LiteFold/InterPro · Datasets at Hugging Face

IPR054925

54,925

Glucose-binding protein GlcS

GlcS_GBP

Family

56

true

false

The Glucose-binding protein GlcS is a component of the ABC transporter complex GlcSTUV, which is involved in glucose uptake in Saccharolobus solfataricus. This protein binds glucose and can also bind galactose and mannose. The binding of glucose by GlcS is strongly inhibited by the presence of galactose and mannose. Gl...

[]

0

[ "NCBIFAM" ]

[ "NF040930" ]

[ "GlcS_GBP" ]

[ 56 ]

1

[]

0

[]

0

[ "PUB00013790", "PUB00106073" ]

[ "11260467", "10400586" ]

[ "Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters.", "Glucose transport in the extremely thermoacidophilic Sulfolobus solfataricus involves a high-affinity membrane-integrated binding protein." ]

[ 2001, 1999 ]

2

[]

0

null

[ "Archaea" ]

[ 56 ]

1

[]

0

true

Family

Glucose-binding protein GlcS

GlcS_GBP

4

IPR054926

54,926

Citrate synthase family

Cit_synThplmales

Family

60

true

false

Citrate synthase is an enzyme that catalyzes the first step of the citric acid cycle (Krebs cycle), which is the synthesis of citrate from oxaloacetate and acetyl-CoA. This enzyme is allosterically inhibited by NADH, indicating a regulatory role in cellular metabolism. Members of the citrate synthase family are found a...

[]

0

[ "NCBIFAM" ]

[ "NF041157" ]

[ "Cit_synThplmales" ]

[ 60 ]

1

[]

0

[ "1o7x", "1vgm", "2ifc", "2r26", "2r9e", "4ybo", "6abv", "6abw" ]

8

[ "PUB00106208", "PUB00106209" ]

[ "2269303", "7704526" ]

[ "Citrate synthase from the thermophilic archaebacterium Thermoplasma acidophilium. Cloning and sequencing of the gene.", "The crystal structure of citrate synthase from the thermophilic archaeon, Thermoplasma acidophilum." ]

[ 1990, 1994 ]

2

[]

0

null

[ "Archaea" ]

[ 60 ]

1

[]

0

true

Family

Citrate synthase family

Cit_synThplmales

7

IPR054927

54,927

Glucose ABC transporter permease GlcU

GlcU_transporter

Family

58

true

false

This entry represents the glucose import system permease protein GlcU, which is part of the ABC transporter complex GlcSTUV involved in glucose uptake. The protein is responsible for the translocation of glucose across the membrane. It belongs to the binding-protein-dependent transport system permease family. The prote...

[]

0

[ "NCBIFAM" ]

[ "NF040932" ]

[ "GlcU_transporter" ]

[ 58 ]

1

[]

0

[]

0

[ "PUB00013790", "PUB00106073" ]

[ "11260467", "10400586" ]

[ "Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters.", "Glucose transport in the extremely thermoacidophilic Sulfolobus solfataricus involves a high-affinity membrane-integrated binding protein." ]

[ 2001, 1999 ]

2

[]

0

null

[ "Archaea" ]

[ 58 ]

1

[]

0

true

Family

Glucose ABC transporter permease GlcU

GlcU_transporter

8

IPR054928

54,928

Fatty-acid--CoA ligase FadD21

FAAL_FadD21

Family

62

true

false

This entry represents the fatty-acid--CoA ligase FadD21, also known as fatty-acid--AMP ligase FAAL21/FadD21. These enzymes belong to the ATP-dependent AMP-binding enzyme family and are involved in the activation of fatty acids by forming a fatty acyl-CoA thioester. The proteins matched by this entry are found in variou...

[]

0

[ "NCBIFAM" ]

[ "NF038337" ]

[ "FAAL_FadD21" ]

[ 62 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "6.2.1.-", "PWY-301", "PWY-5045", "PWY-5136", "PWY-5660", "PWY-5752", "PWY-5922", "PWY-5923", "PWY-5924", "PWY-5927", "PWY-5958", "PWY-6457", "PWY-6593", "PWY-6670", "PWY-6722", "PWY-6799", "PWY-6926", "PWY-6948", "PWY-7007", "PWY-7288", "PWY-735", "PWY-7462", "PWY-7536",...

[ "EC:6.2.1.-", "METACYC:PWY-301", "METACYC:PWY-5045", "METACYC:PWY-5136", "METACYC:PWY-5660", "METACYC:PWY-5752", "METACYC:PWY-5922", "METACYC:PWY-5923", "METACYC:PWY-5924", "METACYC:PWY-5927", "METACYC:PWY-5958", "METACYC:PWY-6457", "METACYC:PWY-6593", "METACYC:PWY-6670", "METACYC:PWY-67...

53

[]

0

[ "PUB00077564", "PUB00095586" ]

[ "25124040", "19182784" ]

[ "Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis.", "Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis." ]

[ 2014, 2009 ]

2

[]

0

null

[ "Mycobacterium" ]

[ 62 ]

1

[]

0

true

Family

Fatty-acid--CoA ligase FadD21

FAAL_FadD21

6

IPR054929

54,929

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

dPGM_arch

Family

63

true

false

This entry represents 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, an enzyme that catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. This enzyme belongs to the phosphoglycerate mutase family and is found in Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 1...

[]

0

[ "NCBIFAM" ]

[ "NF038349" ]

[ "dPGM_arch" ]

[ 63 ]

1

[]

0

[]

0

[ "PUB00055097" ]

[ "17576516" ]

[ "Characterization of cofactor-dependent and cofactor-independent phosphoglycerate mutases from Archaea." ]

[ 2007 ]

1

[]

0

null

[ "Archaea" ]

[ 63 ]

1

[]

0

true

Family

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

dPGM_arch

2

IPR054930

54,930

GTP-dependent dephospho-CoA kinase family

deph_CoA_kin_Thcocales

Family

44

true

false

GTP-dependent dephospho-CoA kinase (DPCK) catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). This enzyme is a member of the GTP-dependent DPCK family and is found in various archaeal species, including Pyrococcus horikoshii, Pyrococcus abyssi, Thermococ...

[]

0

[ "NCBIFAM" ]

[ "NF041125" ]

[ "deph_CoA_kin_Thcocales" ]

[ 44 ]

1

[ "EC", "METACYC" ]

[ "2.7.1.237", "PWY-8342" ]

[ "EC:2.7.1.237", "METACYC:PWY-8342" ]

2

[ "8jvc", "8jvf", "8jvg" ]

3

[ "PUB00093757" ]

[ "31337720" ]

[ "Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea." ]

[ 2019 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 44 ]

1

[]

0

true

Family

GTP-dependent dephospho-CoA kinase family

deph_CoA_kin_Thcocales

8

IPR054931

54,931

Lysyl aminopeptidase

lys_aminopep_Arch

Family

42

true

false

Lysyl aminopeptidase is an enzyme that hydrolyzes di-, tri- and tetrapeptides with a lysine as the N-terminal amino acid and with Gly, Lys, Ala, Phe or Glu in the second position. This enzyme belongs to the peptidase M42 family and is found in Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1). The enz...

[]

0

[ "NCBIFAM" ]

[ "NF040822" ]

[ "lys_aminopep_Arch" ]

[ 42 ]

1

[]

0

[ "2pe3", "2wzn", "4x8i" ]

3

[ "PUB00105996" ]

[ "15743956" ]

[ "Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus." ]

[ 2005 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 42 ]

1

[]

0

true

Family

Lysyl aminopeptidase

lys_aminopep_Arch

7

IPR054932

54,932

Rhamnosyl O-methyltransferase family

RhmsylMtase

Family

72

true

false

Rhamnosyl O-methyltransferase enzymes catalyze the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD). These enzymes are found in various strains of Mycobact...

[]

0

[ "NCBIFAM" ]

[ "NF045824" ]

[ "RhmsylMtase" ]

[ 72 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[]

0

[ "PUB00053670" ]

[ "15292265" ]

[ "Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex." ]

[ 2004 ]

1

[]

0

null

[ "Mycobacteriaceae" ]

[ 72 ]

1

[]

0

true

Family

Rhamnosyl O-methyltransferase family

RhmsylMtase

1

IPR054933

54,933

Oxalate oxidoreductase subunit delta

OxalOxred_delta

Family

37

true

false

Oxalate oxidoreductase subunit delta is an enzyme that catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. This enzyme does not require coenzyme A as a cosubstrate and enables anaerobic growth on oxalate, wh...

[]

0

[ "NCBIFAM" ]

[ "NF045790" ]

[ "OxalOxred_delta" ]

[ 37 ]

1

[]

0

[ "5c4i", "5exd", "5exe" ]

3

[ "PUB00078738" ]

[ "20956531" ]

[ "Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria" ]

[ 37 ]

1

[]

0

true

Family

Oxalate oxidoreductase subunit delta

OxalOxred_delta

4

IPR054934

54,934

Leucine/methionine racemase

LeuMetRace

Family

41

true

false

Leucine/methionine racemase is an amino acid racemase with moderate substrate specificity. It is primarily active toward leucine, which is the preferred substrate, and methionine. The enzyme also exhibits lower levels of activity toward phenylalanine, alanine, and serine. It belongs to the class-III pyridoxal-phosphate...

[]

0

[ "NCBIFAM" ]

[ "NF045634" ]

[ "LeuMetRace" ]

[ 41 ]

1

[]

0

[]

0

[ "PUB00154767" ]

[ "33468590" ]

[ "TK1211 Encodes an Amino Acid Racemase towards Leucine and Methionine in the Hyperthermophilic Archaeon Thermococcus kodakarensis." ]

[ 2021 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 41 ]

1

[]

0

true

Family

Leucine/methionine racemase

LeuMetRace

1

IPR054935

54,935

Polysaccharide lyase 17 family

Alg_lyase

Family

49

true

false

Alginate lyase is an enzyme that catalyzes the depolymerization of alginate via a beta-elimination mechanism, cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues. This enzyme acts specifically on alginate and each of its block structures, with the highest activity toward poly-beta-D-mannuronate (p...

[]

0

[ "NCBIFAM" ]

[ "NF042990" ]

[ "Alg_lyase" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00153625" ]

[ "26913076" ]

[ "Engineering broad-spectrum digestion of polyuronides from an exolytic polysaccharide lyase." ]

[ 2016 ]

1

[]

0

null

[ "Knufia peltigerae", "Lysobacteraceae" ]

[ 1, 48 ]

2

[]

0

true

Family

Polysaccharide lyase 17 family

Alg_lyase

2

IPR054936

54,936

O6-methylguanine-DNA methyltransferase

DNA_protcyst_Mta_Thcoc

Family

42

true

false

Methylated-DNA--protein-cysteine methyltransferase (MGMT) is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. This enzyme repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue i...

[]

0

[ "NCBIFAM" ]

[ "NF041132" ]

[ "DNA_protcyst_Mta_Thcoc" ]

[ 42 ]

1

[ "EC" ]

[ "2.1.1.63" ]

[ "EC:2.1.1.63" ]

1

[ "1mgt" ]

1

[ "PUB00027330", "PUB00106190" ]

[ "10497033", "9613574" ]

[ "Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase.", "The O6-methylguanine-DNA methyltransferase from the hyperthermophilic archaeon Pyrococcus sp. KOD1: a thermostable repair enzyme." ]

[ 1999, 1998 ]

2

[]

0

null

[ "Thermococcaceae" ]

[ 42 ]

1

[]

0

true

Family

O6-methylguanine-DNA methyltransferase

DNA_protcyst_Mta_Thcoc

1

IPR054937

54,937

CoaD family phosphopantetheine adenylyltransferase

CoaD_Thcocales

Family

41

true

false

Phosphopantetheine adenylyltransferase (CoaD) is an enzyme that reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. This enzyme belongs to the eukaryotic CoaD family and is found in various thermophilic archaea, including Thermococcus kodakarensis,...

[]

0

[ "NCBIFAM" ]

[ "NF041124" ]

[ "CoaD_Thcocales" ]

[ 41 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.7.3", "PWY-7851", "PWY-8342" ]

[ "EC:2.7.7.3", "METACYC:PWY-7851", "METACYC:PWY-8342" ]

3

[]

0

[ "PUB00093757" ]

[ "31337720" ]

[ "Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea." ]

[ 2019 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 41 ]

1

[]

0

true

Family

CoaD family phosphopantetheine adenylyltransferase

CoaD_Thcocales

9

IPR054939

54,939

2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase

KDG_KDGal_kin

Family

52

true

false

This entry represents 2-dehydro-3-deoxygluconokinase (KDGK) and 2-dehydro-3-deoxygalactonokinase (KDGalK) enzymes. These enzymes are involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. They catalyze the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3...

[]

0

[ "NCBIFAM" ]

[ "NF040938" ]

[ "KDG_KDGal_kin" ]

[ 52 ]

1

[]

0

[ "1wye", "2dcn", "2v78", "2var" ]

4

[ "PUB00106077", "PUB00106078" ]

[ "16794308", "19018105" ]

[ "Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.", "The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase." ]

[ 2006, 2008 ]

2

[]

0

null

[ "Thermoproteati" ]

[ 52 ]

1

[]

0

true

Family

2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase

KDG_KDGal_kin

9

IPR054940

54,940

L-prolyl-[peptidyl-carrier protein] dehydrogenase

ProlPCPDhRedW

Family

64

true

false

L-prolyl-[peptidyl-carrier protein] dehydrogenase, also known as L-prolyl-[prolyl-carrier protein] dehydrogenase, is an enzyme involved in the biosynthesis of undecylprodigiosin in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). This enzyme catalyzes the desaturation of L-prolyl-[prolyl-carrier protein] t...

[]

0

[ "NCBIFAM" ]

[ "NF045652" ]

[ "ProlPCPDhRedW" ]

[ 64 ]

1

[]

0

[]

0

[ "PUB00096314", "PUB00096315" ]

[ "11880032", "11514230" ]

[ "Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.", "Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Actinomycetes" ]

[ 64 ]

1

[]

0

true

Family

L-prolyl-[peptidyl-carrier protein] dehydrogenase

ProlPCPDhRedW

6

IPR054941

54,941

NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit gamma

sulfhyd_HydG

Family

39

true

false

This entry represents the gamma subunit of NADPH-dependent hydrogenase/sulfhydrogenase 1, also known as sulfhydrogenase 1 subunit gamma. This enzyme complex is found in Pyrococcus furiosus and functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity. The beta and gamma subunits form t...

[]

0

[ "NCBIFAM" ]

[ "NF040835" ]

[ "sulfhyd_HydG" ]

[ 39 ]

1

[]

0

[ "9nez", "9nf0" ]

2

[ "PUB00033242", "PUB00106003", "PUB00106005" ]

[ "7704275", "11265463", "8389482" ]

[ "Characterization of the locus encoding the [Ni-Fe] sulfhydrogenase from the archaeon Pyrococcus furiosus: evidence for a relationship to bacterial sulfite reductases.", "Hydrogenases I and II from Pyrococcus furiosus.", "Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase o...

[ 1995, 2001, 1993 ]

3

[]

0

null

[ "Thermococcaceae" ]

[ 39 ]

1

[]

0

true

Family

NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit gamma

sulfhyd_HydG

1

IPR054942

54,942

Tungsten-containing formylmethanofuran dehydrogenase subunit FwdC

FMH_DH_FwdC

Family

50

true

false

This entry represents the tungsten-containing formylmethanofuran dehydrogenase subunit FwdC. Proteins in this family catalyze the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile and belongs to the FwdC/FmdC family. The activity of this enzyme is crucial...

[]

0

[ "NCBIFAM" ]

[ "NF042910" ]

[ "FMH_DH_FwdC" ]

[ 50 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.7.12", "PWY-5209", "PWY-7784", "PWY-8305" ]

[ "EC:1.2.7.12", "METACYC:PWY-5209", "METACYC:PWY-7784", "METACYC:PWY-8305" ]

4

[ "5t5i", "5t5m", "5t61" ]

3

[ "PUB00015859", "PUB00153614" ]

[ "8575452", "27846502" ]

[ "The tungsten formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic for enzymes containing molybdopterin dinucleotide.", "The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters." ]

[ 1995, 2016 ]

2

[]

0

null

[ "Methanomada group" ]

[ 50 ]

1

[]

0

true

Family

Tungsten-containing formylmethanofuran dehydrogenase subunit FwdC

FMH_DH_FwdC

8

IPR054943

54,943

Chemoreceptor glutamine deamidase/glutamate methylesterase CheD

CheD_Thtga

Family

41

true

false

Chemoreceptor glutamine deamidase/glutamate methylesterase CheD is an enzyme found in Thermotoga maritima, which plays a crucial role in the modification of chemoreceptors (MCPs). CheD deamidates glutamine residues on MCPs, a modification necessary for the proper transmission of conformational signals to the CheA kinas...

[]

0

[ "NCBIFAM" ]

[ "NF041119" ]

[ "CheD_Thtga" ]

[ 41 ]

1

[]

0

[ "2f9z" ]

1

[ "PUB00040594" ]

[ "16469702" ]

[ "A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation." ]

[ 2006 ]

1

[]

0

null

[ "Thermotogae", "bioreactor metagenome" ]

[ 40, 1 ]

2

[]

0

true

Family

Chemoreceptor glutamine deamidase/glutamate methylesterase CheD

CheD_Thtga

4

IPR054944

54,944

Cell wall elongation/penicillin-binding protein regulator TseB

regulator_TseB

Family

67

true

false

This entry represents the cell wall elongation/penicillin-binding protein regulator TseB. The TseB protein is involved in the regulation of cell wall elongation and penicillin-binding proteins in Bacillus subtilis (strain 168). The exact function of TseB remains uncharacterized, but it is believed to play a role in mai...

[]

0

[ "NCBIFAM" ]

[ "NF040668" ]

[ "regulator_TseB" ]

[ 67 ]

1

[]

0

[ "2gu3" ]

1

[ "PUB00105891", "PUB00105892" ]

[ "25954268", "34411374" ]

[ "Tetracycline hypersensitivity of an ezrA mutant links GalE and TseB (YpmB) to cell division.", "Characterization of TseB: A new actor in cell wall elongation in Bacillus subtilis." ]

[ 2015, 2021 ]

2

[]

0

null

[ "Bacillus" ]

[ 67 ]

1

[]

0

true

Family

Cell wall elongation/penicillin-binding protein regulator TseB

regulator_TseB

1

IPR054945

54,945

NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit alpha

sulfhyd_HydA

Family

39

true

false

This entry represents the alpha subunit of NADPH-dependent hydrogenase/sulfhydrogenase 1, also known as sulfhydrogenase 1 subunit alpha. This protein is part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity. It may play a role in hydrogen ...

[]

0

[ "NCBIFAM" ]

[ "NF040832" ]

[ "sulfhyd_HydA" ]

[ 39 ]

1

[]

0

[ "5yxy", "5yy0", "9e15", "9e1j", "9nez", "9nf0" ]

6

[ "PUB00033242", "PUB00106003", "PUB00106004" ]

[ "7704275", "11265463", "11054105" ]

[ "Characterization of the locus encoding the [Ni-Fe] sulfhydrogenase from the archaeon Pyrococcus furiosus: evidence for a relationship to bacterial sulfite reductases.", "Hydrogenases I and II from Pyrococcus furiosus.", "Enzymes of hydrogen metabolism in Pyrococcus furiosus." ]

[ 1995, 2001, 2000 ]

3

[]

0

null

[ "Thermococcaceae" ]

[ 39 ]

1

[]

0

true

Family

NADPH-dependent hydrogenase/sulfhydrogenase 1 subunit alpha

sulfhyd_HydA

4

IPR054946

54,946

Pantoate kinase Mhun_0831

Mhun_0831

Family

38

true

This entry represents Pantoate kinase found in Methanospirillum hungatei JF-1. Pantoate kinase (PoK) is an enzyme that belongs to the GHMP kinase family, specifically the PoK subfamily. It is responsible for phosphorylating (R)-pantoate to form (R)-4-phosphopantoate, a crucial step in the coenzyme A (CoA) biosynthesis ...

[]

0

[ "NCBIFAM" ]

[ "NF040725" ]

[ "Panto_kinase" ]

[ 38 ]

1

[]

0

[]

0

[ "PUB00060435", "PUB00105931" ]

[ "19666462", "23200110" ]

[ "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.", "Identification of pantoate kinase and phosphopantothenate synthetase from Methanospirillum hungatei." ]

[ 2009, 2013 ]

2

[ "IPR012043" ]

[]

1

0

1

[ "Methanomicrobiales" ]

[ 38 ]

1

[]

0

true

Family

Pantoate kinase Mhun_0831

Mhun_0831

6

IPR054947

54,947

Glucose import system permease protein GlcT

GlcT_permease

Family

45

true

false

This entry represents the glucose import system permease protein GlcT, which is part of the ABC transporter complex GlcSTUV involved in glucose uptake. The protein is responsible for the translocation of glucose across the membrane. It belongs to the binding-protein-dependent transport system permease family. The prote...

[]

0

[ "NCBIFAM" ]

[ "NF040931" ]

[ "GlcT_permease" ]

[ 45 ]

1

[]

0

[]

0

[ "PUB00013790", "PUB00106073" ]

[ "11260467", "10400586" ]

[ "Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters.", "Glucose transport in the extremely thermoacidophilic Sulfolobus solfataricus involves a high-affinity membrane-integrated binding protein." ]

[ 2001, 1999 ]

2

[]

0

null

[ "Archaea" ]

[ 45 ]

1

[]

0

true

Family

Glucose import system permease protein GlcT

GlcT_permease

9

IPR054948

54,948

alpha-IPM synthase

IPMS

Family

56

true

false

2-isopropylmalate synthase (IPMS) is an enzyme that catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). This reaction represents the first step in the leucine biosynthesis pathway. Members of thi...

[]

0

[ "NCBIFAM" ]

[ "NF041069" ]

[ "IPMS" ]

[ 56 ]

1

[ "EC", "METACYC" ]

[ "2.3.3.13", "PWY-6871" ]

[ "EC:2.3.3.13", "METACYC:PWY-6871" ]

2

[]

0

[ "PUB00106155" ]

[ "31330039" ]

[ "Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius." ]

[ 2020 ]

1

[]

0

null

[ "Thermoproteati" ]

[ 56 ]

1

[]

0

true

Family

alpha-IPM synthase

IPMS

5

IPR054949

54,949

HTH-type transcriptional regulator CatM

HTH_CatM

Family

50

true

false

The HTH-type transcriptional regulator CatM is a protein found in Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). It positively regulates the expression of catA, catBCIJFD, and benPK in response to cis,cis-muconate. CatM binds to the catB-catM intercistronic region, a specific sequence upstream of catA, and th...

[]

0

[ "NCBIFAM" ]

[ "NF040710" ]

[ "HTH_CatM" ]

[ 50 ]

1

[]

0

[ "2h98" ]

1

[ "PUB00047583", "PUB00105920", "PUB00105922" ]

[ "19400783", "16517618", "14684899" ]

[ "Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1.", "CatM regulation of the benABCDE operon: functional divergence of two LysR-type paralogs in Acinetobacter baylyi ADP1.", "Crystallization of the effector-binding domains of BenM and CatM, LysR-type transcriptiona...

[ 2009, 2006, 2004 ]

3

[]

0

null

[ "Acinetobacter" ]

[ 50 ]

1

[]

0

true

Family

HTH-type transcriptional regulator CatM

HTH_CatM

1

IPR054950

54,950

Methane monooxygenase component C

MethMoxCompC

Family

49

true

false

Methane monooxygenase component C (mmoC) from Methylococcus capsulatus is responsible for the initial oxygenation of methane to methanol in methanotrophs. This enzyme also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic, and heterocyclic compounds. The component C is the iron-su...

[]

0

[ "NCBIFAM" ]

[ "NF045803" ]

[ "MethMoxCompC" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00001791", "PUB00154631", "PUB00154633" ]

[ "2205538", "1845980", "1785954" ]

[ "The methane monooxygenase gene cluster of Methylococcus capsulatus (Bath).", "Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. Identification of sites of component interaction.", "The methane monooxygenase gene cluster of Methylosinus trichosporium...

[ 1990, 1991, 1991 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 49 ]

1

[]

0

true

Family

Methane monooxygenase component C

MethMoxCompC

1

IPR054951

54,951

Cell division protein CdvC

cell_div_CdvC

Family

48

true

false

Cell division protein CdvC is a member of the AAA ATPase family and is involved in the cell division machinery of Sulfolobus acidocaldarius. The CdvA, CdvB, and CdvC proteins polymerize between segregating nucleoids and persist throughout cell division, forming a successively smaller structure during constriction. The ...

[]

0

[ "NCBIFAM" ]

[ "NF041006" ]

[ "cell_div_CdvC" ]

[ 48 ]

1

[]

0

[ "4lcb" ]

1

[ "PUB00050019", "PUB00083231" ]

[ "19008417", "18987308" ]

[ "A role for the ESCRT system in cell division in archaea.", "A unique cell division machinery in the Archaea." ]

[ 2008, 2008 ]

2

[]

0

null

[ "Thermoprotei" ]

[ 48 ]

1

[]

0

true

Family

Cell division protein CdvC

cell_div_CdvC

6

IPR054952

54,952

Oxalate oxidoreductase subunit beta

OxalOxred_beta

Family

37

true

false

Oxalate oxidoreductase subunit beta is an enzyme that catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. This enzyme does not require coenzyme A as a cosubstrate and enables anaerobic growth on oxalate, whi...

[]

0

[ "NCBIFAM" ]

[ "NF045792" ]

[ "OxalOxred_beta" ]

[ 37 ]

1

[]

0

[ "5c4i", "5exd", "5exe" ]

3

[ "PUB00078738" ]

[ "20956531" ]

[ "Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria" ]

[ 37 ]

1

[]

0

true

Family

Oxalate oxidoreductase subunit beta

OxalOxred_beta

9

IPR054953

54,953

Methane monooxygenase component A gamma chain

MethMoxGammaMmoZ

Family

43

true

false

Methane monooxygenase (MMO) is an enzyme complex found in methanotrophic bacteria that catalyzes the initial oxygenation of methane to methanol. The gamma chain of the methane monooxygenase component A, also known as mmoZ, plays a crucial role in this process. This subunit is responsible for the monohydroxylation of a ...

[]

0

[ "NCBIFAM" ]

[ "NF045805" ]

[ "MethMoxGammaMmoZ" ]

[ 43 ]

1

[]

0

[ "1fyz", "1fz0", "1fz1", "1fz2", "1fz3", "1fz4", "1fz5", "1fz6", "1fz7", "1fz8", "1fz9", "1fzh", "1fzi", "1mhy", "1mhz", "1mmo", "1mty", "1xmf", "1xmg", "1xmh", "1xu3", "1xu5", "1xvb", "1xvc", "1xvd", "1xve", "1xvf", "1xvg", "4gam", "6d7k", "6vk4", "6vk5"...

50

[ "PUB00019847", "PUB00154630", "PUB00154631", "PUB00154632" ]

[ "8255292", "2505721", "1845980", "1904125" ]

[ "Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane.", "Molecular analysis of methane monooxygenase from Methylococcus capsulatus (Bath).", "Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. ...

[ 1993, 1989, 1991, 1991 ]

4

[]

0

null

[ "Pseudomonadota" ]

[ 43 ]

1

[]

0

true

Family

Methane monooxygenase component A gamma chain

MethMoxGammaMmoZ

1

IPR054954

54,954

Carbonic anhydrase, gamma-class

carb_anhyd

Family

32

true

false

Carbonic anhydrases (CAs) are enzymes that catalyze the reversible hydration of carbon dioxide. This entry represents the gamma-class carbonic anhydrase family, which includes enzymes that are important for growth on acetate. In Methanosarcina thermophila, the carbonic anhydrase (MSTHT_0588) is likely an extracellular ...

[]

0

[ "NCBIFAM" ]

[ "NF040597" ]

[ "carb_anhyd" ]

[ 32 ]

1

[]

0

[ "1qq0", "1qre", "1qrf", "1qrg", "1qrl", "1qrm", "1thj", "3otm", "3otz", "3ou9", "3oup", "3ow5", "9lin" ]

13

[ "PUB00105846" ]

[ "8041719" ]

[ "A carbonic anhydrase from the archaeon Methanosarcina thermophila." ]

[ 1994 ]

1

[]

0

null

[ "Methanosarcinaceae", "bioreactor metagenome" ]

[ 31, 1 ]

2

[]

0

true

Family

Carbonic anhydrase, gamma-class

carb_anhyd

4

IPR054955

54,955

Methane monooxygenase regulatory protein B

MethMoxRegMmoB

Family

42

true

false

Methane monooxygenase regulatory protein B (MmoB) is a component of the soluble methane monooxygenase (sMMO) complex found in methanotrophic bacteria such as Methylosinus trichosporium and Methylococcus capsulatus. The MmoB protein acts as a regulator of electron flow through the sMMO complex, switching the enzyme from...

[]

0

[ "NCBIFAM" ]

[ "NF045804" ]

[ "MethMoxRegMmoB" ]

[ 42 ]

1

[]

0

[ "1ckv", "2mob", "4gam", "6vk4", "6vk5", "6vk8", "6yd0", "6ydi", "6ydu", "6yy3", "7m8q", "7m8r", "7s6q", "7s6r", "7s6s", "7s6t", "7s7h", "8xiw" ]

18

[ "PUB00154630", "PUB00154631", "PUB00154632", "PUB00154634" ]

[ "2505721", "1845980", "1904125", "10381404" ]

[ "Molecular analysis of methane monooxygenase from Methylococcus capsulatus (Bath).", "Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. Identification of sites of component interaction.", "Molecular analysis of the methane monooxygenase (MMO) gene cl...

[ 1989, 1991, 1991, 1999 ]

4

[]

0

null

[ "Pseudomonadota" ]

[ 42 ]

1

[]

0

true

Family

Methane monooxygenase regulatory protein B

MethMoxRegMmoB

4

IPR054956

54,956

Methane monooxygenase component A beta chain

MethMoxA_beta

Family

45

true

false

Methane monooxygenase component A beta chain is responsible for the initial oxygenation of methane to methanol in methanotrophs. This enzyme also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic, and heterocyclic compounds. The enzyme is found in species such as Methylosinus tric...

[]

0

[ "NCBIFAM" ]

[ "NF045802" ]

[ "MethMoxA_beta" ]

[ 45 ]

1

[]

0

[ "1fyz", "1fz0", "1fz1", "1fz2", "1fz3", "1fz4", "1fz5", "1fz6", "1fz7", "1fz8", "1fz9", "1fzh", "1fzi", "1mhy", "1mhz", "1mmo", "1mty", "1xmf", "1xmg", "1xmh", "1xu3", "1xu5", "1xvb", "1xvc", "1xvd", "1xve", "1xvf", "1xvg", "4gam", "6d7k", "6vk4", "6vk5"...

50

[ "PUB00019847", "PUB00154630", "PUB00154631", "PUB00154632" ]

[ "8255292", "2505721", "1845980", "1904125" ]

[ "Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane.", "Molecular analysis of methane monooxygenase from Methylococcus capsulatus (Bath).", "Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. ...

[ 1993, 1989, 1991, 1991 ]

4

[]

0

null

[ "Plasmodium yoelii yoelii", "Pseudomonadota" ]

[ 1, 44 ]

2

[]

0

true

Family

Methane monooxygenase component A beta chain

MethMoxA_beta

2

IPR054957

54,957

Phospho-furanose lactonase

PhFuoseLconase

Family

50

true

false

Phospho-furanose lactonase catalyzes the hydrolysis of D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. It is also capable of hydrolyzing carboxy 1,4-lactones. This enzyme belongs to the metallo-dependent hydrolases superfamily, specifically the phosphotriesterase family. The enzyme is found in M...

[]

0

[ "NCBIFAM" ]

[ "NF045706" ]

[ "PhFuoseLconase" ]

[ 50 ]

1

[]

0

[ "3msr", "3ovg" ]

2

[ "PUB00085013" ]

[ "24955762" ]

[ "Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate." ]

[ 2014 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 50 ]

1

[]

0

true

Family

Phospho-furanose lactonase

PhFuoseLconase

6

IPR054958

54,958

NurA family nuclease

NurA_nuclease

Family

30

true

false

The DNA double-strand break repair nuclease NurA is involved in the repair of DNA double-strand breaks (DSBs). It likely acts in conjunction with HerA to stimulate the resection of the 5' strand, producing the long 3' single-strand required for RadA loading. NurA exhibits 5' endonuclease activity as well as both 5' and...

[]

0

[ "NCBIFAM" ]

[ "NF041032" ]

[ "NurA_nuclease" ]

[ 30 ]

1

[]

0

[ "3tai", "3tal", "3taz" ]

3

[ "PUB00105991", "PUB00106139" ]

[ "18957200", "22064858" ]

[ "The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break.", "Crystal structure of the NurA-dAMP-Mn2+ complex." ]

[ 2008, 2012 ]

2

[]

0

null

[ "Methanobacteriota" ]

[ 30 ]

1

[]

0

true

Family

NurA family nuclease

NurA_nuclease

7

IPR054959

54,959

Sarcosine reductase complex component B subunit beta

Sarcosine_GrdF

Family

39

true

false

Sarcosine reductase complex component B subunit beta is involved in the first step of sarcosine reductase. The substrate is bound to component PB via a Schiff base intermediate. The PB-activated substrate is then nucleophilically attacked by the selenol anion of component PA, transforming it into a carboxymethylated se...

[]

0

[ "NCBIFAM" ]

[ "NF040794" ]

[ "Sarcosine_GrdF" ]

[ 39 ]

1

[]

0

[]

0

[ "PUB00105967" ]

[ "24926057" ]

[ "Complete Genome Sequence of Amino Acid-Utilizing Eubacterium acidaminophilum al-2 (DSM 3953)." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria" ]

[ 39 ]

1

[]

0

true

Family

Sarcosine reductase complex component B subunit beta

Sarcosine_GrdF

8

IPR054961

54,961

MPN499 protein

MPN499

Family

62

true

This entry represents the MPN499 family protein, which is currently uncharacteriσed. The protein is found in Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) and is encoded by the MPN_499 gene. The specific function of this protein family remains unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045754", "PF26924" ]

[ "MPN499", "MPN_499" ]

[ 51, 62 ]

2

[]

0

[]

0

[ "PUB00154763" ]

[ "22373819" ]

[ "Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium." ]

[ 2012 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 62 ]

1

[]

0

true

Family

MPN499 protein

MPN499

3

IPR054963

54,963

Trehalase 2

Trehalase_2

Family

35

true

false

Trehalase 2 is an enzyme that catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose. It belongs to the glycosyl hydrolase 15 family and is found in Sulfolobus acidocaldarius. This enzyme plays a crucial role in carbohydrate metabolism by breaking down trehalose, a disaccharide sugar. The act...

[]

0

[ "NCBIFAM" ]

[ "NF041085" ]

[ "Trehalase_2" ]

[ 35 ]

1

[]

0

[]

0

[ "PUB00106167" ]

[ "29574614" ]

[ "Two trehalose-hydrolyzing enzymes from Crenarchaeon Sulfolobus acidocaldarius exhibit distinct activities and affinities toward trehalose." ]

[ 2018 ]

1

[]

0

null

[ "Sulfolobaceae" ]

[ 35 ]

1

[]

0

true

Family

Trehalase 2

Trehalase_2

3

IPR054964

54,964

Preflagellin peptidase

Arch_preflagellin_pept

Family

35

true

false

Preflagellin peptidases, also known as FlaK, are enzymes that cleave the N-terminal leader peptide from preflagellins. This processing is necessary for the assembly of flagellins into a flagellum structure. These enzymes belong to the peptidase A24 family, specifically the archaeal preflagellin peptidase subfamily. The...

[]

0

[ "NCBIFAM" ]

[ "NF040695" ]

[ "Arch_preflagellin_pept" ]

[ 35 ]

1

[ "EC" ]

[ "3.4.23.52" ]

[ "EC:3.4.23.52" ]

1

[ "3s0x" ]

1

[ "PUB00010516", "PUB00066803" ]

[ "11934494", "21765428" ]

[ "FlaK of the archaeon Methanococcus maripaludis possesses preflagellin peptidase activity.", "The crystal structure of GXGD membrane protease FlaK." ]

[ 2002, 2011 ]

2

[]

0

null

[ "Methanococcales" ]

[ 35 ]

1

[]

0

true

Family

Preflagellin peptidase

Arch_preflagellin_pept

5

IPR054965

54,965

HTH-type sugar sensing transcriptional regulator TrmB

tran_reg_TrmB

Family

22

true

false

The HTH-type sugar sensing transcriptional regulator TrmB is a protein family involved in the regulation of sugar metabolism in archaea. Members of this family, such as those found in Pyrococcus furiosus (Q9HGZ9) and Thermococcus litoralis (Q7LYW4), contain an N-terminal DNA-binding domain and a C-terminal sugar-bindin...

[]

0

[ "NCBIFAM" ]

[ "NF040851" ]

[ "tran_reg_TrmB" ]

[ 22 ]

1

[]

0

[ "3qph" ]

1

[ "PUB00015607", "PUB00060975", "PUB00106022" ]

[ "12426307", "16135241", "17504272" ]

[ "TrmB, a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter from the hyperthermophilic archaeon Thermococcus litoralis.", "TrmB, a sugar sensing regulator of ABC transporter genes in Pyrococcus furiosus exhibits dual promoter specificity and is controlled by different inducers.", ...

[ 2003, 2005, 2007 ]

3

[]

0

null

[ "Thermococcaceae" ]

[ 22 ]

1

[]

0

true

Family

HTH-type sugar sensing transcriptional regulator TrmB

tran_reg_TrmB

3

IPR054966

54,966

4-epi-cubebol synthase

epi-cubol_syn

Family

58

true

false

4-epi-cubebol synthase is an enzyme that belongs to the terpene synthase family. It catalyses the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpenol 4-epi-cubebol via a 1,10-cyclization. This process requires the abstraction of the pyrophosphate from FPP to yield a (E,E)-germacradieny...

[]

0

[ "NCBIFAM" ]

[ "NF042951" ]

[ "epi-cubol_syn" ]

[ 58 ]

1

[]

0

[]

0

[ "PUB00151349", "PUB00151350" ]

[ "27829890", "27666571" ]

[ "Mechanistic investigations on six bacterial terpene cyclases.", "Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations." ]

[ 2016, 2016 ]

2

[]

0

null

[ "Streptosporangiaceae" ]

[ 58 ]

1

[]

0

true

Family

4-epi-cubebol synthase

epi-cubol_syn

9

IPR054968

54,968

1-deoxy-11-beta-hydroxypentalenate dehydrogenase

HdxpentlteDhPtlF

Family

30

true

false

This entry represents 1-deoxy-11-beta-hydroxypentalenate dehydrogenase, an enzyme involved in the biosynthesis of pentalenolactone antibiotics. The enzyme catalyzes the oxidation of 1-deoxy-11-beta-hydroxypentalenic acid to 1-deoxy-11-oxopentalenic acid. Members of this family belong to the short-chain dehydrogenases/r...

[]

0

[ "NCBIFAM" ]

[ "NF045814" ]

[ "HdxpentlteDhPtlF" ]

[ 30 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.1.1.340", "PWY-6915", "PWY-6919" ]

[ "EC:1.1.1.340", "METACYC:PWY-6915", "METACYC:PWY-6919" ]

3

[]

0

[ "PUB00154689", "PUB00154691", "PUB00154693" ]

[ "21284395", "21250661", "17178094" ]

[ "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.", "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in t...

[ 2011, 2011, 2007 ]

3

[]

0

null

[ "Actinomycetes" ]

[ 30 ]

1

[]

0

true

Family

1-deoxy-11-beta-hydroxypentalenate dehydrogenase

HdxpentlteDhPtlF

4

IPR054969

54,969

Pentalenene synthase

PentlnSyn

Family

29

true

false

Pentalenene synthase is an enzyme that catalyzes the cyclization of farnesyl diphosphate (FPP) to the tricyclic sesquiterpene pentalenene. This reaction is a key step in the biosynthesis of the pentalenolactone family of antibiotics, which are produced by various Streptomyces species. The enzyme belongs to the terpene ...

[]

0

[ "NCBIFAM" ]

[ "NF045811" ]

[ "PentlnSyn" ]

[ 29 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.2.3.7", "PWY-6915", "PWY-6919" ]

[ "EC:4.2.3.7", "METACYC:PWY-6915", "METACYC:PWY-6919" ]

3

[ "1hm4", "1hm7", "1ps1", "6wkc", "6wkd", "6wke", "6wkf", "6wkg", "6wkh", "6wki", "6wkj", "9c7k", "9c7l", "9c7m" ]

14

[ "PUB00022455", "PUB00154688", "PUB00154689", "PUB00154690" ]

[ "9295272", "16681390", "21284395", "8180213" ]

[ "Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.", "A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis.", "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidat...

[ 1997, 2006, 2011, 1994 ]

4

[ "IPR034686" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 29 ]

1

[]

0

true

Family

Pentalenene synthase

PentlnSyn

7

IPR054970

54,970

Alpha-L-rhamnosidase, ulvan degradation

Rhamnosidase_Flavobac

Family

40

true

false

Alpha-L-rhamnosidase is an enzyme that may be involved in the degradation of ulvan, the main polysaccharide component of the cell wall of Ulvales (green seaweed). Ulvan is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xyl...

[]

0

[ "NCBIFAM" ]

[ "NF041572" ]

[ "Rhamnosidase_Flavobac" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00093668" ]

[ "31285597" ]

[ "A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan." ]

[ 2019 ]

1

[]

0

null

[ "Flavobacteriaceae" ]

[ 40 ]

1

[]

0

true

Family

Alpha-L-rhamnosidase, ulvan degradation

Rhamnosidase_Flavobac

6

IPR054971

54,971

1-deoxypentalenic acid 11-beta-hydroxylase

DxPntBtaHylase

Family

30

true

false

1-deoxypentalenic acid 11-beta-hydroxylase is an enzyme that catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid. This reaction is a key step in the biosynthesis of the antibiotic pentalenolactone. The enzyme belongs to the PhyH family and is found in various Streptomyces specie...

[]

0

[ "NCBIFAM" ]

[ "NF045813" ]

[ "DxPntBtaHylase" ]

[ 30 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.14.11.35", "PWY-6915", "PWY-6919" ]

[ "EC:1.14.11.35", "METACYC:PWY-6915", "METACYC:PWY-6919" ]

3

[ "2rdn", "2rdq", "2rdr", "2rds" ]

4

[ "PUB00154689", "PUB00154691", "PUB00154692" ]

[ "21284395", "21250661", "16704250" ]

[ "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.", "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in t...

[ 2011, 2011, 2006 ]

3

[]

0

null

[ "Actinomycetes" ]

[ 30 ]

1

[]

0

true

Family

1-deoxypentalenic acid 11-beta-hydroxylase

DxPntBtaHylase

2

IPR054973

54,973

Pentalenolactone F synthase

PentlctneF_syn

Family

29

true

false

This entry represents pentalenolactone F synthase, an enzyme that catalyzes the Fe(2+) and alpha-ketoglutarate-dependent oxidation of pentalenolactone D to pentalenolactone F. This enzyme is involved in the biosynthesis of the pentalenolactone antibiotic. Additionally, it can catalyze the oxidation of pentalenolactone ...

[]

0

[ "NCBIFAM" ]

[ "NF045815" ]

[ "PentlctneF_syn" ]

[ 29 ]

1

[ "EC" ]

[ "1.14.11.36" ]

[ "EC:1.14.11.36" ]

1

[]

0

[ "PUB00154689", "PUB00154691" ]

[ "21284395", "21250661" ]

[ "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.", "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in t...

[ 2011, 2011 ]

2

[]

0

null

[ "Actinomycetes" ]

[ 29 ]

1

[]

0

true

Family

Pentalenolactone F synthase

PentlctneF_syn

7

IPR054974

54,974

Pectinesterase B

Pectinest_B

Family

50

true

false

Pectinesterase B (PemB) is an enzyme that belongs to the pectinesterase family. It is involved in the degradation of methylated oligogalacturonides present in the periplasm. This enzyme is more active on methylated oligogalacturides than on pectin. Pectinesterase B is found in bacteria such as Dickeya dadantii (strain ...

[]

0

[ "NCBIFAM" ]

[ "NF041901" ]

[ "Pectinest_B" ]

[ 50 ]

1

[]

0

[]

0

[ "PUB00152933" ]

[ "8830237" ]

[ "Characterization of pectin methylesterase B, an outer membrane lipoprotein of Erwinia chrysanthemi 3937." ]

[ 1996 ]

1

[]

0

null

[ "Enterobacterales" ]

[ 50 ]

1

[]

0

true

Family

Pectinesterase B

Pectinest_B

4

IPR054976

54,976

Pentalenolactone synthase

PentlenlactSyn

Family

24

true

false

Pentalenolactone synthase is an enzyme that catalyzes the final step in the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone. This enzyme mediates the oxidative rearrangement of pentalenolactone F to pentalenolactone. It belongs to the cytochrome P450 family, which is known for its role in the oxidative ...

[]

0

[ "NCBIFAM" ]

[ "NF045816" ]

[ "PentlenlactSyn" ]

[ 24 ]

1

[]

0

[ "5l1o", "5l1p", "5l1q", "5l1r", "5l1s", "5l1t", "5l1u", "5l1v", "5l1w" ]

9

[ "PUB00154689" ]

[ "21284395" ]

[ "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone." ]

[ 2011 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 24 ]

1

[]

0

true

Family

Pentalenolactone synthase

PentlenlactSyn

2

IPR054977

54,977

Uncharacterized protein CT_504-like

CT_504-like

Family

47

false

This entry represents several uncharacterised proteins such as CT_504 from Chlamydia trachomatis, TC_0791 from Chlamydia muridarum and CPn_0623 from Chlamydia pneumoniae, and related proteins from Chlamydiaceae lineage.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045799", "PF28261" ]

[ "GrgA", "GrgA_tf" ]

[ 31, 47 ]

2

[]

0

[]

0

[ "PUB00154808", "PUB00154809", "PUB00154810", "PUB00154811", "PUB00154812" ]

[ "33940135", "38112466", "34342542", "30061357", "23027952" ]

[ "GrgA overexpression inhibits Chlamydia trachomatis growth through sigma66- and sigma28-dependent mechanisms.", "Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance.", "Identification of a GrgA-Euo-HrcA Transcriptional R...

[ 2021, 2024, 2021, 2018, 2012 ]

5

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 46, 1 ]

2

[]

0

true

Family

Uncharacterized protein CT_504-like

CT_504-like

3

IPR054978

54,978

Endo-beta-N-acetylglucosaminidase F3

Endoglyc_F3

Family

21

true

false

Endo-beta-N-acetylglucosaminidase F3 (Endo F3) is an enzyme that catalyzes the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins. It is capable of hydrolyzing bi- and triantennary glycans. The presence of a core-bound fucose significantly enhances Endo F3 activity on bian...

[]

0

[ "NCBIFAM" ]

[ "NF045481" ]

[ "Endoglyc_F3" ]

[ 21 ]

1

[]

0

[ "1eok", "1eom" ]

2

[ "PUB00153667", "PUB00153668" ]

[ "7768917", "7768916" ]

[ "Detailed structural analysis of a novel, specific O-linked glycan from the prokaryote Flavobacterium meningosepticum.", "Novel, specific O-glycosylation of secreted Flavobacterium meningosepticum proteins. Asp-Ser and Asp-Thr-Thr consensus sites." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Bacteroidota" ]

[ 21 ]

1

[]

0

true

Family

Endo-beta-N-acetylglucosaminidase F3

Endoglyc_F3

6

IPR054979

54,979

Uncharacterized protein MG241/MG241-like

MG241/MG241-like

Family

45

true

This entry represents the uncharacterised proteins MG241 and MG242 from Mycoplasma genitalium and their homologues from Mycoplasma pneumoniae. The exact function of these proteins is currently unknown.

[]

0

[ "NCBIFAM", "NCBIFAM", "PFAM" ]

[ "NF045749", "NF045750", "PF28262" ]

[ "MPN337", "MPN338_fam_protein", "MPN337" ]

[ 23, 28, 45 ]

3

[]

0

[]

0

[ "PUB00154763", "PUB00154765" ]

[ "22373819", "32732422" ]

[ "Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.", "In-cell architecture of an actively transcribing-translating expressome." ]

[ 2012, 2020 ]

2

[]

0

null

[ "Mycoplasmatota" ]

[ 45 ]

1

[]

0

true

Family

Uncharacterized protein MG241/MG241-like

MG241/MG241-like

9

IPR054980

54,980

Nine-heme cytochrome c

9HemeCytC

Family

15

true

false

Nine-heme cytochrome c proteins are characterized by the presence of nine heme groups arranged into two tetraheme clusters, with an additional heme located asymmetrically between the two regions. These proteins may form part of a transmembrane redox complex, facilitating electron transfer to the cytoplasm for the reduc...

[]

0

[ "NCBIFAM" ]

[ "NF045784" ]

[ "9HemeCytC" ]

[ 15 ]

1

[]

0

[]

0

[ "PUB00023222", "PUB00154813" ]

[ "10368280", "10471375" ]

[ "The primary and three-dimensional structures of a nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774 reveal a new member of the Hmc family.", "Sequencing the gene encoding desulfovibrio desulfuricans ATCC 27774 nine-heme cytochrome c." ]

[ 1999, 1999 ]

2

[]

0

null

[ "Desulfovibrio" ]

[ 15 ]

1

[]

0

true

Family

Nine-heme cytochrome c

9HemeCytC

7

IPR054981

54,981

Indoleacetate decarboxylase activating enzyme

Ind_deCO2_activ

Family

14

true

false

This entry represents the indoleacetate decarboxylase activating enzyme. This enzyme catalyzes the activation of indoleacetate decarboxylase under anaerobic conditions by generating an organic free radical on a glycine residue through the homolytic cleavage of S-adenosyl-L-methionine (SAM). The enzyme belongs to the or...

[]

0

[ "NCBIFAM" ]

[ "NF033719" ]

[ "Ind_deCO2_activ" ]

[ 14 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 14 ]

1

[]

0

true

Family

Indoleacetate decarboxylase activating enzyme

Ind_deCO2_activ

1

IPR054982

54,982

Chondroitinase-AC

ChondaseAC

Family

14

true

false

Chondroitinase-AC, also known as chondroitinase AC, is an enzyme that belongs to the polysaccharide lyase 8 family. This enzyme is involved in the degradation of chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix of animal tissues. Chondroitinase-AC specifically cleaves the glycosidic bonds in c...

[]

0

[ "NCBIFAM" ]

[ "NF043001" ]

[ "ChondaseAC" ]

[ 14 ]

1

[]

0

[ "1cb8", "1hm2", "1hm3", "1hmu", "1hmw" ]

5

[ "PUB00010617", "PUB00153666" ]

[ "11327856", "10618199" ]

[ "Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.", "Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium...

[ 2001, 2000 ]

2

[]

0

null

[ "Bacteroidota" ]

[ 14 ]

1

[]

0

true

Family

Chondroitinase-AC

ChondaseAC

5

IPR054983

54,983

Iron transporter MagA

FeTrans_MagA

Family

12

true

false

Iron transporter MagA is a protein found in Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1). It plays a crucial role in the synthesis of bacterial magnetic particles (BMPs) by transporting iron from the environment into the cytoplasm across the cell membrane, and subsequently from the cytoplasm into the BM...

[]

0

[ "NCBIFAM" ]

[ "NF045626" ]

[ "FeTrans_MagA" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00154760", "PUB00154761" ]

[ "8537318", "7499342" ]

[ "Iron-regulated expression and membrane localization of the magA protein in Magnetospirillum sp. strain AMB-1.", "An iron-regulated gene, magA, encoding an iron transport protein of Magnetospirillum sp. strain AMB-1." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Rhodospirillales" ]

[ 12 ]

1

[]

0

true

Family

Iron transporter MagA

FeTrans_MagA

7

IPR054984

54,984

Digeranylgeranylglycerophospholipid reductase family

DGGPL_reductase

Family

10

true

false

Digeranylgeranylglycerophospholipid reductase is an enzyme involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. This enzyme catalyzes the formation of archaetidic acid ...

[]

0

[ "NCBIFAM" ]

[ "NF041160" ]

[ "DGGPL_reductase" ]

[ 10 ]

1

[ "EC", "METACYC" ]

[ "1.3.1.101", "PWY-6141" ]

[ "EC:1.3.1.101", "METACYC:PWY-6141" ]

2

[ "3oz2" ]

1

[ "PUB00054596", "PUB00106211" ]

[ "16788058", "20869368" ]

[ "Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.", "Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme i...

[ 2006, 2010 ]

2

[]

0

null

[ "Thermoplasmatales" ]

[ 10 ]

1

[]

0

true

Family

Digeranylgeranylglycerophospholipid reductase family

DGGPL_reductase

6

IPR054985

54,985

Hexaprenyl-diphosphate synthase large subunit

HxpDPsynlarge

Family

21

true

false

Hexaprenyl-diphosphate synthase large subunit catalyzes the condensation of three molecules of isopentenyl diphosphate with farnesyl diphosphate (FPP) to yield (all-E)-hexaprenyl diphosphate (HexPP; C30), the precursor of the prenyl side chain of menaquinone-6. The large subunit, Hexs-B, is responsible for the condensa...

[]

0

[ "NCBIFAM" ]

[ "NF045628" ]

[ "HxpDPsynlarge" ]

[ 21 ]

1

[]

0

[ "3aqb", "3aqc" ]

2

[ "PUB00057665", "PUB00154814" ]

[ "21068379", "9515931" ]

[ "Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation.", "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Microc...

[ 2011, 1998 ]

2

[]

0

null

[ "Bacillati" ]

[ 21 ]

1

[]

0

true

Family

Hexaprenyl-diphosphate synthase large subunit

HxpDPsynlarge

5

IPR054987

54,987

3(1)-hydroxy-L-isoleucine 4-dioxygenase

Il_dioxgen_HilB

Family

19

true

false

This entry represents the enzyme 3(1)-hydroxy-L-isoleucine 4-dioxygenase, also known as HilB, from Pantoea ananatis (strain AJ13355). HilB belongs to the iron/ascorbate-dependent oxidoreductase family and catalyzes the hydroxylation of L-4'-hydroxyisoleucine (4'-HIL) at the C-4 position to form L-4,4'-dihydroxyisoleuci...

[]

0

[ "NCBIFAM" ]

[ "NF042428" ]

[ "Il_dioxgen_HilB" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00100360", "PUB00109260" ]

[ "23554367", "22448874" ]

[ "A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis.", "A novel family of bacterial dioxygenases that catalyse the hydroxylation of free L-amino acids." ]

[ 2013, 2012 ]

2

[]

0

null

[ "Enterobacterales" ]

[ 19 ]

1

[]

0

true

Family

3(1)-hydroxy-L-isoleucine 4-dioxygenase

Il_dioxgen_HilB

4

IPR054988

54,988

Aldehyde dehydrogenase AldH

AldDh_AldH

Family

16

true

false

This entry represents aldehyde dehydrogenase (AldH) proteins, which belong to the aldehyde dehydrogenase family. These enzymes are capable of oxidizing various aldehydes such as formaldehyde, glyceraldehyde, butyraldehyde, glutaraldehyde, and benzaldehyde in vitro. They are likely involved in the oxidative D-xylose deg...

[]

0

[ "NCBIFAM" ]

[ "NF042989" ]

[ "AldDh_AldH" ]

[ 16 ]

1

[]

0

[]

0

[ "PUB00095194" ]

[ "23063486" ]

[ "Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1." ]

[ 2013 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 16 ]

1

[]

0

true

Family

Aldehyde dehydrogenase AldH

AldDh_AldH

7

IPR054989

54,989

MG267/MG319-like

Family

22

false

This entry represents a group of unchareacterised proteins for Mycoplasmatota, including MG267 and MG319 from Mycoplasma genitalium and its homologues from Mycoplasma pneumoniae. The exact function of these proteins is currently unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045771", "PF28263" ]

[ "MPN454_MG319", "MPN454_MG319" ]

[ 22, 22 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 22 ]

1

[]

0

true

Family

MG267/MG319-like

6

IPR054990

54,990

DNA double-strand break repair ATPase Rad50

Rad50_ATPase_DNA_repair

Family

14

true

false

The DNA double-strand break repair ATPase Rad50 is a crucial component of the Rad50/Mre11 complex, which plays a significant role in the early stages of DNA double-strand break (DSB) repair. This complex is thought to facilitate the opening of processed DNA ends, aiding in the recruitment of other proteins such as HerA...

[]

0

[ "NCBIFAM" ]

[ "NF041034" ]

[ "Rad50_ATPase_DNA_repair" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00106138" ]

[ "18294364" ]

[ "The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius." ]

[ 2008 ]

1

[]

0

null

[ "Sulfolobaceae" ]

[ 14 ]

1

[]

0

true

Family

DNA double-strand break repair ATPase Rad50

Rad50_ATPase_DNA_repair

6

IPR054991

54,991

Cyclohexane-1-carbonyl-CoA dehydrogenase

CyhCrbnylCoADH

Family

8

true

false

Cyclohexane-1-carbonyl-CoA dehydrogenase is an enzyme that belongs to the acyl-CoA dehydrogenase family. This enzyme is involved in the anaerobic degradation of cyclohexane carboxylic acid (CHC). It catalyzes the 1,2-dehydrogenation of cyclohexane-1-carbonyl-CoA (CHCoA) to cyclohex-1-ene-1-carbonyl-CoA (CHeneCoA). In G...

[]

0

[ "NCBIFAM" ]

[ "NF043006" ]

[ "CyhCrbnylCoADH" ]

[ 8 ]

1

[]

0

[]

0

[ "PUB00153596" ]

[ "23667239" ]

[ "Cyclohexanecarboxyl-coenzyme A (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus." ]

[ 2013 ]

1

[]

0

null

[ "Thermodesulfobacteriota" ]

[ 8 ]

1

[]

0

true

Family

Cyclohexane-1-carbonyl-CoA dehydrogenase

CyhCrbnylCoADH

1

IPR054992

54,992

46 kDa surface antigen

SurfProtP46

Family

10

true

false

The 46 kDa surface antigen (P46) is a protein found in Mesomycoplasma hyopneumoniae, specifically in strains J (ATCC 25934 / NCTC 10110) and 232. This protein is implicated in the surface structure of the bacterium, potentially playing a role in host-pathogen interactions. The P46 protein is 416 amino acids in length a...

[]

0

[ "NCBIFAM" ]

[ "NF045705" ]

[ "SurfProtP46" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00154777", "PUB00154778" ]

[ "32355038", "7896725" ]

[ "Structure of P46, an immunodominant surface protein from Mycoplasma hyopneumoniae: interaction with a monoclonal antibody.", "Molecular cloning of a 46-kilodalton surface antigen (P46) gene from Mycoplasma hyopneumoniae: direct evidence of CGG codon usage for arginine." ]

[ 2020, 1995 ]

2

[]

0

null

[ "Mesomycoplasma" ]

[ 10 ]

1

[]

0

true

Family

46 kDa surface antigen

SurfProtP46

9

IPR054993

54,993

Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD

FolD_Thplmales

Family

10

true

false

This entry represents the bifunctional protein FolD, which belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. The FolD enzyme catalyzes two sequential reactions in the folate metabolism pathway: the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate, followed by the hydrolysi...

[]

0

[ "NCBIFAM" ]

[ "NF041156" ]

[ "FolD_Thplmales" ]

[ 10 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.5.1.5", "3.5.4.9", "PWY-1722", "PWY-2201", "PWY-3841", "PWY-5030", "PWY-5497", "PWY-6613", "PWY-7909", "PWY-8303" ]

[ "EC:1.5.1.5", "EC:3.5.4.9", "METACYC:PWY-1722", "METACYC:PWY-2201", "METACYC:PWY-3841", "METACYC:PWY-5030", "METACYC:PWY-5497", "METACYC:PWY-6613", "METACYC:PWY-7909", "METACYC:PWY-8303" ]

10

[ "3ngl", "3ngx" ]

2

[ "PUB00055732", "PUB00106207" ]

[ "21333632", "8436115" ]

[ "Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum.", "Cloning, sequencing and expression of the gene encoding glucose dehydrogenase from the thermophilic archaeon Thermoplasma acidophilum." ]

[ 2011, 1993 ]

2

[]

0

null

[ "Thermoplasmatales" ]

[ 10 ]

1

[]

0

true

Family

Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD

FolD_Thplmales

6

IPR054994

54,994

Dimethylsulfonioproprionate lyase DddY

DimsulpropLyDddY

Family

6

true

Dimethylsulfonioproprionate lyase DddY is an enzyme found in Alcaligenes faecalis that cleaves dimethylsulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. This enzyme plays a crucial role in the global sulfur cycle by faci...

[]

0

[ "NCBIFAM" ]

[ "NF043049" ]

[ "DimsulpropLyDddY" ]

[ 6 ]

1

[]

0

[ "5xkx", "5xky", "5y4k", "8hle" ]

4

[ "PUB00076456" ]

[ "21248856" ]

[ "DddY, a periplasmic dimethylsulfoniopropionate lyase found in taxonomically diverse species of Proteobacteria." ]

[ 2011 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 6 ]

1

[]

0

true

Family

Dimethylsulfonioproprionate lyase DddY

DimsulpropLyDddY

1

IPR054995

54,995

Esterase EstD

Esterase_EstD

Family

10

true

false

Esterase EstD from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) is a member of the AB hydrolase superfamily, specifically the Esterase 10 family. This enzyme exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological fu...

[]

0

[ "NCBIFAM" ]

[ "NF041096" ]

[ "Esterase_EstD" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00075373" ]

[ "17466017" ]

[ "Characterization and structural modeling of a new type of thermostable esterase from Thermotoga maritima." ]

[ 2007 ]

1

[]

0

null

[ "Thermotogales" ]

[ 10 ]

1

[]

0

true

Family

Esterase EstD

Esterase_EstD

3

IPR054996

54,996

Glycerate 2-kinase

Gly_kinase

Family

8

true

false

Glycerate 2-kinase (EC 2.7.1.165) catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. This enzyme belongs to the glycerate kinase type-1 family and is involved in the glycerate pathway. It can also partially utilize GTP, CTP, or UTP as phosphate donors. The enzyme is found in various organ...

[]

0

[ "NCBIFAM" ]

[ "NF040791" ]

[ "Gly_kinase" ]

[ 8 ]

1

[]

0

[]

0

[ "PUB00105964" ]

[ "16684110" ]

[ "Characterization of glycerate kinase (2-phosphoglycerate forming), a key enzyme of the nonphosphorylative Entner-Doudoroff pathway, from the thermoacidophilic euryarchaeon Picrophilus torridus." ]

[ 2006 ]

1

[]

0

null

[ "Thermoplasmatales" ]

[ 8 ]

1

[]

0

true

Family

Glycerate 2-kinase

Gly_kinase

4

IPR054997

54,997

Cytochrome c-554 Puf2C

Cyt554Puf2C

Family

9

true

false

Cytochrome c-554, encoded by the puf2C gene in Chloroflexus aurantiacus, serves as the immediate electron donor to the oxidized bacteriochlorophyll dimer (BChl2) during the initial step of light-induced charge separation. This protein can also oxidize low-potential substrates, playing a crucial role in the electron tra...

[]

0

[ "NCBIFAM" ]

[ "NF043009" ]

[ "Cyt554Puf2C" ]

[ 9 ]

1

[]

0

[ "8ydm" ]

1

[ "PUB00153489", "PUB00153490" ]

[ "1660302", "7535995" ]

[ "The primary structure of cytochrome c-554 from the green photosynthetic bacterium Chloroflexus aurantiacus.", "Cloning and sequencing of the genes encoding the light-harvesting B806-866 polypeptides and initial studies on the transcriptional organization of puf2B, puf2A and puf2C in Chloroflexus aurantiacus." ]

[ 1991, 1995 ]

2

[]

0

null

[ "Chloroflexineae" ]

[ 9 ]

1

[]

0

true

Family

Cytochrome c-554 Puf2C

Cyt554Puf2C

2

IPR054998

54,998

Nucleoside kinase

NucKin

Family

7

true

false

This entry represents nucleoside kinases, which belong to the carbohydrate kinase PfkB family. These enzymes catalyze the phosphorylation of various nucleosides to their corresponding nucleoside 5'-mono-phosphates in the presence of phosphate donors and divalent cations. The nucleoside kinase from Thermoplasma acidophi...

[]

0

[ "NCBIFAM" ]

[ "NF041164" ]

[ "NucKin" ]

[ 7 ]

1

[]

0

[ "3bf5" ]

1

[ "PUB00106214" ]

[ "23161756" ]

[ "A broad specificity nucleoside kinase from Thermoplasma acidophilum." ]

[ 2013 ]

1

[]

0

null

[ "Thermoplasmatales" ]

[ 7 ]

1

[]

0

true

Family

Nucleoside kinase

NucKin

2

IPR054999

54,999

Hexaprenyl-diphosphate synthase, small subunit

HexA

Family

9

false

This entry represents the small subunit of Hexaprenyl-diphosphate synthase (HexA) found in bacterial proteins. It is composed of mostly antiparallel α-helices joined by connecting loops [ ]. Hexaprenyl-diphosphate synthase from Micrococcus luteus is made of a small subunit (HexA) and a large subunit (HexB). HexA cataly...

[]

0

[ "NCBIFAM" ]

[ "NF045627" ]

[ "HxpDPsynsmall" ]

[ 9 ]

1

[]

0

[ "3aqb", "3aqc" ]

2

[ "PUB00057665", "PUB00154814" ]

[ "21068379", "9515931" ]

[ "Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation.", "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Microc...

[ 2011, 1998 ]

2

[]

0

null

[ "Bacillati" ]

[ 9 ]

1

[]

0

true

Family

Hexaprenyl-diphosphate synthase, small subunit

HexA

9

IPR055000

55,000

Uncharacterised protein MPN160 family

MPN160_family

Family

8

true

false

This entry represents a family of uncharacterised proteins, including the uncharacterised protein MG147 homolog from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) and the uncharacterised protein MG147 from Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37). The function of these pro...

[]

0

[ "NCBIFAM" ]

[ "NF045740" ]

[ "MPN160_family" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 8 ]

1

[]

0

true

Family

Uncharacterised protein MPN160 family

MPN160_family

2

IPR055001

55,001

L-2-amino-4-chloropent-4-enoate dechlorinase/desaturase

PAGG_Syn_BesB

Family

10

true

This entry represents the enzyme L-2-amino-4-chloropent-4-enoate dechlorinase/desaturase, also known as BesB, from Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057). This enzyme is involved in the biosynthesis of terminal alkyne-containing amino acids such as L-proparg...

[]

0

[ "NCBIFAM" ]

[ "NF042918" ]

[ "PAGG_Syn_BesB" ]

[ 10 ]

1

[]

0

[ "9aua", "9aub" ]

2

[ "PUB00093050" ]

[ "30867596" ]

[ "Discovery of a pathway for terminal-alkyne amino acid biosynthesis." ]

[ 2019 ]

1

[]

0

null

[ "Streptomycetaceae" ]

[ 10 ]

1

[]

0

true

Family

L-2-amino-4-chloropent-4-enoate dechlorinase/desaturase

PAGG_Syn_BesB

6

IPR055003

55,003

GLD-3, KH3 domain

KH-I_CeGLD3_3rd

Domain

18

false

GLD-3 from C.elegans, also called defective in germ line development protein 3, is a Bicaudal-C (Bic-C) homologue that is involved in the translational control of germline-specific mRNAs during embryogenesis. It interacts with the cytoplasmic poly(A)-polymerase GLD-2. The two proteins cooperate to recognize target mRNA...

[]

0

[ "PFAM" ]

[ "PF22467" ]

[ "KH_GLD-3_3rd" ]

[ 18 ]

1

[]

0

[ "3n89" ]

1

[ "PUB00091480" ]

[ "20823118" ]

[ "Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform." ]

[ 2010 ]

1

[]

0

null

[ "Caenorhabditis" ]

[ 18 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

GLD-3, KH3 domain

KH-I_CeGLD3_3rd

4

IPR055004

55,004

CFAP410, C-terminal domain

CFAP410_C

Domain

41

false

This entry represents the C-terminal domain of Trypanosoma brucei cilia and flagella associated protein 410 (CFAP410) and related proteins. This domain is involved in oligomerisation and self-associates to form a tetrameric helical bundle composed of a dimer of two interlocking dimers.

[]

0

[ "PFAM" ]

[ "PF22800" ]

[ "CFAP410_C" ]

[ 41 ]

1

[]

0

[ "8axo" ]

1

[]

0

[]

0

null

[ "Metakinetoplastina" ]

[ 41 ]

1

[]

0

true

Domain

CFAP410, C-terminal domain

CFAP410_C

5

IPR055005

55,005

S-layer protein, domain II

SlpA_D2

Domain

150

false

This domain is found in S-layer protein (SlpA) from Lactobacillus acidophilus and similar sequences. This domain is involved in the self-assembly and dimerisation of the S-layer. It adopts an α/β structure consisting of a curved mixed β-sheet and two α-helices packed on it. It has a partial structural similarity to the...

[]

0

[ "PFAM" ]

[ "PF22797" ]

[ "SlpA_D2" ]

[ 150 ]

1

[]

0

[ "7qec", "7qfl", "8bt9" ]

3

[ "PUB00154867" ]

[ "38838019" ]

[ "The molecular architecture of Lactobacillus S-layer: Assembly and attachment to teichoic acids." ]

[ 2024 ]

1

[]

0

null

[ "Lactobacillaceae" ]

[ 150 ]

1

[]

0

true

Domain

S-layer protein, domain II

SlpA_D2

5

IPR055006

55,006

S-layer protein, N-terminal domain

SlpA_N

Domain

113

false

This entry represents the N-terminal domain of S-layer protein SlpA from Lactobacillus amylovorus and related proteins. This domain adopts unusual topology composed of β-strands arranged in a barrel-sandwich fold [ ].

[]

0

[ "PFAM" ]

[ "PF22796" ]

[ "SlpA_N" ]

[ 113 ]

1

[]

0

[ "7qld", "7qle", "7qlh", "8q1o" ]

4

[ "PUB00154867" ]

[ "38838019" ]

[ "The molecular architecture of Lactobacillus S-layer: Assembly and attachment to teichoic acids." ]

[ 2024 ]

1

[]

0

null

[ "Lactobacillus" ]

[ 113 ]

1

[]

0

true

Domain

S-layer protein, N-terminal domain

SlpA_N

7

IPR055007

55,007

NACHT-associated inactive Restriction Endonuclease 2 domain

NA-iREase2_dom

Domain

70

false

This entry represents a predicted sensor domain in bacterial NACHT conflict systems. It is likely to bind a ligand which could contribute to activation of enzymatic domains additionally fused to the N terminus of the NACHT module [ ].

[]

0

[ "PFAM" ]

[ "PF22723" ]

[ "NA-iREase2" ]

[ 70 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 69, 1 ]

2

[]

0

true

Domain

NACHT-associated inactive Restriction Endonuclease 2 domain

NA-iREase2_dom

1

IPR055008

55,008

MrpR, C-terminal catalytic domain

MrpR_C_cat

Domain

277

false

This family includes the MrpR protein from Bacillus subtilis (also known as SPbeta prophage-derived protein YopR), the master repressor of the lytic cycle of the temperate phage SPbeta. MrpR, a DNA-binding protein that has lost its recombinase function, shows a tyrosine recombinase fold with an N-terminal all-α domain ...

[]

0

[ "PFAM" ]

[ "PF22823" ]

[ "MrpR_C_cat" ]

[ 277 ]

1

[]

0

[ "8a0a", "8bj6", "8bjv", "8bpz" ]

4

[ "PUB00154082" ]

[ "37602373" ]

[ "Structural and functional characterization of MrpR, the master repressor of the Bacillus subtilis prophage SPβ." ]

[ 2023 ]

1

[]

0

null

[ "Bacillota", "Viruses" ]

[ 258, 19 ]

2

[]

0

true

Domain

MrpR, C-terminal catalytic domain

MrpR_C_cat

9

IPR055011

55,011

Tag1, C-terminal domain

Tag1_C

Domain

1,152

false

This entry represents the C-terminal Ig-like domain of yeast Tag1 (also known as YLR173W). It shows homology to LEA-2 domain, and together with TMEM106B from humans and Vac7 from yeast, are all predicted to be lipid transfer proteins [ ]. Tag1 is a vacuolar membrane protein involved in termination of autophagy. It regu...

[]

0

[ "PFAM" ]

[ "PF22786" ]

[ "Tag1_C" ]

[ 1152 ]

1

[]

0

[]

0

[ "PUB00100166", "PUB00100170" ]

[ "34347309", "33536246" ]

[ "TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.", "Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae." ]

[ 2022, 2021 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1152 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1 ]

2

true

Domain

Tag1, C-terminal domain

Tag1_C

5

IPR055012

55,012

Tag1, N-terminal domain

Tag1_N

Domain

67

false

This entry represents the N-terminal domain of yeast Tag1 (also known as YLR173W). Tag1 is a vacuolar membrane protein involved in termination of autophagy. It regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly. It shows homology...

[]

0

[ "PFAM" ]

[ "PF20775" ]

[ "Tag1_N" ]

[ 67 ]

1

[]

0

[]

0

[ "PUB00100166", "PUB00100170" ]

[ "34347309", "33536246" ]

[ "TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.", "Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae." ]

[ 2022, 2021 ]

2

[]

0

null

[ "Saccharomycotina" ]

[ 67 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Tag1, N-terminal domain

Tag1_N

4

IPR055013

55,013

Cobalt-zinc-cadmium resistance protein CzcI

CzcI

Family

175

false

This entry represents a group of proteins from betaproteobacteria, including Cobalt-zinc-cadmium resistance protein CzcI from Cupriavidus metallidurans. CzcI is a component of the czc cation-efflux system that confers resistance to cobalt, zinc and cadmium [ , , ]. This protein may have a regulatory function.

[ "GO:0046686" ]

[ "response to cadmium ion" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "NF045614" ]

[ "efflu_CzcI_Cupr" ]

[ 175 ]

1

[]

0

[]

0

[ "PUB00046109", "PUB00154772", "PUB00154773" ]

[ "7766206", "32117100", "1459958" ]

[ "The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.", "Comparative Insights Into the Complete Genome Sequence of Highly Metal Resistant Cupriavidus metallidurans Strain BS1 Isolated From a Gold-Copper Mine.", "CzcR and CzcD, gene products affecting reg...

[ 1995, 2020, 1992 ]

3

[]

0

null

[ "Betaproteobacteria" ]

[ 175 ]

1

[]

0

true

Family

Cobalt-zinc-cadmium resistance protein CzcI

CzcI

5

IPR055014

55,014

BapA/Bap-like, C-terminal domain

BapA_Bap-like_C

Domain

1,956

false

This entry represents a conserved C-terminal region shared by a number of large adhesins of Gram-negative genera mainly from gammaproteobacteria. Most members of this entry have repeat domains N-terminal to the region described here, including bacterial Ig-like domains. Notable members of the family include biofilm-ass...

[]

0

[ "NCBIFAM" ]

[ "NF045619" ]

[ "adhes_GNV_Cterm" ]

[ 1956 ]

1

[]

0

[]

0

[ "PUB00105145", "PUB00154621", "PUB00154622" ]

[ "18024522", "21557055", "22083703" ]

[ "Identification and characterization of an Acinetobacter baumannii biofilm-associated protein.", "Adhesive mechanisms of Salmonella enterica.", "The Acinetobacter baumannii biofilm-associated protein plays a role in adherence to human epithelial cells." ]

[ 2008, 2011, 2012 ]

3

[]

0

null

[ "Bacteria", "Panagrolaimomorpha" ]

[ 1954, 2 ]

2

[]

0

true

Domain

BapA/Bap-like, C-terminal domain

BapA_Bap-like_C

6

IPR055015

55,015

3-coathanger stack domain

GCX_COOH

Domain

914

false

This entry represents a domain which is frequently found as C-terminal of a larger protein, typically with Gly-Cys-Xaa(-Xaa) as the last three (or four) amino acids, or just upstream from type IX secretion system (T9SS) C-terminal sorting signal domain. In from Spirosoma taeanense, a member of this group, this domain i...

[]

0

[ "NCBIFAM" ]

[ "NF045639" ]

[ "GCX_COOH" ]

[ 914 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 912, 2 ]

2

[]

0

true

Domain

3-coathanger stack domain

GCX_COOH

1

IPR055016

55,016

Uncharacterised protein Aq_1974-like

Aq_1974-like

Family

5

false

This protein family includes the uncharacterised protein Aq_1974 from Aquifex aeolicus and similar sequences from Aquificales. This protein has a tryptophan content five times the average. Its structure is mainly α-helical with a small two-stranded β-sheet forming a fold named 'Aromatic Claw' [ ].

[]

0

[ "PFAM" ]

[ "PF22323" ]

[ "Aq_1974-like" ]

[ 5 ]

1

[]

0

[ "5syq" ]

1

[ "PUB00153823" ]

[ "27750371" ]

[ "Aromatic claw: A new fold with high aromatic content that evades structural prediction." ]

[ 2017 ]

1

[]

0

null

[ "Aquificaceae" ]

[ 5 ]

1

[]

0

true

Family

Uncharacterised protein Aq_1974-like

Aq_1974-like

8

IPR055017

55,017

Tailspike protein, C-terminal domain

G7C_C

Domain

3

false

This entry represents the Concanavalin-like C-terminal domain of Tail fibre protein from Escherichia phage vB_EcoP_G7C ( ), also known as domain 6 (d6) of the tailspike receptor-binding protein (RBP) gp63.1. This domain is structurally similar to carbohydrate-binding domains and is putatively involved in substrate bind...

[]

0

[ "PFAM" ]

[ "PF22245" ]

[ "G7C_C" ]

[ 3 ]

1

[]

0

[ "4qnl" ]

1

[ "PUB00091258" ]

[ "28513100" ]

[ "Function of bacteriophage G7C esterase tailspike in host cell adsorption." ]

[ 2017 ]

1

[]

0

null

[ "Caudoviricetes" ]

[ 3 ]

1

[]

0

true

Domain

Tailspike protein, C-terminal domain

G7C_C

3

IPR055018

55,018

Zonadhesin, first cohesin-like domain

Zona_CL1

Domain

11

false

This entry represents the first cohesin-like domain present in zonadhesin protein from Pichia pastoris [ ].

[]

0

[ "PFAM" ]

[ "PF22320" ]

[ "Zona_CL1" ]

[ 11 ]

1

[]

0

[ "5fx8" ]

1

[ "PUB00154340" ]

[ "27313058" ]

[ "Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein." ]

[ 2016 ]

1

[]

0

null

[ "Komagataella" ]

[ 11 ]

1

[]

0

true

Domain

Zonadhesin, first cohesin-like domain

Zona_CL1

4

IPR055019

55,019

Zonadhesin, second cohesin-like domain

Zona_CL2

Domain

12

false

This entry represents the second cohesin-like domain present in zonadhesin protein from Pichia pastoris [ ].

[]

0

[ "PFAM" ]

[ "PF22321" ]

[ "Zona_CL2" ]

[ 12 ]

1

[]

0

[ "5fx8" ]

1

[ "PUB00154340" ]

[ "27313058" ]

[ "Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein." ]

[ 2016 ]

1

[]

0

null

[ "Saccharomycotina" ]

[ 12 ]

1

[]

0

true

Domain

Zonadhesin, second cohesin-like domain

Zona_CL2

2

IPR055020

55,020

Avirulence protein AvrPiz-t

AvrPiz-t

Family

13

false

This entry represents avirulence protein AvrPiz-t from Magnaporthe oryzae [ ]. It is predicted to be secreted and it can suppress programmed cell death (PCD) induced by BAX in tobacco which suggests that it might contribute to the pathogenicity of M.oryzae. This domain adopts a six-stranded β-sandwich .

[]

0

[ "PFAM" ]

[ "PF22347" ]

[ "AvrPiz-t" ]

[ 13 ]

1

[]

0

[ "2lw6" ]

1

[ "PUB00066029" ]

[ "23334361" ]

[ "Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t." ]

[ 2013 ]

1

[]

0

null

[ "Pyricularia" ]

[ 13 ]

1

[]

0

true

Family

Avirulence protein AvrPiz-t

AvrPiz-t

6

IPR055022

55,022

Halocin C8-like, N-terminal domain

HalC8-like_N

Domain

49

false

This is a presumed domain found at the N-terminal of halocin C8 and similar sequences from archaea. Halocins are bacteriocin-like proteins or peptides produced by many species of the family Halobacteriaceae. Halocin C8 is derived from the C terminus of a 283 amino-acid prepro-protein (ProC8) [ ]. The N-terminal peptide...

[]

0

[ "PFAM" ]

[ "PF22862" ]

[ "HalC8_like_N" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00074361", "PUB00154869", "PUB00154870" ]

[ "18658263", "12811620", "15978083" ]

[ "The helix-loop-helix motif at the N terminus of HalI is essential for its immunity function against halocin C8.", "Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.", "A single gene directs both production and immunity of halocin C8 in a ha...

[ 2008, 2003, 2005 ]

3

[]

0

null

[ "Halobacteriales" ]

[ 49 ]

1

[]

0

true

Domain

Halocin C8-like, N-terminal domain

HalC8-like_N

6

IPR055023

55,023

Colicin-A, N-terminal domain

ColA_N

Domain

15

false

This entry represents the N-terminal translocation domain of colicin A, an endonuclease active on both single- and double-stranded DNA but with undefined specificity [ , ]. This domain interacts directly with TolAIII (C-terminal domain of TolA) which facilitates translocation through the cell envelope to reach their cy...

[]

0

[ "PFAM" ]

[ "PF22348" ]

[ "ColA_N" ]

[ 15 ]

1

[]

0

[ "3iax", "3qdr" ]

2

[ "PUB00058538", "PUB00059427" ]

[ "19627502", "22493500" ]

[ "The crystal structure of the TolB box of colicin A in complex with TolB reveals important differences in the recruitment of the common TolB translocation portal used by group A colicins.", "Structural Evidence That Colicin A Protein Binds to a Novel Binding Site of TolA Protein in Escherichia coli Periplasm." ]

[ 2010, 2012 ]

2

[]

0

null

[ "Enterobacterales" ]

[ 15 ]

1

[]

0

true

Domain

Colicin-A, N-terminal domain

ColA_N

5

IPR055024

55,024

Endo-beta-N-acetylglucosaminidase EndoS, helical bundle

EndoS_helical

Domain

24

false

This entry represents a three-helical up-and-down bundle domain of EndoS from Streptococcus pyogenes and similar bacterial proteins. EndoS is involved in immune evasion mechanisms and possesses a specific endoglycosidase activity that targets IgG antibodies [ , ].

[]

0

[ "PFAM" ]

[ "PF22382" ]

[ "EndoS_helical" ]

[ 24 ]

1

[]

0

[ "4nuy", "4nuz", "6en3", "8a49", "8a64", "8w4g", "8w4i", "8w4n", "8x8g" ]

9

[ "PUB00151608", "PUB00151610" ]

[ "24753590", "29760474" ]

[ "Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.", "Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S." ]

[ 2014, 2018 ]

2

[]

0

null

[ "Streptococcus" ]

[ 24 ]

1

[]

0

true

Domain

Endo-beta-N-acetylglucosaminidase EndoS, helical bundle

EndoS_helical

8

IPR055025

55,025

ToxT, N-terminal cupin-like domain

ToxT_N

Domain

13

false

This entry represents a cupin-like domain present in ToxT from Vibrio Cholerae ( , ) [ , ]. ToxT serves as the culminating factor in the regulatory pathway, ensuring the coordinated production of two virulence factors: the toxin-coregulated pilus (TCP) and cholera toxin (CT), which are crucial for the pathogenicity of ...

[]

0

[ "PFAM" ]

[ "PF22404" ]

[ "ToxT_N" ]

[ 13 ]

1

[]

0

[ "3gbg", "4mlo", "5suw", "5sux", "6p7r", "6p7t", "6pb9" ]

7

[ "PUB00097575", "PUB00097576", "PUB00154292", "PUB00154293" ]

[ "20133655", "27599865", "31815195", "21673111" ]

[ "Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.", "1.65 A resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.", "Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components ...

[ 2010, 2016, 2019, 2011 ]

4

[]

0

null

[ "Vibrio" ]

[ 13 ]

1

[]

0

true

Domain

ToxT, N-terminal cupin-like domain

ToxT_N

5

IPR055026

55,026

AVR-Pik-like, HMA interaction domain

AVR-Pik_HID

Domain

18

false

This entry represents the HMA interaction domain of AVR-Pik { ), an effector protein from the rice blast fungus Pyricularia oryzae which binds and stabilizes rice HMA-domain containing NLR proteins to co-opt their function to suppress immunity [ , , , , ]. AVR-Pik adopts a six-stranded β-sandwich structure.

[]

0

[ "PFAM" ]

[ "PF22383" ]

[ "AVR-Pik_HID" ]

[ 18 ]

1

[]

0

[ "5a6w", "6fu9", "6fub", "6fud", "6g10", "6g11", "6r8k", "6r8m", "7a8w", "7a8x", "7b1i", "7bnt", "7nlj", "7nmm", "7qpx", "7qzd", "8b2r", "9imu" ]

18

[ "PUB00110005", "PUB00110006", "PUB00110007", "PUB00110008", "PUB00110009" ]

[ "26304198", "29988155", "31535976", "33647072", "33548226" ]

[ "Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.", "Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen.", "Protein engineering expands the effector recognition profile of a rice NLR immune receptor.", "The allel...

[ 2015, 2018, 2019, 2021, 2021 ]

5

[]

0

null

[ "Pyricularia" ]

[ 18 ]

1

[]

0

true

Domain

AVR-Pik-like, HMA interaction domain

AVR-Pik_HID

7

IPR055027

55,027

CRISPR-associated endonuclease Cas9, C-terminal domain

Cas9_C_2

Domain

9

false

This domain is found at the C-terminal end of CRISPR-associated endonuclease Cas9 from the gammaproteobacteria Francisella tularensis [ ].

[]

0

[ "PFAM" ]

[ "PF22385" ]

[ "Cas9_C_2" ]

[ 9 ]

1

[]

0

[ "5b2o", "5b2p", "5b2q", "9ehf", "9ehg", "9ehh", "9ehr", "9ehw", "9ehx", "9n6t" ]

10

[ "PUB00152856" ]

[ "26875867" ]

[ "Structure and Engineering of Francisella novicida Cas9." ]

[ 2016 ]

1

[]

0

null

[ "Francisella" ]

[ 9 ]

1

[]

0

true

Domain

CRISPR-associated endonuclease Cas9, C-terminal domain

Cas9_C_2

7

IPR055028

55,028

Methylated DNA-protein cysteine MeTransferase OGT, N-terminal domain

OGT_N

Domain

10

false

This entry represents the N-terminal of methylated DNA-protein cysteine methyltransferase (MGMT, also known as 6-O-methylguanine-DNA methyltransferase and MJ1529/OGT) from Methanocaldococcus jannaschii and similar sequences [ ]. This entry corresponds to the ribonuclease-like domain associated with 6-O-methylguanine DN...

[]

0

[ "PFAM" ]

[ "PF22413" ]

[ "OGT_N" ]

[ 10 ]

1

[]

0

[ "2g7h" ]

1

[ "PUB00040953" ]

[ "16826543" ]

[ "Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase." ]

[ 2006 ]

1

[]

0

null

[ "Methanocaldococcaceae" ]

[ 10 ]

1

[]

0

true

Domain

Methylated DNA-protein cysteine MeTransferase OGT, N-terminal domain

OGT_N

2

IPR055029

55,029

EhRGS-RhoGEF, PH domain-like

EhRGS-RhoGEF_PH-like

Domain

10

false

This entry represents the PH-like domain of a RGS-RhoGEF from Entamoeba histolytica (EhRGS-RhoGEF, ) which, like its mammalian homologues, serves as an EhGalpha1 effector and signals through Rho family GTPases playing important roles in its pathogenesis [ ]. This domain mediates activation of Rho family GTPases.

[]

0

[ "PFAM" ]

[ "PF22418" ]

[ "EhRGS-RhoGEF_PH-like" ]

[ 10 ]

1

[]

0

[ "4gou" ]

1

[ "PUB00153920" ]

[ "23260656" ]

[ "Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis." ]

[ 2013 ]

1

[]

0

null

[ "Entamoeba" ]

[ 10 ]

1

[]

0

true

Domain

EhRGS-RhoGEF, PH domain-like

EhRGS-RhoGEF_PH-like

2

IPR055030

55,030

Carbohydrate binding module 74

Cbm74

Domain

15

false

This entry represents a Carbohydrate binding module from Ruminococcus flavefaciens (Cbm74-rfgh5, ) and similar sequences. This domain adopts a β-sandwich fold typical of carbohydrate binding modules (CBMs) ( ) [ ].

[]

0

[ "PFAM" ]

[ "PF22579" ]

[ "Cbm74" ]

[ 15 ]

1

[]

0

[ "5aos", "5aot", "5fu2", "5fu3", "5fu4" ]

5

[ "PUB00091246" ]

[ "27298375" ]

[ "Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition." ]

[ 2016 ]

1

[]

0

null

[ "Ruminococcus" ]

[ 15 ]

1

[]

0

true

Domain

Carbohydrate binding module 74

Cbm74

5

IPR055031

55,031

Colicin S4, translocation domain

Csa_translocation_dom

Domain

16

false

This entry represents the N-terminal translocation domain of Colicin S4 from Escherichia coli (Csa, ), a polypeptide toxin produced and active against E.coli. This protein consists of four distinct domains, this domain, two receptor-binding domains and the C-terminal pore-forming domain ( ). This domain shows an antipa...

[]

0

[ "PFAM" ]

[ "PF22512" ]

[ "Csa_translocation_dom" ]

[ 16 ]

1

[]

0

[ "3few" ]

1

[ "PUB00051950" ]

[ "19056731" ]

[ "Structure and function of colicin S4, a colicin with a duplicated receptor-binding domain." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria" ]

[ 16 ]

1

[]

0

true

Domain

Colicin S4, translocation domain

Csa_translocation_dom

1

IPR055032

55,032

Class 2 C-terminal docking domain

Class_2_docking_dom

Domain

4

false

This short domain is found at the C-terminal end of the polyketide synthase module CurG from the cyanobacteria Moorena producens ( ). It consists of two α-helices connected by a sharp bend ( ) [ ].

[]

0

[ "PFAM" ]

[ "PF22488" ]

[ "Class_2_docking_dom" ]

[ 4 ]

1

[]

0

[ "4myy" ]

1

[ "PUB00153871" ]

[ "24183970" ]

[ "Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis." ]

[ 2013 ]

1

[]

0

null

[ "Cyanophyceae" ]

[ 4 ]

1

[]

0

true

Domain

Class 2 C-terminal docking domain

Class_2_docking_dom

7

IPR055034

55,034

Mu Gam/Sipho_Gp157-like domain of the TOTE conflict systems

Mu_Gam-Sipho_Gp157-TOTE

Domain

22

false

This entry represents a DNA/RNA hybrid duplex binding domain found in the TOTE (TPR, OB, TBP, Effector) conflict systems [ ]. This domain occasionally displaces the more widely observed TOTE-TPR domain [ ].

[]

0

[ "PFAM" ]

[ "PF22709" ]

[ "Mu_Gam-Sipho_Gp157-TOTE" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00153788" ]

[ "35609893" ]

[ "Discovering Biological Conflict Systems Through Genome Analysis: Evolutionary Principles and Biochemical Novelty." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanogaster sp." ]

[ 21, 1 ]

2

[]

0

true

Domain

Mu Gam/Sipho_Gp157-like domain of the TOTE conflict systems

Mu_Gam-Sipho_Gp157-TOTE

7

IPR055035

55,035

DNA transposase THAP9, C-terminal domain

THAP9_C

Domain

3,244

false

This domain is found at the C-terminal of human DNA transposase THAP9 and similar proteins mainly from vertebrates. This domain is predicted to be mainly formed by α-helices.

[]

0

[ "PFAM" ]

[ "PF22824" ]

[ "THAP9_C" ]

[ 3244 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Metazoa" ]

[ 3244 ]

1

[ "Danio rerio", "Homo sapiens" ]

[ 1, 1 ]

2

true

Domain

DNA transposase THAP9, C-terminal domain

THAP9_C

6

IPR055036

55,036

Short NACHT-associated C-terminal domain, family 5

SNaCT5

Domain

59

false

The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N-terminal of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they in...

[]

0

[ "PFAM" ]

[ "PF22711" ]

[ "SNaCT5" ]

[ 59 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Clostridium phage CDMH1" ]

[ 58, 1 ]

2

[]

0

true

Domain

Short NACHT-associated C-terminal domain, family 5

SNaCT5

6