interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR053798 | 53,798 | Indoleacetate decarboxylase-like | IAD-like | Family | 16 | false | false | This entry includes Indoleacetate decarboxylase (IAD) from Tractidigestivibacter scatoligenes and similar bacterial sequences. IAD is a single subunit glycyl radical enzyme that depends on a cognate radical SAM enzyme for its activation. It performs the final step in the anaerobic fermentation of tryptophan to skatole,... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033718"
] | [
"indole_decarb"
] | [
16
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105269"
] | [
"30310076"
] | [
"Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole."
] | [
2018
] | 1 | [
"IPR051215"
] | [] | 1 | 0 | 1 | [
"Bacillati"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Indoleacetate decarboxylase-like | Indoleacetate decarboxylase-like | IAD-like | 9 |
IPR053799 | 53,799 | UTP--glucose-1-phosphate uridylyltransferase AglF-like | AglF-like | Family | 418 | false | false | This entry represents a family of proteins from halobacteria, including UTP--glucose-1-phosphate uridylyltransferase AglF from Haloferax volcanii. AglF is involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. It is also involved in the biosynthesis of the hexuron... | [
"GO:0016779"
] | [
"nucleotidyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"NF041313"
] | [
"UDPGP_AglF_Halo"
] | [
418
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106302",
"PUB00106303",
"PUB00106322"
] | [
"20487296",
"22730124",
"18631242"
] | [
"N-glycosylation in Archaea: on the coordinated actions of Haloferax volcanii AglF and AglM.",
"N-glycosylation of Haloferax volcanii flagellins requires known Agl proteins and is essential for biosynthesis of stable flagella.",
"AglF, aglG and aglI, novel members of a gene island involved in the N-glycosylatio... | [
2010,
2012,
2008
] | 3 | [
"IPR050065"
] | [] | 1 | 0 | 1 | [
"Halobacteria"
] | [
418
] | 1 | [] | [] | 0 | true | Family | UTP--glucose-1-phosphate uridylyltransferase AglF-like | UTP--glucose-1-phosphate uridylyltransferase AglF-like | AglF-like | 4 |
IPR053800 | 53,800 | Thc1, RRM domain | Thc1_RRM | Domain | 320 | false | false | The founder of this entry is a domain found in Thc1 protein from Schizosaccharomyces pombe. This protein is a subunit of sno(s)RNA-containing ribonucleoprotein complex and is involved in snRNA processing [ ]. This domain is predicted to adopt a typical RRM fold with a significant similarity to Poly (A)-specific ribonuc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22877"
] | [
"RRM_Thc1"
] | [
320
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154278"
] | [
"37403782"
] | [
"The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
320
] | 1 | [
"Danio rerio",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Thc1, RRM domain | Thc1, RRM domain | Thc1_RRM | 6 |
IPR053801 | 53,801 | Protein of unknown function DUF6959 | DUF6959 | Family | 233 | false | false | This is a family of uncharacterised bacterial proteins. They contain conserved Pro-Gly-rich motif with a semi- conserved pattern PGRxFPGx3QGD. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22281"
] | [
"DUF6959"
] | [
233
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
231,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF6959 | Protein of unknown function DUF6959 | DUF6959 | 7 |
IPR053802 | 53,802 | Domain of unknown function DUF6950 | DUF6950 | Domain | 1,415 | false | false | This domain is found in a group of uncharacterised proteins, mainly from proteobacteria. It is related to NlpC/P60 domains and it is likely to adopt similar structure as well as to possess an endopeptidase activity. All members of this family contain a conserved cysteine residue that is predicted to occupy equivalent s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22262"
] | [
"DUF6950"
] | [
1415
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"asterids",
"metagenomes"
] | [
1289,
93,
2,
31
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6950 | Domain of unknown function DUF6950 | DUF6950 | 4 |
IPR053803 | 53,803 | Protein of unknown function DUF6949 | DUF6949 | Family | 469 | false | false | This is a family of uncharacterised proteins mainly found in proteobacteria. These proteins are enriched with hydrophobic residues and it is quite likely to be associated with the membrane. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22258"
] | [
"DUF6949"
] | [
469
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"Effrenium voratum",
"hydrothermal vent metagenome"
] | [
465,
1,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF6949 | Protein of unknown function DUF6949 | DUF6949 | 2 |
IPR053804 | 53,804 | Protein of unknown function DUF6960 | DUF6960 | Family | 165 | false | false | This is a family of uncharacterised bacterial proteins. They are composed of two tandem domains with similarity to SH3 domains, in particular to YorP. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22283"
] | [
"DUF6960"
] | [
165
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
165
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF6960 | Protein of unknown function DUF6960 | DUF6960 | 5 |
IPR053805 | 53,805 | Bacteriophage N4 RNA polymerase, helical domain | N4_RNAP_helical | Domain | 118 | false | false | This is a helical domain, also known as 'Fingers subdomain', found in the bacteriophage N4 virion RNA polymerase [ ]. This domain possesses two essential functions of the RNAP: the N-terminal part plays a role in the nucleotide addition cycle, whereas the C-terminal part is involved in promoter recognition [ ]. A swing... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21894"
] | [
"N4_RNAP_helical"
] | [
118
] | 1 | [] | [] | [] | 0 | [
"2po4",
"3c2p",
"3c3l",
"3c46",
"3q0a",
"3q22",
"3q23",
"3q24",
"4ff1",
"4ff2",
"4ff3",
"4ff4"
] | 12 | [
"PUB00048738",
"PUB00050871",
"PUB00055751"
] | [
"18362338",
"19061645",
"21321236"
] | [
"X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase.",
"Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase.",
"X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucl... | [
2008,
2008,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Lucilia cuprina",
"Pseudomonadota",
"Viruses",
"marine metagenome"
] | [
1,
6,
110,
1
] | 4 | [] | [] | 0 | true | Domain | Bacteriophage N4 RNA polymerase, helical domain | Bacteriophage N4 RNA polymerase, helical domain | N4_RNAP_helical | 1 |
IPR053806 | 53,806 | MTHFR, SAM-binding regulatory domain | MTHFR_C | Domain | 6,520 | false | false | This is the C-terminal SAM-binding regulatory domain of 5,10-methylenetetrahydrofolate reductase (MTHFR) that follows the catalytic domain and is unique to eukaryotes. This domain provides the required interface for MTHFR homo-dimerization, thus positioning the N-terminal serine-rich phosphorylation region near the SAM... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21895"
] | [
"MTHFR_C"
] | [
6520
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.5.1",
"R-CEL-196757",
"R-HSA-196757",
"R-MMU-196757",
"R-SCE-196757",
"R-SPO-196757"
] | [
"EC:1.5.1",
"REACTOME:R-CEL-196757",
"REACTOME:R-HSA-196757",
"REACTOME:R-MMU-196757",
"REACTOME:R-SCE-196757",
"REACTOME:R-SPO-196757"
] | 6 | [
"6fcx",
"8qa4",
"8qa5",
"8qa6",
"8uy1",
"8uy2"
] | 6 | [
"PUB00101947"
] | [
"29891918"
] | [
"Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
3,
6509,
8
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
8,
1,
1,
9,
7,
2,
6,
8,
2,
2,
14
] | 11 | true | Domain | MTHFR, SAM-binding regulatory domain | MTHFR, SAM-binding regulatory domain | MTHFR_C | 7 |
IPR053808 | 53,808 | Cell wall binding protein Cwp8, domain 2 | Cwp8_D2 | Domain | 12 | false | false | Cwp8 is a member of the C. difficile cell wall protein (CWP) family. It consists of several domains. This entry represents domain 2 (D2) that is a part of the N-terminal elongated region of the molecule [ ]. This domain is composed of a three-stranded antiparallel β-sheet, an α-helix packed on it and a short β-hairpin ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22093"
] | [
"Cwp8_D2"
] | [
12
] | 1 | [] | [] | [] | 0 | [
"5j6q"
] | 1 | [
"PUB00106918"
] | [
"28132783"
] | [
"The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Peptostreptococcaceae"
] | [
12
] | 1 | [] | [] | 0 | true | Domain | Cell wall binding protein Cwp8, domain 2 | Cell wall binding protein Cwp8, domain 2 | Cwp8_D2 | 1 |
IPR053809 | 53,809 | Cell wall binding protein Cwp8, domain 3 | Cwp8_D3 | Domain | 11 | false | false | This entry represents the third domain (D3) of cell wall protein Cwp8, found in C. difficile. This domain folds into an α/β structure consisting of a four-stranded antiparallel β-sheet packed on one side with α-helices [ ]. This domain is related to domain 1 (D1) of the cell wall protein Cwp2 from the same organism. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22135"
] | [
"Cwp8_D3"
] | [
11
] | 1 | [] | [] | [] | 0 | [
"5j6q"
] | 1 | [
"PUB00106918"
] | [
"28132783"
] | [
"The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Clostridioides difficile"
] | [
11
] | 1 | [] | [] | 0 | true | Domain | Cell wall binding protein Cwp8, domain 3 | Cell wall binding protein Cwp8, domain 3 | Cwp8_D3 | 5 |
IPR053810 | 53,810 | Protein of unknown function DUF6952 | DUF6952 | Family | 1,301 | false | false | This is a family of uncharacterised bacterial proteins. They contain highly conserved acidic residues and G[S/A]ID motif at the C terminus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22264"
] | [
"DUF6952"
] | [
1301
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Siphoviridae sp. ctYaH2",
"ecological metagenomes"
] | [
1296,
1,
4
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF6952 | Protein of unknown function DUF6952 | DUF6952 | 3 |
IPR053811 | 53,811 | 2'-deoxycytidine 5'-triphosphate deaminase, C-terminal domain | DCD_C | Domain | 2,144 | false | false | This entry includes 2'-deoxycytidine 5'-triphosphate deaminase proteins ( ) (DCD) from a set of mainly alphaproteobacteria, which consist of two dUTPase-like domains ( ). This entry represents the C-terminal domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22569"
] | [
"DCD_C"
] | [
2144
] | 1 | [] | [] | [] | 0 | [
"2r9q"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2103,
8,
33
] | 3 | [] | [] | 0 | true | Domain | 2'-deoxycytidine 5'-triphosphate deaminase, C-terminal domain | 2'-deoxycytidine 5'-triphosphate deaminase, C-terminal domain | DCD_C | 1 |
IPR053812 | 53,812 | RNA polymerase sigma-70 ECF-like, HTH domain | HTH_Sigma70_ECF-like | Domain | 4,074 | false | false | This entry represents a HTH domain at the C-terminal found in uncharacterised YagL from Escherichia coli and probable RNA polymerase sigma-70 ECF-like proteins. Sigma factors are able to regulate ECF [ ]. Eubacteria display considerable genetic diversity between ECF-sigma factors, but all retain two features: the abili... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07638"
] | [
"Sigma70_ECF"
] | [
4074
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014743",
"PUB00016691"
] | [
"12073657",
"15374527"
] | [
"The extracytoplasmic function (ECF) sigma factors.",
"The extracytoplasmic function sigma factors: role in bacterial pathogenesis."
] | [
2002,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"Viruses",
"unclassified sequences"
] | [
4000,
20,
3,
5,
46
] | 5 | [
"Escherichia coli (strain K12)",
"Zea mays"
] | [
1,
1
] | 2 | true | Domain | RNA polymerase sigma-70 ECF-like, HTH domain | RNA polymerase sigma-70 ECF-like, HTH domain | HTH_Sigma70_ECF-like | 2 |
IPR053813 | 53,813 | CATSPERD, beta-propeller domain | CATSPERD_beta-prop | Domain | 363 | false | false | This entry represents the β-propeller domain of the delta subunit (CATSPERD) [ ]. The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactiva... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15020"
] | [
"Beta-prop_CATSPERD"
] | [
363
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642",
"R-RNO-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642",
"REACTOME:R-RNO-1300642"
] | 3 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00100197"
] | [
"21224844",
"34225353"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"Structure of a mammalian sperm cation channel complex."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
363
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
5
] | 3 | true | Domain | CATSPERD, beta-propeller domain | CATSPERD, beta-propeller domain | CATSPERD_beta-prop | 2 |
IPR053815 | 53,815 | CATSPERE, Ig-like domain | CATSPERE_Ig-like | Domain | 390 | false | false | The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation, a process needed for sperm motility, which is essential late in the preparat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22849"
] | [
"CATSPERE_Ig-like"
] | [
390
] | 1 | [] | [] | [] | 0 | [
"7eeb"
] | 1 | [
"PUB00100197"
] | [
"34225353"
] | [
"Structure of a mammalian sperm cation channel complex."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
390
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
5
] | 3 | true | Domain | CATSPERE, Ig-like domain | CATSPERE, Ig-like domain | CATSPERE_Ig-like | 1 |
IPR053816 | 53,816 | CATSPERE, beta-propeller domain | CATSPERE_beta-prop | Domain | 414 | false | false | The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation, a process needed for sperm motility, which is essential late in the preparat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22844"
] | [
"Beta-prop_CATSPERE"
] | [
414
] | 1 | [] | [] | [] | 0 | [
"7eeb"
] | 1 | [
"PUB00100197"
] | [
"34225353"
] | [
"Structure of a mammalian sperm cation channel complex."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
414
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
5
] | 3 | true | Domain | CATSPERE, beta-propeller domain | CATSPERE, beta-propeller domain | CATSPERE_beta-prop | 3 |
IPR053817 | 53,817 | CATSPERE, second N-terminal domain | CATSPERE_NTD2 | Domain | 312 | false | false | This entry includes CATSPERE, the auxiliary subunit epsilon of the CatSper complex, a complex involved in sperm cell hyperactivation. This process is needed for sperm motility, which is essential late in the preparation of sperm for fertilisation [ ]. This is a multi-domain protein which has a similar domain organisati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22843"
] | [
"CATSPERE_NTD2"
] | [
312
] | 1 | [] | [] | [] | 0 | [
"7eeb"
] | 1 | [
"PUB00100197"
] | [
"34225353"
] | [
"Structure of a mammalian sperm cation channel complex."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
312
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
5
] | 3 | true | Domain | CATSPERE, second N-terminal domain | CATSPERE, second N-terminal domain | CATSPERE_NTD2 | 7 |
IPR053819 | 53,819 | TEAD interacting region 3, omega loop | TEADIR3_omega_loop | Conserved_site | 3,125 | false | false | This entry represents the third TEAD interacting region (omega loop) present in YAP/TAZ, FAM181, and PERCC1 families [ , , , , ]. This conserved region is remotely related to the omega loop found in the Vestigial family (VGLL2 and VGLL3) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15238"
] | [
"TEADIR3"
] | [
3125
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-1251985",
"R-CFA-2028269",
"R-CFA-2032785",
"R-CFA-8939236",
"R-CFA-8951671",
"R-CFA-9860927",
"R-DME-390098",
"R-DME-390193",
"R-DME-451806",
"R-DRE-1251985",
"R-DRE-2028269",
"R-DRE-8939236",
"R-DRE-9860927",
"R-HSA-1251985",
"R-HSA-2028269",
"R-HSA-2032785",
"R-HSA-8939236"... | [
"REACTOME:R-CFA-1251985",
"REACTOME:R-CFA-2028269",
"REACTOME:R-CFA-2032785",
"REACTOME:R-CFA-8939236",
"REACTOME:R-CFA-8951671",
"REACTOME:R-CFA-9860927",
"REACTOME:R-DME-390098",
"REACTOME:R-DME-390193",
"REACTOME:R-DME-451806",
"REACTOME:R-DRE-1251985",
"REACTOME:R-DRE-2028269",
"REACTOME:R... | 37 | [
"3jua",
"3kys",
"5oaq",
"6ge3",
"6ge4",
"6ge5",
"6ge6",
"6gec",
"6gee",
"6geg",
"6gei",
"6gek",
"6hik",
"6hil",
"6l9f",
"6q2x",
"6sen",
"6seo",
"8a8q",
"8a8r",
"9fza"
] | 21 | [
"PUB00100082",
"PUB00154264",
"PUB00154265",
"PUB00154266",
"PUB00154267",
"PUB00154268"
] | [
"22632831",
"33060790",
"31697419",
"36699391",
"36076104",
"31217582"
] | [
"Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.",
"A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.",
"Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.",
"<i>PERCC1</i>... | [
2012,
2020,
2020,
2022,
2023,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3125
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
5,
10,
14
] | 5 | true | Conserved_site | TEAD interacting region 3, omega loop | TEAD interacting region 3, omega loop | TEADIR3_omega_loop | 8 |
IPR053820 | 53,820 | MSL3 chromodomain-like | MSL3_chromo-like | Domain | 5,457 | false | false | This domain is found in Male-specific lethal-3 (MSL3) and other related proteins such as MRG1/2 transcription factors. MSL3 resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 acetyl mark. The MSL3 chromo domain implicated in chromatin targeting and its d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22732"
] | [
"MSL3_chromo-like"
] | [
5457
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-3214847",
"R-HSA-3214847",
"R-MMU-3214847"
] | [
"REACTOME:R-DME-3214847",
"REACTOME:R-HSA-3214847",
"REACTOME:R-MMU-3214847"
] | 3 | [
"2efi",
"2f5k",
"2k3x",
"2k3y",
"3e9f",
"3e9g",
"3m9q",
"3oa6",
"3ob9",
"4pl6",
"4pli",
"4pll",
"5in1",
"6k5w",
"7yi0",
"7yi1",
"7yi2",
"7yi3",
"7yi4",
"7yi5",
"8hxx",
"8hxy",
"8hxz",
"8hy0",
"8i02",
"8ifg",
"8ihm",
"8ihn",
"8iht",
"8jho",
"8kc7",
"8kd2"... | 42 | [
"PUB00047430",
"PUB00048222",
"PUB00048760",
"PUB00074563",
"PUB00103208",
"PUB00154419",
"PUB00154420",
"PUB00154421"
] | [
"17135209",
"18818090",
"18026117",
"20657587",
"22247551",
"20943666",
"30224647",
"33837287"
] | [
"Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3.",
"Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S.",
"L3MBTL1 recognition of mono- and dimethylated histones.",
"Corecognition of DNA and a methyla... | [
2006,
2008,
2007,
2010,
2012,
2010,
2018,
2021
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Parvicella tangerina"
] | [
5456,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S... | [
5,
1,
3,
10,
5,
1,
2,
6,
1,
1,
7
] | 11 | true | Domain | MSL3 chromodomain-like | MSL3 chromodomain-like | MSL3_chromo-like | 7 |
IPR053821 | 53,821 | Splicing regulator SDE2, ubiquitin domain | Sde2_Ubi | Domain | 756 | false | false | This entry represents the ubiquitin-fold domain found at the N-terminal of human SDE2 (Splicing regulator SDE2, also known as silencing defective 2) and similar proteins from vertebrates. SDE2 in a splicing regulator that supports splicing of selected pre-mRNAs in an intron-specific manner [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22781"
] | [
"Sde2_N_Ubi_vert"
] | [
756
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 4 | [
"8c6j",
"8ro2",
"9fmd"
] | 3 | [
"PUB00101934"
] | [
"27906959"
] | [
"PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
756
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
3
] | 4 | true | Domain | Splicing regulator SDE2, ubiquitin domain | Splicing regulator SDE2, ubiquitin domain | Sde2_Ubi | 6 |
IPR053822 | 53,822 | SDE2-like domain | SDE2-like_dom | Domain | 4,186 | false | false | SDE2 (silencing defective 2) is a ubiquitin-fold-containing splicing regulator that supports splicing of selected pre-mRNAs in an intron-specific manner in Schizosaccharomyces pombe. This splicing regulator is conserved among intron-rich eukaryotes up to humans, but is absent in intron-poor organisms such as S. cerevis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22782"
] | [
"SDE2"
] | [
4186
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 4 | [
"6qdv",
"8c6j",
"8ro1",
"8ro2",
"9fmd",
"9l5r",
"9l5t"
] | 7 | [
"PUB00091018",
"PUB00101901",
"PUB00101933",
"PUB00101934",
"PUB00154351"
] | [
"28947618",
"36095128",
"34365507",
"27906959",
"35850305"
] | [
"Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.",
"Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.",
"SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.",
... | [
2018,
2022,
2021,
2016,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4186
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
6,
1,
2,
1,
1,
1,
1,
3,
3,
1,
7
] | 11 | true | Domain | SDE2-like domain | SDE2-like domain | SDE2-like_dom | 4 |
IPR053823 | 53,823 | CLIC, N-terminal domain | CLIC_N | Domain | 6,826 | false | false | This entry represents the N-terminal domain of chloride ion channels CLIC and related sequences. The chloride intracellular channel (CLICs) belong to the glutathione-S-transferase (GSTs) superfamily, highly conserved in vertebrates which usually possess six distinct paralogues (CLIC1-CLIC6) [ , , ]. They are auto-inser... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF22441",
"cd03061"
] | [
"CLIC-like_N",
"GST_N_CLIC"
] | [
6826,
5836
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2672351",
"R-HSA-5578775",
"R-HSA-9662360",
"R-HSA-9662361",
"R-RNO-2672351",
"R-RNO-5578775"
] | [
"REACTOME:R-HSA-2672351",
"REACTOME:R-HSA-5578775",
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361",
"REACTOME:R-RNO-2672351",
"REACTOME:R-RNO-5578775"
] | 6 | [
"1k0m",
"1k0n",
"1k0o",
"1rk4",
"2ahe",
"2d2z",
"2per",
"2r4v",
"2r5g",
"2yv7",
"2yv9",
"3fy7",
"3kjy",
"3o3t",
"3p8w",
"3p90",
"3qr6",
"3swl",
"3tgz",
"3uvh",
"4iqa",
"4jzq",
"4k0g",
"4k0n",
"5y7i",
"6ery",
"6erz",
"6y2h",
"7f8r",
"7fbq",
"8q4i",
"8q4j"... | 32 | [
"PUB00026603",
"PUB00034628",
"PUB00039284",
"PUB00040165",
"PUB00072076",
"PUB00072078",
"PUB00072099",
"PUB00072117"
] | [
"11551966",
"14613939",
"16176272",
"16581025",
"15147738",
"12202911",
"11978800",
"20085760"
] | [
"Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.",
"The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.",
"Crystal structure of the soluble form of the redox-regulated chloride ion channel prote... | [
2001,
2004,
2005,
2006,
2004,
2002,
2002,
2010
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Undibacterium luofuense"
] | [
6825,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
10,
1,
23,
12,
25
] | 6 | true | Domain | CLIC, N-terminal domain | CLIC, N-terminal domain | CLIC_N | 6 |
IPR053824 | 53,824 | Protein of unknown function DUF7010 | DUF7010 | Family | 1,282 | false | false | This entry represents a family of uncharacterised bacterial proteins. They are predicted to adopt α-helical structure composed of six up-and-down α-helices. It is likely that these proteins are associated with the membrane. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22765"
] | [
"DUF7010"
] | [
1282
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halogranum amylolyticum",
"Hemiselmis andersenii",
"ecological metagenomes"
] | [
1274,
1,
1,
6
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF7010 | Protein of unknown function DUF7010 | DUF7010 | 9 |
IPR053825 | 53,825 | Protein of unknown function DUF7009 | DUF7009 | Family | 615 | false | false | This is a family of uncharacterised proteins found in bacteria. It is predicted to adopt a globular structure consisting of two nearly orthogonal β-sheets and two α-helices that connect them. Toward the C terminus, these proteins contain a highly conserved region enriched with negatively charged residues, having nearly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22668"
] | [
"DUF7009"
] | [
615
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
606,
9
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF7009 | Protein of unknown function DUF7009 | DUF7009 | 2 |
IPR053826 | 53,826 | WD repeat-containing protein 75 | WDR75 | Family | 4,336 | true | true | This entry includes WD repeat-containing protein 75 (WDR75) from animals and its orthologues, Nan1/Utp17 (NET1-associated nuclear protein 1) from yeast. These proteins are involved in ribosome biogenesis, specifically as factors within the small subunit (SSU) processome, which is the initial precursor to the small euka... | [
"GO:0003723",
"GO:0042254",
"GO:0045943",
"GO:0032040"
] | [
"RNA binding",
"ribosome biogenesis",
"positive regulation of transcription by RNA polymerase I",
"small-subunit processome"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PANTHER"
] | [
"PTHR44215"
] | [
"SSU_processome_comp"
] | [
4336
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 5 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk"... | 46 | [
"PUB00008496",
"PUB00035837",
"PUB00090011",
"PUB00151110"
] | [
"12068309",
"15489292",
"17699751",
"34516797"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.",
"Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs i... | [
2002,
2004,
2007,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
5,
4331
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
2,
4,
9,
1,
4,
1,
1
] | 9 | true | Family | WD repeat-containing protein 75 | WD repeat-containing protein 75 | WDR75 | 5 |
IPR053827 | 53,827 | Baseplate structural protein Gp10, C-terminal domain | Gp10_C | Domain | 2,549 | false | false | This entry represents the C-terminal domain (CTD) of baseplate structural protein Gp10 that assembles into trimeric structures. The core structure and assembly of Gp10 has structural similarity to that of the head domain of Gp11 and the receptor binding domain of Gp12 [ ]. The monomeric CTD of Gp10 consists of an α-hel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21939"
] | [
"Gp10_C"
] | [
2549
] | 1 | [] | [] | [] | 0 | [
"2fkk",
"2fl8",
"2fl9",
"5hx2",
"5iv5",
"5iv7",
"7z47",
"7z4b",
"7z4f",
"9f4a",
"9f4b"
] | 11 | [
"PUB00040707",
"PUB00151773"
] | [
"16554069",
"26929357"
] | [
"Evolution of bacteriophage tails: Structure of T4 gene product 10.",
"Role of bacteriophage T4 baseplate in regulating assembly and infection."
] | [
2006,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriaceae",
"Viruses",
"metagenomes"
] | [
606,
1142,
4,
788,
9
] | 5 | [] | [] | 0 | true | Domain | Baseplate structural protein Gp10, C-terminal domain | Baseplate structural protein Gp10, C-terminal domain | Gp10_C | 9 |
IPR053828 | 53,828 | SMN1-like, C-terminal domain | SMN1-like_C | Domain | 2,583 | false | false | This entry represents the C-terminal domain found in 5'-nucleotidase SMN1 and putative Zn2-dependent 5'-nucleotidases including a nucleotidase from Candida albicans ( ) and a secreted protein ARB_01864 ( ) from Arthroderma benhamiae. This domain adopts a four-layered structure with a five-stranded β-sheet forming the s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21953"
] | [
"NadN_nucleosid_C"
] | [
2583
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.1.3.5",
"3.1.3.91",
"PWY-5381",
"PWY-5695",
"PWY-6596",
"PWY-6606",
"PWY-6607",
"PWY-6608",
"PWY-7185",
"PWY-7821"
] | [
"EC:3.1.3.5",
"EC:3.1.3.91",
"METACYC:PWY-5381",
"METACYC:PWY-5695",
"METACYC:PWY-6596",
"METACYC:PWY-6606",
"METACYC:PWY-6607",
"METACYC:PWY-6608",
"METACYC:PWY-7185",
"METACYC:PWY-7821"
] | 10 | [
"3c9f"
] | 1 | [
"PUB00163259"
] | [
"35123996"
] | [
"A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2583
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
3
] | 3 | true | Domain | SMN1-like, C-terminal domain | SMN1-like, C-terminal domain | SMN1-like_C | 1 |
IPR053829 | 53,829 | XLF-like, coiled-coil region | XLF-like_CC | Domain | 2,031 | false | false | This entry represents the coiled-coil region of Xrcc4-like factor 1 from Schizosaccharomyces pombe (XLF) and similar sequences from animals and fungi. XLF (also called Cernunnos) is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. XLF and XRCC4 form... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21928"
] | [
"XLF_CC"
] | [
2031
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5693571",
"R-MMU-5693571",
"R-RNO-5693571"
] | [
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-5693571",
"REACTOME:R-RNO-5693571"
] | 3 | [
"2qm4",
"2r9a",
"3q4f",
"3rwr",
"3sr2",
"3w03",
"7lsy",
"7lt3",
"7nfc",
"7nfe",
"7zyg",
"8bhv",
"8bhy",
"8bot",
"8eza",
"8ezb",
"9cq3",
"9cq6",
"9cqc",
"9n81",
"9n82",
"9n83"
] | 22 | [
"PUB00035487",
"PUB00035488",
"PUB00074899",
"PUB00154352"
] | [
"16439205",
"16571728",
"23442139",
"17151234"
] | [
"XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.",
"Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.",
"XRCC4 and XLF form long helical protein filaments suitable for DNA end protection a... | [
2006,
2006,
2013,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2031
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
4,
2,
1,
4,
1
] | 6 | true | Domain | XLF-like, coiled-coil region | XLF-like, coiled-coil region | XLF-like_CC | 6 |
IPR053830 | 53,830 | Domain of unknown function DUF6922 | DUF6922 | Domain | 1,405 | false | false | This domain is found in bacterial proteins either as a standalone domain or in combination with an HTH domain that resembles lambda C1 repressor DNA-binding domain. This domain has a partial sequence similarity to the RAP1 C-terminal (RCT) domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21956"
] | [
"DUF6922"
] | [
1405
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Altarchaeum hamiconexum",
"Myoviridae sp. ct7CH26",
"metagenomes"
] | [
1384,
1,
1,
19
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6922 | Domain of unknown function DUF6922 | DUF6922 | 6 |
IPR053831 | 53,831 | SOGP, N-terminal domain | SOGP_N | Domain | 916 | false | false | This entry represents the N-terminal domain of 1,2-beta oligoglucan phosphorylase (SOGP) and related bacterial proteins. This enzyme catalyses the phosphorolysis of beta-1,2-glucooligosaccharides (sophorooligosaccharides, Sops) with degrees of polymerization (DP) of 3 or more. It consists of four domains: two β-sandwic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21958"
] | [
"SOGP_N"
] | [
916
] | 1 | [] | [] | [] | 0 | [
"5h3z",
"5h40",
"5h41",
"5h42"
] | 4 | [
"PUB00151741"
] | [
"28198470"
] | [
"Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"mine drainage metagenome"
] | [
913,
2,
1
] | 3 | [] | [] | 0 | true | Domain | SOGP, N-terminal domain | SOGP, N-terminal domain | SOGP_N | 1 |
IPR053832 | 53,832 | Domain of unknown function DUF6924 | DUF6924 | Domain | 1,105 | false | false | This domain of unknown function is found in bacterial and fungal proteins, either standalone or in combination with other domains. It is probably remotely related to the anticodon binding domain observed in histidyl, glycyl, threonyl and prolyl tRNA synthetases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21962"
] | [
"DUF6924"
] | [
1105
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
805,
298,
2
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6924 | Domain of unknown function DUF6924 | DUF6924 | 8 |
IPR053833 | 53,833 | Small archaeal modifier protein 2 | SAMP2 | Family | 508 | false | false | The ubiquitin-like small archaeal modifer protein 2 (SAMP2) is involved in sulfur transfer during molybdenum cofactor biosynthesis. SAMP2 has been demonstrated to form covalent conjugates with substrate proteins through an isopeptide linkage via C-terminal di-glycine motif in a streamlined archaeal E1-dependent pathway... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21965"
] | [
"SAMP2"
] | [
508
] | 1 | [] | [] | [] | 0 | [
"2l32",
"2lji",
"4hrs"
] | 3 | [
"PUB00138937"
] | [
"23821306"
] | [
"Crystal structure of the ubiquitin-like small archaeal modifier protein 2 from Haloferax volcanii."
] | [
2013
] | 1 | [] | [
"IPR053834"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
487,
16,
5
] | 3 | [] | [] | 0 | true | Family | Small archaeal modifier protein 2 | Small archaeal modifier protein 2 | SAMP2 | 5 |
IPR053834 | 53,834 | Ubiquitin-like small modifier protein 2, halobacteria | SAMP2_halobacteria | Family | 309 | false | false | This family of proteins is involved in post-translational modification of substrate proteins through a process known as sampylation [ , ]. Members of this family function by covalently attaching to lysine residues on target proteins via an isopeptide bond formed with the C-terminal glycine carboxylate of the modifier p... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF041919"
] | [
"SAMP2"
] | [
309
] | 1 | [] | [] | [] | 0 | [
"2l32",
"2lji",
"4hrs"
] | 3 | [
"PUB00058155",
"PUB00138937"
] | [
"20054389",
"23821306"
] | [
"Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii.",
"Crystal structure of the ubiquitin-like small archaeal modifier protein 2 from Haloferax volcanii."
] | [
2010,
2013
] | 2 | [
"IPR053833"
] | [] | 1 | 0 | 1 | [
"Methanobacteriota"
] | [
309
] | 1 | [] | [] | 0 | true | Family | Ubiquitin-like small modifier protein 2, halobacteria | Ubiquitin-like small modifier protein 2, halobacteria | SAMP2_halobacteria | 4 |
IPR053835 | 53,835 | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix | ASH2L-like_WH | Domain | 2,325 | false | false | This domain is found in Set1/Ash2 histone methyltransferase complex subunit ASH2 from humans (ASH2L, named after 'Absent, small, homeotic disks-2-like') and similar animal proteins. ASH2L is a non-catalytic component of the Set1/Ash2 histone methyltransferase (HMT) complex. Aberrant expression and recurrent recurrent m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21198"
] | [
"ASH2L-like_WH"
] | [
2325
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-3214841",
"R-CEL-8936459",
"R-CEL-9772755",
"R-DME-201722",
"R-DME-8936459",
"R-DME-9772755",
"R-HSA-201722",
"R-HSA-3214841",
"R-HSA-3769402",
"R-HSA-5617472",
"R-HSA-8936459",
"R-HSA-9772755",
"R-HSA-9818564",
"R-HSA-9841922",
"R-HSA-9944997",
"R-MMU-201722",
"R-MMU-3214841"... | [
"REACTOME:R-CEL-3214841",
"REACTOME:R-CEL-8936459",
"REACTOME:R-CEL-9772755",
"REACTOME:R-DME-201722",
"REACTOME:R-DME-8936459",
"REACTOME:R-DME-9772755",
"REACTOME:R-HSA-201722",
"REACTOME:R-HSA-3214841",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-5617472",
"REACTOME:R-HSA-8936459",
"REACTOME:... | 22 | [
"3rsn",
"3s32",
"6kiu",
"6kiv",
"6kiw",
"6kix",
"6kiz",
"6pwv",
"6w5i",
"6w5m",
"6w5n",
"7mbm",
"7mbn",
"7ud5"
] | 14 | [
"PUB00065627",
"PUB00065656",
"PUB00109487",
"PUB00152666"
] | [
"21642971",
"21660059",
"31804488",
"31485071"
] | [
"Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.",
"Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.",
"Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.",
"Structural basis ... | [
2011,
2011,
2019,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2325
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
2,
1,
4,
8,
5,
1
] | 7 | true | Domain | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix | ASH2L-like_WH | 1 |
IPR053836 | 53,836 | Nuclear-export cofactor Arc1-like, N-terminal domain | Arc1-like_N | Domain | 4,440 | false | false | This entry represents a domain found N-terminal in the nuclear-export cofactor Arc1 (Arc1-N) from yeast and related proteins. Arc1-N and GluRS-N are known to be necessary and sufficient for formation of the yeast aaRS complex in vivo and in vitro. They are likely to form a stable complex with each other. Arc1-N adopts ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21972"
] | [
"Arc1p_N_like"
] | [
4440
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-156842",
"R-HSA-2408522",
"R-HSA-379716",
"R-HSA-6782315",
"R-HSA-9856649",
"R-MMU-9856649",
"R-SCE-156842"
] | [
"REACTOME:R-DME-156842",
"REACTOME:R-HSA-2408522",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-9856649",
"REACTOME:R-SCE-156842"
] | 7 | [
"2hqt",
"2hrk",
"2hsm",
"2hsn",
"2uz8",
"4bl7",
"4bvx",
"4bvy",
"5a1n",
"5a34",
"5a5h",
"5bmu",
"5dqs",
"5y6l",
"5zke",
"5zkf",
"5zkh",
"6iy6",
"6jre"
] | 19 | [
"PUB00041479",
"PUB00049517",
"PUB00154354",
"PUB00154355",
"PUB00154356"
] | [
"17139087",
"18343821",
"24100331",
"29576217",
"3290852"
] | [
"Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.",
"Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM."... | [
2006,
2008,
2013,
2018,
1988
] | 5 | [] | [
"IPR053837"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
119,
4319,
2
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
1,
4,
9,
9,
1,
3,
4,
2,
1,
4
] | 11 | true | Domain | Nuclear-export cofactor Arc1-like, N-terminal domain | Nuclear-export cofactor Arc1-like, N-terminal domain | Arc1-like_N | 9 |
IPR053838 | 53,838 | Protein of unknown function DUF6925 | DUF6925 | Family | 358 | false | false | This is a family of uncharacterised bacterial proteins. They are probably distantly related to heme-binding proteins PhuS, ChuS, HmuS. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21973"
] | [
"DUF6925"
] | [
358
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nitrosocaldus cavascurensis",
"metagenomes"
] | [
355,
1,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF6925 | Protein of unknown function DUF6925 | DUF6925 | 7 |
IPR053839 | 53,839 | Domain of unknown function DUF6926 | DUF6926 | Domain | 275 | false | false | This domain of unknown function is found in bacterial proteins. It is probably distantly related to dodecin. It is predicted to adopt a simple fold consisting of a core of 3 β-strands, forming a curved β-sheet, and two short α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21977"
] | [
"DUF6926"
] | [
275
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"unclassified sequences"
] | [
262,
7,
6
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6926 | Domain of unknown function DUF6926 | DUF6926 | 4 |
IPR053840 | 53,840 | Hfq-related | Hfq_1 | Domain | 351 | false | false | Hfq proteins participate in RNA folding and translational regulation through pairing of small RNAs and messenger RNAs. Hfq proteins share the distinctive Sm fold, and form ring-shaped structures similar to those of the Sm/Lsm proteins regulating mRNA turnover in eukaryotes. This entry represents Hfq-related proteins fo... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047718",
"PF21979"
] | [
"Hfq_rel_Cyano",
"Hfq_1"
] | [
316,
351
] | 2 | [] | [] | [] | 0 | [
"3hfn",
"3hfo"
] | 2 | [
"PUB00154002",
"PUB00154003"
] | [
"19777643",
"31076551"
] | [
"Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties.",
"<i>Caulobacter crescentus</i> Hfq structure reveals a conserved mechanism of RNA annealing regulation."
] | [
2009,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"unclassified sequences"
] | [
342,
6,
3
] | 3 | [] | [] | 0 | true | Domain | Hfq-related | Hfq-related | Hfq_1 | 2 |
IPR053841 | 53,841 | Condensin complex protein MksE | MksE | Family | 1,880 | false | false | This entry represents a small family of MksE proteins. These proteins are part of MksBEF complex, which primarily function in structural chromosome maintenance [ ]. The N-terminal part of MksE is remotely related to the chromosome partition protein MukE and most likely adopts the same structure that consists of two win... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21980"
] | [
"MksE"
] | [
1880
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00052876",
"PUB00106028"
] | [
"19135891",
"35072315"
] | [
"Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions.",
"Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs."
] | [
2009,
2022
] | 2 | [] | [
"IPR047723"
] | 0 | 1 | 0 | [
"Bacteria",
"metagenomes"
] | [
1866,
14
] | 2 | [] | [] | 0 | true | Family | Condensin complex protein MksE | Condensin complex protein MksE | MksE | 2 |
IPR053842 | 53,842 | Mobilization protein NikA-like | NikA-like | Family | 14,679 | false | false | This family includes homologues of mobilisation protein NikA, such as protein TraJ as well as MobC, MobB and MobA. These proteins are involved in mobilisation and replication functions of plasmids. They are distantly related to accessory factor PcfF and likely adopt similar homo-dimeric structure consisting of N-termin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21983"
] | [
"NikA-like"
] | [
14679
] | 1 | [] | [] | [] | 0 | [
"2ba3"
] | 1 | [] | [] | [] | [] | 0 | [] | [
"IPR047751",
"IPR049793"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
26,
14348,
8,
10,
8,
279
] | 6 | [] | [] | 0 | true | Family | Mobilization protein NikA-like | Mobilization protein NikA-like | NikA-like | 5 |
IPR053843 | 53,843 | DnaD, N-terminal domain | DnaD_N | Domain | 3,065 | false | false | DnaD is a primosomal protein that remodels supercoiled plasmids. It binds to supercoiled forms and converts them to open forms without nicking. The DnaD N-terminal domain has a scaffold-forming activity. This domain adopts a classical winged helix fold decorated with extensions at both termini [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21984"
] | [
"DnaD_N"
] | [
3065
] | 1 | [] | [] | [] | 0 | [
"2v79",
"2vn2",
"3r0a",
"8ojj"
] | 4 | [
"PUB00049610",
"PUB00061015"
] | [
"18206906",
"18703019"
] | [
"Structure of the N-terminal oligomerization domain of DnaD reveals a unique tetramerization motif and provides insights into scaffold formation.",
"Crystal structure of the N-terminal domain of Geobacillus kaustophilus HTA426 DnaD protein."
] | [
2008,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanosarcinaceae",
"Phytophthora kernoviae 00238/432",
"Sepvirinae",
"metagenomes"
] | [
3002,
53,
1,
3,
6
] | 5 | [] | [] | 0 | true | Domain | DnaD, N-terminal domain | DnaD, N-terminal domain | DnaD_N | 9 |
IPR053844 | 53,844 | Allophanate hydrolase, C-terminal domain | AH_C | Domain | 6,034 | false | false | Allophanate hydrolase (AH) converts allophanate to ammonium and carbon dioxide. The AH structure is composed of N- and C-terminal domains. These domains catalyse sequential reactions: the N-terminal domain converts allophanate to N-carboxycarbamate, whereas the C-terminal domain converts it to carbon dioxide and ammoni... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21986"
] | [
"AH_C"
] | [
6034
] | 1 | [
"EC"
] | [
"3.5.1.54"
] | [
"EC:3.5.1.54"
] | 1 | [
"4gyr",
"4gys",
"4iss",
"4ist",
"5c5z",
"5i8i"
] | 6 | [
"PUB00153798",
"PUB00153799",
"PUB00153800",
"PUB00153801"
] | [
"23754281",
"23282241",
"26249697",
"29263142"
] | [
"Structure and function of allophanate hydrolase.",
"The structure of allophanate hydrolase from Granulibacter bethesdensis provides insights into substrate specificity in the amidase signature family.",
"Crystal structure analysis of c4763, a uropathogenic Escherichia coli-specific protein.",
"Structure and ... | [
2013,
2013,
2015,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"metagenomes"
] | [
5481,
522,
2,
29
] | 4 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Allophanate hydrolase, C-terminal domain | Allophanate hydrolase, C-terminal domain | AH_C | 6 |
IPR053846 | 53,846 | Histidyl-tRNA synthetase HisZ, C-terminal domain, Bacillales | HisZ_C_Bacillales | Domain | 598 | false | false | This entry represents the C-terminal domain of HisZ mainly found in Bacillales. This is the anticodon binding domain, which consists of three-stranded parallel β-sheet flanked on each side with α-helices. HisZ is a regulatory subunit of the heteromeric ATP phosphoribosyl transferase that regulates reactions initiating ... | [
"GO:0004821",
"GO:0006427"
] | [
"histidine-tRNA ligase activity",
"histidyl-tRNA aminoacylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF21996"
] | [
"HisZ-like"
] | [
598
] | 1 | [] | [] | [] | 0 | [
"3od1"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
598
] | 1 | [] | [] | 0 | true | Domain | Histidyl-tRNA synthetase HisZ, C-terminal domain, Bacillales | Histidyl-tRNA synthetase HisZ, C-terminal domain, Bacillales | HisZ_C_Bacillales | 3 |
IPR053847 | 53,847 | Protein of unknown function DUF6928 | DUF6928 | Family | 960 | false | false | This is a family of uncharacterised bacterial proteins. They are predicted to adopt an α/β structure with a central nine-stranded antiparallel β-sheet with α-helices packed on both sides. The predicted structure has some partial structural similarity to bacterial S-adenosylmethionine decarboxylases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21997"
] | [
"DUF6928"
] | [
960
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Didymella rabiei",
"freshwater metagenome"
] | [
958,
1,
1
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF6928 | Protein of unknown function DUF6928 | DUF6928 | 8 |
IPR053848 | 53,848 | DNA polymerase IV/DNA polymerase iota-like, thumb domain | IMS_HHH_1 | Domain | 19,428 | false | false | This entry represents the thumb domain found in DNA polymerase iota and related proteins such as members of the eukaryotic Y-family DNA polymerases, like DNA repair protein REV1, as well as bacterial Pol IV. This domain makes contacts with the minor groove of DNA [ , ]. Y-family polymerases are characterised by their l... | [
"GO:0003887"
] | [
"DNA-directed DNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF21999"
] | [
"IMS_HHH_1"
] | [
19428
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.7",
"R-DME-110312",
"R-DME-5655862",
"R-DME-5656121",
"R-GGA-353503",
"R-HSA-110312",
"R-HSA-5655862",
"R-HSA-5656121",
"R-HSA-5656169",
"R-MMU-110312",
"R-MMU-5655862",
"R-MMU-5656121",
"R-MMU-5656169",
"R-SCE-110312",
"R-SCE-5655862",
"R-SCE-5656121",
"R-SCE-5656169",
"R-S... | [
"EC:2.7.7.7",
"REACTOME:R-DME-110312",
"REACTOME:R-DME-5655862",
"REACTOME:R-DME-5656121",
"REACTOME:R-GGA-353503",
"REACTOME:R-HSA-110312",
"REACTOME:R-HSA-5655862",
"REACTOME:R-HSA-5656121",
"REACTOME:R-HSA-5656169",
"REACTOME:R-MMU-110312",
"REACTOME:R-MMU-5655862",
"REACTOME:R-MMU-5656121"... | 21 | [
"1t3n",
"1zet",
"2alz",
"2aq4",
"2dpi",
"2dpj",
"2fll",
"2fln",
"2flp",
"3bjy",
"3epg",
"3epi",
"3g6v",
"3g6x",
"3g6y",
"3gqc",
"3gv5",
"3gv7",
"3gv8",
"3h40",
"3h4b",
"3h4d",
"3ngd",
"3osn",
"3osp",
"3q8p",
"3q8q",
"3q8r",
"3q8s",
"4dez",
"4ebc",
"4ebd"... | 106 | [
"PUB00031316",
"PUB00039330",
"PUB00039363",
"PUB00040279",
"PUB00052982",
"PUB00053994",
"PUB00053995",
"PUB00053996",
"PUB00053997",
"PUB00053998",
"PUB00154357"
] | [
"15254543",
"16216587",
"16195463",
"16819516",
"19464298",
"9391106",
"11080171",
"11463382",
"11751576",
"12060704",
"15916957"
] | [
"Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.",
"Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair.",
"Rev1 employs a novel mechanism of DNA synthesis using a protein template.",
"Hoogsteen base pair formation promotes synthesis oppos... | [
2004,
2005,
2005,
2006,
2009,
1997,
2000,
2001,
2002,
2002,
2005
] | 11 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
165,
13390,
5678,
6,
189
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
1,
15,
1,
1,
6,
10,
1,
4,
10,
1,
1,
13
] | 13 | true | Domain | DNA polymerase IV/DNA polymerase iota-like, thumb domain | DNA polymerase IV/DNA polymerase iota-like, thumb domain | IMS_HHH_1 | 9 |
IPR053849 | 53,849 | DUF5817, C-terminal domain | DUF5817_C | Domain | 326 | false | false | This entry represents a helix-turn-helix (HTH) domain found in a group of functionally uncharacterised archaeal proteins, typically associated with the DUF5817 ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22798"
] | [
"DUF5817_CT"
] | [
326
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
326
] | 1 | [] | [] | 0 | true | Domain | DUF5817, C-terminal domain | DUF5817, C-terminal domain | DUF5817_C | 4 |
IPR053850 | 53,850 | Glycoside hydrolase 123, N-terminal domain | Glyco_hydro_123_N_2 | Domain | 1,274 | false | false | This entry represents the N-terminal domain of a group of glycoside hydrolases 123, from bacteria [ , ], including N-acetylgalactosaminidase from Clostridium perfringens. This enzyme removes specific terminal N-D-acetylgalactosamine from glycosphingolipids. This domain folds into a twisted β-sandwich that consists of t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22680"
] | [
"Glyco_hydro_123_N_2"
] | [
1274
] | 1 | [] | [] | [] | 0 | [
"5fqe",
"5fqf",
"5fqg",
"5fqh",
"5fr0",
"5l7r",
"5l7u",
"5l7v",
"8k2f",
"8k2g",
"8k2j",
"8k2k"
] | 12 | [
"PUB00100654",
"PUB00151590"
] | [
"27038508",
"27546776"
] | [
"The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens.",
"Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation."
] | [
2016,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"Viridiplantae",
"unclassified sequences"
] | [
1220,
2,
9,
43
] | 4 | [] | [] | 0 | true | Domain | Glycoside hydrolase 123, N-terminal domain | Glycoside hydrolase 123, N-terminal domain | Glyco_hydro_123_N_2 | 3 |
IPR053852 | 53,852 | Protein of unknown function DUF6910 | DUF6910 | Family | 111 | false | false | The function of this family of proteins is unknown. They are predicted to adopt a five-bladed β-propeller and are probably distantly related to apyrase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21851"
] | [
"DUF6910"
] | [
111
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thecamonas trahens ATCC 50062"
] | [
110,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF6910 | Protein of unknown function DUF6910 | DUF6910 | 9 |
IPR053853 | 53,853 | Antitoxin FitA-like, ribbon-helix-helix | FitA-like_RHH | Domain | 5,350 | false | false | This is the ribbon-helix-helix (RHH) motif found in antitoxin FitA from Neisseria gonorrhoeae and similar bacterial sequences, such as the putative antitoxin VapB12/VapB14 and VapB1 from Mycobacterium tuberculosis [ ]. FitA is the antitoxin component of a type II toxin-antitoxin (TA) system. It binds DNA through its ri... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22513"
] | [
"FitA-like_RHH"
] | [
5350
] | 1 | [] | [] | [] | 0 | [
"2bsq",
"2h1o",
"7e4j"
] | 3 | [
"PUB00039746",
"PUB00056596"
] | [
"16982615",
"15718296"
] | [
"Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.",
"Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes."
] | [
2006,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloarcula tailed virus 3",
"metagenomes"
] | [
5251,
4,
1,
94
] | 4 | [] | [] | 0 | true | Domain | Antitoxin FitA-like, ribbon-helix-helix | Antitoxin FitA-like, ribbon-helix-helix | FitA-like_RHH | 8 |
IPR053854 | 53,854 | Domain of unknown function DUF7018 | DUF7018 | Domain | 461 | false | false | This entry represents a domain of unknown function predominantly found in protein sequences from Bacillus. Many members of this group show this domain at the N-terminal and DUF3994 ( ) at the C-terminal. According to structure predictions, this domain consists of α-helices, suggesting it is the membrane spanning region... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22872"
] | [
"DUF7018"
] | [
461
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Methanobacterium subterraneum",
"marine sediment metagenome"
] | [
459,
1,
1
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7018 | Domain of unknown function DUF7018 | DUF7018 | 5 |
IPR053855 | 53,855 | Protein of unknown function DUF6931 | DUF6931 | Family | 950 | false | false | This is a family of uncharacterised bacterial proteins. They share significant sequence similarity with immunity protein Imm5 ( ) and are predicted to adopt similar α-helical structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22011"
] | [
"DUF6931"
] | [
950
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"ecological metagenomes"
] | [
943,
7
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF6931 | Protein of unknown function DUF6931 | DUF6931 | 5 |
IPR053856 | 53,856 | Cytokine receptor-like factor 2-like, domain 1 | TSLPR_D1 | Domain | 743 | false | false | Cytokine receptor-like factor 2 also known as TSLPR is a receptor for thymic stromal lymphopoietin. It contains two ectodomains with Ig-like topology. This family represents the first of these domains. This entry also includes cytokine receptor common subunit gamma, also known as IL2RG, that is known to bind with low a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22012"
] | [
"TSLPR_D1"
] | [
743
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1266695",
"R-BTA-5673001",
"R-BTA-6785807",
"R-BTA-8983432",
"R-BTA-8985947",
"R-BTA-9020558",
"R-BTA-9020958",
"R-BTA-912526",
"R-HSA-1266695",
"R-HSA-5673001",
"R-HSA-6785807",
"R-HSA-8983432",
"R-HSA-8985947",
"R-HSA-9020558",
"R-HSA-9020958",
"R-HSA-912526",
"R-HSA-9701898... | [
"REACTOME:R-BTA-1266695",
"REACTOME:R-BTA-5673001",
"REACTOME:R-BTA-6785807",
"REACTOME:R-BTA-8983432",
"REACTOME:R-BTA-8985947",
"REACTOME:R-BTA-9020558",
"REACTOME:R-BTA-9020958",
"REACTOME:R-BTA-912526",
"REACTOME:R-HSA-1266695",
"REACTOME:R-HSA-5673001",
"REACTOME:R-HSA-6785807",
"REACTOME... | 25 | [
"2b5i",
"2erj",
"3bpl",
"3qaz",
"3qb7",
"4gs7",
"4nn5",
"4nn6",
"4nn7",
"5j11",
"5j12",
"5m5e",
"6dg5",
"6oel",
"7s2r",
"8ent",
"8epa",
"9e2t",
"9jqt"
] | 19 | [
"PUB00039525",
"PUB00040414",
"PUB00050720",
"PUB00065568"
] | [
"16293754",
"16477002",
"18243101",
"22446627"
] | [
"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.",
"Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.",
"Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.",
"Exploiting... | [
2005,
2006,
2008,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
743
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
8,
14
] | 3 | true | Domain | Cytokine receptor-like factor 2-like, domain 1 | Cytokine receptor-like factor 2-like, domain 1 | TSLPR_D1 | 2 |
IPR053857 | 53,857 | CRISPR system endoribonuclease Csx1, CARF domain | Csx1_CARF | Domain | 296 | false | false | CRISPR system endoribonuclease Csx1 is a metal-independent, endoribonuclease that acts selectively on ssRNA and cleaves specifically after adenosines, as part of the type III-B CRISP-Cas system, and is homologous to Csm6 [ , , ], sharing the same domain domain architecture consisting of a CARF domain at the N-terminal ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22230"
] | [
"Csx1_CARF"
] | [
296
] | 1 | [] | [] | [] | 0 | [
"2i71",
"4eog",
"6o6s",
"6o6t",
"6o6v",
"6o6x",
"6o6y",
"6o6z",
"6o70",
"6o71",
"6ov0",
"6qzq",
"6qzt",
"6r7b",
"6r9r"
] | 15 | [
"PUB00020781",
"PUB00153854",
"PUB00153894"
] | [
"16292354",
"26763118",
"26647461"
] | [
"A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.",
"Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6.",
"The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific end... | [
2005,
2016,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria"
] | [
224,
72
] | 2 | [] | [] | 0 | true | Domain | CRISPR system endoribonuclease Csx1, CARF domain | CRISPR system endoribonuclease Csx1, CARF domain | Csx1_CARF | 8 |
IPR053858 | 53,858 | Arb2 domain | Arb2_dom | Domain | 4,491 | false | false | This entry represents Arb2 domain that was first described in Argonaute-binding protein 2 from S. pombe, from which it gets the name. Arb2 protein is the orthologue of FAM172 from animals, including FAM12A from human, a protein associated with CHARGE syndrome, a severe multi-organ developmental disorder mainly affectin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22749"
] | [
"Arb2"
] | [
4491
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044153",
"PUB00090322",
"PUB00151888"
] | [
"17310250",
"29311329",
"37221016"
] | [
"Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast.",
"Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.",
"The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import."
] | [
2007,
2018,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4491
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
10,
1,
6,
8,
1,
5,
1
] | 8 | true | Domain | Arb2 domain | Arb2 domain | Arb2_dom | 9 |
IPR053859 | 53,859 | Diphosphomevalonate decarboxylase-like N-terminal domain | MVD-like_N | Domain | 9,340 | false | false | This entry represents the N-terminal domain of Diphosphomevalonate decarboxylases [ , , ] which catalyse the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Members of this entry function in the mevalonate pathway leading to isopentenyl diphosphate (IPP), a key precurso... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22700"
] | [
"MVD-like_N"
] | [
9340
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.1.33",
"PWY-7391",
"PWY-922",
"R-BTA-191273",
"R-BTA-446199",
"R-DDI-191273",
"R-DDI-446199",
"R-DRE-191273",
"R-DRE-446199",
"R-HSA-191273",
"R-HSA-2426168",
"R-HSA-446199",
"R-MMU-191273",
"R-MMU-446199",
"R-RNO-191273",
"R-RNO-446199",
"R-SCE-191273",
"R-SCE-446199",
"R-S... | [
"EC:4.1.1.33",
"METACYC:PWY-7391",
"METACYC:PWY-922",
"REACTOME:R-BTA-191273",
"REACTOME:R-BTA-446199",
"REACTOME:R-DDI-191273",
"REACTOME:R-DDI-446199",
"REACTOME:R-DRE-191273",
"REACTOME:R-DRE-446199",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-446199",
"REACTOME:R-... | 20 | [
"1fi4",
"2gs8",
"2hk2",
"2hk3",
"2hke",
"3d4j",
"3f0n",
"3lto",
"3qt5",
"3qt6",
"3qt7",
"3qt8",
"4dpt",
"4dpu",
"4dpw",
"4dpx",
"4dpy",
"4du7",
"4du8",
"4rkp",
"4rks",
"4rkz",
"4z7c",
"4z7y",
"5gmd",
"5gme",
"5v2l",
"5v2m",
"6e2s",
"6e2t",
"6e2u",
"6e2v"... | 40 | [
"PUB00041428",
"PUB00051244",
"PUB00057027",
"PUB00060991",
"PUB00106018"
] | [
"17583736",
"18823933",
"21561869",
"22734632",
"25636853"
] | [
"Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity.",
"Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.",
"... | [
2007,
2008,
2011,
2012,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
454,
4098,
4751,
37
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
1,
1,
4,
3,
1,
6,
6,
1,
1,
22
] | 12 | true | Domain | Diphosphomevalonate decarboxylase-like N-terminal domain | Diphosphomevalonate decarboxylase-like N-terminal domain | MVD-like_N | 4 |
IPR053860 | 53,860 | Protein of unknown function DUF6932 | DUF6932 | Family | 1,127 | false | false | This is a family of uncharacterised bacterial proteins. They are remotely related to nucleotidyltransferases ( ) and share similar active site architecture. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22014"
] | [
"DUF6932"
] | [
1127
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Tanacetum cinerariifolium",
"Viruses",
"metagenomes"
] | [
1091,
14,
1,
5,
16
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function DUF6932 | Protein of unknown function DUF6932 | DUF6932 | 1 |
IPR053861 | 53,861 | Bacteriophage Mu Gp45, N-terminal | Phage_Mu_Gp45_N | Domain | 2,183 | false | false | This entry represents the N-terminal domain of Gp45 and similar sequences. This domain may adopt a OB-like β-barrel fold. This entry includes Gp45 from bacteriophage Mu. Gp45 is a component of the baseplate that forms a central needlelike spike used to puncture the host cell membrane for tube insertion during virus ent... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF06890"
] | [
"Phage_Mu_Gp45"
] | [
2183
] | 1 | [] | [] | [] | 0 | [
"9ki1"
] | 1 | [
"PUB00065189",
"PUB00077063"
] | [
"22922659",
"20478417"
] | [
"Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion.",
"The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein."
] | [
2013,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
2146,
17,
9,
11
] | 4 | [] | [] | 0 | true | Domain | Bacteriophage Mu Gp45, N-terminal | Bacteriophage Mu Gp45, N-terminal | Phage_Mu_Gp45_N | 6 |
IPR053863 | 53,863 | Glyoxalase/Bleomycin resistance-like, N-terminal | Glyoxy/Ble-like_N | Domain | 5,294 | false | false | This entry represents the N-terminal glyoxalase-like domain found in a group of proteins from bacteria, archaea and fungi, related to glyoxalase and bleomycin resistance proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22677"
] | [
"Ble-like_N"
] | [
5294
] | 1 | [] | [] | [] | 0 | [
"2r6u",
"4gym",
"4mym",
"4pav"
] | 4 | [
"PUB00005214",
"PUB00021496",
"PUB00022487",
"PUB00051656",
"PUB00064041"
] | [
"7481800",
"11134052",
"15028678",
"18826259",
"23066739"
] | [
"Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad.",
"Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin.",
"Crystallographic comparison of manganese- and iron-dependent homoprotocatechuate 2... | [
1995,
2001,
2004,
2008,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
99,
5011,
157,
27
] | 4 | [] | [] | 0 | true | Domain | Glyoxalase/Bleomycin resistance-like, N-terminal | Glyoxalase/Bleomycin resistance-like, N-terminal | Glyoxy/Ble-like_N | 8 |
IPR053864 | 53,864 | Domain of unknown function DUF6933 | DUF6933 | Domain | 1,395 | false | false | This domain is found mainly in bacterial uncharacterised proteins. It is typically between 150 and 160 amino acids in length. It is remotely related to ribonuclease H-like nucleases but it is unlikely to possess any enzymatic activity. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22016"
] | [
"DUF6933"
] | [
1395
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"candidate division MSBL1 archaeon SCGC-AAA382A20",
"ecological metagenomes"
] | [
1385,
1,
9
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6933 | Domain of unknown function DUF6933 | DUF6933 | 1 |
IPR053865 | 53,865 | Protein of unknown function DUF6934 | DUF6934 | Family | 638 | false | false | This is a family of uncharacterised bacterial proteins. They are predicted to adopt an α/β structure consisting of a central mixed β-sheet packed on both sides with α-helices that is reminiscent to the common structural core of N-acetyltransferases (NAT). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22028"
] | [
"DUF6934"
] | [
638
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"mine drainage metagenome"
] | [
637,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF6934 | Protein of unknown function DUF6934 | DUF6934 | 1 |
IPR053866 | 53,866 | PhyR, sigma2 domain | PhyR_sigma2 | Domain | 6,231 | false | false | This entry represents the N-terminal domain of the signal transduction response regulator PhyR and related bacterial proteins. It consists of three α-helices and together with sigma4 domain ( ), it constitutes the PhyR N-terminal sigma-like (SL) domain [ , ]. This domain was shown to bind to anti-sigma factor NepR [ , ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22029"
] | [
"PhyR_sigma2"
] | [
6231
] | 1 | [] | [] | [] | 0 | [
"2lfw",
"3n0r",
"3t0y",
"4g97",
"4qic",
"5uxv",
"5uxw",
"9by5",
"9cb6"
] | 9 | [
"PUB00059649",
"PUB00065681",
"PUB00143771"
] | [
"22550171",
"22550172",
"20735776"
] | [
"Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria.",
"Structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria.",
"A structural model of anti-anti-σ inhibition by a two-component receiver domain: the PhyR stress re... | [
2012,
2012,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6209,
3,
19
] | 3 | [] | [] | 0 | true | Domain | PhyR, sigma2 domain | PhyR, sigma2 domain | PhyR_sigma2 | 8 |
IPR053867 | 53,867 | PhyR, sigma4 domain | PhyR_sigma4 | Domain | 2,383 | false | false | This entry represents a domain of PhyR, a signal transduction response regulator, and related proteins found mainly in Alphaproteobacteria. PhyR contains a C-terminal receiver domain ( ) and extracytoplasmic function (ECF) σ-like (SL) domain at the N terminus. The SL domain consists of sigma2 and sigma4 subdomains with... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22233"
] | [
"PhyR_sigma-like"
] | [
2383
] | 1 | [] | [] | [] | 0 | [
"2lfw",
"3n0r",
"3t0y",
"4g97",
"4qic",
"5uxv",
"5uxw",
"9by5",
"9cb6"
] | 9 | [
"PUB00059649",
"PUB00065681",
"PUB00143771"
] | [
"22550171",
"22550172",
"20735776"
] | [
"Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria.",
"Structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria.",
"A structural model of anti-anti-σ inhibition by a two-component receiver domain: the PhyR stress re... | [
2012,
2012,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctTBd21",
"ecological metagenomes"
] | [
2370,
3,
1,
9
] | 4 | [] | [] | 0 | true | Domain | PhyR, sigma4 domain | PhyR, sigma4 domain | PhyR_sigma4 | 3 |
IPR053868 | 53,868 | Pel9A-like, right handed beta-helix region | Pel9A-like_beta_helix | Domain | 5,581 | false | false | This region is found in Pectate lyase L from Erwinia chrysanthemi (Pel9A) and similar bacterial and fungal proteins. Pel9A shows endo-cleaving activity on polygalacturonate or partially methylated pectin and has an important role in soft-rot disease. This region forms a parallel β-helix domain [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22842"
] | [
"Pel9A-like_beta_helix"
] | [
5581
] | 1 | [
"EC"
] | [
"4.2.2.2"
] | [
"EC:4.2.2.2"
] | 1 | [
"1ru4",
"5olq",
"5olr",
"5ols",
"6kfn"
] | 5 | [
"PUB00022631"
] | [
"14670977"
] | [
"The crystal structure of pectate lyase Pel9A from Erwinia chrysanthemi."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
4836,
675,
35,
35
] | 4 | [] | [] | 0 | true | Domain | Pel9A-like, right handed beta-helix region | Pel9A-like, right handed beta-helix region | Pel9A-like_beta_helix | 7 |
IPR053869 | 53,869 | C5a peptidase, third Fn3 domain | ScpA_Fn3_3rd | Domain | 71 | false | false | This is the third Fn3 domain found at C5a peptidase from Streptococcus pyogenes (ScpA) and similar sequences from firmicutes. ScpA is a multidomain cell-envelope subtilase that cleaves complement component C5a. This protein consists of a catalytic domain ( ) with an inserted PA domain ( ) and and three tandemly arrange... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22143"
] | [
"ScpA_C"
] | [
71
] | 1 | [
"EC"
] | [
"3.4.21.110"
] | [
"EC:3.4.21.110"
] | 1 | [
"1xf1",
"3eif",
"7bj3",
"7yzx",
"8bty"
] | 5 | [
"PUB00046871",
"PUB00051703",
"PUB00154226"
] | [
"16344483",
"19152799",
"33897974"
] | [
"Structure of the streptococcal cell wall C5a peptidase.",
"Model for substrate interactions in C5a peptidase from Streptococcus pyogenes: A 1.9 A crystal structure of the active form of ScpA.",
"Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a ... | [
2005,
2009,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Streptococcus"
] | [
71
] | 1 | [] | [] | 0 | true | Domain | C5a peptidase, third Fn3 domain | C5a peptidase, third Fn3 domain | ScpA_Fn3_3rd | 2 |
IPR053870 | 53,870 | TiaS-like, TCKD domain | TiaS-like_TCKD | Domain | 1,254 | false | false | This is the TCKD domain found in tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS and related proteins. TiaS is an ATP-dependent agmatine transferase that catalyses the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2) [ ]. It consists of four domains, the TCKD domain at the N-terminal f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22641"
] | [
"TiaS_TCKD"
] | [
1254
] | 1 | [
"EC"
] | [
"6.3.4.22"
] | [
"EC:6.3.4.22"
] | 1 | [
"3amt",
"3amu",
"3au7",
"3u02",
"4rvz",
"5xob",
"6agg"
] | 7 | [
"PUB00106019",
"PUB00154283"
] | [
"30121296",
"22002223"
] | [
"Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon.",
"Structural basis of tRNA agmatinylation essential for AUA codon decoding."
] | [
2018,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Geodia barretti",
"Microgenomates group",
"unclassified sequences"
] | [
1205,
1,
4,
44
] | 4 | [] | [] | 0 | true | Domain | TiaS-like, TCKD domain | TiaS-like, TCKD domain | TiaS-like_TCKD | 4 |
IPR053871 | 53,871 | CATSPERG, beta-propeller domain | CATSPERG_beta-prop | Domain | 667 | false | false | This entry represents the β-propeller domain of the gamma subunit (CATSPERG) [ ]. The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 that functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactiv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15064"
] | [
"CATSPERG_beta-prop"
] | [
667
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00067742",
"PUB00100197",
"PUB00152447"
] | [
"21224844",
"19516020",
"34225353",
"22285849"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",
"Structure of a mammalian sperm cation channel complex.",
"Nongenomic actions of aldosterone and progesterone rev... | [
2011,
2009,
2021,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
667
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
5,
3
] | 3 | true | Domain | CATSPERG, beta-propeller domain | CATSPERG, beta-propeller domain | CATSPERG_beta-prop | 6 |
IPR053872 | 53,872 | CATSPERG, N-terminal domain | CATSPERG_N | Domain | 617 | false | false | This entry represents the N-terminal domain of the gamma subunit (CATSPERG) [ ]. The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 that functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactiva... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22840"
] | [
"CATSPERG_NTD"
] | [
617
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00067742",
"PUB00100197",
"PUB00152447"
] | [
"21224844",
"19516020",
"34225353",
"22285849"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",
"Structure of a mammalian sperm cation channel complex.",
"Nongenomic actions of aldosterone and progesterone rev... | [
2011,
2009,
2021,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
617
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
6,
2
] | 3 | true | Domain | CATSPERG, N-terminal domain | CATSPERG, N-terminal domain | CATSPERG_N | 8 |
IPR053873 | 53,873 | CATSPERG, C-terminal domain | CATSPERG_C | Domain | 670 | false | false | This entry represents the C-terminal domain of the gamma subunit (CATSPERG), which covers the Stem domain and the transmembrane helix, involved in the association with the channel domain [ ]. The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22846"
] | [
"CATSPERG_C"
] | [
670
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00067742",
"PUB00100197",
"PUB00152447"
] | [
"21224844",
"19516020",
"34225353",
"22285849"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",
"Structure of a mammalian sperm cation channel complex.",
"Nongenomic actions of aldosterone and progesterone rev... | [
2011,
2009,
2021,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
670
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2
] | 3 | true | Domain | CATSPERG, C-terminal domain | CATSPERG, C-terminal domain | CATSPERG_C | 7 |
IPR053874 | 53,874 | CATSPERG, Ig-like domain | CATSPERG_Ig-like | Domain | 628 | false | false | This entry represents the Ig-like domain of of the gamma subunit (CATSPERG). The CatSper (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 that functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22851"
] | [
"CATSPERG_Ig-like"
] | [
628
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00067742",
"PUB00100197",
"PUB00152447"
] | [
"21224844",
"19516020",
"34225353",
"22285849"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.",
"Structure of a mammalian sperm cation channel complex.",
"Nongenomic actions of aldosterone and progesterone rev... | [
2011,
2009,
2021,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
628
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2
] | 3 | true | Domain | CATSPERG, Ig-like domain | CATSPERG, Ig-like domain | CATSPERG_Ig-like | 4 |
IPR053875 | 53,875 | Cytochrome c-type protein NrfB-like domain | Cytochrom_c_NrfB-like_dom | Domain | 1,800 | false | false | This entry includes Cytochrome c-type protein NrfB and similar proteins, which plays a role in nitrite reduction. These proteins contain several copies of the CXXCH haem-binding motif [ , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22678"
] | [
"Cytochrom_c_NrfB-like"
] | [
1800
] | 1 | [] | [] | [] | 0 | [
"2ozy",
"2p0b",
"6r2q"
] | 3 | [
"PUB00014111",
"PUB00040130",
"PUB00044018",
"PUB00151188"
] | [
"11095707",
"16156654",
"17521287",
"32289252"
] | [
"Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum: thermostability and electron transfer.",
"Structural and biochemical characterization of DHC2, a novel diheme cytochrome c from Geobacter sulfurreducens.",
"The crystal structure of the pe... | [
2000,
2005,
2007,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Anopheles maculatus",
"Bacteria",
"unclassified sequences"
] | [
1,
1789,
10
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Cytochrome c-type protein NrfB-like domain | Cytochrome c-type protein NrfB-like domain | Cytochrom_c_NrfB-like_dom | 7 |
IPR053876 | 53,876 | Phage integrase, central domain | Phage_int_M | Domain | 26,923 | false | false | This is the central domain of phage integrases and similar sequences from tailed bacteriophages and bacterial prophages. This domain is known to mediate DNA binding and binds to the major groove adjacent to the site of DNA cleavage [ ]. It consists of two pairs of antiparallel helices that pack together at nearly a rig... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22022"
] | [
"Phage_int_M"
] | [
26923
] | 1 | [] | [] | [] | 0 | [
"2khv",
"2kj5",
"2kj8",
"2kj9",
"2kkv",
"2kob"
] | 6 | [
"PUB00029750",
"PUB00038703",
"PUB00048570",
"PUB00154165"
] | [
"12887904",
"15973401",
"18540053",
"27223329"
] | [
"A conformational switch controls the DNA cleavage activity of lambda integrase.",
"A structural basis for allosteric control of DNA recombination by lambda integrase.",
"Crystallization and structure determination of the core-binding domain of bacteriophage lambda integrase.",
"Structure of a Holliday juncti... | [
2003,
2005,
2008,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Plasmid pFKY1",
"Viruses",
"unclassified sequences"
] | [
26504,
40,
1,
130,
248
] | 5 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | Phage integrase, central domain | Phage integrase, central domain | Phage_int_M | 7 |
IPR053877 | 53,877 | Anti-sigma-K factor RskA, N-terminal domain | RskA_N | Domain | 1,708 | false | false | This domain is found at the N-terminal of the anti-sigma-K factor from Mycobacterium tuberculosis (RskA) [ , ] and similar proteins mainly found in actinomycetes. RskA (regulator of sigma K) represses the extra-cytoplasmic function (ECF) sigma factor K (sigK) by binding to it and inhibiting its activity [ ]. This leads... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22618"
] | [
"RskA_N"
] | [
1708
] | 1 | [] | [] | [] | 0 | [
"4nqw"
] | 1 | [
"PUB00044881",
"PUB00044882",
"PUB00154216"
] | [
"18203833",
"17064366",
"24699647"
] | [
"Evolution of the mycobacterial SigK regulon.",
"Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis.",
"Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex."
] | [
2008,
2006,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Volvox carteri f. nagariensis",
"freshwater metagenome"
] | [
1704,
1,
3
] | 3 | [] | [] | 0 | true | Domain | Anti-sigma-K factor RskA, N-terminal domain | Anti-sigma-K factor RskA, N-terminal domain | RskA_N | 1 |
IPR053878 | 53,878 | Major fimbrium subunit FimA, C-terminal domain | FimA_C | Domain | 170 | false | false | This entry represents the C-terminal domain of Major fimbrium subunit FimA from Porphyromonas gingivalis and similar sequences from Bacteroidales. It folds into a Ig-like β-sandwich having the characteristic features of the FimA superfamily. FimA is the structural subunit of the fimbriae, which are filamentous appendag... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22492"
] | [
"FimA4_C"
] | [
170
] | 1 | [] | [] | [] | 0 | [
"4q98",
"6jzj",
"6jzk",
"6kmf"
] | 4 | [
"PUB00069819",
"PUB00080711",
"PUB00085075",
"PUB00153946"
] | [
"17081195",
"27062925",
"26001707",
"32284566"
] | [
"Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype.",
"A Distinct Type of Pilus from the Human Microbiome.",
"A Major Fimbrilin Variant of Mfa1 Fimbriae in Porphyromonas gingivalis.",
"Structure of polymerized type V pilin reveals assembly mechanism invol... | [
2007,
2016,
2015,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteroidales"
] | [
170
] | 1 | [] | [] | 0 | true | Domain | Major fimbrium subunit FimA, C-terminal domain | Major fimbrium subunit FimA, C-terminal domain | FimA_C | 1 |
IPR053879 | 53,879 | HYDIN/VesB/CFA65-like, Ig-like domain | HYDIN_VesB_CFA65-like_Ig | Domain | 7,645 | false | false | VesB is a serine protease that is secreted by the type II secretion system (T2S) in Vibrio cholerae ( ). It efficiently cleaves a trypsin substrate, but not chymotrypsin and elastase substrates [ ]. It has been suggested to contribute to intestinal growth or pathogenesis, although is not the only factor required for in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22544"
] | [
"HYDIN_VesB_CFA65-like_Ig"
] | [
7645
] | 1 | [] | [] | [] | 0 | [
"2e6j",
"2qsv",
"2ys4",
"4lk4",
"7n61",
"7n6g",
"7som",
"7sqc",
"9ijj"
] | 9 | [
"PUB00154020"
] | [
"24459146"
] | [
"Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
70,
2574,
14,
4897,
90
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
14,
7,
13
] | 4 | true | Domain | HYDIN/VesB/CFA65-like, Ig-like domain | HYDIN/VesB/CFA65-like, Ig-like domain | HYDIN_VesB_CFA65-like_Ig | 7 |
IPR053880 | 53,880 | GPR180-like, N-terminal domain | GPR180-like_N | Domain | 2,420 | false | false | This entry represents the N-terminal domain of GPR180 and TMEM145. This entry includes GPR180 (also known as intimal thickness-related receptor, ITR) and TMEM145 [ ]. In vivo analyses of this gene revealed that expression of GPR180 protein increased with intimal thickening induced by cuff placement around murine femora... | [] | [] | [] | 0 | [
"PFAM",
"PFAM"
] | [
"PF21870",
"PF21892"
] | [
"GP180_GOLD",
"TMEM145_N"
] | [
968,
1452
] | 2 | [] | [] | [] | 0 | [
"9fow"
] | 1 | [
"PUB00044287",
"PUB00151072",
"PUB00151077"
] | [
"12538434",
"36373655",
"34880217"
] | [
"Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor.",
"Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.",
"GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects ... | [
2003,
2022,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2419,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
6,
5,
9
] | 5 | true | Domain | GPR180-like, N-terminal domain | GPR180-like, N-terminal domain | GPR180-like_N | 2 |
IPR053882 | 53,882 | Nlrc4-like, winged helix domain | Nlrc4-like_WHD | Domain | 698 | false | false | This entry represents the winged helix domain (WHD) of NLR family CARD domain-containing protein 4 from mouse (Nlrc4) and similar sequences from vertebrates. Nlrc4 is a component of the inflammasome activated as part of the innate immune response [ ]. This domain is also found in human Baculoviral IAP repeat-containing... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22524"
] | [
"WHD_Nlrc4"
] | [
698
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803207",
"R-HSA-844623"
] | [
"REACTOME:R-HSA-6803207",
"REACTOME:R-HSA-844623"
] | 2 | [
"3jbl",
"4kxf",
"5aj2",
"5yud",
"6b5b",
"7rav",
"8fml",
"8fvu",
"8fw2",
"8fw9"
] | 10 | [
"PUB00057649",
"PUB00091150",
"PUB00154105",
"PUB00154106",
"PUB00154107",
"PUB00154108"
] | [
"19923725",
"23765277",
"26449474",
"26585513",
"29182158",
"29146805"
] | [
"Structures of BIR domains from human NAIP and cIAP2.",
"Crystal structure of NLRC4 reveals its autoinhibition mechanism.",
"Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.",
"Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation... | [
2009,
2013,
2015,
2015,
2018,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
698
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
24,
9
] | 3 | true | Domain | Nlrc4-like, winged helix domain | Nlrc4-like, winged helix domain | Nlrc4-like_WHD | 3 |
IPR053883 | 53,883 | DUF3097, N-terminal domain | DUF3097_N | Domain | 4,242 | false | false | This entry represents a domain found at the N-terminal of a group of uncharacterised proteins mainly found in Actinomycetes. Members of this group are thought to have a nuclease function [ ]. This domain is predicted to show high structural similarity with a Tudor domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22845"
] | [
"DUF3097_N"
] | [
4242
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152793"
] | [
"36419248"
] | [
"DALI shines a light on remote homologs: One hundred discoveries."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caenorhabditis remanei",
"metagenomes"
] | [
4206,
1,
35
] | 3 | [] | [] | 0 | true | Domain | DUF3097, N-terminal domain | DUF3097, N-terminal domain | DUF3097_N | 2 |
IPR053886 | 53,886 | DUF4026, middle domain | DUF4026_middle | Domain | 383 | false | false | This entry represents a domain found in uncharacterised bacterial proteins. It is usually associated with and that flank this domain from N- and C-terminal ends, respectively. This domain is distantly related to SUFU-like domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22789"
] | [
"DUF4026_C"
] | [
383
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
383
] | 1 | [] | [] | 0 | true | Domain | DUF4026, middle domain | DUF4026, middle domain | DUF4026_middle | 2 |
IPR053887 | 53,887 | Major capsid protein V20, C-terminal domain | MCP_V20_C | Domain | 50 | false | false | This is the C-terminal domain of major capsid protein V20 from Sputnik virophage. This domain folds into a β-sandwich with a jelly-roll topology [ ]. V20 is a major capsid protein from Sputnik virophage. This is a dsDNA virus, referred to as a virophage, that is co-assembled with Mimivirus in the host amoeba. The capsi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22031"
] | [
"MCP_V20_C"
] | [
50
] | 1 | [] | [] | [] | 0 | [
"3j26",
"6g43",
"6g44",
"6g45"
] | 4 | [
"PUB00151820"
] | [
"23091035"
] | [
"Structure of Sputnik, a virophage, at 3.5-A resolution."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteroides mediterraneensis",
"Cafeteria roenbergensis",
"Viruses",
"marine sediment metagenome"
] | [
1,
25,
21,
3
] | 4 | [] | [] | 0 | true | Domain | Major capsid protein V20, C-terminal domain | Major capsid protein V20, C-terminal domain | MCP_V20_C | 5 |
IPR053888 | 53,888 | MRM3-like, substrate binding domain | MRM3-like_sub_bind | Domain | 18,654 | false | false | MRM3 catalyses the formation of 2'-O-methylguanosine at position 1370 Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA [ , , , ]. This entry represents the substrate binding domain of MRM3 from animals and related se... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22435"
] | [
"MRM3-like_sub_bind"
] | [
18654
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 147 | [
"1ipa",
"2i6d",
"4x3l",
"4x3m",
"5kzk",
"5l0z",
"7oi6",
"7qiu",
"9h1k",
"9hcc",
"9hcd",
"9hce",
"9muj",
"9muk"
] | 14 | [
"PUB00016836",
"PUB00032343",
"PUB00101942",
"PUB00102369",
"PUB00154081",
"PUB00154377"
] | [
"12077432",
"15581897",
"35710145",
"25009282",
"34315873",
"35177605"
] | [
"An enzyme with a deep trefoil knot for the active-site architecture.",
"Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.",
"The <i>Bacillus subtilis</i> open reading frame <i>ysgA</i> encodes the SPOUT methyltransferase RlmP forming 2'-<... | [
2002,
2005,
2022,
2014,
2021,
2022
] | 6 | [
"IPR013123"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
17064,
1280,
1,
309
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
1,
2
] | 5 | true | Domain | MRM3-like, substrate binding domain | MRM3-like, substrate binding domain | MRM3-like_sub_bind | 9 |
IPR053889 | 53,889 | Major capsid protein V20, N-terminal domain | Sputnik_MCP_N | Domain | 20 | false | false | This entry represents the N-terminal domain of the major capsid protein V20 from Sputnik virophage, which adopts a jelly roll fold [ ]. Sputnik is a dsDNA virus, referred to as a virophage, that is co-assembled with Mimivirus in the host amoeba. The capsid is organized into a T = 27 lattice in which there are 260 trime... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21915"
] | [
"Sputnik_MCP_1st"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"3j26"
] | 1 | [
"PUB00151820"
] | [
"23091035"
] | [
"Structure of Sputnik, a virophage, at 3.5-A resolution."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses",
"marine sediment metagenome"
] | [
17,
3
] | 2 | [] | [] | 0 | true | Domain | Major capsid protein V20, N-terminal domain | Major capsid protein V20, N-terminal domain | Sputnik_MCP_N | 9 |
IPR053890 | 53,890 | Hen1-like, N-terminal domain | Hen1-like_N | Domain | 195 | false | false | This entry represents the N-terminal domain of Hen1 from Capnocytophaga gingivalis and related proteins. This protein is a component of the bacterial RNA repair complex composed of three proteins: Pnkp1, Rnl and Hen1. This complex neutralises the damage inflicted by ribotoxins which is essential for cell survival. The ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22032"
] | [
"Hen1_N"
] | [
195
] | 1 | [] | [] | [] | 0 | [
"4xrp",
"4xru"
] | 2 | [
"PUB00154001"
] | [
"25882814"
] | [
"Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Klosneuvirinae"
] | [
189,
6
] | 2 | [] | [] | 0 | true | Domain | Hen1-like, N-terminal domain | Hen1-like, N-terminal domain | Hen1-like_N | 8 |
IPR053891 | 53,891 | Shisa, N-terminal domain | Shisa_N | Domain | 8,955 | false | false | Shisa is a transmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface. Vertebrate homologues play roles in development... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13908"
] | [
"Shisa_N"
] | [
8955
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275"
] | [
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275"
] | 6 | [
"5m0w"
] | 1 | [
"PUB00062002",
"PUB00062003",
"PUB00062005",
"PUB00062018",
"PUB00154231"
] | [
"15680328",
"18033675",
"22120523",
"16773659",
"28325875"
] | [
"Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.",
"Expression of Shisa2, a modulator of both Wnt and Fgf signaling, in the chick embryo.",
"Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transme... | [
2005,
2008,
2012,
2006,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
8955
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
38,
16,
19,
28
] | 4 | true | Domain | Shisa, N-terminal domain | Shisa, N-terminal domain | Shisa_N | 7 |
IPR053892 | 53,892 | MoaF-like | MoaF-like | Domain | 973 | false | false | This domain consists mainly of uncharacterised bacterial proteins that are related to MoaF and adopt very similar β-barrel structure. In some instances, this domain appears twice. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22036"
] | [
"MoaF_like"
] | [
973
] | 1 | [] | [] | [] | 0 | [
"5hal"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ascoviridae",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
5,
957,
7,
4
] | 4 | [] | [] | 0 | true | Domain | MoaF-like | MoaF-like | MoaF-like | 8 |
IPR053893 | 53,893 | Polycomb protein EED-like, insertion domain | PRC2_EED-like_ins | Domain | 33 | false | false | EED ( ) is one of the core subunits of Polycomb Repressive Complex 2 (PRC2) that is involved in histone methylation. EED consists of two domains: a seven-bladed β-propeller and a small α/β domain that is inserted into the sixth blade [ ]. EED specifically binds to histone tails carrying trimethyl-lysine residues associ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22038"
] | [
"PRC2_EED_ins"
] | [
33
] | 1 | [] | [] | [] | 0 | [
"5bjs",
"5kjh",
"5kji",
"5kkl",
"5m5g",
"5tqr",
"5vk3",
"5wf7",
"5wfc",
"5wfd"
] | 10 | [
"PUB00054794",
"PUB00107029"
] | [
"19767730",
"28607149"
] | [
"Role of the polycomb protein EED in the propagation of repressive histone marks.",
"Polycomb repressive complex 2 in an autoinhibited state."
] | [
2009,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
33
] | 1 | [] | [] | 0 | true | Domain | Polycomb protein EED-like, insertion domain | Polycomb protein EED-like, insertion domain | PRC2_EED-like_ins | 3 |
IPR053894 | 53,894 | Out at first protein, BRICHOS-like domain | OAF_N | Domain | 1,333 | false | false | This entry represents the BRICHOS-like domain found at the N-terminal of Out at first protein (OAF) protein family [ ]. OAF is vital for proper neuronal development and hatching [ ]. The gene that encodes this protein, has a promoter which may help mediate regulation of neighbouring genes [ ]. An alternative name for t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14941"
] | [
"OAF_N"
] | [
1333
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060399",
"PUB00060400",
"PUB00110938",
"PUB00154132"
] | [
"7768442",
"8675012",
"11390611",
"36699367"
] | [
"Regulatory autonomy and molecular characterization of the Drosophila out at first gene.",
"Promoter specificity mediates the independent regulation of neighboring genes.",
"Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral respon... | [
1995,
1996,
2001,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1333
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
2,
1,
2
] | 5 | true | Domain | Out at first protein, BRICHOS-like domain | Out at first protein, BRICHOS-like domain | OAF_N | 9 |
IPR053895 | 53,895 | Domain of unknown function DUF7011 | DUF7011 | Domain | 530 | false | false | This domain of unknown function is found in a group of proteins predominantly from proteobacteria. It has a LxHDGK/RRL motif and a highly conserved W residue. It is usually found C-terminal to and N-terminal to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22791"
] | [
"DUF7011"
] | [
530
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gibberella intermedia",
"Pseudomonadota",
"metagenomes"
] | [
1,
520,
9
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7011 | Domain of unknown function DUF7011 | DUF7011 | 9 |
IPR053896 | 53,896 | Butyrophilin subfamily 3 member A2-like, Ig-C domain | BTN3A2-like_Ig-C | Domain | 14,338 | false | false | This domain is found in proteins from B7 family, including Butyrophilin subfamily 3 member A1/A2 (BTN3A1/A2) and similar proteins [ , ]. BTN3A2 is a protein that plays a role in T-cell responses in the adaptive immune response [ ]. BTN3A2 shows two extracellular domains: an N-terminal Ig-V like domain ( ) and a C-termi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22705"
] | [
"C2-set_3"
] | [
14338
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-373753",
"R-HSA-389948",
"R-HSA-8851680",
"R-HSA-9927354",
"R-MMU-389948",
"R-MMU-8851680",
"R-RNO-8851680"
] | [
"REACTOME:R-CEL-373753",
"REACTOME:R-HSA-389948",
"REACTOME:R-HSA-8851680",
"REACTOME:R-HSA-9927354",
"REACTOME:R-MMU-389948",
"REACTOME:R-MMU-8851680",
"REACTOME:R-RNO-8851680"
] | 7 | [
"3bp5",
"3bp6",
"3rnq",
"4f80",
"4f8q",
"4f8t",
"4f9l",
"4f9p",
"4hh8",
"4i0k",
"4ofp",
"4ofy",
"6x4g",
"6x4t",
"6xlq",
"8dfw",
"8dfx",
"8dfy",
"8vc7",
"8za9",
"8zab",
"8zyr",
"9dpe",
"9iik",
"9j5j",
"9j5m",
"9jq6",
"9jqp",
"9jqq",
"9jqr"
] | 30 | [
"PUB00153839",
"PUB00154378",
"PUB00154379"
] | [
"22846996",
"10354554",
"15961727"
] | [
"The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.",
"Structure and evolution of the extended B7 family.",
"Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells."
] | [
2012,
1999,
2005
] | 3 | [
"IPR007110"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
14338
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
35,
67,
50,
80
] | 5 | true | Domain | Butyrophilin subfamily 3 member A2-like, Ig-C domain | Butyrophilin subfamily 3 member A2-like, Ig-C domain | BTN3A2-like_Ig-C | 5 |
IPR053897 | 53,897 | Out at first, C-terminal | Oaf_C | Domain | 1,250 | false | false | This entry represents the putative C-terminal cysteine-rich mature peptide found in Out at first (Oaf) animal proteins [ ]. Oaf is vital in for proper neuronal development and hatchin [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22873"
] | [
"OAF_C"
] | [
1250
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060399",
"PUB00060400",
"PUB00154132"
] | [
"7768442",
"8675012",
"36699367"
] | [
"Regulatory autonomy and molecular characterization of the Drosophila out at first gene.",
"Promoter specificity mediates the independent regulation of neighboring genes.",
"OAF: a new member of the BRICHOS family."
] | [
1995,
1996,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1250
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
2,
2,
2
] | 5 | true | Domain | Out at first, C-terminal | Out at first, C-terminal | Oaf_C | 8 |
IPR053899 | 53,899 | C5orf34-like, second domain | C5orf34-like_2nd | Domain | 705 | false | false | This entry represents a domain located C-terminal to in a family of eukaryotic proteins, including the human uncharacterised protein C5orf34, which has been reported to be correlated with an unfavorable prognosis of patients from a variety of human malignancies [ , ]. This domain is predicted to show an α/β structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22833"
] | [
"C5orf34_2nd"
] | [
705
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154383",
"PUB00154384"
] | [
"30771479",
"38078888"
] | [
"Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis.",
"Integration of genomics and transcriptomics highlights the crucial role of chromosome 5 open reading frame 34 in various human malignancies."
] | [
2019,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
705
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
4,
2,
9
] | 4 | true | Domain | C5orf34-like, second domain | C5orf34-like, second domain | C5orf34-like_2nd | 5 |
IPR053900 | 53,900 | C5orf34-like domain | C5orf34-like_dom | Domain | 712 | false | false | This entry represents a domain found in a family of eukaryotic proteins, including the human uncharacterised protein C5orf34, which has been reported to be correlated with an unfavorable prognosis of patients from a variety of human malignancies [ , ]. This domain appears C-terminal to and and N-terminal to . This doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22834"
] | [
"Polo_box_4"
] | [
712
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091236",
"PUB00154383",
"PUB00154384"
] | [
"24980795",
"30771479",
"38078888"
] | [
"Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.",
"Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis.",
"Integration of genomics and transcriptomics highlights the crucial role of chro... | [
2014,
2019,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
712
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
1,
1,
9
] | 4 | true | Domain | C5orf34-like domain | C5orf34-like domain | C5orf34-like_dom | 7 |
IPR053902 | 53,902 | Interleukin 33, C-terminal | IL33_C | Domain | 364 | false | false | This entry represents a β-trefoil-related domain found at the C-terminal of interleukin-33 (IL33) from vertebrates. This protein binds to and signals through IL1RL1/ST2 and its stimulation leads to the recruitment of MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15095"
] | [
"IL33_bt"
] | [
364
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-1257604",
"R-CFA-5689880",
"R-CFA-6811558",
"R-HSA-1257604",
"R-HSA-5689880",
"R-HSA-6811558",
"R-HSA-9014843",
"R-MMU-1257604",
"R-MMU-5689880",
"R-MMU-6811558",
"R-MMU-9014843",
"R-RNO-1257604",
"R-RNO-5689880",
"R-RNO-6811558",
"R-RNO-9014843"
] | [
"REACTOME:R-CFA-1257604",
"REACTOME:R-CFA-5689880",
"REACTOME:R-CFA-6811558",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-9014843",
"REACTOME:R-MMU-1257604",
"REACTOME:R-MMU-5689880",
"REACTOME:R-MMU-6811558",
"REACTOME:R-MMU-9014843",
"REACTOM... | 15 | [
"2kll",
"4kc3",
"5vi4",
"8q5r"
] | 4 | [
"PUB00070029",
"PUB00070030"
] | [
"17185418",
"22215666"
] | [
"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.",
"Interleukin 33 as a mechanically responsive cytokine secreted by living cells."
] | [
2007,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Theria"
] | [
364
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
5
] | 3 | true | Domain | Interleukin 33, C-terminal | Interleukin 33, C-terminal | IL33_C | 3 |
IPR053903 | 53,903 | CATSPERB, head domain | CATSPERB_head | Domain | 337 | false | false | CATSPERB (Cation channel sperm-associated protein subunit beta) is an auxiliary subunit of the CatSper complex which is involved in sperm cell hyperactivation, a process needed for sperm motility which is essential late in the preparation of sperm for fertilisation. This is a multi-domain protein which consists of an N... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22830"
] | [
"CATSPERB_head"
] | [
337
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00100197"
] | [
"34225353"
] | [
"Structure of a mammalian sperm cation channel complex."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
337
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1
] | 3 | true | Domain | CATSPERB, head domain | CATSPERB, head domain | CATSPERB_head | 9 |
IPR053904 | 53,904 | CATSPERB, Ig-like domain | CATSPERB_Ig-like | Domain | 306 | false | false | CATSPERB (Cation channel sperm-associated protein subunit beta) is an auxiliary subunit of the CatSper complex which is involved in sperm cell hyperactivation, a process needed for sperm motility which is essential late in the preparation of sperm for fertilisation. This is a multi-domain protein which consists of an N... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22831"
] | [
"CATSPERB_Ig-like"
] | [
306
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642"
] | 2 | [
"7eeb"
] | 1 | [
"PUB00100197"
] | [
"34225353"
] | [
"Structure of a mammalian sperm cation channel complex."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
306
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1
] | 3 | true | Domain | CATSPERB, Ig-like domain | CATSPERB, Ig-like domain | CATSPERB_Ig-like | 8 |
IPR053907 | 53,907 | Domain of unknown function DUF6935 | DUF6935 | Domain | 190 | false | false | This is a domain found in uncharacterised bacterial proteins either as standalone or in combination with other domains. It is remotely related to soluble lipid-binding protein MlaC and it is predicted to adopt a similar structure with a typical NTF2-like topology ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22043"
] | [
"DUF6935"
] | [
190
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Anaeromyces robustus",
"Bacteria",
"metagenomes"
] | [
1,
184,
5
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF6935 | Domain of unknown function DUF6935 | DUF6935 | 4 |
IPR053908 | 53,908 | Chloramphenicol halogenase CmlS, C-terminal domain | CmlS_C | Domain | 45 | false | false | Chloramphenicol halogenase CmlS ( ) belongs to the large and diverse superfamily of flavin-dependent halogenases. CmlS is one of the few enzymes known to halogenate an alkyl group. This entry represents the C-terminal domain of CmlS that resembles an arch-like structure above a central α-helix. This domain creates a T-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22045"
] | [
"CmlS_C"
] | [
45
] | 1 | [] | [] | [] | 0 | [
"3i3l"
] | 1 | [
"PUB00153872"
] | [
"20080101"
] | [
"Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
45
] | 1 | [] | [] | 0 | true | Domain | Chloramphenicol halogenase CmlS, C-terminal domain | Chloramphenicol halogenase CmlS, C-terminal domain | CmlS_C | 4 |
IPR053909 | 53,909 | Enoyl-acyl carrier protein reductase FabMG | FabMG | Family | 312 | false | false | This entry, previously known as DUF6936, represents FabMG enoyl-acyl carrier protein reductase (ENR) and related proteins. This enzyme is a FabI-type ENR that employs NADH as a coenzyme and mediates resistance to triclosan. FabMG ( , ) adopts an α/β structure, with a central parallel β-sheet elaborated with α-helices o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22046"
] | [
"FabMG"
] | [
312
] | 1 | [] | [] | [] | 0 | [
"6ki9",
"6kia"
] | 2 | [
"PUB00154385"
] | [
"32112503"
] | [
"A triclosan-resistance protein from the soil metagenome is a novel enoyl-acyl carrier protein reductase: Structure-guided functional analysis."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
308,
4
] | 2 | [] | [] | 0 | true | Family | Enoyl-acyl carrier protein reductase FabMG | Enoyl-acyl carrier protein reductase FabMG | FabMG | 4 |
IPR053910 | 53,910 | RsmI, HTH domain | RsmI_HTH | Domain | 11,008 | false | false | This entry represents a small α-helical domain at the C terminus of RsmI mainly from proteobacteria and actinomycetes, that folds into a typical three helical DNA/RNA binding bundle containing an HTH motif. This domain is found in Ribosomal RNA small subunit methyltransferase I (RsmI) and related proteins. RsmI is an S... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23016"
] | [
"RsmI_C"
] | [
11008
] | 1 | [
"EC"
] | [
"2.1.1.198"
] | [
"EC:2.1.1.198"
] | 1 | [
"9pzg"
] | 1 | [
"PUB00095802"
] | [
"27711192"
] | [
"Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halorubrum tibetense",
"unclassified sequences"
] | [
10713,
144,
1,
150
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
1,
3,
1
] | 3 | true | Domain | RsmI, HTH domain | RsmI, HTH domain | RsmI_HTH | 5 |
IPR053911 | 53,911 | PGAP2IP, second transmembrane domain | PGAP2IP_TM_2nd | Domain | 2,579 | false | false | This domain is found in the human PGAP2-interacting protein (PGAP2IP) and its homologues in yeast CWH43. PGAP2IP is composed of three domains. Two of these domains are predicted to adopt very similar structure consisting of six transmembrane helices, which suggests a possible duplication event in these proteins. Its ye... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23021"
] | [
"6TM_2nd_PGAP2IP"
] | [
2579
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00063839"
] | [
"17761529"
] | [
"Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2579
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
5,
1,
1,
5,
1,
1
] | 6 | true | Domain | PGAP2IP, second transmembrane domain | PGAP2IP, second transmembrane domain | PGAP2IP_TM_2nd | 2 |
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