Datasets:
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InterPro

Dataset card Data Studio Files
xet
 Community
interpro_id
string
interpro_numeric_id
int64
name
string
short_name
string
entry_type
string
protein_count
int64
is_llm
bool
is_llm_reviewed
bool
abstract
string
go_ids
list
go_terms
list
go_categories
list
go_count
int64
member_databases
list
member_accessions
list
member_names
list
member_protein_counts
list
member_count
int64
external_databases
list
external_accessions
list
external_xrefs
list
external_xref_count
int64
pdb_ids
list
structure_count
int64
publication_ids
list
pubmed_ids
list
publication_titles
list
publication_years
list
publication_count
int64
parent_ids
list
child_ids
list
parent_count
int64
child_count
int64
tree_depth
float64
taxonomy_names
list
taxonomy_protein_counts
list
taxonomy_count
int64
key_species_names
list
key_species_protein_counts
list
key_species_count
int64
in_entry_list
bool
entry_list_type
string
entry_list_name
string
names_dat_name
string
short_names_dat_name
string
split_bucket
int64
IPR056518
56,518
Ints3-like, C-terminal
HEAT_Ints3_C
Domain
2,179
false
false
This is the C-terminal domain of human Integrator complex subunit 3 (Ints3) and its homologues. Ints3 is a component of the Integrator (INT) complex, which is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. This domain forms a dimer, which binds single-strand...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24566" ]
[ "HEAT_Ints3_C" ]
[ 2179 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DDI-6807505", "R-DME-6807505", "R-DRE-6807505", "R-HSA-6807505", "R-MMU-6807505" ]
[ "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]
5
[ "6wlg", "7bv7", "8hpp", "8rbz" ]
4
[ "PUB00155657", "PUB00155658" ]
[ "33434574", "34400606" ]
[ "Structural basis for multifunctional roles of human Ints3 C-terminal domain.", "Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair." ]
[ 2021, 2021 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2179 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 1, 1, 1, 3, 3 ]
6
true
Domain
Ints3-like, C-terminal
Ints3-like, C-terminal
HEAT_Ints3_C
4
IPR056519
56,519
KANSL3, helical domain
KANSL3_1st
Domain
2,275
false
false
This domain is found in human KAT8 regulatory NSL complex subunit 3 (KANSL3) and its homologues. KANSL3 is a non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and prom...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23154" ]
[ "KANSL3_1st" ]
[ 2275 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-3214847", "R-HSA-9772755", "R-MMU-3214847", "R-MMU-9772755", "R-RNO-3214847", "R-RNO-9772755" ]
[ "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-3214847", "REACTOME:R-MMU-9772755", "REACTOME:R-RNO-3214847", "REACTOME:R-RNO-9772755" ]
6
[]
0
[ "PUB00060167", "PUB00158874", "PUB00158875" ]
[ "20018852", "33657400", "27768893" ]
[ "Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.", "Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.", "MOF Acetyl Transferase Regulates Tr...
[ 2010, 2021, 2016 ]
3
[]
[]
0
0
null
[ "Metazoa" ]
[ 2275 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 27, 8, 3, 1, 3 ]
6
true
Domain
KANSL3, helical domain
KANSL3, helical domain
KANSL3_1st
5
IPR056521
56,521
E3 ubiquitin-protein ligase MARCHF6-like, C-terminal domain
MARCHF6-like_C
Domain
5,471
false
false
This domain is found at the C-terminal end of human E3 ubiquitin-protein ligase MARCHF6, its homologue in Schizosaccharomyces pombe Doa10 and similar eukaryotic sequences. MARCHF6 promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation [ , ]. This domain is predicted to adop...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23113" ]
[ "MARCHF6_C" ]
[ 5471 ]
1
[ "EC", "METACYC", "REACTOME" ]
[ "2.3.2.27", "PWY-7511", "R-HSA-901032" ]
[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-901032" ]
3
[]
0
[ "PUB00137900", "PUB00137902" ]
[ "24449766", "15673284" ]
[ "The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.", "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum." ]
[ 2014, 2005 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5471 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...
[ 18, 1, 4, 3, 3, 2, 1, 8, 2, 1, 15 ]
11
true
Domain
E3 ubiquitin-protein ligase MARCHF6-like, C-terminal domain
E3 ubiquitin-protein ligase MARCHF6-like, C-terminal domain
MARCHF6-like_C
3
IPR056522
56,522
Uncharacterized bromodomain-containing protein 10, helical domain
KIAA2026_hel
Domain
1,219
false
false
This entry represents an helical domain found in the uncharacterised bromodomain-containing protein 10 (BRD10, also known as KIAA2026) humans and similar sequences, whose function is currently unknown. This domain is found towards the N-terminal end and may adopt an all-helical structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF23450" ]
[ "KIAA2026_hel" ]
[ 1219 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1219 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 3, 4 ]
4
true
Domain
Uncharacterized bromodomain-containing protein 10, helical domain
Uncharacterized bromodomain-containing protein 10, helical domain
KIAA2026_hel
5
IPR056523
56,523
KIF14, four-helical bundle
4HB_KIF14
Domain
1,028
false
false
This is a four helical bundle domain (4HB) found in Kinesin-like protein KIF14, a microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. It plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apop...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23313" ]
[ "4HB_KIF14" ]
[ 1028 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5625900", "R-HSA-9696270", "R-HSA-9696273", "R-MMU-5625900", "R-MMU-9696270", "R-MMU-9696273" ]
[ "REACTOME:R-HSA-5625900", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-5625900", "REACTOME:R-MMU-9696270", "REACTOME:R-MMU-9696273" ]
6
[]
0
[ "PUB00109959" ]
[ "24784001" ]
[ "KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer." ]
[ 2014 ]
1
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 1028 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 2, 3, 1 ]
4
true
Domain
KIF14, four-helical bundle
KIF14, four-helical bundle
4HB_KIF14
9
IPR056524
56,524
Kinesin-like protein KIF6/9, C-terminal
KIF6/9_C
Domain
3,065
false
false
This entry represents a region found at the C-terminal of Kinesin-like protein KIF6 and 9 from animals and KIF1 from Chlamydomonas reinhardtii. KIF9 is essential for normal male fertility and for progressive motility of spermatozoa. This region, which is predicted to form two long α-helices, is often found associated w...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23735" ]
[ "KIF9" ]
[ 3065 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-6811434", "R-HSA-983189", "R-MMU-2132295", "R-MMU-6811434", "R-MMU-983189" ]
[ "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-983189", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-6811434", "REACTOME:R-MMU-983189" ]
5
[ "7n61", "9ijj" ]
2
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3065 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 6, 10, 5, 8 ]
4
true
Domain
Kinesin-like protein KIF6/9, C-terminal
Kinesin-like protein KIF6/9, C-terminal
KIF6/9_C
5
IPR056525
56,525
HVO_1552, C-terminal
HVO_1552_C
Domain
485
false
false
This domain is found at the C-terminal of the predicted ArsR family transcription regulator HVO_1552 ( ) from Haloferax volcanii and similar archaeal sequences. It is predicted to adopt an α-helical structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24267" ]
[ "HVO_1552_C" ]
[ 485 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Stenosarchaea group", "hydrocarbon metagenome" ]
[ 484, 1 ]
2
[]
[]
0
true
Domain
HVO_1552, C-terminal
HVO_1552, C-terminal
HVO_1552_C
5
IPR056526
56,526
HVO_1752, TRASH domain
TRASH_HVO_1752
Domain
516
false
false
This TRASH domain is found at the C-terminal of the predicted Lrp/AsnC family transcription regulator HVO_1752 ( ) from Haloferax volcanii and similar archaeal proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24273" ]
[ "TRASH_HVO_1752_C" ]
[ 516 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[ "IPR011017" ]
[]
1
0
1
[ "Archaea", "Bacteria" ]
[ 506, 10 ]
2
[]
[]
0
true
Domain
HVO_1752, TRASH domain
HVO_1752, TRASH domain
TRASH_HVO_1752
8
IPR056527
56,527
E3 ubiquitin-protein ligase RFWD3-like, WD40 domain
WD40_RFWD3
Domain
2,678
false
false
This entry represents the WD40-repeat (WDR) domain of the E3 ubiquitin-protein ligase RFWD3, a protein required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage [ ]. This domain is responsible for the functional interactions that allow RFWD3 to maintain genomic stability [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF23419" ]
[ "WD40_RFWD3" ]
[ 2678 ]
1
[ "EC", "METACYC" ]
[ "2.3.2.27", "PWY-7511" ]
[ "EC:2.3.2.27", "METACYC:PWY-7511" ]
2
[ "6cvz" ]
1
[ "PUB00153391" ]
[ "33321094" ]
[ "The ubiquitin ligase RFWD3 is required for translesion DNA synthesis." ]
[ 2021 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2678 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 3, 2, 1, 2, 1, 8, 2, 24 ]
8
true
Domain
E3 ubiquitin-protein ligase RFWD3-like, WD40 domain
E3 ubiquitin-protein ligase RFWD3-like, WD40 domain
WD40_RFWD3
4
IPR056528
56,528
HVO_2833, C-terminal
HVO_2833_C
Domain
395
false
false
This is the C-terminal domain of the predicted ArsR family transcription regulator HVO_2833 ( ) from Haloferax volcanii. Its specific function is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24271" ]
[ "HVO_2833_C" ]
[ 395 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea" ]
[ 395 ]
1
[]
[]
0
true
Domain
HVO_2833, C-terminal
HVO_2833, C-terminal
HVO_2833_C
7
IPR056529
56,529
HVO_2928, N-terminal
HVO_2928_N
Domain
572
false
false
This domain is found at the N-terminal of the predicted transcription regulator HVO_2928 ( ) from Haloferax volcanii and similar proteins from Halobacteria. This domain is predicted to adopt an α-β structure. It is often found associated with .
[]
[]
[]
0
[ "PFAM" ]
[ "PF24281" ]
[ "HVO_2928_N" ]
[ 572 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Halobacteria" ]
[ 572 ]
1
[]
[]
0
true
Domain
HVO_2928, N-terminal
HVO_2928, N-terminal
HVO_2928_N
4
IPR056532
56,532
KIF21A/B, second helical domain
KIF21A/B_hel_2
Domain
5,472
false
false
This domain is found towards the C-terminal of human Kinesin-like protein KIF21A/B and similar eukaryotic sequences. KIF21A is a processive microtubule plus-end directed motor protein involved in neuronal axon guidance. It is recruited by KANK1 to cortical microtubule stabilising complexes (CMSCs) at focal adhesions (F...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23203" ]
[ "KIF21A" ]
[ 5472 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-6811434", "R-CEL-983189", "R-HSA-6811434", "R-HSA-983189", "R-MMU-2132295", "R-MMU-6811434", "R-MMU-983189", "R-RNO-2132295", "R-RNO-6811434", "R-RNO-983189" ]
[ "REACTOME:R-CEL-6811434", "REACTOME:R-CEL-983189", "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-983189", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-6811434", "REACTOME:R-MMU-983189", "REACTOME:R-RNO-2132295", "REACTOME:R-RNO-6811434", "REACTOME:R-RNO-983189" ]
10
[ "5d3a", "5nfd" ]
2
[ "PUB00155698", "PUB00158882", "PUB00158883" ]
[ "29183992", "36065637", "24120883" ]
[ "Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.", "Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex.", "CFEOM1-associated kinesin KIF21A is a cortical microtubule...
[ 2018, 2022, 2013 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "marine metagenome" ]
[ 2, 5469, 1 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 29, 3, 9, 9, 17 ]
6
true
Domain
KIF21A/B, second helical domain
KIF21A/B, second helical domain
KIF21A/B_hel_2
6
IPR056533
56,533
KIF21A/B, first helical domain
KIF21A/B_hel_1
Domain
5,652
false
false
This domain is found in human Kinesin-like protein KIF21A/B and similar eukaryotic sequences. KIF21A is a processive microtubule plus-end directed motor protein involved in neuronal axon guidance. It is recruited by KANK1 to cortical microtubule stabilising complexes (CMSCs) at focal adhesions (FAs) rims where it promo...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23204" ]
[ "KIF21A_2nd" ]
[ 5652 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-6811434", "R-CEL-983189", "R-HSA-6811434", "R-HSA-983189", "R-MMU-2132295", "R-MMU-6811434", "R-MMU-983189", "R-RNO-2132295", "R-RNO-6811434", "R-RNO-983189" ]
[ "REACTOME:R-CEL-6811434", "REACTOME:R-CEL-983189", "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-983189", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-6811434", "REACTOME:R-MMU-983189", "REACTOME:R-RNO-2132295", "REACTOME:R-RNO-6811434", "REACTOME:R-RNO-983189" ]
10
[]
0
[ "PUB00158883" ]
[ "24120883" ]
[ "CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor." ]
[ 2013 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 21, 5629, 2 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]
[ 1, 29, 3, 5, 8, 1, 17 ]
7
true
Domain
KIF21A/B, first helical domain
KIF21A/B, first helical domain
KIF21A/B_hel_1
9
IPR056534
56,534
NWD2, C-terminal beta-propeller domain
Beta-prop_NWD2_C
Domain
1,217
false
false
This entry represents the β-propeller domain found at the C-terminal of NACHT and WD repeat domain-containing protein 2 (NWD2) from human and similar proteins. The function of these proteins is not yet known.
[]
[]
[]
0
[ "PFAM" ]
[ "PF23586" ]
[ "Beta-prop_NWD2_C" ]
[ 1217 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 28, 1186, 3 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 4, 1, 1, 1, 3 ]
6
true
Domain
NWD2, C-terminal beta-propeller domain
NWD2, C-terminal beta-propeller domain
Beta-prop_NWD2_C
6
IPR056535
56,535
NUP160, middle TPR domain
TPR_NUP160_M
Domain
3,108
false
false
This entry represents a segment of TPRs found in the middle region of nucleoporin Nup160 from animal and plants, as well as in the homologues from fungi. NUP160 depletion could restore autophagy and inhibit fibrosis and inflammatory response in high glucose-treated [ ]. The Arabidopsis Nup160, a scaffold Nup, is import...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23354" ]
[ "TPR_NUP160_120_M" ]
[ 3108 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-DME-9615933", "R-HSA-1169408", "R-HSA-141444", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R...
[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-D...
69
[ "4ycz", "5a9q", "6lk8", "7fik", "7peq", "7r5j", "7r5k", "7tdz", "7vci", "7vop", "7wb4", "9hcj", "9sob" ]
13
[ "PUB00019951", "PUB00155767", "PUB00155872", "PUB00155873" ]
[ "11684705", "30910934", "34533106", "33367234" ]
[ "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.", "Mutations in <i>NUP160</i> Are Implicated in Steroid-Resistant Nephrotic Syndrome.", "Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.", "Nucleoporin 160 Regulates Flowering through Anch...
[ 2001, 2019, 2021, 2020 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3108 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 2, 2, 2, 4, 1, 1, 3, 22 ]
9
true
Domain
NUP160, middle TPR domain
NUP160, middle TPR domain
TPR_NUP160_M
8
IPR056536
56,536
NUP160, C-terminal TPR domain
TPR_NUP160_C
Domain
2,795
false
false
This entry represents the TPR-like repeats domain found in the C-terminal region of nucleoporin Nup160. The Arabidopsis Nup160, a scaffold Nup, is important for regulating the floral transition, a key developmental phase change in flowering plants, through modulating the subcellular localisation of HOS1 at NPCs [ ]. NU...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23347" ]
[ "TPR_Nup160_C" ]
[ 2795 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-DME-9615933", "R-HSA-1169408", "R-HSA-141444", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R...
[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-D...
69
[ "5a9q", "6lk8", "7fik", "7peq", "7r5j", "7r5k", "7tdz", "7vci", "7vop", "7wb4", "9hcj", "9sob" ]
12
[ "PUB00019951", "PUB00155767", "PUB00155872", "PUB00155873" ]
[ "11684705", "30910934", "34533106", "33367234" ]
[ "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.", "Mutations in <i>NUP160</i> Are Implicated in Steroid-Resistant Nephrotic Syndrome.", "Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.", "Nucleoporin 160 Regulates Flowering through Anch...
[ 2001, 2019, 2021, 2020 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2795 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 2, 3, 1, 4, 3, 17 ]
8
true
Domain
NUP160, C-terminal TPR domain
NUP160, C-terminal TPR domain
TPR_NUP160_C
7
IPR056538
56,538
ArlX
ArlX
Family
42
false
false
This entry represents ArlX (also known as FlaX), a component of the Sulfolobus motility machinery (archaellum) [ , ]. This protein is conserved in crenarchaeal archaella and forms ring-shaped oligomers. Its C-terminal region interacts with ArlI (FlaI), the archaellum motor ATPase that is involved in assembly and rotati...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24151" ]
[ "ArlX" ]
[ 42 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154540", "PUB00155628" ]
[ "24103130", "23129770" ]
[ "Insights into subunit interactions in the Sulfolobus acidocaldarius archaellum cytoplasmic complex.", "FlaX, a unique component of the crenarchaeal archaellum, forms oligomeric ring-shaped structures and interacts with the motor ATPase FlaI." ]
[ 2013, 2012 ]
2
[]
[]
0
0
null
[ "Thermoproteati" ]
[ 42 ]
1
[]
[]
0
true
Family
ArlX
ArlX
ArlX
1
IPR056539
56,539
NuiA-like
NuiA-like
Family
1,018
false
false
This entry represents a group of fungal proteins that are related to the nuclease A inhibitor NuiA ( ). NuiA is known to regulate the activity of NucA, one of the most potent nucleases involved in degradation of both single- and double-stranded DNA and RNA. The NucA inhibition by NuiA involves an unusual divalent metal...
[]
[]
[]
0
[ "PFAM", "PANTHER" ]
[ "PF23151", "PTHR42093" ]
[ "NuiA_2", "" ]
[ 1017, 916 ]
2
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Fungi" ]
[ 1018 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 2, 1 ]
2
true
Family
NuiA-like
NuiA-like
NuiA-like
7
IPR056540
56,540
Nucleoporin POM152, N-terminal transmembrane domain
TMD_POM152
Domain
1,642
false
false
This domain is found at the N-terminal of Nucleoporin POM152 from Saccharomyces cerevisiae and similar fungal proteins. POM152 functions as a component of the nuclear pore complex (NPC) [ ]. This protein consists of an N-terminal transmembrane domain (TMD) and an extended C-terminal domain (CTD) with tandem repeats of ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24097" ]
[ "TMD_POM152" ]
[ 1642 ]
1
[]
[]
[]
0
[ "8t9l" ]
1
[ "PUB00087493", "PUB00155865" ]
[ "8682855", "37738963" ]
[ "The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.", "Implications of a multiscale structure of the yeast nuclear pore complex." ]
[ 1996, 2023 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1642 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
Nucleoporin POM152, N-terminal transmembrane domain
Nucleoporin POM152, N-terminal transmembrane domain
TMD_POM152
2
IPR056541
56,541
Nucleoporin POM152, Ig-like domain
Ig-like_POM152
Domain
1,799
false
false
This entry includes the third and sixth Ig-like domains found in Nucleoporin POM152 from yeast, a component of the nuclear pore complex (NPC) [ ]. POM152 functions as a component of the nuclear pore complex (NPC) [ ]. This protein consists of an N-terminal transmembrane domain (TMD) and an extended C-terminal domain (C...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24312" ]
[ "Ig-like_POM152" ]
[ 1799 ]
1
[]
[]
[]
0
[ "5tvz", "8t9l" ]
2
[ "PUB00087493", "PUB00087494", "PUB00155865" ]
[ "8682855", "11352933", "37738963" ]
[ "The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.", "A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.", "Implications of a multiscale structure of the yeast nuclear pore complex." ]
[ 1996, 2001, 2023 ]
3
[]
[]
0
0
null
[ "Bacteroidota", "Eukaryota" ]
[ 54, 1745 ]
2
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
Nucleoporin POM152, Ig-like domain
Nucleoporin POM152, Ig-like domain
Ig-like_POM152
2
IPR056542
56,542
Nucleoporin POM152, first Ig-like domain
Ig-like_POM152_1st
Domain
1,695
false
false
This is the first immunoglobulin-like (Ig-like) domain found in Nucleoporin POM152 from yeast and similar fungal proteins. POM152 functions as a component of the nuclear pore complex (NPC) [ ]. This protein consists of an N-terminal transmembrane domain (TMD) and an extended C-terminal domain (CTD) with tandem repeats ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24519" ]
[ "Ig-like_Pom152_1" ]
[ 1695 ]
1
[]
[]
[]
0
[ "8t9l" ]
1
[ "PUB00087493", "PUB00155865" ]
[ "8682855", "37738963" ]
[ "The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.", "Implications of a multiscale structure of the yeast nuclear pore complex." ]
[ 1996, 2023 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1695 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
Nucleoporin POM152, first Ig-like domain
Nucleoporin POM152, first Ig-like domain
Ig-like_POM152_1st
4
IPR056543
56,543
Nucleoporin POM152, ninth Ig-like domain
Ig-like_POM152_9th
Domain
1,713
false
false
This domain is found in Nucleoporin POM152 from yeast and similar fungal proteins. This domain is predicted to adopt an immunoglobulin-like structure and it is the ninth in the tandem. POM152 functions as a component of the nuclear pore complex (NPC) [ ]. This protein consists of an N-terminal transmembrane domain (TMD...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24527" ]
[ "Ig-like_Pom152_9" ]
[ 1713 ]
1
[]
[]
[]
0
[ "8t9l" ]
1
[ "PUB00087493", "PUB00155865" ]
[ "8682855", "37738963" ]
[ "The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.", "Implications of a multiscale structure of the yeast nuclear pore complex." ]
[ 1996, 2023 ]
2
[]
[]
0
0
null
[ "Eukaryota", "Lishizhenia tianjinensis" ]
[ 1712, 1 ]
2
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
Nucleoporin POM152, ninth Ig-like domain
Nucleoporin POM152, ninth Ig-like domain
Ig-like_POM152_9th
1
IPR056544
56,544
Nucleoporin POM152, immunoglobulin-like domain
Ig_POM152
Domain
1,738
false
false
This domain is found in Nucleoporin POM152 from Schizosaccharomyces pombe and similar fungal proteins. This domain is predicted to adopt an immunoglobulin-like structure. POM152 functions as a component of the nuclear pore complex (NPC) [ ]. This protein consists of an N-terminal transmembrane domain (TMD) and an exten...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23664" ]
[ "Ig_Pom152" ]
[ 1738 ]
1
[]
[]
[]
0
[ "8t9l" ]
1
[ "PUB00087493", "PUB00155865" ]
[ "8682855", "37738963" ]
[ "The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.", "Implications of a multiscale structure of the yeast nuclear pore complex." ]
[ 1996, 2023 ]
2
[]
[]
0
0
null
[ "Capnocytophaga", "Eukaryota" ]
[ 5, 1733 ]
2
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
Nucleoporin POM152, immunoglobulin-like domain
Nucleoporin POM152, immunoglobulin-like domain
Ig_POM152
7
IPR056546
56,546
MreB/MamK-like
MreB_MamK-like
Family
28,903
false
false
This entry consists of bacterial MreB and MreB-like (Mbl) proteins and the related MamK proteins [ , ]. MreB forms membrane-associated dynamic filaments that are essential for cell shape determination [ , , ]. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated t...
[]
[]
[]
0
[ "PFAM" ]
[ "PF06723" ]
[ "MreB_Mbl" ]
[ 28903 ]
1
[]
[]
[]
0
[ "1jce", "1jcf", "1jcg", "2wus", "4cze", "4czf", "4czg", "4czh", "4czi", "4czj", "4czk", "4czl", "4czm", "5jyg", "5ljv", "5ljw", "7bvy", "7bvz", "7e1c", "7e1g", "7zpt", "7zpu", "8aam", "8ab4", "8azg", "8r2n" ]
26
[ "PUB00012806", "PUB00106098", "PUB00106099", "PUB00127202", "PUB00158677", "PUB00158680", "PUB00158681", "PUB00158893", "PUB00158894" ]
[ "12758091", "21883528", "27391173", "21903929", "28790202", "24957623", "23204522", "15612918", "24550515" ]
[ "Cytoskeletons in prokaryotes.", "MamK, a bacterial actin, forms dynamic filaments in vivo that are regulated by the acidic proteins MamJ and LimJ.", "Structure of the magnetosome-associated actin-like MamK filament at subnanometer resolution.", "The bacterial actin MreB rotates, and rotation depends on cell-...
[ 2003, 2011, 2017, 2011, 2017, 2014, 2013, 2005, 2014 ]
9
[]
[ "IPR004753" ]
0
1
0
[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctgu013", "unclassified sequences" ]
[ 81, 27884, 152, 1, 785 ]
5
[ "Escherichia coli (strain K12)", "Homo sapiens" ]
[ 1, 1 ]
2
true
Family
MreB/MamK-like
MreB/MamK-like
MreB_MamK-like
6
IPR056547
56,547
NUP160, helical domain
NUP160_helical
Domain
1,673
false
false
This entry represents the central helical domain of NUP160, from animals. NUP160 is one of up to 60 proteins that constitute the Nuclear Pore Complex (NPC) as a component of the NUP107-160 subcomplex [ ]. NUP160, in conjunction with NUP133, interacts with NUP98 and NUP153, mediating mRNA export [ ]. NUP160 depletion co...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23345" ]
[ "NUP160_helical" ]
[ 1673 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-DME-9615933", "R-HSA-1169408", "R-HSA-141444", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R...
[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-D...
69
[ "5a9q", "6lk8", "7fik", "7peq", "7r5j", "7r5k", "7tdz", "7vci", "7vop", "7wb4", "9hcj" ]
11
[ "PUB00019951", "PUB00155767", "PUB00155872" ]
[ "11684705", "30910934", "34533106" ]
[ "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.", "Mutations in <i>NUP160</i> Are Implicated in Steroid-Resistant Nephrotic Syndrome.", "Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy." ]
[ 2001, 2019, 2021 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1673 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 2, 4, 1, 3 ]
5
true
Domain
NUP160, helical domain
NUP160, helical domain
NUP160_helical
5
IPR056548
56,548
Nucleoporin nup120-like, HEAT repeat domain, fungal
HEAT_Nup120
Domain
1,379
false
false
These HEAT repeats form an elongated α-helical stack at the C-terminal end of Nucleoporin nup120 from Schizosaccharomyces pombe and similar sequences mainly from fungi. Nup120 functions as a component of the nuclear pore complex (NPC). Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup16...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23300" ]
[ "HEAT_Nup120" ]
[ 1379 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-SCE-159236", "R-SCE-170822", "R-SCE-3371453", "R-SCE-4085377", "R-SCE-4551638", "R-SCE-4570464", "R-SPO-159227", "R-SPO-159231", "R-SPO-159236", "R-SPO-170822", "R-SPO-3371453", "R-SPO-4085377", "R-SPO-4551638", "R-SPO-4570464", "R-SPO-5578749", "R-SPO-9615933" ]
[ "REACTOME:R-SCE-159236", "REACTOME:R-SCE-170822", "REACTOME:R-SCE-3371453", "REACTOME:R-SCE-4085377", "REACTOME:R-SCE-4551638", "REACTOME:R-SCE-4570464", "REACTOME:R-SPO-159227", "REACTOME:R-SPO-159231", "REACTOME:R-SPO-159236", "REACTOME:R-SPO-170822", "REACTOME:R-SPO-3371453", "REACTOME:R-SP...
16
[ "4fhm", "4fhn", "4gq2", "4xmm", "4xmn", "7n84", "7n9f", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "8tie" ]
13
[ "PUB00019951", "PUB00053539", "PUB00062495" ]
[ "11684705", "8557736", "22955883" ]
[ "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.", "Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport.", "Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex." ]
[ 2001, 1995, 2012 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]
[ 14, 1364, 1 ]
3
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]
[ 1, 1, 1, 1 ]
4
true
Domain
Nucleoporin nup120-like, HEAT repeat domain, fungal
Nucleoporin nup120-like, HEAT repeat domain, fungal
HEAT_Nup120
8
IPR056549
56,549
Nucleolar protein 4, helical domain
HTH_NOL4
Domain
3,052
false
false
This domain is found in human Nucleolar protein 4 (NOL4), Nucleolar protein 4-like (NOL4L) and similar animal sequences. This domain is predicted to form an α-helical bundle. NOL4 has been identified as a methylation target for cervical [ ] and head and neck cancer [ ]. NOL4L was first identified in acute myeloid leuka...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23079" ]
[ "HTH_NOL4_2nd" ]
[ 3052 ]
1
[]
[]
[]
0
[]
0
[ "PUB00083195", "PUB00083196", "PUB00158895", "PUB00158896", "PUB00158897" ]
[ "18381458", "24337411", "33940382", "20520637", "31645055" ]
[ "Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning.", "Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.", "NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI...
[ 2008, 2014, 2021, 2010, 2020 ]
5
[]
[]
0
0
null
[ "Metazoa" ]
[ 3052 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 16, 3, 8, 12, 12 ]
5
true
Domain
Nucleolar protein 4, helical domain
Nucleolar protein 4, helical domain
HTH_NOL4
7
IPR056550
56,550
Nucleolar protein 10-like, second domain
NOL10_2nd
Domain
4,690
false
false
This domain is found in human Nucleolar protein 10 (NOL10) and similar eukaryotic sequences including the orthologue from yeast, Ribosome biogenesis protein (ENP2). This domain is normally found N-terminal to . It is predicted to adopt an α-β configuration. NOL10 (also known as Polyglutamine binding protein 5 (PQBP5)) ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23097" ]
[ "NOL10_2nd" ]
[ 4690 ]
1
[]
[]
[]
0
[ "5wlc", "6ke6", "6lqp", "6lqq", "6lqr", "6lqu", "6lqv", "6rxu", "6rxv", "6rxx", "6rxz", "6zqb", "6zqc", "7ajt", "7d63", "7mq8", "7mq9", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z", "9n70", "9n72", "9n73" ]
26
[ "PUB00075792", "PUB00158898" ]
[ "16544271", "36599853" ]
[ "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes.", "PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions." ]
[ 2006, 2023 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4690 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 4, 1, 2, 1, 7, 4, 1, 4, 4, 1, 1, 9 ]
12
true
Domain
Nucleolar protein 10-like, second domain
Nucleolar protein 10-like, second domain
NOL10_2nd
8
IPR056551
56,551
Nucleolar protein 10-like, N-terminal domain
Beta-prop_NOL10_N
Domain
28,095
false
false
This domain is found at the N-terminal of human Nucleolar protein 10 (NOL10) and similar eukaryotic sequences including the orthologue from yeast Ribosome biogenesis protein (ENP2). This domain is normally found N-terminal to . This entry includes a entire β-propeller structure and two α-helices. NOL10 (also known as P...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23098" ]
[ "Beta-prop_NOL10_N" ]
[ 28095 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-BTA-168638", "R-BTA-177929", "R-BTA-2173788", "R-BTA-428930", "R-CFA-168638", "R-CFA-177929", "R-CFA-428930", "R-DDI-5674135", "R-DDI-6781823", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-72163", "R-DRE-1632852", "R-DRE-165159", "R-DRE-166208", "R-DRE-380972", "R-DRE-5628897", "R-D...
[ "REACTOME:R-BTA-168638", "REACTOME:R-BTA-177929", "REACTOME:R-BTA-2173788", "REACTOME:R-BTA-428930", "REACTOME:R-CFA-168638", "REACTOME:R-CFA-177929", "REACTOME:R-CFA-428930", "REACTOME:R-DDI-5674135", "REACTOME:R-DDI-6781823", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DD...
70
[ "3jb9", "3jcr", "5gm6", "5gmk", "5hqg", "5igq", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5o9z", "5wlc", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "6ah0", "6ahd", "6bk8", "6exn", "6ff7", "6g6m", "6g6n", "6icz", "6id0", "6id1"...
131
[ "PUB00075792", "PUB00158898" ]
[ "16544271", "36599853" ]
[ "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes.", "PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions." ]
[ 2006, 2023 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Megavirus", "metagenomes" ]
[ 323, 27763, 3, 6 ]
4
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 48, 5, 27, 5, 32, 23, 4, 20, 34, 3, 4, 73 ]
12
true
Domain
Nucleolar protein 10-like, N-terminal domain
Nucleolar protein 10-like, N-terminal domain
Beta-prop_NOL10_N
1
IPR056553
56,553
Mug60/KHD4, KH type I domain
KH_Mug60-KHD4
Domain
1,673
false
false
This is a type I KH domain found in Meiotically up-regulated gene 60 protein (Mug60) from Schizosaccharomyces pombe and KHD4 from Ustilago maydis. KHD4 is a RNA-binding protein that recognises the sequence AUACCC [ ]. It plays an essential role in filamentous growth and virulence [ ]. Mug60 plays a role in meiosis [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24563" ]
[ "KH_Mug60-KHD4" ]
[ 1673 ]
1
[]
[]
[]
0
[]
0
[ "PUB00044889", "PUB00114345", "PUB00155693" ]
[ "16303567", "15643068", "19854870" ]
[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "Role for RNA-binding proteins implicated in pathogenic development of Ustilago maydis.", "Tandem KH domains of Khd4 recognize AUACCC and are essential for regulation of morphology as well as pathogenicity in ...
[ 2005, 2005, 2009 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1673 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1 ]
2
true
Domain
Mug60/KHD4, KH type I domain
Mug60/KHD4, KH type I domain
KH_Mug60-KHD4
3
IPR056555
56,555
NFD4, C-terminal domain
NFD4_C
Domain
10,277
false
false
This domain is found at the C-terminal of Protein NUCLEAR FUSION DEFECTIVE 4 from Arabidopsis thaliana (NFD4) and similar sequences predominantly found in plants. NFD4 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus [ ]. This prote...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23262" ]
[ "NFD4_C" ]
[ 10277 ]
1
[]
[]
[]
0
[]
0
[ "PUB00078265" ]
[ "16698901" ]
[ "NUCLEAR FUSION DEFECTIVE1 encodes the Arabidopsis RPL21M protein and is required for karyogamy during female gametophyte development and fertilization." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 10277 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 86, 57, 98 ]
3
true
Domain
NFD4, C-terminal domain
NFD4, C-terminal domain
NFD4_C
8
IPR056556
56,556
Lysophospholipase NTE1-like, P-loop domain
NTE1_P-loop_dom
Domain
7,565
false
false
This domain is found in a variety of phospholipases such as Lysophospholipase NTE1, Neuropathy target esterase sws and related proteins. This domain appears to be structurally related to P-loop ATPases, but it appears to not contain the typical APT-binding motifs. Sws is an intracellular phospholipase B that catalyses ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24179" ]
[ "NTE_Ploop" ]
[ 7565 ]
1
[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "3.1.1.5", "PWY-7409", "R-CEL-6814848", "R-DME-6814848", "R-HSA-6814848", "R-MMU-6814848", "R-SCE-6814848", "R-SPO-6814848" ]
[ "EC:3.1.1.5", "METACYC:PWY-7409", "REACTOME:R-CEL-6814848", "REACTOME:R-DME-6814848", "REACTOME:R-HSA-6814848", "REACTOME:R-MMU-6814848", "REACTOME:R-SCE-6814848", "REACTOME:R-SPO-6814848" ]
8
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 629, 6928, 8 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...
[ 2, 12, 2, 6, 4, 1, 11, 1, 1 ]
9
true
Domain
Lysophospholipase NTE1-like, P-loop domain
Lysophospholipase NTE1-like, P-loop domain
NTE1_P-loop_dom
7
IPR056558
56,558
LAMB1/2/3/4, helical domain
LAMB1-4_helical
Domain
3,913
false
false
This domain is found in human Laminin subunit beta-1/2/3/4 (LAMB1-4) and related proteins from animals. LAMB1 is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components [ ]. This domain, which is located C...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23219" ]
[ "LAMB1" ]
[ 3913 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-1474228", "R-HSA-2022090", "R-HSA-2214320", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-373760", "R-HSA-381426", "R-HSA-446107", "R-HSA-8874081", "R-HSA-8957275", "R-HSA-9619665", "R-HSA-9638630", "R-HSA-9913351", "R-HSA-9925563" ]
[ "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-2214320", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-373760", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-446107", "REACTOME:R-HSA-8874081", "REACTOME:R-HSA-8957275", "REACTOME:R...
15
[]
0
[ "PUB00147825", "PUB00147828", "PUB00155704" ]
[ "28879238", "23472759", "36658135" ]
[ "Mechanistic basis for the recognition of laminin-511 by α6β1 integrin.", "Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.", "Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies." ]
[ 2017, 2013, 2023 ]
3
[]
[]
0
0
null
[ "Eukaryota", "Kangiella spongicola" ]
[ 3912, 1 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 10, 14, 10, 11 ]
4
true
Domain
LAMB1/2/3/4, helical domain
LAMB1/2/3/4, helical domain
LAMB1-4_helical
9
IPR056559
56,559
Nodulin homeobox, C-terminal domain
NDX_C
Domain
768
false
false
This domain is found at the C-terminal of NDX, and it has a detectable partial sequence similarity to PUA domains but it is predicted to adopt a β-barrel with SH3 topology. This entry represents a group of plant proteins, including nodulin homeobox protein (NDX) from Arabidopsis. AtNDX associates with single-stranded D...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24679" ]
[ "Nodulin_C" ]
[ 768 ]
1
[]
[]
[]
0
[]
0
[ "PUB00089445", "PUB00158907" ]
[ "23641115", "36030240" ]
[ "R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.", "NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis." ]
[ 2013, 2022 ]
2
[]
[]
0
0
null
[ "Embryophyta" ]
[ 768 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 7, 3, 32 ]
3
true
Domain
Nodulin homeobox, C-terminal domain
Nodulin homeobox, C-terminal domain
NDX_C
2
IPR056560
56,560
Nodulin homeobox, homeobox-like domain
HTH_NDX
Domain
896
false
false
This domain is found towards the C-terminal of NDX. It has a detectable sequence similarity to known homeobox domains, and it is predicted to adopt similar structure. This entry represents a group of plant proteins, including nodulin homeobox protein (NDX) from Arabidopsis. AtNDX associates with single-stranded DNA and...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24426" ]
[ "HTH_NDX" ]
[ 896 ]
1
[]
[]
[]
0
[]
0
[ "PUB00089445", "PUB00158907" ]
[ "23641115", "36030240" ]
[ "R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.", "NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis." ]
[ 2013, 2022 ]
2
[ "IPR001356" ]
[]
1
0
1
[ "Streptophytina" ]
[ 896 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 8, 4, 41 ]
3
true
Domain
Nodulin homeobox, homeobox-like domain
Nodulin homeobox, homeobox-like domain
HTH_NDX
2
IPR056561
56,561
NFP/LYK4/5, first LysM domain
NFP_LYK_LysM1
Domain
3,442
false
false
This entry represents the first LysM domain found in proteins from plants, including the NFP from Medicago truncatula and LYK4/5 from Arabidopsis thaliana. The LysM domain adopt a β-α-α-β fold [ ]. NFP/NFR5 class of receptors are crucial for initial lipochitooligosaccharide (LCO) perception and essential for LCO-mediat...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23446" ]
[ "LysM1_NFP_LYK" ]
[ 3442 ]
1
[]
[]
[]
0
[ "7au7", "7bax", "9gxf", "9gxz", "9h39", "9h3a", "9q83", "9q84" ]
8
[ "PUB00001727", "PUB00019876", "PUB00082420", "PUB00155726", "PUB00155727", "PUB00155728", "PUB00155730" ]
[ "1352512", "10369758", "15120137", "34716271", "31969929", "32764065", "22087221" ]
[ "Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin.", "Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.", "Specific recognition of bacteria by plant LysM domain receptor kinases.", "Kinetic proofreading of ...
[ 1992, 1999, 2004, 2021, 2020, 2020, 2011 ]
7
[]
[]
0
0
null
[ "Streptophytina" ]
[ 3442 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 8, 11, 37 ]
3
true
Domain
NFP/LYK4/5, first LysM domain
NFP/LYK4/5, first LysM domain
NFP_LYK_LysM1
6
IPR056562
56,562
LYK3/4/5, second LysM domain
LysM2_CERK1_LYK3_4_5
Domain
3,049
false
false
This entry represents the second LysM domain found in proteins from plants, including LYK3 from Medicago truncatula, CERK1 and LYK4/5 from Arabidopsis thaliana. The LysM domain adopt a β-α-α-β fold. Arabidopsis thaliana has retained the root developmental response to chitin-derived signals, utilising a widely conserved...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23472" ]
[ "LysM2_CERK1_LYK3_4_5" ]
[ 3049 ]
1
[ "EC" ]
[ "2.7.11.1" ]
[ "EC:2.7.11.1" ]
1
[ "4eby", "4ebz", "6xwe", "9gxf", "9gxz", "9h24", "9h39", "9h3a", "9q83", "9q84" ]
10
[ "PUB00155726", "PUB00155727", "PUB00155728", "PUB00155729" ]
[ "34716271", "31969929", "32764065", "36115339" ]
[ "Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors.", "A method for functional testing constitutive and ligand-induced interactions of lysin motif receptor proteins.", "Ligand-recognizing motifs in plant LysM receptors are major determinants of specifici...
[ 2021, 2020, 2020, 2022 ]
4
[]
[]
0
0
null
[ "Embryophyta" ]
[ 3049 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 11, 8, 8 ]
3
true
Domain
LYK3/4/5, second LysM domain
LYK3/4/5, second LysM domain
LysM2_CERK1_LYK3_4_5
2
IPR056564
56,564
KY-like, immunoglobulin-like domain
Ig-like_KY
Domain
3,759
false
false
This domain is found in tandem in human Kyphoscoliosis peptidase (KY), a probable cytoskeleton-associated protease required for normal muscle growth [ ]. This domain is predicted to adopt an immunoglobulin-like structure. Proteins containing this domain are mainly found in animals. This domain is also found in tandem i...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23265" ]
[ "Ig-like_KY" ]
[ 3759 ]
1
[]
[]
[]
0
[]
0
[ "PUB00158908" ]
[ "11136708" ]
[ "The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein." ]
[ 2001 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanotrichaceae", "marine metagenome" ]
[ 75, 3679, 4, 1 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 1, 1, 1, 2, 3 ]
6
true
Domain
KY-like, immunoglobulin-like domain
KY-like, immunoglobulin-like domain
Ig-like_KY
5
IPR056565
56,565
Activating transcription factor 7-interacting protein, Fn3 domain
Fn3_ATF7IP
Domain
2,387
false
false
This entry represents the Fibronectin type III (Fn3) domain found in Activating transcription factor 7-interacting protein (MCAF) family of proteins. Activating transcription factor 7-interacting protein (MCAF) family consists of MCAF1 and MCAF2 [ ]. MCAF1 (also known as MBD1-containing chromatin-associated factor 1) i...
[]
[]
[]
0
[ "PFAM" ]
[ "PF16794" ]
[ "fn3_4" ]
[ 2387 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DRE-3214841", "R-DRE-9843940", "R-DRE-9843970", "R-HSA-3214841", "R-HSA-9843940", "R-HSA-9843970", "R-MMU-3214841", "R-MMU-9843940" ]
[ "REACTOME:R-DRE-3214841", "REACTOME:R-DRE-9843940", "REACTOME:R-DRE-9843970", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-9843940", "REACTOME:R-HSA-9843970", "REACTOME:R-MMU-3214841", "REACTOME:R-MMU-9843940" ]
8
[]
0
[ "PUB00058087", "PUB00059977", "PUB00059983" ]
[ "14536086", "10777215", "15691849" ]
[ "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.", "A murine ATFa-associated factor with transcriptional repressing activity.", "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins." ]
[ 2003, 2000, 2005 ]
3
[ "IPR003961" ]
[]
1
0
1
[ "Metazoa" ]
[ 2387 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 24, 1, 5, 2, 7 ]
5
true
Domain
Activating transcription factor 7-interacting protein, Fn3 domain
Activating transcription factor 7-interacting protein, Fn3 domain
Fn3_ATF7IP
3
IPR056566
56,566
CPBP family lipoprotein N-acylation protein LnsB-like
Acyl_LnsB_CPBP-like
Family
61
false
false
This family includes LnsB and related bacterial proteins from the CPBP family. LnsB is involved in a two-protein system for the N-acylation of lipoproteins. It belongs to the CPBP family of Rce1-like glutamic-type intramembrane proteases, which includes the type II CAAX prenyl proteases in eukaryotes and the myxosortas...
[]
[]
[]
0
[ "NCBIFAM" ]
[ "NF041768" ]
[ "acyl_LnsB_CPBP" ]
[ 61 ]
1
[]
[]
[]
0
[]
0
[ "PUB00152898" ]
[ "32723923" ]
[ "Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Bacillales", "human gut metagenome" ]
[ 60, 1 ]
2
[]
[]
0
true
Family
CPBP family lipoprotein N-acylation protein LnsB-like
CPBP family lipoprotein N-acylation protein LnsB-like
Acyl_LnsB_CPBP-like
3
IPR056567
56,567
Lipoprotein N-acylation protein LnsA-like
Acyl_LnsA-like
Family
55
false
false
This family includes LnsA and related bacterial proteins. Together with LnsB, LnsA is involved in a two-protein system for the N-acylation of lipoproteins. LnsA shows some similarity with the NlpC/P60 superfamily [ ].
[]
[]
[]
0
[ "NCBIFAM" ]
[ "NF041769" ]
[ "acyl_LnsA" ]
[ 55 ]
1
[]
[]
[]
0
[]
0
[ "PUB00152898" ]
[ "32723923" ]
[ "Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Bacillales" ]
[ 55 ]
1
[]
[]
0
true
Family
Lipoprotein N-acylation protein LnsA-like
Lipoprotein N-acylation protein LnsA-like
Acyl_LnsA-like
8
IPR056568
56,568
Flagellar accessory protein ArlH
ArlH
Family
29
false
false
Flagellar accessory protein ArlH (also known as FlaH) is part of the motor of the archaellum membrane-anchored archaeal motility structure, together with ArlX and ArlI. ArlH forms a hexameric ring, and binds ATP, which is essential for its interaction with ArlI and for archaellum assembly [ , , ]. The C-terminal region...
[]
[]
[]
0
[ "CDD" ]
[ "cd19475" ]
[ "FlaH" ]
[ 29 ]
1
[]
[]
[]
0
[ "4wia" ]
1
[ "PUB00010517", "PUB00110063", "PUB00153718", "PUB00154540", "PUB00158983", "PUB00158984" ]
[ "11250034", "9115177", "26508112", "24103130", "34219289", "29938130" ]
[ "The archaeal flagellum: a different kind of prokaryotic motility structure.", "Evolutionary comparisons of RecA-like proteins across all major kingdoms of living organisms.", "The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor.", "Insights int...
[ 2001, 1997, 2016, 2013, 2021, 2018 ]
6
[]
[]
0
0
null
[ "Archaea" ]
[ 29 ]
1
[]
[]
0
true
Family
Flagellar accessory protein ArlH
Flagellar accessory protein ArlH
ArlH
6
IPR056569
56,569
Flagella accessory protein J-like
FlaJ-like
Family
2,771
false
false
This family includes FlaJ from Methanocaldococcus jannaschii, ArlJ from Halobacterium salinarum ( ) and related prokaryotic proteins that are involved in the formation and function of flagella, which are whip-like structures that enable motility in various types of cells. They are accessory components that may interact...
[]
[]
[]
0
[ "PANTHER" ]
[ "PTHR35402" ]
[ "" ]
[ 2771 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "unclassified sequences" ]
[ 2699, 7, 65 ]
3
[]
[]
0
true
Family
Flagella accessory protein J-like
Flagella accessory protein J-like
FlaJ-like
4
IPR056570
56,570
PilB3-like, N-terminal
PilB3-like_N
Domain
918
false
false
This domain is found at the N-terminal of PilB3 from Haloferax volcanii and similar archaeal proteins. This domain is found associated with and . PilB3 is involved in the biosynthesis and assembly of type IV pili, which are filamentous protein structures on the cell surface that play various roles in cellular processes...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23990" ]
[ "PilB3_N" ]
[ 918 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155799", "PUB00158990" ]
[ "31068907", "24945931" ]
[ "Limited Cross-Complementation Between <i>Haloferax volcanii</i> PilB1-C1 and PilB3-C3 Paralogs.", "A conserved type IV pilin signal peptide H-domain is critical for the post-translational regulation of flagella-dependent motility." ]
[ 2019, 2014 ]
2
[]
[]
0
0
null
[ "Archaea", "ecological metagenomes" ]
[ 914, 4 ]
2
[]
[]
0
true
Domain
PilB3-like, N-terminal
PilB3-like, N-terminal
PilB3-like_N
8
IPR056572
56,572
PaaD, zinc beta ribbon domain
Zn_ribbon_PaaD
Domain
7,052
false
false
This domain is found in PaaD from Escherichia coli and similar sequences from bacteria and some archaeal proteins. This domain is predicted to adopt a zinc β-ribbon fold and contains two invariant CxxC sequence motifs. In addition, towards the C-terminal it has a semi-conserved [EQ]PF[DEQ] sequence motif [ ]. PaaD from...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23451" ]
[ "Zn_ribbon_PaaD" ]
[ 7052 ]
1
[]
[]
[]
0
[]
0
[ "PUB00153012" ]
[ "16997993" ]
[ "Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli." ]
[ 2006 ]
1
[]
[]
0
0
null
[ "Bacteria", "Halobacteriales", "Opisthokonta", "unclassified sequences" ]
[ 6844, 155, 5, 48 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
PaaD, zinc beta ribbon domain
PaaD, zinc beta ribbon domain
Zn_ribbon_PaaD
2
IPR056573
56,573
Legume lectins, beta-barrel domain
Lectin_L-type_dom
Domain
1,699
false
false
The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind [ ]. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-a...
[]
[]
[]
0
[ "CDD" ]
[ "cd01951" ]
[ "lectin_L-type" ]
[ 1699 ]
1
[]
[]
[]
0
[ "4m00", "4m01", "7elv", "7exo", "7yl4", "7yl5", "7yl6" ]
7
[ "PUB00039168", "PUB00057389", "PUB00080230", "PUB00085830", "PUB00114123", "PUB00115238", "PUB00115239", "PUB00115240", "PUB00115241", "PUB00115246" ]
[ "16439369", "3965973", "14533788", "18025080", "17709241", "12223270", "12376725", "12381156", "14533791", "14630957" ]
[ "Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p.", "Polypeptide ligation occurs during post-translational modification of concanavalin A.", "Classification of plant lectins in families of structurally and evolutionary related proteins.", "Molecular basi...
[ 2006, 1985, 2001, 2008, 2007, 2002, 2001, 2002, 2001, 2003 ]
10
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]
[ 1351, 334, 6, 8 ]
4
[]
[]
0
true
Domain
Legume lectins, beta-barrel domain
Legume lectins, beta-barrel domain
Lectin_L-type_dom
1
IPR056575
56,575
MCM3-like, winged helix domain
WH_MCM3_C
Domain
4,244
false
false
This small C-terminal winged helix (WH) domain is found in the human DNA replication licensing factor MCM3 and similar eukaryotic sequences. MCM3 is a minichromosome maintenance (MCM) protein, a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA repli...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23191" ]
[ "WHD_MCM3_C" ]
[ 4244 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "3.6.4.12", "R-BTA-176187", "R-BTA-68867", "R-BTA-68949", "R-BTA-68962", "R-BTA-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-MMU-176187", "R-MMU-6...
[ "EC:3.6.4.12", "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68867", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-BTA-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:...
35
[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6wgc", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo", "7plo"...
83
[ "PUB00154055" ]
[ "32453425" ]
[ "CryoEM structures of human CMG-ATPγS-DNA and CMG-AND-1 complexes." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 4244 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 6, 1, 3, 2, 8, 4, 1, 2, 3, 1, 1, 16 ]
12
true
Domain
MCM3-like, winged helix domain
MCM3-like, winged helix domain
WH_MCM3_C
9
IPR056577
56,577
Gp84-like
Phage_Gp84
Domain
71
false
false
This entry represents a domain found in phage proteins, including the Gp84 protein from Mycobacteriophage L5 ( ). An AlphaFold model of a member ( ) has a compact fold of one α-helix followed by a three stranded β-sheet. The function of these proteins is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF23794" ]
[ "Phage_Gp84" ]
[ 71 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes" ]
[ 3, 68 ]
2
[]
[]
0
true
Domain
Gp84-like
Gp84-like
Phage_Gp84
3
IPR056578
56,578
N4BP1, C-terminal UBA domain
UBA_N4BP1_C
Domain
1,496
false
false
This domain is found in the N4BP1 family which includes NEDD4-binding protein 1, KHNYN and other related proteins. This domain has a significant sequence and structural similarity to known UBA domains. It was shown that in KHNYN, this domain is responsible for binding ubiquitin-like protein NEDD8 ( ). In N4BP1, this do...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23054" ]
[ "UBA_N4BP1_C" ]
[ 1496 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DRE-9758274", "R-HSA-9758274", "R-MMU-9758274", "R-XTR-9758274" ]
[ "REACTOME:R-DRE-9758274", "REACTOME:R-HSA-9758274", "REACTOME:R-MMU-9758274", "REACTOME:R-XTR-9758274" ]
4
[ "2n5m", "2n7k", "8t48", "9bgl" ]
4
[ "PUB00101187", "PUB00158996", "PUB00159024" ]
[ "31133753", "38697117", "32971525" ]
[ "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.", "N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.", "Integration of innate immune signalling by caspase-8 cleavage of N4BP1." ]
[ 2019, 2024, 2020 ]
3
[]
[]
0
0
null
[ "Eumetazoa" ]
[ 1496 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 5, 5, 6 ]
4
true
Domain
N4BP1, C-terminal UBA domain
N4BP1, C-terminal UBA domain
UBA_N4BP1_C
1
IPR056579
56,579
E3 UFM1-protein ligase 1-like, N-terminal
Ufl1_N
Domain
3,091
false
false
This entry represents the N-terminal region of E3 UFM1-protein ligase 1 (Ufl1) and similar sequences mainly found in animals and plants. The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is kno...
[]
[]
[]
0
[ "PFAM" ]
[ "PF09743" ]
[ "E3_UFM1_ligase" ]
[ 3091 ]
1
[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887", "R-BTA-983168", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-DRE-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168" ]
[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", ...
19
[ "8b9x", "8c0d", "8ohd", "8oj0", "8oj5", "8oj8", "8qfc", "8qfd", "9gy4" ]
9
[ "PUB00054168", "PUB00086011", "PUB00088961", "PUB00095670", "PUB00095671", "PUB00159944" ]
[ "20018847", "20228063", "25219498", "32160526", "20164180", "38383789" ]
[ "A novel type of E3 ligase for the Ufm1 conjugation system.", "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.", "Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development."...
[ 2010, 2010, 2014, 2020, 2010, 2024 ]
6
[]
[]
0
0
null
[ "Candidatus Heimdallarchaeum aukensis", "Eukaryota", "marine sediment metagenome" ]
[ 1, 3085, 5 ]
3
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 1, 2, 2, 1, 1, 2, 7 ]
9
true
Domain
E3 UFM1-protein ligase 1-like, N-terminal
E3 UFM1-protein ligase 1-like, N-terminal
Ufl1_N
9
IPR056580
56,580
E3 UFM1-protein ligase 1-like domain
Ufl1_dom
Domain
2,658
false
false
This domain is found in human E3 UFM1-protein ligase 1 (Ufl1) and similar eukaryotic sequences. This domain, which is predicted to show an all-α configuration, is often found associated to the Ufl1 N-terminal domain . The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose con...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23659" ]
[ "UFL1" ]
[ 2658 ]
1
[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887", "R-BTA-983168", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-DRE-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168" ]
[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", ...
19
[ "8ohd", "8oj0", "8oj5", "8oj8", "8qfc", "8qfd", "9gy4" ]
7
[ "PUB00054168", "PUB00086011", "PUB00088961", "PUB00095670", "PUB00095671", "PUB00159944" ]
[ "20018847", "20228063", "25219498", "32160526", "20164180", "38383789" ]
[ "A novel type of E3 ligase for the Ufm1 conjugation system.", "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.", "Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development."...
[ 2010, 2010, 2014, 2020, 2010, 2024 ]
6
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2658 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 8, 1, 1, 2, 1, 1, 1, 3, 8 ]
9
true
Domain
E3 UFM1-protein ligase 1-like domain
E3 UFM1-protein ligase 1-like domain
Ufl1_dom
6
IPR056581
56,581
Edg1/GEMIN4, TPR repeats region
TPR_Edg1_GEMIN4
Domain
1,008
false
false
This entry represents a region of tetratricopeptide-like repeats found in a group of animal proteins, including protein Edg-1 from Caenorhabditis elegans and human Gem-associated protein 4 (GEMIN4). Edg-1 plays a role in regulating deps-1 cluster formation in the germline [ ]. GEMIN4 is involved in the assembly of smal...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24293" ]
[ "TPR_Edg1" ]
[ 1008 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-191859", "R-HSA-9754678" ]
[ "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678" ]
2
[]
0
[ "PUB00072203", "PUB00155771" ]
[ "18984161", "32843637" ]
[ "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.", "DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans." ]
[ 2008, 2020 ]
2
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 1008 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 1, 5, 3, 4 ]
5
true
Domain
Edg1/GEMIN4, TPR repeats region
Edg1/GEMIN4, TPR repeats region
TPR_Edg1_GEMIN4
6
IPR056582
56,582
EDRF1, N-terminal
EDRF1_N
Domain
2,985
false
false
This entry represents the N-terminal domain of Erythroid differentiation-related factor 1 (EDRF1). EDRF1 is a transcription factor involved in erythroid differentiation and in transcriptional activation of the globin gene [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF23788" ]
[ "EDRF1_N" ]
[ 2985 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155617" ]
[ "12609092" ]
[ "A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells." ]
[ 2002 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2985 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 5, 2, 1, 3, 4, 4, 5, 8 ]
8
true
Domain
EDRF1, N-terminal
EDRF1, N-terminal
EDRF1_N
7
IPR056584
56,584
EF-hand
EF-hand_15
Domain
615
false
false
This entry represents a domain found in a group of fungal proteins that are likely possessing phosphoinositide phospholipase C activity. This domain shares significant similarity to EF-hand domains ( , ) and is predicted to adopt a similar structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF23617" ]
[ "EF-hand_15" ]
[ 615 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 615 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
EF-hand
EF-hand
EF-hand_15
7
IPR056585
56,585
Leprecan-like alpha-helical domain
Leprecan_dom
Domain
5,687
false
false
This entry represents the N-terminal α-helical domain of members of the leprecan family. Members of this family include Prolyl 3-hydroxylase 1/2/3 which often have an associated C-terminal enzymatic domain [ , , ]. This domain is also found in the Cartilage-associated protein CRTAP and in the Endoplasmic reticulum prot...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23557" ]
[ "TPR_leprecan" ]
[ 5687 ]
1
[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "1.14.11.7", "PWY-7894", "R-GGA-1650814", "R-HSA-1650814", "R-MMU-1650814", "R-RNO-1650814" ]
[ "EC:1.14.11.7", "METACYC:PWY-7894", "REACTOME:R-GGA-1650814", "REACTOME:R-HSA-1650814", "REACTOME:R-MMU-1650814", "REACTOME:R-RNO-1650814" ]
6
[ "8k0e", "8k0f", "8k0i", "8k0m", "8k17", "8kc9" ]
6
[ "PUB00078167", "PUB00089828", "PUB00090212", "PUB00159011" ]
[ "17055431", "18487197", "10951563", "27119146" ]
[ "CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.", "Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV.", "Gros1, a potential growth suppressor on chromosome 1: its identity to basemen...
[ 2006, 2008, 2000, 2016 ]
4
[]
[]
0
0
null
[ "Metazoa" ]
[ 5687 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 17, 24, 11, 23 ]
5
true
Domain
Leprecan-like alpha-helical domain
Leprecan-like alpha-helical domain
Leprecan_dom
1
IPR056586
56,586
PLCG1, EF-hand
EF-hand_PLCG1
Domain
2,789
false
false
This entry represents an EF-hand like domain found in animal 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma proteins (PLCG). PLCG1 plays a role in actin reorganisation and cell migration [ ]. PLGC1 has a critical role in maintaining immune homeostasis [ ]. PLCG2 is a crucial enzyme in transmembrane sig...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23329" ]
[ "EF_HAND_1_PLCG" ]
[ 2789 ]
1
[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...
[ "3.1.4.11", "PWY-6351", "PWY-6367", "PWY-7039", "PWY-8052", "R-CEL-1855204", "R-HSA-114604", "R-HSA-1169408", "R-HSA-1236382", "R-HSA-1251932", "R-HSA-1489509", "R-HSA-166016", "R-HSA-167021", "R-HSA-1855204", "R-HSA-186763", "R-HSA-201556", "R-HSA-202433", "R-HSA-2029485", "R-HS...
[ "EC:3.1.4.11", "METACYC:PWY-6351", "METACYC:PWY-6367", "METACYC:PWY-7039", "METACYC:PWY-8052", "REACTOME:R-CEL-1855204", "REACTOME:R-HSA-114604", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-1236382", "REACTOME:R-HSA-1251932", "REACTOME:R-HSA-1489509", "REACTOME:R-HSA-166016", "REACTOME:R-HSA-1...
96
[ "6pbc", "7t8t", "7z3j", "8jqg", "8jqh", "8jqi", "8qju", "8t7c", "9qb7" ]
9
[ "PUB00068259", "PUB00068851", "PUB00082318", "PUB00155618", "PUB00159010", "PUB00160055", "PUB00160056", "PUB00160057" ]
[ "17229814", "23000145", "15194811", "31889510", "37422272", "31918402", "33929486", "37371495" ]
[ "Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.", "A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.", "Inositol 1,4,5-trisphosphate signaling regulates rhythmic contract...
[ 2007, 2012, 2004, 2019, 2023, 2020, 2021, 2023 ]
8
[]
[]
0
0
null
[ "Eumetazoa" ]
[ 2789 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 6, 2, 9, 6, 11 ]
6
true
Domain
PLCG1, EF-hand
PLCG1, EF-hand
EF-hand_PLCG1
1
IPR056587
56,587
EFCAB10, C-terminal EF-hand
EF_EFCAB10_C
Domain
1,138
false
false
This is the second and C-terminal EF hand domain of EF-hand calcium-binding domain-containing protein 10 (EFCAB10) and similar proteins. The function of this protein is not known.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24548" ]
[ "EF_EFCAB10_C" ]
[ 1138 ]
1
[]
[]
[]
0
[ "9fqr" ]
1
[ "PUB00023911", "PUB00023912", "PUB00023940", "PUB00036208", "PUB00036280" ]
[ "1519061", "8259515", "7552748", "9799490", "9195880" ]
[ "Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.", "Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.", "Solution structure of calcium-free calmodulin.", "Simultaneous binding of drugs with different chemical structures to ...
[ 1992, 1993, 1995, 1998, 1997 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1138 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 6, 1, 2 ]
4
true
Domain
EFCAB10, C-terminal EF-hand
EFCAB10, C-terminal EF-hand
EF_EFCAB10_C
7
IPR056589
56,589
Egal-1, winged helix domain
WH_Egal-1
Domain
870
false
false
This entry represents a winged-helix domain found in three copies in the C. elegans protein Egalitarian (Egal-1). This protein functions as part of a complex with BicaudalD (BicD) and dynein light chain (Dlc-1) to recruit the dynein motor complex to specific cargoes and regulate dynein activity. It interacts with both ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23713" ]
[ "WHD_Egal" ]
[ 870 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155916", "PUB00160063", "PUB00160064" ]
[ "20005871", "27017624", "19515976" ]
[ "UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.", "Multiple Roles for Egalitarian in Polarization of the Drosophila Egg Chamber.", "Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor." ]
[ 2010, 2016, 2009 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 870 ]
1
[ "Caenorhabditis elegans", "Drosophila melanogaster" ]
[ 1, 3 ]
2
true
Domain
Egal-1, winged helix domain
Egal-1, winged helix domain
WH_Egal-1
8
IPR056590
56,590
Mua-3/Mup-4, EGF-like domain
Mua-3/Mup-4_EGF
Domain
304
false
false
This entry represents an EGF-like domain found in a variety of nematode cell surface proteins, including Transmembrane cell adhesion receptor mua-3 and Transmembrane matrix receptor MUP-4 from Caenorhabditis elegans. Mua-3 is involved in cell adhesion and required for organ positioning and attachment [ , , ]. Mup-4 is ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23427" ]
[ "EGF_4" ]
[ 304 ]
1
[]
[]
[]
0
[]
0
[ "PUB00086565", "PUB00159013", "PUB00159014", "PUB00159015" ]
[ "25917920", "11470827", "11470828", "9136009" ]
[ "DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.", "MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans.", "mua-3, a gene required for mechanical tissue integrity in Caenorhabdit...
[ 2015, 2001, 2001, 1997 ]
4
[]
[]
0
0
null
[ "Nematoda" ]
[ 304 ]
1
[ "Caenorhabditis elegans" ]
[ 2 ]
1
true
Domain
Mua-3/Mup-4, EGF-like domain
Mua-3/Mup-4, EGF-like domain
Mua-3/Mup-4_EGF
8
IPR056591
56,591
ELP3-like, N-terminal domain
ELP3-like_N
Domain
5,572
false
false
This domain is found N-terminal in Elongator complex protein 3 (ELP3) and related proteins. ELP3 is required for multiple modifications of tRNA. In the elongation complex, it acts as a tRNA uridine(34) acetyltransferase [ ]. It may also act as a lysine acetyltransferase by mediating acetylation of target proteins [ ]. ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23613" ]
[ "ELP3_N" ]
[ 5572 ]
1
[ "EC", "METACYC", "METACYC", "REACTOME" ]
[ "2.3.1.311", "PWY-6829", "PWY-7888", "R-HSA-3214847" ]
[ "EC:2.3.1.311", "METACYC:PWY-6829", "METACYC:PWY-7888", "REACTOME:R-HSA-3214847" ]
4
[ "6ia8", "6iaz", "6qk7", "8asv", "8asw", "8avg", "8ptx", "8pty", "8ptz", "8pu0" ]
10
[ "PUB00100230", "PUB00155622" ]
[ "31309145", "29415125" ]
[ "Molecular basis of tRNA recognition by the Elongator complex.", "Elongator subunit 3 (ELP3) modifies ALS through tRNA modification." ]
[ 2019, 2018 ]
2
[]
[]
0
0
null
[ "Archaea", "Candidatus Nomurabacteria bacterium RIFCSPHIGHO2_01_FULL_39_10", "Eukaryota", "ecological metagenomes" ]
[ 741, 1, 4809, 21 ]
4
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 3, 1, 3, 1, 5, 2, 1, 2, 4, 1, 1, 8 ]
12
true
Domain
ELP3-like, N-terminal domain
ELP3-like, N-terminal domain
ELP3-like_N
4
IPR056592
56,592
F-box protein At3g26010-like, beta-propeller domain
Beta-prop_At3g26010-like
Domain
7,254
false
false
This entry represents the C-terminal β-propeller domain of F-box protein At3g26010 from Arabidopsis thaliana and similar plant proteins. It has been shown that this domain has a strong specificity for ASK13 [ ]. Members of this family contain an F-box domain ( ).
[]
[]
[]
0
[ "PFAM" ]
[ "PF24750" ]
[ "b-prop_At3g26010-like" ]
[ 7254 ]
1
[]
[]
[]
0
[]
0
[ "PUB00096545" ]
[ "23166809" ]
[ "A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins." ]
[ 2012 ]
1
[]
[]
0
0
null
[ "Embryophyta" ]
[ 7254 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 66, 54, 38 ]
3
true
Domain
F-box protein At3g26010-like, beta-propeller domain
F-box protein At3g26010-like, beta-propeller domain
Beta-prop_At3g26010-like
7
IPR056593
56,593
LRRK2, ANK repeat domain
ANK_LRRK2
Domain
1,278
false
false
This entry represents the ankyrin repeat (ANK) found towards the N-terminal end of the Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) from eukaryotes, between the ARM repeat domain ( ) and the LRR domain ( ). The ANK domain plays a key role in this process, as conserved leucine residues within the ANK do...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23745" ]
[ "ANK_LRRK2" ]
[ 1278 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8857538", "R-MMU-8857538" ]
[ "REACTOME:R-HSA-8857538", "REACTOME:R-MMU-8857538" ]
2
[ "6xr4", "7lht", "7lhw", "7li3", "7li4", "8fo2", "8fo8", "8fo9", "8tyq", "8tzb", "8tze", "8tzf", "8tzh", "8u7l", "8u8a", "8u8b", "8vh4", "8vh5", "9cho", "9ci3" ]
20
[ "PUB00155495", "PUB00155496", "PUB00155497", "PUB00155498", "PUB00155499", "PUB00155500" ]
[ "20949042", "29125462", "22012985", "29212815", "34107286", "32783917" ]
[ "Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.", "Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.", "Leucine-rich repeat kinase 2 regulates autophagy through a calcium-d...
[ 2010, 2017, 2012, 2018, 2021, 2020 ]
6
[]
[]
0
0
null
[ "Eukaryota", "Megamimivirinae", "Shimazuella alba" ]
[ 1275, 2, 1 ]
3
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 8, 7, 1, 2 ]
4
true
Domain
LRRK2, ANK repeat domain
LRRK2, ANK repeat domain
ANK_LRRK2
7
IPR056594
56,594
F-box protein AT5G49610-like, beta-propeller domain
AT5G49610-like_b-prop
Domain
6,592
false
false
This entry includes a group of plant proteins containing an F-box domain at the N-terminal, followed by a β-propeller-like domain. The F-box motif is a key component of the SCF (SKP1-cullin-F-box) complex, which functions as an E3 ligase [ ]. Members of this family are likely to play a role in the ubiquitination pathwa...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23635" ]
[ "Beta-prop_AT5G49610-like" ]
[ 6592 ]
1
[]
[]
[]
0
[]
0
[ "PUB00096545" ]
[ "23166809" ]
[ "A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins." ]
[ 2012 ]
1
[]
[]
0
0
null
[ "Mesangiospermae" ]
[ 6592 ]
1
[ "Oryza sativa subsp. japonica", "Zea mays" ]
[ 110, 46 ]
2
true
Domain
F-box protein AT5G49610-like, beta-propeller domain
F-box protein AT5G49610-like, beta-propeller domain
AT5G49610-like_b-prop
4
IPR056595
56,595
FACT complex subunit SPT16, PH-like domain
Fact-SPT16_PH
Domain
5,071
false
false
This domain is found in FACT complex subunit SPT16 and related eukaryotic proteins. It shows similarity to known PH domains. SPT16 is a component of the FACT (facilitator of chromatin transcription) complex, a general chromatin factor that acts to reorganise nucleosomes [ , ]. In budding yeasts, the N-terminal domain (...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24824" ]
[ "PH_SPT16" ]
[ 5071 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-CEL-112382", "R-CEL-674695", "R-CEL-6796648", "R-CEL-6804756", "R-CEL-75955", "R-DDI-674695", "R-DDI-6796648", "R-DDI-6804756", "R-DME-112382", "R-DME-674695", "R-DME-6796648", "R-DME-6804756", "R-DME-75955", "R-HSA-112382", "R-HSA-167152", "R-HSA-167200", "R-HSA-167238", "R-HSA...
[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6796648", "REACTOME:R-CEL-6804756", "REACTOME:R-CEL-75955", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6796648", "REACTOME:R-DDI-6804756", "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-6796648", "REACTOME:R-DME...
36
[ "4ioy", "4kha", "4kho", "4z2m", "4z2n", "5umu", "6upk", "6upl", "7nky", "7xsx", "7xt7", "7xtd", "7xti", "8xgc", "8yjf", "8yjm", "9eh2", "9gw2", "9rzc", "9s0u", "9s3g" ]
21
[ "PUB00070237", "PUB00070238", "PUB00088207" ]
[ "12815073", "10413469", "9489704" ]
[ "Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.", "Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha.", "FACT, a factor that facilit...
[ 2003, 1999, 1998 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5071 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 13, 1, 3, 1, 1, 2, 1, 6, 3, 1, 1, 3 ]
12
true
Domain
FACT complex subunit SPT16, PH-like domain
FACT complex subunit SPT16, PH-like domain
Fact-SPT16_PH
2
IPR056596
56,596
FAD synthase, middle domain
FLAD1_M
Domain
6,734
false
false
This domain is found centrally located in FAD synthase (FLAD1) and similar sequences mainly found in animals. FLAD1 catalyses the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme [ , ]. In FLAD1, this domain is found C-terminal to and N-terminal to . This domain, which is pr...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24102" ]
[ "FLAD1_M" ]
[ 6734 ]
1
[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "2.7.7.2", "3.6.1.18", "3.6.1.22", "PWY-5381", "PWY-6167", "PWY-6168", "PWY-7761", "R-CEL-196843", "R-DRE-196843", "R-HSA-196843", "R-MMU-196843" ]
[ "EC:2.7.7.2", "EC:3.6.1.18", "EC:3.6.1.22", "METACYC:PWY-5381", "METACYC:PWY-6167", "METACYC:PWY-6168", "METACYC:PWY-7761", "REACTOME:R-CEL-196843", "REACTOME:R-DRE-196843", "REACTOME:R-HSA-196843", "REACTOME:R-MMU-196843" ]
11
[ "8ron" ]
1
[ "PUB00043603", "PUB00159016" ]
[ "16643857", "27259049" ]
[ "Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase.", "Riboflavin-Responsive and -Non-responsive Mutations in FAD Synthase Cause Multiple Acyl-CoA Dehydrogenase and Combined Respiratory-Chain Deficiency." ]
[ 2006, 2016 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]
[ 2934, 3203, 544, 53 ]
4
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]
[ 3, 7, 4, 1, 1, 4, 1 ]
7
true
Domain
FAD synthase, middle domain
FAD synthase, middle domain
FLAD1_M
1
IPR056597
56,597
LRRK2, ARM repeat domain
ARM_LRRK2
Domain
2,379
false
false
This entry represents the armadillo repeat (ARM) found at the N-terminal end of Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) from eukaryotes. The domain adopts an ARM-like fold, consisting of a right-handed superhelix formed by two curved layers of repeated helical structural units [ ]. A patch of nega...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23744" ]
[ "ARM_LRRK2" ]
[ 2379 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8857538", "R-MMU-8857538" ]
[ "REACTOME:R-HSA-8857538", "REACTOME:R-MMU-8857538" ]
2
[ "6xr4", "7lht", "7lhw", "7li3", "7li4", "8fo2", "8fo8", "8fo9", "8tyq", "8tzb", "8tze", "8tzf", "8tzh", "8u7l", "8u8a", "8u8b", "8vh4", "8vh5", "9cho", "9ci3" ]
20
[ "PUB00015442", "PUB00094041", "PUB00155495", "PUB00155496", "PUB00155497", "PUB00155498", "PUB00155499", "PUB00155500", "PUB00155504" ]
[ "10361086", "11130075", "20949042", "29125462", "22012985", "29212815", "34107286", "32783917", "31552791" ]
[ "Topological characteristics of helical repeat proteins.", "Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism.", "Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.", "Systematic proteomic analysis of LR...
[ 1999, 2000, 2010, 2017, 2012, 2018, 2021, 2020, 2021 ]
9
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2379 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]
[ 8, 8, 1, 2, 3 ]
5
true
Domain
LRRK2, ARM repeat domain
LRRK2, ARM repeat domain
ARM_LRRK2
3
IPR056598
56,598
FK506-binding protein 15-like domain
FKBP-15_dom
Domain
1,676
false
false
This domain is found in human FK506-binding protein 15 (FKBP15) and similar animal proteins. It is also found in the amoebozoan homologue from Dictyostelium discoideum FK506-binding protein 5 (FKBP5). FKBP15 is involved in the transport of early endosomes and probably in the cytoskeletal organisation of neuronal growth...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23649" ]
[ "FKBP15" ]
[ 1676 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159017" ]
[ "19121306" ]
[ "WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics." ]
[ 2009 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 8, 1668 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 34, 8, 6, 5 ]
4
true
Domain
FK506-binding protein 15-like domain
FK506-binding protein 15-like domain
FKBP-15_dom
2
IPR056600
56,600
T9SS-like, galactose binding domain-like
GBD_T9SS_assoc
Domain
1,099
false
false
This entry represents a galactose binding domain-like that is found up to six times in a variety of bacterial cell surface proteins that usually have a C-terminal type 9 secretion signal domain. The domain contains four conserved cysteines. AlphaFold models suggest that the first and third form one disulphide bond and ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23759" ]
[ "GBD_T9SS_assoc" ]
[ 1099 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 1089, 4, 6 ]
3
[]
[]
0
true
Domain
T9SS-like, galactose binding domain-like
T9SS-like, galactose binding domain-like
GBD_T9SS_assoc
1
IPR056601
56,601
Galaxin-like repeats domain
Galaxin_dom
Domain
1,275
false
false
This entry represents a repetitive region found in galaxins and related proteins. Galaxins are characterised by their role in biomineralization processes [ ]. These proteins are typically involved in the formation of calcium carbonate skeletons in marine organisms, such as corals. They may function by influencing the n...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24748" ]
[ "Galaxin_repeat" ]
[ 1275 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155296" ]
[ "19638240" ]
[ "Differential expression of three galaxin-related genes during settlement and metamorphosis in the scleractinian coral Acropora millepora." ]
[ 2009 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanospirillum", "viral metagenome" ]
[ 8, 1256, 10, 1 ]
4
[ "Caenorhabditis elegans", "Danio rerio" ]
[ 1, 12 ]
2
true
Domain
Galaxin-like repeats domain
Galaxin-like repeats domain
Galaxin_dom
9
IPR056602
56,602
LRRK2, beta-propeller
Beta-prop_LRRK2
Domain
2,143
false
false
This entry represents the β-propeller found at the C-terminal end of the Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) from eukaryotes. The β-propeller domain is suggested to mediate LRRK2 dimerisation and autophosphorylation, and plays an important role in neurotoxicity associated to LRRK2 PD mutations...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23748" ]
[ "Beta-prop_LRRK2" ]
[ 2143 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8857538", "R-MMU-8857538" ]
[ "REACTOME:R-HSA-8857538", "REACTOME:R-MMU-8857538" ]
2
[ "6dlo", "6dlp", "6vno", "6vp6", "6vp7", "6vp8", "6xr4", "7lht", "7lhw", "7li3", "7li4", "8fo2", "8fo7", "8fo8", "8fo9", "8smc", "8txz", "8tyq", "8tzb", "8tzc", "8tze", "8tzf", "8tzg", "8tzh", "8u1b", "8u7h", "8u7l", "8u8a", "8u8b", "8vh4", "8vh5", "9c61"...
35
[ "PUB00130288", "PUB00155495", "PUB00155496", "PUB00155497", "PUB00155498", "PUB00155499", "PUB00155500" ]
[ "20041156", "20949042", "29125462", "22012985", "29212815", "34107286", "32783917" ]
[ "The WD40 domain is required for LRRK2 neurotoxicity.", "Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.", "Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.", "Leucine-ri...
[ 2009, 2010, 2017, 2012, 2018, 2021, 2020 ]
7
[]
[]
0
0
null
[ "Eukaryota", "Sulfurimonas crateris" ]
[ 2142, 1 ]
2
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 10, 3, 7, 2, 5 ]
5
true
Domain
LRRK2, beta-propeller
LRRK2, beta-propeller
Beta-prop_LRRK2
3
IPR056603
56,603
GATOR1 complex protein NPRL3, C-terminal HTH domain
HTH_NPRL3
Domain
3,442
false
false
This domain is found at the C-terminal end of GATOR1 complex protein NPRL3 (NPRL3) and similar proteins, mainly found in animals and fungi. As a component of the GATOR1 complex, NPRL3 functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. This domain shows an helix-turn-helix (HTH) configurat...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24064" ]
[ "HTH_NPRL3" ]
[ 3442 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-9639288", "R-MMU-9639288" ]
[ "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288" ]
2
[ "6ces", "6cet", "7t3a", "7t3b", "7t3c", "8adl", "8ae6", "8fw5", "9h4q", "9h5k", "9v0j" ]
11
[ "PUB00099065", "PUB00151526" ]
[ "29590090", "35338845" ]
[ "Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.", "Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism." ]
[ 2018, 2022 ]
2
[]
[]
0
0
null
[ "Acidianus sulfidivorans JP7", "Bacteria", "Eukaryota" ]
[ 1, 2, 3439 ]
3
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...
[ 2, 15, 2, 6, 4, 1, 3, 1, 1 ]
9
true
Domain
GATOR1 complex protein NPRL3, C-terminal HTH domain
GATOR1 complex protein NPRL3, C-terminal HTH domain
HTH_NPRL3
8
IPR056604
56,604
GBF1-like, tetratricopeptide repeats domain
GBF1-like_TPR
Domain
7,850
false
false
This region of predicted tetratricopeptide repeats (TPR) are found at the C-terminal end of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) and similar eukaryotic proteins. GBF1 is involved in trafficking in the early secretory pathway and required for the assembly of the Golgi apparat...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23325" ]
[ "TPR_28" ]
[ 7850 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-CEL-199992", "R-CEL-6807878", "R-CEL-6811434", "R-HSA-199992", "R-HSA-5620916", "R-HSA-6807878", "R-HSA-6811434", "R-MMU-199992", "R-MMU-5620916", "R-MMU-6807878", "R-MMU-6811434", "R-SCE-199992", "R-SCE-5620916", "R-SCE-6807878", "R-SCE-6811434", "R-SPO-199992", "R-SPO-5620916", ...
[ "REACTOME:R-CEL-199992", "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811434", "REACTOME:R-HSA-199992", "REACTOME:R-HSA-5620916", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-199992", "REACTOME:R-MMU-5620916", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-6811434", "REACTOME:R...
19
[ "7uro", "7urr", "7ut4", "7uth", "8ezj", "8ezq" ]
6
[ "PUB00076748", "PUB00159018", "PUB00159019", "PUB00159020" ]
[ "23386609", "18003980", "19039328", "24213530" ]
[ "The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).", "Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of...
[ 2013, 2008, 2009, 2014 ]
4
[]
[]
0
0
null
[ "Eukaryota" ]
[ 7850 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 28, 1, 6, 4, 17, 4, 1, 16, 3, 2, 1, 145 ]
12
true
Domain
GBF1-like, tetratricopeptide repeats domain
GBF1-like, tetratricopeptide repeats domain
GBF1-like_TPR
1
IPR056605
56,605
LTI65/LTI78, N-terminal domain
LTI65_LTI78_N
Domain
1,136
false
false
This entry represents a disordered region found at the N-terminal of LTI65/LTI78 ( ) from Arabidopsis thaliana and similar sequences from plants [ , , ]. This domain is enriched in V/K/H/E/D amino acids. LTI78 and LTI65 are involved in responses to abiotic stress [ , , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF23403" ]
[ "LTI65_LTI78_N" ]
[ 1136 ]
1
[]
[]
[]
0
[]
0
[ "PUB00016445", "PUB00087049", "PUB00155722" ]
[ "9536054", "21374086", "8437577" ]
[ "Characterization of a gene for spinach CAP160 and expression of two spinach cold-acclimation proteins in tobacco.", "Characterization of abiotic stress-responsive Arabidopsis thaliana RD29A and RD29B genes and evaluation of transgenes.", "Characterization of the expression of a desiccation-responsive rd29 gene...
[ 1998, 2011, 1993 ]
3
[]
[]
0
0
null
[ "Embryophyta" ]
[ 1136 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 20, 4, 8 ]
3
true
Domain
LTI65/LTI78, N-terminal domain
LTI65/LTI78, N-terminal domain
LTI65_LTI78_N
6
IPR056606
56,606
Elapor1/2, C-terminal domain
Elapor1/2_C
Domain
2,798
false
false
This domain is found at the C-terminal of Endosome/lysosome-associated apoptosis and autophagy regulator family members 1/2 (Elapor1/2) and similar sequences predominantly found in vertebrates. It is predicted to adopt a predominantly β structure. Human Elapor1, also known as EIG121 and KIAA1324, is a type I transmembr...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23089" ]
[ "ELAPOR1_C" ]
[ 2798 ]
1
[]
[]
[]
0
[ "9vql", "9vqm" ]
2
[ "PUB00089049", "PUB00094214", "PUB00159021" ]
[ "21072319", "26045166", "21177533" ]
[ "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.", "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.", "A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development." ]
[ 2010, 2015, 2011 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 2798 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 21, 9, 5, 7 ]
4
true
Domain
Elapor1/2, C-terminal domain
Elapor1/2, C-terminal domain
Elapor1/2_C
4
IPR056607
56,607
Elapor1/2, mannose 6-phosphate receptor homology domain
Elapor1/2_MRH
Domain
3,365
false
false
The mannose 6-phosphate receptor homology (MRH) domain is found in Endosome/lysosome-associated apoptosis and autophagy regulator family members 1/2 (Elapor1/2) and similar sequences predominantly found in vertebrates. This domain is predicted to form two orthogonally oriented β-sheets that compose a β-barrel. Human El...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23087" ]
[ "MRH_ELAPOR1_9th" ]
[ 3365 ]
1
[]
[]
[]
0
[ "9vql", "9vqm" ]
2
[ "PUB00089049", "PUB00094214", "PUB00159021" ]
[ "21072319", "26045166", "21177533" ]
[ "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.", "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.", "A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development." ]
[ 2010, 2015, 2011 ]
3
[ "IPR044865" ]
[]
1
0
1
[ "Eumetazoa" ]
[ 3365 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 21, 10, 5, 7 ]
5
true
Domain
Elapor1/2, mannose 6-phosphate receptor homology domain
Elapor1/2, mannose 6-phosphate receptor homology domain
Elapor1/2_MRH
4
IPR056608
56,608
Elapor1/2, galactose binding domain
Elapor1/2_GBD
Domain
3,351
false
false
This domain is found in Endosome/lysosome-associated apoptosis and autophagy regulator family members 1/2 (Elapor1/2) and similar sequences predominantly found in vertebrates. It is predicted to form a β-sandwich with a jelly roll topology typical of a galactose binding domain (GBD). Human Elapor1, also known as EIG121...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23031" ]
[ "GBD_ELAPOR1" ]
[ 3351 ]
1
[]
[]
[]
0
[ "9vql", "9vqm" ]
2
[ "PUB00089049", "PUB00094214", "PUB00159021" ]
[ "21072319", "26045166", "21177533" ]
[ "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.", "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.", "A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development." ]
[ 2010, 2015, 2011 ]
3
[]
[]
0
0
null
[ "Eukaryota", "Flavobacteriaceae" ]
[ 3349, 2 ]
2
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 21, 9, 5, 8 ]
5
true
Domain
Elapor1/2, galactose binding domain
Elapor1/2, galactose binding domain
Elapor1/2_GBD
4
IPR056609
56,609
Elapor1-like, galactose binding domain
Elapor1-like_3rd
Domain
3,543
false
false
This domain is found in Endosome/lysosome-associated apoptosis and autophagy regulator family member 1/2 (Elapor1/2) and similar sequences predominantly found in vertebrates. It is predicted to form a β sandwich with a jelly roll topology typical of a galactose binding domain (GBD). Human Elapor1, also known as EIG121 ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23032" ]
[ "GBD_ELAPOR1-like_3rd" ]
[ 3543 ]
1
[]
[]
[]
0
[ "9vql", "9vqm" ]
2
[ "PUB00089049", "PUB00094214", "PUB00159021" ]
[ "21072319", "26045166", "21177533" ]
[ "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.", "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.", "A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development." ]
[ 2010, 2015, 2011 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3543 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 21, 14, 5, 9 ]
5
true
Domain
Elapor1-like, galactose binding domain
Elapor1-like, galactose binding domain
Elapor1-like_3rd
1
IPR056610
56,610
Elapor1/2, TNF receptor-like
Elapor1/2_TNFR-like
Domain
3,102
false
false
This domain is found in Endosome/lysosome-associated apoptosis and autophagy regulator family members 1/2 (Elapor1/2) and similar sequences predominantly found in vertebrates. This domain, which contain several conserved cysteines, is predicted to adopt a TNF-receptor (TNFR) fold. Human Elapor1, also known as EIG121 an...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23091" ]
[ "TNFR_ELAPOR1_6th" ]
[ 3102 ]
1
[]
[]
[]
0
[ "9vql", "9vqm" ]
2
[ "PUB00089049", "PUB00094214", "PUB00159021" ]
[ "21072319", "26045166", "21177533" ]
[ "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.", "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.", "A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development." ]
[ 2010, 2015, 2011 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3102 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 21, 9, 5, 8 ]
5
true
Domain
Elapor1/2, TNF receptor-like
Elapor1/2, TNF receptor-like
Elapor1/2_TNFR-like
7
IPR056611
56,611
Ecto-NOX disulfide-thiol exchanger 1/2 domain
ENOX1/2_dom
Domain
3,123
false
false
This domain is found in human Ecto-NOX disulfide-thiol exchanger 1/2 (ENOX1/2) and similar sequences mainly found in animals. This domain is predicted to form a long α-helix. ENOX1/2 probably act as terminal oxidases of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface,...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23267" ]
[ "ENOX1" ]
[ 3123 ]
1
[]
[]
[]
0
[]
0
[ "PUB00082751", "PUB00129213", "PUB00129215", "PUB00129220", "PUB00159022" ]
[ "19055324", "11360993", "17027975", "9932650", "12356293" ]
[ "Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase.", "A drug-unresponsive and protease-resistant CNOX protein from human sera.", "A role for copper in biological time-keeping.", "The sulfonylurea-inhibited NADH ox...
[ 2008, 2001, 2006, 1998, 2002 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3123 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 12, 3, 8, 7, 14 ]
5
true
Domain
Ecto-NOX disulfide-thiol exchanger 1/2 domain
Ecto-NOX disulfide-thiol exchanger 1/2 domain
ENOX1/2_dom
2
IPR056612
56,612
Fibulin-2 domain
FIBL-2_dom
Domain
1,097
false
false
This domain is found at the N-terminal region of Fibulin-2 (FIBL-2) and similar proteins from vertebrates. FIBL-2 binds to fibronectin and some other ligands in a calcium dependent manner. It may act as an adapter that mediates the interaction between FBN1 and ELN [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24532" ]
[ "FIBL-2" ]
[ 1097 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-2129379", "R-MMU-2129379" ]
[ "REACTOME:R-HSA-2129379", "REACTOME:R-MMU-2129379" ]
2
[]
0
[ "PUB00155627" ]
[ "17255108" ]
[ "Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin." ]
[ 2007 ]
1
[]
[]
0
0
null
[ "Chordata" ]
[ 1097 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 5, 3, 6 ]
4
true
Domain
Fibulin-2 domain
Fibulin-2 domain
FIBL-2_dom
1
IPR056613
56,613
Protein of unknown function DUF7287
DUF7287
Family
445
false
false
This entry includes uncharacterised archaeal proteins including Uncharacterized protein AF_0763 from Archaeoglobus fulgidus [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF23958" ]
[ "DUF7287" ]
[ 445 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Croceifilum oryzae", "Methanobacteriota" ]
[ 1, 444 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF7287
Protein of unknown function DUF7287
DUF7287
2
IPR056614
56,614
Flagellar attachment zone protein 1, conserved domain
FAZ1_cons
Domain
879
false
false
This entry represents a conserved domain found twice in FAZ1 from Trypanosoma brucei and similar sequences mainly from trypanosomatids [ ]. This domain is found near the central region and at the very C-terminal of FAZ1. At least 50% of the T. cruzi genome is repetitive sequence, consisting mostly of large gene familie...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23398" ]
[ "FAZ1_cons" ]
[ 879 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155625", "PUB00155626" ]
[ "17945531", "1112631" ]
[ "A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei.", "[Experimental trichinosis-I. The course of delayed hypersensitivity in the CBA mouse and Wistar rat (author's transl)]." ]
[ 2008, 1975 ]
2
[]
[]
0
0
null
[ "Metakinetoplastina" ]
[ 879 ]
1
[]
[]
0
true
Domain
Flagellar attachment zone protein 1, conserved domain
Flagellar attachment zone protein 1, conserved domain
FAZ1_cons
2
IPR056615
56,615
FAZ1, C-terminal region
FAZ1_C
Domain
254
false
false
The entry represents a repeats-containing region found towards the C-terminal end of FAZ1 from Trypanosoma brucei brucei and related proteins mainly found in lower eukaryotes. FAZ1 is a component of FAZ filament that is required for correct FAZ assembly and attachment [ ]. These repeats consist of 36x14aa repeats in T....
[]
[]
[]
0
[ "PFAM" ]
[ "PF23404" ]
[ "FAZ1_C" ]
[ 254 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155625" ]
[ "17945531" ]
[ "A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei." ]
[ 2008 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Natrarchaeobius chitinivorans", "Viruses", "marine sediment metagenome" ]
[ 63, 187, 1, 2, 1 ]
5
[]
[]
0
true
Domain
FAZ1, C-terminal region
FAZ1, C-terminal region
FAZ1_C
4
IPR056616
56,616
MIT1, chromo domain
Chromo_MIT1
Domain
1,381
false
false
This domain is found in the Chromatin remodeling factor mit1 (MIT1) from fission yeast and related proteins from fungi. MIT1 is required for proper positioning of the nucleosomes at heterochromatic loci and for transcriptional gene silencing function of the multienzyme effector complex SHREC [ ]. The domain represented...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23615" ]
[ "Chromo_MIT1" ]
[ 1381 ]
1
[]
[]
[]
0
[]
0
[ "PUB00044886" ]
[ "17289569" ]
[ "SHREC, an effector complex for heterochromatic transcriptional silencing." ]
[ 2007 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1381 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1 ]
2
true
Domain
MIT1, chromo domain
MIT1, chromo domain
Chromo_MIT1
3
IPR056617
56,617
Microtubule-associated protein 1B/S, N-terminal domain
MAP1B/S_N
Domain
3,462
false
false
This entry represents the N-terminal domain of Microtubule-associated protein 1B (MAP1B) which, when phosphorylated is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension [ ]. According to the structure predictions and compa...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23415" ]
[ "MAPB1_N" ]
[ 3462 ]
1
[ "REACTOME" ]
[ "R-HSA-9833110" ]
[ "REACTOME:R-HSA-9833110" ]
1
[ "9ijj" ]
1
[ "PUB00059964", "PUB00059965", "PUB00155731" ]
[ "17234756", "15899810", "33268592" ]
[ "Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities.", "Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction.", "Mutat...
[ 2007, 2005, 2020 ]
3
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 3462 ]
1
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 7, 4, 20, 14, 10 ]
5
true
Domain
Microtubule-associated protein 1B/S, N-terminal domain
Microtubule-associated protein 1B/S, N-terminal domain
MAP1B/S_N
9
IPR056618
56,618
Membrane-bound transcription factor PTM, chromo domain-like
Chromo_PTM
Domain
1,475
false
false
This is a putative chromo domain-like domain found in the membrane-bound transcription factor PTM (also known as DDP1) and similar plant sequences. PTM is required for the plastid-to-nucleus retrograde signalling, which plays an important role in the coordinated expression of both nuclear- and chloroplast-localised gen...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24294" ]
[ "Chromo_PTM" ]
[ 1475 ]
1
[]
[]
[]
0
[]
0
[ "PUB00102726" ]
[ "21934661" ]
[ "A chloroplast envelope-bound PHD transcription factor mediates chloroplast signals to the nucleus." ]
[ 2011 ]
1
[]
[]
0
0
null
[ "Spermatophyta" ]
[ 1475 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 18, 8, 25 ]
3
true
Domain
Membrane-bound transcription factor PTM, chromo domain-like
Membrane-bound transcription factor PTM, chromo domain-like
Chromo_PTM
5
IPR056619
56,619
Mucin-4-like, C8-3 domain
C8-3_MUC4
Domain
3,210
false
false
This domain is found in human Mucin-4 (MUC4) and related proteins, including SUSD2 and MESH. It is usually found next to VWD domain ( ). Despite lack of sequence similarity, it is predicted to adopt similar structure to the C8-3 domain of MUC2, consisting of three α-helical bundle. This domain contains two highly conse...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23263" ]
[ "C8-3_MUC4" ]
[ 3210 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5083625", "R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-MMU-913709", "R-MMU-977068", "R-RNO-913709", "R-RNO-977068" ]
[ "REACTOME:R-HSA-5083625", "REACTOME:R-HSA-5083632", "REACTOME:R-HSA-5083636", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-977068", "REACTOME:R-MMU-913709", "REACTOME:R-MMU-977068", "REACTOME:R-RNO-913709", "REACTOME:R-RNO-977068" ]
10
[]
0
[ "PUB00155562" ]
[ "10880978" ]
[ "Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins." ]
[ 2000 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 3210 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 6, 2, 25, 4, 8 ]
6
true
Domain
Mucin-4-like, C8-3 domain
Mucin-4-like, C8-3 domain
C8-3_MUC4
9
IPR056620
56,620
HTH domain upstream PIN-TPR-GreABC
HTH_next_PIN-TPR-GreABC
Domain
94
false
false
This is a HTH domain found next to the double PIN in the TPR-GreAB-C-PIN type conflict system ( ) [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24407" ]
[ "HTH_upst_double_PIN" ]
[ 94 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155486" ]
[ "37889040" ]
[ "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]
[ 2023 ]
1
[]
[]
0
0
null
[ "Bacteria", "marine sediment metagenome" ]
[ 93, 1 ]
2
[]
[]
0
true
Domain
HTH domain upstream PIN-TPR-GreABC
HTH domain upstream PIN-TPR-GreABC
HTH_next_PIN-TPR-GreABC
2
IPR056621
56,621
IL27B, N-terminal Fn3 domain
FN3_IL27B_N
Domain
1,129
false
false
This entry represents the Fibronectin type III (FN3) domain found at the N-terminal end of Interleukin-27 subunit beta (IL27B), from animals. This domain is found in association with a C-terminal FN3 ( ). Also known as EBI3, IL27B binds p28 to form the heterodimeric cytokine IL-27, which plays an important role in inna...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24031" ]
[ "FN3_IL27B_N" ]
[ 1129 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-8984722", "R-HSA-9020956", "R-MMU-8984722", "R-MMU-9020956" ]
[ "REACTOME:R-HSA-8984722", "REACTOME:R-HSA-9020956", "REACTOME:R-MMU-8984722", "REACTOME:R-MMU-9020956" ]
4
[ "7u7n", "7z0l", "7zg0", "7zxk", "8d85", "8xwy" ]
6
[ "PUB00060212", "PUB00155632" ]
[ "12121660", "35920255" ]
[ "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.", "Structural insights into the assembly and activation of the IL-27 signaling complex." ]
[ 2002, 2022 ]
2
[ "IPR003961" ]
[]
1
0
1
[ "Vertebrata" ]
[ 1129 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 10, 1, 2, 2 ]
4
true
Domain
IL27B, N-terminal Fn3 domain
IL27B, N-terminal Fn3 domain
FN3_IL27B_N
8
IPR056622
56,622
FBXO47, ARM repeats region
ARM_FBXO47
Domain
987
false
false
This is the C-terminal region of human F-box only protein 47 (FBXO47) and similar metazoan sequences. This region is predicted to consist of armadillo (ARM)-like repeats. The function of FBXO47 is not clear. It may play a role in carcinogenesis [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF24467" ]
[ "ARM_FBXO47" ]
[ 987 ]
1
[]
[]
[]
0
[]
0
[ "PUB00088588" ]
[ "15723337" ]
[ "Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Metazoa" ]
[ 987 ]
1
[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 1, 1, 2 ]
4
true
Domain
FBXO47, ARM repeats region
FBXO47, ARM repeats region
ARM_FBXO47
6
IPR056623
56,623
MLLE-like domain
MLLE_2
Domain
393
false
false
This entry represents a domain related to the MLLE domain found in a set of plant proteins. This domain is likely to function as a peptide binding domain.
[]
[]
[]
0
[ "PFAM" ]
[ "PF23950" ]
[ "MLLE_2" ]
[ 393 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Mesangiospermae" ]
[ 393 ]
1
[ "Oryza sativa subsp. japonica", "Zea mays" ]
[ 18, 98 ]
2
true
Domain
MLLE-like domain
MLLE-like domain
MLLE_2
7
IPR056624
56,624
Mitochondrial protein cyt-4, winged helix domain
WH_CYT4
Domain
1,050
false
false
This entry represents a winged helix domain found in mitochondrial protein CYT4 from Neurospora crassa and related fungal sequences. CYT4 is a nuclear-encoded protein that plays a crucial role in RNA processing and splicing within mitochondria [ , ]. CYT4 is required for mitochondrial RNA 5'- and 3'-end processing and ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23216" ]
[ "WHD_CYT4" ]
[ 1050 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159023", "PUB00160646" ]
[ "2478417", "1311848" ]
[ "Mutations in nuclear gene cyt-4 of Neurospora crassa result in pleiotropic defects in processing and splicing of mitochondrial RNAs.", "A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions." ]
[ 1989, 1992 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1050 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Mitochondrial protein cyt-4, winged helix domain
Mitochondrial protein cyt-4, winged helix domain
WH_CYT4
1
IPR056625
56,625
Mitochondrial protein cyt-4, SH3 domain
SH3_CYT4
Domain
995
false
false
This entry represents a SH3 domain found in mitochondrial protein CYT4 from Neurospora crassa and related fungal sequences. CYT4 is a nuclear-encoded protein that plays a crucial role in RNA processing and splicing within mitochondria [ , ]. CYT4 is required for mitochondrial RNA 5'- and 3'-end processing and splicing ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23214" ]
[ "SH3_CYT4" ]
[ 995 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159023", "PUB00160646" ]
[ "2478417", "1311848" ]
[ "Mutations in nuclear gene cyt-4 of Neurospora crassa result in pleiotropic defects in processing and splicing of mitochondrial RNAs.", "A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions." ]
[ 1989, 1992 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 995 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Mitochondrial protein cyt-4, SH3 domain
Mitochondrial protein cyt-4, SH3 domain
SH3_CYT4
4
IPR056626
56,626
Phage zinc binding domain
Znf_bind_phage
Domain
179
false
false
This entry represents a small zinc binding domain found in a small family of uncharacterised mycobacterium phage proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24331" ]
[ "Phage_zn_bind_7" ]
[ 179 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Caudoviricetes" ]
[ 179 ]
1
[]
[]
0
true
Domain
Phage zinc binding domain
Phage zinc binding domain
Znf_bind_phage
7
IPR056627
56,627
Bacteriophage transmembrane helix
TM_bacteriophage
Family
192
false
false
This entry represents a family of proteins of unknown function found in mycobacteriophage. The family includes short proteins between 44-60 amino acids in length that contain a single predicted transmembrane helix. The presence of these proteins in numerous mycobacteriophage suggests they may play a role in phage biolo...
[]
[]
[]
0
[ "PFAM" ]
[ "PF24191" ]
[ "Mycobacteriophage_TM" ]
[ 192 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Caudoviricetes", "Mycolicibacterium frederiksbergense" ]
[ 191, 1 ]
2
[]
[]
0
true
Family
Bacteriophage transmembrane helix
Bacteriophage transmembrane helix
TM_bacteriophage
7
IPR056628
56,628
Monkey King protein, C-terminal domain
Mkg_C
Domain
71
false
false
This entry represents the C-terminal domain of a family of proteins largely found in insect species. This domain structurally resembles the KA1 domain . This domain is found in the Monkey King proteins [ ]. Monkey King is a Drosophilidae-specific protein that emerged from duplication and divergence of the ancestral TUT...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23712" ]
[ "Mkg_C" ]
[ 71 ]
1
[]
[]
[]
0
[]
0
[ "PUB00155747" ]
[ "28633361" ]
[ "Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa." ]
[ 2017 ]
1
[]
[]
0
0
null
[ "Diptera" ]
[ 71 ]
1
[ "Drosophila melanogaster" ]
[ 2 ]
1
true
Domain
Monkey King protein, C-terminal domain
Monkey King protein, C-terminal domain
Mkg_C
4
IPR056629
56,629
N4BP1, first type I KH-domain
KH_N4BP1_1st
Domain
1,663
false
false
This domain is found in the N4BP1 family which includes NEDD4-binding protein 1, KHNYN, NYNRIN and other related proteins. Members of this family contain two type I K homology (KH) domains. This entry represents the first KH domain. N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate ...
[]
[]
[]
0
[ "PFAM", "CDD" ]
[ "PF23050", "cd09032" ]
[ "KH_N4BP1_1st", "KH-I_N4BP1_like_rpt1" ]
[ 1657, 1396 ]
2
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DRE-9758274", "R-HSA-9758274", "R-MMU-9758274", "R-XTR-9758274" ]
[ "REACTOME:R-DRE-9758274", "REACTOME:R-HSA-9758274", "REACTOME:R-MMU-9758274", "REACTOME:R-XTR-9758274" ]
4
[ "6q3v", "9cs9", "9hts" ]
3
[ "PUB00101187", "PUB00109293", "PUB00109294", "PUB00109295", "PUB00109296", "PUB00109297", "PUB00109298", "PUB00109299", "PUB00109300", "PUB00159024" ]
[ "31133753", "17592138", "24141722", "30213788", "28350078", "20233849", "31284899", "31748389", "19561090", "32971525" ]
[ "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.", "The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.", "p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.", "Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Contro...
[ 2019, 2007, 2014, 2018, 2017, 2010, 2019, 2020, 2009, 2020 ]
10
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 1663 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 6, 5, 6, 5 ]
4
true
Domain
N4BP1, first type I KH-domain
N4BP1, first type I KH-domain
KH_N4BP1_1st
3
IPR056630
56,630
N4BP1, second type I KH-domain
KH_N4BP1_2nd
Domain
1,757
false
false
This domain is found in the N4BP1 family which includes NEDD4-binding protein 1, KHNYN, NYNRIN and other related proteins. Members of this family contain two type I K homology (KH) domains. This entry represents the second KH domain. Besides the typical for the KH domains secondary structures and topology, this domain ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23052" ]
[ "KH_N4BP1_2nd" ]
[ 1757 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DRE-9758274", "R-HSA-9758274", "R-MMU-9758274", "R-XTR-9758274" ]
[ "REACTOME:R-DRE-9758274", "REACTOME:R-HSA-9758274", "REACTOME:R-MMU-9758274", "REACTOME:R-XTR-9758274" ]
4
[ "6q3v", "9cs9", "9hts" ]
3
[ "PUB00101187", "PUB00159024" ]
[ "31133753", "32971525" ]
[ "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.", "Integration of innate immune signalling by caspase-8 cleavage of N4BP1." ]
[ 2019, 2020 ]
2
[]
[]
0
0
null
[ "Chordata" ]
[ 1757 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 6, 6, 7 ]
4
true
Domain
N4BP1, second type I KH-domain
N4BP1, second type I KH-domain
KH_N4BP1_2nd
1
IPR056631
56,631
N4BP1, UBA-like domain
UBA_N4BP1
Domain
874
false
false
This domain is found in the human NEDD4-binding protein 1 (N4BP1) and related proteins. It has a significant sequence and structural similarity to UBA domains. This domain is predicted to adopt a globular structure consisting of a three helical bundle. N4BP1 is a potent suppressor of cytokine production that acts as a ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23053" ]
[ "UBA_N4BP1" ]
[ 874 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-DRE-9758274", "R-HSA-9758274", "R-MMU-9758274", "R-XTR-9758274" ]
[ "REACTOME:R-DRE-9758274", "REACTOME:R-HSA-9758274", "REACTOME:R-MMU-9758274", "REACTOME:R-XTR-9758274" ]
4
[]
0
[ "PUB00101187", "PUB00159024" ]
[ "31133753", "32971525" ]
[ "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.", "Integration of innate immune signalling by caspase-8 cleavage of N4BP1." ]
[ 2019, 2020 ]
2
[]
[]
0
0
null
[ "Vertebrata" ]
[ 874 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 1, 2, 3 ]
4
true
Domain
N4BP1, UBA-like domain
N4BP1, UBA-like domain
UBA_N4BP1
3
IPR056633
56,633
Domain of unknown function DUF7731
DUF7731
Domain
1,098
false
false
This entry represents a domain found in uncharacterised plant proteins. It contains a set of conserved cysteines that are predicted to form disulfide bonds.
[]
[]
[]
0
[ "PFAM" ]
[ "PF24865" ]
[ "DUF7731" ]
[ 1098 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Embryophyta" ]
[ 1098 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 10, 13, 8 ]
3
true
Domain
Domain of unknown function DUF7731
Domain of unknown function DUF7731
DUF7731
4