interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR056878 | 56,878 | Mediator of RNA polymerase II transcription subunit 14, RM5 | RM5_Med14 | Domain | 1,877 | false | false | This entry represents a domain found in the human Mediator of RNA polymerase II transcription subunit 14 (Med14) and related proteins. This entry represents repeat RM5. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25067"
] | [
"RM5_Med14"
] | [
1877
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 14 | [
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"16595664",
"33958484",
"31402173"
] | [
"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.",
"Structures of the human Mediator and Mediator-bound preinitiation complex.",
"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote... | [
2006,
2021,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1877
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
2,
6
] | 5 | true | Domain | Mediator of RNA polymerase II transcription subunit 14, RM5 | Mediator of RNA polymerase II transcription subunit 14, RM5 | RM5_Med14 | 5 |
IPR056879 | 56,879 | Mediator of RNA polymerase II transcription subunit 14, RM3 | RM3_Med14 | Domain | 2,079 | false | false | This entry represents a domain found in the human Mediator of RNA polymerase II transcription subunit 14 (Med14) and related animal proteins. This entry represents repeat RM3. Med14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent ge... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25065"
] | [
"RM3_Med14"
] | [
2079
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 14 | [
"PUB00111733",
"PUB00151584",
"PUB00154060"
] | [
"16595664",
"33958484",
"31402173"
] | [
"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.",
"Structures of the human Mediator and Mediator-bound preinitiation complex.",
"A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promote... | [
2006,
2021,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2079
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
2,
2,
6
] | 6 | true | Domain | Mediator of RNA polymerase II transcription subunit 14, RM3 | Mediator of RNA polymerase II transcription subunit 14, RM3 | RM3_Med14 | 3 |
IPR056881 | 56,881 | Meiotically up-regulated gene 62 protein-like, alpha-beta domain | Mug62_dom | Domain | 1,882 | false | false | This domain is found in Meiotically up-regulated gene 62 protein from Schizosaccharomyces pombe (Mug62) and similar proteins predominantly found in fungi, including Homeostatic regulator of DAG [ ]. Mug62 plays a role in meiosis. This domain is often found associated to and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24919"
] | [
"Mug62"
] | [
1882
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160003"
] | [
"35766356"
] | [
"DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
40,
1842
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
3
] | 3 | true | Domain | Meiotically up-regulated gene 62 protein-like, alpha-beta domain | Meiotically up-regulated gene 62 protein-like, alpha-beta domain | Mug62_dom | 4 |
IPR056882 | 56,882 | MOM1, alpha-helical domain | MOM1_dom | Domain | 1,380 | false | false | This domain is found in Helicase protein MOM1 from Arabidopsis thaliana (MOM1) and similar plant proteins. MOM1 is involved in the regulation of transcriptional gene silencing (TGS) independently of changes in DNA methylation [ , , ]. This domain is predicted to have an all-α helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25029"
] | [
"MOM1"
] | [
1380
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160044",
"PUB00160045",
"PUB00160046"
] | [
"17082821",
"22346760",
"27113777"
] | [
"MOM1 mediates DNA-methylation-independent silencing of repetitive sequences in Arabidopsis.",
"Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.",
"The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.... | [
2006,
2012,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1380
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
3,
68
] | 3 | true | Domain | MOM1, alpha-helical domain | MOM1, alpha-helical domain | MOM1_dom | 9 |
IPR056883 | 56,883 | Nephrocystin 3, helical domain | NPHP3_hel | Domain | 1,079 | false | false | This entry represents a mostly helical domain found in nephrocystin-3 (NPHP3) and related proteins from animals. NPHP3 is a protein required for normal ciliary development and function. It inhibits disheveled-1-induced canonical Wnt-signalling activity and may also play a role in the control of non-canonical Wnt signal... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24884"
] | [
"NPHP3_hel"
] | [
1079
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5624138",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-DRE-5624138",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 3 | [] | 0 | [
"PUB00159915"
] | [
"18371931"
] | [
"Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"hydrothermal vent metagenome"
] | [
1076,
2,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
3,
3
] | 4 | true | Domain | Nephrocystin 3, helical domain | Nephrocystin 3, helical domain | NPHP3_hel | 2 |
IPR056884 | 56,884 | Nephrocystin 3-like, N-terminal | NPHP3-like_N | Domain | 74,647 | false | false | This entry represents a P-loop like domain found at the N-terminal of nephrocystin-3 (NPHP3) as well as in the Ankyrin repeat domain-containing protein 50, Ankyrin repeat domain-containing protein SAT10, Vegetative incompatibility protein HET-E-1 and other related eukaryotic and bacterial proteins. This domain belongs ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24883"
] | [
"NPHP3_N"
] | [
74647
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5624138",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-DRE-5624138",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 3 | [] | 0 | [
"PUB00064266",
"PUB00087317",
"PUB00159915",
"PUB00160004"
] | [
"15381417",
"25015739",
"18371931",
"25278552"
] | [
"STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer.",
"Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stac... | [
2004,
2014,
2008,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"metagenomes"
] | [
1159,
73460,
9,
19
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
7,
11,
2,
6,
15,
4
] | 7 | true | Domain | Nephrocystin 3-like, N-terminal | Nephrocystin 3-like, N-terminal | NPHP3-like_N | 1 |
IPR056885 | 56,885 | Nephrocystin-3, TPR-repeats region | TPR_NPHP3 | Domain | 1,128 | false | false | This entry represents a tetratricopeptide repeats (TPR) region found at the nephrocystin-3 (NPHP3) and related proteins from animals. NPHP3 is a protein required for normal ciliary development and function. It inhibits disheveled-1-induced canonical Wnt-signalling activity and may also play a role in the control of non... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24885"
] | [
"TPR_NPHP3"
] | [
1128
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5624138",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-DRE-5624138",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 3 | [] | 0 | [
"PUB00159915"
] | [
"18371931"
] | [
"Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
20,
1108
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
4,
3
] | 4 | true | Domain | Nephrocystin-3, TPR-repeats region | Nephrocystin-3, TPR-repeats region | TPR_NPHP3 | 4 |
IPR056886 | 56,886 | Nephrocystin-3, alpha-beta domain | NPHP3_ab_dom | Domain | 1,130 | false | false | This domain is found in human Nephrocystin-3 (NPHP3) and similar animal proteins. This domain is predicted to show a β-sheet with α-helices at both sides. NPHP3 is a protein required for normal ciliary development and function. It inhibits disheveled-1-induced canonical Wnt-signalling activity and may also play a role ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25022"
] | [
"NPHP3"
] | [
1130
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5624138",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-DRE-5624138",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 3 | [] | 0 | [
"PUB00159914",
"PUB00159915"
] | [
"27481943",
"18371931"
] | [
"Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.",
"Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia."
] | [
2016,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1130
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
4,
3
] | 4 | true | Domain | Nephrocystin-3, alpha-beta domain | Nephrocystin-3, alpha-beta domain | NPHP3_ab_dom | 2 |
IPR056887 | 56,887 | Nesprin-1/2 domain | SYNE1/2_dom | Domain | 3,598 | false | false | This domain is found in human Nesprin-1/2 (SYNE1, SYNE2) and similar sequences from vertebrates. It is found towards the C-terminal end of the protein between spectrin repeats ( ). Its specific function is unknown. SYNE1 is a a multi-isomeric modular protein which forms a linking network between organelles and the acti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25035"
] | [
"SYNE1"
] | [
3598
] | 1 | [
"REACTOME"
] | [
"R-HSA-1221632"
] | [
"REACTOME:R-HSA-1221632"
] | 1 | [] | 0 | [
"PUB00072122",
"PUB00160005"
] | [
"19596800",
"20724637"
] | [
"Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.",
"Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement."
] | [
2009,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
3598
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
23,
14,
17
] | 4 | true | Domain | Nesprin-1/2 domain | Nesprin-1/2 domain | SYNE1/2_dom | 7 |
IPR056888 | 56,888 | NET2A-D/KIP1-like, alpha-helical domain | NET2A-D/KIP1-like_dom | Domain | 1,806 | false | false | This entry represents a domain found in Protein NETWORKED 2A/B/C/D from Arabidopsis thaliana (NET2A/B/C/D), Kinase-interacting protein 1 (KIP1) from Petunia integrifolia and similar plant proteins. This domain is predicted to adopt an all-α configuration. Plant-specific Networked 2 (NET2) family of actin-binding protei... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25014"
] | [
"NET2A"
] | [
1806
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015195",
"PUB00062155",
"PUB00159913"
] | [
"11500547",
"22840520",
"26771248"
] | [
"Isolation and characterization of kinase interacting protein 1, a pollen protein that interacts with the kinase domain of PRK1, a receptor-like kinase of petunia.",
"A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants.",
"α/β coiled coils."
] | [
2001,
2012,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Eukaryota",
"Halorubrum"
] | [
2,
1799,
5
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
21,
12,
25
] | 3 | true | Domain | NET2A-D/KIP1-like, alpha-helical domain | NET2A-D/KIP1-like, alpha-helical domain | NET2A-D/KIP1-like_dom | 8 |
IPR056890 | 56,890 | ATP-dependent RNA helicase DHX29-like, UBA domain | UBA_DHX29-like | Domain | 2,382 | false | false | This predicted UBA domain is found at the N-terminal of human ATP-dependent RNA helicase DHX29, which is involved in translation initiation. This domain is also found in DExH-box ATP-dependent RNA helicase DExH4 and 7 from Arabidopsis. ATP-dependent RNA helicase DHX29 is a DExH-box protein involved in eukaryotic transl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24899"
] | [
"UBA_DHX29"
] | [
2382
] | 1 | [
"EC"
] | [
"3.6.4.13"
] | [
"EC:3.6.4.13"
] | 1 | [
"9cpa"
] | 1 | [
"PUB00084240",
"PUB00084241"
] | [
"19109895",
"23706745"
] | [
"Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.",
"Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29."
] | [
2008,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2382
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
1,
2,
2,
3,
4,
16
] | 7 | true | Domain | ATP-dependent RNA helicase DHX29-like, UBA domain | ATP-dependent RNA helicase DHX29-like, UBA domain | UBA_DHX29-like | 8 |
IPR056891 | 56,891 | NEW1, helical bundle domain | NEW1_HB | Domain | 145 | false | false | This is the helical bundle (HB) domain found in the [NU+] prion formation protein 1 (NEW1) from S. cerevisiae, a translation termination and ribosome biogenesis factor. NEW1 is an ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24988"
] | [
"NEW1_HB"
] | [
145
] | 1 | [
"REACTOME"
] | [
"R-SCE-382556"
] | [
"REACTOME:R-SCE-382556"
] | 1 | [
"6s47"
] | 1 | [
"PUB00070106",
"PUB00159904"
] | [
"11511346",
"31299085"
] | [
"Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.",
"A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling."
] | [
2001,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
145
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | NEW1, helical bundle domain | NEW1, helical bundle domain | NEW1_HB | 1 |
IPR056892 | 56,892 | AtTam37, zinc finger domain | Zf-AtTam37 | Domain | 531 | false | false | This domain is found in the AtTam37 (also known as Anu7, ) from Arabidopsis thaliana and related proteins. AtTam37 is an essential component of the chloroplast import motor. It serves as a molecular chaperone within the AtYcf2-FtsHi complex [ , ]. The domain represented by this entry contains four highly conserved pair... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25112"
] | [
"zf-AtTam37"
] | [
531
] | 1 | [] | [] | [] | 0 | [
"8xku",
"8xkv"
] | 2 | [
"PUB00159880",
"PUB00160006"
] | [
"39197452",
"28008672"
] | [
"Structural insights into the chloroplast protein import in land plants.",
"The ANGULATA7 gene encodes a DnaJ-like zinc finger-domain protein involved in chloroplast function and leaf development in Arabidopsis."
] | [
2024,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
531
] | 1 | [
"Arabidopsis thaliana"
] | [
11
] | 1 | true | Domain | AtTam37, zinc finger domain | AtTam37, zinc finger domain | Zf-AtTam37 | 3 |
IPR056893 | 56,893 | Nbr1-like, C-terminal UBA domain | UBA_Nbr1_C | Domain | 2,223 | false | false | This UBA domain is found at the C-terminal end of human Next to BRCA1 gene 1 protein (Nbr1) and similar eukaryotic proteins, including JOKA2 from Solanum tuberosum. Nbr1 (next to BRCA1) is an ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24932"
] | [
"UBA_NBR1_C"
] | [
2223
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9664873",
"R-MMU-9664873",
"R-RNO-9664873"
] | [
"REACTOME:R-HSA-9664873",
"REACTOME:R-MMU-9664873",
"REACTOME:R-RNO-9664873"
] | 3 | [
"2cp8",
"2mgw",
"2mj5"
] | 3 | [
"PUB00134172",
"PUB00154475",
"PUB00154476",
"PUB00159943"
] | [
"22654911",
"26765567",
"29932422",
"24692539"
] | [
"MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network.",
"An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.",
"Host autophagy machinery is diverted to the pathogen interface to mediate focal defense... | [
2012,
2016,
2018,
2014
] | 4 | [
"IPR015940"
] | [] | 1 | 0 | 1 | [
"Acetobacter sacchari",
"Eukaryota"
] | [
1,
2222
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
6,
3,
7,
7,
8,
12
] | 7 | true | Domain | Nbr1-like, C-terminal UBA domain | Nbr1-like, C-terminal UBA domain | UBA_Nbr1_C | 8 |
IPR056894 | 56,894 | AtTam38 | AtTam38 | Family | 476 | false | false | This entry represents the AtTam38 protein from Arabidopsis thaliana ( ) and related plant proteins. AtTam38 is a component of the AtYcf2-FtsHi complex. AtTam38 serves as an anchor of the stromal motor module to the IEM (inner envelope membrane of the chloroplast) [ ]. It plays a key role in AtYcf2-FtsHi assembly and ma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25114"
] | [
"AtTam38"
] | [
476
] | 1 | [] | [] | [] | 0 | [
"8xku",
"8xkv"
] | 2 | [
"PUB00159880"
] | [
"39197452"
] | [
"Structural insights into the chloroplast protein import in land plants."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
476
] | 1 | [
"Arabidopsis thaliana"
] | [
5
] | 1 | true | Family | AtTam38 | AtTam38 | AtTam38 | 5 |
IPR056895 | 56,895 | AtTam9 | AtTam9 | Family | 388 | false | false | This entry represents the AtTam9 protein from Arabidopsis thaliana ( ) and related plant proteins. AtTam9 is a component of the AtYcf2-FtsHi complex. AtTam9 is a small soluble protein which mainly interacts with the NTD of FtsHi5, another component of the AtYcf2-FtsHi complex, and likely contributes to the local assemb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25111"
] | [
"AtTam9"
] | [
388
] | 1 | [] | [] | [] | 0 | [
"8xku",
"8xkv"
] | 2 | [
"PUB00159880"
] | [
"39197452"
] | [
"Structural insights into the chloroplast protein import in land plants."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
388
] | 1 | [
"Arabidopsis thaliana"
] | [
3
] | 1 | true | Family | AtTam9 | AtTam9 | AtTam9 | 7 |
IPR056896 | 56,896 | Nonribosomal peptide synthetase sidD, N-terminal | SIDD_N | Domain | 512 | false | false | This entry represents the N-terminal domain of SIDD (Nonribosomal peptide synthetase sidD) from Aspergillus fumigatus and related fungal sequences. SIDD is part of the siderophore biosynthetic pathway [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24895"
] | [
"SIDD_N"
] | [
512
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089635"
] | [
"17845073"
] | [
"Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
512
] | 1 | [] | [] | 0 | true | Domain | Nonribosomal peptide synthetase sidD, N-terminal | Nonribosomal peptide synthetase sidD, N-terminal | SIDD_N | 1 |
IPR056897 | 56,897 | NUP210, fourth Ig-like domain | Ig_NUP210_4th | Domain | 2,157 | false | false | This is the fourth Ig-like domain of NUP210 and its homologues. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobulin-like (Ig-like) domains and forms a ring around the NPC within the NE lumen [ ]. There are... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24991"
] | [
"Ig_NUP210_4th"
] | [
2157
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 58 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2157
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
4,
7
] | 5 | true | Domain | NUP210, fourth Ig-like domain | NUP210, fourth Ig-like domain | Ig_NUP210_4th | 2 |
IPR056898 | 56,898 | NUP210, Ig-like domain 6 | Ig_NUP210_6th | Domain | 2,087 | false | false | This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and similar animal proteins. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobulin-like (Ig-like) domains and forms a ring around... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24935"
] | [
"Ig_NUP210_6th"
] | [
2087
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k"
] | 2 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2087
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
4,
6
] | 5 | true | Domain | NUP210, Ig-like domain 6 | NUP210, Ig-like domain 6 | Ig_NUP210_6th | 1 |
IPR056899 | 56,899 | NUP210, Ig-like domain 9 | Ig_NUP210_9th | Domain | 2,129 | false | false | This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and similar animal proteins. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobulin-like (Ig-like) domains and forms a ring around... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24902"
] | [
"Ig_NUP210_9th"
] | [
2129
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 69 | [
"7r5j",
"7r5k",
"9hcj"
] | 3 | [
"PUB00154131"
] | [
"35679397"
] | [
"AI-based structure prediction empowers integrative structural analysis of human nuclear pores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2129
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3,
5,
5
] | 6 | true | Domain | NUP210, Ig-like domain 9 | NUP210, Ig-like domain 9 | Ig_NUP210_9th | 9 |
IPR056900 | 56,900 | COBRA, C-terminal domain | COB_C | Domain | 6,004 | false | false | This entry represents a domain found C-terminal in the COBRA family of proteins from Arabidopsis thaliana and related plant sequences. COBRA family members are all extracellular glycosyl-phosphatidyl inositol-anchored proteins (GPI-linked) [ ]. COBRA is involved in determining the orientation of cell expansion, probabl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25079"
] | [
"COB_C"
] | [
6004
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044935",
"PUB00160070"
] | [
"12376623",
"11331607"
] | [
"The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion.",
"COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis."
] | [
2002,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
6004
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
42,
25,
45
] | 3 | true | Domain | COBRA, C-terminal domain | COBRA, C-terminal domain | COB_C | 2 |
IPR056901 | 56,901 | CC142, N-terminal | CC142_N | Domain | 292 | false | false | This entry represents the N-terminal coiled-coils of CC142, a protein whose function is still unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25081"
] | [
"CC142_N"
] | [
292
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
292
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Domain | CC142, N-terminal | CC142, N-terminal | CC142_N | 8 |
IPR056902 | 56,902 | YvbJ-like, NTF2-like domain | NTF2_YvbJ | Domain | 450 | false | false | This domain is found in Uncharacterized membrane protein YvbJ from Bacillus subtilis and related proteins found in firmicutes. YvbJ is thought to contain a pair of NTF2-like domains toward the C terminus. This domain is the first in the pair. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25155"
] | [
"NTF2_YvbJ"
] | [
450
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
450
] | 1 | [] | [] | 0 | true | Domain | YvbJ-like, NTF2-like domain | YvbJ-like, NTF2-like domain | NTF2_YvbJ | 2 |
IPR056903 | 56,903 | PA4575-like | PA4575-like | Family | 796 | false | false | This entry represents a family of proteins that includes the Pseudomonas aeruginosa protein PA4575 ( ). The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24876"
] | [
"PA4575"
] | [
796
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Durusdinium trenchii",
"Gammaproteobacteria",
"hydrothermal vent metagenome"
] | [
1,
794,
1
] | 3 | [] | [] | 0 | true | Family | PA4575-like | PA4575-like | PA4575-like | 6 |
IPR056904 | 56,904 | YMR265C-like, C-terminal | YMR265C_C | Domain | 42 | false | false | This is the presumed C-terminal domain of the uncharacterised yeast protein YMR265C, which has a HAD domain ( ) at the N-terminal, found in Swiss Army Knife RNA repair proteins. The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25108"
] | [
"YMR265C_C"
] | [
42
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
42
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | YMR265C-like, C-terminal | YMR265C-like, C-terminal | YMR265C_C | 8 |
IPR056905 | 56,905 | YfjL-like, C-terminal domain | YfjL_C | Domain | 167 | false | false | This entry represents the C-terminal domain of the uncharacterised protein YfjL from Bacillus subtilis and similar sequences from firmicutes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24911"
] | [
"YfjL_C"
] | [
167
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"bioreactor metagenome"
] | [
164,
3
] | 2 | [] | [] | 0 | true | Domain | YfjL-like, C-terminal domain | YfjL-like, C-terminal domain | YfjL_C | 7 |
IPR056906 | 56,906 | Replication-associated protein ORF2/G2P domain | ORF2/G2P_dom | Domain | 3,397 | false | false | This entry represents a domain found in a group of Replication-associated proteins including ORF2 from Spiroplasma virus 4 (SpV4) and G2P from phages such as Xanthomonas phage phiLf and Bdellovibrio phage phiMH2K. These proteins play an essential role in viral DNA replication; they bind the origin of replication and cl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23343"
] | [
"REP_ORF2-G2P"
] | [
3397
] | 1 | [
"EC",
"EC"
] | [
"3.1.21.-",
"6.5.1.1"
] | [
"EC:3.1.21.-",
"EC:6.5.1.1"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid pVT736-1",
"Viruses",
"unclassified sequences"
] | [
83,
2098,
33,
1,
844,
338
] | 6 | [] | [] | 0 | true | Domain | Replication-associated protein ORF2/G2P domain | Replication-associated protein ORF2/G2P domain | ORF2/G2P_dom | 2 |
IPR056907 | 56,907 | U3 small nucleolar RNA-associated protein 6 homolog, C-terminal | UTP6_C | Domain | 2,639 | false | false | U3 small nucleolar RNA-associated protein 6 homolog (UTP6) is a component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [ ]. These proteins consist of TPRs; this entry represents the C-terminal region of UTP6 and similar sequences predominantly found in an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24892"
] | [
"UTP6_C"
] | [
2639
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 4 | [
"7mq8",
"7mq9",
"7mqa"
] | 3 | [
"PUB00008496"
] | [
"12068309"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2639
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
3,
6,
5,
3,
4,
4,
3
] | 8 | true | Domain | U3 small nucleolar RNA-associated protein 6 homolog, C-terminal | U3 small nucleolar RNA-associated protein 6 homolog, C-terminal | UTP6_C | 3 |
IPR056909 | 56,909 | Phage SU10 portal protein | SU10_portal | Family | 1,108 | false | false | This entry represents the portal protein of Escherichia coli phage SU10 and related protein from phages and prophages. The portal protein, encoded by gp6, forms a dodecameric complex that replaces a pentamer of capsid proteins at one vertex of the prolate SU10 capsid ( ) [ ]. The portal complex enables packaging of the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23899"
] | [
"SU10_portal"
] | [
1108
] | 1 | [] | [] | [] | 0 | [
"7sxk",
"7sya",
"7sz4",
"7sz6",
"7z44",
"7z4a",
"7z4b",
"7z4f",
"8zkk",
"8zkm",
"9bgm",
"9d80",
"9d83",
"9k09",
"9k2v",
"9lbz",
"9lc1",
"9nwm"
] | 18 | [
"PUB00153713",
"PUB00160007",
"PUB00160008"
] | [
"36153309",
"35278476",
"39353939"
] | [
"Tail proteins of phage SU10 reorganize into the nozzle for genome delivery.",
"Cryo-EM Structure of a Kinetically Trapped Dodecameric Portal Protein from the Pseudomonas-phage PaP3.",
"Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor."
] | [
2022,
2022,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
3,
535,
8,
353,
209
] | 5 | [] | [] | 0 | true | Family | Phage SU10 portal protein | Phage SU10 portal protein | SU10_portal | 6 |
IPR056910 | 56,910 | Tricalbin-1-3-like, C2 domain | TCB1-3_C2 | Domain | 2,022 | false | false | This entry represents the C2 domain found in Tricalbin-1-3 from Saccharomyces cerevisiae (TCB1-3) and similar fungal proteins. TCB1 may play a role in membrane trafficking [ , ]. This domain is predicted to form an eight-stranded β-sandwich. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24920"
] | [
"C2_TCB1"
] | [
2022
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074935",
"PUB00074939"
] | [
"15049706",
"15141306"
] | [
"The tricalbin C2 domains: lipid-binding properties of a novel, synaptotagmin-like yeast protein family.",
"Characterization of the yeast tricalbins: membrane-bound multi-C2-domain proteins that form complexes involved in membrane trafficking."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2022
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
3,
2
] | 3 | true | Domain | Tricalbin-1-3-like, C2 domain | Tricalbin-1-3-like, C2 domain | TCB1-3_C2 | 1 |
IPR056911 | 56,911 | DNA-binding phage zinc finger domain, putative | Phage_Znf_bind_put | Domain | 1,766 | false | false | This entry represents a large family of zinc binding domains that are found in both phage and bacterial proteins. The phage domains tend to be single domain proteins. The bacterial domains are often found in multidomain proteins. Structure predictions suggest this domain may bind to dsDNA. In about quarter of the prote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24623"
] | [
"Phage_zn_bind_8"
] | [
1766
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"Viruses",
"Zophobas morio",
"ecological metagenomes"
] | [
1291,
15,
452,
1,
7
] | 5 | [] | [] | 0 | true | Domain | DNA-binding phage zinc finger domain, putative | DNA-binding phage zinc finger domain, putative | Phage_Znf_bind_put | 5 |
IPR056912 | 56,912 | Phage JBD30-like tail terminator protein-like | Phage_JBD30_tail_term-like | Family | 1,580 | false | false | This entry represents a family of phage tail terminator proteins related to the Pseudomonas aeruginosa phage JBD30 tail terminator protein [ ]. These proteins form a hexameric ring at the top of the phage tail tube in the neck of the phage ( ). This family also includes proteobacterial prophages. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23840"
] | [
"Phage_tail_terminator"
] | [
1580
] | 1 | [] | [] | [] | 0 | [
"8rk9",
"8rqe"
] | 2 | [
"PUB00160009"
] | [
"39143239"
] | [
"Structure and replication of Pseudomonas aeruginosa phage JBD30."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1518,
2,
51,
9
] | 4 | [] | [] | 0 | true | Family | Phage JBD30-like tail terminator protein-like | Phage JBD30-like tail terminator protein-like | Phage_JBD30_tail_term-like | 3 |
IPR056913 | 56,913 | TRAPPC10/Trs130, N-terminal | TRAPPC10/Trs130_N | Domain | 4,607 | false | false | This domain is found at the N-terminal end of human Trafficking protein particle complex subunit 10 (TRAPPC10), yeast Trafficking protein particle complex II-specific subunit 130 (Trs130) and similar eukaryotic proteins. This domain is predicted to adopt an α-β configuration. The trafficking protein particle complex TR... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23036"
] | [
"TRAPPC10_1st"
] | [
4607
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-204005",
"R-DDI-8876198",
"R-DME-204005",
"R-DME-8876198",
"R-HSA-204005",
"R-HSA-8876198",
"R-MMU-204005",
"R-MMU-8876198",
"R-SCE-204005",
"R-SCE-8876198",
"R-SPO-204005",
"R-SPO-8876198"
] | [
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-204005",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU-8876198",
"REACTOME:R-SCE-204005",
"REACTOME:R-SCE-8876198",
"REACTOME:R-SPO-204005",
"REACTOME:R-SP... | 12 | [
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7u05",
"7u06"
] | 9 | [
"PUB00055557",
"PUB00078813",
"PUB00098094",
"PUB00153720"
] | [
"11239471",
"20972447",
"23078654",
"35080977"
] | [
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"Molecular architecture of the TRAPPII complex and implications for vesicle tethering.",
"Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.",
"Structural basis for assembly of TRAPPII complex a... | [
2001,
2010,
2013,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces actuosus"
] | [
4606,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
2,
1,
1,
2,
2,
1,
2,
4,
1,
1,
8
] | 12 | true | Domain | TRAPPC10/Trs130, N-terminal | TRAPPC10/Trs130, N-terminal | TRAPPC10/Trs130_N | 2 |
IPR056914 | 56,914 | XM1 gp53 minor capsid protein-like | Gp53-like | Family | 1,324 | false | false | This entry represents a family of phage and bacterial prophage proteins, including from Myoviridae Phage XM1 (gp53 minor capsid protein). These proteins form a trimeric arrangement which stabilises the phage capsid ( ) [ ]. They adopt a structure which is known as a β-tulip fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23982"
] | [
"XM1_gp53_minor_capsid"
] | [
1324
] | 1 | [] | [] | [] | 0 | [
"7kmx"
] | 1 | [
"PUB00160010"
] | [
"37632015"
] | [
"Structure of <i>Vibrio</i> Phage XM1, a Simple Contractile DNA Injection Machine."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Endopterygota",
"Methanolobus",
"Viruses",
"metagenomes"
] | [
1162,
3,
6,
150,
3
] | 5 | [] | [] | 0 | true | Family | XM1 gp53 minor capsid protein-like | XM1 gp53 minor capsid protein-like | Gp53-like | 2 |
IPR056915 | 56,915 | Trs130, second Ig-like domain | Ig_TR130_2nd | Domain | 57 | false | false | This domain is found in the yeast Trafficking protein particle complex II-specific subunit 130 (TR130) and related proteins from Saccharomycetes. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. This protein contains four Ig-like domains ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24966"
] | [
"Ig_TR130_2nd"
] | [
57
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-204005",
"R-SCE-8876198"
] | [
"REACTOME:R-SCE-204005",
"REACTOME:R-SCE-8876198"
] | 2 | [
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7u05",
"7u06"
] | 9 | [
"PUB00055557",
"PUB00078813",
"PUB00098094",
"PUB00153720"
] | [
"11239471",
"20972447",
"23078654",
"35080977"
] | [
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"Molecular architecture of the TRAPPII complex and implications for vesicle tethering.",
"Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.",
"Structural basis for assembly of TRAPPII complex a... | [
2001,
2010,
2013,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
57
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Trs130, second Ig-like domain | Trs130, second Ig-like domain | Ig_TR130_2nd | 3 |
IPR056916 | 56,916 | Trs130, NTS domain | NTS_TR130 | Domain | 985 | false | false | This domain is found in the yeast Trafficking protein particle complex II-specific subunit 130 (TR130) and related proteins from ascomycetes. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. This protein contains an N-terminal α-solenoid ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24967"
] | [
"NTS_TR130"
] | [
985
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-204005",
"R-SCE-8876198"
] | [
"REACTOME:R-SCE-204005",
"REACTOME:R-SCE-8876198"
] | 2 | [
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7u05",
"7u06"
] | 9 | [
"PUB00055557",
"PUB00078813",
"PUB00098094",
"PUB00153720"
] | [
"11239471",
"20972447",
"23078654",
"35080977"
] | [
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"Molecular architecture of the TRAPPII complex and implications for vesicle tethering.",
"Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.",
"Structural basis for assembly of TRAPPII complex a... | [
2001,
2010,
2013,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
985
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Trs130, NTS domain | Trs130, NTS domain | NTS_TR130 | 6 |
IPR056918 | 56,918 | Octameric membrane protein | 8xMP | Family | 1,053 | false | false | This entry represents uncharacterised proteins found in bacteria. They are predicted as integral membrane proteins composed of three integral membrane α-helices. Structure prediction suggests that these proteins form an octameric complex ( ipTM = 0.81 pTM = 0.82). This complex contains a central pore. The predicted com... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24838"
] | [
"8xMP"
] | [
1053
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Myoviridae sp. ctoNH1",
"Rotaria magnacalcarata",
"metagenomes"
] | [
38,
997,
1,
1,
16
] | 5 | [] | [] | 0 | true | Family | Octameric membrane protein | Octameric membrane protein | 8xMP | 8 |
IPR056919 | 56,919 | Phage tail assembly chaperone 18 | Phage_TAC_18 | Family | 614 | false | false | This entry represents a putative phage tail assembly chaperone protein protein family found primarily in viruses that infect bacteria. Members are typically around 100 amino acids in length. Tail assembly chaperones are known to assist in forming and attaching phage tails. This entry is found in caudoviruses of several... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23812"
] | [
"Phage_TAC_18"
] | [
614
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
370,
240,
4
] | 3 | [] | [] | 0 | true | Family | Phage tail assembly chaperone 18 | Phage tail assembly chaperone 18 | Phage_TAC_18 | 6 |
IPR056920 | 56,920 | PRTase-CE | PRTase-CE | Domain | 1,145 | false | false | This entry represents PRTase-like domain found in experimentally uncharacterised bacterial proteins. It is predicted to act as an effector in multiple antiviral immunity systems by targeting nucleotides [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24390"
] | [
"PRTase-CE"
] | [
1145
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctvNP11",
"metagenomes"
] | [
9,
1090,
5,
1,
40
] | 5 | [] | [] | 0 | true | Domain | PRTase-CE | PRTase-CE | PRTase-CE | 7 |
IPR056921 | 56,921 | TARBP1 domain | TARBP1_dom | Domain | 843 | false | false | This domain is found in the human probable methyltransferase TARBP1 and similar animal proteins. TARBP1 methylates RNA molecules such as tRNAs [ ]. This domain is often found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25050"
] | [
"TARBP1"
] | [
843
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043301"
] | [
"18412263"
] | [
"Crystal structure of the methyltransferase domain of human TARBP1."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
843
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
1,
3
] | 4 | true | Domain | TARBP1 domain | TARBP1 domain | TARBP1_dom | 1 |
IPR056922 | 56,922 | SUPPRESSOR-OF-WHITE-APRICOT-like, C-terminal | SWAP1_C | Domain | 688 | false | false | This domain is found at the C-terminal end of SUPPRESSOR-OF -WHITE-APRICOT from Arabidopsis thaliana (SWAP1), a member of the SWAP1-SFPS-RRC1 splicing factor complex that modulates photomorphogenesis by regulating the gene expression and pre-messenger RNA alternative splicing of a large number of genes, including those... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25123"
] | [
"SWAP1_C"
] | [
688
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155472"
] | [
"36282917"
] | [
"SWAP1-SFPS-RRC1 splicing factor complex modulates pre-mRNA splicing to promote photomorphogenesis in <i>Arabidopsis</i>."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
688
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
4,
5
] | 3 | true | Domain | SUPPRESSOR-OF-WHITE-APRICOT-like, C-terminal | SUPPRESSOR-OF-WHITE-APRICOT-like, C-terminal | SWAP1_C | 8 |
IPR056923 | 56,923 | Minor tail protein gp31, C-terminal | Minor_tail_gp31_C | Domain | 887 | false | false | This small region is found at the C terminus of a Minor tail protein gp31 from mycobacteriophages such as D29, Bxb1, L5 and related proteins from tailed bacteriophages and some bacterial prophages. According to structure predictions these proteins form homotrimers. Presumably this domain mediates interaction with eithe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24243"
] | [
"Phage_tail_C"
] | [
887
] | 1 | [] | [] | [] | 0 | [
"9d93"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobrevibacter",
"Tribonema minus",
"Viruses",
"metagenomes"
] | [
176,
5,
1,
696,
9
] | 5 | [] | [] | 0 | true | Domain | Minor tail protein gp31, C-terminal | Minor tail protein gp31, C-terminal | Minor_tail_gp31_C | 6 |
IPR056924 | 56,924 | Tf2-1-like, SH3-like domain | SH3_Tf2-1 | Domain | 66,823 | false | false | This domain is found towards the C-terminal end of Transposon Tf2-1 polyprotein from Schizosaccharomyces pombe (Tf2-1), a retrotransposon that belong to the gypsy-like elements. Members of this group are found in eukaryotes. The Tf2-1 polyprotein encodes several functional domains that act in concert during retrotransp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24626"
] | [
"SH3_Tf2-1"
] | [
66823
] | 1 | [
"EC",
"EC",
"EC"
] | [
"2.7.7.49",
"2.7.7.7",
"3.4.23.-"
] | [
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.4.23.-"
] | 3 | [
"7q5b"
] | 1 | [
"PUB00163234",
"PUB00163235",
"PUB00163236",
"PUB00163237"
] | [
"11003674",
"12692246",
"8223497",
"9774697"
] | [
"Nuclear import of the retrotransposon Tf1 is governed by a nuclear localization signal that possesses a unique requirement for the FXFG nuclear pore factor Nup124p.",
"A long terminal repeat-containing retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like partic... | [
2000,
2003,
1993,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cladosporium fulvum T-1 virus",
"Eukaryota"
] | [
15,
1,
66807
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
46,
5,
845,
2,
13,
10
] | 6 | true | Domain | Tf2-1-like, SH3-like domain | Tf2-1-like, SH3-like domain | SH3_Tf2-1 | 8 |
IPR056925 | 56,925 | ParE-like toxin domain | ParE-like | Domain | 1,622 | false | false | This entry represents a ParE-like domain found in bacteria, bacteriophages and bacterial prophages. It is predominantly present in RelE/HigB/ParE toxins and some DNA-binding proteins such as transposases and endonucleases. The ParE-like domain is located at the C-terminal in proteins with an N-terminal zinc-binding dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24732"
] | [
"ParE_like"
] | [
1622
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015218"
] | [
"14659018"
] | [
"New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
1586,
27,
2,
7
] | 4 | [] | [] | 0 | true | Domain | ParE-like toxin domain | ParE-like toxin domain | ParE-like | 8 |
IPR056926 | 56,926 | Fluoroquinolones export permease | FLQE3_permease | Family | 636 | false | false | This entry represents the Fluoroquinolones export permease protein family, which is involved in the export of fluoroquinolones as part of an ABC transporter complex. This family is likely responsible for the translocation of substrates across the membrane and confers resistance to various fluoroquinolones, including ci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24686"
] | [
"FLQE3_permease"
] | [
636
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160012"
] | [
"15273144"
] | [
"Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
581,
46,
9
] | 3 | [] | [] | 0 | true | Family | Fluoroquinolones export permease | Fluoroquinolones export permease | FLQE3_permease | 2 |
IPR056927 | 56,927 | Phage tail assembly chaperone protein | Phage_TAC | Family | 464 | false | false | This family represents phage tail assembly chaperone proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23781"
] | [
"Phage_TAC_16"
] | [
464
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Caudoviricetes"
] | [
48,
416
] | 2 | [] | [] | 0 | true | Family | Phage tail assembly chaperone protein | Phage tail assembly chaperone protein | Phage_TAC | 6 |
IPR056929 | 56,929 | RING zinc finger-like domain | Znf_RING-like | Domain | 940 | false | false | This domain is found in uncharacterised fungal proteins. It is predicted to fold into a structure with significant similarity to RING/U-box domains. It contains four highly conserved pairs of cysteine residues. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25080"
] | [
"zf_RING-like"
] | [
940
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
940
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | RING zinc finger-like domain | RING zinc finger-like domain | Znf_RING-like | 8 |
IPR056930 | 56,930 | Transposon Tf2-1-like, C-terminal | Tf2-1-like_C | Domain | 14 | false | false | This is the C-terminal region of Transposon Tf2-1 polyprotein from Schizosaccharomyces pombe (Tf2-1) and similar fungal sequences. This region is predicted to adopt an all-α structure. Members of this group are specific to Schizosaccharomyces. The Tf2-1 polyprotein encodes several functional domains that act in concert... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24614"
] | [
"Tf2-1_C"
] | [
14
] | 1 | [
"EC",
"EC",
"EC"
] | [
"2.7.7.49",
"2.7.7.7",
"3.4.23.-"
] | [
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.4.23.-"
] | 3 | [] | 0 | [
"PUB00163234",
"PUB00163235",
"PUB00163236",
"PUB00163237"
] | [
"11003674",
"12692246",
"8223497",
"9774697"
] | [
"Nuclear import of the retrotransposon Tf1 is governed by a nuclear localization signal that possesses a unique requirement for the FXFG nuclear pore factor Nup124p.",
"A long terminal repeat-containing retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like partic... | [
2000,
2003,
1993,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Schizosaccharomyces pombe"
] | [
14
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
13
] | 1 | true | Domain | Transposon Tf2-1-like, C-terminal | Transposon Tf2-1-like, C-terminal | Tf2-1-like_C | 1 |
IPR056933 | 56,933 | Separase-like, TPR repeats region | TPR_ESP1 | Domain | 746 | false | false | This region of tetratricopeptide (TPR)-like repeats is found in Separase from Arabidopsis thaliana (ESP1) and similar plant proteins. ESP1 is essential for embryo and endosperm development and may play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25110"
] | [
"TPR_ESP1"
] | [
746
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160013",
"PUB00160014",
"PUB00160015"
] | [
"19592426",
"20150278",
"21559383"
] | [
"Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis.",
"A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability.",
"The radially swollen 4 separase mutation of Arabidopsis thaliana blo... | [
2009,
2010,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
746
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
1,
8
] | 3 | true | Domain | Separase-like, TPR repeats region | Separase-like, TPR repeats region | TPR_ESP1 | 4 |
IPR056935 | 56,935 | Histone acetyltransferase Rv0428c-like, C-terminal | Rv0428c-like_C | Domain | 4,803 | false | false | This entry represents the GNAT (GCN5-related N-acetyltransferase) domain found at the C terminus of Rv0428c from Mycobacterium tuberculosis and Cgl2740 from Corynebacterium glutamicum (cg3035, ), in association with . Rv0428c is a probable histone acetyltransferase that may be involved in survival under stress conditio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24553"
] | [
"Rv0428c_C"
] | [
4803
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155830",
"PUB00160335"
] | [
"35175508",
"24138314"
] | [
"A Phagosomally Expressed Gene, rv0428c, of Mycobacterium tuberculosis Demonstrates Acetyl Transferase Activity and Plays a Protective Role Under Stress Conditions.",
"A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum."
] | [
2022,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Dikarya",
"metagenomes"
] | [
3,
4729,
4,
67
] | 4 | [] | [] | 0 | true | Domain | Histone acetyltransferase Rv0428c-like, C-terminal | Histone acetyltransferase Rv0428c-like, C-terminal | Rv0428c-like_C | 5 |
IPR056937 | 56,937 | YqbQ/XkdQ | YqbQ/XkdQ | Domain | 1,882 | false | false | This entry represents a domain found standalone in the Uncharacterized protein YqbQ, Phage-like element PBSX protein XkdQ and other related proteins. This domain is also found N-terminal in Clostridioides difficile endolysin (Ecd09610, ), diffocin CD1368 [ ]. In diffocin CD1368, it adopts a globular structure comprised... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24032"
] | [
"YQBQ"
] | [
1882
] | 1 | [] | [] | [] | 0 | [
"8v3w",
"9g8s"
] | 2 | [
"PUB00160016"
] | [
"39152109"
] | [
"Atomic structures of a bacteriocin targeting Gram-positive bacteria."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
1716,
6,
16,
124,
20
] | 5 | [] | [] | 0 | true | Domain | YqbQ/XkdQ | YqbQ/XkdQ | YqbQ/XkdQ | 6 |
IPR056939 | 56,939 | Vps8, RING finger | Znf_RING_Vps8 | Domain | 1,871 | false | false | Vps8 is one of the Golgi complex components necessary for vacuolar sorting. It is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering). Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subun... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23412"
] | [
"zf_RING_Vps8"
] | [
1871
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00086665"
] | [
"25266290"
] | [
"Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations."
] | [
2014
] | 1 | [
"IPR001841"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1871
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
7
] | 4 | true | Domain | Vps8, RING finger | Vps8, RING finger | Znf_RING_Vps8 | 1 |
IPR056940 | 56,940 | PEX18/20/21, C-terminal domain | PEX18_20_21_C | Domain | 514 | false | false | This domain is found C-terminal in Peroxisomal membrane proteins PEX18, PEX20 and PEX21 from Saccharomyces cerevisiae. PEX18/20/21 are involved in peroxisome biogenesis and import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2 [ , , , ]. The crystal structure of the heterotrimeric P... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25098"
] | [
"PEX18_PEX21_C"
] | [
514
] | 1 | [] | [] | [] | 0 | [
"3w15"
] | 1 | [
"PUB00085400",
"PUB00159918",
"PUB00162450",
"PUB00162451"
] | [
"12167700",
"23812376",
"11606420",
"31042004"
] | [
"Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import.",
"Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p.",
"Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and m... | [
2002,
2013,
2001,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
514
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Domain | PEX18/20/21, C-terminal domain | PEX18/20/21, C-terminal domain | PEX18_20_21_C | 9 |
IPR056941 | 56,941 | RpoH-modulating protein-like | Mrh-like | Family | 327 | false | false | This entry represents RpoH-modulating protein from Enterobacteria phage T4 (Mrh), the uncharacterised Y01F from bacteriophage T4 and similar sequences from tailed bacteriophages. Mrh plays a role in transcriptional regulation of late T4 genes. It modulates the phosphorylation status of host heat shock sigma factor RpoH... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24070"
] | [
"T4_MRH"
] | [
327
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155855"
] | [
"9858714"
] | [
"Several new bacteriophage T4 genes, mapped by sequencing deletion endpoints between genes 56 (dCTPase) and dda (a DNA-dependent ATPase-helicase) modulate transcription."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
327
] | 1 | [] | [] | 0 | true | Family | RpoH-modulating protein-like | RpoH-modulating protein-like | Mrh-like | 2 |
IPR056942 | 56,942 | Phage head-tail joining protein | Phage_H_T_join | Domain | 82 | false | false | This entry is related to which is a phage protein that acts as a stopper to retain phage DNA in the capsid as well performing a head tail connector function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25138"
] | [
"Phage_H_T_join_3"
] | [
82
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"PVC group",
"marine sediment metagenome"
] | [
76,
6
] | 2 | [] | [] | 0 | true | Domain | Phage head-tail joining protein | Phage head-tail joining protein | Phage_H_T_join | 9 |
IPR056943 | 56,943 | Pikachurin, EGF-like domain | EGF_Pikachurin | Domain | 1,162 | false | false | This EFG-like domain is found in mouse Pikachurin, which is involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception [ , , ]. The fold of this domain consists of a two stranded β-sheet followed by a loop and a short two-stranded sheet. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25016"
] | [
"EGF_Pikachurin"
] | [
1162
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056677",
"PUB00154852",
"PUB00160017"
] | [
"18757743",
"30282023",
"18641643"
] | [
"Transcriptome-based systematic identification of extracellular matrix proteins.",
"Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.",
"Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse... | [
2008,
2018,
2008
] | 3 | [
"IPR000742"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1162
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
1,
7
] | 4 | true | Domain | Pikachurin, EGF-like domain | Pikachurin, EGF-like domain | EGF_Pikachurin | 3 |
IPR056944 | 56,944 | Tubby, C-terminal domain-like | Tubby_C-like | Domain | 607 | false | false | This entry represents a bacterial protein domain that is structurally similar to the C-terminal domain of the tubby protein. It consists of 12 β-strands organised into a barrel with a central C-terminal α-helix. It shows distant sequence similarity to both the Tubby C-terminal domain and the LURP 1 family. This domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23728"
] | [
"Tubby_C_like"
] | [
607
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
607
] | 1 | [] | [] | 0 | true | Domain | Tubby, C-terminal domain-like | Tubby, C-terminal domain-like | Tubby_C-like | 1 |
IPR056946 | 56,946 | YmcF-like | YmcF-like | Family | 574 | false | false | This protein family includes Protein YmcF from Escherichia coli and similar sequences from gammaproteobacteria. YmcF is a 62-residues long cold shock-regulated micropeptide encoded by an small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23641"
] | [
"YmcF-like"
] | [
574
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155924"
] | [
"28861998"
] | [
"Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coli."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"Myoviridae sp. ctGBP5"
] | [
573,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | YmcF-like | YmcF-like | YmcF-like | 7 |
IPR056947 | 56,947 | Pepco domain | Pepco_dom | Domain | 349 | false | false | This entry represents a small domain co-occurring with peptidases like Trypsin, Caspase, and MPTase. The domain is homologous to Trypco1 and Trypco2 from MoxR-vWA-based ternary systems typically seen in multicellular bacteria. Peptidase cleavage of Pepco superfamily domains may trigger assembly into multimeric complexe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24393"
] | [
"Pepco"
] | [
349
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098776",
"PUB00155486"
] | [
"32101166",
"37889040"
] | [
"Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.",
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2020,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"bioreactor metagenome"
] | [
345,
3,
1
] | 3 | [] | [] | 0 | true | Domain | Pepco domain | Pepco domain | Pepco_dom | 6 |
IPR056948 | 56,948 | Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A, N-terminal | PNGaseA_N | Domain | 4,549 | false | false | This domain is found at the N-terminal end of almond Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A, a protein capable of hydrolysing glycopeptides with an alpha-1,3-fucosylated asparagine-bound N-acetylglucosamine [ , ]. This domain is related to Peptide-N-glycosidases [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12222"
] | [
"PNGaseA"
] | [
4549
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053349",
"PUB00152314",
"PUB00152793"
] | [
"9523720",
"8940027",
"36419248"
] | [
"Characterisation of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A and its N-glycans.",
"Haemonchus contortus glycoproteins contain N-linked oligosaccharides with novel highly fucosylated core structures.",
"DALI shines a light on remote homologs: One hundred discoveries."
] | [
1998,
1996,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota"
] | [
81,
662,
3806
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
1,
14,
10
] | 4 | true | Domain | Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A, N-terminal | Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A, N-terminal | PNGaseA_N | 5 |
IPR056949 | 56,949 | CD59 glycoprotein | CD59 | Family | 1,146 | false | false | This entry represents the human CD59 glycoprotein and related proteins. CD59 is a cell-surface glycoprotein that protects host cells from complement-mediated lysis. It binds to and prevents the normal functioning of the complement proteins C8 and C9 which form part of a membrane penetrating assembly called the membrane... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF25152",
"cd23554"
] | [
"CD59",
"TFP_LU_ECD_CD59"
] | [
1111,
1071
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-204005",
"R-HSA-5694530",
"R-HSA-6798695",
"R-HSA-6807878",
"R-HSA-977606",
"R-MMU-204005",
"R-MMU-5694530",
"R-MMU-6798695",
"R-MMU-6807878",
"R-MMU-977606",
"R-RNO-204005",
"R-RNO-5694530",
"R-RNO-6798695",
"R-RNO-6807878",
"R-SSC-204005",
"R-SSC-5694530",
"R-SSC-6798695",
... | [
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU-5694530",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-6807878",
"REACTOME:R-MMU-977606",
"REACTOME:R-RNO-204005",
"REACTOME:R-R... | 19 | [
"1cdq",
"1cdr",
"1cds",
"1erg",
"1erh",
"2j8b",
"2ofs",
"2uwr",
"2ux2",
"4bik",
"5imt",
"5imy",
"6zd0",
"8b0f",
"8b0g",
"8b0h",
"8cn6"
] | 17 | [
"PUB00023914",
"PUB00036662",
"PUB00042177",
"PUB00047820",
"PUB00158026",
"PUB00158027",
"PUB00158028",
"PUB00158029",
"PUB00158030",
"PUB00158031",
"PUB00158032",
"PUB00158033",
"PUB00158034",
"PUB00158035",
"PUB00158036",
"PUB00158037",
"PUB00158038",
"PUB00158039",
"PUB001580... | [
"7520819",
"7512825",
"17505110",
"17671359",
"7507156",
"7507750",
"27499440",
"2475570",
"1689664",
"2475111",
"2606909",
"1692709",
"1381503",
"1383553",
"2476718",
"8670172",
"8276756",
"1377690",
"23149847",
"1382994",
"36797260"
] | [
"Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.",
"Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.",
"Crystal structure of CD59: implicati... | [
1994,
1994,
2007,
2007,
1993,
1993,
2016,
1989,
1990,
1989,
1989,
1990,
1992,
1992,
1989,
1996,
1993,
1992,
2013,
1992,
2023
] | 21 | [] | [] | 0 | 0 | null | [
"Gammaherpesvirinae",
"Gnathostomata"
] | [
4,
1142
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
12,
6,
5
] | 4 | true | Family | CD59 glycoprotein | CD59 glycoprotein | CD59 | 2 |
IPR056950 | 56,950 | Phage tail termination protein | Phage_tail_terminator_3 | Family | 457 | false | false | This entry represents the phage tail termination protein found in a variety of tailed phages that infect Enterobacter and prophages. These proteins form a hexameric ring that caps the tail tube at the neck of these bacteriophage. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23842"
] | [
"Phage_tail_terminator_3"
] | [
457
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota"
] | [
414,
39,
4
] | 3 | [] | [] | 0 | true | Family | Phage tail termination protein | Phage tail termination protein | Phage_tail_terminator_3 | 2 |
IPR056951 | 56,951 | Phage connector protein | Phage_connect_2 | Family | 428 | false | false | This entry represents a family of phage proteins that are structurally related to the HK97 gp6 protein that forms a head to tail connection. It is likely that these proteins form large homo-oligomeric rings. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24829"
] | [
"Phage_connect_2"
] | [
428
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"bioreactor metagenome"
] | [
280,
146,
2
] | 3 | [] | [] | 0 | true | Family | Phage connector protein | Phage connector protein | Phage_connect_2 | 9 |
IPR056952 | 56,952 | Phage T4 Cef protein | T4_Cef | Family | 254 | false | false | This entry represents proteins that are related to the phage T4 Protein Cef (also known as MotC, ). This protein adopts a compact globular domain composed of 5 β-strands and one α-helix. The β-strands adopt the order 1-5-4-3-2 with the α-helix found between strands 1 and 2. This family shows structural similarity to . ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24050"
] | [
"T4_Cef"
] | [
254
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160018"
] | [
"3999145"
] | [
"New control elements of bacteriophage T4 pre-replicative transcription."
] | [
1985
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
254
] | 1 | [] | [] | 0 | true | Family | Phage T4 Cef protein | Phage T4 Cef protein | T4_Cef | 8 |
IPR056953 | 56,953 | Cuticlin, N-terminal domain | CUT_N | Domain | 6,518 | false | false | This entry represents the N-terminal Ig-like domain of cuticlins 1/3-6 from C. elegans. Cuticlin is a component of the cuticles, which contributes to the formation of extracellular envelopes protecting the organism from the environment [ ]. It also plays a role in alae formation in dauer larvae [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25057"
] | [
"CUT_N"
] | [
6518
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159889",
"PUB00159890",
"PUB00159891"
] | [
"1864469",
"15936343",
"30409788"
] | [
"cut-1 a Caenorhabditis elegans gene coding for a dauer-specific noncollagenous component of the cuticle.",
"The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans.",
"Epidermal Remodeling in <i>Caenorhabditis e... | [
1991,
2005,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6518
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
35,
17
] | 2 | true | Domain | Cuticlin, N-terminal domain | Cuticlin, N-terminal domain | CUT_N | 9 |
IPR056958 | 56,958 | Phage tail tube initiator protein, putative | Phage_tail_tube_init_put | Family | 230 | false | false | This entry represents a family of uncharacterised proteins mainly found in phages and some bacterial species. Based on structure prediction these proteins show similarity to the Pam3 gp17 the tail tube initiator protein. Six gp17 subunits form a hexameric ring that initiates tail tube polymerisation from the baseplate. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23980"
] | [
"Phage_tail_tube_init"
] | [
230
] | 1 | [] | [] | [] | 0 | [
"9euf",
"9eug",
"9euh"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"marine sediment metagenome"
] | [
27,
202,
1
] | 3 | [] | [] | 0 | true | Family | Phage tail tube initiator protein, putative | Phage tail tube initiator protein, putative | Phage_tail_tube_init_put | 2 |
IPR056959 | 56,959 | RIIA.1-like | RIIA1-like | Family | 233 | false | false | This entry represents a family of small uncharacterised proteins found in phages, Uncharacterized 8.1 kDa protein in rIIA-Gp60 intergenic region [ ]. Structure prediction suggests the small proteins adopt a three-helical-bundle structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24210"
] | [
"T4_RIIA1"
] | [
233
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155856"
] | [
"2379817"
] | [
"The rIIA gene of bacteriophage T4. I. Its DNA sequence and discovery of a new open reading frame between genes 60 and rIIA."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
233
] | 1 | [] | [] | 0 | true | Family | RIIA.1-like | RIIA.1-like | RIIA1-like | 1 |
IPR056961 | 56,961 | Pseudouridylate synthase PUS7L, R3H domain | R3H_PUS7L | Domain | 961 | false | false | This R3H domain is found in human Pseudouridylate synthase PUS7L and related proteins from vertebrates. Human PUS7L catalyses pseudouridylation of RNAs [ , , , , ], acting also as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs). The pseu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25094"
] | [
"R3H_PUS7L"
] | [
961
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.99.-",
"PWY-7251",
"PWY-7419",
"PWY-7599",
"PWY-8341"
] | [
"EC:5.4.99.-",
"METACYC:PWY-7251",
"METACYC:PWY-7419",
"METACYC:PWY-7599",
"METACYC:PWY-8341"
] | 5 | [] | 0 | [
"PUB00100730",
"PUB00155816",
"PUB00160019",
"PUB00160020",
"PUB00160021",
"PUB00160022"
] | [
"31477916",
"35051350",
"28073919",
"29628141",
"30778726",
"34718722"
] | [
"mRNA structure determines modification by pseudouridine synthase 1.",
"Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.",
"TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code.",
"Pseudouridylation of t... | [
2019,
2022,
2017,
2018,
2019,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
961
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
1,
4
] | 4 | true | Domain | Pseudouridylate synthase PUS7L, R3H domain | Pseudouridylate synthase PUS7L, R3H domain | R3H_PUS7L | 8 |
IPR056962 | 56,962 | Phage blade protein | Phage_blade | Family | 209 | false | false | This entry represents a small family of short uncharacterised phage proteins including Uncharacterized 7.2 kDa protein in alt-Gp30 intergenic region from Bacteriophage T4 ( ). Structure prediction of suggests the protein adopts a four stranded β-sheet that can form homo-oligomers, with a homohexamer forming a β-propell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24647"
] | [
"Phage_blade"
] | [
209
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
209
] | 1 | [] | [] | 0 | true | Family | Phage blade protein | Phage blade protein | Phage_blade | 3 |
IPR056963 | 56,963 | Pseudouridylate synthase PUS7L, N-terminal domain | PUS7L_N | Domain | 1,313 | false | false | This domain is found N-terminal in the human Pseudouridylate synthase PUS7L and related proteins from vertebrates, ascomycetes and plants. This domain is predicted to adopt a globular structure consisting of a three-stranded antiparallel β-sheet with two α-helices packed on one side of it. Human PUS7L catalyses pseudou... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23943"
] | [
"PUS7L_N"
] | [
1313
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.99.-",
"PWY-7251",
"PWY-7419",
"PWY-7599",
"PWY-8341"
] | [
"EC:5.4.99.-",
"METACYC:PWY-7251",
"METACYC:PWY-7419",
"METACYC:PWY-7599",
"METACYC:PWY-8341"
] | 5 | [] | 0 | [
"PUB00100730",
"PUB00155816",
"PUB00160019",
"PUB00160020",
"PUB00160021",
"PUB00160022"
] | [
"31477916",
"35051350",
"28073919",
"29628141",
"30778726",
"34718722"
] | [
"mRNA structure determines modification by pseudouridine synthase 1.",
"Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.",
"TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code.",
"Pseudouridylation of t... | [
2019,
2022,
2017,
2018,
2019,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1313
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
1,
4
] | 4 | true | Domain | Pseudouridylate synthase PUS7L, N-terminal domain | Pseudouridylate synthase PUS7L, N-terminal domain | PUS7L_N | 3 |
IPR056964 | 56,964 | Putative phage holin 2 | Phage_holin | Family | 308 | false | false | This entry represents a family of putative holin proteins found in various phages infecting actinobacterial hosts, particularly Gordonia, Mycobacterium, Arthrobacter, and Microbacterium. Holins are small membrane proteins involved in the timing of host cell lysis during bacteriophage infection. Members of this family t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23778"
] | [
"Phage_holin_2"
] | [
308
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes"
] | [
147,
161
] | 2 | [] | [] | 0 | true | Family | Putative phage holin 2 | Putative phage holin 2 | Phage_holin | 1 |
IPR056965 | 56,965 | CDCP1, fourth CUB domain | CUB_CDCP1_4th | Domain | 728 | false | false | This domain is found in the human CUB domain-containing protein 1 (CDCP1) and related proteins. This entry represents the fourth of the tandem of CUB domains. CDCP1 may be involved in cell adhesion and cell matrix association. It also plays a role in the regulation of anchorage versus migration or proliferation versus ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25142"
] | [
"CUB_CDCP1_4th"
] | [
728
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155580",
"PUB00155581"
] | [
"11466621",
"15153610"
] | [
"Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.",
"CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin."
] | [
2001,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
728
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2
] | 3 | true | Domain | CDCP1, fourth CUB domain | CDCP1, fourth CUB domain | CUB_CDCP1_4th | 2 |
IPR056967 | 56,967 | Dep-1, first Fn3-like domain | Fn3_Dep-1_1st | Domain | 117 | false | false | This entry represents the first Fn3-like domain. This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the β-integrin subunit pat-3. It is involved in the regulation of the cell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24942"
] | [
"Fn3_Dep-1_1st"
] | [
117
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-CEL-6807004"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807004"
] | 2 | [] | 0 | [
"PUB00159896",
"PUB00159897"
] | [
"15901674",
"28135265"
] | [
"The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.",
"β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans."
] | [
2005,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
117
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Dep-1, first Fn3-like domain | Dep-1, first Fn3-like domain | Fn3_Dep-1_1st | 1 |
IPR056968 | 56,968 | Dep-1, second Fn3-like domain | Fn3_Dep-1_2nd | Domain | 129 | false | false | This entry represents the second Fn3-like domain. This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the β-integrin subunit pat-3. It is involved in the regulation of the cel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24943"
] | [
"Fn3_Dep-1_2nd"
] | [
129
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-CEL-6807004"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807004"
] | 2 | [] | 0 | [
"PUB00159896",
"PUB00159897"
] | [
"15901674",
"28135265"
] | [
"The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.",
"β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans."
] | [
2005,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
129
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Dep-1, second Fn3-like domain | Dep-1, second Fn3-like domain | Fn3_Dep-1_2nd | 7 |
IPR056969 | 56,969 | Dep-1, sixth Fn3-like domain | Fn3_Dep-1_6th | Domain | 127 | false | false | This entry represents the sixth Fn3-like domain. This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the β-integrin subunit pat-3. It is involved in the regulation of the cell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24950"
] | [
"Fn3_Dep-1_6th"
] | [
127
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-CEL-6807004"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807004"
] | 2 | [] | 0 | [
"PUB00159896",
"PUB00159897"
] | [
"15901674",
"28135265"
] | [
"The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.",
"β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans."
] | [
2005,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
127
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Dep-1, sixth Fn3-like domain | Dep-1, sixth Fn3-like domain | Fn3_Dep-1_6th | 9 |
IPR056970 | 56,970 | Dep-1, fourth Fn3-like domain | Fn3_Dep-1_4th | Domain | 153 | false | false | This entry represents the fourth Fn3-like domain. This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the β-integrin subunit pat-3. It is involved in the regulation of the cel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24946"
] | [
"Fn3_Dep-1_4th"
] | [
153
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-CEL-6807004"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807004"
] | 2 | [] | 0 | [
"PUB00159896",
"PUB00159897"
] | [
"15901674",
"28135265"
] | [
"The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.",
"β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans."
] | [
2005,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
153
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Dep-1, fourth Fn3-like domain | Dep-1, fourth Fn3-like domain | Fn3_Dep-1_4th | 5 |
IPR056971 | 56,971 | C2HC zinc finger, plants | Znf-C2HC_3 | Domain | 669 | false | false | This domain is found at the C-terminal of uncharacterised plant proteins. It has three invariant cysteine residues and a histidine that are likely involved in metal coordination. It is probably a variant of the classical C2H2 zinc fingers and is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25017"
] | [
"zf-C2HC_3"
] | [
669
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
669
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
2,
4
] | 3 | true | Domain | C2HC zinc finger, plants | C2HC zinc finger, plants | Znf-C2HC_3 | 5 |
IPR056972 | 56,972 | Ribbon-helix-helix domain containing protein | RHH_dom-containing | Family | 507 | false | false | This entry represents a family of phage Ribbon-Helix-Helix (RHH) domain containing proteins and proteobacterial prophages. Members of the RHH superfamily are often parts of toxin/antitoxin systems, suggesting these proteins may form part of a phage immunity response. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23807"
] | [
"RHH_10"
] | [
507
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"ecological metagenomes"
] | [
303,
198,
6
] | 3 | [] | [] | 0 | true | Family | Ribbon-helix-helix domain containing protein | Ribbon-helix-helix domain containing protein | RHH_dom-containing | 9 |
IPR056973 | 56,973 | Phage L5 gene 47 protein-like | Phage_L5_Gp47 | Family | 158 | false | false | This entry represents the gene 47 protein found in Mycobacterium phage L5 and related proteins from tailed bacteriophages. This protein forms a small globular β-barrel domain that is related to LSM superfamily proteins such as Hfq. AlphaFold modelling suggests this protein forms an unusual octameric arrangement. Based ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23887"
] | [
"Phage_Gene47"
] | [
158
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
5,
153
] | 2 | [] | [] | 0 | true | Family | Phage L5 gene 47 protein-like | Phage L5 gene 47 protein-like | Phage_L5_Gp47 | 8 |
IPR056974 | 56,974 | Tail assembly protein gp4-like | Tail_Gp41-like | Family | 309 | false | false | This entry includes the probable tail assembly protein gp41 from Bacteriophage Mu (Mup41 and FS-gp41) and Mu-like prophage FluMu protein gp41 from H. influenzae. Mup41 and FS-gp41 may act as a chaperone mediating the interaction between the tape measure protein (TMP) and the tail tube protein (TTP) thereby directing th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23746"
] | [
"Gp41_Mu"
] | [
309
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Pseudomonadati",
"metagenomes"
] | [
6,
301,
2
] | 3 | [] | [] | 0 | true | Family | Tail assembly protein gp4-like | Tail assembly protein gp4-like | Tail_Gp41-like | 6 |
IPR056975 | 56,975 | HTH-like domain, bact | HTH_73 | Domain | 334 | false | false | This entry represents a domain that covers the whole length of the sequence in a group of uncharacterised bacterial proteins. Proteins in this family are approximately 80 amino acids in length. These proteins structurally resemble a HTH domain. They are often found genomically associated with likely restriction modific... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24718"
] | [
"HTH_73"
] | [
334
] | 1 | [] | [] | [] | 0 | [
"9r2z"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
329,
5
] | 2 | [] | [] | 0 | true | Domain | HTH-like domain, bact | HTH-like domain, bact | HTH_73 | 4 |
IPR056976 | 56,976 | Reversion-inducing cysteine-rich protein with Kazal, EGF-like 1 domain | EGF1_RECK | Domain | 1,776 | false | false | This domain is found in human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and similar animal proteins. RECK consists of five repeats of an uncommon domain with six cysteines (the CC domain, represented by and two copies of ), a Frizzled-like cysteine-rich domain (Fz-like CRD, ), two epidermal grow... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25027"
] | [
"EGF1_RECK"
] | [
1776
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 3 | [
"8tzp"
] | 1 | [
"PUB00088748",
"PUB00088750",
"PUB00088751",
"PUB00088752",
"PUB00088753",
"PUB00154871",
"PUB00154886"
] | [
"9789069",
"28803732",
"28858624",
"18498076",
"11747814",
"37852257",
"30026314"
] | [
"Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.",
"Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.",
"Ligand-Selective Wnt Receptor Complex... | [
1998,
2017,
2017,
2008,
2001,
2023,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1776
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
2,
6
] | 5 | true | Domain | Reversion-inducing cysteine-rich protein with Kazal, EGF-like 1 domain | Reversion-inducing cysteine-rich protein with Kazal, EGF-like 1 domain | EGF1_RECK | 1 |
IPR056977 | 56,977 | Reversion-inducing cysteine-rich protein with Kazal, fibronectin type I module | FnI_RECK | Domain | 1,611 | false | false | This domain is found in human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and similar animal proteins. RECK consists of five repeats of an uncommon domain with six cysteines (the CC domain, represented by and two copies of ), a Frizzled-like cysteine-rich domain (Fz-like CRD, ), two epidermal grow... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25028"
] | [
"FnI_RECK"
] | [
1611
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 3 | [
"8tzp"
] | 1 | [
"PUB00088748",
"PUB00088750",
"PUB00088751",
"PUB00088752",
"PUB00088753",
"PUB00154871",
"PUB00154886"
] | [
"9789069",
"28803732",
"28858624",
"18498076",
"11747814",
"37852257",
"30026314"
] | [
"Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.",
"Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.",
"Ligand-Selective Wnt Receptor Complex... | [
1998,
2017,
2017,
2008,
2001,
2023,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1611
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
2,
6
] | 5 | true | Domain | Reversion-inducing cysteine-rich protein with Kazal, fibronectin type I module | Reversion-inducing cysteine-rich protein with Kazal, fibronectin type I module | FnI_RECK | 2 |
IPR056979 | 56,979 | Reversion-inducing cysteine-rich protein with Kazal, frizzled-like domain | FZ_RECK | Domain | 1,854 | false | false | This entry includes human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and similar animal proteins. This entry represents a frizzled-like domain which contains ten conserved cysteine residues. RECK consists of five repeats of an uncommon domain with six cysteines (the CC domain, represented by and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23298"
] | [
"FZ_RECK"
] | [
1854
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-HSA-163125",
"R-MMU-163125"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-HSA-163125",
"REACTOME:R-MMU-163125"
] | 3 | [
"8tzp"
] | 1 | [
"PUB00088748",
"PUB00088750",
"PUB00088751",
"PUB00088752",
"PUB00088753",
"PUB00154871",
"PUB00154886"
] | [
"9789069",
"28803732",
"28858624",
"18498076",
"11747814",
"37852257",
"30026314"
] | [
"Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.",
"Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.",
"Ligand-Selective Wnt Receptor Complex... | [
1998,
2017,
2017,
2008,
2001,
2023,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1854
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
2,
6
] | 5 | true | Domain | Reversion-inducing cysteine-rich protein with Kazal, frizzled-like domain | Reversion-inducing cysteine-rich protein with Kazal, frizzled-like domain | FZ_RECK | 4 |
IPR056980 | 56,980 | RUNKEL, ARM-repeat domain | ARM_RUK | Domain | 731 | false | false | This is the C-terminal domain of Serine/threonine-protein kinase RUNKEL from Arabidopsis thaliana and related plant sequences. It consists of ARM repeats. RUNKEL is an essential protein that regulates phragmoplast microtubule organisation during cell plate expansion in cytokinesis during cell division, both somatic and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24970"
] | [
"ARM_RUK"
] | [
731
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096505",
"PUB00096506"
] | [
"23451828",
"19268593"
] | [
"The microtubule-associated kinase-like protein RUNKEL functions in somatic and syncytial cytokinesis.",
"Microtubule-associated kinase-like protein RUNKEL needed [corrected] for cell plate expansion in Arabidopsis cytokinesis."
] | [
2013,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
731
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
3,
29
] | 3 | true | Domain | RUNKEL, ARM-repeat domain | RUNKEL, ARM-repeat domain | ARM_RUK | 8 |
IPR056981 | 56,981 | Serine/threonine-protein kinase ULK4/RUNKEL, HEAT repeats | HEAT_ULK4_RUNKEL | Domain | 2,055 | false | false | This region of HEAT repeats is found in human Serine/threonine-protein kinase ULK4, Serine/threonine-protein kinase RUNKEL from Arabidopsis thaliana and similar sequences mainly found in animals and plants. ULK4 may be involved in the remodelling of cytoskeletal components and in the regulation of neurite branching and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23606"
] | [
"HEAT_ULK4"
] | [
2055
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [
"PUB00096505",
"PUB00096506",
"PUB00099283"
] | [
"23451828",
"19268593",
"24284070"
] | [
"The microtubule-associated kinase-like protein RUNKEL functions in somatic and syncytial cytokinesis.",
"Microtubule-associated kinase-like protein RUNKEL needed [corrected] for cell plate expansion in Arabidopsis cytokinesis.",
"Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis a... | [
2013,
2009,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2055
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
5,
1,
3,
3,
3,
48
] | 7 | true | Domain | Serine/threonine-protein kinase ULK4/RUNKEL, HEAT repeats | Serine/threonine-protein kinase ULK4/RUNKEL, HEAT repeats | HEAT_ULK4_RUNKEL | 4 |
IPR056982 | 56,982 | Phage ProQ RNA-binding domain, C-terminal-like | Phage_ProQ_C-like | Family | 229 | false | false | This entry represents a family of uncharacterised phage and bacterial proteins. Structurally the proteins include an N-terminal β-barrel domain that shows some structural similarity to the C-terminal domain of the ProQ RNA-binding domain. That domain has been described as being similar to the Tudor domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24203"
] | [
"Phage_ProQ_C_like"
] | [
229
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
128,
97,
4
] | 3 | [] | [] | 0 | true | Family | Phage ProQ RNA-binding domain, C-terminal-like | Phage ProQ RNA-binding domain, C-terminal-like | Phage_ProQ_C-like | 1 |
IPR056983 | 56,983 | SAMD1-like, small helical domain | SAMD1-like_SHD | Domain | 344 | false | false | This domain is found in the human Sterile alpha motif domain-containing protein 1 (SAMD1) and its homologues from vertebrates. SAMD1 directly recognises and binds unmethylated CpG-containing DNA via simultaneous interactions with both the major and the minor groove [ ]. SAMD1 acts as a transcriptional repressor and chr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24971"
] | [
"SAMD1_SHD"
] | [
344
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151825",
"PUB00159931"
] | [
"33980486",
"34006929"
] | [
"The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.",
"The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions."
] | [
2021,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
344
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
1
] | 4 | true | Domain | SAMD1-like, small helical domain | SAMD1-like, small helical domain | SAMD1-like_SHD | 8 |
IPR056984 | 56,984 | Repressor Rok, winged helix domain | WH_Rok | Domain | 288 | false | false | This entry represents the C-terminal domain of repressor Rok from Bacillus subtilis. This domain shows a typical winged helix fold, with a novel DNA recognition mechanism different from other winged helix proteins or xenogeneic silencers. Rok is a nucleoid-associated protein that functions as a transcriptional represso... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23159"
] | [
"WHD_Rok"
] | [
288
] | 1 | [] | [] | [] | 0 | [
"5zux",
"5zuz"
] | 2 | [
"PUB00155922",
"PUB00161446",
"PUB00161448"
] | [
"30252102",
"21085634",
"11849533"
] | [
"How bacterial xenogeneic silencer rok distinguishes foreign from self DNA in its resident genome.",
"The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis.",
"Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly r... | [
2018,
2010,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes"
] | [
255,
33
] | 2 | [] | [] | 0 | true | Domain | Repressor Rok, winged helix domain | Repressor Rok, winged helix domain | WH_Rok | 9 |
IPR056986 | 56,986 | Protein jagged-1/2, predicted ferredoxin-like domain | JAG1_1/2_dom | Domain | 3,957 | false | false | This domain is found in human Protein jagged-1/2 (JAG1, JAG2) and similar proteins from vertebrates. JAG1 is involved in the mediation of Notch signalling. This domain is predicted to show a ferredoxin-like fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23575"
] | [
"JAG1"
] | [
3957
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-1912420",
"R-DME-9013700",
"R-DME-9604323",
"R-DRE-2979096",
"R-HSA-2122948",
"R-HSA-2644606",
"R-HSA-2660826",
"R-HSA-2691232",
"R-HSA-2894862",
"R-HSA-2979096",
"R-HSA-8941856",
"R-HSA-9013149",
"R-HSA-9013423",
"R-HSA-9013507",
"R-HSA-9013700",
"R-HSA-9831926",
"R-MMU-21229... | [
"REACTOME:R-DME-1912420",
"REACTOME:R-DME-9013700",
"REACTOME:R-DME-9604323",
"REACTOME:R-DRE-2979096",
"REACTOME:R-HSA-2122948",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2660826",
"REACTOME:R-HSA-2691232",
"REACTOME:R-HSA-2894862",
"REACTOME:R-HSA-2979096",
"REACTOME:R-HSA-8941856",
"REACTOM... | 24 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3957
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
1,
5,
6,
10
] | 5 | true | Domain | Protein jagged-1/2, predicted ferredoxin-like domain | Protein jagged-1/2, predicted ferredoxin-like domain | JAG1_1/2_dom | 1 |
IPR056987 | 56,987 | ZMYND8, coiled-coil | ZMYND8_CC | Domain | 4,121 | false | false | This entry represents a coiled-coil domain that is predicted to self associate to form a dimeric arrangement found in human and fly MYND-type zinc finger-containing chromatin reader ZMYND8 and similar animal proteins. The coiled coil is adjacent to a MYND zinc finger and is similar to that found in ZMYND11 [ ]. The ZMY... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23460"
] | [
"ZMYND8_CC"
] | [
4121
] | 1 | [] | [] | [] | 0 | [
"5mq4",
"9wv4"
] | 2 | [
"PUB00103298",
"PUB00103632",
"PUB00103633",
"PUB00103636",
"PUB00103688",
"PUB00155752"
] | [
"30134174",
"36064715",
"31965980",
"27732854",
"35916866",
"26845565"
] | [
"Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.",
"ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.",
"A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding... | [
2018,
2022,
2020,
2016,
2022,
2016
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4121
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
1,
4,
12,
8
] | 5 | true | Domain | ZMYND8, coiled-coil | ZMYND8, coiled-coil | ZMYND8_CC | 4 |
IPR056988 | 56,988 | Zinc beta-ribbon domain, plants | Zn_ribbon_pln | Domain | 3,927 | false | false | This domain is found in a group of uncharacterised proteins from plants. It is predicted to adopt a zinc β-ribbon fold and contains a pair of highly conserved CxxC sequence motifs. This domain is frequently found in combination with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23551"
] | [
"Zn_ribbon_20"
] | [
3927
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
3927
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
47,
18,
27
] | 3 | true | Domain | Zinc beta-ribbon domain, plants | Zinc beta-ribbon domain, plants | Zn_ribbon_pln | 3 |
IPR056990 | 56,990 | VIN3-like, C-terminal domain | VIN3-like_C | Domain | 2,501 | false | false | This domain is found at the C-terminal end of Protein Vernalization Insensitive 3 from Arabidopsis thaliana (VIN3) and similar plant sequences, including VIN3-like protein 1/2/3 [ , ]. This domain, predicted to adopt an all-α structure, is often found associated with and . VIN3 plays a central role in vernalization by ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23380"
] | [
"VIN3_C"
] | [
2501
] | 1 | [] | [] | [] | 0 | [
"7o6t",
"7o6u",
"7o6v",
"7o6w",
"7oqv"
] | 5 | [
"PUB00076963",
"PUB00132801"
] | [
"17114575",
"14712276"
] | [
"A PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis.",
"Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3."
] | [
2006,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
2501
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
8,
45
] | 3 | true | Domain | VIN3-like, C-terminal domain | VIN3-like, C-terminal domain | VIN3-like_C | 4 |
IPR056991 | 56,991 | Thrombospondin type-1 domain-containing protein 7A/ 7B, C-terminal TSP1 domain | TSP1_TSH7A-B_C | Domain | 2,402 | false | false | This entry represents the C-terminal Thrombospondin type-1 (TSP1) domain of Thrombospondin type-1 domain-containing protein 7A and 7B from vertebrates. THSD7A is a neural protein that affects endothelial migration and vascular patterning during development [ , ]. THSD7A is a membrane-associated N-glycoprotein with a so... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23308"
] | [
"TSP1_TSH7A-B_C"
] | [
2402
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5173214",
"R-HSA-5083635",
"R-HSA-5173214",
"R-MMU-5173214"
] | [
"REACTOME:R-DRE-5173214",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-MMU-5173214"
] | 4 | [] | 0 | [
"PUB00155889",
"PUB00155890"
] | [
"22194972",
"27214550"
] | [
"Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis.",
"Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy."
] | [
2011,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2402
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
2,
4,
5
] | 4 | true | Domain | Thrombospondin type-1 domain-containing protein 7A/ 7B, C-terminal TSP1 domain | Thrombospondin type-1 domain-containing protein 7A/ 7B, C-terminal TSP1 domain | TSP1_TSH7A-B_C | 5 |
IPR056992 | 56,992 | Argonaute protein hrde-1/Nuclear RNAi defective-3 protein-like, N-terminal domain | HRDE1/NRDE-3-like_N | Domain | 88 | false | false | This domain is found at the N-terminal of Argonaute protein hrde-1 (HRDE1, also known as C16C10.3) and nuclear RNAi defective-3 protein (NRDE-3) from Caenorhabditis elegans and relates sequences from nematodes. This domain is predicted to adopt an α/β configuration. HRDE1 is an argonaute protein which is involved in th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25128"
] | [
"HRDE1_NRDE3_N"
] | [
88
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160024",
"PUB00160025",
"PUB00160026",
"PUB00160027",
"PUB00160028",
"PUB00160029"
] | [
"22810588",
"28533440",
"37083324",
"18653886",
"26365259",
"34365510"
] | [
"A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality.",
"The RNAi Inheritance Machinery of <i>Caenorhabditis elegans</i>.",
"The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing.",
"A... | [
2012,
2017,
2023,
2008,
2015,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Rhabditida"
] | [
88
] | 1 | [
"Caenorhabditis elegans"
] | [
3
] | 1 | true | Domain | Argonaute protein hrde-1/Nuclear RNAi defective-3 protein-like, N-terminal domain | Argonaute protein hrde-1/Nuclear RNAi defective-3 protein-like, N-terminal domain | HRDE1/NRDE-3-like_N | 8 |
IPR056993 | 56,993 | Activating signal cointegrator 1, third domain | TRIP4_3rd_dom | Domain | 2,419 | false | false | This entry represents a presumed domain found in Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related sequences from animals and some plant species. The function of this domain is unknown. TRIP4 is the orthologue of yeast RQT4 and is part of the RQC trigger (RQT) complex that activates t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23134"
] | [
"TRIP4_3rd"
] | [
2419
] | 1 | [] | [] | [] | 0 | [
"8alz"
] | 1 | [
"PUB00071531",
"PUB00088961",
"PUB00151150",
"PUB00151151",
"PUB00151152"
] | [
"10454579",
"25219498",
"32099016",
"32579943",
"36302773"
] | [
"Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.",
"Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.",
"Identification of a novel trigger complex that fac... | [
1999,
2014,
2020,
2020,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2419
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
2,
3,
2,
3,
11,
4
] | 9 | true | Domain | Activating signal cointegrator 1, third domain | Activating signal cointegrator 1, third domain | TRIP4_3rd_dom | 3 |
IPR056994 | 56,994 | Activating signal cointegrator 1, N-terminal | TRI4_N | Domain | 1,481 | false | false | This entry represents a presumed domain found at the N-terminal of Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related animal sequences. The function of this domain is unknown. According to structure predictions, this domain may adopt a four helical bundle fold. TRIP4 is the orthologue ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23135"
] | [
"TRI4_N"
] | [
1481
] | 1 | [] | [] | [] | 0 | [
"8alz"
] | 1 | [
"PUB00071531",
"PUB00088961",
"PUB00151150",
"PUB00151151",
"PUB00151152"
] | [
"10454579",
"25219498",
"32099016",
"32579943",
"36302773"
] | [
"Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.",
"Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.",
"Identification of a novel trigger complex that fac... | [
1999,
2014,
2020,
2020,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1481
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
4,
11
] | 4 | true | Domain | Activating signal cointegrator 1, N-terminal | Activating signal cointegrator 1, N-terminal | TRI4_N | 5 |
IPR056996 | 56,996 | SLA1-like, PH domain-like | PH_SLA1 | Domain | 1,753 | false | false | This domain is found in Actin cytoskeleton-regulatory complex protein SLA1 from Saccharomyces cerevisiae and similar proteins from ascomycetes. SLA1 is a component of the PAN1 actin cytoskeleton-regulatory complex required for the internalisation of endosomes during actin-coupled endocytosis [ , , , ]. This domain is p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24081"
] | [
"PH_SLA1"
] | [
1753
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SCE-9013406",
"R-SCE-9696270",
"R-SPO-8856828",
"R-SPO-9013406",
"R-SPO-9696270"
] | [
"REACTOME:R-SCE-9013406",
"REACTOME:R-SCE-9696270",
"REACTOME:R-SPO-8856828",
"REACTOME:R-SPO-9013406",
"REACTOME:R-SPO-9696270"
] | 5 | [] | 0 | [
"PUB00020335",
"PUB00071605",
"PUB00129266",
"PUB00129270"
] | [
"10594004",
"11739778",
"17286805",
"11950888"
] | [
"Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis.",
"Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p.",
"Nucleocy... | [
2000,
2001,
2007,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1753
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Domain | SLA1-like, PH domain-like | SLA1-like, PH domain-like | PH_SLA1 | 6 |
IPR056997 | 56,997 | Arabinofuranosyltransferase D, third carbohydrate binding module | CBM_AftD | Domain | 1,530 | false | false | This is the third carbohydrate binding module (CBM) found in Arabinofuranosyltransferase D from Mycolicibacterium smegmatis (AftD, also known as Alpha-(1->3)-arabinofuranosyltransferase) and similar proteins from actinomycetes. The membrane embedded portion of AftD contains a typical GT-C glycosyltransferase domain ( )... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24607"
] | [
"CBM_AftD"
] | [
1530
] | 1 | [] | [] | [] | 0 | [
"6w98",
"6wbx",
"6wby"
] | 3 | [
"PUB00155574",
"PUB00155575"
] | [
"32386575",
"20561530"
] | [
"Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria.",
"Structure and specificity of a binary tandem domain F-lectin from striped bass (Morone saxatilis)."
] | [
2020,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"freshwater metagenome"
] | [
1507,
1,
22
] | 3 | [] | [] | 0 | true | Domain | Arabinofuranosyltransferase D, third carbohydrate binding module | Arabinofuranosyltransferase D, third carbohydrate binding module | CBM_AftD | 8 |
IPR056998 | 56,998 | Asd-4/GZF3-like, helical region | Asd-4/GZF3_helical | Domain | 1,173 | false | false | This entry represents a helical region found in GATA type zinc finger protein asd-4 from Neurospora crassa (Asd-4), transcriptional regulator GZF3 from Candida albicans and similar fungal proteins. Asd-4 is a transcriptional regulator that functions in sexual development. GZF3 is transcription factor involved in respon... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25026"
] | [
"Asd-4"
] | [
1173
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1173
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Asd-4/GZF3-like, helical region | Asd-4/GZF3-like, helical region | Asd-4/GZF3_helical | 1 |
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