Datasets:
LiteFold
/
InterPro

Dataset card Data Studio Files
xet
 Community
interpro_id
string
interpro_numeric_id
int64
name
string
short_name
string
entry_type
string
protein_count
int64
is_llm
bool
is_llm_reviewed
bool
abstract
string
go_ids
list
go_terms
list
go_categories
list
go_count
int64
member_databases
list
member_accessions
list
member_names
list
member_protein_counts
list
member_count
int64
external_databases
list
external_accessions
list
external_xrefs
list
external_xref_count
int64
pdb_ids
list
structure_count
int64
publication_ids
list
pubmed_ids
list
publication_titles
list
publication_years
list
publication_count
int64
parent_ids
list
child_ids
list
parent_count
int64
child_count
int64
tree_depth
float64
taxonomy_names
list
taxonomy_protein_counts
list
taxonomy_count
int64
key_species_names
list
key_species_protein_counts
list
key_species_count
int64
in_entry_list
bool
entry_list_type
string
entry_list_name
string
names_dat_name
string
short_names_dat_name
string
split_bucket
int64
IPR056749
56,749
ATP-citrate synthase, ATP-grasp domain
Citrate_synth_N
Domain
6,817
false
false
This entry represents the N-terminal ATP-grasp domain of ATP-citrate synthases. The ATP-citrate synthase family is responsible for the synthesis of cytosolic acetyl-CoA, a crucial substrate for de novo lipid synthesis, including cholesterol and fatty acids. In animals, these enzymes typically have a homomeric structure...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24948" ]
[ "Citrate_synth_N" ]
[ 6817 ]
1
[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.3.3.8", "PWY-5172", "R-BTA-6798695", "R-BTA-75105", "R-CEL-6798695", "R-CEL-75105", "R-HSA-163765", "R-HSA-6798695", "R-HSA-75105", "R-MMU-6798695", "R-MMU-75105", "R-RNO-6798695", "R-RNO-75105" ]
[ "EC:2.3.3.8", "METACYC:PWY-5172", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-75105", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-75105", "REACTOME:R-HSA-163765", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-75105", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-75105", "REACTOME:R-RNO-6798695", "REACTO...
13
[ "3mwd", "3mwe", "3pff", "5tde", "5tdf", "5tdm", "5tdz", "5te1", "5teq", "5tes", "5tet", "6hxh", "6hxi", "6o0h", "6poe", "6pof", "6qfb", "6ui9", "6uia", "6uuw", "6uuz", "6uv5", "6znw", "7liw", "7lj9", "7lla", "7rig", "7rkz", "7rmp", "8g1e", "8g1f", "8g5c"...
33
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Tupanvirus", "ecological metagenomes" ]
[ 15, 146, 6623, 4, 29 ]
5
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...
[ 10, 2, 7, 4, 3, 5, 1, 5, 10, 1, 7 ]
11
true
Domain
ATP-citrate synthase, ATP-grasp domain
ATP-citrate synthase, ATP-grasp domain
Citrate_synth_N
1
IPR056750
56,750
ESF1, RRM domain
RRM_ESF1
Domain
4,319
false
false
This domain is found in the yeast Pre-rRNA-processing protein ESF1 and related eukaryotic proteins. ESF1 is involved in the 18S rRNA synthesis and required for the early cleavages at sites A0, A1 and A2 [ ]. This domain has a detectable similarity to known RNA binding domains.
[]
[]
[]
0
[ "PFAM" ]
[ "PF25121" ]
[ "RRM_ESF1" ]
[ 4319 ]
1
[]
[]
[]
0
[]
0
[ "PUB00090055" ]
[ "15056729" ]
[ "ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae." ]
[ 2004 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4319 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 5, 1, 1, 2, 4, 3, 1, 3, 3, 1, 1, 3 ]
12
true
Domain
ESF1, RRM domain
ESF1, RRM domain
RRM_ESF1
2
IPR056751
56,751
ERT1/acuK family, PAS domain
PAS_13
Domain
3,828
false
false
This entry represents a C-terminal PAS domain found in ERT1/acuK proteins. The ERT1/acuK family consists of transcription factors that play a crucial role in regulating nonfermentable carbon utilization. These proteins act as activators of gluconeogenetic genes, facilitating the conversion of non-carbohydrate substrate...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24990" ]
[ "PAS_13" ]
[ 3828 ]
1
[]
[]
[]
0
[]
0
[ "PUB00096371", "PUB00160039", "PUB00160040", "PUB00160041", "PUB00160042" ]
[ "19686338", "22500966", "25123508", "18202368", "17339216" ]
[ "Transcriptional regulation of nonfermentable carbon utilization in budding yeast.", "Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans.", "The switch from fermentation to respiration in Saccharomyces cerevisiae is regulated by the Ert1 transcriptional ac...
[ 2010, 2012, 2014, 2008, 2007 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3828 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]
[ 2, 3 ]
2
true
Domain
ERT1/acuK family, PAS domain
ERT1/acuK family, PAS domain
PAS_13
5
IPR056752
56,752
Elongation factor-like GTPase 1 domain
EFL1
Domain
3,996
false
false
This domain is found in human Elongation factor-like GTPase 1 (EFL1) and similar eukaryotic proteins, including yeast homologue known as Ribosome assembly protein 1. EFL1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25118" ]
[ "EFL1" ]
[ 3996 ]
1
[ "EC" ]
[ "3.6.5.-" ]
[ "EC:3.6.5.-" ]
1
[ "5anb", "5anc" ]
2
[ "PUB00076340", "PUB00100665", "PUB00152086", "PUB00159893" ]
[ "21536732", "26912367", "33007253", "26479198" ]
[ "Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.", "Molecular architecture of the human U4/U6.U5 tri-snRNP.", "Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.", "Mechanism of eIF6 release from the nasce...
[ 2011, 2016, 2020, 2015 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3996 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 6, 1, 2, 2, 6, 1, 1, 4, 3, 1, 1, 2 ]
12
true
Domain
Elongation factor-like GTPase 1 domain
Elongation factor-like GTPase 1 domain
EFL1
6
IPR056753
56,753
DrmE-like, N-terminal domain
DrmE_N
Domain
9
false
false
This domain is found in DISARM (Defense Island System Associated with Restriction-Modification) protein DrmE and related proteins from Halobacteria [ ]. It is predicted to adopt a globular structure composed of a central parallel β-sheet and α-helices packed on both sides of it.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24955" ]
[ "DrmE_N" ]
[ 9 ]
1
[]
[]
[]
0
[]
0
[ "PUB00105719" ]
[ "29085076" ]
[ "DISARM is a widespread bacterial defence system with broad anti-phage activities." ]
[ 2018 ]
1
[]
[]
0
0
null
[ "Halobacteriales" ]
[ 9 ]
1
[]
[]
0
true
Domain
DrmE-like, N-terminal domain
DrmE-like, N-terminal domain
DrmE_N
8
IPR056754
56,754
DSCAM/DSCAML, C-terminal domain
DSCAM/DSCAML_C
Domain
8,079
false
false
This entry represents a Fn3-like domain found at the C-terminal of DSCAM and DSCAML. DSCAM and DSCAML are cell adhesion molecules that play a role in neuronal self-avoidance. They promote repulsion between specific neuronal processes of either the same cell or the same subtype of cells [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25059" ]
[ "FN3_DSCAM-DSCAML_C" ]
[ 8079 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DME-376172", "R-HSA-376172", "R-MMU-376172", "R-RNO-376172" ]
[ "REACTOME:R-DME-376172", "REACTOME:R-HSA-376172", "REACTOME:R-MMU-376172", "REACTOME:R-RNO-376172" ]
4
[]
0
[ "PUB00049782", "PUB00055130", "PUB00077466", "PUB00119432" ]
[ "18261743", "21300289", "19196994", "10925149" ]
[ "Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.", "Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.", "DSCAM functions as a netrin receptor in commissural axon pathfinding.", "Down syndrome cell adhesion molecule DSC...
[ 2008, 2011, 2009, 2000 ]
4
[]
[]
0
0
null
[ "Bilateria" ]
[ 8079 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 19, 83, 6, 6, 8 ]
5
true
Domain
DSCAM/DSCAML, C-terminal domain
DSCAM/DSCAML, C-terminal domain
DSCAM/DSCAML_C
9
IPR056755
56,755
dsRNA binding domain
DSRM_2
Domain
2,580
false
false
This entry represents a a set of divergent dsRNA binding domains. They are found in functionally diverse proteins such as Dicer-like protein 1, ATP-dependent RNA helicase DHX30 and Small RNA 2'-O-methyltransferase HEN1 [ , , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24995" ]
[ "DSRM_2" ]
[ 2580 ]
1
[ "EC", "EC", "METACYC" ]
[ "3.1.26.-", "3.6.4.-", "PWY-7250" ]
[ "EC:3.1.26.-", "EC:3.6.4.-", "METACYC:PWY-7250" ]
3
[ "2db2", "3htx" ]
2
[ "PUB00060815", "PUB00159959", "PUB00159960" ]
[ "11874905", "14993290", "29100085" ]
[ "HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower.", "Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa.", "De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Diso...
[ 2002, 2004, 2017 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2580 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]
[ 11, 2, 2, 5, 1, 9 ]
6
true
Domain
dsRNA binding domain
dsRNA binding domain
DSRM_2
2
IPR056756
56,756
DUF2110, central domain
DUF2110_central
Domain
440
false
false
This domain, found in various hypothetical archaeal proteins, has no known function. This domain is the middle of three domains found in the DUF2110 family proteins. It has an OB-like fold.
[]
[]
[]
0
[ "PFAM" ]
[ "PF09883" ]
[ "DUF2110" ]
[ 440 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "ecological metagenomes" ]
[ 434, 6 ]
2
[]
[]
0
true
Domain
DUF2110, central domain
DUF2110, central domain
DUF2110_central
8
IPR056757
56,757
DUF2110, C-terminal domain
DUF2110_C
Domain
443
false
false
This domain, found in various hypothetical archaeal proteins, has no known function. It is found at the C-terminal of DUF2110 family proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24873" ]
[ "DUF2110_C" ]
[ 443 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "ecological metagenomes" ]
[ 434, 9 ]
2
[]
[]
0
true
Domain
DUF2110, C-terminal domain
DUF2110, C-terminal domain
DUF2110_C
1
IPR056758
56,758
DUF2110, N-terminal domain
DUF2110_N
Domain
436
false
false
This domain, found in various hypothetical archaeal proteins, has no known function. It is found at the N-terminal of the DUF2110 family proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24872" ]
[ "DUF2110_N" ]
[ 436 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "ecological metagenomes" ]
[ 434, 2 ]
2
[]
[]
0
true
Domain
DUF2110, N-terminal domain
DUF2110, N-terminal domain
DUF2110_N
3
IPR056759
56,759
Dynein axonemal heavy chain 2/5/8, coiled-coil domain
DYH2-5-8_CC
Domain
4,100
false
false
This entry represents a coiled-coil region found in Dynein axonemal heavy chains 2/5/8 and related proteins, including Dynein gamma and Dynein-1-beta heavy chain. These proteins are involved in sperm and flagella motility. DYH2 is part of the axonemal inner dynein arm complex and plays a central role in ciliary beat [ ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25007" ]
[ "DYH2-5-8_CC" ]
[ 4100 ]
1
[]
[]
[]
0
[ "7kzm", "7kzn", "7kzo", "8glv", "8j07", "9e5c", "9fqr" ]
7
[ "PUB00159892" ]
[ "30811583" ]
[ "DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella." ]
[ 2019 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4100 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 12, 8, 7, 7, 7 ]
5
true
Domain
Dynein axonemal heavy chain 2/5/8, coiled-coil domain
Dynein axonemal heavy chain 2/5/8, coiled-coil domain
DYH2-5-8_CC
2
IPR056760
56,760
E3 ubiquitin-protein ligase XB3-like, RING finger
RING_XB3-like
Domain
2,878
false
false
This entry represents the RING finger domain found at the C-terminal end of E3 ubiquitin-protein ligase XB3 from rice and its plant homologues, including XBAT31/32/33 from Arabidopsis thaliana. XB3 is an E3 ubiquitin-protein ligase required for full accumulation of the LRR receptor kinase XA21 and XA21-mediated disease...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24921" ]
[ "RING_XB3-XBAT31" ]
[ 2878 ]
1
[ "EC", "METACYC" ]
[ "2.3.2.27", "PWY-7511" ]
[ "EC:2.3.2.27", "METACYC:PWY-7511" ]
2
[]
0
[ "PUB00159929", "PUB00159930" ]
[ "17172358", "38870009" ]
[ "Rice XA21 binding protein 3 is a ubiquitin ligase required for full Xa21-mediated disease resistance.", "XBAT31 regulates reproductive thermotolerance through controlling the accumulation of HSFB2a/B2b under heat stress conditions." ]
[ 2006, 2024 ]
2
[ "IPR001841" ]
[]
1
0
1
[ "Eukaryota" ]
[ 2878 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 15, 14, 51 ]
3
true
Domain
E3 ubiquitin-protein ligase XB3-like, RING finger
E3 ubiquitin-protein ligase XB3-like, RING finger
RING_XB3-like
6
IPR056761
56,761
E3 UFM1-protein ligase-like, C-terminal domain
Ufl1-like_C
Domain
2,540
false
false
This domain is found C-terminal in human E3 UFM1-protein ligase 1 (Ufl1) and similar eukaryotic sequences. This domain is predicted to adopt a globular structure consisting of an array of α-helices. The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylatio...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25041" ]
[ "UFL1_C" ]
[ 2540 ]
1
[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887", "R-BTA-983168", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-DRE-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168" ]
[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", ...
19
[ "8ohd", "8oj0", "8oj5", "8oj8", "8qfc", "8qfd", "9gy4" ]
7
[ "PUB00054168", "PUB00086011", "PUB00088961", "PUB00095670", "PUB00095671", "PUB00159944" ]
[ "20018847", "20228063", "25219498", "32160526", "20164180", "38383789" ]
[ "A novel type of E3 ligase for the Ufm1 conjugation system.", "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.", "Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development."...
[ 2010, 2010, 2014, 2020, 2010, 2024 ]
6
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2540 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 1, 2, 1, 1, 1, 3, 5 ]
9
true
Domain
E3 UFM1-protein ligase-like, C-terminal domain
E3 UFM1-protein ligase-like, C-terminal domain
Ufl1-like_C
9
IPR056762
56,762
Tumor necrosis factor receptor superfamily member EDAR, death domain
Death_EDAR
Domain
1,033
false
false
This entry represents a death domain found in the human Tumor necrosis factor receptor superfamily member EDAR and similar animal proteins. EDAR is a receptor for ectodysplasin A (EDA) isoforms, specifically binding to isoform A1 in humans but not to isoform A2 [ ]. This protein family is involved in mediating the acti...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24979" ]
[ "Death_EDAR" ]
[ 1033 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-5669034", "R-MMU-5669034" ]
[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034" ]
2
[]
0
[ "PUB00160054" ]
[ "19619491" ]
[ "Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction." ]
[ 2009 ]
1
[]
[]
0
0
null
[ "Chordata" ]
[ 1033 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 2, 2, 1 ]
4
true
Domain
Tumor necrosis factor receptor superfamily member EDAR, death domain
Tumor necrosis factor receptor superfamily member EDAR, death domain
Death_EDAR
2
IPR056764
56,764
EIF2B subunit epsilon/gamma, LbH domain
LbH_EIF2B3/5
Domain
8,671
false
false
This entry represents the central Left-handed parallel beta-Helix (LbH) domain of Translation initiation factor eIF-2B subunit epsilon/gamma (EIF2B3/5) and similar proteins from cellular organisms. These proteins function as as components of the translation initiation factor 2B (eIF2B) complex, which catalyses the exch...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25084" ]
[ "LbH_EIF2B" ]
[ 8671 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-72731", "R-DDI-72731", "R-HSA-72731", "R-MMU-72731", "R-RNO-72731", "R-SCE-72731", "R-SPO-72731" ]
[ "REACTOME:R-CEL-72731", "REACTOME:R-DDI-72731", "REACTOME:R-HSA-72731", "REACTOME:R-MMU-72731", "REACTOME:R-RNO-72731", "REACTOME:R-SCE-72731", "REACTOME:R-SPO-72731" ]
7
[ "5b04", "6caj", "6ezo", "6i3m", "6i7t", "6jly", "6jlz", "6k71", "6k72", "6o81", "6o85", "6o9z", "6qg0", "6qg1", "6qg2", "6qg3", "6qg5", "6qg6", "7d43", "7d44", "7d45", "7d46", "7f64", "7f66", "7f67", "7kmf", "7l70", "7l7g", "7rlo", "7trj", "7vlk", "8tqo"...
33
[ "PUB00153166", "PUB00153167", "PUB00153168" ]
[ "25858979", "27023709", "31048492" ]
[ "Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.", "Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.", "Structural basis for eIF2B inhibition in integrated stress response." ]
[ 2015, 2016, 2019 ]
3
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 118, 756, 7759, 38 ]
4
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 14, 2, 2, 3, 7, 4, 2, 7, 7, 1, 2, 18 ]
12
true
Domain
EIF2B subunit epsilon/gamma, LbH domain
EIF2B subunit epsilon/gamma, LbH domain
LbH_EIF2B3/5
5
IPR056767
56,767
KIN17, C2H2-type zinc finger domain
C2H2-Znf_KIN17
Domain
4,585
false
false
This entry represents the C2H2-type zinc finger domain is found at the N terminus of KIN17 , which is involved in RNA binding, and related eukaryotic proteins [ ]. KIN17 is an essential, highly conserved nuclear protein that functions in DNA replication, DNA repair and cell cycle control [ , , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25095" ]
[ "C2H2-zf_KIN17" ]
[ 4585 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8876725", "R-MMU-8876725" ]
[ "REACTOME:R-HSA-8876725", "REACTOME:R-MMU-8876725" ]
2
[ "7abh", "7abi", "8i0p" ]
3
[ "PUB00047193", "PUB00086756", "PUB00086757" ]
[ "17045609", "15831485", "28454391" ]
[ "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.", "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins.", "Upregulation of KIN17 is associat...
[ 2006, 2005, 2017 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4585 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 8, 1, 2, 3, 1, 1, 1, 2, 3, 1, 1, 4 ]
12
true
Domain
KIN17, C2H2-type zinc finger domain
KIN17, C2H2-type zinc finger domain
C2H2-Znf_KIN17
2
IPR056768
56,768
Piezo, transmembrane helical unit
THU_Piezo
Domain
6,023
false
false
This entry represents one of the THUs of Piezo proteins from animals and plants, including Piezo-type mechanosensitive ion channel component 1 from mouse (Piezo1). Piezo is a family of proteins that form mechanosensitive non-specific cation channels whose conductance is higher for Li+, intermediate for Na+ and lowest f...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23188" ]
[ "THU_Piezo1" ]
[ 6023 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-9856530", "R-HSA-9856532", "R-HSA-9860927" ]
[ "REACTOME:R-HSA-9856530", "REACTOME:R-HSA-9856532", "REACTOME:R-HSA-9860927" ]
3
[ "5z10", "6b3r", "6bpz", "6kg7", "6lqi", "7wlt", "7wlu", "8imz", "8ixn", "8ixo", "8yez", "8yfc", "8yfg", "8zu3", "8zu8", "9vmx" ]
16
[ "PUB00063635", "PUB00155396", "PUB00155397", "PUB00155398", "PUB00155399", "PUB00155860", "PUB00155861", "PUB00155862" ]
[ "20813920", "25242456", "25955826", "31435011", "35388220", "29469092", "29261642", "32142647" ]
[ "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.", "The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.", "Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels.", "Structure and mechanogating of the ...
[ 2010, 2014, 2015, 2019, 2022, 2018, 2018, 2020 ]
8
[]
[]
0
0
null
[ "Eukaryota" ]
[ 6023 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 21, 12, 5, 12, 1, 11, 12 ]
9
true
Domain
Piezo, transmembrane helical unit
Piezo, transmembrane helical unit
THU_Piezo
8
IPR056769
56,769
Piezo, TM1-24
Piezo_TM1-24
Domain
5,253
false
false
This entry represents the N-terminal TM segment (TM1-24) which are peripheral part of the blade and exhibit a greater degree of flexibility of these helices relative to TM25-TM36, as apparently, they do not have intracellular supporting structures [ ]. Members of this entry are found in animals. Piezo is a family of pr...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24871" ]
[ "Piezo_TM1-24" ]
[ 5253 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-9856530", "R-HSA-9856532", "R-HSA-9860927" ]
[ "REACTOME:R-HSA-9856530", "REACTOME:R-HSA-9856532", "REACTOME:R-HSA-9860927" ]
3
[ "5z10", "6b3r", "6kg7", "6lqi", "7wlt", "7wlu", "8imz", "8ixn", "8ixo", "8yez", "8yfc", "8yfg", "8zu3", "8zu8", "9vmx" ]
15
[ "PUB00063635", "PUB00155396", "PUB00155397", "PUB00155398", "PUB00155399", "PUB00155860" ]
[ "20813920", "25242456", "25955826", "31435011", "35388220", "29469092" ]
[ "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.", "The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.", "Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels.", "Structure and mechanogating of the ...
[ 2010, 2014, 2015, 2019, 2022, 2018 ]
6
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5253 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 19, 13, 7, 14, 10 ]
6
true
Domain
Piezo, TM1-24
Piezo, TM1-24
Piezo_TM1-24
4
IPR056770
56,770
Piezo, THU9 and anchor domain
Piezo_THU9_anchor
Domain
6,561
false
false
This entry represents a TM segment comprising TM33-36 (THU9) and the anchor domain of Piezo proteins, found towards the C-terminal before the cap domain [ ]. Members of this entry are found in animals and plants. Piezo is a family of proteins that form mechanosensitive non-specific cation channels whose conductance is ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24874" ]
[ "Piezo_THU9_anchor" ]
[ 6561 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-9856530", "R-HSA-9856532", "R-HSA-9860927" ]
[ "REACTOME:R-HSA-9856530", "REACTOME:R-HSA-9856532", "REACTOME:R-HSA-9860927" ]
3
[ "3jac", "5z10", "6b3r", "6bpz", "6kg7", "6lqi", "7wlt", "7wlu", "8imz", "8ixn", "8ixo", "8yez", "8yfc", "8yfg", "8zu3", "8zu8", "9vmx" ]
17
[ "PUB00063635", "PUB00155396", "PUB00155397", "PUB00155398", "PUB00155399", "PUB00155860" ]
[ "20813920", "25242456", "25955826", "31435011", "35388220", "29469092" ]
[ "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.", "The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.", "Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels.", "Structure and mechanogating of the ...
[ 2010, 2014, 2015, 2019, 2022, 2018 ]
6
[]
[]
0
0
null
[ "Eukaryota" ]
[ 6561 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 21, 12, 10, 15, 2, 11, 15 ]
9
true
Domain
Piezo, THU9 and anchor domain
Piezo, THU9 and anchor domain
Piezo_THU9_anchor
1
IPR056771
56,771
FHOD1/3-like, FH3 domain
FH3_FHOD1-3-like
Domain
4,878
false
false
This is the FH3 domain of FH1/FH2 domain-containing proteins 1 and 3 from human [ , ] and related sequences, including ELMOA, Formin-G and Formin-C from Dictyostelium discoideum. FHOD1 is required for the assembly of F-actin structures, such as stress fibres and depends on the Rho-ROCK cascade for its activity. It cont...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24959" ]
[ "FH3_FHOD1-3" ]
[ 4878 ]
1
[]
[]
[]
0
[ "3dad", "6xf1", "6xf2" ]
3
[ "PUB00051314", "PUB00066285", "PUB00159895" ]
[ "18786395", "15878344", "33472039" ]
[ "The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.", "FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation.", "Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins." ]
[ 2008, 2005, 2021 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4878 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 8, 37, 11, 5, 3, 8 ]
6
true
Domain
FHOD1/3-like, FH3 domain
FHOD1/3-like, FH3 domain
FH3_FHOD1-3-like
7
IPR056772
56,772
Origin recognition complex subunit 2, RecA-like domain
RecA-like_ORC2
Domain
4,605
false
false
This entry represents the RecA-like domain of Origin recognition complex subunit 2 (ORC2) with no predicted ATPase activity [ ]. The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded by ORC1-6 [ ]. ORC is a central component for eukaryotic DNA replication, and binds chromatin a...
[]
[]
[]
0
[ "PFAM" ]
[ "PF04084" ]
[ "RecA-like_ORC2" ]
[ 4605 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-CEL-68616", "R-CEL-68949", "R-CEL-68962", "R-DDI-68616", "R-DDI-68689", "R-DDI-68962", "R-DME-176187", "R-DME-68616", "R-DME-68689", "R-DME-68949", "R-DME-68962", "R-HSA-113507", "R-HSA-176187", "R-HSA-68616", "R-HSA-68689", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-MMU-...
[ "REACTOME:R-CEL-68616", "REACTOME:R-CEL-68949", "REACTOME:R-CEL-68962", "REACTOME:R-DDI-68616", "REACTOME:R-DDI-68689", "REACTOME:R-DDI-68962", "REACTOME:R-DME-176187", "REACTOME:R-DME-68616", "REACTOME:R-DME-68689", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-HSA-113507", "R...
37
[ "4xgc", "5uj8", "5ujm", "5v8f", "5zr1", "6rqc", "6wgc", "6wgg", "6wgi", "7cte", "7ctf", "7ctg", "7jgr", "7jgs", "7jk2", "7jk3", "7jk4", "7jk5", "7jk6", "7jpo", "7jpp", "7jpq", "7jpr", "7jps", "7mca", "7tjf", "7tjh", "7tji", "7tjj", "7tjk", "8rwv", "8s0c"...
43
[ "PUB00011408", "PUB00052559", "PUB00052560", "PUB00052561", "PUB00052562", "PUB00052563", "PUB00052564", "PUB00052565", "PUB00052566", "PUB00052567", "PUB00052568", "PUB00052569", "PUB00052570", "PUB00052571", "PUB00052572", "PUB00052573", "PUB00052574", "PUB00102275", "PUB001599...
[ "11914271", "17241905", "17825065", "1579162", "7585959", "16716188", "7892251", "7781615", "16228006", "10966477", "12045100", "15680967", "11572976", "11429609", "16024805", "8622770", "9171055", "32848132", "33298899" ]
[ "The origin recognition complex: from simple origins to complex functions.", "Multiple functions of the origin recognition complex.", "Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.", "ATP-dependent ...
[ 2002, 2007, 2007, 1992, 1995, 2006, 1995, 1995, 2005, 2000, 2002, 2005, 2001, 2001, 2005, 1996, 1997, 2020, 2020 ]
19
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4605 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 4, 1, 1, 1, 2, 3, 1, 1, 4, 1, 2, 4 ]
12
true
Domain
Origin recognition complex subunit 2, RecA-like domain
Origin recognition complex subunit 2, RecA-like domain
RecA-like_ORC2
8
IPR056774
56,774
FdhE, N-terminal domain
FdhE_N
Domain
3,407
false
false
This domain is found at the N-terminal of FdhE from Escherichia coli and similar proteins necessary for formate dehydrogenase activity. This domain shows a mainly α-helical configuration. This entry contains formate dehydrogenase accessory protein FdhE and its homologues, found largely in proteobacteria, where the fdhE...
[]
[]
[]
0
[ "PFAM" ]
[ "PF04216" ]
[ "FdhE_N" ]
[ 3407 ]
1
[]
[]
[]
0
[ "2fiy" ]
1
[ "PUB00009643", "PUB00013624", "PUB00013625", "PUB00104131", "PUB00106621" ]
[ "2170340", "8522521", "1648557", "9274019", "18716757" ]
[ "Identification and expression of the Escherichia coli fdhD and fdhE genes, which are involved in the formation of respiratory formate dehydrogenase.", "Expression and characterization of the Escherichia coli fdo locus and a possible physiological role for aerobic formate dehydrogenase.", "Genetic evidence that...
[ 1990, 1995, 1991, 1997, 2008 ]
5
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 3391, 5, 11 ]
3
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
FdhE, N-terminal domain
FdhE, N-terminal domain
FdhE_N
8
IPR056776
56,776
YABBY, N-terminal domain
YABBY_N
Domain
4,732
false
false
YABBY proteins are a group of plant-specific transcription involved in the specification of abaxial polarity in lateral organs [ , ]. This entry represents the N-terminal domain, which is found associated with .
[]
[]
[]
0
[ "PFAM" ]
[ "PF24868" ]
[ "YABBY_N" ]
[ 4732 ]
1
[]
[]
[]
0
[]
0
[ "PUB00008545", "PUB00008546" ]
[ "10679447", "11858837" ]
[ "The YABBY gene family and abaxial cell fate.", "Establishment of polarity in angiosperm lateral organs." ]
[ 2000, 2002 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4732 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 26, 23, 67 ]
3
true
Domain
YABBY, N-terminal domain
YABBY, N-terminal domain
YABBY_N
5
IPR056778
56,778
UPF0261, C-terminal domain
UPF0261_C
Domain
4,560
false
false
This entry represents the C-terminal domain of ToMV resistance protein Tm-1 and the uncharacterised UPF0261 proteins. The tomato resistance protein Tm-1, which inhibits replication complex formation through its binding to tomato mosaic virus (ToMV) replication proteins [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF23189" ]
[ "UPF0261_C" ]
[ 4560 ]
1
[]
[]
[]
0
[ "3wrw", "3wrx", "3wry", "9mpy" ]
4
[ "PUB00095035", "PUB00095036" ]
[ "25092327", "27647002" ]
[ "Structural basis for the recognition-evasion arms race between Tomato mosaic virus and the resistance gene Tm-1.", "Origin of the plant Tm-1-like gene via two independent horizontal transfer events and one gene fusion event." ]
[ 2014, 2016 ]
2
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 96, 2848, 1575, 41 ]
4
[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 6, 1, 2, 10 ]
4
true
Domain
UPF0261, C-terminal domain
UPF0261, C-terminal domain
UPF0261_C
4
IPR056779
56,779
Csf1, C-terminal region
Csf1_C
Domain
1,304
false
false
This entry represents the C-terminal region of Csf1. This entry includes Csf1 protein from yeast, which is the orthologue of human BLTP1. These are tube-forming lipid transport proteins which provide phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum [ ]. They ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25038" ]
[ "Csf1_C" ]
[ 1304 ]
1
[]
[]
[]
0
[]
0
[ "PUB00070565", "PUB00101861", "PUB00101862" ]
[ "10781556", "35491307", "35015055" ]
[ "Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae, which is required for nutrient uptake at low temperature.", "A novel superfamily of bridge-like lipid transfer proteins.", "Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER." ]
[ 2000, 2022, 2022 ]
3
[]
[]
0
0
null
[ "Fungi" ]
[ 1304 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]
[ 1, 1 ]
2
true
Domain
Csf1, C-terminal region
Csf1, C-terminal region
Csf1_C
8
IPR056782
56,782
Polynucleotide kinase, PNKP phosphatase domain
HAD_PNKP
Domain
2,952
false
false
This entry represents the C-terminal domain of the bifunctional enzyme polynucleotide kinase/phosphatase, PNKP (also known as PseT) from Enterobacteria phage T4. The PNKP phosphatase domain can catalyse the hydrolytic removal of the 3'-phosphoryl of DNA, RNA and deoxynucleoside 3'-monophosphates [ , ]. Members of this ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25109" ]
[ "HAD_PNKP" ]
[ 2952 ]
1
[]
[]
[]
0
[ "1ltq", "1ly1", "1rc8", "1rpz", "1rrc", "2ia5", "4xrp", "4xru", "5uj0" ]
9
[ "PUB00041648", "PUB00154001" ]
[ "17493655", "25882814" ]
[ "Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase.", "Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex." ]
[ 2007, 2015 ]
2
[ "IPR044493" ]
[]
1
0
1
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 11, 1818, 4, 1067, 52 ]
5
[]
[]
0
true
Domain
Polynucleotide kinase, PNKP phosphatase domain
Polynucleotide kinase, PNKP phosphatase domain
HAD_PNKP
1
IPR056784
56,784
DNA replication complex GINS protein PSF2, N-terminal domain
PSF2_N
Domain
3,897
false
false
This domain is found N-terminal in the human DNA replication complex GINS protein PSF2 and related eukaryotic proteins. PSF2 is an essential component of of the GINS complex, which plays an essential role in the initiation of DNA replication, and progression of DNA replication forks [ ].
[]
[]
[]
0
[ "PFAM", "CDD" ]
[ "PF25005", "cd21694" ]
[ "PSF2_N", "GINS_B_Psf2" ]
[ 3878, 3697 ]
2
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-176974", "R-DDI-176974", "R-DME-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974", "R-SPO-176974" ]
[ "REACTOME:R-CEL-176974", "REACTOME:R-DDI-176974", "REACTOME:R-DME-176974", "REACTOME:R-HSA-176974", "REACTOME:R-MMU-176974", "REACTOME:R-SCE-176974", "REACTOME:R-SPO-176974" ]
7
[ "2e9x", "2eho", "2q9q", "3jc5", "3jc6", "3jc7", "5u8s", "5u8t", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6skl", "6u0m", "6xtx", "6xty", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8b9a", "8b9b", "8b9c", "8b9d", "8kg6", "8kg8"...
46
[ "PUB00015004", "PUB00040384", "PUB00040400", "PUB00044029", "PUB00085134", "PUB00088355", "PUB00088356", "PUB00128703", "PUB00147356", "PUB00147357", "PUB00147358" ]
[ "12730134", "17417653", "17545466", "17652513", "20070258", "17467990", "21799014", "18509549", "16077978", "30013653", "22993141" ]
[ "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.", "Structure of the human GINS complex and its assembly and functional interface in replication initiation.", "Crystal structure of the human GINS complex.", "Crystal structure of the GINS complex and functional ins...
[ 2003, 2007, 2007, 2007, 2010, 2007, 2011, 2008, 2005, 2018, 2012 ]
11
[]
[]
0
0
null
[ "Ciceribacter ferrooxidans", "Eukaryota", "miscellaneous Crenarchaeota group-1 archaeon SG8-32-1" ]
[ 1, 3895, 1 ]
3
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 6, 1, 1, 1, 2, 1, 1, 4, 2, 1, 1, 11 ]
12
true
Domain
DNA replication complex GINS protein PSF2, N-terminal domain
DNA replication complex GINS protein PSF2, N-terminal domain
PSF2_N
9
IPR056785
56,785
Putative mannosyltransferase YkcA/B-like, C-terminal
YkcA/B-like_C
Domain
4,923
false
false
This domain is found at the C-terminal end of the putative mannosyltransferases YkcA and YkcB from Bacillus subtilis and similar sequences. This domain is predicted to adopt an α-β configuration. It is usually found associated with .
[]
[]
[]
0
[ "PFAM" ]
[ "PF24878" ]
[ "YkcB_C" ]
[ 4923 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Phytophthora kernoviae 00238/432", "Stenosarchaea group", "metagenomes" ]
[ 4906, 1, 5, 11 ]
4
[]
[]
0
true
Domain
Putative mannosyltransferase YkcA/B-like, C-terminal
Putative mannosyltransferase YkcA/B-like, C-terminal
YkcA/B-like_C
3
IPR056787
56,787
3'-5' exoribonuclease HELZ2, OB-fold domain
OB_HELZ2
Domain
1,375
false
false
This domain is found in human 3'-5' exoribonuclease HELZ2 and similar animal proteins. HELZ2 can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25049" ]
[ "OB_HELZ2" ]
[ 1375 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-1368108", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-381340", "R-HSA-400206", "R-HSA-9707564", "R-HSA-9707616", "R-HSA-9931509", "R-HSA-9933387", "R-MMU-400206", "R-MMU-9707564" ]
[ "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-2426168", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-400206", "REACTOME:R-HSA-9707564", "REACTOME:R-HSA-9707616", "REACTOME:R-HSA-9931509", "REACTOME:R-HSA-9933387", "REACTOME:R-MMU-400206", "REACTOME:R...
12
[]
0
[ "PUB00159917" ]
[ "37602378" ]
[ "HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon." ]
[ 2023 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1375 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 6, 3, 5, 7 ]
4
true
Domain
3'-5' exoribonuclease HELZ2, OB-fold domain
3'-5' exoribonuclease HELZ2, OB-fold domain
OB_HELZ2
2
IPR056788
56,788
ABC transporter A family member 2/9/11, C-terminal domain
ABCA2/9/11_C
Domain
1,025
false
false
This domain is found towards the C-terminal of ABC transporter A family members 2/9/11 from Arabidopsis thaliana and similar plant proteins. This domain is predicted to adopt a mainly β structure. ABCA9 mediates the transport of acyl-CoAs and/or free fatty acids to the endoplasmic reticulum. It has no effect on the sel...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25158" ]
[ "ABCA11_C" ]
[ 1025 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159969", "PUB00159970" ]
[ "23269834", "37291904" ]
[ "AtABCA9 transporter supplies fatty acids for lipid synthesis to the endoplasmic reticulum.", "Arabidopsis thaliana rosette habit is controlled by combined light and energy signaling converging on transcriptional control of the TALE homeobox gene ATH1." ]
[ 2013, 2023 ]
2
[]
[]
0
0
null
[ "Viridiplantae" ]
[ 1025 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 13, 2, 6 ]
3
true
Domain
ABC transporter A family member 2/9/11, C-terminal domain
ABC transporter A family member 2/9/11, C-terminal domain
ABCA2/9/11_C
7
IPR056789
56,789
R13L1/DRL21-like, LRR repeat region
LRR_R13L1-DRL21
Domain
28,920
false
false
This entry represents a region of leucine-rich repeats (LRRs) found in R13L1, DRL21 from Arabidopsis thaliana and related plant proteins. R13L1 and DRL21 are likely disease resistance proteins. DRL21 has adenylate cyclase activity [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25019" ]
[ "LRR_R13L1-DRL21" ]
[ 28920 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159910" ]
[ "31850369" ]
[ "New Perspectives on Plant Adenylyl Cyclases." ]
[ 2019 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Promethearchaeum syntrophicum" ]
[ 29, 28890, 1 ]
3
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 13, 446, 224 ]
3
true
Domain
R13L1/DRL21-like, LRR repeat region
R13L1/DRL21-like, LRR repeat region
LRR_R13L1-DRL21
4
IPR056790
56,790
Ribophorin II, C-terminal domain
Ribophorin_II_C
Domain
5,200
false
false
This domain is found at the C-terminal of human Ribophorin II (RPN2, also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2), a subunit of the oligosaccharyl transferase (OST) complex that catalyses the first step in protein N-glycosylation. This domain shows a non-compact all-α configur...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25147" ]
[ "Ribophorin_II_C" ]
[ 5200 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-1799339", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-9768727" ]
[ "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-446203", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-9768727", "REACTOME:R-MMU-9768727", "REACTOME:R-RNO-9768727" ]
6
[ "6c26", "6ezn", "6s7o", "6s7t", "7oci", "8agb", "8agc", "8age", "8b6l", "8pn9" ]
10
[ "PUB00155777", "PUB00159927", "PUB00159928" ]
[ "29466327", "36435935", "38670073" ]
[ "The atomic structure of a eukaryotic oligosaccharyltransferase complex.", "Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.", "Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to N...
[ 2018, 2022, 2024 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5200 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 6, 1, 2, 2, 5, 4, 1, 2, 8, 1, 1, 17 ]
12
true
Domain
Ribophorin II, C-terminal domain
Ribophorin II, C-terminal domain
Ribophorin_II_C
8
IPR056791
56,791
Mcm10, C-terminal zinc binding motif
Znf_Mcm10_C
Domain
1,333
false
false
This is the C-terminal zinc binding motif of Mcm10, an eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha. This motif is structurally similar to the zinc-ribbon domain found in the N-terminal domain of eukaryotic and archaeal MCM helicases [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF09332" ]
[ "Mcm10" ]
[ 1333 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DME-176187", "R-DME-68962", "R-HSA-176187", "R-HSA-68962", "R-MMU-176187", "R-MMU-68962", "R-XTR-68962" ]
[ "REACTOME:R-DME-176187", "REACTOME:R-DME-68962", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-68962", "REACTOME:R-MMU-176187", "REACTOME:R-MMU-68962", "REACTOME:R-XTR-68962" ]
7
[ "2kwq" ]
1
[ "PUB00035418", "PUB00066046" ]
[ "15494305", "20489205" ]
[ "Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.", "Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif." ]
[ 2004, 2010 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1333 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 2, 2, 1, 3 ]
6
true
Domain
Mcm10, C-terminal zinc binding motif
Mcm10, C-terminal zinc binding motif
Znf_Mcm10_C
4
IPR056792
56,792
Ribosome maturation factor RimM, PRC barrel domain
PRC_RimM
Domain
19,917
false
false
This entry represents a PRC-barrel domain found in the RimM protein family. The RimM family comprises ribosome maturation factors essential for the final assembly of the 30S ribosomal subunit, particularly the head region. These proteins facilitate the efficient processing of 16S rRNA and may function both before and a...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24986" ]
[ "PRC_RimM" ]
[ 19917 ]
1
[]
[]
[]
0
[ "2f1l", "2qgg", "3h9n", "7cq1" ]
4
[ "PUB00106684", "PUB00109784", "PUB00159971", "PUB00159972" ]
[ "15496525", "27382067", "20188109", "23611982" ]
[ "The PRC-barrel domain of the ribosome maturation protein RimM mediates binding to ribosomal protein S19 in the 30S ribosomal subunits.", "Binding properties of YjeQ (RsgA), RbfA, RimM and Era to assembly intermediates of the 30S subunit.", "The effect of ribosome assembly cofactors on in vitro 30S subunit reco...
[ 2004, 2016, 2010, 2013 ]
4
[]
[]
0
0
null
[ "Bacteria", "Escherichia phage vB_EcoM-613R3", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA382M17", "unclassified sequences" ]
[ 18900, 1, 571, 1, 444 ]
5
[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 1, 3, 6 ]
3
true
Domain
Ribosome maturation factor RimM, PRC barrel domain
Ribosome maturation factor RimM, PRC barrel domain
PRC_RimM
7
IPR056793
56,793
Heparan sulfate-N-deacetylase, N-terminal domain
HSNSD_N
Domain
5,286
false
false
This entry represents the N-terminal domain of Bifunctional heparan sulfate N-deacetylase/N-sulfotransferases, which is related to the N-terminal domain of Agd3 from A. fumigatus [ ], a carbohydrate binding module (CBM), the founding member of CBM family 87. This domain is found associated with .
[]
[]
[]
0
[ "PFAM" ]
[ "PF25119" ]
[ "HSNSD_N" ]
[ 5286 ]
1
[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.8.2.-", "2.8.2.8", "PWY-6546", "PWY-6558", "PWY-6567", "PWY-6568", "PWY-7831", "PWY-8045", "PWY-8358", "PWY-8381", "R-CEL-2022928", "R-DME-2022928", "R-HSA-2022928", "R-MMU-2022928", "R-RNO-2022928" ]
[ "EC:2.8.2.-", "EC:2.8.2.8", "METACYC:PWY-6546", "METACYC:PWY-6558", "METACYC:PWY-6567", "METACYC:PWY-6568", "METACYC:PWY-7831", "METACYC:PWY-8045", "METACYC:PWY-8358", "METACYC:PWY-8381", "REACTOME:R-CEL-2022928", "REACTOME:R-DME-2022928", "REACTOME:R-HSA-2022928", "REACTOME:R-MMU-2022928"...
15
[ "8ccy", "8cd0", "8chs", "9f6z" ]
4
[ "PUB00159906" ]
[ "38351061" ]
[ "Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1." ]
[ 2024 ]
1
[]
[]
0
0
null
[ "Metazoa" ]
[ 5286 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 28, 3, 10, 8, 12 ]
6
true
Domain
Heparan sulfate-N-deacetylase, N-terminal domain
Heparan sulfate-N-deacetylase, N-terminal domain
HSNSD_N
9
IPR056794
56,794
Patellin-1-6, C-terminal GOLD domain
PATL1-6_C_GOLD
Domain
3,524
false
false
This GOLD domain is found at the C-terminal end of Patellin-1-6 from Arabidopsis thaliana (PATL1-6) and similar plant proteins. PATL1 is a carrier protein that may be involved in membrane -trafficking events associated with cell plate formation during cytokinesis. It binds to some hydrophobic molecules and promotes the...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25099" ]
[ "GOLD_PATL1_C" ]
[ 3524 ]
1
[]
[]
[]
0
[]
0
[ "PUB00097179" ]
[ "15466235" ]
[ "Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides." ]
[ 2004 ]
1
[ "IPR009038" ]
[]
1
0
1
[ "Eukaryota" ]
[ 3524 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 30, 12, 38 ]
3
true
Domain
Patellin-1-6, C-terminal GOLD domain
Patellin-1-6, C-terminal GOLD domain
PATL1-6_C_GOLD
5
IPR056795
56,795
PAC1-like, LisH-like dimerisation domain
PAC1-like_LisH-like_dom
Domain
3,685
false
false
This entry represents a presumed LisH-like dimerisation domain found at the N terminus of the Nuclear distribution protein PAC1 and related proteins, including Lissencephaly-1 homolog (Lis1) and Nuclear distribution protein nudF. PAC1 is the yeast homologue of Lis1, which positively regulates the activity of the minus-...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24951" ]
[ "LisH_PAC1" ]
[ 3685 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-CEL-6811436", "R-DME-6811436", "R-DRE-6811436", "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-2565942", "R-GGA-380259", "R-GGA-380270", "R-GGA-380284", "R-GGA-380320", "R-GGA-5620912", "R-GGA-5663220", "R-GGA-6811436", "R-GGA-8854518", "R-GGA-9648025", "R-HSA-141444", ...
[ "REACTOME:R-CEL-6811436", "REACTOME:R-DME-6811436", "REACTOME:R-DRE-6811436", "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-2565942", "REACTOME:R-GGA-380259", "REACTOME:R-GGA-380270", "REACTOME:R-GGA-380284", "REACTOME:R-GGA-380320", "REACTOME:R-G...
71
[ "1uuj", "1vyh", "8dyu", "8dyv", "8fdt", "8fdu", "8pqw", "8pqy", "8pqz", "8ptk", "9dzy", "9e0t", "9e0w", "9e0z", "9e11", "9e13", "9e14", "9e22" ]
18
[ "PUB00155916", "PUB00160267", "PUB00160268", "PUB00160269" ]
[ "20005871", "11685578", "15254012", "15331665" ]
[ "UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.", "Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans.", "Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotr...
[ 2010, 2001, 2004, 2004 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3685 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]
[ 1, 3, 2, 8, 9, 2, 2 ]
7
true
Domain
PAC1-like, LisH-like dimerisation domain
PAC1-like, LisH-like dimerisation domain
PAC1-like_LisH-like_dom
3
IPR056796
56,796
FdhE, C-terminal domain
FdhE_C
Domain
3,684
false
false
This is the C-terminal domain of FdhE from Escherichia coli and similar proteins necessary for formate dehydrogenase activity. This domain is found associated with and . It shows an α-β configuration ( ). This entry contains formate dehydrogenase accessory protein FdhE and its homologues, found largely in proteobacteri...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24860" ]
[ "FdhE_C" ]
[ 3684 ]
1
[]
[]
[]
0
[ "2fiy" ]
1
[ "PUB00009643", "PUB00013624", "PUB00104131", "PUB00106621" ]
[ "2170340", "8522521", "9274019", "18716757" ]
[ "Identification and expression of the Escherichia coli fdhD and fdhE genes, which are involved in the formation of respiratory formate dehydrogenase.", "Expression and characterization of the Escherichia coli fdo locus and a possible physiological role for aerobic formate dehydrogenase.", "Suppression of Escher...
[ 1990, 1995, 1997, 2008 ]
4
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 3652, 7, 25 ]
3
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
FdhE, C-terminal domain
FdhE, C-terminal domain
FdhE_C
8
IPR056797
56,797
FdhE, central domain
FdhE_central
Domain
3,646
false
false
This is the central domain of FdhE from Escherichia coli and similar bacterial proteins necessary for formate dehydrogenase activity. This domain is found associated with and . This entry contains formate dehydrogenase accessory protein FdhE and its homologues, found largely in proteobacteria, where the fdhE genes are ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24859" ]
[ "FdhE_central" ]
[ 3646 ]
1
[]
[]
[]
0
[ "2fiy" ]
1
[ "PUB00009643", "PUB00013624", "PUB00104131", "PUB00106621" ]
[ "2170340", "8522521", "9274019", "18716757" ]
[ "Identification and expression of the Escherichia coli fdhD and fdhE genes, which are involved in the formation of respiratory formate dehydrogenase.", "Expression and characterization of the Escherichia coli fdo locus and a possible physiological role for aerobic formate dehydrogenase.", "Suppression of Escher...
[ 1990, 1995, 1997, 2008 ]
4
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Thermoproteati", "metagenomes" ]
[ 3609, 7, 3, 27 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
FdhE, central domain
FdhE, central domain
FdhE_central
9
IPR056798
56,798
Fe-containing alcohol dehydrogenase-like, C-terminal
ADH_Fe_C
Domain
63,745
false
false
This domain is found C-terminal in iron-containing alcohol dehydrogenases from all cellular organisms, mainly bacteria. It is usually found associated with and . It folds into an array of α-helices [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25137" ]
[ "ADH_Fe_C" ]
[ 63745 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-880009", "R-CEL-880009", "R-DDI-880009", "R-DME-880009", "R-HSA-880009", "R-MMU-880009", "R-RNO-880009", "R-XTR-880009" ]
[ "REACTOME:R-BTA-880009", "REACTOME:R-CEL-880009", "REACTOME:R-DDI-880009", "REACTOME:R-DME-880009", "REACTOME:R-HSA-880009", "REACTOME:R-MMU-880009", "REACTOME:R-RNO-880009", "REACTOME:R-XTR-880009" ]
8
[ "1o2d", "1oj7", "1rrm", "1vhd", "1vlj", "2bi4", "2bl4", "3bfj", "3hl0", "3iv7", "3jzd", "3owo", "3ox4", "3rf7", "3w5s", "3zdr", "4fr2", "4qgs", "5br4", "5k8c", "5yvm", "5yvr", "5yvs", "6ahc", "6c75", "6c76", "6c7l", "6jko", "6jkp", "6l1k", "6scg", "6sci"...
61
[ "PUB00123795", "PUB00159876" ]
[ "21295587", "31586059" ]
[ "Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 with and without NAD+ cofactor.", "Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity." ]
[ 2011, 2019 ]
2
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Escherichia phage phi456", "Eukaryota", "Sym plasmid", "unclassified sequences" ]
[ 896, 55478, 1, 6664, 1, 705 ]
6
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", ...
[ 1, 1, 3, 5, 2, 2, 1, 5, 1, 2 ]
10
true
Domain
Fe-containing alcohol dehydrogenase-like, C-terminal
Fe-containing alcohol dehydrogenase-like, C-terminal
ADH_Fe_C
5
IPR056799
56,799
Aegyptin/gSG7 salivary protein-like, four-helix bundle
ALL3/gSG7_salivary-like_helix
Domain
239
false
false
This entry represents a four-helix bundle found at the C-terminal of Aegyptin and salivary IL-4-inducing protein from Aedes aegypti and as the only structural domain in gSG7 salivary protein from Anopheles sp. Aegyptin modulates blood feeding of female mosquitoes on vertebrate hosts [ ]. This domain is predicted to ado...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25001" ]
[ "Aegyptin_C" ]
[ 239 ]
1
[]
[]
[]
0
[ "4okv", "6xke", "6xl7", "6xmb", "8uh2", "8uin" ]
6
[ "PUB00154488", "PUB00159877", "PUB00159977", "PUB00159978", "PUB00160038" ]
[ "24778255", "33199367", "19493208", "27307559", "24921659" ]
[ "Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti.", "Salivary complement inhibitors from mosquitoes: Structure and mechanism of action.", "SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-...
[ 2014, 2021, 2009, 2016, 2014 ]
5
[]
[]
0
0
null
[ "Arthropoda" ]
[ 239 ]
1
[]
[]
0
true
Domain
Aegyptin/gSG7 salivary protein-like, four-helix bundle
Aegyptin/gSG7 salivary protein-like, four-helix bundle
ALL3/gSG7_salivary-like_helix
9
IPR056800
56,800
RNA-binding protein RO60, vWA domain
vWA_Ro60
Domain
3,533
false
false
This entry represents the vWA domain of RNA-binding protein RO60 which is found after the TROVE domain at the N-terminal end [ , , ]. RO60 binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs [ , ]. This domain closes the ring from the TROVE domain.
[]
[]
[]
0
[ "PFAM" ]
[ "PF25045" ]
[ "vWA_Ro60" ]
[ 3533 ]
1
[]
[]
[]
0
[ "1yvp", "1yvr", "2i91", "2nvo" ]
4
[ "PUB00038651", "PUB00041640", "PUB00048398", "PUB00090817", "PUB00100198" ]
[ "15907467", "17041599", "17392270", "18056422", "26382853" ]
[ "Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.", "Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen.", "Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA bi...
[ 2005, 2006, 2007, 2007, 2015 ]
5
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]
[ 1534, 1861, 13, 103, 22 ]
5
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 3, 3, 4, 4 ]
6
true
Domain
RNA-binding protein RO60, vWA domain
RNA-binding protein RO60, vWA domain
vWA_Ro60
5
IPR056801
56,801
SBSPON-like, C-terminal
SBSPON_C
Domain
1,932
false
false
This domain is found at the C-terminal end of human Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON) and similar animal sequences. This domain is usually found associated with .
[]
[]
[]
0
[ "PFAM" ]
[ "PF25031" ]
[ "SBSPON_C" ]
[ 1932 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-5173214", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]
[ "REACTOME:R-BTA-5173214", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]
4
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eumetazoa" ]
[ 1932 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 4, 1, 1, 2 ]
5
true
Domain
SBSPON-like, C-terminal
SBSPON-like, C-terminal
SBSPON_C
8
IPR056802
56,802
Serine/threonine-protein kinase ATR-like, M-HEAT region
ATR-like_M-HEAT
Domain
4,421
false
false
This region of HEAT repeats is found in human Serine/threonine-protein kinase ATR and similar eukaryotic proteins. This entry represents the M-HEAT region. This region is also found in Serine/threonine-protein kinase MEC1 from Saccharomyces cerevisiae, which activates checkpoint signalling upon genotoxic stresses such ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25030" ]
[ "M-HEAT_ATR" ]
[ 4421 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "2.7.11.1", "R-DDI-2559586", "R-DDI-349425", "R-DDI-5693548", "R-DDI-5693565", "R-DDI-6804756", "R-DDI-6804760", "R-DDI-9664873", "R-DME-176187", "R-DME-5693607", "R-DME-6804756", "R-DME-69473", "R-HSA-1221632", "R-HSA-176187", "R-HSA-3371453", "R-HSA-5685938", "R-HSA-5693607", "R-...
[ "EC:2.7.11.1", "REACTOME:R-DDI-2559586", "REACTOME:R-DDI-349425", "REACTOME:R-DDI-5693548", "REACTOME:R-DDI-5693565", "REACTOME:R-DDI-6804756", "REACTOME:R-DDI-6804760", "REACTOME:R-DDI-9664873", "REACTOME:R-DME-176187", "REACTOME:R-DME-5693607", "REACTOME:R-DME-6804756", "REACTOME:R-DME-69473...
29
[ "5x6o", "5yz0", "6z2w", "6z2x", "6z3a", "7wzr", "7wzw", "9l40", "9l43", "9l45", "9l46", "9l4b", "9l4c", "9l4d", "9l4f" ]
15
[ "PUB00062181", "PUB00062182", "PUB00062291", "PUB00155647", "PUB00159981" ]
[ "8553072", "11095737", "16365046", "29271416", "15369670" ]
[ "Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.", "Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.", "Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like ...
[ 1996, 2000, 2006, 2018, 2004 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4421 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...
[ 6, 1, 1, 2, 3, 1, 2, 2, 1, 1, 14 ]
11
true
Domain
Serine/threonine-protein kinase ATR-like, M-HEAT region
Serine/threonine-protein kinase ATR-like, M-HEAT region
ATR-like_M-HEAT
4
IPR056803
56,803
Serine/threonine-protein kinase ATR-like, N-HEAT region
ATR-like_N-HEAT
Domain
934
false
false
This region of HEAT repeats is found in human Serine/threonine-protein kinase ATR and similar proteins from vertebrates. This entry represents the N-HEAT region. ATR acts as a DNA damage sensor and is associated with severe disorders such as Seckel syndrome 1. This protein is organised into a large N-terminal α-solenoi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25032" ]
[ "N-HEAT_ATR" ]
[ 934 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.7.11.1", "R-HSA-1221632", "R-HSA-176187", "R-HSA-3371453", "R-HSA-5685938", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6783310", "R-HSA-6796648", "R-HSA-6804756", "R-HSA-69473", "R-HSA-9709570", "R-MMU-176187", "R-MMU-5685938", "R-MMU-5693607", "R-MMU-6783310", "R-MMU-6804756", "R...
[ "EC:2.7.11.1", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6783310", "REACTOME:R-HSA-6796648", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-970957...
18
[ "5yz0", "9l40", "9l43", "9l45", "9l46", "9l4b", "9l4c", "9l4d", "9l4f" ]
9
[ "PUB00155647" ]
[ "29271416" ]
[ "Cryo-EM structure of human ATR-ATRIP complex." ]
[ 2018 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 934 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 4, 7, 2 ]
4
true
Domain
Serine/threonine-protein kinase ATR-like, N-HEAT region
Serine/threonine-protein kinase ATR-like, N-HEAT region
ATR-like_N-HEAT
3
IPR056804
56,804
SESTD1-like, spectrin repeats region
Spectrin_SESTD1
Domain
1,771
false
false
This region of spectrin repeats is found in human SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) and similar animal proteins. SESTD1 is a regulator of the transient receptor potential channels TRPC4 and TRPC5 [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24915" ]
[ "Spectrin_SESTD1" ]
[ 1771 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159982" ]
[ "20164195" ]
[ "The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5." ]
[ 2010 ]
1
[]
[]
0
0
null
[ "Eumetazoa" ]
[ 1771 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 3, 5, 1, 2 ]
5
true
Domain
SESTD1-like, spectrin repeats region
SESTD1-like, spectrin repeats region
Spectrin_SESTD1
9
IPR056805
56,805
ACT domain-containing protein ACR9/10, C-terminal domain
ACT_ACR9/10_C
Domain
2,143
false
false
This ACT domain is found at the C-terminal of ACT domain-containing proteins ACR9/10 from from Arabidopsis thaliana and similar plant proteins. They may bind amino acids [ ]. Plant ACT DOMAIN REPEAT (ACR) proteins may also serve as nutrient sensors. ACR9 might function as a repressor in glucose (Glc) signalling pathway...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24926" ]
[ "ACT_ACR9_C" ]
[ 2143 ]
1
[]
[]
[]
0
[]
0
[ "PUB00090710", "PUB00159983" ]
[ "21861936", "36843191" ]
[ "The ACR11 encodes a novel type of chloroplastic ACT domain repeat protein that is coordinately expressed with GLN2 in Arabidopsis.", "Arabidopsis ACT DOMAIN REPEAT9 represses glucose signaling pathways." ]
[ 2011, 2023 ]
2
[]
[]
0
0
null
[ "Viridiplantae" ]
[ 2143 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 9, 8, 22 ]
3
true
Domain
ACT domain-containing protein ACR9/10, C-terminal domain
ACT domain-containing protein ACR9/10, C-terminal domain
ACT_ACR9/10_C
5
IPR056806
56,806
Stabilin-1/2, EGF-like domain
EGF_STAB1-2
Domain
1,841
false
false
This entry represents EGF-like domains found in Stabilin-1 and 2 (STAB1/2), proteins that act as a scavenger receptors for acetylated low density lipoproteins. They bind Gram-positive and Gram-negative bacteria and may play a role in defence against bacterial infection [ , ]. These proteins are also involved in the del...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24887" ]
[ "EGF_STAB1-2" ]
[ 1841 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-2142845", "R-HSA-2160916", "R-HSA-3000497", "R-MMU-2142845", "R-MMU-2160916", "R-MMU-3000497" ]
[ "REACTOME:R-HSA-2142845", "REACTOME:R-HSA-2160916", "REACTOME:R-HSA-3000497", "REACTOME:R-MMU-2142845", "REACTOME:R-MMU-2160916", "REACTOME:R-MMU-3000497" ]
6
[]
0
[ "PUB00115522", "PUB00115536" ]
[ "12077138", "16357325" ]
[ "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.", "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." ]
[ 2002, 2006 ]
2
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 1841 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 3, 16, 7 ]
4
true
Domain
Stabilin-1/2, EGF-like domain
Stabilin-1/2, EGF-like domain
EGF_STAB1-2
5
IPR056807
56,807
FHL1/2/3/5, N-terminal LIM domain
LIM_FHL1/2/3/5_N
Domain
4,705
false
false
This entry represents the N-terminal LIM domain of Four and a half LIM domains proteins 1/2/3/5 (FHL1/2/3/5) and related animal sequences. FHL3 is recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. FHL2 may function as a molecular transmitter linking various signalling pathwa...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25076" ]
[ "LIM_FHL2-3_N" ]
[ 4705 ]
1
[ "REACTOME" ]
[ "R-HSA-1989781" ]
[ "REACTOME:R-HSA-1989781" ]
1
[ "2miu" ]
1
[ "PUB00159909" ]
[ "28717008" ]
[ "The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling." ]
[ 2017 ]
1
[]
[]
0
0
null
[ "Bilateria" ]
[ 4705 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 9, 4, 35, 18, 25 ]
6
true
Domain
FHL1/2/3/5, N-terminal LIM domain
FHL1/2/3/5, N-terminal LIM domain
LIM_FHL1/2/3/5_N
5
IPR056808
56,808
AAA protein, C-terminal winged helix domain
HTH_AAA
Domain
1,799
false
false
This domain is found at the C-terminal end of a group of uncharacterised fungal proteins that contain the AAA ATPase domain at the N terminus. This domain is predicted to have a winged helix configuration.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24913" ]
[ "WHD_AAA_fung" ]
[ 1799 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1799 ]
1
[ "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1, 2 ]
2
true
Domain
AAA protein, C-terminal winged helix domain
AAA protein, C-terminal winged helix domain
HTH_AAA
1
IPR056809
56,809
GCN1-like, HEAT repeats
HEAT_GCN1_fung
Domain
1,730
false
false
This region of HEAT repeats is found in eIF-2-alpha kinase activator GCN1 from Saccharomyces cerevisiae and similar fungal sequences. GCN1 is a ribosome collision sensor that activates a translation quality control pathway when a ribosome has stalled during translation [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24916" ]
[ "HEAT_GCN1_fung" ]
[ 1730 ]
1
[]
[]
[]
0
[ "8i9x", "8i9y", "8i9z", "8ia0", "8onz", "8pv1", "8pv2", "8pv3", "8pv4", "8pv5", "8pv6", "8pv7", "8pv8", "8pvk", "8pvl" ]
15
[ "PUB00159899" ]
[ "33790014" ]
[ "Structure of Gcn1 bound to stalled and colliding 80S ribosomes." ]
[ 2021 ]
1
[]
[]
0
0
null
[ "Fungi" ]
[ 1730 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
GCN1-like, HEAT repeats
GCN1-like, HEAT repeats
HEAT_GCN1_fung
5
IPR056810
56,810
Stalled ribosome sensor GCN1-like, N-terminal
GNC1-like_N
Domain
4,432
false
false
This entry represents a region that consists of four HEAT repeats found towards the N-terminal of the stalled ribosome sensor GCN1, a ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and whi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24993" ]
[ "GNC1_N" ]
[ 4432 ]
1
[ "REACTOME" ]
[ "R-HSA-9633012" ]
[ "REACTOME:R-HSA-9633012" ]
1
[ "8i9x", "8i9y", "8i9z", "8ia0", "8onz", "8pv1", "8pv2", "8pv3", "8pv4", "8pv5", "8pv6", "8pv7", "8pv8", "8pvk", "8pvl" ]
15
[ "PUB00155654", "PUB00159901" ]
[ "32610081", "20360018" ]
[ "Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate.", "The HEAT repeat protein ILITYHIA is required for plant immunity." ]
[ 2020, 2010 ]
2
[]
[]
0
0
null
[ "Eukaryota", "Legionella maceachernii" ]
[ 4431, 1 ]
2
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 5, 1, 1, 2, 3, 3, 1, 3, 2, 1, 1, 10 ]
12
true
Domain
Stalled ribosome sensor GCN1-like, N-terminal
Stalled ribosome sensor GCN1-like, N-terminal
GNC1-like_N
8
IPR056812
56,812
RNA-binding domain, fungi
RRM_fung
Domain
1,011
false
false
This is a predicted RNA-binding domain, also known as RNA recognition motif (RRM) found in a group of uncharacterised proteins from fungi. This domain is often found associated with
[]
[]
[]
0
[ "PFAM" ]
[ "PF25061" ]
[ "RRM_fung" ]
[ 1011 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1011 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 2 ]
1
true
Domain
RNA-binding domain, fungi
RNA-binding domain, fungi
RRM_fung
3
IPR056813
56,813
GIL1/IRKI, C-terminal domain
GIL1_IRKI_C
Domain
4,613
false
false
This domain is found in the Protein GRAVITROPIC IN THE LIGHT 1 (GIL1), its paralogue IRK-interacting protein (IRKI) from Arabidopsis thaliana and related plant proteins. This domain is predicted to fold into a structure similar to head domain of nucleotide exchange factor GrpE ( ). GIL1 is essential for light-dependent...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24994" ]
[ "GIL1_IRKI_C" ]
[ 4613 ]
1
[]
[]
[]
0
[]
0
[ "PUB00090718" ]
[ "16640600" ]
[ "Phytochrome-mediated agravitropism in Arabidopsis hypocotyls requires GIL1 and confers a fitness advantage." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Embryophyta" ]
[ 4613 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 38, 27, 39 ]
3
true
Domain
GIL1/IRKI, C-terminal domain
GIL1/IRKI, C-terminal domain
GIL1_IRKI_C
7
IPR056814
56,814
GIPC1-3, GH1 domain
GIPC1-3_GH1
Domain
2,943
false
false
This entry represents the GIPC homology 1 (GH1) domain found in the GIPC proteins (GAIP interacting protein, C terminus) 1-3, PDZ domain-containing proteins, and similar animal sequences. GIPC1-3 may act as scaffold proteins linking heterotrimeric G-proteins to seven-transmembrane-type WNT receptor or to receptor tyros...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25083" ]
[ "GIPC1_GH1" ]
[ 2943 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-190370", "R-HSA-190373", "R-HSA-9839389", "R-HSA-9839397", "R-MMU-190370", "R-MMU-190373", "R-MMU-9839389", "R-MMU-9839397", "R-RNO-190370", "R-RNO-190373", "R-RNO-9839389", "R-RNO-9839397" ]
[ "REACTOME:R-HSA-190370", "REACTOME:R-HSA-190373", "REACTOME:R-HSA-9839389", "REACTOME:R-HSA-9839397", "REACTOME:R-MMU-190370", "REACTOME:R-MMU-190373", "REACTOME:R-MMU-9839389", "REACTOME:R-MMU-9839397", "REACTOME:R-RNO-190370", "REACTOME:R-RNO-190373", "REACTOME:R-RNO-9839389", "REACTOME:R-RN...
12
[ "5v6b", "5v6t" ]
2
[ "PUB00147342", "PUB00147343", "PUB00147348", "PUB00147349" ]
[ "26757732", "20634288", "11836571", "28537552" ]
[ "CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment.", "GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.", "Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2.", "Structure analyses reveal ...
[ 2016, 2010, 2002, 2017 ]
4
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 2943 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 6, 1, 9, 4, 9 ]
6
true
Domain
GIPC1-3, GH1 domain
GIPC1-3, GH1 domain
GIPC1-3_GH1
2
IPR056816
56,816
ACT domain-containing protein ACR9/10, N-terminal domain
ACR9/10_N
Domain
2,127
false
false
This is the ACT domain found at the N-terminal of ACT domain-containing protein ACR9/10 from Arabidopsis thaliana and similar plant proteins. They may bind amino acids [ ]. Plant ACT DOMAIN REPEAT (ACR) proteins may also serve as nutrient sensors. ACR9 might function as a repressor in glucose (Glc) signalling pathways....
[]
[]
[]
0
[ "PFAM" ]
[ "PF24914" ]
[ "ACR10_N" ]
[ 2127 ]
1
[]
[]
[]
0
[]
0
[ "PUB00090710", "PUB00159983" ]
[ "21861936", "36843191" ]
[ "The ACR11 encodes a novel type of chloroplastic ACT domain repeat protein that is coordinately expressed with GLN2 in Arabidopsis.", "Arabidopsis ACT DOMAIN REPEAT9 represses glucose signaling pathways." ]
[ 2011, 2023 ]
2
[]
[]
0
0
null
[ "Acetobacter conturbans", "Viridiplantae" ]
[ 1, 2126 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 9, 6, 24 ]
3
true
Domain
ACT domain-containing protein ACR9/10, N-terminal domain
ACT domain-containing protein ACR9/10, N-terminal domain
ACR9/10_N
5
IPR056818
56,818
Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like, C-terminal hexapeptide
GlmU/GlgC-like_hexapep
Domain
19,002
false
false
This domain is found at the C-terminal end of bacterial and plant glucose-1-phosphate adenylyltransferases (GlgC) and Bifunctional protein GlmU, including GlmU from Streptococcus pneumoniae. This domain is responsible for the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24894" ]
[ "Hexapep_GlmU" ]
[ 19002 ]
1
[ "EC", "METACYC", "METACYC" ]
[ "2.7.7.27", "PWY-622", "PWY-7902" ]
[ "EC:2.7.7.27", "METACYC:PWY-622", "METACYC:PWY-7902" ]
3
[ "3brk", "5l6s", "5l6v", "5mni", "5w5r", "5w5t", "5w6j", "6r8b", "6r8u", "6shj", "6shn", "6shq", "6si8", "6v96", "6v99", "6v9a", "6vr0" ]
17
[ "PUB00025708" ]
[ "11118459" ]
[ "Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture." ]
[ 2001 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 53, 18148, 539, 262 ]
4
[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Zea mays" ]
[ 2, 1, 4 ]
3
true
Domain
Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like, C-terminal hexapeptide
Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like, C-terminal hexapeptide
GlmU/GlgC-like_hexapep
7
IPR056819
56,819
Acyl-CoA-binding domain-containing protein 4-6, C-terminal
ACBP4-6_C
Domain
2,389
false
false
This entry represents a long α-helix found at the C terminus of the cytosolic acyl-CoA-binding domain-containing proteins 4/5 (ACBP4/5) from Arabidopsis and ACBP6 from rice. They play a role in the biosynthesis of membrane lipids including galactolipids and phospholipids. They bind medium- and long-chain acyl-CoA ester...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24922" ]
[ "ACBP4_C" ]
[ 2389 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159984", "PUB00159985", "PUB00159986" ]
[ "24738983", "31844833", "38501444" ]
[ "Subcellular localization of rice acyl-CoA-binding proteins (ACBPs) indicates that OsACBP6::GFP is targeted to the peroxisomes.", "Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition.", "ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia respons...
[ 2014, 2019, 2024 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2389 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 27, 13, 37 ]
3
true
Domain
Acyl-CoA-binding domain-containing protein 4-6, C-terminal
Acyl-CoA-binding domain-containing protein 4-6, C-terminal
ACBP4-6_C
6
IPR056820
56,820
Teneurin, TTR-like domain
TEN_TTR-like
Domain
9,446
false
false
This entry represents the transthyretin-like (TTR-like) domain found in animal teneurins, ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation [ ]. Teneurins are a family of phylogenetically conserved transmembrane glycoproteins expressed during pattern formation and morpho...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25020" ]
[ "TTR_TEN1-4" ]
[ 9446 ]
1
[]
[]
[]
0
[ "6cmx", "6fay", "6fb3", "6ska", "6vhh", "7bam", "7ban", "7bao", "8fia", "8r50", "8r51", "8r54" ]
12
[ "PUB00009650", "PUB00012632", "PUB00014529", "PUB00014530", "PUB00014531", "PUB00043665", "PUB00043666", "PUB00043667", "PUB00066375", "PUB00066378", "PUB00155423", "PUB00155629", "PUB00155630", "PUB00160051", "PUB00160052", "PUB00160053" ]
[ "10341219", "12783990", "11146505", "12361962", "10588872", "16406038", "17095284", "17502993", "23028443", "21724987", "29540701", "29414938", "25406022", "26188006", "27040985", "28472127" ]
[ "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.", "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.", "Teneurin-2 is expressed in tissues that regulate limb and...
[ 1999, 2003, 2001, 2002, 1999, 2006, 2007, 2007, 2012, 2011, 2018, 2018, 2015, 2015, 2016, 2017 ]
16
[]
[]
0
0
null
[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]
[ 150, 9293, 3 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 144, 7, 12, 11, 35 ]
6
true
Domain
Teneurin, TTR-like domain
Teneurin, TTR-like domain
TEN_TTR-like
8
IPR056822
56,822
Teneurin, NHL domain
TEN_NHL
Domain
11,717
false
false
This entry represents the NHL six-bladed β-propeller domain found in teneurins which packs against the TTR, FN and shell domains with the bottom face and is held in place by the FN domain which acts as a wedge to position the NHL at an angle perpendicular to the YD-shell domain [ ]. The top face of the NHL propeller co...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25021" ]
[ "TEN_NHL" ]
[ 11717 ]
1
[]
[]
[]
0
[ "6cmx", "6fay", "6fb3", "6ska", "6ske", "6vhh", "7bam", "7ban", "7bao", "8fia", "8r50", "8r51", "8r54" ]
13
[ "PUB00009650", "PUB00012632", "PUB00014529", "PUB00014530", "PUB00014531", "PUB00043665", "PUB00043666", "PUB00043667", "PUB00066375", "PUB00066378", "PUB00155423", "PUB00155629", "PUB00155630", "PUB00160051", "PUB00160052", "PUB00160053" ]
[ "10341219", "12783990", "11146505", "12361962", "10588872", "16406038", "17095284", "17502993", "23028443", "21724987", "29540701", "29414938", "25406022", "26188006", "27040985", "28472127" ]
[ "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.", "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.", "Teneurin-2 is expressed in tissues that regulate limb and...
[ 1999, 2003, 2001, 2002, 1999, 2006, 2007, 2007, 2012, 2011, 2018, 2018, 2015, 2015, 2016, 2017 ]
16
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 1320, 10329, 68 ]
3
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 8, 3, 146, 7, 12, 11, 35 ]
7
true
Domain
Teneurin, NHL domain
Teneurin, NHL domain
TEN_NHL
9
IPR056823
56,823
Teneurin-like, YD-shell
TEN-like_YD-shell
Domain
34,897
false
false
This entry represents the YD-shell domain found in Teneurins which forms a hollow tube, consisting of a single up-and-down spiralling β-sheet with 78 strands [ ] and shows similarity to structures of bacterial toxin complexes TcB-TcC. This domain is the most structurally conserved region of Teneurins and the TcB-TcC to...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25023" ]
[ "TEN_YD-shell" ]
[ 34897 ]
1
[]
[]
[]
0
[ "6cmx", "6fay", "6fb3", "6ska", "6ske", "6vhh", "7bam", "7ban", "7bao", "7pq5", "7q97", "8fia", "8h8a", "8h8b", "8h8c", "8qja", "8qjb", "8qjc", "8qjd", "8r50", "8r51", "8r54", "8uxt", "8uy4" ]
24
[ "PUB00009650", "PUB00012632", "PUB00014529", "PUB00014530", "PUB00014531", "PUB00043665", "PUB00043666", "PUB00043667", "PUB00066375", "PUB00066378", "PUB00155423", "PUB00155629", "PUB00155630", "PUB00160051", "PUB00160052", "PUB00160053" ]
[ "10341219", "12783990", "11146505", "12361962", "10588872", "16406038", "17095284", "17502993", "23028443", "21724987", "29540701", "29414938", "25406022", "26188006", "27040985", "28472127" ]
[ "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.", "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.", "Teneurin-2 is expressed in tissues that regulate limb and...
[ 1999, 2003, 2001, 2002, 1999, 2006, 2007, 2007, 2012, 2011, 2018, 2018, 2015, 2015, 2016, 2017 ]
16
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]
[ 43, 24293, 3, 10407, 151 ]
5
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 146, 8, 4, 15, 13, 34 ]
7
true
Domain
Teneurin-like, YD-shell
Teneurin-like, YD-shell
TEN-like_YD-shell
2
IPR056825
56,825
Agd3, C-terminal domain
Agd3_C
Domain
876
false
false
This entry represents the C-terminal domain of the exopolysaccharide deacetylase Agd3 from Aspergillus fumigatus ( ) a protein required for biofilm formation [ ]. It forms six β-strands in a seven-stranded β-sandwich, whose function is unknown [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25117" ]
[ "Agd3_C" ]
[ 876 ]
1
[]
[]
[]
0
[ "6nwz" ]
1
[ "PUB00159878" ]
[ "32415073" ]
[ "Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 876 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Agd3, C-terminal domain
Agd3, C-terminal domain
Agd3_C
1
IPR056826
56,826
Agd3, deacetylase domain
Agd3_CE
Domain
1,200
false
false
This entry represents the carbohydrate esterase (CE) domain of the exopolysaccharide deacetylase Agd3 from Aspergillus fumigatus ( ), a protein required for biofilm formation [ ]. This domain has structural similarity to members of the carbohydrate esterase family (CE4) but the amino acid sequences is too divergent and...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25115" ]
[ "Agd3_CE" ]
[ 1200 ]
1
[]
[]
[]
0
[ "6nwz" ]
1
[ "PUB00159878" ]
[ "32415073" ]
[ "Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 193, 1007 ]
2
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Agd3, deacetylase domain
Agd3, deacetylase domain
Agd3_CE
9
IPR056827
56,827
Agd3, CBM87
CBM87_Agd3
Domain
1,221
false
false
This entry represents the carbohydrate binding module (CBM) domain found at the N-terminal of the exopolysaccharide deacetylase Agd3 from Aspergillus fumigatus ( ), a protein required for biofilm formation [ ]. This is the founding member of CBM family 87 [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF25116" ]
[ "CBM87_Agd3" ]
[ 1221 ]
1
[]
[]
[]
0
[ "6nwz" ]
1
[ "PUB00159878" ]
[ "32415073" ]
[ "Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]
[ 250, 970, 1 ]
3
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Agd3, CBM87
Agd3, CBM87
CBM87_Agd3
3
IPR056828
56,828
TEP-1, C-terminal beta-propeller
Beta-prop_TEP1_C
Domain
863
false
false
This entry represents the β-propeller found at the C-terminal of Telomerase protein component 1 (TEP1), a component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini [ ]. It is also a component of the ribonucleoprotein vaults particle, a multi-subunit structure invo...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25048" ]
[ "Beta-prop_TEP1_C" ]
[ 863 ]
1
[]
[]
[]
0
[]
0
[ "PUB00035328", "PUB00091065" ]
[ "11149928", "19179534" ]
[ "The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.", "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis." ]
[ 2001, 2009 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanosarcina barkeri", "ecological metagenomes" ]
[ 66, 793, 2, 2 ]
4
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 3, 6 ]
4
true
Domain
TEP-1, C-terminal beta-propeller
TEP-1, C-terminal beta-propeller
Beta-prop_TEP1_C
5
IPR056829
56,829
TEP-1, second beta-propeller
Beta-prop_TEP1_2nd
Domain
1,324
false
false
This entry represents the second of three presumed β-propeller domains found at the C-terminal of Telomerase protein component 1 (TEP1), a component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini [ ]. It is also a component of the ribonucleoprotein vaults particl...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25047" ]
[ "Beta-prop_TEP1_2nd" ]
[ 1324 ]
1
[]
[]
[]
0
[]
0
[ "PUB00035328", "PUB00091065" ]
[ "11149928", "19179534" ]
[ "The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.", "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis." ]
[ 2001, 2009 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 63, 1261 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 5, 4, 9 ]
4
true
Domain
TEP-1, second beta-propeller
TEP-1, second beta-propeller
Beta-prop_TEP1_2nd
6
IPR056832
56,832
Tetratricopeptide repeat protein 21A/21B, second ARM domain
ARM_TT21_2nd
Domain
2,926
false
false
This entry represents the second ARM-repeats domain found towards the N-terminal of Tetratricopeptide repeat protein 21A (TTC21A) and 21B (TTC21B) from human and its homologues. TTC21A/B are intraflagellar transport (IFT)-associated proteins required for spermatogenesis. TTC21A is involved in sperm flagellar formation ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25060" ]
[ "ARM_TT21_2nd" ]
[ 2926 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924" ]
6
[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8hmc", "8hmd", "8ruy" ]
9
[ "PUB00089704", "PUB00090860", "PUB00159879" ]
[ "20889716", "21258341", "30929735" ]
[ "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.", "Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice." ]
[ 2010, 2011, 2019 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacterium lacus (strain AL-21)", "ecological metagenomes" ]
[ 85, 2838, 1, 2 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 1, 16, 5, 5 ]
5
true
Domain
Tetratricopeptide repeat protein 21A/21B, second ARM domain
Tetratricopeptide repeat protein 21A/21B, second ARM domain
ARM_TT21_2nd
1
IPR056833
56,833
Tetratricopeptide repeat protein 21A/21B, N-terminal ARM repeat
ARM_TT21_N
Domain
2,924
false
false
This entry represents the N-terminal segment of ARM repeats of Tetratricopeptide repeat protein 21A (TTC21A) and 21B (TTC21B) from human and its homologues. TTC21A/B are intraflagellar transport (IFT)-associated proteins required for spermatogenesis. TTC21A is involved in sperm flagellar formation and intraflagellar tr...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25062" ]
[ "ARM_TT21_N" ]
[ 2924 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924" ]
6
[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8hmc", "8hmd", "8ruy" ]
9
[ "PUB00089704", "PUB00090860", "PUB00159879" ]
[ "20889716", "21258341", "30929735" ]
[ "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.", "Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice." ]
[ 2010, 2011, 2019 ]
3
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 22, 94, 2805, 3 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 11, 22, 3, 5 ]
5
true
Domain
Tetratricopeptide repeat protein 21A/21B, N-terminal ARM repeat
Tetratricopeptide repeat protein 21A/21B, N-terminal ARM repeat
ARM_TT21_N
3
IPR056834
56,834
Tetratricopeptide repeat protein 21A/21B, C-terminal ARM domain
ARM_TT21_C
Domain
3,191
false
false
This entry represents the C-terminal ARM-repeats domain of Tetratricopeptide repeat protein 21A (TTC21A) and 21B (TTC21B)from human and its homologues. TTC21A/B are intraflagellar transport (IFT)-associated proteins required for spermatogenesis. TTC21A is involved in sperm flagellar formation and intraflagellar transpo...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25063" ]
[ "ARM_TT21_C" ]
[ 3191 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924" ]
6
[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8hmc", "8hmd", "8ruy" ]
9
[ "PUB00089704", "PUB00090860", "PUB00159879" ]
[ "20889716", "21258341", "30929735" ]
[ "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.", "Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice." ]
[ 2010, 2011, 2019 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]
[ 320, 2855, 2, 14 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 11, 13, 3, 3 ]
5
true
Domain
Tetratricopeptide repeat protein 21A/21B, C-terminal ARM domain
Tetratricopeptide repeat protein 21A/21B, C-terminal ARM domain
ARM_TT21_C
6
IPR056835
56,835
Tetratricopeptide repeat protein 21A/21B, fifth ARM repeats domain
ARM_TT21_5th
Domain
2,971
false
false
This is the fifth ARM-repeats domain found towards the C-terminal end of Tetratricopeptide repeat protein 21A (TTC21A) and 21B (TTC21B)from human and its homologues. TTC21A/B are intraflagellar transport (IFT)-associated proteins required for spermatogenesis. TTC21A is involved in sperm flagellar formation and intrafla...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25064" ]
[ "ARM_TT21_5th" ]
[ 2971 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924" ]
6
[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8hmc", "8hmd", "8ruy" ]
9
[ "PUB00089704", "PUB00090860", "PUB00159879" ]
[ "20889716", "21258341", "30929735" ]
[ "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.", "Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice." ]
[ 2010, 2011, 2019 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)", "ecological metagenomes" ]
[ 114, 2854, 1, 2 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 11, 18, 3, 4 ]
5
true
Domain
Tetratricopeptide repeat protein 21A/21B, fifth ARM repeats domain
Tetratricopeptide repeat protein 21A/21B, fifth ARM repeats domain
ARM_TT21_5th
1
IPR056836
56,836
Tetratricopeptide repeat protein 21A/21B, fourth ARM domain
ARM_TT21_4th
Domain
3,189
false
false
This entry represents the fourth ARM-repeats domain found around the middle of Tetratricopeptide repeat protein 21A (TTC21A) and 21B (TTC21B) from human and its homologues. TTC21A/B are intraflagellar transport (IFT)-associated proteins required for spermatogenesis. TTC21A is involved in sperm flagellar formation and i...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25068" ]
[ "ARM_TT21_4th" ]
[ 3189 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924" ]
6
[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8hmc", "8hmd", "8ruy", "9eh1" ]
10
[ "PUB00089704", "PUB00090860", "PUB00159879" ]
[ "20889716", "21258341", "30929735" ]
[ "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.", "Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice." ]
[ 2010, 2011, 2019 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 24, 3165 ]
2
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 11, 1, 18, 7, 6 ]
6
true
Domain
Tetratricopeptide repeat protein 21A/21B, fourth ARM domain
Tetratricopeptide repeat protein 21A/21B, fourth ARM domain
ARM_TT21_4th
3
IPR056838
56,838
IFT122, zinc ribbon domain
Zn_ribbon_IFT122
Domain
2,277
false
false
This zinc ribbon domain is found in the human Intraflagellar transport protein 122 homolog (IFT122) and related animal proteins. IFT122 contains two zinc ribbon domains toward the C-terminal. This one is the first of the pair. Intraflagellar transport protein 122 homolog (IFT122) is one of the core components (together...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25144" ]
[ "Zn_ribbon_IFT122" ]
[ 2277 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-5610787", "R-CEL-5620924", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-XTR-5610787" ]
[ "REACTOME:R-CEL-5610787", "REACTOME:R-CEL-5620924", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924", "REACTOME:R-XTR-5610787" ]
7
[ "8bbe", "8bbf", "8bbg", "8bda", "8fgw", "8fh3", "8ruy" ]
7
[ "PUB00101516", "PUB00155528" ]
[ "29220510", "36462505" ]
[ "Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.", "IFT-A structure reveals carriages for membrane protein transport into cilia." ]
[ 2018, 2022 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2277 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 7, 2, 39, 4, 6 ]
6
true
Domain
IFT122, zinc ribbon domain
IFT122, zinc ribbon domain
Zn_ribbon_IFT122
5
IPR056839
56,839
AHK4/CRE1/WOL, first receiver domain
Receiver_AHK4/CRE1_1st
Domain
2,668
false
false
This entry represents the first receiver domain found in AtHK4 (also known as CRE1 and WOL) from Arabidopsis thaliana, CRE1 from Medicago truncatula ( ) and its homologues from plants such as AtHK2, AtHK3, OsHK5 and OsHK6 [ ]. AtHK4/CRE1 is a cytokinin (CK) receptor. Alternative splicing of AtHK4/CRE1 results in fine-t...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24896" ]
[ "Receiver_CRE1" ]
[ 2668 ]
1
[ "EC" ]
[ "2.7.13.3" ]
[ "EC:2.7.13.3" ]
1
[ "7p8e" ]
1
[ "PUB00159926", "PUB00159988" ]
[ "34630499", "39501563" ]
[ "3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From <i>Arabidopsis thaliana</i> and <i>Medicago truncatula</i>.", "A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis." ]
[ 2021, 2024 ]
2
[ "IPR001789" ]
[]
1
0
1
[ "Bacteria", "Streptophyta" ]
[ 3, 2665 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 14, 11, 58 ]
3
true
Domain
AHK4/CRE1/WOL, first receiver domain
AHK4/CRE1/WOL, first receiver domain
Receiver_AHK4/CRE1_1st
8
IPR056840
56,840
Importin-9, central HEAT repeats
HEAT_IPO9_central
Domain
3,899
false
false
This entry represents the central HEAT repeat domain found in the human Importin-9 and the yeast orthologue Importin subunit beta-5. Importin-9 is a nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin [ , ]. It consists of 20 tandem HEAT repeats [ , ]. This entry ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25018" ]
[ "HEAT_IPO9_c" ]
[ 3899 ]
1
[]
[]
[]
0
[ "6aho", "6n1z", "8f0x", "8f19", "8f1e", "8f7a", "8h5b", "9b31", "9b3f", "9b3i" ]
10
[ "PUB00100785", "PUB00159905" ]
[ "34711951", "30855230" ]
[ "AKIRIN2 controls the nuclear import of proteasomes in vertebrates.", "Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone." ]
[ 2021, 2019 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3899 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...
[ 7, 2, 1, 1, 4, 1, 1, 3, 1, 1, 19 ]
11
true
Domain
Importin-9, central HEAT repeats
Importin-9, central HEAT repeats
HEAT_IPO9_central
8
IPR056842
56,842
tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region
THADA-like_TPR_C
Domain
4,929
false
false
This region of predicted of tetratricopeptide-like repeats is found towards the C-terminal end of human tRNA (32-2'-O)-methyltransferase regulator THADA and its homologues in eukaryotes, including tRNA (32-2'-O)-methyltransferase regulator trm732 from Schizosaccharomyces pombe and Saccharomyces cerevisiae [ , ]. Togeth...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25151" ]
[ "TPR_Trm732_C" ]
[ 4929 ]
1
[ "REACTOME" ]
[ "R-HSA-6782315" ]
[ "REACTOME:R-HSA-6782315" ]
1
[ "8y2o" ]
1
[ "PUB00068806", "PUB00098322", "PUB00155776" ]
[ "22912484", "25404562", "31831667" ]
[ "Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.", "Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes.", "Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-...
[ 2012, 2015, 2019 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4929 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 6, 2, 2, 1, 6, 1, 1, 5, 6, 1, 1, 4 ]
12
true
Domain
tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region
tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region
THADA-like_TPR_C
1
IPR056843
56,843
tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region
THADA-like_TPR
Domain
4,538
false
false
This region of predicted of tetratricopeptide-like repeats is found in human tRNA (32-2'-O)-methyltransferase regulator THADA and its homologues in eukaryotes, including tRNA (32-2'-O)-methyltransferase regulator trm732 from Schizosaccharomyces pombe and Saccharomyces cerevisiae [ , ]. Together with methyltransferase F...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25150" ]
[ "TPR_Trm732" ]
[ 4538 ]
1
[ "REACTOME" ]
[ "R-HSA-6782315" ]
[ "REACTOME:R-HSA-6782315" ]
1
[ "8y2o" ]
1
[ "PUB00068806", "PUB00098322", "PUB00155776" ]
[ "22912484", "25404562", "31831667" ]
[ "Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.", "Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes.", "Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-...
[ 2012, 2015, 2019 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4538 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 5, 2, 2, 1, 7, 1, 1, 5, 6, 1, 1, 5 ]
12
true
Domain
tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region
tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region
THADA-like_TPR
9
IPR056844
56,844
Integrin beta-like protein A-E, N-terminal
SibA-E_N
Domain
143
false
false
This entry represents the N-terminal Ig-like domain (according to structure predictions) of Integrin beta-like proteins A-E (SibA-E) from Dictyostelium discoideum and similar sequences from lower eukaryotes and and bacteria. The SibA (Similar to Integrin Beta) protein is a type I transmembrane protein, and its cytosoli...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24907" ]
[ "SIBA-E_N" ]
[ 143 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155676" ]
[ "16699495" ]
[ "An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]
[ 57, 85, 1 ]
3
[]
[]
0
true
Domain
Integrin beta-like protein A-E, N-terminal
Integrin beta-like protein A-E, N-terminal
SibA-E_N
9
IPR056845
56,845
Zer-1-like, leucine-rich repeats region
LRR_Zer-1
Domain
3,839
false
false
This region of leucine-rich repeats (LRR) is found in Zyg eleven-related protein 1 from Caenorhabditis elegans (Zer-1), human Protein zer-1 homolog and similar eukaryotic proteins. C. elegans Zer-1 functions as a target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1 [ ]. Its human homologue se...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25013" ]
[ "LRR_Zer-1" ]
[ 3839 ]
1
[]
[]
[]
0
[]
0
[ "PUB00050234", "PUB00054473", "PUB00090865", "PUB00095349", "PUB00154335", "PUB00159911", "PUB00159989", "PUB00159990" ]
[ "17889651", "19931471", "17304241", "31273098", "34214466", "21983541", "33093214", "36496439" ]
[ "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.", "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.", "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.", ...
[ 2007, 2009, 2007, 2019, 2021, 2011, 2020, 2022 ]
8
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Metapenaeus joyneri majanivirus", "metagenomes" ]
[ 20, 3814, 2, 3 ]
4
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]
[ 15, 6, 2, 2, 6, 4, 8, 1 ]
8
true
Domain
Zer-1-like, leucine-rich repeats region
Zer-1-like, leucine-rich repeats region
LRR_Zer-1
6
IPR056847
56,847
Integrin beta-like protein A-E, second Ig-like domain
Ig_SibA-E_2nd
Domain
43
false
false
This entry represents the second Ig-like domain (according to structure predictions) of Integrin beta-like proteins A-E (SibA-E) from Dictyostelium discoideum and similar sequences from lower eukaryotes and some bacterial species. The SibA (Similar to Integrin Beta) protein is a type I transmembrane protein, and its cy...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24908" ]
[ "Ig_SIBA-E_2nd" ]
[ 43 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155676" ]
[ "16699495" ]
[ "An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Bacteroidota", "Eukaryota" ]
[ 5, 38 ]
2
[]
[]
0
true
Domain
Integrin beta-like protein A-E, second Ig-like domain
Integrin beta-like protein A-E, second Ig-like domain
Ig_SibA-E_2nd
7
IPR056849
56,849
Integrin beta-like protein A-E, third Ig-like domain
Ig_SibA-E_3rd
Domain
13
false
false
This entry represents the third Ig-like domain (according to structure predictions) of Integrin beta-like proteins A-E (SIBA-E) from Dictyostelium discoideum and similar sequences mainly from lower eukaryotes. The SibA (Similar to Integrin Beta) protein is a type I transmembrane protein, and its cytosolic, transmembran...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24910" ]
[ "Ig_SIBA-E_3rd" ]
[ 13 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155676" ]
[ "16699495" ]
[ "An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Dictyostelium", "Marinobacter algicola DG893" ]
[ 12, 1 ]
2
[]
[]
0
true
Domain
Integrin beta-like protein A-E, third Ig-like domain
Integrin beta-like protein A-E, third Ig-like domain
Ig_SibA-E_3rd
9
IPR056850
56,850
UBP34/UBP24/USP9X/USP9Y-like, ARM repeat region
ARM_UBP34_24_USP9X_Y
Domain
5,926
false
false
This entry represents an ARM-repeats domain found in ubiquitin carboxyl-terminal hydrolases (UCHs), such as human UBP24, UBP34, USP9X and USP9Y and the orthologues from Drosophila. UCHs are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin [ ]. UBP24 regulates cell sur...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25010" ]
[ "ARM_UBP24_USP9X-Y" ]
[ 5926 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "3.4.19.12", "R-DME-2173795", "R-DME-5689880", "R-DME-8866652", "R-DME-9013420", "R-DME-9013424", "R-DME-9033241", "R-HSA-201681", "R-HSA-2173795", "R-HSA-5689880", "R-HSA-8866652", "R-HSA-9013420", "R-HSA-9013424", "R-HSA-9033241", "R-HSA-977225", "R-MMU-201681", "R-MMU-2173795", ...
[ "EC:3.4.19.12", "REACTOME:R-DME-2173795", "REACTOME:R-DME-5689880", "REACTOME:R-DME-8866652", "REACTOME:R-DME-9013420", "REACTOME:R-DME-9013424", "REACTOME:R-DME-9033241", "REACTOME:R-HSA-201681", "REACTOME:R-HSA-2173795", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-8866652", "REACTOME:R-HSA-901...
22
[ "7yxx", "7yxy" ]
2
[ "PUB00069571", "PUB00078669", "PUB00154898" ]
[ "23845989", "23159851", "12895410" ]
[ "Regulation of proteolysis by human deubiquitinating enzymes.", "The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.", "Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome." ]
[ 2014, 2012, 2003 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5926 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 8, 10, 8, 12, 10, 15 ]
6
true
Domain
UBP34/UBP24/USP9X/USP9Y-like, ARM repeat region
UBP34/UBP24/USP9X/USP9Y-like, ARM repeat region
ARM_UBP34_24_USP9X_Y
9
IPR056851
56,851
Integrin beta-like protein A-E, immunoglobulin-like domain
Ig_SibA-E
Domain
43
false
false
This immunoglobulin-like domain (Ig-like) is found in Integrin beta-like protein A-E from Dictyostelium discoideum (SibA-E) and similar sequences mainly found in lower eukaryotes and some bacterial species. The SibA (Similar to Integrin Beta) protein is a type I transmembrane protein, and its cytosolic, transmembrane a...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24619" ]
[ "Ig_SibA" ]
[ 43 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155676" ]
[ "16699495" ]
[ "An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Eukaryota", "Pseudomonadati" ]
[ 39, 4 ]
2
[]
[]
0
true
Domain
Integrin beta-like protein A-E, immunoglobulin-like domain
Integrin beta-like protein A-E, immunoglobulin-like domain
Ig_SibA-E
2
IPR056852
56,852
A-kinase anchor protein 17A/B
AK17A/B
Family
2,891
false
false
This entry includes human AK17A and its orthologue from mouse, AK17B. AK17A was originally reported as the pseudoautosomal or X inactivation escape gene 7 (XE7) and as B-lymphocyte antigen precursor [ ]. It has been suggested that AKAP-17A is an alternative splicing factor and an SR-related splicing protein that intera...
[]
[]
[]
0
[ "PANTHER" ]
[ "PTHR12484" ]
[ "" ]
[ 2891 ]
1
[]
[]
[]
0
[]
0
[ "PUB00083330", "PUB00083331", "PUB00083332" ]
[ "1302606", "16982639", "19840947" ]
[ "Structure and expression of the human pseudoautosomal gene XE7.", "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265.", "Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments." ]
[ 1992, 2006, 2009 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2891 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 2, 1, 3, 3, 3, 6, 7, 5 ]
9
true
Family
A-kinase anchor protein 17A/B
A-kinase anchor protein 17A/B
AK17A/B
3
IPR056854
56,854
Allantoinase, composite domain
ALN_composite
Domain
627
false
false
This entry represents the N-terminal region of the composite domain of Allantoinase (ALN), a protein that catalyses the conversion of allantoin (5-ureidohydantoin) to allantoate by hydrolytic cleavage of the five-member hydantoin ring [ ]. The composite domain of metal-dependent hydrolases has a pseudo-barrel fold that...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24890" ]
[ "ALN_composite" ]
[ 627 ]
1
[]
[]
[]
0
[]
0
[ "PUB00096860" ]
[ "23940254" ]
[ "The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice." ]
[ 2013 ]
1
[]
[]
0
0
null
[ "Bacteria", "Viridiplantae" ]
[ 30, 597 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 5, 2, 9 ]
3
true
Domain
Allantoinase, composite domain
Allantoinase, composite domain
ALN_composite
8
IPR056855
56,855
IQCH-like, ATP-grasp
ATP-grasp_IQCH
Domain
2,132
false
false
This domain is found in human IQ domain-containing protein H (IQCH) and similar eukaryotic and bacterial sequences. IQCH may play a regulatory role in spermatogenesis [ ]. IQCH contains an IQ motif (a short calmodulin-binding motif containing conserved Ile and Gln residues). It also contains a PreATP-grasp domain, an A...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24923" ]
[ "ATP-grasp_IQCH" ]
[ 2132 ]
1
[]
[]
[]
0
[]
0
[ "PUB00088357" ]
[ "15897968" ]
[ "Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 488, 1644 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 16, 2, 4, 6 ]
4
true
Domain
IQCH-like, ATP-grasp
IQCH-like, ATP-grasp
ATP-grasp_IQCH
1
IPR056856
56,856
AP-5 complex subunit zeta-1, C-terminal TPR domain
TPR_AP5Z1_C
Domain
2,064
false
false
This entry represents the C-terminal region of human AP-5 complex subunit zeta-1 (AP5Z1, also known as SPG48), which consists of tetratricopeptide repeats (TPRs). Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to parti...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25154" ]
[ "TPR_AP5Z1_C" ]
[ 2064 ]
1
[]
[]
[]
0
[ "8yab", "8yah" ]
2
[ "PUB00067709", "PUB00067710" ]
[ "22022230", "20613862" ]
[ "The fifth adaptor protein complex.", "A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia." ]
[ 2011, 2010 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2064 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 7, 2, 5, 5, 4, 3, 25 ]
7
true
Domain
AP-5 complex subunit zeta-1, C-terminal TPR domain
AP-5 complex subunit zeta-1, C-terminal TPR domain
TPR_AP5Z1_C
5
IPR056858
56,858
Vacuolar sorting receptor, thioredoxin-like domain
VSR_TRX
Domain
3,975
false
false
This entry represents the thioredoxin (TRX)-like domain found in vacuolar sorting receptors (VSRs) from plants. These proteins are involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles [ , ]. This domain is located in the central region of VSRs, between the N-terminal protease-associated (PA) do...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25011" ]
[ "VSR_TRX" ]
[ 3975 ]
1
[]
[]
[]
0
[ "8r4y", "9b1r" ]
2
[ "PUB00114519", "PUB00159947", "PUB00159991" ]
[ "14657332", "38671060", "10871276" ]
[ "Vacuolar sorting receptor for seed storage proteins in Arabidopsis thaliana.", "Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana.", "The plant vacuolar sorting receptor AtELP is involved in transport of NH(2)-terminal propeptide-containing vacu...
[ 2003, 2024, 2000 ]
3
[]
[]
0
0
null
[ "Bacteria candidate phyla", "Eukaryota", "Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)", "marine sediment metagenome" ]
[ 16, 3957, 1, 1 ]
4
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 39, 28, 48 ]
3
true
Domain
Vacuolar sorting receptor, thioredoxin-like domain
Vacuolar sorting receptor, thioredoxin-like domain
VSR_TRX
3
IPR056861
56,861
Hemicentin-1-like, von Willebrand factor A domain
HMCN1-like_VWA
Domain
7,013
false
false
This domain is found in human Hemicentin-1 (HMCN1), von Willebrand factor A domain-containing protein 7 (VWA7), Protein irg-7 from Caenorhabditis elegans and similar sequences. HMCN1 is involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25106" ]
[ "VWA_4" ]
[ 7013 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057248", "PUB00083205", "PUB00155634", "PUB00158859", "PUB00158860", "PUB00159948", "PUB00160748" ]
[ "12388743", "21215633", "28196094", "29488390", "34504132", "10803853", "11261934" ]
[ "Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.", "A secreted protein promotes cleavage furrow maturation during cytokinesis.", "Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-t...
[ 2002, 2011, 2017, 2018, 2021, 2000, 2001 ]
7
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "ecological metagenomes" ]
[ 1112, 5858, 18, 7, 18 ]
5
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]
[ 9, 17, 11, 7, 2, 6 ]
6
true
Domain
Hemicentin-1-like, von Willebrand factor A domain
Hemicentin-1-like, von Willebrand factor A domain
HMCN1-like_VWA
4
IPR056863
56,863
Laminin/attractin/netrin-like, EGF domain
LMN_ATRN_NET-like_EGF
Domain
33,310
false
false
This entry represents EGF-like domains found in laminin subunits (LMN alpha, beta, gamma), attractin (ATRN), netrins (NET) and related animal proteins. ATRN is involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. It may play a role in melanocor...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24973" ]
[ "EGF_LMN_ATRN" ]
[ 33310 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-DME-373752", "R-HSA-1474228", "R-HSA-163125", "R-HSA-1971475", "R-HSA-2022090", "R-HSA-2022928", "R-HSA-2024096", "R-HSA-216083", "R-HSA-2214320", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-3560783", "R-HSA-3560801", "R-HSA-3656237", "R-HSA-3656253", "R-HSA-373752",...
[ "REACTOME:R-DME-373752", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-163125", "REACTOME:R-HSA-1971475", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-2022928", "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-2214320", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-3000171", "REACTOME:R...
44
[ "1klo", "1npe", "3zyj", "4aqs", "4aqt", "4ove", "4plm", "4pln", "4plo", "4urt", "4wnx", "6fkq", "7ler", "7lrf", "7ndg", "7ne0", "7ne1", "8dmk", "8edk", "8snp", "8tsm", "9az3", "9d77", "9i5a", "9i5b" ]
25
[ "PUB00082152", "PUB00099094", "PUB00099095", "PUB00155414" ]
[ "9736737", "28483977", "15343335", "17261078" ]
[ "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.", "Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.", "Netrin-1 controls colorectal tumorigenesis by...
[ 1998, 2017, 2004, 2007 ]
4
[ "IPR002049" ]
[]
1
0
1
[ "Opisthokonta" ]
[ 33310 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 22, 114, 49, 71, 52, 100 ]
6
true
Domain
Laminin/attractin/netrin-like, EGF domain
Laminin/attractin/netrin-like, EGF domain
LMN_ATRN_NET-like_EGF
4
IPR056864
56,864
Large ribosomal subunit protein bL9m, N-terminal domain
MRP-L9_N
Domain
657
false
false
This domain is found at the N-terminal of human Large ribosomal subunit protein bL9m (MRP-L9) and similar proteins specific to vertebrates. MRP-L9 is a structural component of the large subunit of the ribosome [ , , , ]. It shows two β-sheets connected by a loop [ ]. Ribosomes are the particles that catalyse mRNA-direc...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25131" ]
[ "bL9m_N" ]
[ 657 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]
[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOM...
13
[ "3j7y", "3j9m", "4ce4", "4v19", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08"...
92
[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00089007", "PUB00089008", "PUB00090386", "PUB00154377", "PUB00160049" ]
[ "11297922", "11290319", "11114498", "25278503", "25838379", "28892042", "35177605", "33910005" ]
[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Structure of the large ribosomal subunit from human mitochondria.", "Ribosome. The structure of the human mitochondrial ribosome.", "Structures of the human...
[ 2001, 2001, 2000, 2014, 2015, 2017, 2022, 2021 ]
8
[]
[]
0
0
null
[ "Vertebrata" ]
[ 657 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 8, 4, 9 ]
4
true
Domain
Large ribosomal subunit protein bL9m, N-terminal domain
Large ribosomal subunit protein bL9m, N-terminal domain
MRP-L9_N
5
IPR056865
56,865
Serine/threonine-protein kinase WNK, CCTL2 domain
CCTL2_WNK
Domain
7,408
false
false
This is the CCT-like domain 2 (CCTL2) from animal WNK proteins (WNK1-4), which are serine/threonine-protein kinase components of the WNK-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signalling survival, and proliferation [ , , ]. The exact function of this d...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24889" ]
[ "CCTL2_WNK" ]
[ 7408 ]
1
[ "EC", "REACTOME" ]
[ "2.7.11.1", "R-HSA-2672351" ]
[ "EC:2.7.11.1", "REACTOME:R-HSA-2672351" ]
2
[ "5g3q" ]
1
[ "PUB00131555", "PUB00159885", "PUB00159886" ]
[ "18593598", "34312216", "21733846" ]
[ "WNK2 modulates MEK1 activity through the Rho GTPase pathway.", "CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling.", "WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters." ]
[ 2008, 2022, 2011 ]
3
[]
[]
0
0
null
[ "Eukaryota", "bird metagenome" ]
[ 7407, 1 ]
2
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 103, 3, 11, 15, 25 ]
6
true
Domain
Serine/threonine-protein kinase WNK, CCTL2 domain
Serine/threonine-protein kinase WNK, CCTL2 domain
CCTL2_WNK
4
IPR056866
56,866
WRKY19-like, zinc finger domain
Znf_WRKY19
Domain
6,210
false
false
This entry represents a small zinc finger domain found in the probable WRKY transcription factor 19 from Arabidopsis thaliana (WRKY19) and similar proteins from plants and lower eukaryotes. Structure prediction suggests that this protein may have an array of these domains that wrap around the major groove of DNA. This ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24906" ]
[ "Zf_WRKY19" ]
[ 6210 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota", "viral metagenome" ]
[ 6204, 6 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 26, 33, 42 ]
3
true
Domain
WRKY19-like, zinc finger domain
WRKY19-like, zinc finger domain
Znf_WRKY19
3
IPR056869
56,869
LRRD1, death domain
DD_LRRD1
Domain
262
false
false
This entry represents the C-terminal death domain (DD) found in LRRD1 protein and related proteins from vertebrates. LRRD1 was recently identified as a component of the radial spokes (RS3) in the mammalian motile cilia that along with Sperm-specific RS3 protein STKLD1, interact with EFCAB5 to further stabilise the stru...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24978" ]
[ "Death_Lrrd1" ]
[ 262 ]
1
[]
[]
[]
0
[ "9fqr", "9ijj" ]
2
[ "PUB00159998" ]
[ "39743588" ]
[ "Structural diversity of axonemes across mammalian motile cilia." ]
[ 2025 ]
1
[]
[]
0
0
null
[ "Bilateria" ]
[ 262 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 1, 2 ]
3
true
Domain
LRRD1, death domain
LRRD1, death domain
DD_LRRD1
3
IPR056870
56,870
TTC3/DZIP3/RBM44-like, helical domain
TTC3/DZIP3/RBM44-like_helical
Domain
2,605
false
false
This domain is found in human E3 ubiquitin-protein ligase TTC3, E3 ubiquitin-protein ligase DZIP3 [ ] and similar sequences predominantly found in vertebrates. TTC3 catalyses the formation of 'Lys-48'- polyubiquitin chains and regulates Akt signalling, TGFB1-induced epithelial-mesenchymal transition and myofibroblast d...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24905" ]
[ "TTC3_9th" ]
[ 2605 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-983168", "R-MMU-983168" ]
[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]
2
[]
0
[ "PUB00077706", "PUB00096669", "PUB00138189", "PUB00155891" ]
[ "12538761", "30696809", "24695496", "30203323" ]
[ "hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase.", "TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.", "The DCR protein TTC3 affects differentiation and Golgi compactness in neu...
[ 2003, 2019, 2014, 2019 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2605 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 11, 12, 10, 23 ]
4
true
Domain
TTC3/DZIP3/RBM44-like, helical domain
TTC3/DZIP3/RBM44-like, helical domain
TTC3/DZIP3/RBM44-like_helical
8
IPR056871
56,871
E3 ubiquitin-protein ligase TTC3, winged helix turn helix domain
WH_TTC3
Domain
1,247
false
false
This domain is found in human E3 ubiquitin-protein ligase TTC3, which catalyses the formation of 'Lys-48'-polyubiquitin chains and regulates Akt signalling, TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation, neuronal differentiation and cell proliferation [ , , ]. This domain is predicte...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24812" ]
[ "WHD_TTC3" ]
[ 1247 ]
1
[ "EC", "METACYC" ]
[ "2.3.2.27", "PWY-7511" ]
[ "EC:2.3.2.27", "METACYC:PWY-7511" ]
2
[]
0
[ "PUB00096669", "PUB00138189", "PUB00155891" ]
[ "30696809", "24695496", "30203323" ]
[ "TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.", "The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways.", "Overexpressed TTC3 P...
[ 2019, 2014, 2019 ]
3
[]
[]
0
0
null
[ "Metazoa" ]
[ 1247 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 9, 9, 8, 10 ]
4
true
Domain
E3 ubiquitin-protein ligase TTC3, winged helix turn helix domain
E3 ubiquitin-protein ligase TTC3, winged helix turn helix domain
WH_TTC3
3
IPR056872
56,872
TTC3/DZIP3-like, helical domain
TTC3/DZIP3-like_helical
Domain
2,757
false
false
This domain is found in human E3 ubiquitin-protein ligase TTC3, E3 ubiquitin-protein ligase DZIP3 [ ] and similar sequences predominantly found in vertebrates. TTC3 catalyses the formation of 'Lys-48'- polyubiquitin chains and regulates Akt signalling, TGFB1-induced epithelial-mesenchymal transition and myofibroblast d...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24525" ]
[ "TTC3" ]
[ 2757 ]
1
[ "EC", "METACYC", "REACTOME", "REACTOME" ]
[ "2.3.2.27", "PWY-7511", "R-HSA-983168", "R-MMU-983168" ]
[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]
4
[]
0
[ "PUB00077706", "PUB00096669", "PUB00138189", "PUB00155891" ]
[ "12538761", "30696809", "24695496", "30203323" ]
[ "hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase.", "TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.", "The DCR protein TTC3 affects differentiation and Golgi compactness in neu...
[ 2003, 2019, 2014, 2019 ]
4
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 2757 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 9, 11, 10, 22 ]
5
true
Domain
TTC3/DZIP3-like, helical domain
TTC3/DZIP3-like, helical domain
TTC3/DZIP3-like_helical
6
IPR056874
56,874
PHD-type zinc finger, plants
PHD_dom_pln
Domain
1,556
false
false
This presumed PHD-type zinc finger domain is found in a group of uncharacterised plant proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF25054" ]
[ "PHD_pln" ]
[ 1556 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Embryophyta" ]
[ 1556 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 9, 13, 26 ]
3
true
Domain
PHD-type zinc finger, plants
PHD-type zinc finger, plants
PHD_dom_pln
6
IPR056875
56,875
MCM8/REC, winged helix domain
MCM8/REC_WHD
Domain
2,532
false
false
The domain represented by this entry is located at the C-terminal of MCM8. It adopts a winged helix fold, and it has a DNA binding activity [ ]. This domain is also found in DNA replication licensing factor REC, a distant MCM homologue, which has no, or only a minor, role in DNA repair and recombination in somatic cell...
[]
[]
[]
0
[ "PFAM", "CDD" ]
[ "PF25051", "cd22247" ]
[ "WHD_MCM8", "MCM8_WHD" ]
[ 2519, 2437 ]
2
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "5.6.2.4", "R-BTA-176187", "R-BTA-68689", "R-BTA-68949", "R-BTA-68962", "R-DME-176187", "R-DME-68689", "R-DME-68949", "R-DME-68962", "R-GGA-176187", "R-GGA-68689", "R-GGA-68949", "R-GGA-68962", "R-HSA-113507", "R-HSA-176187", "R-HSA-176974", "R-HSA-68689", "R-HSA-68949", "R-HSA-6...
[ "EC:5.6.2.4", "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68689", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-DME-176187", "REACTOME:R-DME-68689", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-GGA-176187", "REACTOME:R-GGA-68689", "REACTOME:R-GGA-68949", "REACTOME:R...
30
[ "6l0o", "7wi7", "8s91", "8s92", "8s94" ]
5
[ "PUB00093964", "PUB00109388", "PUB00141337", "PUB00148272", "PUB00148273", "PUB00148274", "PUB00148275", "PUB00148276", "PUB00148277", "PUB00148278", "PUB00159999", "PUB00161335" ]
[ "31467087", "26215093", "23401855", "32295713", "12527764", "12771218", "15684404", "16325355", "18072282", "25437880", "14676427", "34043945" ]
[ "Control of homologous recombination by the HROB-MCM8-MCM9 pathway.", "MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.", "The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.", "Crystal structure of the winged-h...
[ 2019, 2015, 2013, 2020, 2003, 2003, 2005, 2006, 2008, 2015, 2003, 2021 ]
12
[]
[]
0
0
null
[ "Eukaryota", "Syntrophomonas wolfei", "mine drainage metagenome" ]
[ 2530, 1, 1 ]
3
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 7, 3, 4, 5, 1, 2, 2, 6 ]
8
true
Domain
MCM8/REC, winged helix domain
MCM8/REC, winged helix domain
MCM8/REC_WHD
9
IPR056876
56,876
Mechanosensitive ion channel protein 2/3, C-terminal
Msl2-3_C
Domain
1,443
false
false
This entry represents the C-terminal domain of Mechanosensitive ion channel proteins 2 and 3 from Arabidopsis and related plant sequences. These channels open in response to stretch forces in the membrane lipid bilayer and control plastid size, shape, and perhaps division during normal plant development by altering ion...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24956" ]
[ "Msl2-3_C" ]
[ 1443 ]
1
[]
[]
[]
0
[]
0
[ "PUB00097794", "PUB00159912" ]
[ "21810996", "16401419" ]
[ "Two mechanosensitive channel homologs influence division ring placement in Arabidopsis chloroplasts.", "MscS-like proteins control plastid size and shape in Arabidopsis thaliana." ]
[ 2011, 2006 ]
2
[]
[]
0
0
null
[ "Eukaryota", "Pseudomonadati" ]
[ 1430, 13 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 10, 3, 6 ]
3
true
Domain
Mechanosensitive ion channel protein 2/3, C-terminal
Mechanosensitive ion channel protein 2/3, C-terminal
Msl2-3_C
3
IPR056877
56,877
Mediator of RNA polymerase II transcription subunit 14, C-terminal domain
Med14_C
Domain
2,028
false
false
This entry represents a domain found in the human Mediator of RNA polymerase II transcription subunit 14 (Med14) and related proteins. This domain located at the C terminus and predicted to adopt a globular α/β structure. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcriptio...
[]
[]
[]
0
[ "PFAM" ]
[ "PF25069" ]
[ "Med14_C" ]
[ 2028 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]
[ "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]
6
[ "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]
14
[ "PUB00111733", "PUB00151584", "PUB00154060" ]
[ "16595664", "33958484", "31402173" ]
[ "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.", "Structures of the human Mediator and Mediator-bound preinitiation complex.", "A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote...
[ 2006, 2021, 2019 ]
3
[]
[]
0
0
null
[ "Metazoa" ]
[ 2028 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 3, 4, 2, 6 ]
5
true
Domain
Mediator of RNA polymerase II transcription subunit 14, C-terminal domain
Mediator of RNA polymerase II transcription subunit 14, C-terminal domain
Med14_C
1