_superfamily

Type III TA system endoribonuclease

Type_III_TA_endoRNase

1

IPR053736

53,736

Metallocarboxypeptidase Inhibitor Domain-containing Protein

MCP_Inhibitor_Domain_sf

Homologous_superfamily

4

true

false

This superfamily of proteins consists of inhibitors that specifically target metallocarboxypeptidases, a type of metalloprotease. Members of this superfamily are capable of inhibiting a range of metallocarboxypeptidases from different species, including bovine CPA1, human CPA1, CPA2, CPA4, CPB1, CPB2, and porcine CPB1....

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.10.25.90" ]

[ "MCP_Inhibitor_Domain_sf" ]

[ 4 ]

1

[]

0

[ "4a94", "5mrv" ]

2

[]

0

[]

0

null

[ "Nerita" ]

[ 4 ]

1

[]

0

true

Homologous_superfamily

Metallocarboxypeptidase Inhibitor Domain-containing Protein

MCP_Inhibitor_Domain_sf

1

IPR053738

53,738

Lambda phage major capsid assembly

Lambda_capsid_assembly

Homologous_superfamily

2,211

true

false

This superfamily of proteins is involved in the assembly of icosahedral capsids, which are geometric structures composed of proteins that encapsulate the genetic material of certain viruses. Members of this superfamily are characterized by their structural role in forming the protective shell that is critical for the s...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.90.1690.10" ]

[ "Lambda_capsid_assembly" ]

[ 2211 ]

1

[]

0

[ "3bjq" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 1762, 12, 3, 338, 96 ]

5

[]

0

true

Homologous_superfamily

Lambda phage major capsid assembly

Lambda_capsid_assembly

5

IPR053739

53,739

Bacteriocin Immunity Domain-containing Protein

Bact_Immunity_Domain_sf

Homologous_superfamily

580

true

false

This superfamily of proteins includes members that are involved in providing immunity to certain types of bacteriocins, which are antimicrobial peptides produced by bacteria. The proteins within this superfamily are responsible for protecting host bacterial cells from the lethal action of these peptides. By binding to ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.1440.140" ]

[ "Bact_Immunity_Domain_sf" ]

[ 580 ]

1

[]

0

[ "2ip6", "2k19", "2zrr" ]

3

[]

0

[]

0

null

[ "Bacteria" ]

[ 580 ]

1

[]

0

true

Homologous_superfamily

Bacteriocin Immunity Domain-containing Protein

Bact_Immunity_Domain_sf

3

IPR053740

53,740

Type III Secretion System Pilotin

T3SS_Pilotin

Homologous_superfamily

145

true

false

This superfamily of proteins is involved in the assembly and operation of the type III secretion system (T3SS), a complex bacterial apparatus that facilitates the injection of effector proteins into eukaryotic host cells. Members of this superfamily function as pilot proteins, essential for the correct placement and st...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.2990" ]

[ "T3SS_Pilotin" ]

[ 145 ]

1

[]

0

[ "2yjl" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 145 ]

1

[]

0

true

Homologous_superfamily

Type III Secretion System Pilotin

T3SS_Pilotin

3

IPR053741

53,741

Serine and fungal protease inhibitor

Ser_Fungal_Prot_Inhib_sf

Homologous_superfamily

242

true

false

This superfamily of proteins includes members that function as inhibitors of various serine proteases, such as trypsin, and fungal proteases. These proteins exhibit specificity in their inhibitory activity, as they do not inhibit a range of other proteases, including chymotrypsin, subtilisin Carlsberg, proteinase K, po...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.10.80.20" ]

[ "Ser_Fungal_Prot_Inhib_sf" ]

[ 242 ]

1

[]

0

[ "3bt4" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 239 ]

2

[]

0

true

Homologous_superfamily

Serine and fungal protease inhibitor

Ser_Fungal_Prot_Inhib_sf

3

IPR053742

53,742

Fungal Immunomodulatory Lectin

Fungal_ImmunoLectin_sf

Homologous_superfamily

126

true

false

This superfamily of proteins includes lectins that have a specificity for complex cell-surface carbohydrates and exhibit immunomodulatory activities. Members of this superfamily can stimulate lymphocyte mitogenesis, suppress systemic anaphylaxis reactions and edema, and enhance the transcription of cytokines such as IL...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.1790" ]

[ "Fungal_ImmunoLectin_sf" ]

[ 126 ]

1

[]

0

[ "1osy", "3f3h", "3kcw", "7mjr", "7wdl", "7wdm", "8go5", "8go6", "8go7" ]

9

[]

0

[]

0

null

[ "Bacillota", "Dikarya" ]

[ 49, 77 ]

2

[]

0

true

Homologous_superfamily

Fungal Immunomodulatory Lectin

Fungal_ImmunoLectin_sf

4

IPR053743

53,743

CRISPR system Cmr7 complex component

CRISPR_Cmr7_comp

Homologous_superfamily

14

true

false

This superfamily of proteins is involved in the CRISPR adaptive immune system, which provides a defense mechanism against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of this superfamily are associated with the processing of CRISPR RNA (crRNA) and the subsequent targ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.120.1670" ]

[ "CRISPR_Cmr7_comp" ]

[ 14 ]

1

[]

0

[ "2x5q", "2xvo", "6s6b", "6s8b", "6s8e", "6s91", "6sh8", "6shb", "6sic" ]

9

[]

0

[]

0

null

[ "Sulfolobaceae" ]

[ 14 ]

1

[]

0

true

Homologous_superfamily

CRISPR system Cmr7 complex component

CRISPR_Cmr7_comp

4

IPR053744

53,744

UDG Inhibitor phi29likevirus

UDG_Inhib_phi29likevirus

Homologous_superfamily

13

true

false

This superfamily of proteins is involved in the inhibition of host uracil-DNA glycosylase (UDG), an essential enzyme in the base excision repair pathway that removes uracil from DNA. Members of this superfamily interact with UDG to prevent it from binding to DNA, thereby protecting viral genomes that contain uracil, wh...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.20.250.30" ]

[ "UDG_Inhib_phi29likevirus" ]

[ 13 ]

1

[]

0

[ "2le2", "3zoq", "4l5n" ]

3

[]

0

[]

0

null

[ "Salasmaviridae" ]

[ 13 ]

1

[]

0

true

Homologous_superfamily

UDG Inhibitor phi29likevirus

UDG_Inhib_phi29likevirus

8

IPR053745

53,745

Viral Tail Completion Superfamily

Viral_Tail_Comp_sf

Homologous_superfamily

4,104

true

false

This superfamily of proteins is involved in the assembly of viral structures, specifically by capping the tail of bacteriophages. Members of this superfamily function to ensure the proper attachment of the tail to the capsid, which is a critical step in the virus assembly process. They achieve this by interacting with ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.2000.30" ]

[ "Viral_Tail_Comp_sf" ]

[ 4104 ]

1

[]

0

[ "2lfp", "4acv", "5a20", "5a21", "6tba", "6te9", "6toa", "6tui", "9j1j" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinaceae", "Viruses", "metagenomes" ]

[ 3720, 2, 8, 273, 101 ]

5

[]

0

true

Homologous_superfamily

Viral Tail Completion Superfamily

Viral_Tail_Comp_sf

5

IPR053746

53,746

Viral Head-Tail Connector Assembly Factor

Viral_HT_Connector_Assembly

Homologous_superfamily

970

true

false

This superfamily of proteins is involved in the assembly of viral components, specifically participating in the formation of a structural interface between the viral head and tail. Members of this superfamily are characterized by their ability to form a central channel that is crucial for the DNA ejection process durin...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.246.150" ]

[ "Viral_HT_Connector_Assembly" ]

[ 970 ]

1

[]

0

[ "2kbz", "5a20", "5a21", "7z4w" ]

4

[]

0

[]

0

null

[ "Bacteria", "Methanococcus maripaludis", "Tritrichomonas musculus", "Viruses", "metagenomes" ]

[ 828, 1, 1, 127, 13 ]

5

[]

0

true

Homologous_superfamily

Viral Head-Tail Connector Assembly Factor

Viral_HT_Connector_Assembly

8

IPR053747

53,747

Fluorescence Recovery Regulator

Fluoresc_Recovery_Reg

Homologous_superfamily

410

true

false

This superfamily of proteins is involved in the photoprotection mechanism of photosynthetic organisms. Members of this superfamily interact with a specific form of the orange carotenoid protein, facilitating its conversion to a different state. This interaction is crucial for the regulation of a process known as non-ph...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.10.140.1840" ]

[ "Fluoresc_Recovery_Reg" ]

[ 410 ]

1

[]

0

[ "4jdq", "4jdx", "5tz0", "8ag8" ]

4

[]

0

[]

0

null

[ "Bacteria", "Methanocrinis", "ecological metagenomes" ]

[ 405, 2, 3 ]

3

[]

0

true

Homologous_superfamily

Fluorescence Recovery Regulator

Fluoresc_Recovery_Reg

5

IPR053748

53,748

Host DNA Degradation Endonuclease

Host_DNA_Degrad_Endo

Homologous_superfamily

469

true

false

This superfamily of proteins includes enzymes that are involved in the degradation of host DNA, which is a process that facilitates the recycling of nucleotides for the synthesis of viral DNA. Members of this superfamily exhibit sequence-specific endonuclease activity, cleaving the bottom strand of double-stranded DNA ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.40.1440.40" ]

[ "Host_DNA_Degrad_Endo" ]

[ 469 ]

1

[]

0

[ "2wsh" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Bilateria", "Viruses", "ecological metagenomes" ]

[ 10, 151, 14, 290, 4 ]

5

[]

0

true

Homologous_superfamily

Host DNA Degradation Endonuclease

Host_DNA_Degrad_Endo

3

IPR053749

53,749

Bacterial toxin-antitoxin system-associated superfamily

TA_system-associated_sf

Homologous_superfamily

554

true

false

This superfamily of proteins includes members that are typically involved in bacterial toxin-antitoxin systems. These proteins are often encoded by operons and function as toxins that can inhibit various cellular processes, such as DNA replication, transcription, and translation, leading to cell growth arrest or death....

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.10.450.420" ]

[ "TA_system-associated_sf" ]

[ 554 ]

1

[]

0

[ "2rsx", "8i2e", "8i2f", "8wt4" ]

4

[]

0

[]

0

null

[ "Bacillota", "Rhizophagus irregularis", "human gut metagenome" ]

[ 552, 1, 1 ]

3

[]

0

true

Homologous_superfamily

Bacterial toxin-antitoxin system-associated superfamily

TA_system-associated_sf

6

IPR053750

53,750

Programmed Cell Death 10 Homolog

PDCD10_Homolog

Homologous_superfamily

727

true

false

This superfamily of proteins is involved in various cellular processes including the maintenance of cellular structures and the regulation of vesicle transport. Members of this superfamily are implicated in the elongation of excretory canals during developmental stages, suggesting a role in morphogenesis. They are also...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.120.1950" ]

[ "PDCD10_Homolog" ]

[ 727 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Oceanotoga teriensis", "Opisthokonta" ]

[ 1, 726 ]

2

[ "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus" ]

[ 1, 1, 1, 1 ]

4

true

Homologous_superfamily

Programmed Cell Death 10 Homolog

PDCD10_Homolog

1

IPR053751

53,751

Viral Major Capsid Assembly

Viral_Major_Capsid_sf

Homologous_superfamily

328

true

false

This superfamily of proteins includes structural components of viral capsids. The major capsid protein is essential for the assembly and stability of the capsid, which is the protein shell of a virus that encloses its genetic material. These proteins are typically characterized by their ability to form the protective o...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.120.730" ]

[ "Viral_Major_Capsid_sf" ]

[ 328 ]

1

[]

0

[ "2vvf", "2w0c" ]

2

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "Vinavirales", "unclassified sequences" ]

[ 3, 288, 27, 10 ]

4

[]

0

true

Homologous_superfamily

Viral Major Capsid Assembly

Viral_Major_Capsid_sf

3

IPR053752

53,752

Small archaeal modifier domain-containing protein

SAM_domain_containing

Homologous_superfamily

294

true

false

This superfamily of proteins is involved in post-translational modification of substrate proteins through a process known as sampylation. Members of this superfamily function by covalently attaching to lysine residues on target proteins via an isopeptide bond formed with the C-terminal glycine carboxylate of the modifi...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:4.10.410.50" ]

[ "SAM_domain_containing" ]

[ 294 ]

1

[]

0

[ "2l32", "2lji", "4hrs" ]

3

[]

0

[]

0

null

[ "Stenosarchaea group" ]

[ 294 ]

1

[]

0

true

Homologous_superfamily

Small archaeal modifier domain-containing protein

SAM_domain_containing

5

IPR053754

53,754

Oligomannose-binding and Chitinase-activity Domain-containing Protein

OligoMan_bind_ChitinaseAct_sf

Homologous_superfamily

206

true

false

This superfamily of proteins encompasses carbohydrate-binding entities that recognize and interact with specific oligosaccharides, such as oligomannosides. Members of this superfamily are characterized by their ability to bind to a specific tetrasaccharide core found in N-linked oligomannosides with high affinity. They...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1490.230" ]

[ "OligoMan_bind_ChitinaseAct_sf" ]

[ 206 ]

1

[]

0

[ "1zhq", "1zhs" ]

2

[]

0

[]

0

null

[ "Bacteria", "Caudovirales sp. ctcT39", "Elysia marginata", "metagenomes" ]

[ 201, 1, 1, 3 ]

4

[]

0

true

Homologous_superfamily

Oligomannose-binding and Chitinase-activity Domain-containing Protein

OligoMan_bind_ChitinaseAct_sf

9

IPR053755

53,755

Contact-dependent growth inhibition immunity

CDI_immunity_sf

Homologous_superfamily

191

true

false

This superfamily of proteins encompasses immunity components within toxin-immunity modules, specifically functioning in contact-dependent growth inhibition (CDI) systems. These systems are utilized by bacteria to interact with and suppress the proliferation of closely related bacteria through direct contact. Members of...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.2450.20" ]

[ "CDI_immunity_sf" ]

[ 191 ]

1

[]

0

[ "4ntq" ]

1

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 190, 1 ]

2

[]

0

true

Homologous_superfamily

Contact-dependent growth inhibition immunity

CDI_immunity_sf

2

IPR053756

53,756

Toxin-specific immunity effector

Toxin_immunity_effector

Homologous_superfamily

129

true

false

This superfamily of proteins includes immune effectors involved in bacterial competition. Members function by binding to and inhibiting the activity of cognate toxins, thereby providing a defense mechanism against toxin-mediated cell damage. The interaction between these immune proteins and their target toxins is highl...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.287.2500" ]

[ "Toxin_immunity_effector" ]

[ 129 ]

1

[]

0

[ "3rq9", "3stq", "3vpv", "4c18", "5ako" ]

5

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Ochrophyta", "hydrothermal vent metagenome" ]

[ 125, 1, 2, 1 ]

4

[]

0

true

Homologous_superfamily

Toxin-specific immunity effector

Toxin_immunity_effector

7

IPR053757

53,757

Anti-restriction Endonuclease Superfamily

Anti-Restrict_Endo_sf

Homologous_superfamily

116

true

false

This superfamily of proteins includes enzymes that interact with host cell DNA to counteract restriction-modification systems. Members of this superfamily function by inhibiting host endonucleases that are specific for modified cytosine residues within DNA. These proteins are involved in protecting invading genetic ele...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.70.2770" ]

[ "Anti-Restrict_Endo_sf" ]

[ 116 ]

1

[]

0

[ "3wx4" ]

1

[]

0

[]

0

null

[ "Viruses" ]

[ 116 ]

1

[]

0

true

Homologous_superfamily

Anti-restriction Endonuclease Superfamily

Anti-Restrict_Endo_sf

3

IPR053758

53,758

Carboxypeptidase A Inhibitor I44

CPA_Inhibitor_I44

Homologous_superfamily

133

true

false

This superfamily of proteins includes members that function as inhibitors of carboxypeptidase A, an enzyme involved in the processing and maturation of proteins by removing amino acids from the carboxy terminus of peptides. Members of this superfamily are characterized by their ability to regulate the activity of carbo...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.40.170" ]

[ "CPA_Inhibitor_I44" ]

[ 133 ]

1

[]

0

[ "3fju" ]

1

[]

0

[]

0

null

[ "Bilateria" ]

[ 133 ]

1

[]

0

true

Homologous_superfamily

Carboxypeptidase A Inhibitor I44

CPA_Inhibitor_I44

3

IPR053759

53,759

CDI System Immunity Component

CDI_Immunity_Comp

Homologous_superfamily

82

true

false

This superfamily of proteins encompasses immunity components within toxin-immunity modules, which are implicated in contact-dependent growth inhibition (CDI) systems. These systems enable bacteria to interact with and suppress the proliferation of closely related bacteria upon direct contact. Members of this superfamil...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.70.2920" ]

[ "CDI_Immunity_Comp" ]

[ 82 ]

1

[]

0

[ "4g6v" ]

1

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 82 ]

1

[]

0

true

Homologous_superfamily

CDI System Immunity Component

CDI_Immunity_Comp

9

IPR053760

53,760

Benzylsuccinate Synthase-like

BSS-like_sf

Homologous_superfamily

43

true

false

This superfamily of proteins is involved in the enzymatic addition of fumarate to aromatic hydrocarbons, a key step in anaerobic toluene degradation. Members of this superfamily function as part of a multi-subunit enzyme complex, catalyzing the initial reaction in the anaerobic breakdown of toluene to benzylsuccinate. ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:4.10.490.20" ]

[ "BSS-like_sf" ]

[ 43 ]

1

[]

0

[ "4pkf", "5bwe", "9pzj" ]

3

[]

0

[]

0

null

[ "Bacteria" ]

[ 43 ]

1

[]

0

true

Homologous_superfamily

Benzylsuccinate Synthase-like

BSS-like_sf

2

IPR053761

53,761

Leguminous Lectin Domain-containing Protein

Leguminous_Lectin_Domain_sf

Homologous_superfamily

86

true

false

This superfamily of proteins is characterized by its ability to bind specific carbohydrate molecules. Members of this superfamily are involved in various biological processes, including cell-cell recognition, signaling, and host-pathogen interactions. They typically recognize and bind to mannose or glucose moieties, wh...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.4220" ]

[ "Leguminous_Lectin_Domain_sf" ]

[ 86 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Magnoliopsida" ]

[ 86 ]

1

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1 ]

2

true

Homologous_superfamily

Leguminous Lectin Domain-containing Protein

Leguminous_Lectin_Domain_sf

5

IPR053762

53,762

Toxin-Substrate Binding Inhibitor

Toxin-Sub_Inhibitor_sf

Homologous_superfamily

34

true

false

This superfamily of proteins includes immunity components that are involved in the inhibition of early activation of associated toxins. Members of this superfamily function by binding to the toxin's substrate binding site, thereby blocking the entry of the substrate and preventing the toxin's deleterious activity. This...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.120.1690" ]

[ "Toxin-Sub_Inhibitor_sf" ]

[ 34 ]

1

[]

0

[ "3wa5", "4luq", "4m5f", "4n7s", "4n80", "4n88", "8ik0", "8ik3" ]

8

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 34 ]

1

[]

0

true

Homologous_superfamily

Toxin-Substrate Binding Inhibitor

Toxin-Sub_Inhibitor_sf

9

IPR053763

53,763

Type III Secretion System Regulatory Protein

T3SS_Regulatory_Protein

Homologous_superfamily

39

true

false

This superfamily of proteins includes regulatory components that modulate the expression of type III secretion systems (T3SS) in bacteria. Members of this superfamily function as key regulators by interacting with other proteins to control the secretion machinery's activity. In non-inducing conditions, they maintain th...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.20.290.10" ]

[ "T3SS_Regulatory_Protein" ]

[ 39 ]

1

[]

0

[ "3kxy" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 39 ]

1

[]

0

true

Homologous_superfamily

Type III Secretion System Regulatory Protein

T3SS_Regulatory_Protein

2

IPR053764

53,764

Cell Envelope Biogenesis-Associated Superfamily

CellEnv_BiogenAssoc_sf

Homologous_superfamily

34

true

false

This superfamily of proteins is involved in the bacterial cell envelope biogenesis. Members of this superfamily are typically associated with the assembly and maintenance of the outer membrane, playing a role in the transport and incorporation of cell wall components. They may interact with other proteins or complexes ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.2290" ]

[ "CellEnv_BiogenAssoc_sf" ]

[ 34 ]

1

[]

0

[ "2jvu" ]

1

[]

0

[]

0

null

[ "Enterobacterales" ]

[ 34 ]

1

[]

0

true

Homologous_superfamily

Cell Envelope Biogenesis-Associated Superfamily

CellEnv_BiogenAssoc_sf

9

IPR053765

53,765

Antimicrobial Activity and Nucleic Acid-Binding Superfamily

Antimicro_NucAcidBind_sf

Homologous_superfamily

12

true

false

This superfamily of proteins includes members with antimicrobial activity, specifically targeting certain bacterial plant pathogens. They are capable of inhibiting the growth of bacteria such as Xanthomonas oryzae pv. oryzae and Ralstonia solanacearum. These proteins may also interact with nucleic acids, potentially bi...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.20.20.70" ]

[ "Antimicro_NucAcidBind_sf" ]

[ 12 ]

1

[]

0

[ "2b9k" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 12 ]

1

[]

0

true

Homologous_superfamily

Antimicrobial Activity and Nucleic Acid-Binding Superfamily

Antimicro_NucAcidBind_sf

4

IPR053766

53,766

Vaterite Nucleation and Antimicrobial Superfamily

Vaterite_Nuc_Antimicrob_sf

Homologous_superfamily

8

true

false

This superfamily of proteins is involved in the biomineralization process, specifically in the nucleation and stabilization of vaterite, a crystalline form of calcium carbonate. Members of this superfamily possess antimicrobial properties, effective against certain bacterial pathogens including Pseudomonas aeruginosa a...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.20.20.60" ]

[ "Vaterite_Nuc_Antimicrob_sf" ]

[ 8 ]

1

[]

0

[ "2jr3" ]

1

[]

0

[]

0

null

[ "Brevibacillus", "Pelodiscus sinensis" ]

[ 7, 1 ]

2

[]

0

true

Homologous_superfamily

Vaterite Nucleation and Antimicrobial Superfamily

Vaterite_Nuc_Antimicrob_sf

8

IPR053768

53,768

Intense Sweet-Taste Modifier

Sweet-Taste_Mod_sf

Homologous_superfamily

2

true

false

This superfamily of proteins includes members that are known for their role in modifying taste perception. They are characterized by their ability to elicit a sweet taste sensation, which is significantly more intense than that of common sugars. These proteins interact with taste receptors on the tongue to induce sweet...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:6.10.140.2000" ]

[ "Sweet-Taste_Mod_sf" ]

[ 2 ]

1

[]

0

[ "1fa3", "1fuw", "1iv7", "1iv9", "1krl", "1m9g", "1mnl", "1mol", "2o9u", "2q33", "3mon", "3pxm", "3pyj", "3q2p", "4mon", "5lc6", "5lc7", "5o7k", "5o7l", "5o7q", "5o7r", "5o7s", "5xfu", "5yct", "5ycu", "5ycw", "5z1p", "6l44", "6l4i", "6l4j", "6l4n", "6lay"...

49

[]

0

[]

0

null

[ "Mesangiospermae" ]

[ 2 ]

1

[]

0

true

Homologous_superfamily

Intense Sweet-Taste Modifier

Sweet-Taste_Mod_sf

4

IPR053772

53,772

FBD-associated F-box protein At1g61320/At1g61330-like

At1g61320/At1g61330-like

Family

13,724

true

This entry includes a group of plant proteins such as FBD-associated F-box protein At1g61320 and At1g61330 from Arabidopsis thaliana. These proteins contain a F-box motif, which is typically involved in protein-protein interactions. The F-box motif is a key component of the SCF (SKP1-cullin-F-box) complex, which functi...

[]

0

[ "PANTHER" ]

[ "PTHR34145" ]

[ "F-box_domain" ]

[ 13724 ]

1

[]

0

[]

0

[ "PUB00096545" ]

[ "23166809" ]

[ "A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota", "Legionella" ]

[ 13713, 11 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 244, 83 ]

3

true

Family

FBD-associated F-box protein At1g61320/At1g61330-like

At1g61320/At1g61330-like

9

IPR053773

53,773

Vpar_1526-like

Family

344

false

This family represents the homologues of Vpar_1526 protein from Veillonella parvula, that was proposed to be an inner membrane protein [ ]. It is predicted to fold into a mainly α-helical structure.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045477", "PF28206" ]

[ "LPO_1073_dom", "Vpar_1526" ]

[ 334, 344 ]

2

[]

0

[]

0

[ "PUB00153461", "PUB00153462" ]

[ "28713344", "27915212" ]

[ "Outer Membrane Proteome of <i>Veillonella parvula:</i> A Diderm Firmicute of the Human Microbiome.", "Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47." ]

[ 2017, 2017 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 328, 5, 2, 9 ]

4

[]

0

true

Family

Vpar_1526-like

5

IPR053774

53,774

Phenol regulator MopR

MopR

Family

79

false

This entry represents a group of proteins from Acinetobacter, including MopR from Acinetobacter guillouiae, which is involved in the regulation of the phenol degradation pathway. This NtrC-related sigma-54-dependent transcriptional activator activates phenol hydroxylase expression in the presence of phenol [ , ]. The s...

[ "GO:2001141" ]

[ "regulation of RNA biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "NF041906" ]

[ "V4R_TF_MobR" ]

[ 79 ]

1

[]

0

[]

0

[ "PUB00083146", "PUB00152967" ]

[ "9023219", "27362503" ]

[ "Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.", "Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator." ]

[ 1997, 2016 ]

2

[]

0

null

[ "Acinetobacter" ]

[ 79 ]

1

[]

0

true

Family

Phenol regulator MopR

MopR

9

IPR053775

53,775

Tungstate-binding protein TupA

TupA

Family

121

false

This entry represents a group of proteins from Campylobacterales, including Tungstate-binding protein TupA from Campylobacter jejuni, part of an ABC transporter complex involved in ultra-high affinity tungstate uptake. It specifically binds tungstate [ ].

[ "GO:1901238" ]

[ "ABC-type tungstate transporter activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF041772" ]

[ "tung_bind_TupA" ]

[ 121 ]

1

[]

0

[ "3kn3" ]

1

[ "PUB00113573" ]

[ "19818021" ]

[ "A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter." ]

[ 2009 ]

1

[ "IPR052738" ]

[]

1

0

1

[ "Campylobacterales" ]

[ 121 ]

1

[]

0

true

Family

Tungstate-binding protein TupA

TupA

2

IPR053776

53,776

Tungstate uptake system permease protein TupB

TupB

Family

109

false

This entry represents a group of proteins from Campylobacter, including Tungstate uptake system permease protein TupB from Campylobacter jejuni, part of an ABC transporter complex involved in ultra-high affinity tungstate uptake. It is probably responsible for the translocation of the substrate across the membrane [ ].

[ "GO:1901238" ]

[ "ABC-type tungstate transporter activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF041773" ]

[ "tung_perm_TupB" ]

[ 109 ]

1

[]

0

[]

0

[ "PUB00113573" ]

[ "19818021" ]

[ "A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter." ]

[ 2009 ]

1

[ "IPR049783" ]

[]

1

0

1

[ "Campylobacterales" ]

[ 109 ]

1

[]

0

true

Family

Tungstate uptake system permease protein TupB

TupB

5

IPR053777

53,777

Galactofuranose transporter permease protein YtfT

YtfT

Family

793

false

This entry represents a group of proteins from Enterobacterales, including Galactofuranose transporter permease protein YtfT from Escherichia coli, which is thought to be part of the ABC transporter complex, YtfQRT-YjfF, involved in galactofuranose transport.

[]

0

[ "NCBIFAM" ]

[ "NF041862" ]

[ "YtfT_transport" ]

[ 793 ]

1

[]

0

[]

0

[ "PUB00152883" ]

[ "30698741" ]

[ "The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function." ]

[ 2019 ]

1

[ "IPR001851" ]

[]

1

0

1

[ "Bacteria", "Trichuris trichiura" ]

[ 792, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Galactofuranose transporter permease protein YtfT

YtfT

6

IPR053778

53,778

Polyketide synthase Pks13

Pks13

Family

796

false

This entry represents a group of proteins from Mycobacteriales, including Polyketide synthase Pks13 from Mycobacterium tuberculosis whicch is involved in the biosynthesis of mycolic acids [ , , , ].

[]

0

[ "NCBIFAM" ]

[ "NF040607" ]

[ "mycolic_Pks13" ]

[ 796 ]

1

[]

0

[ "7uk4", "8cuy", "8cuz", "8cv0", "8cv1", "9f48" ]

6

[ "PUB00065702", "PUB00105733", "PUB00105854", "PUB00105855", "PUB00153714", "PUB00153715" ]

[ "22825853", "19436070", "29072327", "29761048", "23770708", "25467124" ]

[ "Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.", "The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.", "Impact of mycolic acid deficiency on cells of Corynebacterium glutamicum ATCC13869.", ...

[ 2012, 2009, 2018, 2018, 2013, 2014 ]

6

[ "IPR050091" ]

[]

1

0

1

[ "Mycobacteriales" ]

[ 796 ]

1

[]

0

true

Family

Polyketide synthase Pks13

Pks13

7

IPR053779

53,779

Gephyrin-like molybdotransferase receptor GlpR

GlpR

Family

2,932

false

This entry represents a group of sequences from actinomycetes, including the cell division protein GlpR from Corynebacterium glutamicum ( ), also known as SepX (septal protein X). Eukaryotic gephyrin-like molybdotransferase Glp and its membrane receptor GlpR bind to FtsZ and Wag31 to form a tight protein complex, which...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045516", "PF28211" ]

[ "SepX_GlpR_1", "GlpR" ]

[ 1135, 2932 ]

2

[]

0

[]

0

[ "PUB00153464" ]

[ "37679597" ]

[ "Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2838, 20, 74 ]

3

[]

0

true

Family

Gephyrin-like molybdotransferase receptor GlpR

GlpR

4

IPR053780

53,780

Gp66-like

Family

639

false

This entry represents Gp66 from Stanholtvirus sv1026b ( ) and similar uncharacterised bacterial sequences.

[]

0

[ "NCBIFAM" ]

[ "NF045478" ]

[ "XF1762_fam" ]

[ 639 ]

1

[]

0

[]

0

[ "PUB00153463" ]

[ "28831124" ]

[ "A novel inducible prophage from the mycosphere inhabitant Paraburkholderia terrae BS437." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Halobacteriales", "Opisthokonta", "metagenomes" ]

[ 576, 17, 8, 4, 34 ]

5

[]

0

true

Family

Gp66-like

7

IPR053781

53,781

F-box/LRR-repeat protein 13-like, F-box domain

F-box_AtFBL13-like

Domain

27,278

false

This entry includes F-box/LRR-repeat protein 13 (AtARP13) form Arabidopsis thaliana, which belongs to the largest subfamily of plant F-box proteins, F-box/LRR-repeat proteins (FBLs). It contains tandem leucine-rich repeats (LRRs) following the F-box domain at the N-terminal. Like other F-box proteins, they may be compo...

[]

0

[ "CDD" ]

[ "cd22160" ]

[ "F-box_AtFBL13-like" ]

[ 27278 ]

1

[]

0

[]

0

[ "PUB00147147", "PUB00147154" ]

[ "11077244", "17147637" ]

[ "F-box proteins in Arabidopsis.", "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." ]

[ 2000, 2006 ]

2

[ "IPR001810" ]

[]

1

0

1

[ "Spermatophyta" ]

[ 27278 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 628, 376, 39 ]

3

true

Domain

F-box/LRR-repeat protein 13-like, F-box domain

F-box_AtFBL13-like

5

IPR053782

53,782

Conjugal transfer protein TraW-like

TraW-like

Family

843

false

Members of this family represent conjugal plasmid transfer proteins, including TraW, predominantly found in proteobacteria. The term conjugal plasmid transfer is used for certain transfer systems, including that of IncI1 family plasmids. Note that an unrelated protein, also designated TraW, participates in the assembly...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF033888", "PF28212" ]

[ "conj_TraW", "TraW-like" ]

[ 673, 843 ]

2

[]

0

[]

0

[ "PUB00105401" ]

[ "25477379" ]

[ "High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4." ]

[ 2015 ]

1

[]

0

null

[ "Plasmid R64", "Pseudomonadati", "metagenomes" ]

[ 1, 839, 3 ]

3

[]

0

true

Family

Conjugal transfer protein TraW-like

TraW-like

7

IPR053783

53,783

Dockerin-like domain

Dockerin_dom_GC-type

Domain

76

false

This entry represents a domain often found at the C-terminal end of a group of bacterial proteins that begins and ends with a near invariant C, and GC, respectively. It shows sequence homology to the type I dockerin domain (see ), which likewise contains an internal repeat and which appears in strictly C-terminal posit...

[]

0

[ "NCBIFAM" ]

[ "NF041540" ]

[ "dockerin_GC" ]

[ 76 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "ecological metagenomes" ]

[ 13, 10, 53 ]

3

[]

0

true

Domain

Dockerin-like domain

Dockerin_dom_GC-type

7

IPR053784

53,784

Choice-of-anchor U domain

Choice_anch_U_dom

Domain

1,029

false

The uncharacterised choice-of-anchor U domain is found in a group of prokaryotic proteins.

[]

0

[ "NCBIFAM" ]

[ "NF041766" ]

[ "choice_anch_U" ]

[ 1029 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 19, 993, 17 ]

3

[]

0

true

Domain

Choice-of-anchor U domain

Choice_anch_U_dom

6

IPR053785

53,785

PhaP6-like

Family

193

false

This entry represents a group of proteins from proteobacteria, including PhaP6 from Cupriavidus necator (H16_B1988, ), a phasin with no visible effect on formation of PHB granules [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045536" ]

[ "phasin_PhaP6" ]

[ 193 ]

1

[]

0

[]

0

[ "PUB00153434", "PUB00153444" ]

[ "22923598", "28425176" ]

[ "Localization of poly(3-hydroxybutyrate) (PHB) granule-associated proteins during PHB granule formation and identification of two new phasins, PhaP6 and PhaP7, in Ralstonia eutropha H16.", "Polyhydroxyalkanoate-associated phasins as phylogenetically heterogeneous, multipurpose proteins." ]

[ 2012, 2017 ]

2

[]

0

null

[ "Pseudomonadati", "plant metagenome" ]

[ 187, 6 ]

2

[]

0

true

Family

PhaP6-like

7

IPR053786

53,786

LEPRxLL conserved site

LEPRxLL_CS

Conserved_site

609

false

This conserved site, which is about 24 amino acids long and contains the LEPRxLL motif, is found at the N-terminal of a group of bacterial repeat-filled giant proteins. Member proteins average over 8000 amino acids.

[]

0

[ "NCBIFAM" ]

[ "NF012209" ]

[ "LEPR-8K" ]

[ 609 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 575, 5, 29 ]

3

[]

0

true

Conserved_site

LEPRxLL conserved site

LEPRxLL_CS

4

IPR053788

53,788

CPC_1213-like

Family

172

false

This entry represents a family of small uncharacterised proteins found in Firmicutes. They are probably intrinsically disordered. Their function is unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF040908", "PF28213" ]

[ "CPC_1213_fam", "CPC_1213" ]

[ 172, 172 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "bioreactor metagenome" ]

[ 164, 8 ]

2

[]

0

true

Family

CPC_1213-like

7

IPR053789

53,789

Plasmid transfer protein TraA-like

TraA-like

Family

287

false

This entry represents uncharacterised proteins found mainly in Actinomycetes. These proteins are related to TraA plasmid transfer protein identified in Streptomyces plasmid pSN22, originating from Streptomyces nigrifaciens [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF041213", "PF28214" ]

[ "plasmid_TraA", "TraA-like" ]

[ 162, 287 ]

2

[]

0

[]

0

[ "PUB00106248" ]

[ "7991673" ]

[ "Complete nucleotide sequence of the Streptomyces nigrifaciens plasmid, pSN22: genetic organization and correlation with genetic properties." ]

[ 1994 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 287 ]

1

[]

0

true

Family

Plasmid transfer protein TraA-like

TraA-like

8

IPR053790

53,790

Pyrroline-5-carboxylate reductase-like conserved site

P5CR-like_CS

Conserved_site

23,383

false

Pyrroline-5-carboxylate reductase (P5CR) ( ) [ , ] is the enzyme that catalyses the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate intoproline. This enzyme is also able to convert delta-1-piperideine-6-carboxylate (P6C) into pipecolic acid [ ]; t...

[]

0

[ "PROSITE" ]

[ "PS00521" ]

[ "P5CR" ]

[ 23383 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.5.1.2", "PWY-3341", "PWY-8187", "R-BTA-8964539", "R-CEL-8964539", "R-DRE-8964539", "R-HSA-8964539", "R-MMU-8964539", "R-RNO-8964539", "R-SCE-8964539", "R-SPO-8964539" ]

[ "EC:1.5.1.2", "METACYC:PWY-3341", "METACYC:PWY-8187", "REACTOME:R-BTA-8964539", "REACTOME:R-CEL-8964539", "REACTOME:R-DRE-8964539", "REACTOME:R-HSA-8964539", "REACTOME:R-MMU-8964539", "REACTOME:R-RNO-8964539", "REACTOME:R-SCE-8964539", "REACTOME:R-SPO-8964539" ]

11

[ "2ger", "2gr9", "2gra", "2izz", "3gt0", "5bse", "5bsf", "5bsg", "5bsh", "5uat", "5uau", "5uav", "5uaw", "5uax", "6lhm", "6xoz", "6xp0", "6xp1", "6xp2", "6xp3", "8dkg", "8tcu", "8tcv", "8tcw", "8tcx", "8tcy", "8tcz", "8td0", "8td1", "8td2", "8td3", "8td4"...

45

[ "PUB00001785", "PUB00003735", "PUB00081473", "PUB00081474", "PUB00094509", "PUB00153734", "PUB00153735" ]

[ "2107123", "2199815", "24431009", "25058475", "29373009", "29686660", "37746209" ]

[ "Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.", "A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated.", "Human pyrroline-5-carbo...

[ 1990, 1990, 2014, 2014, 2018, 2018, 2022 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 149, 16573, 6354, 307 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 1, 9, 6, 1, 22, 5, 1, 5, 8, 1, 1, 7 ]

13

true

Conserved_site

Pyrroline-5-carboxylate reductase-like conserved site

P5CR-like_CS

5

IPR053791

53,791

Trichothecene efflux pump Tri12

MFS_Tri12-like

Family

1,914

false

This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in the species self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, a...

[]

0

[ "CDD" ]

[ "cd06179" ]

[ "MFS_TRI12_like" ]

[ 1914 ]

1

[]

0

[]

0

[ "PUB00012757", "PUB00143461" ]

[ "10485289", "26227913" ]

[ "TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast.", "Effect of disrupting the trichothecene efflux pump encoded by FgTri12 in the nivalenol chemotype of Fusarium graminearum." ]

[ 1999, 2015 ]

2

[ "IPR010573" ]

[]

1

0

1

[ "Dikarya" ]

[ 1914 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Trichothecene efflux pump Tri12

MFS_Tri12-like

9

IPR053792

53,792

ATP P2X receptor, conserved site

P2X_RECEPTOR_CS

Conserved_site

5,838

false

This entry represents a conserved region in P2X purinoceptors, located in the central part of the extracellular domain, which contains two of the conserved cysteines. P2X purinoceptors are cation-selective ion channels that open on binding to extracellular ATP; they play a role in fast synaptic transmission between neu...

[]

0

[ "PROSITE" ]

[ "PS01212" ]

[ "P2X_RECEPTOR" ]

[ 5838 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-139853", "R-BTA-418346", "R-DRE-139853", "R-DRE-418346", "R-HSA-139853", "R-HSA-418346", "R-HSA-6798695", "R-HSA-844456", "R-HSA-9660826", "R-HSA-9856532", "R-MMU-139853", "R-MMU-418346", "R-MMU-6798695", "R-MMU-844456", "R-RNO-139853", "R-RNO-418346", "R-RNO-6798695", "R-RN...

[ "REACTOME:R-BTA-139853", "REACTOME:R-BTA-418346", "REACTOME:R-DRE-139853", "REACTOME:R-DRE-418346", "REACTOME:R-HSA-139853", "REACTOME:R-HSA-418346", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-844456", "REACTOME:R-HSA-9660826", "REACTOME:R-HSA-9856532", "REACTOME:R-MMU-139853", "REACTOME:R-MMU-...

18

[ "3h9v", "3i5d", "4dw0", "4dw1", "5svj", "5svk", "5svl", "5svm", "5svp", "5svq", "5svr", "5svs", "5svt", "5u1l", "5u1u", "5u1v", "5u1w", "5u1x", "5u1y", "5u2h", "5wzy", "5yve", "6ah4", "6ah5", "6u9v", "6u9w", "8jv5", "8jv6", "8jv7", "8jv8", "8tr5", "8tr6"...

69

[ "PUB00005548", "PUB00005558", "PUB00006451", "PUB00007054", "PUB00100494" ]

[ "7541920", "7624972", "10414359", "12270951", "29631184" ]

[ "P2X receptors bring new structure to ligand-gated ion channels.", "How should P2X purinoceptors be classified pharmacologically?", "Functional and molecular diversity of purinergic ion channel receptors.", "Molecular physiology of P2X receptors.", "Modulation of innate and adaptive immunity by P2X ion chan...

[ 1995, 1995, 1999, 2002, 2018 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 5838 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 21, 30, 54 ]

4

true

Conserved_site

ATP P2X receptor, conserved site

P2X_RECEPTOR_CS

7

IPR053793

53,793

PB1-like domain

PB1-like

Domain

62,135

false

The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [ , , , ]. The PB1 domain is found in several signaling proteins including: - Mammalia...

[]

0

[ "PROFILE" ]

[ "PS51745" ]

[ "PB1" ]

[ 62135 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1912408", "R-CEL-204005", "R-CEL-2173791", "R-CEL-5218921", "R-CEL-9013149", "R-CEL-9013420", "R-CEL-9013424", "R-CEL-9634635", "R-CEL-9755511", "R-DME-2173791", "R-DME-5205685", "R-DME-5218921", "R-DME-9634635", "R-DME-9664873", "R-DME-9755511", "R-DRE-209543", "R-DRE-420029"...

[ "REACTOME:R-CEL-1912408", "REACTOME:R-CEL-204005", "REACTOME:R-CEL-2173791", "REACTOME:R-CEL-5218921", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013420", "REACTOME:R-CEL-9013424", "REACTOME:R-CEL-9634635", "REACTOME:R-CEL-9755511", "REACTOME:R-DME-2173791", "REACTOME:R-DME-5205685", "REACTOME...

97

[ "1ip9", "1ipg", "1oey", "1pqs", "1q1o", "1tz1", "1vd2", "1wi0", "1wj6", "1wmh", "2bkf", "2c60", "2cu1", "2dyb", "2g4s", "2jrh", "2kfj", "2kfk", "2kkc", "2ktr", "2m1m", "2muk", "2npt", "2o2v", "2pph", "4chk", "4ic7", "4mjs", "4nj6", "4nj7", "4uf8", "4uf9"...

41

[ "PUB00026089", "PUB00032270", "PUB00074810", "PUB00074811" ]

[ "11483498", "15590654", "17726178", "24706860" ]

[ "Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif.", "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.", "Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and...

[ 2001, 2005, 2007, 2014 ]

4

[]

[ "IPR000270" ]

0

1

0

[ "Bacteria", "Eukaryota", "invertebrate metagenome" ]

[ 13, 62121, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 627, 3, 30, 3, 61, 45, 4, 139, 62, 2, 3, 545 ]

12

true

Domain

PB1-like domain

PB1-like

5

IPR053794

53,794

A-adding tRNA nucleotidyltransferase

A-adding_TNT

Family

21

false

This entry represents a family of proteins from Geobacteraceae, including A-adding tRNA nucleotidyltransferase from Geobacter sulfurreducens, which is involved in the synthesis of the tRNA CCA terminus. It adds the terminal adenosine residue to tRNA [ ].

[ "GO:0000049", "GO:0008033" ]

[ "tRNA binding", "tRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF041569" ]

[ "A-tRNAntase" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00151383" ]

[ "18952795" ]

[ "Geobacter sulfurreducens contains separate C- and A-adding tRNA nucleotidyltransferases and a poly(A) polymerase." ]

[ 2009 ]

1

[]

0

null

[ "Geobacteraceae" ]

[ 21 ]

1

[]

0

true

Family

A-adding tRNA nucleotidyltransferase

A-adding_TNT

3

IPR053795

53,795

HTH-type transcriptional regulator lrs14

Lrs14

Family

109

false

This entry represents a group of archaeal proteins, including HTH-type transcriptional regulator lrs14 from Saccharolobus solfataricus, which acts in transcription regulation. It binds to multiple sequences in its own promoter [ ].

[ "GO:0003700" ]

[ "DNA-binding transcription factor activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF040939" ]

[ "trans_reg_lrs14" ]

[ 109 ]

1

[]

0

[]

0

[ "PUB00106079" ]

[ "10049378" ]

[ "An Lrp-like protein of the hyperthermophilic archaeon Sulfolobus solfataricus which binds to its own promoter." ]

[ 1999 ]

1

[]

0

null

[ "Thermoprotei" ]

[ 109 ]

1

[]

0

true

Family

HTH-type transcriptional regulator lrs14

Lrs14

9

IPR053796

53,796

tRNA (guanine(6)-N2)-methyltransferase-like

Trm14-like

Family

44

false

This entry represents tRNA (guanine(6)-N2)-methyltransferase from Pyrococcus furiosus (Trm14) and similar proteins from Thermococcales. Trm14 is a S-adenosyl-L-methionine-dependent methyltransferase responsible for the methylation of guanosine nucleotides at position 6 in tRNA, specifically modifying tRNA(Phe) [ , ]. M...

[ "GO:0003723", "GO:0008168", "GO:0008033" ]

[ "RNA binding", "methyltransferase activity", "tRNA processing" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "NF040850" ]

[ "Trm14_Thcoccales" ]

[ 44 ]

1

[]

0

[ "3tlj", "3tm4", "3tm5" ]

3

[ "PUB00058415", "PUB00106020", "PUB00106021" ]

[ "22362751", "22102250", "22337946" ]

[ "Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life.", "Crystallization and preliminary X-ray crystallographic analysis of putative tRNA-modification enzymes from Pyrococcus furiosus and Thermus thermophilus.", "The open reading frame TTC1157 of Thermus thermophilus HB27 e...

[ 2012, 2011, 2012 ]

3

[]

0

null

[ "Thermococcaceae" ]

[ 44 ]

1

[]

0

true

Family

tRNA (guanine(6)-N2)-methyltransferase-like

Trm14-like

5

IPR053797

53,797

Cypemycin cysteine dehydrogenase (decarboxylating)-like

CypD-like

Family

17

false

This entry represents Cypemycin cysteine dehydrogenase (decarboxylating) from Streptomyces sp. (CypD) and similar sequences from actinobacteria. CypD, a Cys decarboxylase flavoprotein, oxidatively removes the carboxyl moiety from the C-terminal Cys residue of CypA, the precursor of the RiPP natural product cypemycin [ ...

[]

0

[ "NCBIFAM" ]

[ "NF033753" ]

[ "RiPP_decarbCypD" ]

[ 17 ]

1

[]

0

[ "6jdd" ]

1

[ "PUB00105300" ]

[ "20805503" ]

[ "Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides." ]

[ 2010 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 17 ]

1

[]

0

true

Family

Cypemycin cysteine dehydrogenase (decarboxylating)-like

CypD-like

4