interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR055037 | 55,037 | Short NACHT-associated C-terminal domain, family 13 | SNaCT13 | Domain | 14 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N-terminal of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22718"
] | [
"SNaCT13"
] | [
14
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
14
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain, family 13 | Short NACHT-associated C-terminal domain, family 13 | SNaCT13 | 3 |
IPR055038 | 55,038 | Short NACHT-associated C-terminal domain, family 8 | SNaCT8 | Domain | 14 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N-terminal of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22714"
] | [
"SNaCT8"
] | [
14
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteroidota"
] | [
14
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain, family 8 | Short NACHT-associated C-terminal domain, family 8 | SNaCT8 | 2 |
IPR055039 | 55,039 | Short NACHT-associated C-terminal domain, family 9 | SNaCT9 | Domain | 10 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N-terminal of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22715"
] | [
"SNaCT9"
] | [
10
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteroidota"
] | [
10
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain, family 9 | Short NACHT-associated C-terminal domain, family 9 | SNaCT9 | 5 |
IPR055040 | 55,040 | Protelomerase TelK, N-terminal domain | TelK_N | Domain | 85 | false | false | This entry represents the N-terminal domain of protelomerase TelK from Klebsiella phage phiKO2 and similar proteins from tailed bacteriophages and bacterial prophages. TelK is a hairpin telomere resolvase with DNA cleavage-rejoining activity that resolves the catenated circular dimer produced from the bidirectional rep... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22853"
] | [
"TelK_N"
] | [
85
] | 1 | [
"EC"
] | [
"3.1.22.-"
] | [
"EC:3.1.22.-"
] | 1 | [
"2v6e"
] | 1 | [
"PUB00049596"
] | [
"17889664"
] | [
"An interlocked dimer of the protelomerase TelK distorts DNA structure for the formation of hairpin telomeres."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"viral metagenome"
] | [
76,
8,
1
] | 3 | [] | [] | 0 | true | Domain | Protelomerase TelK, N-terminal domain | Protelomerase TelK, N-terminal domain | TelK_N | 7 |
IPR055041 | 55,041 | Peptidoglycan O-acetylesterase, N-terminal | Ape1_N | Domain | 534 | false | false | This domain is found at the N-terminal end of peptidoglycan O-acetylesterases Ape1 from Neisseria meningitidis and similar sequences mainly found in proteobacteria. Ape1, which occurs in bacteria that O-acetylate their peptidoglycan, has an SGNH catalytic domain ( ) at the C-terminal end. This entry represents the N-te... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22753"
] | [
"Ape1_N"
] | [
534
] | 1 | [] | [] | [] | 0 | [
"4k3u",
"4k40",
"4k7j",
"4k9s",
"8gkd",
"8gld"
] | 6 | [
"PUB00153818"
] | [
"25286847"
] | [
"Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
534
] | 1 | [] | [] | 0 | true | Domain | Peptidoglycan O-acetylesterase, N-terminal | Peptidoglycan O-acetylesterase, N-terminal | Ape1_N | 4 |
IPR055042 | 55,042 | ADP-ribosylating toxin CARDS, C-terminal beta-trefoil domain | CARDS_D3 | Domain | 8 | false | false | This domain is found at the C-terminal end of ADP-ribosylating toxin CARDS from Mycoplasma pneumoniae, the main virulence factor for this bacteria. CARDS (for Community-Acquired Respiratory Distress Syndrome Toxin) is organised into three domains, an N-terminal and tandem C-terminal β-trefoil domain. This entry represe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22346"
] | [
"CARDS_D3"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"4tlv",
"4tlw"
] | 2 | [
"PUB00153849"
] | [
"25848012"
] | [
"Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Mycoplasmoidales"
] | [
8
] | 1 | [] | [] | 0 | true | Domain | ADP-ribosylating toxin CARDS, C-terminal beta-trefoil domain | ADP-ribosylating toxin CARDS, C-terminal beta-trefoil domain | CARDS_D3 | 5 |
IPR055043 | 55,043 | CARDS D2, beta trefoil domain | CARDS-D2 | Domain | 5 | false | false | This domain is found at the C-terminal end of ADP-ribosylating toxin CARDS from Mycoplasma pneumoniae, the main virulence factor for this bacteria. CARDS (for Community-Acquired Respiratory Distress Syndrome Toxin) is organised into three domains, an N-terminal and tandem C-terminal β-trefoil domain. This entry represe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22509"
] | [
"CARDS-D2_trefoil"
] | [
5
] | 1 | [] | [] | [] | 0 | [
"4tlv",
"4tlw"
] | 2 | [
"PUB00153849"
] | [
"25848012"
] | [
"Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Mycoplasmoidales"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | CARDS D2, beta trefoil domain | CARDS D2, beta trefoil domain | CARDS-D2 | 1 |
IPR055045 | 55,045 | Turkey Adenovirus 3 Fibre protein-like, head domain | TAdV_Fibre-like_head | Domain | 18 | false | false | This entry represents the C-terminal Head Domain of the Fibre protein from Turkey Adenovirus 3, also known as turkey hemorrhagic enteritis virus (THEV) ( ) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22439"
] | [
"TAdV_Fibre-like_head"
] | [
18
] | 1 | [] | [] | [] | 0 | [
"3zpe",
"3zpf",
"4cw8",
"4d62",
"4d63"
] | 5 | [
"PUB00154254"
] | [
"26418008"
] | [
"Structure and Sialyllactose Binding of the Carboxy-Terminal Head Domain of the Fibre from a Siadenovirus, Turkey Adenovirus 3."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Siadenovirus"
] | [
18
] | 1 | [] | [] | 0 | true | Domain | Turkey Adenovirus 3 Fibre protein-like, head domain | Turkey Adenovirus 3 Fibre protein-like, head domain | TAdV_Fibre-like_head | 3 |
IPR055046 | 55,046 | Nab2-like, CCCH zinc finger | Nab2-like_Znf-CCCH | Domain | 1,026 | false | false | This entry represents the C-terminal zinc CCCH finger of Nab2-like proteins from fungi [ ]. Nab2 is a nuclear polyadenylated RNA-binding protein. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22683"
] | [
"Nab2-like_zf-CCCH_"
] | [
1026
] | 1 | [] | [] | [] | 0 | [
"4lj0"
] | 1 | [
"PUB00154096"
] | [
"24071581"
] | [
"Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1026
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Nab2-like, CCCH zinc finger | Nab2-like, CCCH zinc finger | Nab2-like_Znf-CCCH | 6 |
IPR055048 | 55,048 | Short NACHT-associated C-terminal domain 14 | SNaCT14 | Domain | 24 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22720"
] | [
"SNaCT14"
] | [
24
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
22,
2
] | 2 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 14 | Short NACHT-associated C-terminal domain 14 | SNaCT14 | 8 |
IPR055049 | 55,049 | Short NACHT-associated C-terminal domain 7 | SNaCT7 | Domain | 28 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22712"
] | [
"SNaCT7"
] | [
28
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Siphoviridae sp. ctWdm1"
] | [
27,
1
] | 2 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 7 | Short NACHT-associated C-terminal domain 7 | SNaCT7 | 5 |
IPR055050 | 55,050 | WsaF, C-terminal domain | WsaF_C | Domain | 960 | false | false | This entry represents a domain found at the C-terminal of WsaF ( ) from Geobacillus stearothermophilus and related bacterial proteins. WsaF catalyses the formation of beta-1-2-linkage of rhamnose sugars in the carbohydrate polymer. It consists of two domains, the N-terminal which binds the acceptor (the growing rhamnan... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22772"
] | [
"WsaF_C"
] | [
960
] | 1 | [] | [] | [] | 0 | [
"2x0d",
"2x0e",
"2x0f"
] | 3 | [
"PUB00054416"
] | [
"20097205"
] | [
"Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7,
913,
19,
21
] | 4 | [] | [] | 0 | true | Domain | WsaF, C-terminal domain | WsaF, C-terminal domain | WsaF_C | 5 |
IPR055051 | 55,051 | Short NACHT-associated C-terminal domain 1 | SNaCT1 | Domain | 9 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22710"
] | [
"SNaCT1"
] | [
9
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
9
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 1 | Short NACHT-associated C-terminal domain 1 | SNaCT1 | 4 |
IPR055052 | 55,052 | Short NACHT-associated C-terminal domain 6 | SNaCT6 | Domain | 3 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22713"
] | [
"SNaCT6"
] | [
3
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Paenibacillaceae"
] | [
3
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 6 | Short NACHT-associated C-terminal domain 6 | SNaCT6 | 8 |
IPR055053 | 55,053 | Short NACHT-associated C-terminal domain 11 | SNaCT11 | Domain | 11 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22716"
] | [
"SNaCT11"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
11
] | 1 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 11 | Short NACHT-associated C-terminal domain 11 | SNaCT11 | 6 |
IPR055054 | 55,054 | Short NACHT-associated C-terminal domain 10 | SNaCT10 | Domain | 57 | false | false | The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22717"
] | [
"SNaCT10"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154095"
] | [
"37160116"
] | [
"Bacterial NLR-related proteins protect against phage."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
4,
53
] | 2 | [] | [] | 0 | true | Domain | Short NACHT-associated C-terminal domain 10 | Short NACHT-associated C-terminal domain 10 | SNaCT10 | 2 |
IPR055056 | 55,056 | ArgL-like | ArgL-like | Family | 37 | false | false | This protein family includes the putative translational regulatory protein ArgL from Escherichia coli, the product of a small open reading frame (smORF), which may serve a regulatory role in the expression of its downstream gene [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22864"
] | [
"ArgL-like"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
37
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ArgL-like | ArgL-like | ArgL-like | 9 |
IPR055057 | 55,057 | PilJ-like, pilin-like domain | PilJ_N | Domain | 13 | false | false | This entry represents a N-terminal Pilin-like domain of PilJ from Clostridium difficile [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22473"
] | [
"PilJ_Pilin"
] | [
13
] | 1 | [] | [] | [] | 0 | [
"4ixj"
] | 1 | [
"PUB00069814"
] | [
"24362261"
] | [
"Structure of Clostridium difficile PilJ Exhibits Unprecedented Divergence from Known Type IV Pilins."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Clostridioides difficile"
] | [
13
] | 1 | [] | [] | 0 | true | Domain | PilJ-like, pilin-like domain | PilJ-like, pilin-like domain | PilJ_N | 7 |
IPR055058 | 55,058 | Fim1F, C-terminal domain | Fim1F_C | Domain | 5 | false | false | This domain is found at the C-terminal end of the putative fimbrium tip subunit Fim1F from Parabacteroides distasonis, which contain an N-terminal domain ( ) and a slightly larger C-terminal domain (this entry) with a transthyretin-like fold that contains seven core β-strands arranged in two β-sheets an extra conserved... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22449"
] | [
"Fim1F_C"
] | [
5
] | 1 | [] | [] | [] | 0 | [
"3r4r"
] | 1 | [
"PUB00080711"
] | [
"27062925"
] | [
"A Distinct Type of Pilus from the Human Microbiome."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Parabacteroides"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | Fim1F, C-terminal domain | Fim1F, C-terminal domain | Fim1F_C | 5 |
IPR055059 | 55,059 | RavJ, peptidase domain | RavJ_pept_dom | Domain | 9 | false | false | This entry represents the N-terminal cysteine proteinase domain of RavJ from Legionella pneumophila ( , [ ]). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22469"
] | [
"RavJ_Peptidase"
] | [
9
] | 1 | [] | [] | [] | 0 | [
"4rxv",
"4xa9"
] | 2 | [
"PUB00091363"
] | [
"27986836"
] | [
"Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Legionella"
] | [
9
] | 1 | [] | [] | 0 | true | Domain | RavJ, peptidase domain | RavJ, peptidase domain | RavJ_pept_dom | 2 |
IPR055060 | 55,060 | Acyl-CoA oxidase, C-alpha1 domain | ACOX_C_alpha1 | Domain | 18,239 | false | false | This entry represents the C-alpha1 domain from acyl-CoA oxidases which has an all-α helical structure that a forms a four α-helical bundle [ , , , , ]. This domain includes the FAD-binding and substrate-binding sites. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22924"
] | [
"ACOX_C_alpha1"
] | [
18239
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"1.3.3.6",
"PWY-5136",
"PWY-6837",
"PWY-6920",
"PWY-7007",
"PWY-7288",
"PWY-7291",
"PWY-7337",
"PWY-7338",
"PWY-7340",
"PWY-735",
"PWY-7574",
"PWY-7606",
"PWY-7726",
"PWY-7854",
"PWY-7858",
"R-BTA-2046106",
"R-BTA-390247",
"R-BTA-9033241",
"R-CEL-193368",
"R-CEL-2046106",
"... | [
"EC:1.3.3.6",
"METACYC:PWY-5136",
"METACYC:PWY-6837",
"METACYC:PWY-6920",
"METACYC:PWY-7007",
"METACYC:PWY-7288",
"METACYC:PWY-7291",
"METACYC:PWY-7337",
"METACYC:PWY-7338",
"METACYC:PWY-7340",
"METACYC:PWY-735",
"METACYC:PWY-7574",
"METACYC:PWY-7606",
"METACYC:PWY-7726",
"METACYC:PWY-78... | 53 | [
"1is2",
"1w07",
"2ddh",
"2fon",
"5k3g",
"5k3h",
"5k3i",
"5k3j",
"5y9d",
"5ys9",
"7q84",
"7q86"
] | 12 | [
"PUB00026133",
"PUB00032141",
"PUB00040761",
"PUB00153790",
"PUB00153791"
] | [
"11872165",
"15581893",
"16699197",
"27551084",
"29198706"
] | [
"Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase.",
"Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism.",
"Structure determination and analysis of acyl-CoA oxida... | [
2002,
2005,
2006,
2016,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
3588,
14627,
6,
18
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
24,
7,
9,
11,
13,
12,
8,
28,
1,
43
] | 10 | true | Domain | Acyl-CoA oxidase, C-alpha1 domain | Acyl-CoA oxidase, C-alpha1 domain | ACOX_C_alpha1 | 3 |
IPR055061 | 55,061 | Cmr1, C-terminal domain | Cmr1_C | Domain | 5 | false | false | This entry represents the C-terminal RRM domain of CRISPR system Cmr subunit Cmr1 from Archaeoglobus fulgidus [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22407"
] | [
"Cmr1_C"
] | [
5
] | 1 | [] | [] | [] | 0 | [
"4l6u"
] | 1 | [
"PUB00153874"
] | [
"24531487"
] | [
"Crystal structure and CRISPR RNA-binding site of the Cmr1 subunit of the Cmr interference complex."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | Cmr1, C-terminal domain | Cmr1, C-terminal domain | Cmr1_C | 4 |
IPR055063 | 55,063 | Small ribosomal subunit protein mS39, PPR | Rib_mS39_PPR | Repeat | 1,678 | false | false | This entry represents a pentatricopeptide repeat (PPR) section found at the N-terminal of animal Small ribosomal subunit protein mS39 (also known as PPR domain protein 3 (PTCD3)), a mitochondrial RNA-binding protein that has a role in mitochondrial translation [ , , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22330"
] | [
"Rib_mS39_PPR"
] | [
1678
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-9937383",
"R-DRE-5389840",
"R-DRE-5419276",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-DME-5389840",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-9937383",
"REACTOME:R-DRE-5389840",
"REACTOME:R-DRE-5419276",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOM... | 15 | [
"3j9m",
"3jd5",
"5aj3",
"5aj4",
"6gaw",
"6gaz",
"6neq",
"6nf8",
"6nu2",
"6nu3",
"6rw4",
"6rw5",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5i",
"7a5k",
"7l08",
"7nqh",
"7nql"... | 77 | [
"PUB00090551",
"PUB00151742",
"PUB00152699",
"PUB00154029",
"PUB00154208"
] | [
"24162847",
"24799711",
"25664731",
"25517350",
"25231995"
] | [
"Structural basis for the modular recognition of single-stranded RNA by PPR proteins.",
"Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome.",
"The design and structural characterization of a synthetic pentatricopeptide repeat protein.",
"An artificial PPR scaffold for programmable... | [
2013,
2014,
2015,
2014,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1678
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3,
5,
6
] | 6 | true | Repeat | Small ribosomal subunit protein mS39, PPR | Small ribosomal subunit protein mS39, PPR | Rib_mS39_PPR | 7 |
IPR055064 | 55,064 | BRISC complex subunit FAM175B, helical domain | BRISC_FAM175B_helical | Domain | 88 | false | false | This domain is found in BRISC complex subunit FAM175B from Camponotus floridanus and similar proteins mainly found in arthropods. This protein is an homologue of human Abraxas 2 or KIAA0157, a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the las... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22299"
] | [
"BRISC_FAM175B_helical"
] | [
88
] | 1 | [] | [] | [] | 0 | [
"5cw3",
"5cw4",
"5cw5"
] | 3 | [
"PUB00087097"
] | [
"26344097"
] | [
"Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Neoptera"
] | [
88
] | 1 | [] | [] | 0 | true | Domain | BRISC complex subunit FAM175B, helical domain | BRISC complex subunit FAM175B, helical domain | BRISC_FAM175B_helical | 2 |
IPR055065 | 55,065 | MCM10, OB-fold | OB_MCM10 | Domain | 3,746 | false | false | MCM10 is an essential eukaryotic DNA replication protein required for assembly and progression of the replication fork. This entry represents the OB fold domain from the internal domain (ID) [ ] which also contains a C3H-type zinc finger ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22379"
] | [
"OB_MCM10"
] | [
3746
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-176187",
"R-DME-68962",
"R-HSA-176187",
"R-HSA-68962",
"R-MMU-176187",
"R-MMU-68962",
"R-SCE-176187",
"R-SCE-68962",
"R-SPO-176187",
"R-SPO-68962",
"R-XTR-68962"
] | [
"REACTOME:R-DME-176187",
"REACTOME:R-DME-68962",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-68962",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-68962",
"REACTOME:R-SCE-176187",
"REACTOME:R-SCE-68962",
"REACTOME:R-SPO-176187",
"REACTOME:R-SPO-68962",
"REACTOME:R-XTR-68962"
] | 11 | [
"3ebe",
"3h15",
"7y01"
] | 3 | [
"PUB00051647",
"PUB00052999"
] | [
"19081065",
"19608746"
] | [
"Structural basis for DNA binding by replication initiator Mcm10.",
"Physical interactions between Mcm10, DNA, and DNA polymerase alpha."
] | [
2008,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lentilactobacillus parakefiri"
] | [
3745,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
2,
2,
2,
1,
2,
3,
1,
1,
4
] | 12 | true | Domain | MCM10, OB-fold | MCM10, OB-fold | OB_MCM10 | 4 |
IPR055067 | 55,067 | Alpha-amylase-like, C-terminal | AmyB-like_C | Domain | 6 | false | false | This domain is found at the C-terminal end of Alpha-amylase from Thermotoga neapolitana (AmyB), which belongs to glycoside hydrolase family 13 (GH13) and liberates maltose from multiple substrates, including starch, amylopectin and glycogen [ ]. This domain shows an all-β structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22423"
] | [
"AmyB_C"
] | [
6
] | 1 | [] | [] | [] | 0 | [
"4gkl"
] | 1 | [
"PUB00153808"
] | [
"23519419"
] | [
"Structure of a novel α-amylase AmyB from Thermotoga neapolitana that produces maltose from the nonreducing end of polysaccharides."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Thermotoga"
] | [
6
] | 1 | [] | [] | 0 | true | Domain | Alpha-amylase-like, C-terminal | Alpha-amylase-like, C-terminal | AmyB-like_C | 4 |
IPR055068 | 55,068 | Coat protein, P (projecting) domain | Coat_P | Domain | 74 | false | false | This entry represents the P (projecting) domain found at the C terminus of ssRNA positive-strand viruses coat proteins, such as that in tomato bushy stunt virus [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22402"
] | [
"Coat_P"
] | [
74
] | 1 | [] | [] | [] | 0 | [
"2tbv"
] | 1 | [
"PUB00042437"
] | [
"6481803"
] | [
"Structure of tomato bushy stunt virus. V. Coat protein sequence determination and its structural implications."
] | [
1984
] | 1 | [] | [] | 0 | 0 | null | [
"Tombusvirus"
] | [
74
] | 1 | [] | [] | 0 | true | Domain | Coat protein, P (projecting) domain | Coat protein, P (projecting) domain | Coat_P | 6 |
IPR055069 | 55,069 | Flagellar hook protein FlgE, third domain | FlgE_third | Domain | 18 | false | false | This domain is found in Flagellar hook protein FlgE from Caulobacter vibrioides and similar sequences from Caulobacter. Multiple copies of FlgE form part of the hook, a highly flexible universal joint that connects the filament to the motor of flagella. This protein consists of an N-terminal domain , followed by , then... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22367"
] | [
"FlgE_3rd"
] | [
18
] | 1 | [] | [] | [] | 0 | [
"5ay6"
] | 1 | [
"PUB00106064"
] | [
"27759043"
] | [
"Structural insights into bacterial flagellar hooks similarities and specificities."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Caulobacter"
] | [
18
] | 1 | [] | [] | 0 | true | Domain | Flagellar hook protein FlgE, third domain | Flagellar hook protein FlgE, third domain | FlgE_third | 5 |
IPR055070 | 55,070 | Epidermin leader peptide-processing serine protease EpiP, N-terminal propeptide | EpiP_N | Domain | 21 | false | false | This entry represents the propeptide domain found at the N-terminal of peptidases belonging to MEROPS family S8A, subtilisins, including Epidermin leader peptide-processing serine protease EpiP from Staphylococcus epidermidis (EpiP). This propeptide is removed by proteolytic cleavage, which activates the enzyme. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22386"
] | [
"PPI"
] | [
21
] | 1 | [] | [] | [] | 0 | [
"3qfh",
"3t41"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Staphylococcus"
] | [
21
] | 1 | [] | [] | 0 | true | Domain | Epidermin leader peptide-processing serine protease EpiP, N-terminal propeptide | Epidermin leader peptide-processing serine protease EpiP, N-terminal propeptide | EpiP_N | 4 |
IPR055071 | 55,071 | PHLPP-like, RA domain | RA_PHLPP-like | Domain | 4,161 | false | false | This entry represents the N-terminal RA domain found in the PHLPP family proteins which are are serine/threonine phosphatases that play a crucial role in the regulation of cellular signalling pathways. They are involved in the dephosphorylation of the AGC kinase family members, including AKT1, AKT2, AKT3, PRKCA, and PR... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23010"
] | [
"RA_3"
] | [
4161
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-199418",
"R-MMU-199418",
"R-RNO-199418",
"R-SCE-9696270"
] | [
"REACTOME:R-HSA-199418",
"REACTOME:R-MMU-199418",
"REACTOME:R-RNO-199418",
"REACTOME:R-SCE-9696270"
] | 4 | [] | 0 | [
"PUB00108523",
"PUB00108524",
"PUB00108525",
"PUB00108531",
"PUB00108534"
] | [
"16856944",
"15808505",
"17386267",
"21804599",
"24530606"
] | [
"RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.",
"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.",
"PHLPP and a second isoform, PHLPP2, differentially attenuate... | [
2006,
2005,
2007,
2012,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4161
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
4,
3,
4,
2,
5,
1,
1
] | 8 | true | Domain | PHLPP-like, RA domain | PHLPP-like, RA domain | RA_PHLPP-like | 8 |
IPR055072 | 55,072 | Ferlin, dsRNA-binding domain-like domain | Ferlin_DSRM | Domain | 10,328 | false | false | This entry represents a domain which structurally resembles double stranded RNA binding domains, which is found in ferlin proteins [ ]. Ferlins are involved in vesicle fusion events [ ]. Ferlins and other proteins, such as synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse togeth... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22901"
] | [
"dsrm_Ferlin"
] | [
10328
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-445355",
"R-HSA-9609523",
"R-HSA-9662360"
] | [
"REACTOME:R-HSA-445355",
"REACTOME:R-HSA-9609523",
"REACTOME:R-HSA-9662360"
] | 3 | [
"9b8k",
"9b8l",
"9h6x",
"9qe2",
"9qkv",
"9qle",
"9qlf",
"9qln",
"9qls",
"9se5",
"9sea",
"9seg",
"9sfl",
"9sh0",
"9si1"
] | 15 | [
"PUB00054013",
"PUB00071419",
"PUB00153913"
] | [
"20667140",
"21838746",
"35901179"
] | [
"Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins.",
"Ferlins: regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair.",
"Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function."
] | [
2010,
2012,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
10328
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
104,
12,
17,
26,
26
] | 6 | true | Domain | Ferlin, dsRNA-binding domain-like domain | Ferlin, dsRNA-binding domain-like domain | Ferlin_DSRM | 2 |
IPR055073 | 55,073 | NOMO-like, ninth beta-sandwich domain | NOMO1-like_9th | Domain | 3,053 | false | false | This domain is found in human BOS complex subunit NOMO1 and similar sequences, mainly from animals and plants. This domain is predicted to adopt a seven stranded β-sandwich fold. This domain is also found in Nicotinic receptor-associated protein 4 from Caenorhabditis elegans. NOMO family of proteins includes NOMO1, NOM... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22902"
] | [
"NOMO1-like_9th"
] | [
3053
] | 1 | [] | [] | [] | 0 | [
"9c7v"
] | 1 | [
"PUB00097241",
"PUB00103609"
] | [
"32820719",
"36261522"
] | [
"An ER translocon for multi-pass membrane protein biogenesis.",
"Substrate-driven assembly of a translocon for multipass membrane proteins."
] | [
2020,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
3050,
3
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
1,
4,
11,
1,
3,
3,
14
] | 9 | true | Domain | NOMO-like, ninth beta-sandwich domain | NOMO-like, ninth beta-sandwich domain | NOMO1-like_9th | 3 |
IPR055075 | 55,075 | NOMO-like, N-terminal beta-sandwich domain | NOMO-like_N | Domain | 2,915 | false | false | This domain is found at the N-terminal end of human BOS complex subunit NOMO1 and similar sequences mainly from animals and plants. This domain is predicted to adopt a seven stranded β-sandwich fold. This domain is also found in Nicotinic receptor-associated protein 4 from Caenorhabditis elegans. NOMO family of protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22898"
] | [
"NOMO1-like_1st"
] | [
2915
] | 1 | [] | [] | [] | 0 | [
"9c7v"
] | 1 | [
"PUB00097241",
"PUB00103609"
] | [
"32820719",
"36261522"
] | [
"An ER translocon for multi-pass membrane protein biogenesis.",
"Substrate-driven assembly of a translocon for multipass membrane proteins."
] | [
2020,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2915
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
1,
4,
14,
1,
1,
3,
9
] | 9 | true | Domain | NOMO-like, N-terminal beta-sandwich domain | NOMO-like, N-terminal beta-sandwich domain | NOMO-like_N | 5 |
IPR055077 | 55,077 | BRCA2, TR2 domain | BRCA2_TR2 | Domain | 902 | false | false | This domain is found near the C terminus of BRCA2 and similar proteins from vertebrates. It is likely that the TR2 domain is largely disordered and does not fold into a globular structure. It contains a highly conserved proline-rich region which is preceded by a conserved stretch of positively charged residues. This do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22687"
] | [
"BRCA2_TR2"
] | [
902
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-5685939",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693616",
"R-HSA-912446",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709275",
"R-HSA-9709570",
"R-HSA-9709603",
"R-HSA-9763198",
"R-MMU-5685939",
"R-MMU-5685942",
"R-MMU-569356... | [
"REACTOME:R-HSA-5685939",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-912446",
"REACTOME:R-HSA-9701192",
"REACTOME:R-HSA-9704331",
"REACTOME:R-HSA-9704646",
"REACTOME:R-HSA-9709275",
"REACTOME... | 24 | [
"8pbc",
"8pbd",
"8uvw"
] | 3 | [
"PUB00153835"
] | [
"17541404"
] | [
"Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
902
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
3,
4
] | 4 | true | Domain | BRCA2, TR2 domain | BRCA2, TR2 domain | BRCA2_TR2 | 8 |
IPR055079 | 55,079 | POP1, C-terminal domain | POP1_C | Domain | 3,737 | false | false | This entry represents the C-terminal domain of human Ribonuclease P/MRP protein subunit POP1 and similar proteins mainly found in animals. POP1 is a component of Ribonuclease P that cleaves the 5' leader from precursor tRNAs. The C-terminal domain of POP1 interacts with H1 RNA and has a stabilizing role. This domain ad... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22770"
] | [
"POP1_C"
] | [
3737
] | 1 | [
"EC",
"REACTOME"
] | [
"3.1.26.5",
"R-HSA-6784531"
] | [
"EC:3.1.26.5",
"REACTOME:R-HSA-6784531"
] | 2 | [
"6agb",
"6ah3",
"6ahr",
"6ahu",
"6w6v",
"7c79",
"7c7a"
] | 7 | [
"PUB00093445",
"PUB00093446"
] | [
"28115465",
"30454648"
] | [
"Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.",
"Cryo-EM Structure of the Human Ribonuclease P Holoenzyme."
] | [
2017,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Helcococcus bovis"
] | [
3736,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
2,
3,
1,
3,
6,
1,
1,
7
] | 12 | true | Domain | POP1, C-terminal domain | POP1, C-terminal domain | POP1_C | 2 |
IPR055080 | 55,080 | Gal80p-like, C-terminal domain | Gal80p-like_C | Domain | 3,238 | false | false | This domain is found in Gal80p and its homologues from fungi and bacteria. Gal80p is a yeast regulatory protein closely related to glucose-fructose oxidoreductase. In Gal80p, this domain is likely involved in the binding of Gal4p [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22685"
] | [
"Gal80p_C-like"
] | [
3238
] | 1 | [] | [] | [] | 0 | [
"2nvw",
"3bts",
"3btu",
"3btv",
"3e1k",
"3v2u"
] | 6 | [
"PUB00042055",
"PUB00050768",
"PUB00051563",
"PUB00058471",
"PUB00153958"
] | [
"17121853",
"18292341",
"18701455",
"22302941",
"30224354"
] | [
"Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p.",
"NADP regulates the yeast GAL induction system.",
"The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p.",
"The Gal3p transducer of th... | [
2007,
2008,
2008,
2012,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloferax",
"metagenomes"
] | [
1167,
2053,
3,
15
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Gal80p-like, C-terminal domain | Gal80p-like, C-terminal domain | Gal80p-like_C | 2 |
IPR055082 | 55,082 | Induced by infection | IBIN | Family | 8 | false | false | This family includes the protein product of the immunity-related lncRNA-encoded Induced by infection (IBIN) from Drosophila melanogaster ( , [ , ]). Its specific function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22859"
] | [
"IBIN"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153968",
"PUB00154874"
] | [
"36316320",
"30633769"
] | [
"Translation and natural selection of micropeptides from long non-canonical RNAs.",
"Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster."
] | [
2022,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"melanogaster group"
] | [
8
] | 1 | [
"Drosophila melanogaster"
] | [
3
] | 1 | true | Family | Induced by infection | Induced by infection | IBIN | 8 |
IPR055083 | 55,083 | Male-specific sperm protein Mst87F | Mst87F | Family | 8 | false | false | This family includes Male-specific sperm protein Mst87F from Drosophila melanogaster, the product of a transcript expressed in the germline from late pupal stages onward that overlaps with one of the enhancers of the pri transcriptional unit, which encodes the smORF-encoded peptides represented in [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22857"
] | [
"Mst87F"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154084"
] | [
"34527021"
] | [
"Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Drosophila"
] | [
8
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Male-specific sperm protein Mst87F | Male-specific sperm protein Mst87F | Mst87F | 1 |
IPR055085 | 55,085 | Major capsid protein, jelly-roll | Major_capsid_jelly-roll | Domain | 3 | false | false | This entry represents a jelly-roll domain found at the C-terminal end of the major capsid protein from Sulfolobus turreted icosahedral virus 1. The structure of this domain is similar to major capsid protein structures of the eukaryotic Paramecium bursaria Chlorella virus, and the bacteriophage PRD1, and shows a common... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22405"
] | [
"STIV-like_capsid"
] | [
3
] | 1 | [] | [] | [] | 0 | [
"2bbd",
"3j31"
] | 2 | [
"PUB00039590",
"PUB00154247"
] | [
"16357204",
"23520050"
] | [
"Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses.",
"Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography."
] | [
2005,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Alphaturrivirus",
"Sulfolobus acidocaldarius"
] | [
2,
1
] | 2 | [] | [] | 0 | true | Domain | Major capsid protein, jelly-roll | Major capsid protein, jelly-roll | Major_capsid_jelly-roll | 4 |
IPR055086 | 55,086 | Wheel complex protein P41, central domain | MG491_central | Domain | 6 | false | false | This domain is found in the organelle protein Wheel complex protein P41 (MG491) from Mycoplasma genitalium. MG491 plays a key role in the functioning, organisation and stabilisation of the terminal organelle, a protrusion of the bacterial cell membrane responsible for its flask-shaped morphology. This protein is organi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22373"
] | [
"MG491_central"
] | [
6
] | 1 | [] | [] | [] | 0 | [
"4xng"
] | 1 | [
"PUB00154063",
"PUB00163350"
] | [
"27082435",
"29470847"
] | [
"Structure-Guided Mutations in the Terminal Organelle Protein MG491 Cause Major Motility and Morphologic Alterations on Mycoplasma genitalium.",
"Cryo-electron tomography analyses of terminal organelle mutants suggest the motility mechanism of Mycoplasma genitalium."
] | [
2016,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Mycoplasmoides"
] | [
6
] | 1 | [] | [] | 0 | true | Domain | Wheel complex protein P41, central domain | Wheel complex protein P41, central domain | MG491_central | 7 |
IPR055087 | 55,087 | Gliding motility protein GldL-like, N-terminal domain | GldL-like_N | Domain | 2,418 | false | false | This entry represents a domain found N-terminal in Gliding motility protein GldL from Capnocytophaga canimorsus ( ) and similar proteins mainly found in bacteroidetes. GldL is a component of the motor complex used by the T9SS and the gliding motility apparatus to transport proteins and gliding adhesin movement at the o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22827"
] | [
"GldL_N"
] | [
2418
] | 1 | [] | [] | [] | 0 | [
"6ys8",
"7sat",
"7sau",
"7sax",
"7saz"
] | 5 | [
"PUB00153972"
] | [
"35446127"
] | [
"Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum <i>Bacteroidetes</i>."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2392,
5,
21
] | 3 | [] | [] | 0 | true | Domain | Gliding motility protein GldL-like, N-terminal domain | Gliding motility protein GldL-like, N-terminal domain | GldL-like_N | 8 |
IPR055088 | 55,088 | Fibulin, C-terminal Ig-like domain | Fibulin_C | Domain | 9,098 | false | false | This entry represents a C-terminal Ig-like domain found in fibulin proteins mainly from vertebrates. This Ig-like domain seems most closely related to the cadherin domain . Fibulins are a family of extracellular matrix glycoproteins characterised by a fibulin-type C-terminal domain preceded by tandem calcium-binding ep... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22914"
] | [
"Fibulin_C"
] | [
9098
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1566948",
"R-HSA-2129379",
"R-MMU-1566948",
"R-MMU-2129379",
"R-RNO-1566948",
"R-RNO-2129379"
] | [
"REACTOME:R-HSA-1566948",
"REACTOME:R-HSA-2129379",
"REACTOME:R-MMU-1566948",
"REACTOME:R-MMU-2129379",
"REACTOME:R-RNO-1566948",
"REACTOME:R-RNO-2129379"
] | 6 | [] | 0 | [
"PUB00011223"
] | [
"12778127"
] | [
"Fibulins: a versatile family of extracellular matrix proteins."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9098
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
25,
1,
46,
26,
35
] | 6 | true | Domain | Fibulin, C-terminal Ig-like domain | Fibulin, C-terminal Ig-like domain | Fibulin_C | 9 |
IPR055089 | 55,089 | COP9 signalosome complex subunit 3, N-terminal helical repeats | COP9_N | Domain | 4,824 | false | false | This entry represents the N-terminal domain from COP9 signalosome complex subunit 3, which consists of α-helical repeats [ , ]. COP9 is a component of the eight-subunit COP9 signalosome complex (CSN), which inactivate Cullin-RING E3 ubiquitin ligases (CRLs) by removing their covalently attached activator, NEDD8. The CS... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22788"
] | [
"COP9_hel_rpt"
] | [
4824
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5696394",
"R-BTA-6781823",
"R-BTA-8856825",
"R-BTA-8951664",
"R-CEL-5696394",
"R-CEL-6781823",
"R-CEL-8856825",
"R-CEL-8951664",
"R-DDI-5696394",
"R-DDI-6781823",
"R-DDI-8856825",
"R-DDI-8951664",
"R-DME-5696394",
"R-DME-6781823",
"R-DME-8856825",
"R-DME-8951664",
"R-DRE-88568... | [
"REACTOME:R-BTA-5696394",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8951664",
"REACTOME:R-CEL-5696394",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-8856825",
"REACTOME:R-CEL-8951664",
"REACTOME:R-DDI-5696394",
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-8856825",
"REACTOM... | 37 | [
"4d10",
"4d18",
"4wsn",
"6r6h",
"6r7f",
"6r7h",
"6r7i",
"6r7n",
"8h38",
"8h3a",
"8h3f",
"9is6"
] | 12 | [
"PUB00091374",
"PUB00151714"
] | [
"25043011",
"31444342"
] | [
"Crystal structure of the human COP9 signalosome.",
"Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome."
] | [
2014,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4824
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
2,
7,
5,
1,
2,
5,
20
] | 10 | true | Domain | COP9 signalosome complex subunit 3, N-terminal helical repeats | COP9 signalosome complex subunit 3, N-terminal helical repeats | COP9_N | 4 |
IPR055090 | 55,090 | Nucleoporin NUP120, helical domain, saccharomycetes | NUP120_helical_saccharomycetes | Domain | 75 | false | false | This domain is found in Nucleoporin NUP120 from Saccharomyces cerevisiae and similar sequences from Saccharomycetes. NUP120 is a a component of the nuclear pore complex (NPC) involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelop... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22114"
] | [
"NUP120_helical_2"
] | [
75
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SCE-159236",
"R-SCE-170822",
"R-SCE-3371453",
"R-SCE-4085377",
"R-SCE-4551638",
"R-SCE-4570464"
] | [
"REACTOME:R-SCE-159236",
"REACTOME:R-SCE-170822",
"REACTOME:R-SCE-3371453",
"REACTOME:R-SCE-4085377",
"REACTOME:R-SCE-4551638",
"REACTOME:R-SCE-4570464"
] | 6 | [
"3f7f",
"3h7n",
"3hxr",
"4xmm",
"4xmn",
"6x06",
"7n84",
"7n9f",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"8tie"
] | 14 | [
"PUB00052893",
"PUB00053083",
"PUB00154129",
"PUB00154130"
] | [
"19706512",
"19576787",
"25745173",
"33268786"
] | [
"Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.",
"The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.",
"Nuclear pores. Architecture of the nuclear pore complex coat.",
"A nanobody suite for yeast scaffold nucleoporins... | [
2009,
2009,
2015,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
75
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Nucleoporin NUP120, helical domain, saccharomycetes | Nucleoporin NUP120, helical domain, saccharomycetes | NUP120_helical_saccharomycetes | 1 |
IPR055091 | 55,091 | Carrier-protein-independent halogenase WelO5-like | WelO5-like | Family | 697 | false | false | This entry includes carrier-protein-independent halogenase WelO5 , an enzyme that chlorinates C13 of 12-epi-fischerindole U to yield 12-epi-fischerindole G. This enzymatic transformation constitutes the first step in the oxidative maturation to welwitindolinones. WelO5 adopts a cupin-like fold that is also characterist... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22814"
] | [
"WelO5"
] | [
697
] | 1 | [] | [] | [] | 0 | [
"5iqs",
"5iqt",
"5iqu",
"5iqv",
"5j4r",
"5t22",
"5trq",
"6gem",
"8acv",
"8aut"
] | 10 | [
"PUB00093050",
"PUB00095147",
"PUB00100360",
"PUB00154329"
] | [
"30867596",
"27416025",
"23554367",
"27348090"
] | [
"Discovery of a pathway for terminal-alkyne amino acid biosynthesis.",
"Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining.",
"A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pan... | [
2019,
2016,
2013,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"ecological metagenomes"
] | [
593,
82,
14,
8
] | 4 | [] | [] | 0 | true | Family | Carrier-protein-independent halogenase WelO5-like | Carrier-protein-independent halogenase WelO5-like | WelO5-like | 5 |
IPR055092 | 55,092 | Alpha-galactosidase, N-terminal | GalA_N | Domain | 42 | false | false | This domain is found at the N-terminal of Alpha-galactosidase from Thermotoga maritima (GalA), which hydrolyses the short-chain alpha-galactosaccharides raffinose, melibiose and stachyose. This GH36 enzyme is organised into three domains: an N-terminal β-sandwich fold domain (this entry), a canonical (β/α)8-fold domain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22676"
] | [
"GalA_N"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"1zy9",
"5m0x",
"5m12",
"5m16",
"5m1i",
"6gta",
"6gvd",
"6gwf",
"6gwg",
"6gx8"
] | 10 | [
"PUB00153959",
"PUB00153960"
] | [
"30104598",
"27783466"
] | [
"Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.",
"Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars."
] | [
2018,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
42
] | 1 | [] | [] | 0 | true | Domain | Alpha-galactosidase, N-terminal | Alpha-galactosidase, N-terminal | GalA_N | 5 |
IPR055093 | 55,093 | EPS8, spectrin-like domain | EPS8_2nd | Domain | 5,692 | false | false | This entry represents a spectrin-like domain is the EPS8 proteins. Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22975"
] | [
"EPS8_2nd"
] | [
5692
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9662360",
"R-HSA-9662361"
] | [
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361"
] | 2 | [] | 0 | [
"PUB00122470"
] | [
"17115031"
] | [
"Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
5692
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
76,
7,
18,
10,
16
] | 6 | true | Domain | EPS8, spectrin-like domain | EPS8, spectrin-like domain | EPS8_2nd | 6 |
IPR055094 | 55,094 | NUP210, Ig-like domain 15 | NUP210_Ig15 | Domain | 2,535 | false | false | This domain is found in Nuclear pore membrane glycoprotein 210 (NUP210) and its homologues. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22959"
] | [
"Ig_NUP210_15th"
] | [
2535
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 58 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2535
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
4,
5,
7
] | 5 | true | Domain | NUP210, Ig-like domain 15 | NUP210, Ig-like domain 15 | NUP210_Ig15 | 7 |
IPR055095 | 55,095 | NUP210, C-terminal Ig-like domain | NUP210_Ig_C | Domain | 1,808 | false | false | This domain is found at the C-terminal of Nuclear pore membrane glycoprotein 210 (NUP210) from human and its homologues. The domain represented by this entry is one of these constituent Ig-like domain and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22957"
] | [
"NUP210_Ig"
] | [
1808
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 58 | [
"7r5j",
"7r5k"
] | 2 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1808
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
5,
7
] | 5 | true | Domain | NUP210, C-terminal Ig-like domain | NUP210, C-terminal Ig-like domain | NUP210_Ig_C | 7 |
IPR055096 | 55,096 | NUP210, Ig-like domain 1 | Ig_NUP210_1st | Domain | 2,747 | false | false | This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and its homologues. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spaci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22967"
] | [
"Ig_NUP210_1st"
] | [
2747
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2747
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
1,
2,
5,
2,
7,
4
] | 9 | true | Domain | NUP210, Ig-like domain 1 | NUP210, Ig-like domain 1 | Ig_NUP210_1st | 8 |
IPR055097 | 55,097 | NUP210, Ig-like domain 2 | Ig_NUP210_2nd | Domain | 3,258 | false | false | This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and its homologues. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spaci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22969"
] | [
"Ig_NUP210_2nd"
] | [
3258
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3258
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
1,
2,
5,
1,
7,
4
] | 9 | true | Domain | NUP210, Ig-like domain 2 | NUP210, Ig-like domain 2 | Ig_NUP210_2nd | 1 |
IPR055098 | 55,098 | NUP210, Ig-like domain 3 | Ig_NUP210_3rd | Domain | 2,544 | false | false | This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and its homologues. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spaci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22963"
] | [
"Ig_NUP210_3rd"
] | [
2544
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2544
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
2,
5,
7
] | 6 | true | Domain | NUP210, Ig-like domain 3 | NUP210, Ig-like domain 3 | Ig_NUP210_3rd | 1 |
IPR055099 | 55,099 | NUP210, Ig-like domain 7 | Ig_NUP210_7th | Domain | 2,966 | false | false | This domain is found in Nuclear pore membrane glycoprotein 210 (NUP210) and its homologues. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22962"
] | [
"Ig_NUP210_7th"
] | [
2966
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2966
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
2,
1,
2,
4,
1,
7,
9
] | 9 | true | Domain | NUP210, Ig-like domain 7 | NUP210, Ig-like domain 7 | Ig_NUP210_7th | 1 |
IPR055100 | 55,100 | LYC1, C-terminal domain | GNAT_LYC1-like | Domain | 2,436 | false | false | This domain is found C-terminal in Lysine acetyltransferase (LYC1) and other related fungal proteins. LYC1 catalyses the first step the lysine degradation pathway. The domain represented by this entry is predicted to adopt GNAT-like fold. It is found usually upstream Acetyltransferase GNAT domain ( ) suggesting a possi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22998"
] | [
"GNAT_LYC1-like"
] | [
2436
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153984"
] | [
"8082161"
] | [
"LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Cystobacterineae",
"Eukaryota"
] | [
40,
2396
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1
] | 2 | true | Domain | LYC1, C-terminal domain | LYC1, C-terminal domain | GNAT_LYC1-like | 6 |
IPR055101 | 55,101 | Abortive infection phage resistance protein, N-terminal domain | AIPR_N | Domain | 1,072 | false | false | This entry represents the N-terminal domain found in an abortive infection phage resistance protein often found in restriction modification system operons [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22879"
] | [
"AIPR_N"
] | [
1072
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044141"
] | [
"18346280"
] | [
"MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomicrobia",
"unclassified sequences"
] | [
1052,
9,
11
] | 3 | [] | [] | 0 | true | Domain | Abortive infection phage resistance protein, N-terminal domain | Abortive infection phage resistance protein, N-terminal domain | AIPR_N | 9 |
IPR055102 | 55,102 | PDXDC1-like, third domain | PDXDC1-like_3rd | Domain | 2,308 | false | false | This entry represents a domain found towards the C-terminal of Pyridoxal-dependent decarboxylase domain-containing protein 1 (PDXDC1). PDXDC1 has been associated with the modulation of prepulse inhibition of acoustic startle, perhaps through the metabolism of catecholamine neurotransmitters [ ]. The function of this do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22937"
] | [
"PDXDC1-like_cen2"
] | [
2308
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"4.1.1.-",
"PWY-3385",
"PWY-3542",
"PWY-5113",
"PWY-5163",
"PWY-5706",
"PWY-5826",
"PWY-5870",
"PWY-5871",
"PWY-5872",
"PWY-5873",
"PWY-5956",
"PWY-6055",
"PWY-6262",
"PWY-6309",
"PWY-6322",
"PWY-6340",
"PWY-6627",
"PWY-6633",
"PWY-6935",
"PWY-6959",
"PWY-7007",
"PWY-7154... | [
"EC:4.1.1.-",
"METACYC:PWY-3385",
"METACYC:PWY-3542",
"METACYC:PWY-5113",
"METACYC:PWY-5163",
"METACYC:PWY-5706",
"METACYC:PWY-5826",
"METACYC:PWY-5870",
"METACYC:PWY-5871",
"METACYC:PWY-5872",
"METACYC:PWY-5873",
"METACYC:PWY-5956",
"METACYC:PWY-6055",
"METACYC:PWY-6262",
"METACYC:PWY-6... | 43 | [] | 0 | [
"PUB00154156"
] | [
"28485732"
] | [
"Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavobacteriaceae"
] | [
2306,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
13,
1,
3,
2,
8
] | 6 | true | Domain | PDXDC1-like, third domain | PDXDC1-like, third domain | PDXDC1-like_3rd | 6 |
IPR055103 | 55,103 | PDXDC1/PDXD2, second domain | PDXDC1-like_2nd | Domain | 2,284 | false | false | This entry represents the second domain found in the central region of Pyridoxal-dependent decarboxylase domain-containing protein 1 (PDXDC1) and at the C-terminal of PDXD2. PDXDC1 has been associated with the modulation of prepulse inhibition of acoustic startle, perhaps through the metabolism of catecholamine neurotr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22930"
] | [
"PDXDC1-like_cen"
] | [
2284
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"4.1.1.-",
"PWY-3385",
"PWY-3542",
"PWY-5113",
"PWY-5163",
"PWY-5706",
"PWY-5826",
"PWY-5870",
"PWY-5871",
"PWY-5872",
"PWY-5873",
"PWY-5956",
"PWY-6055",
"PWY-6262",
"PWY-6309",
"PWY-6322",
"PWY-6340",
"PWY-6627",
"PWY-6633",
"PWY-6935",
"PWY-6959",
"PWY-7007",
"PWY-7154... | [
"EC:4.1.1.-",
"METACYC:PWY-3385",
"METACYC:PWY-3542",
"METACYC:PWY-5113",
"METACYC:PWY-5163",
"METACYC:PWY-5706",
"METACYC:PWY-5826",
"METACYC:PWY-5870",
"METACYC:PWY-5871",
"METACYC:PWY-5872",
"METACYC:PWY-5873",
"METACYC:PWY-5956",
"METACYC:PWY-6055",
"METACYC:PWY-6262",
"METACYC:PWY-6... | 43 | [] | 0 | [
"PUB00154156"
] | [
"28485732"
] | [
"Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2284
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
13,
1,
9,
2,
10
] | 6 | true | Domain | PDXDC1/PDXD2, second domain | PDXDC1/PDXD2, second domain | PDXDC1-like_2nd | 2 |
IPR055104 | 55,104 | CCR4-NOT transcription complex subunit 1, N-terminal domain | CNOT1_1st | Domain | 2,122 | false | false | This domain is found at the N-terminal of human CCR4-NOT transcription complex subunit 1 (CNOT1) and similar sequences from animals. CNOT1 is a scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22940"
] | [
"CNOT1_1st"
] | [
2122
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-6804115",
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115",
"R-XTR-429947",
"R-XTR-6804115"
] | [
"REACTOME:R-DRE-6804115",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115",
"REACTOME:R-XTR-429947",
"REACTOME:R-XTR-6804115"
] | 8 | [
"8bfi",
"8fy3",
"8fy4"
] | 3 | [
"PUB00153875"
] | [
"36586408"
] | [
"The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2122
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2,
6,
5
] | 5 | true | Domain | CCR4-NOT transcription complex subunit 1, N-terminal domain | CCR4-NOT transcription complex subunit 1, N-terminal domain | CNOT1_1st | 6 |
IPR055106 | 55,106 | ELFN1/ELFN2, fibronectin type-III domain | ELFN_Fn3 | Domain | 2,004 | false | false | This domain is found in human ELFN1 and ELFN2 proteins and its homologues. The postsynaptic ELFN1 regulates target-specific presynaptic properties which influences the timing of recruitment of inhibitory neuron subtypes [ ]. Both ELFN1 and ELFN2 inhibit the phosphatase activity of protein phosphatase 1 (PP1) complexes ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22986"
] | [
"Fn3_ELFN"
] | [
2004
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060082",
"PUB00153925"
] | [
"19389623",
"23042292"
] | [
"Docking motif-guided mapping of the interactome of protein phosphatase-1.",
"Elfn1 regulates target-specific release probability at CA1-interneuron synapses."
] | [
2009,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2004
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2,
4
] | 4 | true | Domain | ELFN1/ELFN2, fibronectin type-III domain | ELFN1/ELFN2, fibronectin type-III domain | ELFN_Fn3 | 9 |
IPR055107 | 55,107 | Mediator of RNA polymerase II transcription subunit 14, RM8 | Med14_RM8 | Domain | 1,885 | false | false | This entry represents an α/β domain that is found tandemly repeated in human Mediator of RNA polymerase II transcription subunit 14 (Med14) and its homologues. This entry represents repeat RM8. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22983"
] | [
"RM8_Med14"
] | [
1885
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 14 | [
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"16595664",
"33958484",
"31402173"
] | [
"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.",
"Structures of the human Mediator and Mediator-bound preinitiation complex.",
"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote... | [
2006,
2021,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1885
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
3,
2,
6
] | 5 | true | Domain | Mediator of RNA polymerase II transcription subunit 14, RM8 | Mediator of RNA polymerase II transcription subunit 14, RM8 | Med14_RM8 | 5 |
IPR055108 | 55,108 | Syntrophin, C-terminal PH domain | Syntrophin_4th | Domain | 5,648 | false | false | This entry represents the C-terminal PH domain found in syntrophin proteins. The syntrophin family are intracellular membrane-associated proteins that interact with both ion channels and signalling proteins. As such, syntrophins appear to be important for linking ion channels to intracellular signalling pathways. Syntr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23012"
] | [
"Syntrophin_4th"
] | [
5648
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9913351",
"R-CEL-9913351",
"R-HSA-9913351",
"R-MMU-9913351"
] | [
"REACTOME:R-BTA-9913351",
"REACTOME:R-CEL-9913351",
"REACTOME:R-HSA-9913351",
"REACTOME:R-MMU-9913351"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
5648
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
11,
13,
13,
16
] | 6 | true | Domain | Syntrophin, C-terminal PH domain | Syntrophin, C-terminal PH domain | Syntrophin_4th | 9 |
IPR055109 | 55,109 | SMCHD1, ribosomal S5 domain 2-like domain | SMCHD1_S5 | Domain | 1,171 | false | false | This domain is found in human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) protein and its homologues. SMCHD1 is an epigenetic repressor that may participate in structural manipulation of chromatin in an ATP-dependent manner as a part of its role in gene expression regulatio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22899"
] | [
"SMCHD1_S5"
] | [
1171
] | 1 | [] | [] | [] | 0 | [
"6mw7"
] | 1 | [
"PUB00112366",
"PUB00154237",
"PUB00161615",
"PUB00161616",
"PUB00161617"
] | [
"25294876",
"31312724",
"23542155",
"24790221",
"29748383"
] | [
"Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.",
"A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1.",
"Human inactive X chromosome... | [
2014,
2019,
2013,
2014,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1171
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
4
] | 4 | true | Domain | SMCHD1, ribosomal S5 domain 2-like domain | SMCHD1, ribosomal S5 domain 2-like domain | SMCHD1_S5 | 1 |
IPR055110 | 55,110 | Reversion-inducing cysteine-rich with Kazal motifs, N-terminal | RECK-like_N | Domain | 1,577 | false | false | This domain is found at the N-terminal of human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and similar proteins mainly found in vertebrates. RECK is a membrane-anchored glycoprotein that plays a role in Wnt7-specific responses in the central nervous system angiogenesis and in the blood-brain barr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22961"
] | [
"RECK-like_N"
] | [
1577
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 3 | [
"8tzp"
] | 1 | [
"PUB00154871"
] | [
"37852257"
] | [
"Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1577
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
4,
2,
6
] | 5 | true | Domain | Reversion-inducing cysteine-rich with Kazal motifs, N-terminal | Reversion-inducing cysteine-rich with Kazal motifs, N-terminal | RECK-like_N | 2 |
IPR055111 | 55,111 | RNF34/RFFL, HeH domain | RNF34_RFFL_HeH | Domain | 4,022 | false | false | This entry represents a domain found in human E3 ubiquitin-protein ligase rififylin (RNF34L), RFFL and similar eukaryotic proteins. This domain is predicted to adopt an helix-extended loop-helix (HeH) structure. RNF34 and RFFL are of E3 ubiquitin-protein ligases that play a crucial role in various biological processes ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22968"
] | [
"RNF34L-like_3rd"
] | [
4022
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-6804757",
"R-BTA-983168",
"R-HSA-6804757",
"R-HSA-983168",
"R-MMU-6804757",
"R-MMU-983168",
"R-RNO-6804757",
"R-RNO-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-6804757",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-6804757",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-6804757",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-6804757",
"REACTOME:R-RNO-983168"
] | 10 | [] | 0 | [
"PUB00133983",
"PUB00133985",
"PUB00133991",
"PUB00135934",
"PUB00135935",
"PUB00154873"
] | [
"15069192",
"22064484",
"18382127",
"18450452",
"17121812",
"25012219"
] | [
"Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.",
"RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism.",
"CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing M... | [
2004,
2012,
2008,
2008,
2007,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4022
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
3,
6,
6,
13
] | 5 | true | Domain | RNF34/RFFL, HeH domain | RNF34/RFFL, HeH domain | RNF34_RFFL_HeH | 8 |
IPR055112 | 55,112 | Cmr7b-like, BtrG-like domain | Cmr7b-like | Domain | 5 | false | false | This entry represents a BtrG-like domain present in Cmr7b protein from Sulfolobus solfataricus. Cmr7b is involved in the CRISPR/Cas pathway [ ]. CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22392"
] | [
"Cmr7b-like"
] | [
5
] | 1 | [] | [] | [] | 0 | [
"2xvo"
] | 1 | [
"PUB00094641"
] | [
"22227115"
] | [
"Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | Cmr7b-like, BtrG-like domain | Cmr7b-like, BtrG-like domain | Cmr7b-like | 1 |
IPR055113 | 55,113 | Mediator of RNA polymerase II transcription subunit 14, RM2 | Med14_RM2 | Domain | 1,982 | false | false | This entry represents an α/β domain that is found tandemly repeated in human Mediator of RNA polymerase II transcription subunit 14 (Med14) and its homologues. This entry represents repeat RM2. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22981"
] | [
"RM2_Med14"
] | [
1982
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 14 | [
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"16595664",
"33958484",
"31402173"
] | [
"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.",
"Structures of the human Mediator and Mediator-bound preinitiation complex.",
"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote... | [
2006,
2021,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1982
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
2,
2,
7
] | 6 | true | Domain | Mediator of RNA polymerase II transcription subunit 14, RM2 | Mediator of RNA polymerase II transcription subunit 14, RM2 | Med14_RM2 | 3 |
IPR055114 | 55,114 | Mediator of RNA polymerase II transcription subunit 14, RM6 | Med14_RM6 | Domain | 2,006 | false | false | This entry represents an α/β domain that is found tandemly repeated in the homologues of human Mediator of RNA polymerase II transcription subunit 14 (Med14). This entry represents repeat RM6. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymeras... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22984"
] | [
"RM6_Med14"
] | [
2006
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 14 | [
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"16595664",
"33958484",
"31402173"
] | [
"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.",
"Structures of the human Mediator and Mediator-bound preinitiation complex.",
"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote... | [
2006,
2021,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2006
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
2,
6
] | 5 | true | Domain | Mediator of RNA polymerase II transcription subunit 14, RM6 | Mediator of RNA polymerase II transcription subunit 14, RM6 | Med14_RM6 | 5 |
IPR055116 | 55,116 | DBF4, BRCT domain | DBF4_BRCT | Domain | 1,447 | false | false | This entry represents the BRCT domain found in DBF4 from S.cerevisiae, its orthologues from S.pombe and similar sequences from fungi. DBF4 is a conserved eukaryotic protein that functions as the regulatory subunit of the Dbf4-dependent kinase (DDK) complex. DDK plays essential roles in DNA replication initiation and ch... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22437"
] | [
"DBF4_BRCT"
] | [
1447
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SCE-176187",
"R-SCE-68962",
"R-SPO-176187",
"R-SPO-68962"
] | [
"REACTOME:R-SCE-176187",
"REACTOME:R-SCE-68962",
"REACTOME:R-SPO-176187",
"REACTOME:R-SPO-68962"
] | 4 | [
"3oq0",
"3oq4",
"3qbz",
"5t2f",
"5t2s",
"7p5z",
"7pt6",
"7pt7",
"7v3v"
] | 9 | [
"PUB00109982",
"PUB00133281"
] | [
"27681475",
"22130670"
] | [
"'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.",
"Saccharomyces cerevisiae Dbf4 has unique fold necessary for interaction with Rad53 kinase."
] | [
2016,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1447
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2
] | 3 | true | Domain | DBF4, BRCT domain | DBF4, BRCT domain | DBF4_BRCT | 5 |
IPR055117 | 55,117 | MINAR1, N-terminal helical domain | MINAR1_N | Domain | 1,064 | false | false | This entry represents a N-terminal conserved domain found in the Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) family. MINAR1 is a Notch2-binding protein that has been shown to inhibit angiogenesis and breast cancer growth [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22948"
] | [
"MINAR1_N"
] | [
1064
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089813"
] | [
"29329397"
] | [
"MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1064
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2,
3
] | 4 | true | Domain | MINAR1, N-terminal helical domain | MINAR1, N-terminal helical domain | MINAR1_N | 9 |
IPR055118 | 55,118 | Fatty acid synthase-like, central AT domain | FAS-like_AT_central | Domain | 1,246 | false | false | This entry includes a domain found in the central region of the acyltransferase domain (AT) from fungal type I fatty acid synthase (FAS) mainly from myco and bifidobacteria, which have secondary-structure elements and sequence homology [ , , , , ]. Mycobacterial fatty acid synthase (FAS) complex is an homohexameric mul... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22690"
] | [
"FAS_AT_central"
] | [
1246
] | 1 | [] | [] | [] | 0 | [
"4v8l",
"4v8v",
"4v8w",
"6gjc"
] | 4 | [
"PUB00042363",
"PUB00049478",
"PUB00091619",
"PUB00153935",
"PUB00153936",
"PUB00153938"
] | [
"17448991",
"17431182",
"23291528",
"31506493",
"32471977",
"31509190"
] | [
"The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.",
"Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase.",
"7.5-A cryo-em structure of the mycobacterial fatty acid synthase.",
"Electron cryomicroscopy... | [
2007,
2007,
2013,
2019,
2020,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Tuber borchii",
"uncultured organism"
] | [
1244,
1,
1
] | 3 | [] | [] | 0 | true | Domain | Fatty acid synthase-like, central AT domain | Fatty acid synthase-like, central AT domain | FAS-like_AT_central | 4 |
IPR055119 | 55,119 | Abnormal cell migration protein 18-like, fibronectin type I domain | Mig18_Fn1 | Domain | 1,190 | false | false | This entry represents a domain that structurally resembles the fibronectin type 1 repeat. This domain is found in Abnormal cell migration protein 18 (Mig-18) from Caenorhabditis elegans and other uncharacterised nematode proteins. Mig-18 is required for the directional control of distal tip cell migration during gonado... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23003"
] | [
"Fn1_2"
] | [
1190
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090791",
"PUB00154872"
] | [
"24318535",
"10388818"
] | [
"The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.",
"Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans."
] | [
2014,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1190
] | 1 | [
"Caenorhabditis elegans"
] | [
12
] | 1 | true | Domain | Abnormal cell migration protein 18-like, fibronectin type I domain | Abnormal cell migration protein 18-like, fibronectin type I domain | Mig18_Fn1 | 1 |
IPR055120 | 55,120 | Chitin synthase chs-1/2, N-terminal putative transporter domain | Chs-1/2_IV_N | Domain | 1,642 | false | false | This entry represents an N-terminal integral membrane domain found in chitin synthases chs-1/2 from C.elegans [ ] and similar sequences mainly from arthropods, nematodes and molluscs. The Chitin Synthase Class IV family is involved in the synthesis of chitin, which is a key structural component in various biological st... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23000"
] | [
"ChitinSynthase_IV_N"
] | [
1642
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096621",
"PUB00096622"
] | [
"16098962",
"20971008"
] | [
"The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.",
"Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Cotesia sesamiae Mombasa bracovirus"
] | [
1641,
1
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
3,
5
] | 2 | true | Domain | Chitin synthase chs-1/2, N-terminal putative transporter domain | Chitin synthase chs-1/2, N-terminal putative transporter domain | Chs-1/2_IV_N | 7 |
IPR055121 | 55,121 | Winged helix-turn-helix domain, arthropods/nematodes | HTH_69 | Domain | 912 | false | false | This entry represents a winged helix-turn-helix domain that may bind to DNA, mainly found in uncharacterised sequences from arthropods and nematodes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22979"
] | [
"HTH_69"
] | [
912
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Stenosarchaea group"
] | [
907,
5
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
4,
3
] | 2 | true | Domain | Winged helix-turn-helix domain, arthropods/nematodes | Winged helix-turn-helix domain, arthropods/nematodes | HTH_69 | 9 |
IPR055122 | 55,122 | Mediator complex subunit MED14, N-terminal | Med14_N | Domain | 5,104 | false | false | This entry represents the N-terminal domain found human Mediator of RNA polymerase II transcription subunit 14 (Med14) and its homologues. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08638"
] | [
"Med14"
] | [
5104
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"5n9j",
"5oqm",
"5u0p",
"5u0s",
"6w1s",
"6xp5",
"7emf",
"7ena",
"7enc",
"7enj",
"7jmn",
"7lbm",
"7nvr",
"7ui9",
"7uic",
"7uif",
"7uig",
"7uil",
"7uio",
"8cen",
"8ceo",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 28 | [
"PUB00033293",
"PUB00033294",
"PUB00033372",
"PUB00050849",
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"7851756",
"7635307",
"15175151",
"18381891",
"16595664",
"33958484",
"31402173"
] | [
"Requirement for RGR1 and SIN4 in RME1-dependent repression in Saccharomyces cerevisiae.",
"Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation.",
"A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulat... | [
1994,
1995,
2004,
2008,
2006,
2021,
2019
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5104
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
3,
2,
3,
2,
1,
4,
6,
1,
1,
13
] | 12 | true | Domain | Mediator complex subunit MED14, N-terminal | Mediator complex subunit MED14, N-terminal | Med14_N | 6 |
IPR055123 | 55,123 | Polyketide synthase extender module SpnB-like, Rossmann fold domain | SpnB-like_Rossmann | Domain | 17,653 | false | false | This entry represents a domain found in a group of proteins mainly from actinomycetes, including the polyketide synthase extender module SpnB from Saccharopolyspora spinosa ( ) and Phenolphthiocerol synthesis polyketide synthase type I Pks15/1 from Mycobacterium bovis [ ]. This domain adopts a classical Rossmann fold [... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22953"
] | [
"SpnB_Rossmann"
] | [
17653
] | 1 | [
"EC"
] | [
"2.3.1"
] | [
"EC:2.3.1"
] | 1 | [
"2fr0",
"2fr1",
"3mjc",
"3mje",
"3mjs",
"3mjt",
"3mjv",
"3qp9",
"3slk",
"4dif",
"4hxy",
"4imp",
"4l4x",
"5xwv",
"5xww",
"6w7s",
"6wh9",
"7m7e",
"7m7f",
"7m7g",
"7m7h",
"7m7i",
"7m7j",
"7s6b",
"7s6c",
"7s6d",
"8g7w",
"8tjn",
"8tjo",
"9pat",
"9pav",
"9pc6"... | 32 | [
"PUB00059434",
"PUB00154945"
] | [
"22634636",
"12138124"
] | [
"Divergence of multimodular polyketide synthases revealed by a didomain structure.",
"Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglyco... | [
2012,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
17214,
431,
8
] | 3 | [] | [] | 0 | true | Domain | Polyketide synthase extender module SpnB-like, Rossmann fold domain | Polyketide synthase extender module SpnB-like, Rossmann fold domain | SpnB-like_Rossmann | 4 |
IPR055124 | 55,124 | ATP-dependent RNA helicase DDX60, PIN-like domain | PIN-like_DDX60 | Domain | 2,109 | false | false | This domain is found N-terminal in human ATP-dependent RNA helicase DDX60 (also known as DEAD-box RNA helicase) and similar sequences from animals and fungi. This domain adopts a globular structure with a significant structural similarity to PIN domains. DDX60 binds ssRNA, dsRNA and dsDNA and can promote the binding of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23002"
] | [
"PIN-like_DDX60"
] | [
2109
] | 1 | [] | [] | [] | 0 | [
"7ase",
"7ask"
] | 2 | [
"PUB00140287",
"PUB00154169"
] | [
"21791617",
"33357443"
] | [
"DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.",
"Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts."
] | [
2011,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2109
] | 1 | [
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
11,
6,
2,
6,
1
] | 6 | true | Domain | ATP-dependent RNA helicase DDX60, PIN-like domain | ATP-dependent RNA helicase DDX60, PIN-like domain | PIN-like_DDX60 | 1 |
IPR055125 | 55,125 | Wiz, C-terminal zinc finger | Wiz_C_Znf | Domain | 2,850 | false | false | This entry represents a C2H2 type zinc finger found at the C-terminal end of human Protein Wiz and similar sequences from vertebrates. Wiz interacts with the a SET-domain histone methyltransferases G9a and GLP independently and plays a major role in G9a/GLP heterodimer formation and stabilisation [ ]. This domain is al... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23015"
] | [
"zf-WIZ"
] | [
2850
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088114",
"PUB00154880"
] | [
"16702210",
"25789554"
] | [
"Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.",
"The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression."
] | [
2006,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
2850
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
13,
9,
13
] | 4 | true | Domain | Wiz, C-terminal zinc finger | Wiz, C-terminal zinc finger | Wiz_C_Znf | 5 |
IPR055126 | 55,126 | Enhanced disease resistance 4-like, N-terminal domain | EDR4-like_N | Domain | 2,168 | false | false | This domain is found at the N-terminal end of Protein Enhanced disease resistance 4 from Arabidopsis thaliana (EDR4), which plays a negative role in salicylic acid (SA)-mediated resistance to powdery mildew [ ], and similar plant proteins. This domain is predicted to adopt an all-β structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22910"
] | [
"EDR4-like_1st"
] | [
2168
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090747"
] | [
"25747881"
] | [
"ENHANCED DISEASE RESISTANCE4 associates with CLATHRIN HEAVY CHAIN2 and modulates plant immunity by regulating relocation of EDR1 in Arabidopsis."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2168
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
19,
25
] | 3 | true | Domain | Enhanced disease resistance 4-like, N-terminal domain | Enhanced disease resistance 4-like, N-terminal domain | EDR4-like_N | 7 |
IPR055127 | 55,127 | YEATS domain-containing protein 2, three-helical bundle domain | YEATS2_3HBD | Domain | 1,755 | false | false | This domain is found in human YEATS domain-containing protein 2 (YEATS2) and related proteins from animals and fungi. YEATS2 is a chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 [ , , ]. It specifically recognises and binds histone H3 crotonylated ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22951"
] | [
"3HBD"
] | [
1755
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-9772755",
"R-MMU-9772755"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-9772755"
] | 3 | [] | 0 | [
"PUB00053704",
"PUB00084335",
"PUB00142626"
] | [
"19103755",
"18838386",
"27103431"
] | [
"The double-histone-acetyltransferase complex ATAC is essential for mammalian development.",
"Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.",
"YEATS2 is a selective histone crotonylation reader."
] | [
2009,
2008,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Cotesia sesamiae Mombasa bracovirus",
"Eukaryota"
] | [
1,
1754
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
1,
3,
3
] | 5 | true | Domain | YEATS domain-containing protein 2, three-helical bundle domain | YEATS domain-containing protein 2, three-helical bundle domain | YEATS2_3HBD | 6 |
IPR055128 | 55,128 | Carbamoyltransferase, Kae1-like domain, second subdomain | HypF_C_2 | Domain | 8,086 | false | false | This domain is found at the C-terminal of Carbamoyltransferase from Caldanaerobacter subterraneus (HypF, ) and similar prokaryotic sequences. HypF is involved in the biosynthesis of the nitrile group as a precursor of the cyano groups of hydrogenases. HypF consists of four domains: the acylphosphatase domain ( ), the Z... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22521"
] | [
"HypF_C_2"
] | [
8086
] | 1 | [] | [] | [] | 0 | [
"3tsp",
"3tsq",
"3tsu",
"3ttc",
"3ttd",
"3ttf",
"3vth",
"3vti",
"4g9i"
] | 9 | [
"PUB00047751",
"PUB00048273",
"PUB00059031",
"PUB00059772",
"PUB00091577"
] | [
"17766251",
"18951093",
"22153500",
"19172740",
"22740694"
] | [
"An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro.",
"Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.",
"Structure of hydrogenase maturation pro... | [
2007,
2008,
2011,
2008,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
406,
7502,
10,
168
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Carbamoyltransferase, Kae1-like domain, second subdomain | Carbamoyltransferase, Kae1-like domain, second subdomain | HypF_C_2 | 6 |
IPR055130 | 55,130 | Presequence protease, mitochondrial-type, C-terminal domain | PreP_C | Domain | 7,457 | false | false | Human presequence protease, mitochondrial (PreP) is a protease that degrades targeting peptides as well as other unstructured peptides in mitochondria [ , , , , ]. This entry represents the C-terminal domain of PreP and similar proteins from eukaryotes and bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22516"
] | [
"PreP_C"
] | [
7457
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.24.-",
"PWY-8119",
"R-DME-1268020",
"R-DRE-1268020",
"R-HSA-1268020",
"R-MMU-1268020",
"R-SPO-1268020",
"R-XTR-1268020"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119",
"REACTOME:R-DME-1268020",
"REACTOME:R-DRE-1268020",
"REACTOME:R-HSA-1268020",
"REACTOME:R-MMU-1268020",
"REACTOME:R-SPO-1268020",
"REACTOME:R-XTR-1268020"
] | 8 | [
"2fge",
"3s5h",
"3s5i",
"3s5k",
"3s5m",
"4l3t",
"4nge",
"4rpu",
"6xos",
"6xot",
"6xou",
"6xov",
"6xow",
"7di7",
"7dia",
"7dij",
"7vpe",
"8ho4",
"8ho5",
"8wxw",
"8wxz",
"8wyt",
"8wyu",
"8wyx",
"8wyy"
] | 25 | [
"PUB00154180",
"PUB00154181",
"PUB00154882",
"PUB00154883",
"PUB00154884"
] | [
"24931469",
"35383169",
"19196155",
"29764912",
"29383861"
] | [
"Molecular basis of substrate recognition and degradation by human presequence protease.",
"Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.",
"Mammalian pitrilysin: substrate specificity and mitochondrial targeting.",
"Mitochondrial <i>PITRM1<... | [
2014,
2022,
2009,
2018,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Podoviridae sp. ctAmM4",
"unclassified sequences"
] | [
2779,
4630,
1,
47
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Ze... | [
14,
2,
2,
11,
1,
1,
3,
5,
1,
3
] | 10 | true | Domain | Presequence protease, mitochondrial-type, C-terminal domain | Presequence protease, mitochondrial-type, C-terminal domain | PreP_C | 7 |
IPR055132 | 55,132 | Ribonuclease J, beta-CASP domain | RNase_J_b_CASP | Domain | 22,640 | false | false | This domain is found in Ribonuclease J from Thermus thermophilus (RNaseJ) and similar prokaryotic proteins [ , , ]. RNaseJ is an RNase that has endonuclease and possibly 5'-3' exonuclease activity. It is probably involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. This protein shows ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22505"
] | [
"RNase_J_b_CASP"
] | [
22640
] | 1 | [] | [] | [] | 0 | [
"3bk1",
"3bk2",
"3t3n",
"3t3o",
"3zq4",
"4xwt",
"4xww",
"5a0t",
"5a0v",
"5haa",
"5hab",
"5ws2",
"6k6s",
"6k6w",
"6llb",
"7pcr",
"7wnt",
"7wnu",
"8cgl",
"8yyf",
"8yyg",
"8yyh",
"8yyi",
"8yyj",
"8yyk"
] | 25 | [
"PUB00050660",
"PUB00059561",
"PUB00138074",
"PUB00154212",
"PUB00154213"
] | [
"18204464",
"21893285",
"21893286",
"25940620",
"26253740"
] | [
"Structural insights into the dual activity of RNase J.",
"Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1.",
"Molecular basis for the recognition and cleavage of RNA by the bifunctional 5'-3' exo/endoribonuclease RNase J.",
"Structural insig... | [
2008,
2011,
2011,
2015,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctSwt2",
"metagenomes"
] | [
704,
20543,
1029,
1,
363
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
21
] | 3 | true | Domain | Ribonuclease J, beta-CASP domain | Ribonuclease J, beta-CASP domain | RNase_J_b_CASP | 9 |
IPR055134 | 55,134 | RECK, EGF-like 2 domain | EGF2_RECK_dom | Domain | 1,604 | false | false | This domain is found in human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and similar proteins mainly from vertebrates. RECK is a membrane-anchored glycoprotein that plays a role in Wnt7-specific responses in the central nervous system angiogenesis and in the blood-brain barrier regulation [ , ]. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22955"
] | [
"EGF2_RECK"
] | [
1604
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 3 | [
"8tzp"
] | 1 | [
"PUB00154871",
"PUB00154885",
"PUB00154886"
] | [
"37852257",
"28289266",
"30026314"
] | [
"Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.",
"Wnt proteins synergize to activate β-catenin signaling.",
"A molecular mechanism for Wnt ligand-specific signaling."
] | [
2023,
2017,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1604
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
6
] | 4 | true | Domain | RECK, EGF-like 2 domain | RECK, EGF-like 2 domain | EGF2_RECK_dom | 9 |
IPR055135 | 55,135 | Protein arginine N-methyltransferase domain | PRMT_dom | Domain | 24,376 | false | false | This entry represents a domain found C-terminal in Protein arginine N-methyltransferase 1 and twice in Protein arginine N-methyltransferase 7. This domain is also found in histone-arginine methyltransferases CARM1 and CARMER. CARM1 methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl resid... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22528"
] | [
"PRMT_C"
] | [
24376
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"2.1.1",
"2.1.1.319",
"R-BTA-3214858",
"R-BTA-8936459",
"R-CEL-3214858",
"R-CEL-8936459",
"R-DDI-3214858",
"R-DDI-8876725",
"R-DDI-9018519",
"R-DME-400206",
"R-DME-9018519",
"R-DME-9707564",
"R-DRE-3214858",
"R-DRE-400206",
"R-DRE-8936459",
"R-DRE-9018519",
"R-DRE-9707564",
"R-HSA-... | [
"EC:2.1.1",
"EC:2.1.1.319",
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-8936459",
"REACTOME:R-CEL-3214858",
"REACTOME:R-CEL-8936459",
"REACTOME:R-DDI-3214858",
"REACTOME:R-DDI-8876725",
"REACTOME:R-DDI-9018519",
"REACTOME:R-DME-400206",
"REACTOME:R-DME-9018519",
"REACTOME:R-DME-9707564",
"REAC... | 58 | [
"1f3l",
"1g6q",
"1or8",
"1orh",
"1ori",
"2fyt",
"2v74",
"2v7e",
"2y1w",
"2y1x",
"3b3f",
"3b3g",
"3b3j",
"3q7e",
"3r0q",
"3smq",
"3wst",
"3x0d",
"4c03",
"4c04",
"4c05",
"4c06",
"4c07",
"4c08",
"4c4a",
"4hc4",
"4hsg",
"4ikp",
"4lwo",
"4lwp",
"4qpp",
"4qqk"... | 158 | [
"PUB00024774",
"PUB00025146",
"PUB00028123",
"PUB00049607",
"PUB00059818",
"PUB00060080",
"PUB00060081",
"PUB00060102",
"PUB00100615",
"PUB00128165",
"PUB00154931"
] | [
"10899106",
"11101900",
"12737817",
"17882261",
"21410432",
"17010682",
"19300908",
"18057026",
"12237300",
"19405910",
"16497732"
] | [
"Crystal structure of the conserved core of protein arginine methyltransferase PRMT3.",
"The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.",
"Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides.",
"Insights into... | [
2000,
2000,
2003,
2007,
2011,
2006,
2009,
2007,
2002,
2009,
2006
] | 11 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"metagenomes"
] | [
289,
24081,
2,
4
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
31,
2,
27,
15,
78,
28,
2,
11,
36,
1,
2,
60
] | 12 | true | Domain | Protein arginine N-methyltransferase domain | Protein arginine N-methyltransferase domain | PRMT_dom | 2 |
IPR055136 | 55,136 | LFE_1968-like | LFE_1968-like | Family | 80 | false | false | This protein family includes a group of uncharacterised prokaryotic proteins that adopt an α/β structures with similarity to haem iron utilisation proteins, such as LFE_1968 from Leptospirillum ferrooxidans ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22684"
] | [
"LFE_1968-like"
] | [
80
] | 1 | [] | [] | [] | 0 | [
"3na2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"Nitrososphaerota",
"unclassified sequences"
] | [
9,
3,
51,
17
] | 4 | [] | [] | 0 | true | Family | LFE_1968-like | LFE_1968-like | LFE_1968-like | 3 |
IPR055137 | 55,137 | AlkA-like, TATA-box binding protein-like domain | AlkA-like_TBP-like | Domain | 7 | false | false | This entry represents a TATA-box binding protein (TBP)-like domain present at the N-terminal end of AlkA from Archaeoglobus fulgidus ( ). AlkA is a glycosylase involved in base excision repair, capable of repairing mutagenic lesions such as N1-methyladenine (m1A) and N3-methylcytosine (m3C) found in DNA [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22394"
] | [
"AfAlkA-like_TBP-like"
] | [
7
] | 1 | [] | [] | [] | 0 | [
"2jhj",
"2jhn"
] | 2 | [
"PUB00041936"
] | [
"17396151"
] | [
"Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Archaeoglobus fulgidus"
] | [
7
] | 1 | [] | [] | 0 | true | Domain | AlkA-like, TATA-box binding protein-like domain | AlkA-like, TATA-box binding protein-like domain | AlkA-like_TBP-like | 9 |
IPR055138 | 55,138 | Neopullulanase-like, C-terminal domain | Neopullulanase-like_C | Domain | 126 | false | false | This entry represents the C-terminal all-β domain found in (Neo)pullulanase ( ) from Thermus thermophilus ( ) and similar bacterial sequences. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22460"
] | [
"Neopullulanase-like_C"
] | [
126
] | 1 | [] | [] | [] | 0 | [
"2z1k"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
126
] | 1 | [] | [] | 0 | true | Domain | Neopullulanase-like, C-terminal domain | Neopullulanase-like, C-terminal domain | Neopullulanase-like_C | 4 |
IPR055139 | 55,139 | Interleukin-18-binding protein-like domain | IL18BP-like_dom | Domain | 397 | false | false | This entry represents a domain found in human Interleukin-18-binding protein (IL18BP, [ ]) and similar sequences from vertebrates and virus. IL18BP is unique among the diverse family of mammalian and poxvirus IL18BPs in that it uses a bivalent binding mode and a unique set of interacting residues for binding IL18 [ ]. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22009"
] | [
"YLDV-IL18BP-like"
] | [
397
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9008059",
"R-HSA-9012546",
"R-MMU-9012546"
] | [
"REACTOME:R-HSA-9008059",
"REACTOME:R-HSA-9012546",
"REACTOME:R-MMU-9012546"
] | 3 | [
"4eee",
"4ekx",
"7al7"
] | 3 | [
"PUB00089963",
"PUB00154334"
] | [
"10655506",
"22927815"
] | [
"Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.",
"A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein."
] | [
2000,
2012
] | 2 | [
"IPR007110"
] | [] | 1 | 0 | 1 | [
"Chordopoxvirinae",
"Gnathostomata"
] | [
26,
371
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4
] | 3 | true | Domain | Interleukin-18-binding protein-like domain | Interleukin-18-binding protein-like domain | IL18BP-like_dom | 6 |
IPR055140 | 55,140 | Thiolase, C-terminal domain 2 | Thiolase_C_2 | Domain | 31,922 | false | false | This domain is found C-terminal in a group of thiolases from all cellular organisms that are not included in . Thiolases are essential CoA-dependent enzymes in lipid metabolism. This domain folds into a four-stranded antiparallel β-sheet with α-helices packed on one side [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22691"
] | [
"Thiolase_C_1"
] | [
31922
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.1",
"R-HSA-193368",
"R-HSA-2046106",
"R-HSA-389887",
"R-HSA-9033241",
"R-HSA-9033500",
"R-MMU-193368",
"R-MMU-2046106",
"R-MMU-389887",
"R-MMU-9033241",
"R-RNO-193368",
"R-RNO-2046106",
"R-RNO-389887",
"R-RNO-9033241"
] | [
"EC:2.3.1",
"REACTOME:R-HSA-193368",
"REACTOME:R-HSA-2046106",
"REACTOME:R-HSA-389887",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9033500",
"REACTOME:R-MMU-193368",
"REACTOME:R-MMU-2046106",
"REACTOME:R-MMU-389887",
"REACTOME:R-MMU-9033241",
"REACTOME:R-RNO-193368",
"REACTOME:R-RNO-2046106",
... | 14 | [
"3zbg",
"3zbk",
"3zbl",
"3zbn",
"4bi9",
"4bia",
"4u4e",
"4yzo",
"5ab4",
"5ab5",
"5ab6",
"5ab7",
"5lnq",
"5lot",
"5m3k",
"5mg5",
"6esq",
"6et9",
"6hrv",
"6hsj",
"6hsp",
"6ok1",
"7pxp",
"7pyt",
"7yvy",
"7yxm",
"9myr"
] | 27 | [
"PUB00154887"
] | [
"23909465"
] | [
"Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2521,
24226,
4394,
781
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
2,
4,
5,
1,
1,
5
] | 7 | true | Domain | Thiolase, C-terminal domain 2 | Thiolase, C-terminal domain 2 | Thiolase_C_2 | 6 |
IPR055141 | 55,141 | Transcriptional adapter 2-alpha/beta-like domain | TADA2A_B-like_dom | Domain | 7,035 | false | false | This domain is found in human Transcriptional adapter 2-alpha (TADA2A), Transcriptional adapter 2-beta (TADA2B) and similar eukaryotic proteins. TADA2A is a component of the ATAC complex that plays a role in chromatin remodelling [ ]. TADA2B differs both biochemically and functionally from TADA2A. TADA2B interacts sele... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22941"
] | [
"TADA2A-like_3rd"
] | [
7035
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9772755",
"R-DME-5689880",
"R-DRE-5689880",
"R-HSA-3214847",
"R-HSA-5689880",
"R-HSA-9772755",
"R-MMU-9772755",
"R-RNO-9772755",
"R-SCE-5689880",
"R-SPO-5689880"
] | [
"REACTOME:R-BTA-9772755",
"REACTOME:R-DME-5689880",
"REACTOME:R-DRE-5689880",
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-9772755",
"REACTOME:R-RNO-9772755",
"REACTOME:R-SCE-5689880",
"REACTOME:R-SPO-5689880"
] | 10 | [] | 0 | [
"PUB00067689",
"PUB00154888"
] | [
"22644376",
"12972612"
] | [
"CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.",
"A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription."
] | [
2012,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7035
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
4,
3,
10,
5,
1,
4,
8,
1,
1,
23
] | 12 | true | Domain | Transcriptional adapter 2-alpha/beta-like domain | Transcriptional adapter 2-alpha/beta-like domain | TADA2A_B-like_dom | 5 |
IPR055143 | 55,143 | Membrane-bound transcription factor site-1 protease-like, N-terminal domain | MBTP1_N | Domain | 2,404 | false | false | This entry represents a domain found N-terminal in a family of membrane bound serine proteases from animals and plants, including the human member Membrane-bound transcription factor site-1 protease (MBTP1) [ , , ]. Members of this family are involved in regulated intramembrane proteolysis (RIP) of various substrates, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23001"
] | [
"MBTP1_N"
] | [
2404
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.112",
"R-HSA-1655829",
"R-HSA-381033",
"R-HSA-381426",
"R-HSA-8874177",
"R-HSA-8874211",
"R-HSA-8957275",
"R-HSA-8963889",
"R-MMU-1655829",
"R-MMU-381033",
"R-MMU-381426",
"R-MMU-8874177",
"R-MMU-8874211",
"R-MMU-8957275",
"R-RNO-1655829",
"R-RNO-381033",
"R-RNO-381426",
"R... | [
"EC:3.4.21.112",
"REACTOME:R-HSA-1655829",
"REACTOME:R-HSA-381033",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8874177",
"REACTOME:R-HSA-8874211",
"REACTOME:R-HSA-8957275",
"REACTOME:R-HSA-8963889",
"REACTOME:R-MMU-1655829",
"REACTOME:R-MMU-381033",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-88741... | 20 | [
"8uw8",
"8uwc",
"9csd"
] | 3 | [
"PUB00154941",
"PUB00154942",
"PUB00154943",
"PUB00154944"
] | [
"12782636",
"21719679",
"30046013",
"34349020"
] | [
"A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.",
"A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.",
"Site-1 protease deficiency causes human skeletal dysplasia... | [
2003,
2011,
2018,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2404
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
2,
1,
4,
3,
4
] | 7 | true | Domain | Membrane-bound transcription factor site-1 protease-like, N-terminal domain | Membrane-bound transcription factor site-1 protease-like, N-terminal domain | MBTP1_N | 3 |
IPR055144 | 55,144 | tRNA-intron endonuclease SEN2-like, N-terminal domain | SEN2-like_N | Domain | 3 | false | false | This entry represents the N-terminal domain of tRNA-intron endonuclease from Aeropyrum pernix ( , [ , ]) and similar archaeal sequences. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22502"
] | [
"SEN2-like_N"
] | [
3
] | 1 | [] | [] | [] | 0 | [
"3ajv",
"3p1z"
] | 2 | [
"PUB00154228",
"PUB00154229"
] | [
"21050862",
"21846775"
] | [
"A conserved lysine residue in the crenarchaea-specific loop is important for the crenarchaeal splicing endonuclease activity.",
"Cleavage of intron from the standard or non-standard position of the precursor tRNA by the splicing endonuclease of Aeropyrum pernix, a hyper-thermophilic Crenarchaeon, involves a nove... | [
2011,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Aeropyrum"
] | [
3
] | 1 | [] | [] | 0 | true | Domain | tRNA-intron endonuclease SEN2-like, N-terminal domain | tRNA-intron endonuclease SEN2-like, N-terminal domain | SEN2-like_N | 2 |
IPR055145 | 55,145 | PSV hypothetical protein ORF131-like domain | PSV_ORF131-like_dom | Domain | 2 | false | false | This domain is found in the uncharacterised protein from Pyrobaculum spherical virus (PSV), also known as ORF131, and similar sequences from virus and archaeal prophagues. It adopts a two-layered α-β configuration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22415"
] | [
"PSV_ORF131-like_dom"
] | [
2
] | 1 | [] | [] | [] | 0 | [
"2x5c"
] | 1 | [
"PUB00054436"
] | [
"20419351"
] | [
"The Scottish Structural Proteomics Facility: targets, methods and outputs."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Alphaglobulovirus"
] | [
2
] | 1 | [] | [] | 0 | true | Domain | PSV hypothetical protein ORF131-like domain | PSV hypothetical protein ORF131-like domain | PSV_ORF131-like_dom | 3 |
IPR055146 | 55,146 | Phage DNA Adenine Methylase-like domain 2 | DAM-like-phage2 | Domain | 8 | false | false | This domain, which is found in a group of proteins from bacteroidetes, has been characterised as part of a nucleic acid modifying system in certain phages. This system may modify tRNAs that are encoded adjacent to the system on the genome. These tRNAs are then possibly packaged into the viral head, to render them resis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22556"
] | [
"DAM-like-phage2"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153826"
] | [
"36968430"
] | [
"New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
8
] | 1 | [] | [] | 0 | true | Domain | Phage DNA Adenine Methylase-like domain 2 | Phage DNA Adenine Methylase-like domain 2 | DAM-like-phage2 | 5 |
IPR055147 | 55,147 | Phage G20C small terminase, C-terminal domain | TerS_C | Domain | 3 | false | false | This domain is found at the C-terminal of terminase small subunit (TerS) from Thermus phage G20c, which oligomerises into a nonamer that binds DNA, stimulates terminase large subunit ATPase activity, and inhibits TerL nuclease activity. TerS is organised into an N-terminal helix-turn-helix (HTH) motif ( ) followed by a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22412"
] | [
"TerS_C"
] | [
3
] | 1 | [] | [] | [] | 0 | [
"4xvn",
"6ejq",
"6v1i"
] | 3 | [
"PUB00151796"
] | [
"32014998"
] | [
"A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Oshimavirus"
] | [
3
] | 1 | [] | [] | 0 | true | Domain | Phage G20C small terminase, C-terminal domain | Phage G20C small terminase, C-terminal domain | TerS_C | 5 |
IPR055148 | 55,148 | ZW10, C-terminal helical domain | ZW10_C_2 | Domain | 4,485 | false | false | This entry represents the last of the α-helical repeat domains of Zw10 protein. Zw10 protein, in the context of the conserved Rod-Zwilch-Zw10 (RZZ) complex, is required for correct metaphase check-pointing during mitosis [ , ] and it is also important in vesicle transport between Golgi and ER as part of a second comple... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22766"
] | [
"ZW10_C2"
] | [
4485
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-6811434",
"R-DME-6811434",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-6811434",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-6811434",
"R-MMU-68877",
"R-MMU-9648025",
"R-RNO-141444",
... | [
"REACTOME:R-CEL-6811434",
"REACTOME:R-DME-6811434",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-6811434",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-... | 23 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00013411",
"PUB00100047",
"PUB00100050"
] | [
"11146660",
"11146659",
"34061181",
"22685323"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.",
"Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.",
"The Drosophila RZZ complex - roles in membrane traf... | [
2000,
2000,
2021,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4485
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
1,
3,
1,
1,
5,
3,
13
] | 10 | true | Domain | ZW10, C-terminal helical domain | ZW10, C-terminal helical domain | ZW10_C_2 | 1 |
IPR055149 | 55,149 | Alpha-1,3-glucanase, catalytic domain, D2 | Agl_cat_D2 | Domain | 3,270 | false | false | This entry represents a domain found at the C-terminal end of a group of Alpha-1,3-glucanases, including the members from from Paenibacillus glycanilyticus and Niallia circulans (Bacillus circulans) [ , ]. This domain, found C-terminal in the catalytic domain, folds into a right-handed β-helix fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22816"
] | [
"CatAgl_D2"
] | [
3270
] | 1 | [] | [] | [] | 0 | [
"5zru",
"6k0m",
"6k0n",
"6k0p",
"6k0q",
"6k0s",
"6k0u",
"6k0v"
] | 8 | [
"PUB00153858",
"PUB00154938"
] | [
"31788942",
"31653959"
] | [
"Structural insights into substrate recognition and catalysis by glycoside hydrolase family 87 α-1,3-glucanase from Paenibacillus glycanilyticus FH11.",
"Crystal structure of the catalytic unit of GH 87-type α-1,3-glucanase Agl-KA from Bacillus circulans."
] | [
2020,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Arthrobacter phage Peas",
"Bacteria",
"Eukaryota",
"mine drainage metagenome"
] | [
1,
3248,
19,
2
] | 4 | [] | [] | 0 | true | Domain | Alpha-1,3-glucanase, catalytic domain, D2 | Alpha-1,3-glucanase, catalytic domain, D2 | Agl_cat_D2 | 6 |
IPR055150 | 55,150 | Iron hydrogenase 1-like, iron-sulfur centre-binding domain | Fe_hydrogense_Fe-S_bd | Domain | 123 | false | false | This entry represents a Fe-S centre binding domain found in iron hydrogenases mainly from Clostridium species [ , , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22609"
] | [
"Fe_hydrogense_Fe-S_bd"
] | [
123
] | 1 | [] | [] | [] | 0 | [
"1c4a",
"1c4c",
"1feh",
"3c8y",
"4xdc",
"4xdd",
"5byq",
"5byr",
"5bys",
"5la3",
"5oef",
"6gly",
"6glz",
"6gm0",
"6gm1",
"6gm2",
"6gm3",
"6gm4",
"6gm8",
"6h63",
"6n59",
"6n6p",
"6nac",
"6yf4",
"7qhf",
"8aio",
"8aj6",
"8aln",
"8ap2",
"8cjy",
"8pvm",
"8qm3"... | 32 | [
"PUB00023853",
"PUB00153941",
"PUB00153942",
"PUB00153943",
"PUB00153944"
] | [
"10529166",
"29896366",
"28722011",
"30413719",
"32796105"
] | [
"Binding of exogenously added carbon monoxide at the active site of the iron-only hydrogenase (CpI) from Clostridium pasteurianum.",
"A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.",
"Accumulating the hydride state in the catalytic cycle of [FeFe]-hydrogenases.",
"Crystallograph... | [
1999,
2016,
2017,
2018,
2020
] | 5 | [
"IPR019574"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"bioreactor metagenome"
] | [
122,
1
] | 2 | [] | [] | 0 | true | Domain | Iron hydrogenase 1-like, iron-sulfur centre-binding domain | Iron hydrogenase 1-like, iron-sulfur centre-binding domain | Fe_hydrogense_Fe-S_bd | 2 |
IPR055151 | 55,151 | Glycoside Hydrolase Family 113 | GH113 | Family | 2,308 | false | false | This family includes Endo-beta-1,4-mannanase from Alicyclobacillus acidocaldarius and similar bacterial sequences that belong to the Glycoside Hydrolase Family 113 (GH113) [ , ]. It shows a (β/α)8-barrel fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22612"
] | [
"GH113"
] | [
2308
] | 1 | [] | [] | [] | 0 | [
"3civ",
"4cd6",
"4cd7",
"4cd8",
"5ylh",
"5yli",
"5ylk",
"5yll",
"5z4t",
"7dv7",
"7dvj",
"7dvz",
"7dw8",
"7dwa"
] | 14 | [
"PUB00051016",
"PUB00143658",
"PUB00143659"
] | [
"18755688",
"24339341",
"29871927"
] | [
"Biochemical and structural characterization of the intracellular mannanase AaManA of Alicyclobacillus acidocaldarius reveals a novel glycoside hydrolase family belonging to clan GH-A.",
"Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate.",
"St... | [
2008,
2014,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"ecological metagenomes"
] | [
14,
2204,
3,
55,
32
] | 5 | [] | [] | 0 | true | Family | Glycoside Hydrolase Family 113 | Glycoside Hydrolase Family 113 | GH113 | 4 |
IPR055152 | 55,152 | Transketolase-like, C-terminal domain | Transketolase-like_C_2 | Domain | 49,183 | false | false | This entry represents a C-terminal domain found in transketolase and transketolase-like enzymes [ , , ], such as pyruvate dehydrogenase E1 component from Escherichia coli (OPD1) [ ]. The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. The E1 component is a t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22613"
] | [
"Transketolase_C_1"
] | [
49183
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.2.1.1",
"PWY-1861",
"PWY-5723",
"PWY-6901",
"PWY-8178"
] | [
"EC:2.2.1.1",
"METACYC:PWY-1861",
"METACYC:PWY-5723",
"METACYC:PWY-6901",
"METACYC:PWY-8178"
] | 5 | [
"1ay0",
"1gpu",
"1itz",
"1l8a",
"1ngs",
"1qgd",
"1r9j",
"1rp7",
"1tka",
"1tkb",
"1tkc",
"1trk",
"2e6k",
"2g25",
"2g28",
"2g67",
"2iea",
"2qta",
"2qtc",
"2r5n",
"2r8o",
"2r8p",
"3hyl",
"3kom",
"3l84",
"3lpl",
"3lq2",
"3lq4",
"3m34",
"3m49",
"3m6l",
"3m7i"... | 82 | [
"PUB00011731",
"PUB00021856",
"PUB00023456",
"PUB00030580",
"PUB00162220",
"PUB00162221"
] | [
"11955070",
"12913150",
"9398292",
"15149284",
"16045627",
"20675489"
] | [
"Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.",
"Structure and properties of an engineered transketolase from maize.",
"Identification of catalytically important residues in yeast transketolase.",
"Transketolase from Leishmania mexicana h... | [
2002,
2003,
1997,
2004,
2005,
2010
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
23,
42787,
5433,
940
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
11,
3,
1,
8,
2,
1,
9
] | 7 | true | Domain | Transketolase-like, C-terminal domain | Transketolase-like, C-terminal domain | Transketolase-like_C_2 | 6 |
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