LiteFold/InterPro · Datasets at Hugging Face

IPR005522

5,522

Inositol polyphosphate kinase

IPK

Family

16,054

false

Inositol phosphates (IPs) act as signalling messengers to regulate various cellular processes such as growth. This entry includes a group of inositol polyphosphate kinase, including inositol polyphosphate multikinase Arg82 and Inositol hexakisphosphate/inositol heptakisphosphate kinase Kcs1 from budding yeast. They pla...

[ "GO:0016301", "GO:0032958" ]

[ "kinase activity", "inositol phosphate biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03770", "PTHR12400" ]

[ "IPK", "" ]

[ 15695, 15560 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "GenProp1229", "GenProp1249", "GenProp1460", "GenProp1509", "GenProp1574", "GenProp1692", "R-CEL-1855204", "R-HSA-1855167", "R-HSA-1855191", "R-HSA-1855204", "R-HSA-909733", "R-MMU-1855167", "R-MMU-1855191", "R-MMU-1855204", "R-RNO-1855167", "R-RNO-1855191", "R-RNO-1855204...

[ "EC:2.7.1", "GP:GenProp1229", "GP:GenProp1249", "GP:GenProp1460", "GP:GenProp1509", "GP:GenProp1574", "GP:GenProp1692", "REACTOME:R-CEL-1855204", "REACTOME:R-HSA-1855167", "REACTOME:R-HSA-1855191", "REACTOME:R-HSA-1855204", "REACTOME:R-HSA-909733", "REACTOME:R-MMU-1855167", "REACTOME:R-MMU...

22

[ "1tzd", "1w2c", "1w2d", "1w2f", "2a98", "2aqx", "2iew", "2if8", "4frf", "4o4b", "4o4c", "4o4d", "4o4e", "4o4f", "5w2g", "5w2h", "5w2i", "6e7f", "6m88", "6m89", "6m8a", "6m8b", "6m8c", "6m8d", "6m8e", "8omi", "8pp8", "8pp9", "8ppa", "8ppb", "8ppc", "8ppd"...

65

[ "PUB00087183", "PUB00087184", "PUB00087185", "PUB00087186", "PUB00087187", "PUB00095238" ]

[ "12828642", "12223481", "18498254", "11502751", "23050966", "30420721" ]

[ "Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast.", "The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.", "Ins(1,4,5)P3 3-kinase-A ov...

[ 2003, 2002, 2008, 2001, 2012, 2018 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Klosneuvirinae", "Methanosarcina", "viral metagenome" ]

[ 37, 16005, 4, 5, 3 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 5, 25, 18, 31, 22, 3, 1, 28, 2, 2, 17 ]

12

true

Family

Inositol polyphosphate kinase

IPK

1

IPR005523

5,523

Domain of unknown function DUF317, SPDY

DUF317_SPDY

Domain

1,784

false

This domain is currently found in streptomyces bacteria, in a set of bacterial proteins with no known function. Most proteins contain two copies of this domain [ ].

[]

0

[ "PFAM" ]

[ "PF03771" ]

[ "SPDY" ]

[ 1784 ]

1

[]

0

[]

0

[ "PUB00016669" ]

[ "12625841" ]

[ "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria" ]

[ 1784 ]

1

[]

0

true

Domain

Domain of unknown function DUF317, SPDY

DUF317_SPDY

5

IPR005524

5,524

Predicted permease DUF318

DUF318

Family

17,196

false

This family of integral membrane proteins are predicted to be permeases of unknown specificity.

[]

0

[ "PFAM" ]

[ "PF03773" ]

[ "ArsP_1" ]

[ 17196 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Plasmid pMCBF1", "unclassified sequences" ]

[ 837, 15921, 45, 1, 392 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Predicted permease DUF318

DUF318

3

IPR005526

5,526

Septum formation inhibitor MinC, C-terminal

Septum_form_inhib_MinC_C

Domain

11,275

false

In Escherichia coli, three Min proteins (MinC, MinD and MinE) negatively regulate FtsZ assembly at the cell poles in order to ensure the Z-ring only assembles at cell midpoint. MinC inhibits formation of the Z-ring by preventing FtsZ assembly. MinD binds to MinC near the cell poles, sequestering MinC away from the cell...

[ "GO:0000902" ]

[ "cell morphogenesis" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03775" ]

[ "MinC_C" ]

[ 11275 ]

1

[]

0

[ "1hf2", "4v02", "5xdm", "6riq" ]

4

[ "PUB00008426", "PUB00042573" ]

[ "10869074", "17085577" ]

[ "Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ.", "The C-terminal domain of MinC inhibits assembly of the Z ring in Escherichia coli." ]

[ 2000, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11035, 165, 75 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Septum formation inhibitor MinC, C-terminal

Septum_form_inhib_MinC_C

8

IPR005527

5,527

Cell division topological specificity factor MinE

MinE

Family

9,109

false

Cytokinesis needs to be regulated spatially in order to ensure that it occurs between the daughter genomes. In prokaryotes such as Escherichia coli, cytokinesis is initiated by FtsZ, a tubulin-like protein that assembles into a ring structure at the cell centre called the Z ring. A fundamental problem in prokaryotic ce...

[ "GO:0032955", "GO:0051301" ]

[ "regulation of division septum assembly", "cell division" ]

[ "biological_process", "biological_process" ]

2

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00262", "PF03776", "TIGR01215" ]

[ "MinE", "MinE", "minE" ]

[ 7842, 9109, 8045 ]

3

[ "GP" ]

[ "GenProp0165" ]

[ "GP:GenProp0165" ]

1

[ "1ev0", "2kxo", "3ku7", "3mcd", "3r9j", "6u6p", "6u6q", "6u6r", "6u6s" ]

9

[ "PUB00007870", "PUB00019863", "PUB00069750" ]

[ "11378404", "2645057", "11743109" ]

[ "Bacterial cell division: a moving MinE sweeper boggles the MinD.", "A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli.", "A chloroplast protein homologous to the eubacterial topological specificity factor minE ...

[ 2001, 1989, 2001 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8148, 889, 72 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 2, 4 ]

4

true

Family

Cell division topological specificity factor MinE

MinE

9

IPR005528

5,528

Chaplin domain

ChpA-H

Domain

7,194

false

Streptomycetes differentiate by forming specialized spore-bearing aerial hyphae that grow into the air. In order to break surface tension streptomycetes have to coat their aerial hyphae in an extremely hydrophobic sheath that is absent from the vegetative hyphae growing in the aqueous phase. The hydrophobic sheath, whi...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF03777", "PS51884" ]

[ "ChpA-C", "CHAPLIN" ]

[ 7048, 7002 ]

2

[]

0

[]

0

[ "PUB00092203", "PUB00092204", "PUB00094796" ]

[ "12832397", "12832396", "22582857" ]

[ "The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.", "A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.", "Expression of the chaplin and rod...

[ 2003, 2003, 2012 ]

3

[]

0

null

[ "Bacteria", "Fungi" ]

[ 7148, 46 ]

2

[]

0

true

Domain

Chaplin domain

ChpA-H

5

IPR005529

5,529

Protein of unknown function DUF321

DUF321

Repeat

120

false

This entry represents a group of tandem repeats, found in Arabidopsis species, whose sequence is distantly related to the FARP (FMRFamide) group of neuropeptides ( ). The function of these repeats is not known, being mostly found in uncharacterised proetins, but they are also present in the nuclear migration protein NU...

[]

0

[ "PFAM" ]

[ "PF03778" ]

[ "DUF321" ]

[ 120 ]

1

[]

0

[]

0

[ "PUB00043273" ]

[ "11266443" ]

[ "Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast." ]

[ 2001 ]

1

[]

0

null

[ "Brassicaceae" ]

[ 120 ]

1

[ "Arabidopsis thaliana" ]

[ 25 ]

1

true

Repeat

Protein of unknown function DUF321

DUF321

1

IPR005531

5,531

Alkaline shock protein Asp23

Asp23

Family

18,241

false

Asp23 was identified as an alkaline shock protein expressed in a sigmaB-dependent manner in Staphylococcus aureus ( ) [ ]. Following an alkaline shock, Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. a...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03780", "PTHR34297" ]

[ "Asp23", "" ]

[ 18239, 15881 ]

2

[]

0

[]

0

[ "PUB00008427", "PUB00075359" ]

[ "7864904", "25074408" ]

[ "Isolation and the gene cloning of an alkaline shock protein in methicillin resistant Staphylococcus aureus.", "Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus." ]

[ 1995, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 18085, 10, 146 ]

3

[]

0

true

Family

Alkaline shock protein Asp23

Asp23

5

IPR005532

5,532

Sulfatase-modifying factor enzyme-like domain

SUMF_dom

Domain

49,919

false

This domain is found in sulfatase-modifying factors (SUMFs) [ ] and Chlamydia serine/threonine-protein kinase pkn1 [ ]. It is also found in iron(II)-dependent oxidoreductase from Mycobacterium [ , ].

[]

0

[ "PFAM" ]

[ "PF03781" ]

[ "FGE-sulfatase" ]

[ 49919 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1663150", "R-BTA-9840310", "R-HSA-1663150", "R-HSA-9840310", "R-MMU-1663150", "R-MMU-9840310" ]

[ "REACTOME:R-BTA-1663150", "REACTOME:R-BTA-9840310", "REACTOME:R-HSA-1663150", "REACTOME:R-HSA-9840310", "REACTOME:R-MMU-1663150", "REACTOME:R-MMU-9840310" ]

6

[ "1y1e", "1y1f", "1y1g", "1y1h", "1y1i", "1y1j", "1y4j", "1z70", "2aft", "2afy", "2aii", "2aij", "2aik", "2hi8", "2hib", "2q17", "2y3c", "4x8b", "4x8d", "4x8e", "5aoh", "5hha", "5nxl", "5nyy", "5ssx", "5ssy", "5ssz", "5vf4", "6muj", "6o6l", "6o6m", "6qki"...

65

[ "PUB00019471", "PUB00035615", "PUB00035616", "PUB00035617", "PUB00035618", "PUB00054265", "PUB00060032", "PUB00066766" ]

[ "14563551", "16041070", "17206939", "16124866", "16174644", "14500499", "20420449", "15064399" ]

[ "The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes.", "De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data.", "SUMF1 enhances sulfatase activities in vivo in five sulfa...

[ 2003, 2005, 2007, 2005, 2005, 2003, 2010, 2004 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 263, 42357, 6351, 31, 917 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 3, 26, 9, 1, 7, 1 ]

7

true

Domain

Sulfatase-modifying factor enzyme-like domain

SUMF_dom

9

IPR005533

5,533

AMOP domain

AMOP_dom

Domain

6,522

false

This entry represents the AMOP domain found in ISM1/2, Mucin-4, Susd2 and related proteins. The AMOP domain (for adhesion-associated domain in MUC4 and other proteins) is a ~100-residue-long extracellular domain that contains eight invariant cysteine residues that are predicted to be involved in disulphide bonds. The A...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03782", "PS50856", "SM00723" ]

[ "AMOP", "AMOP", "AMOP" ]

[ 5026, 6472, 5729 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50856", "R-HSA-5083625", "R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-MMU-913709", "R-MMU-977068" ]

[ "PROSITEDOC:PDOC50856", "REACTOME:R-HSA-5083625", "REACTOME:R-HSA-5083632", "REACTOME:R-HSA-5083636", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-977068", "REACTOME:R-MMU-913709", "REACTOME:R-MMU-977068" ]

9

[ "9c6t" ]

1

[ "PUB00014202", "PUB00088055", "PUB00092956", "PUB00160755" ]

[ "11893501", "25351403", "19874420", "23131994" ]

[ "AMOP, a protein module alternatively spliced in cancer cells.", "CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest.", "Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.", "Multiple functions of sushi domain containing...

[ 2002, 2014, 2011, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrosopumilus piranensis" ]

[ 13, 6508, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 8, 2, 30, 8, 13 ]

6

true

Domain

AMOP domain

AMOP_dom

3

IPR005534

5,534

Curli production assembly/transport component CsgG

Curli_assmbl/transp-comp_CsgG

Family

7,061

false

CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB [ ]. May be involved in the biogenesis of curli organelles.

[ "GO:0030288" ]

[ "outer membrane-bounded periplasmic space" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03783" ]

[ "CsgG" ]

[ 7061 ]

1

[]

0

[ "3x2r", "4q79", "4uv2", "4uv3", "6l7a", "6l7c", "6lqh", "6lqj", "6si7", "7brm" ]

10

[ "PUB00008428" ]

[ "9383186" ]

[ "Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin-binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG." ]

[ 1997 ]

1

[]

[ "IPR049861" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6824, 14, 18, 205 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Curli production assembly/transport component CsgG

Curli_assmbl/transp-comp_CsgG

6

IPR005535

5,535

Cyclotide

Family

512

false

Cyclotides (cyclo peptides) are plant peptides of ~30 amino acids with a head to-tail cyclic backbone and six cysteine residues involved in three disulphide bonds. The cyclotides are extremely resistant to proteolysis and are remarkably stable. Cyclotides display a diverse range of biological activities, including uter...

[ "GO:0006952" ]

[ "defense response" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PROFILE" ]

[ "PF03784", "PIRSF037891", "PS51052" ]

[ "Cyclotide", "Cycloviolacin", "CYCLOTIDE" ]

[ 506, 154, 463 ]

3

[ "PROSITEDOC" ]

[ "PDOC51052" ]

[ "PROSITEDOC:PDOC51052" ]

1

[ "1bh4", "1df6", "1jjz", "1k48", "1kal", "1n1u", "1nb1", "1nbj", "1orx", "1pt4", "1r1f", "1vb8", "1yp8", "1za8", "1znu", "2b38", "2eri", "2f2i", "2f2j", "2fqa", "2gj0", "2jue", "2jwm", "2k7g", "2kcg", "2kch", "2khb", "2knm", "2knn", "2kuk", "2kux", "2lam"...

55

[ "PUB00008429", "PUB00016616", "PUB00016663", "PUB00016667", "PUB00080270", "PUB00085654" ]

[ "10600388", "12946412", "12482868", "12482862", "21596752", "22467870" ]

[ "Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.", "Primary and 3-D modelled structures of two cyclotides from Viola odorata.", "Twists, knots, and rings in proteins. Structural definition of the cyclotide framework.", "Disulfide folding ...

[ 1999, 2003, 2003, 2003, 2011, 2012 ]

6

[]

0

null

[ "Mesangiospermae" ]

[ 512 ]

1

[ "Zea mays" ]

[ 8 ]

1

true

Family

Cyclotide

9

IPR005536

5,536

Peptidase C25, Ig-like domain

Peptidase_C25_Ig-like_domain

Domain

86

false

This domain is found in almost all members of MEROPS peptidase family C25, (clan CD). Peptidase family C25 is a protein family found in the bacteria Porphyromonas gingivalis (Bacteroides gingivalis) a Gram-negative anaerobic bacterial species strongly associated with adult periodontitis. One of its distinguishing chara...

[ "GO:0008233", "GO:0006508" ]

[ "peptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03785" ]

[ "Peptidase_C25_C" ]

[ 86 ]

1

[ "EC" ]

[ "3.4.22" ]

[ "EC:3.4.22" ]

1

[ "1cvr", "4ief", "4rbm", "4tkx", "5ag8", "5ag9", "6i9a" ]

7

[ "PUB00006278", "PUB00006360", "PUB00006414" ]

[ "1322368", "8926061", "9632563" ]

[ "Cloning, expression, and sequencing of a protease gene (tpr) from Porphyromonas gingivalis W83 in Escherichia coli.", "The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats.", "IS195, an insertion sequence-like element associated with protease genes in ...

[ 1992, 1996, 1998 ]

3

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 80, 6 ]

2

[]

0

true

Domain

Peptidase C25, Ig-like domain

Peptidase_C25_Ig-like_domain

1

IPR005537

5,537

CRISPR type III-associated protein

RAMP_III_fam

Domain

8,269

false

This entry represents a group of CRISPR-associated proteins belonging to the type III RAMP (Repair Associated Mysterious Proteins) family [ ]. Members including in this family are Csm3, Csm5, Cmr6, Cmr4 and Cmr1. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements...

[]

0

[ "PFAM" ]

[ "PF03787" ]

[ "RAMPs" ]

[ 8269 ]

1

[]

0

[ "3x1l", "4l6u", "4n0l", "4qts", "4rdp", "4w8v", "4w8w", "4w8x", "4w8z", "4wnz", "5yjd", "6ae2", "6ifk", "6ifl", "6ifn", "6ifr", "6ifu", "6ify", "6ifz", "6ig0", "6iqw", "6ldn", "6mur", "6mus", "6mut", "6muu", "6nbt", "6nud", "6nue", "6o7e", "6o7h", "6o7i"...

127

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890", "PUB00074281" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147", "21756346" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014, 2011 ]

6

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 1064, 7104, 101 ]

3

[]

0

true

Domain

CRISPR type III-associated protein

RAMP_III_fam

9

IPR005538

5,538

LrgA/CidA family

LrgA/CidA

Family

13,217

false

This family consists of CidA and LrgA, which are bacterial holin-/antiholin-like proteins that function to control cell death and lysis during biofilm development [ , ]. The cidAB operon encodes the holin-like counterpart of the lrgAB operon and acts in a manner opposite from that of lrgAB by increasing extracellular m...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03788", "PTHR33931" ]

[ "LrgA", "" ]

[ 13217, 13083 ]

2

[]

0

[]

0

[ "PUB00055101", "PUB00067860", "PUB00067861" ]

[ "12670989", "21421752", "17452642" ]

[ "The Staphylococcus aureus cidAB operon: evaluation of its role in regulation of murein hydrolase activity and penicillin tolerance.", "Staphylococcus aureus CidA and LrgA proteins exhibit holin-like properties.", "The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphyl...

[ 2003, 2011, 2007 ]

3

[]

[ "IPR022957", "IPR023736", "IPR023760" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 79, 12986, 83, 69 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

LrgA/CidA family

LrgA/CidA

1

IPR005539

5,539

ELK domain

ELK_dom

Domain

9,271

false

Homeobox genes, which encode homeodomain (HD) transcription factors, are known to be key regulators of both plant and animal development. In plants homeobox genes are divided into several groups by sequences, one of which is the KNOX (for knotted1-type homeobox) family. Proteins of this family share other conserved dom...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03789", "PS51213", "SM01188" ]

[ "ELK", "ELK", "ELK" ]

[ 6900, 7744, 8476 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51213", "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5576890", "R-HSA-5576893", "R-HSA-5620912", "R-HSA-6802952", "R-HSA-8854518" ]

[ "PROSITEDOC:PDOC51213", "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5576890", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-8854518" ]

11

[]

0

[ "PUB00008432", "PUB00033717", "PUB00033718", "PUB00033719" ]

[ "11549765", "7866030", "10449577", "12034492" ]

[ "Functional analysis of the conserved domains of a rice KNOX homeodomain protein, OSH15.", "Sequence analysis and expression patterns divide the maize knotted1-like homeobox genes into two classes.", "The conserved KNOX domain mediates specificity of tobacco KNOTTED1-type homeodomain proteins.", "Organ-specif...

[ 2001, 1994, 1999, 2002 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 15, 9254, 2 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 8, 16, 1, 40, 98 ]

6

true

Domain

ELK domain

ELK_dom

5

IPR005540

5,540

KNOX1

Domain

8,334

false

The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization [ ].

[ "GO:0003677", "GO:0005634" ]

[ "DNA binding", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF03790", "SM01255" ]

[ "KNOX1", "KNOX1" ]

[ 8283, 8118 ]

2

[]

0

[]

0

[ "PUB00008432" ]

[ "11549765" ]

[ "Functional analysis of the conserved domains of a rice KNOX homeodomain protein, OSH15." ]

[ 2001 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 8334 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 60, 30, 86 ]

3

true

Domain

KNOX1

3

IPR005541

5,541

KNOX2

Domain

8,439

false

The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization [ ].

[ "GO:0003677", "GO:0005634" ]

[ "DNA binding", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF03791", "SM01256" ]

[ "KNOX2", "KNOX2" ]

[ 8394, 7255 ]

2

[]

0

[]

0

[ "PUB00008432" ]

[ "11549765" ]

[ "Functional analysis of the conserved domains of a rice KNOX homeodomain protein, OSH15." ]

[ 2001 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 8439 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 33, 89 ]

3

true

Domain

KNOX2

6

IPR005542

5,542

PBX, PBC domain

PBX_PBC_dom

Domain

7,275

false

Pbx proteins are members of the TALE (three-amino-acid loop extension) family of atypical homeodomain proteins, whose members are characterised by a three-residue insertion between helix 1 and 2 and plays essential roles during embryonic development by participating in interactive TF networks. The heterodimerization of...

[ "GO:0003700", "GO:0005634" ]

[ "DNA-binding transcription factor activity", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PROFILE" ]

[ "PF03792", "PS51978" ]

[ "PBC", "PBC" ]

[ 7183, 7247 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2173795", "R-HSA-452723", "R-HSA-5617472", "R-HSA-9013508" ]

[ "REACTOME:R-CEL-2173795", "REACTOME:R-HSA-452723", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-9013508" ]

4

[]

0

[ "PUB00007871", "PUB00020003", "PUB00075495", "PUB00100922", "PUB00100923" ]

[ "1363814", "9336443", "17665086", "12505987", "30396330" ]

[ "New motif in PBX genes.", "Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.", "Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution.", "PBX1 nuclear export is regu...

[ 1992, 1997, 2007, 2003, 2018 ]

5

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 7274, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 41, 2, 32, 23, 21 ]

6

true

Domain

PBX, PBC domain

PBX_PBC_dom

8

IPR005543

5,543

PASTA domain

PASTA_dom

Domain

39,311

false

The PASTA domain (for penicillin-binding protein and serine/threonine kinase associated domain) is an extracellular module of ~70 residues that is found in the C-termini of eukaryotic-like serine/threonine kinases (PSTKs) and high molecular weight penicilin-binding proteins (PBPs). The PASTA domain is distributed mainl...

[]

0

[ "PFAM", "PROFILE", "SMART", "CDD" ]

[ "PF03793", "PS51178", "SM00740", "cd06577" ]

[ "PASTA", "PASTA", "PASTA", "PASTA_pknB" ]

[ 37480, 37210, 34250, 28384 ]

4

[ "EC", "PROSITEDOC" ]

[ "2.7.11.1", "PDOC51178" ]

[ "EC:2.7.11.1", "PROSITEDOC:PDOC51178" ]

2

[ "1k25", "1pmd", "1pyy", "1qme", "1qmf", "1rp5", "2kud", "2kue", "2kuf", "2kui", "2mgv", "2z2l", "2z2m", "2zc3", "2zc4", "3m9g", "3ouv", "3py9", "5e0y", "5e0z", "5e10", "5e12", "5nod", "5oau", "5oiz", "5oj0", "5oj1", "5u47", "7o49", "7o4a", "7o4b", "7o4c"...

34

[ "PUB00007872", "PUB00033752", "PUB00121278", "PUB00121279", "PUB00121280", "PUB00121281" ]

[ "12217513", "10860753", "17148687", "16980473", "16936012", "18442973" ]

[ "The PASTA domain: a beta-lactam-binding domain.", "The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance.", "Serine threonine protein kinases of mycobacterial genus: phylogeny to function.", "The Ser/Thr protein kinas...

[ 2002, 2000, 2007, 2006, 2006, 2008 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 112, 38244, 13, 48, 894 ]

5

[]

0

true

Domain

PASTA domain

PASTA_dom

9

IPR005545

5,545

YCII-related

YCII

Domain

51,442

false

The majority of proteins in this group contain a single copy of this domain, though it is also found as a repeat. A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function. This entry also covers what was previously known as the DGPF domain (COG3795), named after the most conserve...

[]

0

[ "PFAM" ]

[ "PF03795" ]

[ "YCII" ]

[ 51442 ]

1

[]

0

[ "1mwq", "1s7i", "4lbh", "4lbi", "4lbp" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 45, 48431, 2694, 272 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1, 1 ]

3

true

Domain

YCII-related

YCII

5

IPR005546

5,546

Autotransporter beta-domain

Autotransporte_beta

Domain

41,994

false

This entry represents a domain found at the C-terminal of the bacterial autotransporter proteins it occurs in [ ]. Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease [ ]. The protein component th...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03797", "PS51208", "SM00869" ]

[ "Autotransporter", "AUTOTRANSPORTER", "Autotransporter" ]

[ 34065, 40492, 37523 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME" ]

[ "PDOC51208", "R-HSA-9760173", "R-HSA-9927020" ]

[ "PROSITEDOC:PDOC51208", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9927020" ]

3

[ "1uyn", "1uyo", "2qom", "3aeh", "3kvn", "3qq2", "3slj", "3slo", "3slt", "4mee", "7akv", "7rj5", "7tsz", "7tt0", "7tt1", "7tt2", "7tt3", "7tt4", "7tt5", "7tt6", "7tt7", "7ttc", "7ye4", "7ye6", "8bnz", "8bo2", "8q0g", "8qn4", "8qp5", "8qpu", "8spr", "8sqa"...

34

[ "PUB00008434", "PUB00008435" ]

[ "3027577", "9778731" ]

[ "Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease.", "The great escape: structure and function of the autotransporter proteins." ]

[ 1987, 1998 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 41740, 9, 83, 162 ]

4

[ "Escherichia coli (strain K12)" ]

[ 11 ]

1

true

Domain

Autotransporter beta-domain

Autotransporte_beta

1

IPR005548

5,548

Cell division protein FtsQ/DivIB, C-terminal

Cell_div_FtsQ/DivIB_C

Domain

17,232

false

FtsQ is an essential cell division protein. It may link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic [ ]. FtsQ may control the correct divisome assembly [ ]. DivIB is a cell division protein from Gram-p...

[]

0

[ "PFAM" ]

[ "PF03799" ]

[ "FtsQ_DivIB_C" ]

[ 17232 ]

1

[]

0

[ "1yr1", "2alj", "2vh1", "2vh2", "5z2w", "6h9n", "6h9o", "8bh1", "8hhf", "8hhg", "8hhh", "8p1u" ]

12

[ "PUB00060679", "PUB00060680", "PUB00060681", "PUB00060682", "PUB00060683", "PUB00060684" ]

[ "17185541", "19233928", "16936019", "20870765", "10792716", "16936026" ]

[ "Three functional subdomains of the Escherichia coli FtsQ protein are involved in its interaction with the other division proteins.", "Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins.", "Multiple interactions bet...

[ 2007, 2009, 2006, 2010, 2000, 2006 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16892, 21, 319 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Cell division protein FtsQ/DivIB, C-terminal

Cell_div_FtsQ/DivIB_C

9

IPR005550

5,550

Kinetochore protein Ndc80

Kinetochore_Ndc80

Family

3,935

false

Members of this family are components of the mitotic spindle. Ndc80 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle, which is required for chromosome segregation and spindle checkpoint activity [ ,...

[ "GO:0051315", "GO:0031262" ]

[ "attachment of mitotic spindle microtubules to kinetochore", "Ndc80 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR10643" ]

[ "" ]

[ 3935 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-5663220", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025", ...

[ "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-5663220", "REACTOME:R-GGA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-...

23

[ "2igp", "2ve7", "3iz0", "5tcs", "5td8", "7kdf", "8g0p", "8g0q", "8q84", "8q85", "8qau", "8v10", "8v11" ]

13

[ "PUB00008439", "PUB00077598", "PUB00088250", "PUB00088267", "PUB00154934", "PUB00154935", "PUB00154936", "PUB00154937" ]

[ "11266451", "23085020", "15548592", "27851957", "23891108", "25743205", "30409912", "36883282" ]

[ "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.", "The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.", "Hec1 and nuf2 are core components of the kinetochore outer plat...

[ 2001, 2012, 2005, 2016, 2013, 2015, 2019, 2023 ]

8

[]

0

null

[ "Bacillota", "Eukaryota" ]

[ 4, 3931 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 2, 1, 4, 2, 1, 5, 1, 1 ]

9

true

Family

Kinetochore protein Ndc80

Kinetochore_Ndc80

2

IPR005551

5,551

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

CitX

Family

3,131

false

Members of this protein family are annotated as CitX, containing the CitX domain, the domain is also found in the CitXG bifunctional protein, of the citrate lyase system. CitX transfers the prosthetic group 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA to the citrate lyase gamma chain, an acyl carrier protein. This enzym...

[ "GO:0051191" ]

[ "prosthetic group biosynthetic process" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00398", "PF03802", "TIGR03124" ]

[ "CitX", "CitX", "citrate_citX" ]

[ 268, 3131, 2937 ]

3

[ "EC", "GP" ]

[ "2.7.7.61", "GenProp0672" ]

[ "EC:2.7.7.61", "GP:GenProp0672" ]

2

[ "7dcm", "7dcn" ]

2

[]

0

[]

0

null

[ "Aduncisulcus paluster", "Bacteria", "metagenomes" ]

[ 1, 3118, 12 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

CitX

8

IPR005552

5,552

Scramblase

Family

10,285

false

This entry represents phospholipid scramblases. These are plasma membrane proteins, which are conserved from worms to humans. They have been originally identified based on their ability to accelerate the transbilayer movement of phospholipids in a calcium-dependent manner [ ]. Scramblase is palmitoylated and contains a...

[ "GO:0017128", "GO:0017121" ]

[ "phospholipid scramblase activity", "plasma membrane phospholipid scrambling" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03803", "PTHR23248" ]

[ "Scramblase", "" ]

[ 10167, 9970 ]

2

[]

0

[]

0

[ "PUB00008442", "PUB00103899" ]

[ "11487015", "10930526" ]

[ "Unraveling the mysteries of phospholipid scrambling.", "Identification of three new members of the phospholipid scramblase gene family." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1131, 9141, 13 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 6, 12, 23, 10, 25, 18, 6, 27, 1, 1, 14 ]

11

true

Family

Scramblase

7

IPR005553

5,553

Cytoadherence-linked asexual protein

CLAG

Family

531

false

Clag (cytoadherence linked asexual gene) is a malaria surface protein which has been shown to be involved in the binding of Plasmodium falciparum infected erythrocytes to host endothelial cells, a process termed cytoadherence. The cytoadherence phenomenon is associated with the sequestration of infected erythrocytes in...

[ "GO:0020035" ]

[ "adhesion of symbiont to microvasculature" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03805" ]

[ "CLAG" ]

[ 531 ]

1

[]

0

[ "7kiy", "7mrw" ]

2

[]

0

[]

0

null

[ "Apicomplexa" ]

[ 531 ]

1

[]

0

true

Family

Cytoadherence-linked asexual protein

CLAG

5

IPR005554

5,554

NOL6/Upt22

Family

5,281

false

This entry includes NOL6 (or Nrap) from animals and Upt22 from yeasts. Upt22 is a component of the small-subunit processome [ ]. It plays a role in channelling aminoacyl-tRNA to the nuclear tRNA export receptor exportin-t [ ].

[]

0

[ "PANTHER" ]

[ "PTHR17972" ]

[ "" ]

[ 5281 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-DME-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[ "4m5d", "5wlc", "5wyj", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "7ajt", "7aju", "7d4i", "7d5s", "7d5t", "7d63", "7mq8", "7mq9", "7mqa", "7suk", "9n6v"...

42

[ "PUB00035836", "PUB00092569" ]

[ "15590835", "23194188" ]

[ "The small-subunit processome is a ribosome assembly intermediate.", "Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p." ]

[ 2004, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5281 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 5, 4, 1, 5, 8, 1, 1, 14 ]

12

true

Family

NOL6/Upt22

5

IPR005555

5,555

M-factor

Family

14

false

The M-factor is a pheromone produced upon nitrogen starvation in fission yeasts. The production of M-factor is increased by the pheromone signal. The protein undergoes post-translational modification to remove the C-terminal signal peptide, the carboxy-terminal cysteine residue is carboxy-methylated and S-alkylated wit...

[ "GO:0000772" ]

[ "mating pheromone activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03855" ]

[ "M-factor" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00008445" ]

[ "8878833" ]

[ "M-factor, a farnesylated mating factor from the fission yeast Schizosaccharomyces pombe." ]

[ 1996 ]

1

[]

0

null

[ "Schizosaccharomyces" ]

[ 14 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3 ]

1

true

Family

M-factor

7

IPR005556

5,556

SUN family

SUN

Family

2,457

false

This entry represents the Sun family from fungi. In budding yeasts there are four identified members: Nca3, Sim1, Sun4 and Uth. They hey share a common C-terminal domain of 258 amino acids bearing 75-85% identity. These C-terminal regions comprise a putative Fe-binding domain consisting in Cys residues organised in a C...

[]

0

[ "PFAM" ]

[ "PF03856" ]

[ "SUN" ]

[ 2457 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.2.1.-", "PWY-1921", "PWY-5821", "PWY-5976", "PWY-6527", "PWY-6717", "PWY-6735", "PWY-6737", "PWY-6749", "PWY-6784", "PWY-6821", "PWY-6848", "PWY-6855", "PWY-6906", "PWY-6972", "PWY-7056", "PWY-7057", "PWY-7074", "PWY-7091", "PWY-7133", "PWY-7134", "PWY-7256", "PWY-7445...

[ "EC:3.2.1.-", "METACYC:PWY-1921", "METACYC:PWY-5821", "METACYC:PWY-5976", "METACYC:PWY-6527", "METACYC:PWY-6717", "METACYC:PWY-6735", "METACYC:PWY-6737", "METACYC:PWY-6749", "METACYC:PWY-6784", "METACYC:PWY-6821", "METACYC:PWY-6848", "METACYC:PWY-6855", "METACYC:PWY-6906", "METACYC:PWY-6...

31

[]

0

[ "PUB00077092", "PUB00077093" ]

[ "11958935", "24040106" ]

[ "Dual cell wall/mitochondria localization of the 'SUN' family proteins.", "SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level." ]

[ 2002, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2457 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 2, 5, 3, 1 ]

4

true

Family

SUN family

SUN

8

IPR005558

5,558

Crustacean neurohormone H

Crust_neurhormone_H

Domain

74

false

Arthropod express a family of neuropeptides [ ] which so far consist of the following types of neurohormones: Crustacean hyperglycemic hormone (CHH). CHH is primarily involved in blood sugar regulation, but also plays a role in the control of molting and reproduction. Molt-inhibiting hormone (MIH). MIH inhibits Y-organ...

[]

0

[ "PFAM" ]

[ "PF03858" ]

[ "Crust_neuro_H" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00008448", "PUB00009750" ]

[ "3298549", "8590372" ]

[ "Amino acid sequences of neuropeptides in the sinus gland of the land crab Cardisoma carnifex: a novel neuropeptide proteolysis site.", "Molecular biology of neurohormone precursors in the eyestalk of Crustacea." ]

[ 1987, 1995 ]

2

[]

0

null

[ "Decapoda" ]

[ 74 ]

1

[]

0

true

Domain

Crustacean neurohormone H

Crust_neurhormone_H

2

IPR005559

5,559

CG-1 DNA-binding domain

CG-1_dom

Domain

8,437

false

CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite nuclear localisation signal. They are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein [ ]. CG-1 domains are found in CAMTA proteins (for CAlModulin -binding...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03859", "PS51437", "SM01076" ]

[ "CG-1", "CG_1", "CG-1" ]

[ 8240, 8359, 8088 ]

3

[]

0

[]

0

[ "PUB00008449", "PUB00019287" ]

[ "8075408", "11925432" ]

[ "CG-1, a parsley light-induced DNA-binding protein.", "A novel family of calmodulin-binding transcription activators in multicellular organisms." ]

[ 1994, 2002 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 8436, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 31, 1, 65, 8, 13, 6, 21, 10, 73 ]

9

true

Domain

CG-1 DNA-binding domain

CG-1_dom

6

IPR005560

5,560

Uncharacterized cysteine-rich protein YhjQ/Copper storage protein-like

Csp_YhjQ

Repeat

8,039

false

This domain is found in a number of copper storage proteins. It contains a repeat of highly conserved cysteines. The cysteines mostly follow a C-X(2)-C-X(3)-C-X(2)-C-X(3) pattern, though they often appear at other positions in the repeat as well. These residues are involved in copper binding. This domain folds into a f...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03860", "PTHR37310" ]

[ "Csp", "" ]

[ 8039, 7558 ]

2

[]

0

[ "3kav", "3kaw", "3lmf", "4zsv", "4zsx", "4zsz", "5arm", "5arn", "5fig", "5fjd", "5fje", "5nqm", "5nqn", "5nqo", "6ei0", "6ek9", "6q58", "6q6b", "6qvh", "6qyb", "6r01", "6wkt", "6zif", "8r4l", "8r4m", "9e7j", "9gq1", "9gsk" ]

28

[ "PUB00016669", "PUB00161196", "PUB00161197" ]

[ "12625841", "31111982", "27991525" ]

[ "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.", "A Histidine Residue and a Tetranuclear Cuprous-thiolate Cluster Dominate the Copper Loading Landscape of a Copper Storage Protein from Streptomyces lividans.", "Bacterial cytosolic proteins with a high capacity ...

[ 2003, 2019, 2016 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 277, 7697, 33, 2, 30 ]

5

[]

0

true

Repeat

Uncharacterized cysteine-rich protein YhjQ/Copper storage protein-like

Csp_YhjQ

9

IPR005561

5,561

ANTAR domain

ANTAR

Domain

32,107

false

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins [ ]. This domain has been detected in various response regulators of two-component systems, which are structured around two proteins, a histidine kinase and a resp...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03861", "PS50921", "SM01012" ]

[ "ANTAR", "ANTAR", "ANTAR" ]

[ 31373, 30406, 31550 ]

3

[ "PROSITEDOC" ]

[ "PDOC50921" ]

[ "PROSITEDOC:PDOC50921" ]

1

[ "1qo0", "1s8n", "1sd5", "4akk", "6hmj", "6wsh", "6ww6" ]

7

[ "PUB00011193" ]

[ "11796212" ]

[ "ANTAR: an RNA-binding domain in transcription antitermination regulatory proteins." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 31701, 35, 371 ]

3

[]

0

true

Domain

ANTAR domain

ANTAR

4

IPR005562

5,562

SpoVA

Family

6,625

false

Members of this family are all transcribed from the spoVA operon [ ]. Bacillus and Clostridium are two well studied endospore forming bacteria. Spore formation provides a resistance mechanism in response to extreme or unfavourable environmental conditions such as heat, radiation, and chemical agents or nutrient depriva...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03862", "PTHR38450" ]

[ "SpoVAC_SpoVAEB", "" ]

[ 6624, 6543 ]

2

[]

0

[]

0

[ "PUB00008450", "PUB00085057", "PUB00085058" ]

[ "11751839", "24666282", "27044622" ]

[ "The products of the spoVA operon are involved in dipicolinic acid uptake into developing spores of Bacillus subtilis.", "Bacillus subtilis spore protein SpoVAC functions as a mechanosensitive channel.", "Characterization of Clostridium difficile Spores Lacking Either SpoVAC or Dipicolinic Acid Synthetase." ]

[ 2002, 2014, 2016 ]

3

[]

[ "IPR014203", "IPR014204" ]

0

2

0

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Siphoviridae sp. ctj8j9", "unclassified sequences" ]

[ 6560, 1, 1, 63 ]

4

[]

0

true

Family

SpoVA

8

IPR005563

5,563

Assembly protein

A_protein

Family

1,179

false

This entry represents assembly/maturation protein (A-protein, MP) from Enterobacteria phages, including bacteriophage MS2. The single-stranded RNA genome of bacteriophage MS2 is 3,569 nt long and encodes four gene products: maturation protein, coat protein, and lysis and replicase proteins [ ]. The maturation protein i...

[ "GO:0039666" ]

[ "virion attachment to host cell pilus" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03863" ]

[ "Phage_mat-A" ]

[ 1179 ]

1

[]

0

[ "5mnt", "5tc1", "5vlz", "5vm7", "6nm5", "7lhd", "8toc", "8tuw", "8tux", "8tv9", "8tva", "8ucr", "8uej" ]

13

[ "PUB00081385", "PUB00081387", "PUB00081388", "PUB00081389", "PUB00081390", "PUB00081391" ]

[ "1264203", "5237875", "4853028", "16359706", "26608810", "23810697" ]

[ "Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene.", "The reconstitution of infective bacteriophage R17.", "Localization of coliphage MS2 A-protein.", "The MS2 coat protein shell is likely assembled under tension: a novel role for the MS2 bacteriopha...

[ 1976, 1967, 1974, 2006, 2016, 2013 ]

6

[]

0

null

[ "Viruses" ]

[ 1179 ]

1

[]

0

true

Family

Assembly protein

A_protein

3

IPR005564

5,564

Major capsid protein GpE

Major_capsid_GpE

Family

5,669

false

This entry represents the major capsid protein found in bacteriophages. Major capsid protein assembles to form an icosahedral capsid with a T=7 symmetry [ , ]. It plays a role in the stabilisation of the condensed form of the DNA molecule in phage heads [ ]. This protein is also found in bacteria, suggesting prophage m...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_04133", "PF03864" ]

[ "CAPSID_LAMBDA", "Phage_cap_E" ]

[ 1389, 5669 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "3bjq", "3bqw", "6i9e", "6ibc", "6o3h", "6xgp", "6xgq", "7sj5", "7vi9", "7via", "7vii", "7vik", "8g1r", "8k39", "8vji", "8xou", "8xqb", "9c2d", "9c3a", "9cul", "9mjn" ]

21

[ "PUB00008451", "PUB00074285", "PUB00074286" ]

[ "2522554", "2141087", "8411174" ]

[ "Structure and inherent properties of the bacteriophage lambda head shell. VI. DNA-packaging-defective mutants in the major capsid protein.", "Structure and inherent properties of the bacteriophage lambda head shell. VII. Molecular design of the form-determining major capsid protein.", "Structural transitions d...

[ 1989, 1990, 1993 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "metagenomes" ]

[ 4702, 29, 1, 872, 65 ]

5

[]

0

true

Family

Major capsid protein GpE

Major_capsid_GpE

9

IPR005565

5,565

Haemolysin activator HlyB, C-terminal

Hemolysn_activator_HlyB_C

Domain

13,120

false

Haemolysin (HlyA) and related toxins are secreted across both the cytoplasmic and outer membranes of Gram-negative bacteria in a process which proceeds without a periplasmic intermediate. HlyA is directed by an uncleaved C-terminal targeting signal and the HlyD and HlyB translocator proteins [ ].

[]

0

[ "PFAM" ]

[ "PF03865" ]

[ "ShlB" ]

[ 13120 ]

1

[ "GP" ]

[ "GenProp1074" ]

[ "GP:GenProp1074" ]

1

[ "3njt", "4qky", "4ql0", "6wil", "6wim" ]

5

[ "PUB00008452" ]

[ "1419114" ]

[ "The HlyB/HlyD-dependent secretion of toxins by gram-negative bacteria." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctvyM23", "unclassified sequences" ]

[ 12994, 20, 1, 105 ]

4

[]

0

true

Domain

Haemolysin activator HlyB, C-terminal

Hemolysn_activator_HlyB_C

4

IPR005566

5,566

Hydrophobic abundant protein (HAP)

HAP

Family

5

false

This entry represents the homologues of Sporulation-specific hydrophobic abundant protein ( ). Expression of Hydrophobic Abundant protein is thought to be developmentally regulated and possibly involved in spherule cell wall formation [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF03866", "PIRSF022393" ]

[ "HAP", "HAP" ]

[ 5, 3 ]

2

[]

0

[]

0

[ "PUB00008453" ]

[ "3170484" ]

[ "Selective gene expression during sporulation of Physarum polycephalum." ]

[ 1988 ]

1

[]

0

null

[ "Acinetobacter sichuanensis", "Physarum polycephalum" ]

[ 2, 3 ]

2

[]

0

true

Family

Hydrophobic abundant protein (HAP)

HAP

3

IPR005567

5,567

Fushi tarazu, N-terminal

FTZ_N

Domain

62

false

This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represent a category of LXXLL motif-dependent co-activators for nuclear receptors.

[]

0

[ "PFAM" ]

[ "PF03867" ]

[ "FTZ" ]

[ 62 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Diptera" ]

[ 62 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Domain

Fushi tarazu, N-terminal

FTZ_N

3

IPR005568

5,568

Large ribosomal subunit protein uL6, N-terminal

Ribosomal_uL6_N

Domain

3,607

false

This entry represents the N-terminal domain of Large ribosomal subunit protein eL6 and similar eukaryotic proteins. Large ribosomal subunit protein uL6 was previously known as L6. In Escherichia coli, it is located in the aminoacyl-tRNA binding site of the peptidyltransferase centre, and is known to bind directly to 23...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF03868" ]

[ "Ribosomal_L6e_N" ]

[ 3607 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-6791226", "R-HSA-72689", "R-HSA-72706", "R-HSA-72764", "R-HSA-9010553", "R-HSA-96...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-HSA-156827", "REACTOME:R-HSA-156902", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-192823", "REACTOME:R-HSA-24...

41

[ "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "4d5y", "4d67", "4ug0", "4uje", "4v6w", "4v6x", "5aj0", "5lks", "5lzs", "5lzt", "5lzu", "5lzv", "5lzw", "5lzx", "5lzy", "5lzz", "5t2c", "6d90", "6d9j", "6frk", "6ftg", "6fti"...

232

[ "PUB00001241", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "8262035", "11297922", "11290319", "11114498" ]

[ "Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 1993, 2001, 2001, 2000 ]

4

[]

0

null

[ "Eukaryota", "Pantoea vagans" ]

[ 3606, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 14, 1, 2, 12, 3, 1, 8, 2 ]

8

true

Domain

Large ribosomal subunit protein uL6, N-terminal

Ribosomal_uL6_N

9

IPR005569

5,569

Arc-like DNA binding domain

Arc_DNA-bd_dom

Domain

5,047

false

Arc repressor act by the cooperative binding of two Arc repressor dimers to a 21-base-pair operator site. Each Arc dimer uses an antiparallel β-sheet to recognise bases in the major groove [ ].

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03869" ]

[ "Arc" ]

[ 5047 ]

1

[]

0

[ "1arq", "1arr", "1b28", "1baz", "1bdt", "1bdv", "1mnt", "1myk", "1myl", "1nla", "1par", "1qtg", "1u9p", "3qoq", "9pio" ]

15

[ "PUB00008454" ]

[ "8107872" ]

[ "DNA recognition by beta-sheets in the Arc repressor-operator crystal structure." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobrevibacter filiformis", "Viruses", "metagenomes" ]

[ 4930, 6, 1, 79, 31 ]

5

[]

0

true

Domain

Arc-like DNA binding domain

Arc_DNA-bd_dom

5

IPR005571

5,571

RNA polymerase, Rpb5, N-terminal

RNA_pol_Rpb5_N

Domain

6,077

false

Prokaryotes contain a single DNA-dependent RNA polymerase (RNAP; ) that is responsible for the transcription of all genes, while eukaryotes have three classes of RNAPs (I-III) that transcribe different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. Certain subunits...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF03871" ]

[ "RNA_pol_Rpb5_N" ]

[ 6077 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-112382", "R-CEL-113418", "R-CEL-5250924", "R-CEL-5578749", "R-CEL-674695", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-6796648", "R-CEL-6803529", "R-CEL-6807505", "R-CEL-72086", "R-CEL-72163", "R-CEL-72165", "R-CEL-72203", "R-CEL-73762", "R-CEL-73772", "R-CEL-7...

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-113418", "REACTOME:R-CEL-5250924", "REACTOME:R-CEL-5578749", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-6796648", "REACTOME:R-CEL-6803529", "REACTOME:R-CEL-6807505", "REACTOME:R...

191

[ "1dzf", "1i3q", "1i50", "1i6h", "1k83", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "2b63", "2b8k", "2e2h", "2e2i", "2e2j", "2ja5", "2ja6", "2ja7", "2ja8", "2nvq"...

511

[ "PUB00003393", "PUB00004780", "PUB00008455", "PUB00008456", "PUB00008457" ]

[ "10191143", "1729711", "10841537", "10841538", "10784442" ]

[ "RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes.", "Component H of the DNA-dependent RNA polymerases of Archaea is homologous to a subunit shared by the three eucaryal nuclear RNA polymerases.", "Crystal structure of RPB5, a universal eukaryot...

[ 1999, 1992, 2000, 2000, 2000 ]

5

[]

0

null

[ "Eukaryota", "Viruses", "metagenomes" ]

[ 6064, 8, 5 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 1, 3, 1, 4, 4, 1, 12, 10, 1, 1, 12 ]

12

true

Domain

RNA polymerase, Rpb5, N-terminal

RNA_pol_Rpb5_N

5

IPR005572

5,572

Anti sigma-E protein RseA, N-terminal

Anti-sigma_E_RseA_N

Domain

5,677

false

Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters [ ]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmi...

[ "GO:0016989" ]

[ "sigma factor antagonist activity" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF03872", "cd16328" ]

[ "RseA_N", "RseA_N" ]

[ 5625, 5479 ]

2

[]

0

[ "1or7", "6in7", "8z6g" ]

3

[ "PUB00007052" ]

[ "9159523" ]

[ "The sigmaE-mediated response to extracytoplasmic stress in Escherichia coli is transduced by RseA and RseB, two negative regulators of sigmaE." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5602, 9, 66 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Anti sigma-E protein RseA, N-terminal

Anti-sigma_E_RseA_N

2

IPR005573

5,573

Anti sigma-E protein RseA, C-terminal

Anti-sigma_E_RseA_C

Domain

2,979

false

Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters [ ]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmi...

[]

0

[ "PFAM" ]

[ "PF03873" ]

[ "RseA_C" ]

[ 2979 ]

1

[]

0

[ "3m4w", "6in9", "6jau" ]

3

[ "PUB00007052" ]

[ "9159523" ]

[ "The sigmaE-mediated response to extracytoplasmic stress in Escherichia coli is transduced by RseA and RseB, two negative regulators of sigmaE." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "marine sediment metagenome" ]

[ 2973, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Anti sigma-E protein RseA, C-terminal

Anti-sigma_E_RseA_C

1

IPR005575

5,575

Statherin

Family

26

false

Statherin is a 43-residue peptide, secreted by parotid and submandibular glands. Statherin functions biologically to inhibit the nucleation and growth of calcium phosphate minerals. The N terminus of statherin is highly charged, the glutamic acids of which have been shown to be important in the recognition hydroxyapati...

[ "GO:0046848", "GO:0030500", "GO:0042742", "GO:0005576" ]

[ "hydroxyapatite binding", "regulation of bone mineralization", "defense response to bacterium", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PIRSF" ]

[ "PF03875", "PIRSF002565" ]

[ "Statherin", "Statherin" ]

[ 25, 18 ]

2

[]

0

[]

0

[ "PUB00008460", "PUB00073995" ]

[ "1313424", "11293657" ]

[ "Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization.", "The effect of statherin and its shortened analogues on anaerobic bacteria isolated from the oral cavity." ]

[ 1992, 2000 ]

2

[ "IPR030773" ]

[]

1

0

1

[ "Boreoeutheria" ]

[ 26 ]

1

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Statherin

5

IPR005576

5,576

RNA polymerase Rpb7-like , N-terminal

Rpb7-like_N

Domain

10,472

false

Rpb7 is a subunit of eukaryotic RNA polymerase (RNAP) II that is homologous to Rpa43 of RNAP I, Rpc8/Rpc25 of RNP III, and RpoE of archaeal RNAP. Rpb7 binds to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation [ ] and plays a part in transcri...

[ "GO:0006351" ]

[ "DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03876" ]

[ "SHS2_Rpb7-N" ]

[ 10472 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953", "R-BTA-759...

[ "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086", "REACTOME:R-B...

188

[ "1go3", "1nt9", "1pqv", "1wcm", "1y14", "1y1v", "1y1w", "1y1y", "1y77", "2b63", "2b8k", "2c35", "2ckz", "2ja5", "2ja6", "2ja7", "2ja8", "2pmz", "2r7z", "2r92", "2r93", "2rf4", "2vum", "2waq", "2wb1", "2y0s", "3ayh", "3fki", "3h0g", "3h3v", "3hkz", "3hou"...

444

[ "PUB00007873", "PUB00010209", "PUB00057445", "PUB00093697" ]

[ "11741548", "12393749", "15281131", "15544954" ]

[ "Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.", "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.", "The SHS2 module is a common structural theme in functionally diverse p...

[ 2001, 2002, 2004, 2004 ]

4

[]

[ "IPR041901" ]

0

1

0

[ "Archaea", "Eiseniibacteriota bacterium", "Eukaryota", "Megaviricetes", "unclassified sequences" ]

[ 884, 1, 9514, 28, 45 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 2, 5, 2, 7, 6, 3, 8, 12, 3, 3, 13 ]

12

true

Domain

RNA polymerase Rpb7-like , N-terminal

Rpb7-like_N

2

IPR005578

5,578

Yif1 family

Yif1_fam

Family

6,161

false

Yif1 (Yip1 interacting factor) is an integral membrane protein required for membrane fusion of ER derived vesicles [ ]. It also plays a role in the biogenesis of ER derived COPII transport vesicles [ ].

[ "GO:0006888", "GO:0005789" ]

[ "endoplasmic reticulum to Golgi vesicle-mediated transport", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03878", "PTHR14083" ]

[ "YIF1", "" ]

[ 6135, 6059 ]

2

[ "REACTOME" ]

[ "R-HSA-381038" ]

[ "REACTOME:R-HSA-381038" ]

1

[]

0

[ "PUB00033378", "PUB00045173" ]

[ "15659647", "12657649" ]

[ "Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.", "The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles." ]

[ 2005, 2003 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6160, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 3, 8, 13, 9, 1, 7, 15, 1, 1, 14 ]

12

true

Family

Yif1 family

Yif1_fam

2

IPR005579

5,579

Cgr1-like

Family

2,292

false

Cgr1 is involved in nucleolar integrity and is required for processing pre-rRNA for the 60S ribosome subunit. In Saccharomyces cerevisiae, this protein is conserved and contributes to compartmentalisation of nucleolar constituents [ ]. Cgr1 is a small hydrophilic protein and members of this family are coiled-coil prote...

[]

0

[ "PFAM" ]

[ "PF03879" ]

[ "Cgr1" ]

[ 2292 ]

1

[]

0

[ "3jct", "6ft6", "6m62", "6ylg", "6ylh", "7oh3", "7ohq", "7uoo", "7uqb", "7uqz", "7v08", "8i9t", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z", "8ia0", "8pv1", "8pv2", "8pv3", "8pv4", "8pv5", "8pv6", "8pv7", "8pv8", "8pvk", "8pvl" ]

28

[ "PUB00008461", "PUB00044116", "PUB00044117" ]

[ "11932453", "11116400", "11342110" ]

[ "Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis.", "Cgr1p, a novel nucleolar protein encoded by Saccharomyces cerevisiae orf YGL0292w.", "Isolation and expression of a gene (CGR1) regulated during the yeast-hyphal transition in Candida albic...

[ 2002, 2001, 2001 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2292 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1, 1 ]

5

true

Family

Cgr1-like

8

IPR005580

5,580

DEAD box helicase DbpA/CsdA, RNA-binding domain

DbpA/CsdA_RNA-bd_dom

Domain

24,136

false

This RNA binding domain is found at the C terminus of a number of DEAD helicase proteins [ ].

[]

0

[ "PFAM" ]

[ "PF03880" ]

[ "DbpA" ]

[ 24136 ]

1

[ "EC" ]

[ "3.6.4.13" ]

[ "EC:3.6.4.13" ]

1

[ "2g0c", "3moj", "5b88", "7bbb", "7pli", "7pmm", "7pmq" ]

7

[ "PUB00008462" ]

[ "10481020" ]

[ "Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins." ]

[ 1999 ]

1

[]

[ "IPR034415" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 23643, 42, 135, 316 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 2, 1 ]

2

true

Domain

DEAD box helicase DbpA/CsdA, RNA-binding domain

DbpA/CsdA_RNA-bd_dom

8

IPR005582

5,582

Chromosome partition protein MukF

Chromosome_partition_MukF

Family

1,830

false

This family contains MukF, which are proteins involved in chromosome condensation, segregation and cell cycle progression. MukE along with MukF interact with MukB in vivo forming a complex, which is required for chromosome condensation and segregation in Escherichia coli [ ]. The Muk complex appears to be similar to th...

[ "GO:0005509", "GO:0006260", "GO:0007059" ]

[ "calcium ion binding", "DNA replication", "chromosome segregation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01803", "NF003615", "PIRSF018282" ]

[ "MukF", "PRK05260.1", "MukF" ]

[ 1479, 1830, 1550 ]

3

[ "GP" ]

[ "GenProp1180" ]

[ "GP:GenProp1180" ]

1

[ "1t98", "3euh", "3rpu", "7nyw", "7nyx", "7nyy", "7nyz", "7nz0", "7nz2", "7nz3", "7nz4", "9gm6", "9gm7", "9gm8", "9gm9", "9gma", "9gmb", "9gmd" ]

18

[ "PUB00015249", "PUB00015251", "PUB00037686" ]

[ "12065423", "10545099", "15902272" ]

[ "Cell cycle-dependent localization of two novel prokaryotic chromosome segregation and condensation proteins in Bacillus subtilis that interact with SMC protein.", "Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli.", "The MukF subunit of Escherichia coli ...

[ 2002, 1999, 2005 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1827, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chromosome partition protein MukF

Chromosome_partition_MukF

3

IPR005583

5,583

DNA-binding and peroxide stress resistance protein YaaA

YaaA

Family

16,142

false

YaaA (also refer to as DUF328/UPF0246) is involved in DNA recombination and oxidative stress response, being a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause [ ...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00652", "PF03883", "PTHR30283" ]

[ "UPF0246", "H2O2_YaaD", "" ]

[ 11651, 16142, 16037 ]

3

[]

0

[ "5caj" ]

1

[ "PUB00077122", "PUB00152827" ]

[ "21378183", "32796037" ]

[ "The YaaA protein of the Escherichia coli OxyR regulon lessens hydrogen peroxide toxicity by diminishing the amount of intracellular unincorporated iron.", "The DUF328 family member YaaA is a DNA-binding protein with a novel fold." ]

[ 2011, 2020 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Podoviridae sp. ct8mF2", "metagenomes" ]

[ 11, 15579, 232, 1, 319 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA-binding and peroxide stress resistance protein YaaA

YaaA

8

IPR005584

5,584

DNA gyrase inhibitor YacG

DNA_gyrase_inhibitor_YacG

Family

8,023

false

This entry represents the DNA gyrase inhibitor YacG family. E coli. YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase [ ]. YacG has been shown to bind zinc and c...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00649", "PF03884", "PTHR36150" ]

[ "DNA_gyrase_inhibitor_YacG", "YacG", "" ]

[ 7734, 8023, 7785 ]

3

[]

0

[ "1lv3", "4tma" ]

2

[ "PUB00022116", "PUB00060604" ]

[ "12211008", "18586829" ]

[ "NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins.", "YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase." ]

[ 2002, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7959, 7, 57 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA gyrase inhibitor YacG

DNA_gyrase_inhibitor_YacG

2

IPR005585

5,585

Protein of unknown function DUF327

DUF327

Family

2,415

false

The proteins in this family are around 140-170 residues in length. The proteins contain many conserved residues, with the most conserved motifs found in the central and C-terminal region. The function of these proteins is unknown.

[]

0

[ "PFAM" ]

[ "PF03885" ]

[ "DUF327" ]

[ 2415 ]

1

[]

0

[ "2p61", "2qup", "5un5", "5un6", "6y06" ]

5

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "ecological metagenomes" ]

[ 2399, 1, 15 ]

3

[]

0

true

Family

Protein of unknown function DUF327

DUF327

8

IPR005586

5,586

ABC-type transport auxiliary lipoprotein component

ABC_trans_aux

Domain

12,027

false

This domain is found in a group of bacterial proteins that act as auxiliaries to the ABC-transporter in the gamma-hexachlorocyclohexane uptake permease system in Sphingobium japonicum. Gamma-hexachlorocyclohexane, or Lindane, can be used as the sole source of carbon in S.japonicum in aerobic conditions. Lindane is an i...

[]

0

[ "PFAM" ]

[ "PF03886" ]

[ "ABC_trans_aux" ]

[ 12027 ]

1

[]

0

[ "2iqi", "6osx", "8q2c", "8q2d" ]

4

[ "PUB00075438" ]

[ "17369300" ]

[ "Identification and characterization of genes encoding a putative ABC-type transporter essential for utilization of gamma-hexachlorocyclohexane in Sphingobium japonicum UT26." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11917, 10, 100 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

ABC-type transport auxiliary lipoprotein component

ABC_trans_aux

3

IPR005587

5,587

Uncharacterised protein family UPF0304, YfbU

UPF0304_YfbU

Family

1,932

false

This is a family of functionally uncharacterised proteins with a length of about 160 residues. A member of this family, E. coli protein YfbU, has been structurally characterised and adopts an α-helical structure consisting of two subdomains. It forms a 24-subunit particle with an empty cavity. The N-terminal subdomains...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_00762", "NF003936", "PF03887", "PIRSF006272" ]

[ "UPF0304", "PRK05445.1", "YfbU", "UCP006272" ]

[ 1333, 1541, 1932, 1330 ]

4

[]

0

[ "1wpb", "4lr3" ]

2

[ "PUB00103940" ]

[ "24816117" ]

[ "Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Methanococcales", "Pezizomycotina", "metagenomes" ]

[ 1919, 3, 4, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0304, YfbU

UPF0304_YfbU

8

IPR005590

5,590

Protein of unknown function DUF333

DUF333

Family

3,649

false

This family consists of functionally uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF03891" ]

[ "DUF333" ]

[ 3649 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctfvB24", "metagenomes" ]

[ 44, 3564, 20, 1, 20 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF333

DUF333

5

IPR005591

5,591

Nitrate reductase cytochrome c-type subunit NapB

NapB

Family

3,105

false

The napB gene encodes a dihaem cytochrome c, the small subunit of a heterodimeric periplasmic nitrate reductase. The NapB protein is essential in transferring electrons to the large catalytic subunit NapA, which subsequently reduces nitrate to nitrite. [ ].

[ "GO:0009061" ]

[ "anaerobic respiration" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03892", "PIRSF006105", "PTHR38604" ]

[ "NapB", "NapB", "" ]

[ 3105, 2586, 2976 ]

3

[ "GP" ]

[ "GenProp1504" ]

[ "GP:GenProp1504" ]

1

[ "1jni", "1ogy", "3ml1", "3o5a" ]

4

[ "PUB00008465" ]

[ "11389694" ]

[ "Overproduction, purification and novel redox properties of the dihaem cytochrome c, NapB, from Haemophilus influenzae." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3074, 2, 29 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Nitrate reductase cytochrome c-type subunit NapB

NapB

2

IPR005592

5,592

Mono-/di-acylglycerol lipase, N-terminal

Mono/diacylglycerol_lipase_N

Domain

4,001

false

This N-terminal region is found in a family of mono-and diacylglycerol lipases.

[ "GO:0016042" ]

[ "lipid catabolic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03893" ]

[ "Lipase3_N" ]

[ 4001 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.1.-", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", "PWY-7769", "PWY-7982", "PWY-8058", "PWY-8143...

[ "EC:3.1.1.-", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", "METACYC:PWY-7367", "METACYC:PWY-7521", "METACYC:PWY-7...

28

[ "1dt3", "1dt5", "1dte", "1du4", "1ein", "1gt6", "1tia", "1tib", "3o0d", "4dyh", "4ea6", "4flf", "4gbg", "4ghw", "4gi1", "4glb", "4gwl", "4jei", "4kjx", "4n8s", "4s0x", "4zgb", "5ap9", "5ch8", "5xk2", "6hw1", "6l7n", "6o8v", "6o9f", "6or3", "6osz", "6unv"...

37

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4001 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 29, 18, 23 ]

3

true

Domain

Mono-/di-acylglycerol lipase, N-terminal

Mono/diacylglycerol_lipase_N

9

IPR005593

5,593

Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase

Xul5P/Fru6P_PKetolase

Family

11,210

false

Phosphoketolases (PK) are key enzymes of the pentose phosphate pathway of heterofermentative and facultative homofermentative lactic acid bacteria and of the D-fructose 6-phosphate shunt of bifidobacteria. PK activity has been sporadically reported in other microorganisms including eukaryotic yeasts. Xylulose-5-phospha...

[ "GO:0016832", "GO:0005975" ]

[ "aldehyde-lyase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03894", "PIRSF017245", "PTHR31273" ]

[ "XFP", "Phosphoketolase", "" ]

[ 10760, 9754, 11193 ]

3

[ "EC", "METACYC", "METACYC", "PROSITEDOC" ]

[ "4.1.2.-", "PWY-7085", "PWY-7089", "PDOC60002" ]

[ "EC:4.1.2.-", "METACYC:PWY-7085", "METACYC:PWY-7089", "PROSITEDOC:PDOC60002" ]

4

[ "3ahc", "3ahd", "3ahe", "3ahf", "3ahg", "3ahh", "3ahi", "3ahj", "3ai7", "6gua", "6lxv", "7c8h", "7c8i", "8io6", "8io7", "8io8", "8io9", "8ioa", "8ioe", "9cd3", "9cd4" ]

21

[ "PUB00008466", "PUB00045300" ]

[ "11292814", "15899413" ]

[ "Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis.", "The gene encoding xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (xfp) is conserved among Bifidobacterium species within a more variable region of the genome and both are us...

[ 2001, 2005 ]

2

[]

[ "IPR023962" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 9109, 2016, 85 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase

Xul5P/Fru6P_PKetolase

7

IPR005594

5,594

Trimeric autotransporter adhesin YadA-like, C-terminal membrane anchor domain

YadA_C

Domain

9,184

false

The Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin of enteric yersiniae. It consists of three major domains: a head mediating adherence to host cells, a stalk involved in serum resistance, and an anchor that forms a membrane pore and is responsible for the autotransport function [ ]. This entry represe...

[]

0

[ "PFAM" ]

[ "PF03895" ]

[ "YadA_anchor" ]

[ 9184 ]

1

[]

0

[ "2gr7", "2gr8", "2lme", "3emo", "9gh4", "9gh5", "9vnj" ]

7

[ "PUB00008467", "PUB00095166" ]

[ "11705900", "17921300" ]

[ "Nonimmune binding of human immunoglobulin A (IgA) and IgG Fc by distinct sequence segments of the EibF cell surface protein of Escherichia coli.", "A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport." ]

[ 2001, 2007 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 9087, 69, 9, 19 ]

4

[]

0

true

Domain

Trimeric autotransporter adhesin YadA-like, C-terminal membrane anchor domain

YadA_C

4

IPR005595

5,595

Translocon-associated protein (TRAP), alpha subunit

TRAP_alpha

Family

5,705

false

The alpha-subunit of the TRAP (translocon-associated protein, also known as signal sequence receptor 1/alpha subunit, SSRA) complex is a single-spanning membrane protein of the endoplasmic reticulum (ER) [ , ]. The four-subunit (alpha, beta, gamma and delta) TRAP complex localises in the ER membrane and associates with...

[ "GO:0005789" ]

[ "endoplasmic reticulum membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03896" ]

[ "TRAP_alpha" ]

[ 5705 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-1799339", "R-HSA-381038" ]

[ "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-381038" ]

2

[ "8b5l", "8b6l", "8bf9", "8btk", "8rjc", "8rjd", "9i78" ]

7

[ "PUB00008468", "PUB00070947", "PUB00070948", "PUB00070949", "PUB00101524" ]

[ "8050590", "17380188", "15811380", "22314232", "31840061" ]

[ "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges.", "Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.", "Architecture of the ribosome-channel complex derived from native membranes.", "Palmitoylat...

[ 1994, 2007, 2005, 2012, 2019 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5705 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 2, 1, 9, 6, 1, 2, 7, 1, 12 ]

11

true

Family

Translocon-associated protein (TRAP), alpha subunit

TRAP_alpha

7

IPR005597

5,597

Satellite tobacco necrosis virus coat protein-like

Satellite_CP-like

Family

7

false

This entry represents the virus coat protein found in satellite tobacco necrosis virus, and maize white line mosaic Satellite virus. The protein contains a "jelly-roll" motif. The narrow end of the jelly roll is thought to form fivefold contacts organised about a Ca2+ ion [ ].

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PIRSF", "CDD" ]

[ "PIRSF004094", "cd00259" ]

[ "Satellite_CP", "STNV" ]

[ 4, 7 ]

2

[]

0

[ "2buk", "3s4g", "4bcu", "4v4m", "8qkm", "9qve" ]

6

[ "PUB00007874" ]

[ "8553559" ]

[ "Structural comparison of the plant satellite viruses." ]

[ 1995 ]

1

[ "IPR010392" ]

[]

1

0

1

[ "Riboviria incertae sedis" ]

[ 7 ]

1

[]

0

true

Family

Satellite tobacco necrosis virus coat protein-like

Satellite_CP-like

1

IPR005598

5,598

ATP synthase protein I

ATP_synth_I

Family

9,026

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[]

0

[ "PFAM" ]

[ "PF03899" ]

[ "ATP-synt_I" ]

[ 9026 ]

1

[]

0

[]

0

[ "PUB00009752", "PUB00011540", "PUB00013531", "PUB00020603", "PUB00020604", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00088863" ]

[ "11309608", "7961438", "12917488", "15473999", "15078220", "20450191", "18937357", "1385979", "9741106", "23123906" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "Bacillus subtilis F0F1 ATPase: DNA sequence of the atp operon and characterization of atp mutants.", "A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg2+ uptake.", "The evoluti...

[ 2001, 1994, 2003, 2004, 2004, 2010, 2008, 1992, 1998, 2013 ]

10

[]

[ "IPR039072" ]

0

1

0

[ "Bacteria", "Malvaceae", "unclassified sequences" ]

[ 8894, 4, 128 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ATP synthase protein I

ATP_synth_I

5

IPR005599

5,599

GPI mannosyltransferase

GPI_mannosylTrfase

Family

17,405

false

Members of this family are glycosylphosphatidylinositol mannosyltransferase enzymes [ec:2.4.1.-] [ , ]. At least some members are localised in endoplasmic reticulum and involved in glycosyl phosphatidyl inositol (GPI) anchor biosynthesis [ , ]. In Arabidopsis, mannosyltransferase APTG1 (Abnormal Pollen Tube Guidance1) ...

[ "GO:0016757" ]

[ "glycosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03901", "PTHR22760" ]

[ "Glyco_transf_22", "" ]

[ 17324, 16854 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.4.1", "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", ...

[ "EC:2.4.1", "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", ...

216

[]

0

[ "PUB00008470", "PUB00014490", "PUB00014491", "PUB00014492", "PUB00014493", "PUB00094555" ]

[ "2005867", "9576863", "10954751", "12200473", "12030331", "24963069" ]

[ "Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1.", "Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis.", "Critical roles of glycosylphosphatidylinositol for Try...

[ 1991, 1998, 2000, 2002, 2002, 2014 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 10, 486, 16906, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 3, 5, 4, 20, 9, 4, 9, 21, 4, 4, 52 ]

12

true

Family

GPI mannosyltransferase

GPI_mannosylTrfase

4

IPR005600

5,600

Gal4 dimerisation domain

Gal4_dimer_dom

Domain

913

false

The DNA binding domain (residues 1 to 147) of the yeast transcriptional activator GAL4 exists in solution in dimeric form, with the region responsible for dimerisation somewhere between residues 74 and 147. Experimental studies confirmed that the 'hydrophobic region' of the protein (residues 54-97, which contains a lar...

[]

0

[ "PFAM", "CDD" ]

[ "PF03902", "cd14654" ]

[ "Gal4_dimer", "ZIP_Gal4" ]

[ 428, 879 ]

2

[]

0

[ "1d66", "1hbw", "3coq", "7uik", "7uio" ]

5

[ "PUB00007875" ]

[ "8765712" ]

[ "A physico-chemical investigation of the self-association of the DNA binding domain of the yeast transcriptional activator GAL4." ]

[ 1996 ]

1

[]

0

null

[ "Dikarya" ]

[ 913 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Gal4 dimerisation domain

Gal4_dimer_dom

9

IPR005601

5,601

Tail fibre protein p36

Tail_fibre_p36

Family

301

false

Irreversible binding of T-even bacteriophages to Escherichia coli is mediated by the short and long tail fibres, which serve as inextensible stays during DNA injection. Short tail fibres are exceptionally stable elongated trimers of gene product 12 (gp12), a 56kDa protein. The N-terminal region of gp12 is important for...

[]

0

[ "PFAM" ]

[ "PF03903" ]

[ "Phage_T4_gp36" ]

[ 301 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00074569", "PUB00094388" ]

[ "4000929", "29204885" ]

[ "The nucleotide sequences of the tail fiber gene 36 of bacteriophage T2 and of genes 36 of the T-even type Escherichia coli phages K3 and Ox2.", "Bacteriophage T4 long tail fiber domains." ]

[ 1985, 2018 ]

2

[]

0

null

[ "Bacteria", "Viruses" ]

[ 93, 208 ]

2

[]

0

true

Family

Tail fibre protein p36

Tail_fibre_p36

7

IPR005602

5,602

Protein of unknown function DUF334

DUF334

Family

62

false

This is a family of proteins found in Staphylococcus aureus plasmid with no characterised function.

[]

0

[ "PFAM" ]

[ "PF03904" ]

[ "DUF334" ]

[ 62 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 61, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF334

DUF334

8

IPR005603

5,603

Coronavirus nonstructural protein NS4

Corona_NS4

Family

97

false

This non-structural protein does not appear to be essential for viral growth in tissue culture and its physiological role is unknown.

[]

0

[ "PFAM" ]

[ "PF03905" ]

[ "Corona_NS4" ]

[ 97 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Coronaviridae" ]

[ 97 ]

1

[]

0

true

Family

Coronavirus nonstructural protein NS4

Corona_NS4

9

IPR005604

5,604

Bacteriophage T7 tail fibre protein-like, N-terminal domain

Phage_T7_tail_fibre-like_N

Domain

1,045

false

The bacteriophage T7 tail complex consists of a conical tail-tube surrounded by six kinked tail-fibres, which are oligomers of the viral protein gp17. The tail spike protein of bacteriophage K1F is important for the initial absorption of the phage into its host bacterium by hydrolysing the alpha-sialosyl linkages in th...

[]

0

[ "PFAM" ]

[ "PF03906" ]

[ "Phage_T7_tail" ]

[ 1045 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "7boz", "7ey7", "7ey9", "7xy1", "7y1c", "7y22", "8dsp", "8e4g", "8es4", "8i4m", "8vbx", "8x8m", "8x8o", "9jyz", "9jz0", "9vvr" ]

16

[ "PUB00082574", "PUB00151527" ]

[ "20096705", "32266588" ]

[ "Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF.", "Structural changes of a bacteriophage upon DNA packaging and maturation." ]

[ 2010, 2020 ]

2

[]

0

null

[ "Bacteria", "Viruses", "unclassified sequences" ]

[ 120, 916, 9 ]

3

[]

0

true

Domain

Bacteriophage T7 tail fibre protein-like, N-terminal domain

Phage_T7_tail_fibre-like_N

4

IPR005605

5,605

Sporulation-specific protein Spo7

Spo7

Family

1,621

false

In budding yeasts, Spo7 is part of the Nem1-Spo7 protein phosphatase complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 [ ]. The Nem1-Spo7 complex mediates regulation of membrane biogenesis is needed to promote mitophagy in yeast [ ].

[ "GO:0019888" ]

[ "protein phosphatase regulator activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03907", "PTHR28249" ]

[ "Spo7", "" ]

[ 1620, 1191 ]

2

[ "REACTOME" ]

[ "R-SPO-4419969" ]

[ "REACTOME:R-SPO-4419969" ]

1

[]

0

[ "PUB00059932", "PUB00092542" ]

[ "15889145", "29305265" ]

[ "The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.", "The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast." ]

[ 2005, 2018 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1621 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Sporulation-specific protein Spo7

Spo7

5

IPR005607

5,607

BSD domain

BSD_dom

Domain

16,263

false

The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from pri...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03909", "PS50858", "SM00751" ]

[ "BSD", "BSD", "BSD" ]

[ 15336, 16007, 14897 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50858", "R-DDI-113418", "R-DDI-5696395", "R-DDI-674695", "R-DDI-6781823", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-6796648", "R-DDI-72086", "R-DDI-73772", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-DDI-77075", "R-DME-112382", "R-DME-113418", "R-DME-5696395"...

[ "PROSITEDOC:PDOC50858", "REACTOME:R-DDI-113418", "REACTOME:R-DDI-5696395", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6781823", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-6796648", "REACTOME:R-DDI-72086", "REACTOME:R-DDI-73772", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73...

108

[ "1x3a", "2dii", "5oqj", "5oqm", "6gym", "6nmi", "6o9l", "6o9m", "7ad8", "7bul", "7egb", "7egc", "7ena", "7enc", "7k01", "7k04", "7lbm", "7m2u", "7ml0", "7ml1", "7ml2", "7ml3", "7ml4", "7nvr", "7nvw", "7nvx", "7nvy", "7nvz", "7nw0", "7o4i", "7o4j", "7o4k"...

64

[ "PUB00011833" ]

[ "11943536" ]

[ "BSD: a novel domain in transcription factors and synapse-associated proteins." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Escherichia phage SRT8", "Eukaryota" ]

[ 33, 1, 1, 16228 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 59, 4, 10, 7, 15, 7, 2, 27, 11, 2, 2, 40 ]

12

true

Domain

BSD domain

BSD_dom

9

IPR005608

5,608

Adenovirus core-capsid bridging protein V

Adeno_V

Family

382

false

The Adenoviruses nucleoprotein core consists of genomic dsDNA and six proteins. Protein V is one of the most important proteins in the core due to its involvement in core condensation. Protein V also bridges the viral DNA core with the outer capsid by interacting with protein VI. It plays an important role in capsid as...

[ "GO:0003677", "GO:0044423" ]

[ "DNA binding", "virion component" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_04053", "PF03910" ]

[ "ADV_CORE5", "Adeno_PV" ]

[ 142, 382 ]

2

[]

0

[ "6z7n", "9lr9" ]

2

[ "PUB00087143", "PUB00087144" ]

[ "24899200", "25071205" ]

[ "Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V.", "Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection." ]

[ 2014, 2014 ]

2

[]

0

null

[ "Adenoviridae", "Mycobacterium simiae" ]

[ 381, 1 ]

2

[]

0

true

Family

Adenovirus core-capsid bridging protein V

Adeno_V

2

IPR005610

5,610

Photosystem II Psb28, class 1

PSII_Psb28_class-1

Family

1,734

false

This family represents the low molecular weight transmembrane protein Psb28 (PsbW), one of the assembly factors of photosystem II (PSII). Psb28 is involved in guiding PSII biogenesis and assembly, stabilising dimeric PSII [ , ], and facilitating PSII repair after photo-inhibition [ ]. When Psb28 binds the membrane-intr...

[ "GO:0015979", "GO:0009523", "GO:0009654", "GO:0016020" ]

[ "photosynthesis", "photosystem II", "photosystem II oxygen evolving complex", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component", "cellular_component" ]

4

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01370", "PF03912", "PTHR34963", "TIGR03047" ]

[ "PSII_Psb28", "Psb28", "", "PS_II_psb28" ]

[ 1435, 1730, 1685, 1701 ]

4

[ "GP" ]

[ "GenProp0661" ]

[ "GP:GenProp0661" ]

1

[ "2kvo", "3zpn", "6jlu", "7dxa", "7dxh", "7nhp", "7nhq", "8j5k" ]

8

[ "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015376", "PUB00015377", "PUB00097583", "PUB00152828" ]

[ "12518057", "15100025", "14871485", "10950961", "9335523", "30076221", "33846594" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement of photosystem 2.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "The low molecular mass PsbW protein ...

[ 2003, 2004, 2004, 2000, 1997, 2018, 2021 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured marine microorganism" ]

[ 569, 1148, 17 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 14 ]

3

true

Family

Photosystem II Psb28, class 1

PSII_Psb28_class-1

5

IPR005611

5,611

Amb V Allergen

Amb_V_allergen

Family

4

false

Amb V is an Ambrosia sp (ragweed) pollen allergen. Amb t V has been shown to contain a C-terminal helix as the major T cell epitope. Free sulphydryl groups also play a major role in the T cell recognition of cross-reactivity T cell epitopes within these related allergens [ ].

[]

0

[ "PFAM", "PIRSF", "SMART" ]

[ "PF03913", "PIRSF002697", "SM00816" ]

[ "Ragweed_pollen", "Amb_V_allergen", "Amb_V_allergen" ]

[ 4, 4, 4 ]

3

[]

0

[ "1bbg", "2bbg", "3bbg" ]

3

[ "PUB00007876" ]

[ "7594515" ]

[ "T cell epitope mapping of ragweed pollen allergen Ambrosia artemisiifolia (Amb a 5) and Ambrosia trifida (Amb t 5) and the role of free sulfhydryl groups in T cell recognition." ]

[ 1995 ]

1

[]

0

null

[ "Ambrosia" ]

[ 4 ]

1

[]

0

true

Family

Amb V Allergen

Amb_V_allergen

2

IPR005612

5,612

CCAAT-binding factor

CCAAT-binding_factor

Domain

13,676

false

This domain is present in the CAATT-binding protein which is essential for growth and necessary for 60S ribosomal subunit biogenesis. Other proteins containing this domain stimulate transcription from the HSP70 promoter.

[]

0

[ "PFAM" ]

[ "PF03914" ]

[ "CBF" ]

[ 13676 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-CEL-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

7

[ "5wlc", "6elz", "6em5", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqu", "6lqv", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "6zqg", "7ajt", "7aju", "7d4i", "7d5s", "7d63", "7mq8", "7mq9", "7mqa", "7nac"...

69

[]

0

[]

0

null

[ "Eukaryota" ]

[ 13676 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 3, 5, 4, 6, 6, 3, 10, 11, 3, 3, 43 ]

12

true

Domain

CCAAT-binding factor

CCAAT-binding_factor

6

IPR005613

5,613

Actin interacting protein 3, C-terminal

AIP3_C

Domain

1,941

false

This entry represents the C-terminal domain of actin interacting protein 3 (also known as Bud6 in budding yeasts). Bud6 is an actin-and formin-interacting protein. The N-terminal half of Bud6 is a microtubule binding domain required for its localisation and for its function in cortical capture of astral microtubule end...

[ "GO:0005519" ]

[ "cytoskeletal regulatory protein binding" ]

[ "molecular_function" ]

1

[ "SMART" ]

[ "SM00806" ]

[ "AIP3" ]

[ 1941 ]

1

[]

0

[ "3okq", "3onx" ]

2

[ "PUB00063966" ]

[ "23161908" ]

[ "Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6." ]

[ 2012 ]

1

[ "IPR022782" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1941 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Actin interacting protein 3, C-terminal

AIP3_C

9

IPR005614

5,614

NrfD-like

Family

13,130

false

This entry includes a group of integral membrane proteins that transfer of electrons from the quinone pool to the type-c cytochromes, found in bacteria and archaea. NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, ...

[]

0

[ "PFAM" ]

[ "PF03916" ]

[ "NrfD" ]

[ 13130 ]

1

[ "GP", "GP" ]

[ "GenProp1582", "GenProp1672" ]

[ "GP:GenProp1582", "GP:GenProp1672" ]

2

[ "6btm", "6f0k", "6lod", "6loe", "8k9e", "8k9f", "8x2j", "9ilt" ]

8

[ "PUB00006649", "PUB00060545" ]

[ "8057835", "21357486" ]

[ "A seven-gene operon essential for formate-dependent nitrite reduction to ammonia by enteric bacteria.", "Molecular cloning and characterization of the srdBCA operon, encoding the respiratory selenate reductase complex, from the selenate-reducing bacterium Bacillus selenatarsenatis SF-1." ]

[ 1994, 2011 ]

2

[]

[ "IPR052049", "IPR054823" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 586, 12202, 9, 333 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

NrfD-like

6

IPR005615

5,615

Glutathione synthase

Glutathione_synthase

Family

7,151

false

This entry represents glutathione synthetase ( ) (GSH-S), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synth...

[ "GO:0004363", "GO:0005524", "GO:0006750" ]

[ "glutathione synthase activity", "ATP binding", "glutathione biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "PF03917", "PIRSF001558", "PTHR11130", "TIGR01986", "cd00228" ]

[ "GSH_synth_ATP", "GSHase", "", "glut_syn_euk", "eu-GS" ]

[ 7076, 5598, 7041, 4718, 838 ]

5

[ "EC", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.2.3", "GenProp0030", "GenProp1359", "GenProp1664", "PWY-8043", "R-DDI-174403", "R-HSA-174403", "R-HSA-5579006", "R-MMU-174403", "R-RNO-174403", "R-SCE-174403", "R-SPO-174403" ]

[ "EC:6.3.2.3", "GP:GenProp0030", "GP:GenProp1359", "GP:GenProp1664", "METACYC:PWY-8043", "REACTOME:R-DDI-174403", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-5579006", "REACTOME:R-MMU-174403", "REACTOME:R-RNO-174403", "REACTOME:R-SCE-174403", "REACTOME:R-SPO-174403" ]

12

[ "1m0t", "1m0w", "2hgs", "2wyo", "3kaj", "3kak", "3kal", "5oes", "5oet", "5oeu", "5oev", "8fbz" ]

12

[ "PUB00035960", "PUB00100287" ]

[ "15981742", "9215686" ]

[ "Physiological and pathological aspects of GSH metabolism.", "Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction." ]

[ 2005, 1997 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 267, 6877, 7 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 7, 13, 9, 2, 17, 6, 1, 1, 44 ]

12

true

Family

Glutathione synthase

Glutathione_synthase

6

IPR005616

5,616

CcmH/CycL/Ccl2/NrfF, N-terminal

CcmH/CycL/Ccl2/NrfF_N

Domain

13,230

false

Cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes. CcmH consists of an N-terminal catalytic domain with the active site CXXC motif, exposed to the periplasm, and a C-terminal domain of unknown function which is predicted to co...

[]

0

[ "PFAM", "CDD" ]

[ "PF03918", "cd16378" ]

[ "CcmH", "CcmH_N" ]

[ 13228, 12695 ]

2

[ "GP" ]

[ "GenProp0678" ]

[ "GP:GenProp0678" ]

1

[ "2hl7", "2kw0" ]

2

[ "PUB00019270", "PUB00047615", "PUB00047616", "PUB00062035", "PUB00066045", "PUB00080820", "PUB00095480", "PUB00136432" ]

[ "9914305", "17623665", "16236729", "8842153", "22789558", "12196152", "18644794", "18687332" ]

[ "Characterization of the Escherichia coli CcmH protein reveals new insights into the redox pathway required for cytochrome c maturation.", "A strategic protein in cytochrome c maturation: three-dimensional structure of CcmH and binding to apocytochrome c.", "AtCCMH, an essential component of the c-type cytochro...

[ 1999, 2007, 2005, 1996, 2012, 2002, 2008, 2008 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 12308, 639, 16, 267 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 1, 2 ]

4

true

Domain

CcmH/CycL/Ccl2/NrfF, N-terminal

CcmH/CycL/Ccl2/NrfF_N

3

IPR005617

5,617

Groucho/TLE, N-terminal Q-rich domain

Groucho/TLE_N

Domain

11,296

false

The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerisation.

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03920" ]

[ "TLE_N" ]

[ 11296 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-201722", "R-CEL-3769402", "R-CEL-4641265", "R-CEL-9764725", "R-DME-201722", "R-DME-209421", "R-DME-209441", "R-DME-3769402", "R-DME-4641265", "R-DME-9764725", "R-DRE-3769402", "R-DRE-4641265", "R-DRE-9018519", "R-HSA-201722", "R-HSA-2122947", "R-HSA-3769402", "R-HSA-4641265", ...

[ "REACTOME:R-CEL-201722", "REACTOME:R-CEL-3769402", "REACTOME:R-CEL-4641265", "REACTOME:R-CEL-9764725", "REACTOME:R-DME-201722", "REACTOME:R-DME-209421", "REACTOME:R-DME-209441", "REACTOME:R-DME-3769402", "REACTOME:R-DME-4641265", "REACTOME:R-DME-9764725", "REACTOME:R-DRE-3769402", "REACTOME:R-...

28

[ "4om2", "4om3" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 11296 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 44, 6, 40, 33, 39 ]

6

true

Domain

Groucho/TLE, N-terminal Q-rich domain

Groucho/TLE_N

9

IPR005619

5,619

Uncharacterised protein family, YajG

Uncharacterised_YajG

Family

3,399

false

The function of this presumed lipoprotein is unknown. The family includes Escherichia coli YajG .

[]

0

[ "PFAM" ]

[ "PF03923" ]

[ "Lipoprotein_16" ]

[ 3399 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 3382, 7, 10 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family, YajG

Uncharacterised_YajG

5

IPR005621

5,621

Negative modulator of initiation of replication SeqA

SeqA

Family

2,094

false

The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [ ]. SeqA tetramers are able to aggregate ...

[ "GO:0003677", "GO:0032297" ]

[ "DNA binding", "negative regulation of DNA-templated DNA replication initiation" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF" ]

[ "MF_00908", "PIRSF019401" ]

[ "SeqA", "SeqA" ]

[ 1918, 2058 ]

2

[]

0

[ "3fmt" ]

1

[ "PUB00008475", "PUB00008980" ]

[ "11457824", "11442835" ]

[ "SeqA protein aggregation is necessary for SeqA function.", "SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "marine sediment metagenome" ]

[ 2090, 3, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Negative modulator of initiation of replication SeqA

SeqA

6

IPR005623

5,623

Chaperone NapD, nitrate reductase assembly

Chaperone_NapD_NO3_reduct

Family

3,142

false

Periplasmic nitrate reductase (NapABC enzyme) is responsible for nitrate dissimilation [ ]. This entry represents NapD, the twin-arginine signal-peptide-binding chaperone for NapA, functioning as an assembly protein for NapABC which is essential for its activity. It may have a role in the insertion of the NapA molybden...

[]

0

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_02200", "PF03927", "PIRSF020431", "PTHR38603" ]

[ "NapD", "NapD", "UCP020431_NapD", "" ]

[ 2889, 3142, 38, 2523 ]

4

[ "GP" ]

[ "GenProp0127" ]

[ "GP:GenProp0127" ]

1

[ "2jsx", "2pq4" ]

2

[ "PUB00053992", "PUB00088656", "PUB00095287" ]

[ "19060147", "11450112", "24314029" ]

[ "Catabolite repression control of napF (periplasmic nitrate reductase) operon expression in Escherichia coli K-12.", "Nitrate reduction in the periplasm of gram-negative bacteria.", "Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone." ]

[ 2009, 2001, 2014 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3109, 2, 31 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chaperone NapD, nitrate reductase assembly

Chaperone_NapD_NO3_reduct

3

IPR005624

5,624

Corrinoid adenosyltransferase PduO/GlcC-like

PduO/GlcC-like

Domain

22,818

false

This entry includes Protein GlcG from Escherichia coli, Corrinoid adenosyltransferase PduO from Salmonella typhimurium and many uncharacterised proteins from bacteria and fungi. GlcG controls the expression of the genes of the glycolate pathway [ , ]. The structure of GlcG is composed of an α-β(2)-α(3)-β(2)-α fold, sim...

[]

0

[ "PFAM" ]

[ "PF03928" ]

[ "HbpS-like" ]

[ 22818 ]

1

[]

0

[ "2a2l", "3fpv", "3fpw", "4bmw", "4clc", "4nkp", "5cx7", "6bws", "6c0z", "9jth" ]

10

[ "PUB00007282", "PUB00013593", "PUB00052019", "PUB00100245", "PUB00100285", "PUB00100286", "PUB00153673", "PUB00153674" ]

[ "8606183", "11160088", "19244623", "27446048", "9880556", "15547259", "33578755", "34038406" ]

[ "glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein.", "Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.", "The oligomeric assembly of the novel ...

[ 1996, 2001, 2009, 2016, 1999, 2004, 2021, 2021 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Pithoviruses", "Sym plasmid", "unclassified sequences" ]

[ 186, 20117, 2295, 3, 1, 216 ]

6

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Corrinoid adenosyltransferase PduO/GlcC-like

PduO/GlcC-like

6

IPR005625

5,625

PepSY-associated TM protein

PepSY-ass_TM

Family

30,332

false

This family contains proteins of up to five transmembranes helices found in bacterial species, some of which carry a nested PepSY domain. Coil residues are significantly more conserved than other residues and are frequently found within channels and transporters, where they introduce the flexibility and polarity requir...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03929", "PTHR34219" ]

[ "PepSY_TM", "" ]

[ 29996, 26835 ]

2

[]

0

[ "7abw" ]

1

[ "PUB00020015", "PUB00043398" ]

[ "15124630", "18511074" ]

[ "The PepSY domain: a regulator of peptidase activity in the microbial environment?", "Coils in the membrane core are conserved and functionally important." ]

[ 2004, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 30101, 31, 200 ]

3

[]

0

true

Family

PepSY-associated TM protein

PepSY-ass_TM

2

IPR005627

5,627

CutC-like

Family

14,286

false

CutC was originally thought to be involved in copper tolerance in Escherichia coli, as mutation in the corresponding gene lead to an increased copper sensitivity [ ]. However, this phenotype has been later reported to depend on the levels of the mRNA-interfering complementary RNA regulator MicL, which is transcribed fr...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00795", "PF03932", "PTHR12598" ]

[ "CutC", "CutC", "" ]

[ 11026, 14266, 14181 ]

3

[ "REACTOME" ]

[ "R-HSA-936837" ]

[ "REACTOME:R-HSA-936837" ]

1

[ "1twd", "1x7i", "1x8c", "2bdq", "3iwp", "4r9x" ]

6

[ "PUB00009886", "PUB00038243", "PUB00099854", "PUB00099855", "PUB00099856", "PUB00099857" ]

[ "7635807", "15624211", "19878721", "25030700", "26660891", "34616378" ]

[ "Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli.", "Crystal structure of the copper homeostasis protein (CutCm) from Shigella flexneri at 1.7 A resolution: the first structure of a new sequence family of TIM barrels.", "Crystal structure of human copper homeostasis...

[ 1995, 2005, 2010, 2014, 2016, 2021 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 11384, 2840, 62 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 4, 4, 1, 4 ]

8

true

Family

CutC-like

5

IPR005628

5,628

General secretion pathway protein K

GspK

Family

7,353

false

Members of this family are involved in the general secretion pathway required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm, such as GspK. GspK plays a role in pseudo pilus assembly and seems to control its length. It interacts with the pseudopilus tip compl...

[ "GO:0009306", "GO:0016020" ]

[ "protein secretion", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM", "PIRSF", "PANTHER" ]

[ "NF037980", "PIRSF002786", "PTHR38831" ]

[ "T2SS_GspK", "XcpX", "" ]

[ 4901, 5413, 7244 ]

3

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "3ci0", "5vtm", "6utu" ]

3

[ "PUB00002231", "PUB00003843", "PUB00020865", "PUB00059295", "PUB00093998" ]

[ "8407845", "8326859", "2129543", "16012171", "30767847" ]

[ "Isolation and analysis of eight exe genes and their involvement in extracellular protein secretion and outer membrane assembly in Aeromonas hydrophila.", "Molecular cloning and characterization of 13 out genes from Erwinia carotovora subspecies carotovora: genes encoding members of a general secretion pathway (G...

[ 1993, 1993, 1990, 2005, 2019 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7209, 11, 133 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

General secretion pathway protein K

GspK

5

IPR005629

5,629

Beta-glucan synthesis-associated protein Skn1/Kre6/Sbg1

Skn1/Kre6/Sbg1

Family

5,547

false

This family consists of the beta-glucan synthesis-associated proteins SKN1, KRE6 and Sbg1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan, and chitin. SKN1 and KRE6 show similarities to glycoside hydrolase family 16 glycoside hydrolases, suggesting that they...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF03935", "PTHR31361", "cd02180" ]

[ "SKN1_KRE6_Sbg1", "", "GH16_fungal_KRE6_glucanase" ]

[ 5459, 5305, 2179 ]

3

[]

0

[]

0

[ "PUB00016652", "PUB00095437", "PUB00095438", "PUB00095439" ]

[ "10601196", "27898700", "27749909", "15792805" ]

[ "Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae.", "Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast.", "A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.", "SKN1, a novel plan...

[ 1999, 2016, 2016, 2005 ]

4

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "metagenomes" ]

[ 35, 1, 5509, 2 ]

4

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2 ]

2

true

Family

Beta-glucan synthesis-associated protein Skn1/Kre6/Sbg1

Skn1/Kre6/Sbg1

3

IPR005630

5,630

Terpene synthase, metal-binding domain

Terpene_synthase_metal-bd

Domain

23,367

false

Sequences containing this domain belong to the terpene synthase family [ ]. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C 10 ) synthases, sesquiterpene (C 15 ) synthases and the diterpene (C 20 ) synthases. It ha...

[ "GO:0000287", "GO:0010333", "GO:0016829" ]

[ "magnesium ion binding", "terpene synthase activity", "lyase activity" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF03936" ]

[ "Terpene_synth_C" ]

[ 23367 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP" ]

[ "4.2.3", "GenProp1471", "GenProp1638", "GenProp1709", "GenProp1739", "GenProp1760" ]

[ "EC:4.2.3", "GP:GenProp1471", "GP:GenProp1638", "GP:GenProp1709", "GP:GenProp1739", "GP:GenProp1760" ]

6

[ "1hx9", "1hxa", "1hxc", "1hxg", "1n1b", "1n1z", "1n20", "1n21", "1n22", "1n23", "1n24", "2j5c", "2ong", "2onh", "3g4d", "3g4f", "3lz9", "3m00", "3m01", "3m02", "3n0f", "3n0g", "3p5p", "3p5r", "3s9v", "3sae", "3sdq", "3sdr", "3sdt", "3sdu", "3sdv", "4di5"...

86

[ "PUB00002995", "PUB00011119", "PUB00022455", "PUB00027530", "PUB00047335", "PUB00055208", "PUB00056585", "PUB00097281" ]

[ "9268308", "9268298", "9295272", "12432096", "17261032", "20131801", "20624401", "28841019" ]

[ "Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.", "Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expre...

[ 1997, 1997, 1997, 2002, 2007, 2010, 2010, 2017 ]

8

[]

[ "IPR034741" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 5, 23362 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 155, 124, 163 ]

3

true

Domain

Terpene synthase, metal-binding domain

Terpene_synthase_metal-bd

4

IPR005631

5,631

Flavinator of succinate dehydrogenase

SDH

Family

13,300

false

This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-...

[]

0

[ "PFAM" ]

[ "PF03937" ]

[ "Sdh5" ]

[ 13300 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9854311", "R-CEL-9854311", "R-DDI-9854311", "R-DME-9854311", "R-DRE-9854311", "R-HSA-9854311", "R-MMU-9854311", "R-RNO-9854311", "R-SCE-9854311", "R-SPO-9854311" ]

[ "REACTOME:R-BTA-9854311", "REACTOME:R-CEL-9854311", "REACTOME:R-DDI-9854311", "REACTOME:R-DME-9854311", "REACTOME:R-DRE-9854311", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-9854311", "REACTOME:R-RNO-9854311", "REACTOME:R-SCE-9854311", "REACTOME:R-SPO-9854311" ]

10

[ "1puz", "1x6i", "1x6j", "2jr5", "2lm4", "6b58", "6c12", "6vax", "8dyd" ]

9

[ "PUB00066692", "PUB00066693" ]

[ "19628817", "22474332" ]

[ "SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.", "SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria." ]

[ 2009, 2012 ]

2

[]

[ "IPR028882" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8626, 4577, 97 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 8, 1, 1, 5, 1, 11, 3, 1, 2, 7, 1, 1, 7 ]

13

true

Family

Flavinator of succinate dehydrogenase

SDH

8

IPR005632

5,632

Chaperone protein Skp

Chaperone_Skp

Family

18,216

false

The 17kDa protein Skp (also known as OmpH) of Escherichia coli is a homotrimeric periplasmic chaperone for newly synthesised outer-membrane proteins, the X-ray structure of which has been reported at resolutions of 2.35 A and 2.30 A [ , ]. Three hairpin-shaped α-helical extensions reach out by approximately 60 A from a...

[ "GO:0051082" ]

[ "unfolded protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER", "SMART" ]

[ "PF03938", "PIRSF002094", "PTHR35089", "SM00935" ]

[ "OmpH", "OMP26_Skp", "", "OmpH" ]

[ 17964, 3535, 16975, 18064 ]

4

[ "GP", "REACTOME" ]

[ "GenProp0928", "R-HSA-9760173" ]

[ "GP:GenProp0928", "REACTOME:R-HSA-9760173" ]

2

[ "1sg2", "1u2m", "4kqt", "8gl8" ]

4

[ "PUB00015159", "PUB00015160", "PUB00056898" ]

[ "15304217", "15361861", "10085039" ]

[ "Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation.", "Structure of the periplasmic chaperone Skp suggests functional similarity with cytosolic chaperones despite differing architecture.", "Characterization of the gene encoding a 26-kilodalton prot...

[ 2004, 2004, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 17782, 40, 394 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chaperone protein Skp

Chaperone_Skp

5

IPR005633

5,633

Large ribosomal subunit protein uL23, N-terminal

Ribosomal_uL23_N

Domain

6,242

false

The N-terminal domain appears to be specific to the eukaryotic large ribosomal subunit protein uL23 (also known as L25, L23, and L23a). Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the ...

[]

0

[ "PFAM" ]

[ "PF03939" ]

[ "Ribosomal_L23eN" ]

[ 6242 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-679...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-975956", "REACTOME:R-CEL-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-1799339", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72706", "REACTOME:R-DDI-975956", "REACTOME:R-DDI-97595...

44

[ "2go5", "2j37", "2ww9", "2wwa", "2wwb", "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "3jct", "4d5y", "4d67", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y"...

544

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 7, 6235 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 2, 4, 8, 4, 1, 6, 13, 1, 2, 28 ]

12

true

Domain

Large ribosomal subunit protein uL23, N-terminal

Ribosomal_uL23_N

9

IPR005634

5,634

Male specific sperm protein

MSSP

Family

24

false

This is a family of Drosophila proteins, that are typified by the repetitive motif C-G-P.

[]

0

[ "PFAM" ]

[ "PF03940" ]

[ "MSSP" ]

[ 24 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta", "Sphingomonas olei" ]

[ 23, 1 ]

2

[ "Drosophila melanogaster" ]

[ 5 ]

1

true

Family

Male specific sperm protein

MSSP

5

IPR005635

5,635

Inner centromere protein, ARK-binding domain

Inner_centromere_prot_ARK-bd

Domain

4,700

false

This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast [ ].

[]

0

[ "PFAM" ]

[ "PF03941" ]

[ "INCENP_ARK-bind" ]

[ 4700 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-4615885", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-4615885", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025", "R-XTR-141444", "R-XTR-2467813", "R-XTR-2500257", ...

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-4615885", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-4615885", "REACTOME:R-...

21

[ "2bfx", "2bfy", "2vgo", "2vgp", "2vrx", "3ztx", "4af3", "4b8l", "4b8m", "4c2v", "4c2w", "5eyk", "5k3y", "6gr8", "6gr9", "9esa", "9si3", "9si9", "9sj5", "9slj" ]

20

[ "PUB00019743" ]

[ "11950927" ]

[ "The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4700 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 15, 2, 2, 1, 1, 1, 4, 5, 1, 1, 5 ]

11

true

Domain

Inner centromere protein, ARK-binding domain

Inner_centromere_prot_ARK-bd

6

IPR005636

5,636

DTW

Domain

12,739

false

This presumed domain is found DTWD1/DTWD2 from humans and YfiP (also known as TapT) from Escherichia coli. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after. DTW domain containing protein may have a SAM-dependent acp transferase activity [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF03942", "SM01144" ]

[ "DTW", "DTW" ]

[ 12710, 12375 ]

2

[ "EC" ]

[ "2.5.1.25" ]

[ "EC:2.5.1.25" ]

1

[]

0

[ "PUB00093959" ]

[ "31863583" ]

[ "Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7042, 5658, 39 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 1, 3, 5, 1, 9, 5, 7, 11, 10 ]

10

true

Domain

DTW

7

IPR005637

5,637

TAP C-terminal (TAP-C) domain

TAP_C_dom

Domain

4,632

false

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [ ]. T...

[ "GO:0051028", "GO:0005634" ]

[ "mRNA transport", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PROFILE", "SMART", "CDD" ]

[ "PF03943", "PS51281", "SM00804", "cd14342" ]

[ "TAP_C", "TAP_C", "TAP_C", "UBA_TAP-C" ]

[ 4347, 4552, 4168, 3914 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-159227", "R-BTA-159230", "R-BTA-159231", "R-BTA-159236", "R-CEL-159236", "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-MMU-159227", "R-MMU-159230", "R-MMU-159231", "R-MMU-159236", "R-RNO-159...

[ "REACTOME:R-BTA-159227", "REACTOME:R-BTA-159230", "REACTOME:R-BTA-159231", "REACTOME:R-BTA-159236", "REACTOME:R-CEL-159236", "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-HSA-159227", "REACTOME:R-HSA-159230", "REACTOME:R-HSA-159...

25

[ "1go5", "1jkg", "1jn5", "1oai", "2jp7", "2khh", "4wp2", "6e5u", "6exz", "6iew", "6opf", "8hbn", "8hfr" ]

13

[ "PUB00008477", "PUB00013203", "PUB00018170", "PUB00024966", "PUB00026433", "PUB00043688", "PUB00048341", "PUB00071960", "PUB00071970", "PUB00079885", "PUB00079886", "PUB00079887", "PUB00079888", "PUB00079889", "PUB00079890", "PUB00079891" ]

[ "11875519", "12581645", "11073998", "11060011", "11583626", "11256625", "19401465", "9660949", "10668806", "20810649", "10567585", "11259411", "9175835", "10454577", "10323864", "10202158" ]

[ "Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1.", "Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution.", "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.", "The structu...

[ 2002, 2003, 2000, 2000, 2001, 2000, 2009, 1998, 2000, 2010, 1999, 2001, 1997, 1999, 1999, 1999 ]

16

[]

0

null

[ "Bacteria", "Eukaryota", "Sulfurisphaera ohwakuensis", "viral metagenome" ]

[ 19, 4611, 1, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 9, 4, 5, 13, 1, 12, 1, 1 ]

9

true

Domain

TAP C-terminal (TAP-C) domain

TAP_C_dom

4

IPR005639

5,639

Pesticidal crystal protein, domain I

Pest_crys_dom_I

Domain

1,584

false

This entry represents the conserved first domain of the toxic core. The crystal proteins of Bacillus thuringiensis have been extensively studied because of their pesticidal properties and their high natural levels of production [ ]. When an insect ingests these proteins, they are activated by proteolytic cleavage. The ...

[ "GO:0090729", "GO:0001907" ]

[ "toxin activity", "symbiont-mediated killing of host cell" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03945" ]

[ "Endotoxin_N" ]

[ 1584 ]

1

[]

0

[ "1ciy", "1dlc", "1i5p", "1ji6", "1w99", "2c9k", "3eb7", "3x0u", "4arx", "4ary", "4d8m", "4moa", "4qx0", "4qx1", "4qx2", "4qx3", "4w8j", "5zi1", "6dj4", "6lfp", "6ovb", "6owk", "6wpc", "7ear", "7fdp", "7qx4", "7qx5", "7qx6", "7qx7", "7qyd", "7r1e", "8hhe"...

36

[ "PUB00015089", "PUB00015090", "PUB00083810" ]

[ "7490762", "11468393", "9729610" ]

[ "Bacillus thuringiensis CryIA(a) insecticidal toxin: crystal structure and channel formation.", "Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis.", "Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins." ]

[ 1995, 2001, 1998 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)" ]

[ 1315, 268, 1 ]

3

[ "Zea mays" ]

[ 1 ]

1

true

Domain

Pesticidal crystal protein, domain I

Pest_crys_dom_I

4

IPR005641

5,641

Hexon-associated protein IX

Hexon_assoc_IX

Family

285

false

Hexon is the major coat protein in type 2 adenoviruses. Hexon forms a homo-trimer, 240 copies of which are present in the capsid, organised so that 12 lie on each of the 20 facets of this structure. The central 9 hexons in a facet are cemented together by 12 copies of protein IX [ ]. Protein IX is not necessarily requi...

[ "GO:0031423", "GO:0019028" ]

[ "hexon binding", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_04050", "PF03955" ]

[ "ADV_CAP9", "Adeno_PIX" ]

[ 232, 285 ]

2

[]

0

[ "3zif", "6b1t", "6cgv", "6yba", "6z7n", "7rd1", "7s78", "7tau", "9lr9" ]

9

[ "PUB00033894", "PUB00033895" ]

[ "8334984", "15914835" ]

[ "Difference imaging of adenovirus: bridging the resolution gap between X-ray crystallography and electron microscopy.", "The adenovirus capsid: major progress in minor proteins." ]

[ 1993, 2005 ]

2

[]

0

null

[ "Adenoviridae" ]

[ 285 ]

1

[]

0

true

Family

Hexon-associated protein IX

Hexon_assoc_IX

7

IPR005643

5,643

Jun-like transcription factor

JNK

Domain

3,330

false

The c-Jun NH(2)-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family of mitogen-activated protein (MAP) kinases [ , ].

[]

0

[ "PFAM" ]

[ "PF03957" ]

[ "Jun" ]

[ 3330 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-209394", "R-DME-209409", "R-DME-209425", "R-DME-2559580", "R-DME-2871796", "R-DME-450341", "R-DME-9018519", "R-GGA-437986", "R-HSA-1912408", "R-HSA-2173796", "R-HSA-2559580", "R-HSA-2559582", "R-HSA-2871796", "R-HSA-450341", "R-HSA-5617472", "R-HSA-5687128", "R-HSA-6785807", ...

[ "REACTOME:R-DME-209394", "REACTOME:R-DME-209409", "REACTOME:R-DME-209425", "REACTOME:R-DME-2559580", "REACTOME:R-DME-2871796", "REACTOME:R-DME-450341", "REACTOME:R-DME-9018519", "REACTOME:R-GGA-437986", "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-2173796", "REACTOME:R-HSA-2559580", "REACTOME:R-H...

32

[]

0

[ "PUB00008479", "PUB00008480" ]

[ "11402333", "11790549" ]

[ "Jun, the oncoprotein.", "The JNK signal transduction pathway." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Avian sarcoma virus (strain 17)", "Kangiella spongicola", "Metazoa" ]

[ 1, 3, 3326 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 8, 12, 7 ]

5

true

Domain

Jun-like transcription factor

JNK

4