LiteFold/InterPro · Datasets at Hugging Face

IPR056403

56,403

Ribonuclease II-like, barrel domain

RNase_II_barrel

Domain

1,011

false

This domain is found at the N-terminal of ribonuclease II (RNR1) from Arabidopsis thaliana and similar sequences from plants and cyanobacteria. This domain may have an RNA-binding activity. RNR1 is a 3'-5' exoribonuclease that catalyses 3' maturation of chloroplast and mitochondrion ribosomal RNAs. It degrades short nu...

[]

0

[ "PFAM" ]

[ "PF23163" ]

[ "CSD_RNase_II" ]

[ 1011 ]

1

[]

0

[]

0

[ "PUB00158851", "PUB00158852" ]

[ "15891117", "23061883" ]

[ "RNR1, a 3'-5' exoribonuclease belonging to the RNR superfamily, catalyzes 3' maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana.", "Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation." ]

[ 2005, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 321, 690 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 7 ]

3

true

Domain

Ribonuclease II-like, barrel domain

RNase_II_barrel

7

IPR056404

56,404

Ribonuclease II-like, double HTH domain

HTH_RNase_II

Domain

1,564

false

This entry represents a double HTH domain found in a set of ribonuclease II proteins mainly found in bacteria and plants [ ]. RNR1 is a 3'-5' exoribonuclease that catalyses 3' maturation of chloroplast and mitochondrion ribosomal RNAs. It degrades short nucleotidic extensions to generate the mature 3'-ends [ , ]. It is...

[]

0

[ "PFAM" ]

[ "PF23161" ]

[ "HTH_RNase_II" ]

[ 1564 ]

1

[]

0

[ "2r7d", "2r7f" ]

2

[ "PUB00057529", "PUB00158851", "PUB00158852" ]

[ "22133431", "15891117", "23061883" ]

[ "The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans.", "RNR1, a 3'-5' exoribonuclease belonging to the RNR superfamily, catalyzes 3' maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana.", "Ribonuclease II preserves chloroplast RNA homeostasis by in...

[ 2012, 2005, 2012 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 778, 769, 17 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 10 ]

3

true

Domain

Ribonuclease II-like, double HTH domain

HTH_RNase_II

2

IPR056405

56,405

CUL7/CUL9, ARM-repeats domain

ARM_CUL7_CUL9

Domain

1,369

false

This domain is found in human Cillin-7 (CUL7), Cullin-9 (CUL9) and related proteins. CUL7 is a core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins [ ]. CUL9, a core component of the Cul9-RING ubiquitin-protein ligase complex, acts downstream of the 3M complex, w...

[]

0

[ "PFAM" ]

[ "PF24742" ]

[ "ARM_CUL7_CUL9" ]

[ 1369 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381038", "R-HSA-8951664", "R-HSA-983168", "R-MMU-983168", "R-RNO-8951664", "R-RNO-983168" ]

[ "REACTOME:R-HSA-381038", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-8951664", "REACTOME:R-RNO-983168" ]

6

[ "7z8b", "8q7e", "8q7h", "8rhz" ]

4

[ "PUB00075111", "PUB00075113" ]

[ "24793696", "24793695" ]

[ "CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.", "The 3M complex maintains microtubule and genome integrity." ]

[ 2014, 2014 ]

2

[]

0

null

[ "Chordata" ]

[ 1369 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 9, 6, 8 ]

4

true

Domain

CUL7/CUL9, ARM-repeats domain

ARM_CUL7_CUL9

6

IPR056406

56,406

CWZF3/5/7, THD domain

THD_CWZF3/5/7

Domain

2,021

false

This domain is found at the C-terminal end of Cysteine-tryptophan domain-containing zinc finger proteins 3, 5 and 7 from Oryza sativa and related plant proteins. This domain has a significant similarity to the THD domain (TPRL with Handle Region Dimerisation Domain) of AFF4, which is a scaffold protein that recruits ot...

[]

0

[ "PFAM" ]

[ "PF24756" ]

[ "THD_CWZF3-5-7" ]

[ 2021 ]

1

[]

0

[]

0

[ "PUB00155324", "PUB00155325" ]

[ "28818372", "31830332" ]

[ "Functional characterization of rice CW-domain containing zinc finger proteins involved in histone recognition.", "Wide Grain 7 increases grain width by enhancing H3K4me3 enrichment in the OsMADS1 promoter in rice (Oryza sativa L.)." ]

[ 2017, 2020 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2021 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 23, 6, 81 ]

3

true

Domain

CWZF3/5/7, THD domain

THD_CWZF3/5/7

1

IPR056408

56,408

CT021-like

Family

48

false

This entry represents the hypothetical protein CT021 from Chlamydia trachomatis ( ) and related proteins. The structure of this protein ( ) consists of β-meander that folds into an open β-barrel packed on a side with two α-helices. It structurally resembles the N-terminal domain of Sigma-E factor regulatory protein rse...

[]

0

[ "PFAM" ]

[ "PF24683" ]

[ "CT021" ]

[ 48 ]

1

[]

0

[ "6uxd" ]

1

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 46, 2 ]

2

[]

0

true

Family

CT021-like

3

IPR056409

56,409

CYK3, C-terminal Ig-like domain

Ig_CYK3_C

Domain

1,231

false

This domain is found at the C terminus of yeast Cytokinesis protein 3 (CYK3) and related fungal proteins. CYK3 is involved in cytokinesis by recruiting INN1 to the bud neck. It is found in association with the actin ring and the mother-bud neck [ , ]. This domain is predicted to fold into a β-sandwich with an Ig-like t...

[]

0

[ "PFAM" ]

[ "PF24584" ]

[ "Ig_CYK3_C" ]

[ 1231 ]

1

[]

0

[]

0

[ "PUB00085672", "PUB00128467" ]

[ "19707790", "10959846" ]

[ "Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.", "Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast." ]

[ 2009, 2000 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1231 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Domain

CYK3, C-terminal Ig-like domain

Ig_CYK3_C

2

IPR056410

56,410

Cyanophage outer membrane protein-like, beta-barrel domain

Phage_OMP

Domain

140

false

This entry includes a family of small uncharacterised membrane bound β-barrel-like proteins found in cyanophage. The putative membrane β-barrel is incomplete, composed of only 6 β-strands. However, the proteins form a confident homodimer composed of a flattened 12 stranded β-barrel. The proteins likely contain an N-ter...

[]

0

[ "PFAM" ]

[ "PF24653" ]

[ "Phage_OMP" ]

[ 140 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Vibrio sp. HB236076", "Viruses", "marine metagenome" ]

[ 1, 137, 2 ]

3

[]

0

true

Domain

Cyanophage outer membrane protein-like, beta-barrel domain

Phage_OMP

6

IPR056412

56,412

Cytochrome c-type biogenesis protein H, Ig-like domain

Ig_CycH

Domain

3,730

false

This entry represents the immunoglobulin-like domain found in cytochrome c-type biogenesis protein CycH from bacteria. CycH is involved in the attachment of heme to cytochrome c apoproteins [ ]. This entry also represents the Ig-like domain of the uncharacterised protein AQ_1241 from Aquifex aeolicus. The function of t...

[]

0

[ "PFAM" ]

[ "PF23892" ]

[ "Ig_CycH" ]

[ 3730 ]

1

[]

0

[]

0

[ "PUB00002276" ]

[ "7665469" ]

[ "Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3650, 7, 73 ]

3

[]

0

true

Domain

Cytochrome c-type biogenesis protein H, Ig-like domain

Ig_CycH

5

IPR056414

56,414

DAAF9, CobW C-like domain

DAAF9_CobW_C

Domain

920

false

This domain is found in the human DAAF9 and related proteins. It binds newly synthesised outer dynein arm complexes [ ]. It shares a significant sequence similarity with the C-terminal domain of CobW and it is predicted to adopt a similar structure consisting of a flat antiparallel β-sheet and two α-helices packed on i...

[]

0

[ "PFAM" ]

[ "PF23319" ]

[ "CobW_C_DAAF9" ]

[ 920 ]

1

[]

0

[]

0

[ "PUB00109577" ]

[ "33632841" ]

[ "Shulin packages axonemal outer dynein arms for ciliary targeting." ]

[ 2021 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 920 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4, 5 ]

4

true

Domain

DAAF9, CobW C-like domain

DAAF9_CobW_C

1

IPR056415

56,415

DCDC1, second doublecortin-like domain

DCX2_DCDC1

Domain

692

false

This is the second doublecortin-like domain (DCX2) of DCDC1. This domain shows an ubiquitin-like fold. Doublecortin domain-containing protein 1 (DCDC1), also known as DCDC5, is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like ter...

[]

0

[ "PFAM" ]

[ "PF24478" ]

[ "DCX2_DCDC1" ]

[ 692 ]

1

[]

0

[]

0

[ "PUB00093782" ]

[ "22159412" ]

[ "Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein." ]

[ 2011 ]

1

[]

0

null

[ "Eukaryota" ]

[ 692 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 1 ]

3

true

Domain

DCDC1, second doublecortin-like domain

DCX2_DCDC1

5

IPR056416

56,416

DBL homology domain, fungi

DH_2_fung

Domain

1,027

false

This domain is found in uncharacterised fungal proteins. It shares significant sequence similarity to known DBL homology domains (DH-domains) and it is predicted to adopt similar structure. Proteins containing this domain also contain a PH-domain located upstream the DH-domain and are likely members of the Dbl family o...

[]

0

[ "PFAM" ]

[ "PF24340" ]

[ "DH_2" ]

[ 1027 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "saccharomyceta" ]

[ 1027 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

DBL homology domain, fungi

DH_2_fung

3

IPR056418

56,418

Tail tube terminator protein p142

Phage_tail_terminator_p142

Family

229

false

The Tail Tube Terminator Protein family is involved in the assembly of bacteriophage tail structures. Members of this family, such as the Tail Tube Terminator Protein p142, are responsible for capping the tail tube during its polymerisation, ensuring that it reaches the correct length [ ]. This capping function is cruc...

[]

0

[ "PFAM" ]

[ "PF23818" ]

[ "Phage_tail_terminator_7" ]

[ 229 ]

1

[]

0

[ "8bcp", "8bcu", "8hqo", "9ilv", "9imh" ]

5

[ "PUB00155631" ]

[ "36961893" ]

[ "Structural basis of bacteriophage T5 infection trigger and <i>E. coli</i> cell wall perforation." ]

[ 2023 ]

1

[]

0

null

[ "Viruses", "ecological metagenomes" ]

[ 222, 7 ]

2

[]

0

true

Family

Tail tube terminator protein p142

Phage_tail_terminator_p142

6

IPR056419

56,419

Bardet-Biedl syndrome 1 protein, GAE domain

GAE_BBS1

Domain

1,688

false

This entry represents the GAE domain of BBS1, found at the C terminus. It adopts a β-sandwich fold [ ]. This domain mediates interactions with other subunits (BBS8 and BBS9) of the complex. Bardet-Biedl syndrome is characterised by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism,...

[]

0

[ "PFAM" ]

[ "PF23304" ]

[ "GAE_BBS1" ]

[ 1688 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5620922", "R-HSA-5620922", "R-MMU-5620922" ]

[ "REACTOME:R-CEL-5620922", "REACTOME:R-HSA-5620922", "REACTOME:R-MMU-5620922" ]

3

[ "6vbu", "6vbv", "6vnw", "6voa", "6xt9" ]

5

[ "PUB00043592", "PUB00043593", "PUB00060532", "PUB00069263", "PUB00069264", "PUB00153353", "PUB00153354", "PUB00153355" ]

[ "18334641", "18032602", "17574030", "12118255", "22072986", "25402481", "31939736", "31951201" ]

[ "Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.", "A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.", "A core complex of BBS proteins cooperates with the GTPase Ra...

[ 2008, 2007, 2007, 2002, 2011, 2014, 2020, 2020 ]

8

[]

0

null

[ "Eukaryota" ]

[ 1688 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 5, 4, 4 ]

6

true

Domain

Bardet-Biedl syndrome 1 protein, GAE domain

GAE_BBS1

9

IPR056420

56,420

Gem-associated protein 5, RBS domain

GEMI5_RBS

Domain

1,230

false

This entry represents the RNA-binding domains RBS1 and RBS2 found at the C-terminal of Gem-associated protein 5 (GEMI5) from vertebrates. The RBS1 domain is involved in the recognition of viral IRES elements and cellular RNAs. This domain is intrinsically unstructured and interacts with RNA through conserved Arg and ar...

[]

0

[ "PFAM" ]

[ "PF23777" ]

[ "GEMI5_RBS" ]

[ 1230 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]

[ "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]

3

[ "7xdt", "7xgr" ]

2

[ "PUB00155534", "PUB00155535", "PUB00155635", "PUB00155636" ]

[ "16857593", "35987821", "32485878", "34424823" ]

[ "The Gemin5 protein of the SMN complex identifies snRNAs.", "Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs.", "Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control.", "The RBS1 domain of Gemin5 is intrinsically unstructured and in...

[ 2006, 2022, 2020, 2021 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 1230 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 7, 2 ]

4

true

Domain

Gem-associated protein 5, RBS domain

GEMI5_RBS

4

IPR056422

56,422

BP74, N-terminal domain

BP74_N

Domain

464

false

This domain is found at the N-terminal of the Cyclic AMP-inducible protein BP74 from Dictyostelium discoideum and related proteins. The BP74 gene is a cyclic AMP-regulated and expressed during the Dictyostelium development [ ]. This domain is predicted to fold into an open β-barrel capped with two α-helices.

[]

0

[ "PFAM" ]

[ "PF23621" ]

[ "BP74_N" ]

[ 464 ]

1

[]

0

[]

0

[ "PUB00155560" ]

[ "2555685" ]

[ "Expression and organization of BP74, a cyclic AMP-regulated gene expressed during Dictyostelium discoideum development." ]

[ 1989 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 5, 380, 71, 8 ]

4

[]

0

true

Domain

BP74, N-terminal domain

BP74_N

1

IPR056424

56,424

Gem-associated protein 5, second beta-propeller domain

Beta-prop_GEMI5_2nd

Domain

1,630

false

This entry represents the second β-propeller found in Gem-associated protein 5 (GEMI5) from vertebrates and its orthologue from Drosophila melanogaster, Protein rigor mortis (RIG). The β-propellers in GEMI5 bind small nuclear RNAs (snRNAs) playing a critical role in the assembly of the heptameric Sm protein core on snR...

[]

0

[ "PFAM" ]

[ "PF23775" ]

[ "Beta-prop_RIG_2nd" ]

[ 1630 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]

[ "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]

3

[ "5gxh", "5gxi", "5h1j", "5h1k", "5h1l", "5h1m", "5h3s", "5h3t", "5h3u", "5tee", "5tef", "5tha" ]

12

[ "PUB00155010", "PUB00155534", "PUB00155535", "PUB00155536", "PUB00155635" ]

[ "14645129", "16857593", "35987821", "31799608", "32485878" ]

[ "rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.", "The Gemin5 protein of the SMN complex identifies snRNAs.", "Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs.", ...

[ 2004, 2006, 2022, 2020, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1630 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 3, 6, 2 ]

5

true

Domain

Gem-associated protein 5, second beta-propeller domain

Beta-prop_GEMI5_2nd

7

IPR056425

56,425

BT_1020-like, N-terminal beta-propeller

Beta-prop_BT_1020

Domain

607

false

This entry represents the N-terminal region of BT_1020 from Bacteroides thetaiotaomicron ( ), which covers part of its 5-bladed β-propeller domain. It is usually found associated with .

[]

0

[ "PFAM" ]

[ "PF24067" ]

[ "Beta-prop_BT_1020" ]

[ 607 ]

1

[]

0

[ "5mqr", "5mqs" ]

2

[ "PUB00103952" ]

[ "28329766" ]

[ "Complex pectin metabolism by gut bacteria reveals novel catalytic functions." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Dikarya", "metagenomes" ]

[ 551, 48, 8 ]

3

[]

0

true

Domain

BT_1020-like, N-terminal beta-propeller

Beta-prop_BT_1020

3

IPR056426

56,426

BTBDG, BTB/POZ domain

BTB_BTBDG

Domain

503

false

This entry represents the BTB/POZ domain found at the N-terminal of BTB/POZ domain-containing protein 16 (BTBDG) from animals. The function of BTBDG is not clear.

[]

0

[ "PFAM" ]

[ "PF23998" ]

[ "BTB_BTBDG" ]

[ 503 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 503 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 2, 4, 2 ]

4

true

Domain

BTBDG, BTB/POZ domain

BTB_BTBDG

5

IPR056427

56,427

Gene 1 ring forming protein domain

G1RFP_dom

Domain

65

false

This entry represents a domain found in an uncharacterised family of bacteriophage proteins annotated as gene 1. These proteins form a pair of α-helices that interact with each other. These proteins are predicted to form large ring structures, with 13-15 subunits having the highest predicted scores. Once the rings are ...

[]

0

[ "PFAM" ]

[ "PF24182" ]

[ "G1RFP" ]

[ 65 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Azospirillum cavernae", "Viruses" ]

[ 1, 64 ]

2

[]

0

true

Domain

Gene 1 ring forming protein domain

G1RFP_dom

4

IPR056428

56,428

General transcription factor 3C polypeptide 1, winged-helix domain

WH_GTF3C1

Domain

2,161

false

This is the winged-helix (WH) domain found at the N-terminal of human General transcription factor 3C polypeptide 1 (GTF3C1, also known as TFIIIC220) and similar eukaryotic sequences. GTF3C1 is required for RNA polymerase III-mediated transcription. It binds to the box B promoter element.TFIIIC assembles the initiation...

[]

0

[ "PFAM" ]

[ "PF23704" ]

[ "WHD_GTF3C1_N" ]

[ 2161 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061", "R-MMU-76066", "R-RNO-76061", "R-RNO-76066" ]

[ "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-RNO-76061", "REACTOME:R-RNO-76066" ]

7

[ "8cli", "8clj", "8clk", "8cll" ]

4

[ "PUB00155917" ]

[ "37418517" ]

[ "Structural insights into human TFIIIC promoter recognition." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2161 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 2, 1, 3, 7, 10, 9, 28 ]

8

true

Domain

General transcription factor 3C polypeptide 1, winged-helix domain

WH_GTF3C1

6

IPR056429

56,429

C-Maf-inducing protein, PH domain

PH_CMIP

Domain

1,563

false

This entry represents the PH domain found in C-Maf-inducing protein and related proteins from animals. The human C-Maf-inducing protein is involved in T-cell signalling pathways [ , ]. Proteins containing this domain are implicated in the regulation of immune responses, particularly in the differentiation and function ...

[]

0

[ "PFAM" ]

[ "PF23066" ]

[ "PH_21" ]

[ 1563 ]

1

[]

0

[]

0

[ "PUB00158854", "PUB00158855" ]

[ "12939343", "15128042" ]

[ "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization.", "The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1563 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4 ]

4

true

Domain

C-Maf-inducing protein, PH domain

PH_CMIP

3

IPR056430

56,430

C2 domain-containing protein 5, forth YbjQ-like domain

C2CD5_YbjQ-like_dom

Domain

3,569

false

This domain is found in human C2 domain-containing protein 5 (C2CD5) and similar proteins mainly from animals. C2CD5 is required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. This domain is predicted to show a β-sheet and an α-helix. C2...

[]

0

[ "PFAM" ]

[ "PF23028" ]

[ "YbjQ_3" ]

[ 3569 ]

1

[ "REACTOME" ]

[ "R-HSA-1445148" ]

[ "REACTOME:R-HSA-1445148" ]

1

[]

0

[ "PUB00068956", "PUB00087624" ]

[ "21907143", "25096995" ]

[ "C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.", "Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration." ]

[ 2011, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3569 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 50, 5, 4, 4, 10 ]

5

true

Domain

C2 domain-containing protein 5, forth YbjQ-like domain

C2CD5_YbjQ-like_dom

9

IPR056431

56,431

C2 domain-containing protein 5, YbjQ-like domain

C2CD5_YbjQ-rel_dom

Domain

4,193

false

This domain is found in several copies in human C2 domain -containing protein 5 (C2CD5) and similar proteins predominantly found in animals. C2CD5 is required for insulin-stimulated glucose transport and glucose transporter SLC2A4 /GLUT4 translocation to the plasma membrane in adipocytes. This domain is predicted to sh...

[]

0

[ "PFAM" ]

[ "PF23025" ]

[ "YbjQ_2" ]

[ 4193 ]

1

[ "REACTOME" ]

[ "R-HSA-1445148" ]

[ "REACTOME:R-HSA-1445148" ]

1

[]

0

[ "PUB00068956", "PUB00087624" ]

[ "21907143", "25096995" ]

[ "C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.", "Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration." ]

[ 2011, 2014 ]

2

[]

0

null

[ "Eukaryota", "Limosilactobacillus" ]

[ 4181, 12 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 50, 5, 5, 6, 10 ]

6

true

Domain

C2 domain-containing protein 5, YbjQ-like domain

C2CD5_YbjQ-rel_dom

2

IPR056433

56,433

DmsR-like, N-terminal

DmsR-like_N

Domain

716

false

This domain is found at the N-terminal of Dimethyl sulfoxide reductase transcriptional activator from Haloferax volcanii (DmsR), Transcriptional regulator NarO from Haloferax volcanii, and similar proteins from halobacteria. DmsR is required for anaerobic respiration on dimethyl sulfoxide (DMSO) [ , ]. NarO activates t...

[]

0

[ "PFAM" ]

[ "PF24277" ]

[ "DmsR_N" ]

[ 716 ]

1

[]

0

[]

0

[ "PUB00092107", "PUB00151374", "PUB00155606", "PUB00160129" ]

[ "15716436", "26507955", "22865851", "26787768" ]

[ "Genomic analysis of anaerobic respiration in the archaeon Halobacterium sp. strain NRC-1: dimethyl sulfoxide and trimethylamine N-oxide as terminal electron acceptors.", "Transcriptional regulation of dimethyl sulfoxide respiration in a haloarchaeon, Haloferax volcanii.", "Genome-wide responses of the model ar...

[ 2005, 2016, 2012, 2016 ]

4

[]

0

null

[ "Halobacteriales" ]

[ 716 ]

1

[]

0

true

Domain

DmsR-like, N-terminal

DmsR-like_N

3

IPR056434

56,434

GEX2, N-terminal Ig-like domain

Ig_GEX2_N

Domain

627

false

This domain is found at the N-terminal of Arabidopsis GAMETE EXPRESSED 2 (GEX2) and related plant proteins. GEX2 is localised at the sperm membrane and contains a number of extracellular Ig-like domains. GEX2 is required for gamete attachment [ ]. The domain represented by this entry adopts a β-sandwich structure with ...

[]

0

[ "PFAM" ]

[ "PF23616" ]

[ "Ig_GEX2_N" ]

[ 627 ]

1

[]

0

[]

0

[ "PUB00097101" ]

[ "24388850" ]

[ "Gamete attachment requires GEX2 for successful fertilization in Arabidopsis." ]

[ 2014 ]

1

[]

0

null

[ "Aeriscardovia aeriphila", "Eukaryota" ]

[ 1, 626 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 2, 6 ]

3

true

Domain

GEX2, N-terminal Ig-like domain

Ig_GEX2_N

1

IPR056435

56,435

DNA polymerase delta/zeta catalytic subunit, N-terminal domain

DPOD/Z_N

Domain

6,825

false

This domain is found towards the N-terminal of DNA polymerase delta catalytic subunit (DPOD or POL3) and DNA polymerase zeta catalytic subunit (DPOZ or REV3) from Saccharomyces cerevisiae and similar eukaryotic protein sequences. POL3 is the catalytic component of DNA polymerase delta (DNA polymerase III), which partic...

[]

0

[ "PFAM" ]

[ "PF24055" ]

[ "POL3_N" ]

[ 6825 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-DDI-110314", "R-DDI-5651801", "R-DDI-5656169", "R-DDI-5696397", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-69091", "R-DDI-69166", "R-DDI-69183", "R-DME-110312", "R-DME-5655862", "R-DME-5656121", "R-DME-69166", "R-DME-69183", "R-HSA-110312", "R-HSA-110314", "R-HSA-174411...

[ "EC:2.7.7.7", "REACTOME:R-DDI-110314", "REACTOME:R-DDI-5651801", "REACTOME:R-DDI-5656169", "REACTOME:R-DDI-5696397", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-69091", "REACTOME:R-DDI-69166", "REACTOME:R-DDI-69183", "REACTOME:R-DME-110312", "REACTOME:R-DME-5655862", ...

81

[ "3iay", "6p1h", "6s1m", "6s1n", "6s1o", "6tny", "6tnz", "6v8p", "6v93", "7kc0", "7lxd", "7s0t", "8tlq", "8tlt", "9ekb" ]

15

[ "PUB00073198", "PUB00097416", "PUB00139057", "PUB00155804", "PUB00155805", "PUB00155806", "PUB00155807", "PUB00155808" ]

[ "16452144", "19718023", "11316789", "31488849", "31582849", "32111820", "32807989", "33203675" ]

[ "Saccharomyces cerevisiae polymerase zeta functions in mitochondria.", "Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.", "Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.", "Roles for DNA polymerase δ in initiating and terminating leading...

[ 2006, 2009, 2001, 2019, 2019, 2020, 2020, 2020 ]

8

[]

0

null

[ "Eukaryota", "Viruses", "viral metagenome" ]

[ 6809, 14, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 3, 2, 10, 5, 1, 5, 11, 2, 1, 9 ]

12

true

Domain

DNA polymerase delta/zeta catalytic subunit, N-terminal domain

DPOD/Z_N

1

IPR056437

56,437

ZNF598/HEL2, C2H2 zinc finger

Znf-C2H2_ZNF598/HEL2

Domain

3,708

false

This entry represents the C2H2-type zinc finger in Hel2 from Schizosaccharomyces pombe (also known as RQT complex subunit ubiquitin-protein ligase E3 subunit Rqt1) and E3 ubiquitin-protein ligase ZNF598 from humans. These proteins act as a ribosome collision sensors: specifically recognise and bind collided di-ribosome...

[]

0

[ "PFAM" ]

[ "PF23230" ]

[ "zf-C2H2_13" ]

[ 3708 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00073489", "PUB00092042", "PUB00092043", "PUB00095791", "PUB00101521", "PUB00151151", "PUB00155725", "PUB00155780", "PUB00158886", "PUB00158887", "PUB00160555" ]

[ "22570702", "28065601", "22751931", "30609991", "28223409", "32579943", "28757607", "29719242", "28685749", "30293783", "28943311" ]

[ "Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.", "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.", "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian developmen...

[ 2012, 2017, 2012, 2019, 2017, 2020, 2017, 2018, 2017, 2018, 2017 ]

11

[]

0

null

[ "Eukaryota" ]

[ 3708 ]

1

[ "Arabidopsis thaliana", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 2...

[ 13, 3, 1, 1, 6, 4, 1, 1, 18 ]

9

true

Domain

ZNF598/HEL2, C2H2 zinc finger

Znf-C2H2_ZNF598/HEL2

7

IPR056438

56,438

CTCF-like, C2H2 zinc finger

Znf-C2H2_CTCF

Domain

8,888

false

This entry represents C2H2 zinc finger domains found in multiple copies in a number of transcriptional regulators such as BCL11A, CTCF, ZNF142. CTCF is a multifunctional chromatin-binding factor that plays a central role in organising the three-dimensional structure of the genome. It binds to specific DNA sequences, fo...

[]

0

[ "PFAM" ]

[ "PF23611" ]

[ "zf-C2H2_16" ]

[ 8888 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5617472", "R-HSA-9700645", "R-HSA-9725370", "R-HSA-9933946", "R-HSA-9934037", "R-MMU-212436", "R-MMU-9933946", "R-MMU-9934037" ]

[ "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-9700645", "REACTOME:R-HSA-9725370", "REACTOME:R-HSA-9933946", "REACTOME:R-HSA-9934037", "REACTOME:R-MMU-212436", "REACTOME:R-MMU-9933946", "REACTOME:R-MMU-9934037" ]

8

[ "2d9h", "2eln", "2elq", "2ruz", "2rv2", "5k5h", "5k5i", "5k5j", "5kkq", "5t00", "5t0u", "5und", "5yef", "5yeg", "5yeh", "6h0g", "6ki6", "6u9q", "7w1m", "8dey", "8ssq", "8ssr", "8sss", "8sst", "8ssu", "8tho", "8tlo", "9e2u", "9e6r", "9e6s", "9e6t" ]

31

[ "PUB00155927", "PUB00155928", "PUB00160119", "PUB00160120", "PUB00160768", "PUB00160769", "PUB00160770", "PUB00160771" ]

[ "29606353", "8246978", "23644491", "12196208", "18347100", "18654629", "19322193", "12717433" ]

[ "Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.", "CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.", "Proteomic and bioinformatic analysis of mamm...

[ 2018, 1993, 2013, 2002, 2008, 2008, 2009, 2003 ]

8

[ "IPR013087" ]

[]

1

0

1

[ "Eukaryota" ]

[ 8888 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 20, 12, 21 ]

4

true

Domain

CTCF-like, C2H2 zinc finger

Znf-C2H2_CTCF

8

IPR056439

56,439

C3G9, VBS-like domain

VBS_C3G9

Domain

1,700

false

This domain is found in the uncharacterised protein C3G9.05 from S. pombe and related fungal proteins. It is predicted to adopt a four-helical up-and-down bundle with significant similarity to VBS-like domains.

[]

0

[ "PFAM" ]

[ "PF23742" ]

[ "VBS_C3G9" ]

[ 1700 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1700 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

C3G9, VBS-like domain

VBS_C3G9

7

IPR056440

56,440

GIR1-like, zinc ribbon domain

Zn-ribbon_GIR1

Domain

3,281

false

This domain is found in the Protein GL2-INTERACTING REPRESSOR 1 and 2 (GIR1/2), and Protein salt-induced and EIN3/EIL1-dependent 1 (SIED1) from Arabidopsis thaliana and related plant proteins. Proteins containing this domain are involved in the modulation of root hair development and act as negative regulators in this ...

[]

0

[ "PFAM" ]

[ "PF24747" ]

[ "Zn-ribbon_GIR1" ]

[ 3281 ]

1

[]

0

[]

0

[ "PUB00155290", "PUB00155291", "PUB00155292" ]

[ "25330213", "28526410", "28526412" ]

[ "Salt-induced stabilization of EIN3/EIL1 confers salinity tolerance by deterring ROS accumulation in Arabidopsis.", "Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development.", "Adaptor proteins GIR1 and GIR2. II. Interaction with the co-repressor TOPLESS...

[ 2014, 2017, 2017 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3281 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 23, 34 ]

3

true

Domain

GIR1-like, zinc ribbon domain

Zn-ribbon_GIR1

6

IPR056441

56,441

GLAA-B, beta-barrel domain II

Beta-barrel_GLAA-B_II

Domain

1,030

false

This entry represents the second β-barrel domain found in Alpha-1,3-galactosidase A-B (GLAA-B) from bacteria. This proteins share a domain architecture consisting of a core β-helix surrounded by two small β-barrel domains (domains I and II), which are involved in protein dimerisation. The α-helix of domain II folds ove...

[]

0

[ "PFAM" ]

[ "PF23764" ]

[ "Beta-barrel_GLAA-B_II" ]

[ 1030 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.22", "PWY-6527" ]

[ "EC:3.2.1.22", "METACYC:PWY-6527" ]

2

[ "7jw4", "7jwf", "8pvs", "8yk1", "8yk2", "8yk3", "9beh", "9beu", "9bev" ]

9

[ "PUB00155512", "PUB00155513" ]

[ "18227066", "33127644" ]

[ "Identification of a GH110 subfamily of alpha 1,3-galactosidases: novel enzymes for removal of the alpha 3Gal xenotransplantation antigen.", "The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens." ]

[ 2008, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA382M17", "metagenomes" ]

[ 1013, 9, 1, 7 ]

4

[]

0

true

Domain

GLAA-B, beta-barrel domain II

Beta-barrel_GLAA-B_II

6

IPR056442

56,442

Glucosamine inositolphosphorylceramide transferase 1, N-terminal

GINT1_N

Domain

2,688

false

This is the N-terminal domain of Glucosamine inositolphosphorylceramide transferase 1 from Arabidopsis thaliana (GINT1), a member of the Glycosyltransferase Family 64 that is involved in glycosylinositolphosphorylceramide and sphingolipid glycosylation [ ]. This domain is predicted to adopt a five-bladed β-propeller fo...

[]

0

[ "PFAM" ]

[ "PF24793" ]

[ "GINT1_N" ]

[ 2688 ]

1

[]

0

[]

0

[ "PUB00155637" ]

[ "29760197" ]

[ "GLUCOSAMINE INOSITOLPHOSPHORYLCERAMIDE TRANSFERASE1 (GINT1) Is a GlcNAc-Containing Glycosylinositol Phosphorylceramide Glycosyltransferase." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 61, 1616, 988, 23 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 5, 14 ]

3

true

Domain

Glucosamine inositolphosphorylceramide transferase 1, N-terminal

GINT1_N

7

IPR056443

56,443

C962R-like, N-terminal AEP domain

AEP_C962R

Domain

768

false

This AEP domain is found N-terminal in the C962R protein from African swine fever virus and related proteins. C962R protein possesses both DNA polymerisation and DNA unwinding activities. This protein adopts a ring-shaped conformation and the N-terminal AEP domain is responsible for the DNA polymerisation activity [ ]....

[]

0

[ "PFAM" ]

[ "PF23162" ]

[ "AEP_C962R" ]

[ 768 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "8iqb", "8iqc", "8iqd", "8iqh", "8iqi", "8wvz", "8ww6", "8ww7", "8ww8", "8ww9", "8wwa" ]

11

[ "PUB00155487" ]

[ "37587714" ]

[ "Structures and implications of the C962R protein of African swine fever virus." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 232, 2, 266, 268 ]

4

[ "Zea mays" ]

[ 4 ]

1

true

Domain

C962R-like, N-terminal AEP domain

AEP_C962R

4

IPR056444

56,444

GRF-like, zinc ribbon domain

Zn_ribbon_GRF_2

Domain

385

false

This domain is found in a group of uncharacterised proteins mainly from fungi. It is predicted to adopt a zinc ribbon fold and it is closely related to GRF type zinc fingers ( ).

[]

0

[ "PFAM" ]

[ "PF23549" ]

[ "Zn_ribbon_GRF_2" ]

[ 385 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 385 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

GRF-like, zinc ribbon domain

Zn_ribbon_GRF_2

8

IPR056445

56,445

HPS5, TPR domain

TPR_HPS5

Domain

1,353

false

This entry represents the TPR domain found at the C-terminal of HPS5 protein from vertebrates, a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2) [ ] and which has a role in the endo-lysosomal dynamics of skin fibroblasts [ ]. Its mutation or absence has been linked to Hermansky-Pudlak type...

[]

0

[ "PFAM" ]

[ "PF23758" ]

[ "TPR_HPS5" ]

[ 1353 ]

1

[]

0

[]

0

[ "PUB00043624", "PUB00155526", "PUB00155527" ]

[ "15030569", "28296950", "18544035" ]

[ "Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.", "Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.", "Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics." ]

[ 2004, 2017, 2008 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1353 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 9, 5 ]

4

true

Domain

HPS5, TPR domain

TPR_HPS5

4

IPR056446

56,446

HPS5, TPR domain, insects

TPR_HPS5_insects

Domain

253

false

This entry represents the TPR domain found at the C-terminal of HPS5 protein from insects, a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2) [ ]. Its mutation or absence has been linked to eye-colour mutations [ ]. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF23757" ]

[ "TPR_HPS5_insect" ]

[ 253 ]

1

[]

0

[]

0

[ "PUB00043624", "PUB00085365" ]

[ "15030569", "9714595" ]

[ "Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.", "Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery." ]

[ 2004, 1998 ]

2

[]

0

null

[ "Pterygota" ]

[ 253 ]

1

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Domain

HPS5, TPR domain, insects

TPR_HPS5_insects

6

IPR056447

56,447

DNA polymerase zeta catalytic subunit, N-terminal

REV3_N

Domain

3,969

false

This domain is found at the N-terminal end of DNA polymerase zeta catalytic subunit (REV3) from Saccharomyces cerevisiae and similar eukaryotic sequences. REV3 is a nonessential DNA polymerase involved in DNA repair, mitochondrial DNA repair and translesion synthesis. This domain shows a mainly β-configuration [ , , ]....

[]

0

[ "PFAM" ]

[ "PF24065" ]

[ "REV3_N" ]

[ 3969 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.7.7", "R-DME-110312", "R-DME-5655862", "R-DME-5656121", "R-HSA-110312", "R-HSA-5655862", "R-HSA-5656121", "R-MMU-110312", "R-MMU-5655862", "R-MMU-5656121", "R-SCE-110312", "R-SCE-5655862", "R-SCE-5656121" ]

[ "EC:2.7.7.7", "REACTOME:R-DME-110312", "REACTOME:R-DME-5655862", "REACTOME:R-DME-5656121", "REACTOME:R-HSA-110312", "REACTOME:R-HSA-5655862", "REACTOME:R-HSA-5656121", "REACTOME:R-MMU-110312", "REACTOME:R-MMU-5655862", "REACTOME:R-MMU-5656121", "REACTOME:R-SCE-110312", "REACTOME:R-SCE-5655862"...

13

[ "6v8p", "6v93", "7lxd", "7s0t", "8tlq", "8tlt" ]

6

[ "PUB00155806", "PUB00155807", "PUB00155826" ]

[ "32111820", "32807989", "34174285" ]

[ "Structure of the processive human Pol δ holoenzyme.", "Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis.", "Cryo-EM reveals conformational flexibility in apo DNA polymerase ζ." ]

[ 2020, 2020, 2021 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3969 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 3, 1, 3, 2, 1, 3, 3, 1, 7 ]

11

true

Domain

DNA polymerase zeta catalytic subunit, N-terminal

REV3_N

5

IPR056448

56,448

Cadherin-related hmr-1, EGF domain

EGF_Hmr-1

Domain

159

false

This domain is found towards the C-terminal of Cadherin-related hmr-1 from Caenorhabditis elegans and related nematode sequences, a calcium-dependent cell adhesion protein required for adherens junction assembly and connecting adherens junctions to the cytoskeleton [ ].

[]

0

[ "PFAM" ]

[ "PF24613" ]

[ "EGF_Hmr-1" ]

[ 159 ]

1

[]

0

[]

0

[ "PUB00154467" ]

[ "26412237" ]

[ "ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions." ]

[ 2015 ]

1

[]

0

null

[ "Nematoda" ]

[ 159 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Cadherin-related hmr-1, EGF domain

EGF_Hmr-1

1

IPR056449

56,449

Capsid protein Vp20

Vp20_capsid

Domain

14

false

This entry represents the capsid protein Vp20 from apple-latent spherical virus (ALSV) and related picorna-like plant viruses. This protein is encoded in a polyprotein that is cleaved into three capsid proteins, Vp25, Vp20 and Vp24, which all have jellyroll folds and form one protomer; 60 copies of this unit compose on...

[]

0

[ "PFAM" ]

[ "PF23370" ]

[ "Vp20_capsid" ]

[ 14 ]

1

[]

0

[ "7chk" ]

1

[ "PUB00155910" ]

[ "32887929" ]

[ "Apple latent spherical virus structure with stable capsid frame supports quasi-stable protrusions expediting genome release." ]

[ 2020 ]

1

[]

0

null

[ "Cheravirus" ]

[ 14 ]

1

[]

0

true

Domain

Capsid protein Vp20

Vp20_capsid

9

IPR056450

56,450

DNA repair protein RAD5A, UBA domain

UBA_RAD5A

Domain

790

false

This is the UBA domain found at the N-terminal of DNA repair protein RAD5A from Arabidopsis thaliana and similar plant sequences. RAD5A functions in error-free postreplication DNA repair or DNA-damage tolerance (DTT) pathway [ , ]. It is required for homologous recombination (HR) induced by DNA double-strand break (DSB...

[]

0

[ "PFAM" ]

[ "PF24559" ]

[ "UBA_RAD5A" ]

[ 790 ]

1

[]

0

[]

0

[ "PUB00155899", "PUB00155900" ]

[ "18310306", "21549648" ]

[ "A homolog of ScRAD5 is involved in DNA repair and homologous recombination in Arabidopsis.", "RAD5a and REV3 function in two alternative pathways of DNA-damage tolerance in Arabidopsis." ]

[ 2008, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 790 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 3, 10 ]

3

true

Domain

DNA repair protein RAD5A, UBA domain

UBA_RAD5A

4

IPR056451

56,451

DNA repair protein rhp7, treble clef domain

Znf_Tbcl_Rhp7

Domain

1,497

false

This domain is found in the DNA repair protein rhp7 and related fungal proteins. Rhp7 is involved in nucleotide excision repair. It is forming a complex with Rhp16 which was shown to be essential for global genome repair in S.pombe [ ]. The domain represented by this entry is predicted to adopt a treble clef fold. It c...

[]

0

[ "PFAM" ]

[ "PF23550" ]

[ "zf_Tbcl_Rhp7" ]

[ 1497 ]

1

[]

0

[]

0

[ "PUB00138394" ]

[ "10446227" ]

[ "Characterization of the rhp7(+) and rhp16(+) genes in Schizosaccharomyces pombe." ]

[ 1999 ]

1

[]

0

null

[ "Dikarya" ]

[ 1497 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

DNA repair protein rhp7, treble clef domain

Znf_Tbcl_Rhp7

6

IPR056452

56,452

DNA topoisomerase 3-beta, zinc ribbon domain

Zn_ribbon_TOP3B

Domain

2,662

false

This domain is found in human DNA topoisomerase 3-beta (TOP3B) and related proteins predominantly from animals and plants. TOP3B, a recently identified member of the topoisomerase superfamily, is essential for chromosome stability, including in cancer cells [ ]. The domain represented by this entry is predicted to adop...

[]

0

[ "PFAM" ]

[ "PF23546" ]

[ "Zn_ribbon_TOP3B" ]

[ 2662 ]

1

[ "EC" ]

[ "5.6.2.1" ]

[ "EC:5.6.2.1" ]

1

[ "9cah" ]

1

[ "PUB00155941" ]

[ "20950730" ]

[ "Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2662 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 2, 3, 4, 4, 2, 2, 8 ]

9

true

Domain

DNA topoisomerase 3-beta, zinc ribbon domain

Zn_ribbon_TOP3B

9

IPR056453

56,453

DNAJC9, HTH domain

HTH_DNAJC9

Domain

4,542

false

This domain is found in human DnaJ homolog subfamily C member 9 (DNAJC9) and related eukaryotic proteins. DNAJC9 acts as a dual histone chaperone and heat-shock co-chaperone [ ]. This protein was shown to also assemble histones onto DNA in vitro [ ]. The domain represented in this entry has a weak similarity to helix-t...

[]

0

[ "PFAM" ]

[ "PF23302" ]

[ "HTH_DNAJC9" ]

[ 4542 ]

1

[]

0

[]

0

[ "PUB00155663" ]

[ "33857403" ]

[ "DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network." ]

[ 2021 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4542 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 8, 1, 1, 2, 2, 2, 1, 2, 5, 1, 32 ]

11

true

Domain

DNAJC9, HTH domain

HTH_DNAJC9

8

IPR056454

56,454

IP5PC-F, beta-propeller domain

Beta-prop_IP5PC_F

Domain

2,452

false

This entry represents the β-propeller domain found in plant inositol polyphosphate 5-phosphatases (IP5P), including Type I IP5P12/IP5PC and IP5P13/IP5PD, Type II IP5P14/IP5PE and IP5P15/IP5PF from Arabidopsis thaliana. In the case of IP5P13, the β-propeller domain interacts with the sucrose non-fermenting-1-related kin...

[]

0

[ "PFAM" ]

[ "PF23754" ]

[ "Beta-prop_IP5PC_F" ]

[ 2452 ]

1

[]

0

[]

0

[ "PUB00134029", "PUB00155531" ]

[ "18931139", "31426386" ]

[ "Interaction of the WD40 domain of a myoinositol polyphosphate 5-phosphatase with SnRK1 links inositol, sugar, and stress signaling.", "The Function of Inositol Phosphatases in Plant Tolerance to Abiotic Stress." ]

[ 2008, 2019 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2440, 12 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 11, 33 ]

3

true

Domain

IP5PC-F, beta-propeller domain

Beta-prop_IP5PC_F

4

IPR056455

56,455

IP5PC-F, immunoglobulin-like domain

Ig-like_IP5PC_F

Domain

1,618

false

This entry represents the immunoglobulin-like domain found in plant inositol polyphosphate 5-phosphatases Type I IP5P12/IP5PC and IP5P13/IP5PD and Type II IP5P14/IP5PE and IP5PF/IP5PF from Arabidopsis thaliana. The function of this domain is unknown. IP5Ps have different functions, including the degradation of phosphoi...

[]

0

[ "PFAM" ]

[ "PF23755" ]

[ "Ig-like_IP5PC_F" ]

[ 1618 ]

1

[]

0

[]

0

[ "PUB00155531" ]

[ "31426386" ]

[ "The Function of Inositol Phosphatases in Plant Tolerance to Abiotic Stress." ]

[ 2019 ]

1

[]

0

null

[ "Streptophyta" ]

[ 1618 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 24, 9, 32 ]

3

true

Domain

IP5PC-F, immunoglobulin-like domain

Ig-like_IP5PC_F

1

IPR056456

56,456

IFT80, second beta-propeller domain

Beta-prop_IFT80_2nd

Domain

2,192

false

This entry represents the second β-propeller domain of the Intraflagellar transport protein 80 homolog (IFT80) from human and related proteins. IFT80 is a component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. It is required for ini...

[]

0

[ "PFAM" ]

[ "PF23335" ]

[ "Beta-prop_IFT80_2nd" ]

[ 2192 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5620924", "R-MMU-5620924", "R-RNO-5620924" ]

[ "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5620924", "REACTOME:R-RNO-5620924" ]

3

[ "5n4a", "8bd7", "8ruy" ]

3

[ "PUB00155530" ]

[ "29658880" ]

[ "Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis." ]

[ 2018 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2192 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 3, 1, 2 ]

6

true

Domain

IFT80, second beta-propeller domain

Beta-prop_IFT80_2nd

5

IPR056457

56,457

DOP1-like, C-terminal

DOP1_C

Domain

5,527

false

This entry represents the C-terminal region of of DOP1 (A/B) from vertebrates, DOP1 from E. nidulans and S. cerevisiae, DOP1 homolog from D. melanogaster and C. elegans ortholog (pad-1) and other homologous proteins in animals and fungi. This domain consists of TPRs repeats. DOP1 is the founding member of the Dopey fam...

[]

0

[ "PFAM" ]

[ "PF24598" ]

[ "DOP1_C" ]

[ 5527 ]

1

[]

0

[]

0

[ "PUB00009850", "PUB00068242", "PUB00155030" ]

[ "10931277", "16301316", "30213940" ]

[ "Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.", "Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.", "SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A ...

[ 2000, 2006, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5527 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 12, 2, 4, 8, 1, 6, 1, 1 ]

9

true

Domain

DOP1-like, C-terminal

DOP1_C

2

IPR056458

56,458

DOP1-like, middle TPR domain

TPR_DOP1_M

Domain

4,580

false

This entry represents a domain found at the middle region of DOP1 (A/B) from vertebrates, DOP1 from S.cerevisiae and E. nidulans, DOP1 homolog from D. melanogaster and other homologous proteins from animals and fungi. This domain consists of TPRs repeats. DOP1 is the founding member of the Dopey family and is required ...

[]

0

[ "PFAM" ]

[ "PF24597" ]

[ "TPR_DOP1_M" ]

[ 4580 ]

1

[]

0

[]

0

[ "PUB00009850", "PUB00068242", "PUB00155030" ]

[ "10931277", "16301316", "30213940" ]

[ "Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.", "Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.", "SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A ...

[ 2000, 2006, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4580 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 12, 2, 5, 6, 1, 11, 1 ]

7

true

Domain

DOP1-like, middle TPR domain

TPR_DOP1_M

9

IPR056459

56,459

DOP1-like, TPR domain

TPR_DOP1

Domain

4,250

false

This entry represents a domain found near the C-terminal end of DOP1 (A/B) from vertebrates, DOP1 homolog from Drosophila melanogaster and Caenorhabditis elegans ortholog (pad-1). DOP1 homologues are found in mammals, where they may play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A a...

[]

0

[ "PFAM" ]

[ "PF24601" ]

[ "TPR_DOP1" ]

[ 4250 ]

1

[]

0

[]

0

[ "PUB00009850", "PUB00068242", "PUB00155030" ]

[ "10931277", "16301316", "30213940" ]

[ "Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.", "Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.", "SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A ...

[ 2000, 2006, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4250 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 12, 2, 5, 9, 1, 10 ]

7

true

Domain

DOP1-like, TPR domain

TPR_DOP1

6

IPR056460

56,460

DUF1512, N-terminal domain

DUF1512_N

Domain

267

false

This domain is found at the N-terminal end of several archaeal sequences of around 370 residues in length. The function of this group of proteins is unknown.

[]

0

[ "PFAM" ]

[ "PF07431" ]

[ "DUF1512" ]

[ 267 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Anoplophora glabripennis", "Archaea", "ecological metagenomes" ]

[ 1, 249, 17 ]

3

[]

0

true

Domain

DUF1512, N-terminal domain

DUF1512_N

6

IPR056461

56,461

DUF1512, C-terminal domain

DUF1512_C

Domain

261

false

This entry includes archaeal proteins of around 370 residues in length. This entry corresponds to the C-terminal domain. The function of this group of proteins is unknown. This domain shows structural similarity to peptidyl tRNA hydrolase enzymes.

[]

0

[ "PFAM" ]

[ "PF23542" ]

[ "DUF1512_C" ]

[ 261 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 245, 16 ]

2

[]

0

true

Domain

DUF1512, C-terminal domain

DUF1512_C

2

IPR056462

56,462

Glycerol-3-phosphate acyltransferase RAM2/GPAT1-8, HAD-like domain

HAD_RAM2/GPAT1-8

Domain

5,489

false

This domain is found at the N-terminal of Glycerol-3 -phosphate acyltransferase RAM2 from Medicago truncatula, GPAT1-8 from Arabidopsis and related plant proteins which esterify the acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis [ , ]. RAM2 is involved in the product...

[]

0

[ "PFAM" ]

[ "PF23270" ]

[ "HAD_RAM2_N" ]

[ 5489 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.15", "PWY-5667", "PWY-6453", "PWY-7411", "PWY-7587", "PWY-8051", "PWY-8053", "PWY-8055" ]

[ "EC:2.3.1.15", "METACYC:PWY-5667", "METACYC:PWY-6453", "METACYC:PWY-7411", "METACYC:PWY-7587", "METACYC:PWY-8051", "METACYC:PWY-8053", "METACYC:PWY-8055" ]

8

[]

0

[ "PUB00155640", "PUB00158856", "PUB00158857" ]

[ "23122843", "12897259", "20551224" ]

[ "A common signaling process that promotes mycorrhizal and oomycete colonization of plants.", "Arabidopsis AtGPAT1, a member of the membrane-bound glycerol-3-phosphate acyltransferase gene family, is essential for tapetum differentiation and male fertility.", "A distinct type of glycerol-3-phosphate acyltransfer...

[ 2012, 2003, 2010 ]

3

[]

0

null

[ "Embryophyta" ]

[ 5489 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 35, 66, 41 ]

3

true

Domain

Glycerol-3-phosphate acyltransferase RAM2/GPAT1-8, HAD-like domain

HAD_RAM2/GPAT1-8

5

IPR056463

56,463

DUF7373, C-terminal

DUF7373_C

Domain

1,177

false

This domain is found C-terminal in uncharacterised proteins from actinomycetes. It is predicted to adopt a seven-stranded antiparallel β-sheet with similarity to Mog1p/PsbP-like domains. Some proteins containing this domain have a lipoprotein attachment motif at the N terminus suggesting they may be associated with the...

[]

0

[ "PFAM" ]

[ "PF24092" ]

[ "DUF7373_C" ]

[ 1177 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 1177 ]

1

[]

0

true

Domain

DUF7373, C-terminal

DUF7373_C

1

IPR056464

56,464

DotM, C-terminal cytoplasmic domain

DotM_C

Domain

1,110

false

This entry represents the C-terminal cytoplasmic domain of DotM from Legionella pneumophila and related proteins found mainly in gammaproteobacteria. DotM is a component of Type 4B secretion (T4BS) system that translocates over 300 effectors into the host cell during infection. The DotM cytoplasmic domain adopts an α-h...

[]

0

[ "PFAM" ]

[ "PF23127" ]

[ "DotM_C" ]

[ 1110 ]

1

[]

0

[ "5x1u", "6exa", "6exb", "6exc", "6exd", "6exe", "6sz9", "7ovb" ]

8

[ "PUB00100787", "PUB00105402" ]

[ "32513920", "29410427" ]

[ "Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.", "Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system." ]

[ 2020, 2018 ]

2

[]

0

null

[ "Bacteria", "Plasmid R64", "Trichuris trichiura", "metagenomes" ]

[ 1101, 1, 1, 7 ]

4

[]

0

true

Domain

DotM, C-terminal cytoplasmic domain

DotM_C

6

IPR056465

56,465

DotY

Family

75

false

This entry represent the type 4 apparatus protein DotY from Legionella pneumophila and related proteins from gammaproteobacteria. DotY is a component of Type 4B secretion (T4BS) system that translocates over 300 effectors into the host cell during infection. This protein is part of a subcomplex which recruits effector ...

[]

0

[ "PFAM" ]

[ "PF23131" ]

[ "DotY" ]

[ 75 ]

1

[]

0

[ "6sz9", "7ovb", "7ups" ]

3

[ "PUB00100787", "PUB00153336" ]

[ "32513920", "34816517" ]

[ "Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.", "Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Legionellaceae" ]

[ 75 ]

1

[]

0

true

Family

DotY

4

IPR056466

56,466

Guanine nucleotide exchange factor DBS-like, spectrin-like

Spectrin_DBS

Domain

7,361

false

This spectrin-like domain is found in human Guanine nucleotide exchange factor DBS (MCF2L) and similar sequences mainly found in animals. MCF2L catalyses guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signalling pathways [ , , ].

[]

0

[ "PFAM" ]

[ "PF23289" ]

[ "Spectrin_5" ]

[ 7361 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-193634", "R-HSA-193648", "R-HSA-416482", "R-HSA-8980692", "R-HSA-9013026", "R-HSA-9013106", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013408", "R-HSA-9013423", "R-MMU-193648", "R-MMU-416482", "R-MMU-8980692", "R-MMU-9013026", "R-MMU-9013106", "R-MMU-9013148", ...

[ "REACTOME:R-HSA-193634", "REACTOME:R-HSA-193648", "REACTOME:R-HSA-416482", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013026", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9013423", "REACTOME:R...

26

[]

0

[ "PUB00022066", "PUB00026873", "PUB00056751" ]

[ "12006984", "11889037", "17000758" ]

[ "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.", "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.", "Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Db...

[ 2002, 2002, 2006 ]

3

[]

0

null

[ "Eukaryota" ]

[ 7361 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 138, 16, 23, 20 ]

5

true

Domain

Guanine nucleotide exchange factor DBS-like, spectrin-like

Spectrin_DBS

8

IPR056467

56,467

GTF3C1, extended winged-helix domain

eWH_GTF3C1

Domain

2,980

false

This is the extended winged-helix domain (eWH) of human General transcription factor 3C polypeptide 1 (GTF3C1), a component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs.

[]

0

[ "PFAM" ]

[ "PF24101" ]

[ "WHD_GTF3C1" ]

[ 2980 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061", "R-MMU-76066", "R-RNO-76061", "R-RNO-76066" ]

[ "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-RNO-76061", "REACTOME:R-RNO-76066" ]

7

[ "8cli", "8clj", "8clk", "8cll" ]

4

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2980 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 2, 3, 1, 3, 7, 6, 8, 48 ]

9

true

Domain

GTF3C1, extended winged-helix domain

eWH_GTF3C1

1

IPR056468

56,468

Guanine-nucleotide exchange factor YEL1, PH domain

PH_GEF_YEL1

Domain

75

false

This entry represents a PH domain found in the YEL1 family proteins. The YEL1 family comprises guanine-nucleotide exchange factors (GEFs) for ARF3, a small GTPase involved in vesicle transport and actin cytoskeleton organisation. Members of the YEL1 family are essential for the correct localisation of ARF3 to specific ...

[]

0

[ "PFAM" ]

[ "PF23633" ]

[ "PH_GEF_YEL1" ]

[ 75 ]

1

[]

0

[]

0

[ "PUB00158903", "PUB00158904" ]

[ "17786213", "18208507" ]

[ "Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6.", "Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis." ]

[ 2007, 2008 ]

2

[]

0

null

[ "Saccharomycotina" ]

[ 75 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Guanine-nucleotide exchange factor YEL1, PH domain

PH_GEF_YEL1

2

IPR056469

56,469

Half a barrel domain

HAB_dom

Domain

48

false

This entry represents a region found in proteins possibly related to plasmid partitioning. This domain is composed of two copies of this region each of which forms three strands of a 6-stranded β-barrel. This entry is named the HAB region for Half A Barrel. The β-barrel is capped at one end by two short β-strands, one ...

[]

0

[ "PFAM" ]

[ "PF24721" ]

[ "HAB" ]

[ 48 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 48 ]

1

[]

0

true

Domain

Half a barrel domain

HAB_dom

9

IPR056471

56,471

HD-CE

Domain

871

false

This entry represents an HD-like domain predicted to act as effector in multiples antiviral immunity system by targeting nucleotides [ ].

[]

0

[ "PFAM" ]

[ "PF24391" ]

[ "HD-CE" ]

[ 871 ]

1

[]

0

[]

0

[ "PUB00155486" ]

[ "37889040" ]

[ "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]

[ 2023 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Pezizomycotina", "metagenomes" ]

[ 64, 780, 3, 24 ]

4

[]

0

true

Domain

HD-CE

6

IPR056472

56,472

Head completion protein

HCP

Family

833

false

This entry represents the Head completion protein (HCP) found in T5-like bacteriophages [ ]. HCP forms dodecameric ring assembly and is a component of the bacteriophage neck. It holds the portal protein PrtP dodecameric ring and connects with the trimeric layer of the tail tube via contacts with the tail completion (TC...

[]

0

[ "PFAM" ]

[ "PF24163" ]

[ "HCP" ]

[ 833 ]

1

[]

0

[ "8hqo", "9ilp", "9imv" ]

3

[ "PUB00096391", "PUB00155646" ]

[ "24198424", "38081816" ]

[ "Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.", "Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers." ]

[ 2014, 2023 ]

2

[]

0

null

[ "Bacteria", "Halobacteriales", "Viruses", "metagenomes" ]

[ 475, 3, 298, 57 ]

4

[]

0

true

Family

Head completion protein

HCP

9

IPR056473

56,473

Utp10/HEAT1, HEAT-repeats domain

HEAT_Utp10/HEAT1

Domain

4,218

false

This entry represents a HEAT-repeats domain found in HEATR1, Utp10 and similar eukaryotic proteins. Proteins in this entry contain an armadillo-type fold, and a BP28, C-terminal domain. It includes HEAT repeat -containing protein 1 (HEATR1) from human and its orthologues from fungi, U3 small nucleolar RNA-associated pr...

[]

0

[ "PFAM" ]

[ "PF23243" ]

[ "HEAT_HEATR1" ]

[ 4218 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6791226", "R-DME-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-CEL-6791226", "REACTOME:R-DME-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[ "5jpq", "5oql", "5wlc", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6nd4", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "7ajt", "7aju", "7d4i", "7d5s", "7d5t", "7d63", "7mq8", "7mq9"...

47

[ "PUB00008496", "PUB00090010", "PUB00090011", "PUB00151110", "PUB00158858" ]

[ "12068309", "17652137", "17699751", "34516797", "38225354" ]

[ "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.", "Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation.", "Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription...

[ 2002, 2007, 2007, 2021, 2024 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4218 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 5, 1, 8, 3, 1, 2, 3, 1, 1, 6 ]

12

true

Domain

Utp10/HEAT1, HEAT-repeats domain

HEAT_Utp10/HEAT1

8

IPR056474

56,474

Helicase SEN1, beta-barrel domain

SEN1_barrel

Domain

2,274

false

This domain is found in the yeast Helicase SEN1 and related proteins from fungi and some uncharacterised plant sequences. SEN1 is an ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nu...

[]

0

[ "PFAM" ]

[ "PF23576" ]

[ "SEN1_barrel" ]

[ 2274 ]

1

[]

0

[ "5mzn", "6i59", "8fth", "8ftk", "8ftm", "8ram", "8ran", "8rao", "8rap" ]

9

[ "PUB00095913", "PUB00160034", "PUB00160035", "PUB00160036" ]

[ "28408439", "11565036", "16507362", "23177741" ]

[ "Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.", "RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts.", "Regulation of yeast NRD1 expression by premature transcription termination.", "Kinetic competition be...

[ 2017, 2001, 2006, 2013 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2274 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 1, 1, 2, 12 ]

6

true

Domain

Helicase SEN1, beta-barrel domain

SEN1_barrel

7

IPR056475

56,475

Hemicentin/VWA7, galactose-binding domain-like

GBD_Hemicentin/VWA7

Domain

3,364

false

This entry represents a galactose-binding domain-like found in Hemicentin and Willebrand factor A domain-containing protein 7 (VWA7). HMCN1 is involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibres and broadening, flattening and elongat...

[]

0

[ "PFAM" ]

[ "PF23560" ]

[ "GBD_Hemicentin" ]

[ 3364 ]

1

[]

0

[]

0

[ "PUB00057248", "PUB00083205", "PUB00083207", "PUB00155634", "PUB00158859", "PUB00158860", "PUB00160748" ]

[ "12388743", "21215633", "24951538", "28196094", "29488390", "34504132", "11261934" ]

[ "Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.", "A secreted protein promotes cleavage furrow maturation during cytokinesis.", "Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration.", "Inn...

[ 2002, 2011, 2014, 2017, 2018, 2021, 2001 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 89, 3271, 4 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 17, 10, 6, 6 ]

5

true

Domain

Hemicentin/VWA7, galactose-binding domain-like

GBD_Hemicentin/VWA7

1

IPR056476

56,476

Capsid protein Vp24

Vp24_capsid

Domain

10

false

This entry represents the capsid Vp24 protein from apple-latent spherical virus (ALSV) and related picorna-like plant viruses. This protein is encoded in a polyprotein that is cleaved into three proteins, Vp25, Vp20 and Vp24 which all have jellyroll fold and form one protomer; 60 copies of this unit compose one virion....

[]

0

[ "PFAM" ]

[ "PF23371" ]

[ "Vp24_capsid" ]

[ 10 ]

1

[]

0

[ "7chk" ]

1

[ "PUB00155910" ]

[ "32887929" ]

[ "Apple latent spherical virus structure with stable capsid frame supports quasi-stable protrusions expediting genome release." ]

[ 2020 ]

1

[]

0

null

[ "Cheravirus" ]

[ 10 ]

1

[]

0

true

Domain

Capsid protein Vp24

Vp24_capsid

4

IPR056477

56,477

Capsid protein Vp25

Vp25_capsid

Domain

15

false

This entry represents the capsid Vp24 protein from apple-latent spherical virus (ALSV) and related picorna-like plant viruses. This protein is encoded in a polyprotein that is cleaved into three capsid proteins, Vp25, Vp20 and Vp24, which all have jellyroll folds and form one protomer; 60 copies of this unit compose on...

[]

0

[ "PFAM" ]

[ "PF23369" ]

[ "Vp25_capsid" ]

[ 15 ]

1

[]

0

[ "7chk" ]

1

[ "PUB00155910" ]

[ "32887929" ]

[ "Apple latent spherical virus structure with stable capsid frame supports quasi-stable protrusions expediting genome release." ]

[ 2020 ]

1

[]

0

null

[ "Cheravirus" ]

[ 15 ]

1

[]

0

true

Domain

Capsid protein Vp25

Vp25_capsid

3

IPR056479

56,479

CARF-associated, helix-turn-helix domain

CARF-assoc_HTH

Domain

7

false

This entry represents a presumed helix-turn-helix (HTH) domain found at the C terminus of a group of CARF-containing archaeal proteins. This domain is found associated with .

[]

0

[ "PFAM" ]

[ "PF24744" ]

[ "CARF-assoc_HTH" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 7 ]

1

[]

0

true

Domain

CARF-associated, helix-turn-helix domain

CARF-assoc_HTH

7

IPR056480

56,480

Hfq-like domain

Phage_Hfq_dom

Domain

50

false

This entry includes phage proteins that contain a central Hfq-like domain. This suggests that this protein may have an RNA binding function. AlphaFold prediction suggests a confident homohexameric structure. This entry represents a hypothetical protein found in several mycobacteriophages, including Bxz1, Mangeria, Dere...

[]

0

[ "PFAM" ]

[ "PF23874" ]

[ "Phage_Hfq" ]

[ 50 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes" ]

[ 50 ]

1

[]

0

true

Domain

Hfq-like domain

Phage_Hfq_dom

3

IPR056482

56,482

Krimper, first tudor domain

Tudor_krimper_1st

Domain

73

false

This entry represents the first Tudor domain found in Protein krimper (also known as Tudor domain-containing protein krimp) from Drosophila melanogaster and similar fly proteins. Krimper is required for ping-pong piRNA amplification and is capable of both self-interactions and binding of the two PIWI proteins: Aub and ...

[]

0

[ "PFAM" ]

[ "PF24047" ]

[ "Tudor_krimper_1st" ]

[ 73 ]

1

[]

0

[ "7cfb", "7cfc" ]

2

[ "PUB00155894", "PUB00155895", "PUB00155896" ]

[ "26295961", "17346786", "34210982" ]

[ "Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.", "Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.", "Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to as...

[ 2015, 2007, 2021 ]

3

[]

0

null

[ "Diptera" ]

[ 73 ]

1

[ "Drosophila melanogaster" ]

[ 33 ]

1

true

Domain

Krimper, first tudor domain

Tudor_krimper_1st

3

IPR056483

56,483

Histidine N-acetyltransferase, C-terminal

Hisat_C

Domain

950

false

This entry represents the C-terminal domain of Histidine N-acetyltransferase HISAT from ectothermic vertebrates and the orthologue from human, NAT16. HISAT is responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates [ ]. NAT16, unlike fish HISAT, ...

[]

0

[ "PFAM" ]

[ "PF24066" ]

[ "Hisat_C" ]

[ 950 ]

1

[ "EC" ]

[ "2.3.1.33" ]

[ "EC:2.3.1.33" ]

1

[ "9emd", "9emo", "9emp", "9emt", "9en3" ]

5

[ "PUB00155660" ]

[ "24121108" ]

[ "An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for Nα-acetylhistidine synthesis." ]

[ 2014 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 950 ]

1

[ "Danio rerio", "Homo sapiens" ]

[ 3, 1 ]

2

true

Domain

Histidine N-acetyltransferase, C-terminal

Hisat_C

7

IPR056484

56,484

Histone acetyltransferase p300/CREBBP, PHD domain

PHD_P300

Domain

5,533

false

This domain is found in human Histone acetyltransferase p300 (EP300), Histone lysine acetyltransferase CREBBP and similar animal proteins. EP300 functions as a histone acetyltransferase and regulates transcription via chromatin remodelling [ , ]. Histone lysine acetyltransferase CREBBP acetylates histones, giving a spe...

[]

0

[ "PFAM" ]

[ "PF23570" ]

[ "PHD_P300" ]

[ 5533 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.3.1.-", "2.3.1.48", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710"...

[ "EC:2.3.1.-", "EC:2.3.1.48", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", ...

350

[ "4bhw", "4n3w", "4n4f", "5i8b", "5i8g", "5lkt", "5lku", "5lkx", "5lkz", "5u7g", "5xzc", "6alb", "6gyr", "6gyt", "6k4n", "7ss8", "7ssk", "7vhy", "7vhz", "7vi0", "7w9v", "8cmz", "8cn0", "8cna", "8cnb", "8cnd", "8gzc", "8hag", "8hah", "8hai", "8haj", "8hak"...

36

[ "PUB00074827", "PUB00079449", "PUB00100520", "PUB00155789", "PUB00155790", "PUB00155791", "PUB00158861", "PUB00158862", "PUB00158863", "PUB00158864" ]

[ "23934153", "24361270", "30540930", "27190605", "28630323", "31314496", "21131905", "23415232", "24616510", "35675826" ]

[ "Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.", "Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP.", "SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Met...

[ 2013, 2014, 2018, 2016, 2017, 2019, 2011, 2013, 2014, 2022 ]

10

[]

0

null

[ "Eukaryota" ]

[ 5533 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 62, 4, 7, 7, 7 ]

6

true

Domain

Histone acetyltransferase p300/CREBBP, PHD domain

PHD_P300

4

IPR056485

56,485

KRIT1, ARM-repeats domain

ARM_KRIT1

Domain

1,975

false

KRIT1, also known as CCM1, a Rap1-binding protein, is expressed in endothelial cells where it is present in cell-cell junctions and associated with junctional proteins [ ]. Together with CCM2/MGC4607 and CCM3/PDCD10, KRIT1 constitutes a set of proteins whose mutations are found in cerebral cavernous malformations, char...

[]

0

[ "PFAM" ]

[ "PF24521" ]

[ "Ank_KRIT1" ]

[ 1975 ]

1

[]

0

[ "5d68" ]

1

[ "PUB00091843", "PUB00091844" ]

[ "17954608", "22577140" ]

[ "KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.", "Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)." ]

[ 2007, 2012 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1975 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 11, 3, 1, 4 ]

5

true

Domain

KRIT1, ARM-repeats domain

ARM_KRIT1

7

IPR056486

56,486

HVO_2525, N-terminal

HVO_2525_N

Domain

263

false

This domain is found at the N-terminal of the predicted transcription regulator HVO_2525 ( ) from Haloferax volcanii and similar archaeal proteins. This domain is predicted to adopt an α-β structure. It is often found associated with .

[]

0

[ "PFAM" ]

[ "PF24279" ]

[ "HVO_2525_N" ]

[ 263 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Fervidobacterium pennivorans" ]

[ 262, 1 ]

2

[]

0

true

Domain

HVO_2525, N-terminal

HVO_2525_N

6

IPR056487

56,487

DpnD, N-terminal domain

DpnD_N

Domain

34

false

This entry represents a presumed domain found at the N-terminal of DpnD protein from Streptococcus pneumoniae and similar sequences from bacteria. These proteins are functionally uncharacterised. This domain is predicted to be all helical.

[]

0

[ "PFAM" ]

[ "PF23117" ]

[ "DpnD_N" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 34 ]

1

[]

0

true

Domain

DpnD, N-terminal domain

DpnD_N

4

IPR056488

56,488

HMPTM, N-terminal zinc ribbon domain

Zn_ribbon_HMPTM

Domain

2,443

false

This domain is found in 7,8-dihydro-6-hydroxymethylpterin dimethyltransferase (HMPTM) and related proteins from bacteria and archaea. HMPTM is involved in catalysing the methylation at C-7 and C-9 of 7,8-dihydro-6-hydroxymethylpterin, a common intermediate in both folate and MPT biosynthesis [ ]. The domain represented...

[]

0

[ "PFAM" ]

[ "PF23545" ]

[ "Zn_ribbon_HMPTM" ]

[ 2443 ]

1

[]

0

[ "7tol", "7tom" ]

2

[ "PUB00083593" ]

[ "25002541" ]

[ "Identification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 559, 1795, 10, 79 ]

4

[]

0

true

Domain

HMPTM, N-terminal zinc ribbon domain

Zn_ribbon_HMPTM

1

IPR056490

56,490

Rcc01698-like, C-terminal domain

Rcc01698_C

Domain

2,497

false

This domain is found in proteins mainly from alphaproteobacteria, such as Rcc01698 ( ) from Rhodobacter capsulatus and in some phage species [ ]. Alphaproteobacteria produce phage-like particles called gene transfer agents (GTAs) that mediate lateral gene exchange. Rcc01698 ( ) has been designated as megatron/g15 in [ ...

[]

0

[ "PFAM" ]

[ "PF23666" ]

[ "Rcc01698_C" ]

[ 2497 ]

1

[]

0

[ "6tba", "6teh", "8gtc" ]

3

[ "PUB00153971" ]

[ "32541663" ]

[ "Structure and mechanism of DNA delivery of a gene transfer agent." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "Viruses", "metagenomes" ]

[ 2398, 7, 67, 25 ]

4

[]

0

true

Domain

Rcc01698-like, C-terminal domain

Rcc01698_C

4

IPR056491

56,491

DUF6688, C-terminal domain

DUF6688_C

Domain

297

false

This entry represents a group of bacterial proteins that is functionally uncharacterised. Proteins in this family are typically between 360 and 412 amino acids in length. This entry corresponds to the C-terminal domain, which is predicted to be α-helical.

[]

0

[ "PFAM" ]

[ "PF23543" ]

[ "DUF6688_C" ]

[ 297 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 296, 1 ]

2

[]

0

true

Domain

DUF6688, C-terminal domain

DUF6688_C

5

IPR056492

56,492

Hsr-9, Tudor domain

SH3_Hsr9

Domain

196

false

This entry represents the tandem Tudor domains of Hsr-9 (also known as TP53-binding protein 1) from C. elegans and similar proteins mainly from nematodes. Hsr-9 may have a role in DNA double-strand break repair following gamma-irradiation [ ].

[]

0

[ "PFAM" ]

[ "PF24680" ]

[ "SH3_Hsr9" ]

[ 196 ]

1

[ "REACTOME" ]

[ "R-CEL-3232118" ]

[ "REACTOME:R-CEL-3232118" ]

1

[]

0

[ "PUB00102333" ]

[ "23667696" ]

[ "The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation." ]

[ 2013 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 196 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Hsr-9, Tudor domain

SH3_Hsr9

7

IPR056493

56,493

HVO_0513-like, N-terminal

HVO_0513_N

Domain

1,106

false

This domain is found at the N-terminal of the predicted transcription regulator HVO_0513 ( ) from Haloferax volcanii and similar archaeal proteins. This domain is predicted to adopt an α-β structure. It is often found associated with .

[]

0

[ "PFAM" ]

[ "PF24278" ]

[ "HVO_0513_N" ]

[ 1106 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteria" ]

[ 1106 ]

1

[]

0

true

Domain

HVO_0513-like, N-terminal

HVO_0513_N

7

IPR056494

56,494

DUF7108, C-terminal domain

DUF7108_C

Domain

324

false

This domain is found at the C-terminal end of the uncharacterised protein HVO_0731 from Haloferax volcanii ( ) and similar proteins from halobacteria. It is predicted to adopt an all-α structure. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF23420" ]

[ "DUF7108_C" ]

[ 324 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteria" ]

[ 324 ]

1

[]

0

true

Domain

DUF7108, C-terminal domain

DUF7108_C

7

IPR056496

56,496

Dynein axonemal assembly factor 11-like, CS domain

CS_DNAAF11_C

Domain

2,028

false

This domain is found at the C-terminal end of human Dynein axonemal assembly factor 11 (DNAAF11), TilB from Drosophila melanogaster and similar tilB family proteins mainly found in animals. DNAAF11 is involved in dynein arm assembly. It is important for expression and transporting outer dynein arm (ODA) proteins from t...

[]

0

[ "PFAM" ]

[ "PF23602" ]

[ "CS_DNAAF11_C" ]

[ 2028 ]

1

[]

0

[]

0

[ "PUB00158866", "PUB00158867", "PUB00158868", "PUB00158869" ]

[ "20215474", "23122589", "23527195", "33403504" ]

[ "Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility.", "Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia.", "LRRC6 mutation causes primary ciliary dyskinesia with dynein arm ...

[ 2010, 2012, 2013, 2021 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2028 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 4, 1, 6 ]

5

true

Domain

Dynein axonemal assembly factor 11-like, CS domain

CS_DNAAF11_C

4

IPR056497

56,497

Dynein axonemal assembly factor 5, HEAT-repeat domain

HEAT_DAAF5

Domain

2,083

false

This entry represents a domain found in the central region of Dynein axonemal assembly factor 5 (DAAF5) from animals, which consists of HEAT repeats. DAAF5 is a cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and out...

[]

0

[ "PFAM" ]

[ "PF24573" ]

[ "HEAT_DAAF5" ]

[ 2083 ]

1

[]

0

[]

0

[ "PUB00154951", "PUB00154952" ]

[ "23040496", "25232951" ]

[ "Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.", "HEATR2 plays a conserved role in assembly of the ciliary motile apparatus." ]

[ 2012, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2083 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 5, 2, 6 ]

5

true

Domain

Dynein axonemal assembly factor 5, HEAT-repeat domain

HEAT_DAAF5

3

IPR056498

56,498

DAAF9, N-terminal domain

DAAF9_N

Domain

1,194

false

This domain is found N-terminal in human DAAF9 and related proteins. It shares similarity with the aminopeptidase P domain of Spt16, a core component of the histone chaperone FACT. These domains likely share the same α/β fold with Ribonuclease H-like motif. Dynein axonemal assembly factor 9 DNAAF9 (Shulin) is a dynein ...

[]

0

[ "PFAM" ]

[ "PF23281" ]

[ "DAAF9_N" ]

[ 1194 ]

1

[]

0

[ "6zyw", "6zyx", "6zyy" ]

3

[ "PUB00109577" ]

[ "33632841" ]

[ "Shulin packages axonemal outer dynein arms for ciliary targeting." ]

[ 2021 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1194 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 9, 6 ]

4

true

Domain

DAAF9, N-terminal domain

DAAF9_N

6

IPR056499

56,499

HPS5-like, beta-propeller domain

Beta-prop_HPS5-like

Domain

2,647

false

This entry represents the β-propeller domain found in HPS5, a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2) [ ] and which has a role in the endo-lysosomal dynamics of skin fibroblasts [ ]. Its mutation or absence has been linked to eye-colour mutations in insects [ ] and Hermansky-Pudlak...

[]

0

[ "PFAM" ]

[ "PF23756" ]

[ "Beta-prop_HPS5" ]

[ 2647 ]

1

[]

0

[]

0

[ "PUB00043624", "PUB00085365", "PUB00141884", "PUB00155526", "PUB00155527" ]

[ "15030569", "9714595", "26431026", "28296950", "18544035" ]

[ "Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.", "Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery.", "TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.", "Cellular and molecular defects in a patient wi...

[ 2004, 1998, 2015, 2017, 2008 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2647 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 4, 10, 3 ]

6

true

Domain

HPS5-like, beta-propeller domain

Beta-prop_HPS5-like

8

IPR056501

56,501

HRPKS sdrA-like, NAD(P)-binding domain

NAD-bd_HRPKS_sdrA

Domain

6,688

false

This domain is found in Highly reducing polyketide synthase srdA from Neurospora crassa (HRPKS sdrA) and similar fungal proteins. HRPKS sdrA is part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol [ ]. This domain is predicted to ado...

[]

0

[ "PFAM" ]

[ "PF23114" ]

[ "NAD-bd_HRPKS_sdrA" ]

[ 6688 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

219

[]

0

[ "PUB00158870" ]

[ "30908040" ]

[ "Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial." ]

[ 2019 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6688 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Domain

HRPKS sdrA-like, NAD(P)-binding domain

NAD-bd_HRPKS_sdrA

2

IPR056502

56,502

KIAA0319-like, C-terminal domain

KIAA0319-like_C

Domain

2,545

false

This domain is found in human Dyslexia-associated protein KIAA0319 and related animal proteins. KIAA0319 is involved in neuronal migration during development of the cerebral neocortex. This protein probably function in a cell autonomous and a non-cell autonomous manner and plays a role in appropriate adhesion between m...

[]

0

[ "PFAM" ]

[ "PF23620" ]

[ "KIAA0319" ]

[ 2545 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8856825", "R-HSA-8856828", "R-MMU-8856825", "R-MMU-8856828", "R-RNO-8856825", "R-RNO-8856828" ]

[ "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-8856825", "REACTOME:R-MMU-8856828", "REACTOME:R-RNO-8856825", "REACTOME:R-RNO-8856828" ]

6

[]

0

[ "PUB00155696" ]

[ "19679544" ]

[ "The effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat." ]

[ 2010 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 2545 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 1, 17, 4, 10 ]

5

true

Domain

KIAA0319-like, C-terminal domain

KIAA0319-like_C

6

IPR056503

56,503

Dystrophin-1-like, spectrin repeat domain

Spectrin_Dys-1

Domain

178

false

This domain is found in Dystrophin-1 from Caenorhabditis elegans (Dys-1) and similar worm sequences. Dys-1 plays a role in cholinergic transmission and as a functional partner of dystrobrevin (Dyb-1), necessary for muscle maintenance. It is required for neuronal positioning [ , , ].

[]

0

[ "PFAM" ]

[ "PF23729" ]

[ "Spectrin_Dys-1" ]

[ 178 ]

1

[ "REACTOME" ]

[ "R-CEL-9913351" ]

[ "REACTOME:R-CEL-9913351" ]

1

[]

0

[ "PUB00074428", "PUB00074429", "PUB00158871" ]

[ "12234669", "21242290", "10996789" ]

[ "Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans.", "Neural integrity is maintained by dystrophin in C. elegans.", "Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans." ]

[ 2002, 2011, 2000 ]

3

[]

0

null

[ "Nematoda" ]

[ 178 ]

1

[ "Caenorhabditis elegans" ]

[ 7 ]

1

true

Domain

Dystrophin-1-like, spectrin repeat domain

Spectrin_Dys-1

9

IPR056504

56,504

HVO_0163, N-terminal HTH domain

HTH_HVO_0163_N

Domain

1,160

false

This HTH domain is found at the N-terminal of the ArsR family transcription regulator HVO_0163 ( ) from Haloferax volcanii and similar archaeal sequences.

[]

0

[ "PFAM" ]

[ "PF24266" ]

[ "HTH_HVO_0163_N" ]

[ 1160 ]

1

[]

0

[ "5duk" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria candidate phyla", "unclassified sequences" ]

[ 1119, 4, 37 ]

3

[]

0

true

Domain

HVO_0163, N-terminal HTH domain

HTH_HVO_0163_N

9

IPR056505

56,505

HVO_0234-like, beta-propeller

Beta-prop_HVO_0234

Domain

343

false

This family represents a group of proteins mainly from halobacteria, including HVO_0234 from Haloferax volcanii ( ). Members are predicted to adopt a β-propeller fold.

[]

0

[ "PFAM" ]

[ "PF23366" ]

[ "Beta-prop_HVO_0234" ]

[ 343 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales" ]

[ 6, 337 ]

2

[]

0

true

Domain

HVO_0234-like, beta-propeller

Beta-prop_HVO_0234

6

IPR056506

56,506

iHD-CE

Domain

343

false

This entry represents an inactive HD-CE domain (iHD-CE) which acts as a sensor in the antiviral immunity systems and it is predominantly located within HSP90 systems. Specifically, it is associated with wHTH repeats located at the C-terminal ( ) [ ].

[]

0

[ "PFAM" ]

[ "PF24401" ]

[ "iHD-CE" ]

[ 343 ]

1

[]

0

[]

0

[ "PUB00155486" ]

[ "37889040" ]

[ "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 343 ]

1

[]

0

true

Domain

iHD-CE

4

IPR056507

56,507

wHTH-Hsp90, Na associated

wHTH-HSP90_Na-assoc

Domain

432

false

This is a wHTH domain commonly observed in tandem repeats with 5 or more modules and located at the C-terminal of HSP90 proteins engaged in antiviral immunity. These proteins often additionally feature an inactive HD-CE domain ( ) at the N-terminal. Structural modelling suggests that the wHTH repeats form a ring-shaped...

[]

0

[ "PFAM" ]

[ "PF24410" ]

[ "wHTH-HSP90_Na-assoc" ]

[ 432 ]

1

[]

0

[]

0

[ "PUB00155486" ]

[ "37889040" ]

[ "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 432 ]

1

[]

0

true

Domain

wHTH-Hsp90, Na associated

wHTH-HSP90_Na-assoc

6

IPR056508

56,508

Hydroxyproline O-arabinosyltransferase-like domain

HPAT-like

Domain

3,463

false

The Hydroxyproline O-arabinosyltransferase family is comprised of glycosyltransferases involved in the post-translational modification of plant proteins. Members of this family catalyse the transfer of L-arabinose to the hydroxyl group of hydroxyproline (Hyp) residues in target proteins, such as extensins and small sig...

[]

0

[ "PFAM" ]

[ "PF23452" ]

[ "HPAT" ]

[ 3463 ]

1

[ "EC" ]

[ "2.4.2.58" ]

[ "EC:2.4.2.58" ]

1

[]

0

[ "PUB00097320", "PUB00097321" ]

[ "26577059", "24914209" ]

[ "Hydroxyproline O-arabinosyltransferase mutants oppositely alter tip growth in Arabidopsis thaliana and Physcomitrella patens.", "Identification of Novel Peptidyl Serine α-Galactosyltransferase Gene Family in Plants." ]

[ 2016, 2014 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati", "viral metagenome" ]

[ 3460, 2, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 16, 15, 35 ]

3

true

Domain

Hydroxyproline O-arabinosyltransferase-like domain

HPAT-like

2

IPR056509

56,509

Imm33-like domain

Imm33-like

Domain

1,004

false

This entry represents a family of bacterial proteins that are structurally related to the Imm33 family of putative immunity proteins.

[]

0

[ "PFAM" ]

[ "PF24719" ]

[ "Imm33-like" ]

[ 1004 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1001, 3 ]

2

[]

0

true

Domain

Imm33-like domain

Imm33-like

6

IPR056510

56,510

Immunity protein WapI-like

WapI

Family

1,024

false

The WapI family comprises immunity proteins that are part of a toxin-immunity protein module functioning as a cellular contact-dependent growth inhibition (CDI) system. These proteins neutralize the tRNase activity of their cognate toxin WapA upon expression in E.coli [ , ]. Notably, they do not inhibit WapA from other...

[]

0

[ "PFAM" ]

[ "PF24716" ]

[ "WapI" ]

[ 1024 ]

1

[]

0

[]

0

[ "PUB00088067", "PUB00101092" ]

[ "23572593", "34280190" ]

[ "Rhs proteins from diverse bacteria mediate intercellular competition.", "Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms." ]

[ 2013, 2021 ]

2

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctgmM3", "ecological metagenomes" ]

[ 1017, 1, 6 ]

3

[]

0

true

Family

Immunity protein WapI-like

WapI

2

IPR056511

56,511

Increased DNA methylation 1, C-terminal

IDM1_C

Domain

7,195

false

This domain is found at the C-terminal end of Increased DNA methylation 1 (IDM1) from Arabidopsis thaliana and similar plant proteins. IDM1 is a histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyses H3K18 and H3K23 acetylation [ , ]. It is als...

[]

0

[ "PFAM" ]

[ "PF23209" ]

[ "IDM1_C" ]

[ 7195 ]

1

[]

0

[]

0

[ "PUB00074469", "PUB00158872", "PUB00158873" ]

[ "22700931", "31486938", "33615694" ]

[ "A histone acetyltransferase regulates active DNA demethylation in Arabidopsis.", "Characterization and fine mapping of Arabidopsis RLL3, a locus required for DNA demethylation pathway.", "A novel protein complex that regulates active DNA demethylation in Arabidopsis." ]

[ 2012, 2020, 2021 ]

3

[]

0

null

[ "Candidatus Bodocaedibacter vickermanii", "Eukaryota" ]

[ 1, 7194 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 77, 31, 132 ]

3

true

Domain

Increased DNA methylation 1, C-terminal

IDM1_C

4

IPR056512

56,512

Putative E3 ubiquitin-protein ligase LIN, N-terminal domain

LIN_N

Domain

2,392

false

This region is found towards the N-terminal end in a group of plant proteins, including the putative E3 ubiquitin-protein ligase LIN from Medicago truncatula. This domain is predicted to consist of ARM-like repeats. E3 ubiquitin-protein ligase LIN is involved in the rhizobial infection process [ ]. This protein plays a...

[]

0

[ "PFAM" ]

[ "PF23568" ]

[ "ARM_LIN" ]

[ 2392 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00156035", "PUB00156036" ]

[ "15516512", "19776163" ]

[ "LIN, a Medicago truncatula gene required for nodule differentiation and persistence of rhizobial infections.", "LIN, a novel type of U-box/WD40 protein, controls early infection by rhizobia in legumes." ]

[ 2004, 2009 ]

2

[]

0

null

[ "Bacteria", "Streptophyta" ]

[ 2, 2390 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 7, 7 ]

3

true

Domain

Putative E3 ubiquitin-protein ligase LIN, N-terminal domain

LIN_N

5

IPR056513

56,513

INO80 complex subunit F

INO80F

Domain

2,563

false

This entry represents the helical region from INO80 subunit F (also known as TCF3 fusion partner, TFTP or amida) from vertebrates and its orthologues from fungi, including S. pombe Hap2 ( ) and Ino80 complex HMG box subunit Nht1 ( ). It plays an important role in p53-independent cellular apoptosis [ ] and it also plays...

[]

0

[ "PFAM" ]

[ "PF24245" ]

[ "INO80F" ]

[ 2563 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5689603", "R-BTA-5696394", "R-HSA-5689603", "R-HSA-5696394", "R-MMU-5689603", "R-MMU-5696394", "R-RNO-5689603", "R-RNO-5696394" ]

[ "REACTOME:R-BTA-5689603", "REACTOME:R-BTA-5696394", "REACTOME:R-HSA-5689603", "REACTOME:R-HSA-5696394", "REACTOME:R-MMU-5689603", "REACTOME:R-MMU-5696394", "REACTOME:R-RNO-5689603", "REACTOME:R-RNO-5696394" ]

8

[]

0

[ "PUB00062156", "PUB00079070", "PUB00079071", "PUB00079072", "PUB00155681" ]

[ "21303910", "17041757", "11606057", "12841360", "20237820" ]

[ "Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.", "Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced.", "Amida ...

[ 2011, 2006, 2001, 2003, 2010 ]

5

[]

0

null

[ "Eukaryota", "Salibacterium salarium" ]

[ 2561, 2 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 3, 3, 1, 5, 2 ]

7

true

Domain

INO80 complex subunit F

INO80F

4

IPR056514

56,514

Putative E3 ubiquitin-protein ligase LIN, ARM repeats domain

ARM_LIN_2nd

Domain

2,192

false

This region of armadillo-like repeats is found in a group of plant proteins, including the putative E3 ubiquitin-protein ligase LIN from Medicago truncatula. This entry is often found C-terminal to and N-terminal to . E3 ubiquitin-protein ligase LIN is involved in the rhizobial infection process [ ]. This protein plays...

[]

0

[ "PFAM" ]

[ "PF23654" ]

[ "ARM_LIN_2nd" ]

[ 2192 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00156035", "PUB00156036" ]

[ "15516512", "19776163" ]

[ "LIN, a Medicago truncatula gene required for nodule differentiation and persistence of rhizobial infections.", "LIN, a novel type of U-box/WD40 protein, controls early infection by rhizobia in legumes." ]

[ 2004, 2009 ]

2

[]

0

null

[ "Embryophyta" ]

[ 2192 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 10, 23 ]

3

true

Domain

Putative E3 ubiquitin-protein ligase LIN, ARM repeats domain

ARM_LIN_2nd

2

IPR056516

56,516

Integrator complex subunit 7, N-terminal

INTS7_N

Domain

2,860

false

This entry represents the superhelical α-solenoid found at the N-terminal of INTS7. Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the l...

[]

0

[ "PFAM" ]

[ "PF24436" ]

[ "INTS7_N" ]

[ 2860 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807505", "R-DDI-6807505", "R-DME-6807505", "R-DRE-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-BTA-6807505", "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

6

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

8

[ "PUB00035147", "PUB00045283", "PUB00053803", "PUB00077569", "PUB00077570", "PUB00152015" ]

[ "12529635", "16239144", "12006978", "15716491", "19326441", "33243860" ]

[ "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.", "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.", "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate dev...

[ 2003, 2005, 2002, 2005, 2009, 2020 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2860 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 3, 1, 2, 2, 2, 4, 7 ]

9

true

Domain

Integrator complex subunit 7, N-terminal

INTS7_N

8

IPR056517

56,517

Integrator complex subunit 7, helical bundle

INTS7_HB

Domain

2,054

false

This entry represents the helical bundle (HB) of INTS7, localised between the superhelical α-solenoid ( ) and the C-terminal β-sandwich ( ) [ ]. Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The i...

[]

0

[ "PFAM" ]

[ "PF24437" ]

[ "INTS7_HB" ]

[ 2054 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807505", "R-DDI-6807505", "R-DME-6807505", "R-DRE-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-BTA-6807505", "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

6

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

8

[ "PUB00035147", "PUB00045283", "PUB00053803", "PUB00077569", "PUB00077570", "PUB00152015" ]

[ "12529635", "16239144", "12006978", "15716491", "19326441", "33243860" ]

[ "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.", "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.", "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate dev...

[ 2003, 2005, 2002, 2005, 2009, 2020 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2054 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 3, 1, 2, 2, 4 ]

6

true

Domain

Integrator complex subunit 7, helical bundle

INTS7_HB

5