LiteFold/InterPro · Datasets at Hugging Face

IPR057228

57,228

Domain of unknown function DUF7906

DUF7906

Domain

2,107

false

This domain is found in uncharacterised plant proteins. It is predicted to adopt a globular α/β structure.

[]

0

[ "PFAM" ]

[ "PF25483" ]

[ "DUF7906" ]

[ 2107 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 2106, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 16, 13, 31 ]

3

true

Domain

Domain of unknown function DUF7906

DUF7906

4

IPR057229

57,229

Domain of unknown function DUF7907

DUF7907

Domain

2,181

false

This domain is found in uncharacterised fungal proteins. It is predicted to adopt beta-Trefoil fold. It is probably distantly related to domains members of .

[]

0

[ "PFAM" ]

[ "PF25484" ]

[ "DUF7907" ]

[ 2181 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2181 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF7907

DUF7907

6

IPR057230

57,230

Domain of unknown function DUF7908

DUF7908

Domain

1,458

false

This domain is found in uncharacterised fungal proteins. It is predicted to adopt beta-Trefoil fold.

[]

0

[ "PFAM" ]

[ "PF25485" ]

[ "DUF7908" ]

[ 1458 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacterioplanes sanyensis", "Dikarya" ]

[ 1, 1457 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF7908

DUF7908

7

IPR057231

57,231

Domain of unknown function DUF7909

DUF7909

Domain

243

false

This domain is found in uncharacterised fungal proteins. It is predicted to adopt beta-Trefoil fold.

[]

0

[ "PFAM" ]

[ "PF25486" ]

[ "DUF7909" ]

[ 243 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pezizomycotina" ]

[ 243 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF7909

DUF7909

1

IPR057232

57,232

Domain of unknown function DUF7910

DUF7910

Domain

2,182

false

This domain is found in uncharacterised plant proteins. It is predicted to adopt beta-Trefoil fold. It is closely related to members of Fascin .

[]

0

[ "PFAM" ]

[ "PF25490" ]

[ "DUF7910" ]

[ 2182 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)", "Pandoravirus", "metagenomes" ]

[ 140, 2028, 1, 11, 2 ]

5

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 10 ]

2

true

Domain

Domain of unknown function DUF7910

DUF7910

9

IPR057233

57,233

Repeat of unknown function DUF7911

DUF7911

Repeat

118

false

This domain is found in uncharacterised nematode proteins. It is predicted to fold into a five-bladed β-propeller.

[]

0

[ "PFAM" ]

[ "PF25492" ]

[ "DUF7911" ]

[ 118 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 118 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Repeat

Repeat of unknown function DUF7911

DUF7911

4

IPR057234

57,234

Domain of unknown function DUF7912

DUF7912

Domain

1,065

false

This domain is found in uncharacterised plant proteins. It is predicted to adopt an SH3-like fold.

[]

0

[ "PFAM" ]

[ "PF25498" ]

[ "DUF7912" ]

[ 1065 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1065 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 7, 11 ]

3

true

Domain

Domain of unknown function DUF7912

DUF7912

7

IPR057235

57,235

Domain of unknown function DUF7913

DUF7913

Domain

883

false

This domain is found in uncharacterised plant proteins. It is predicted to fold into an array of four α-helices.

[]

0

[ "PFAM" ]

[ "PF25500" ]

[ "DUF7913" ]

[ 883 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Tracheophyta" ]

[ 883 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 3, 4 ]

3

true

Domain

Domain of unknown function DUF7913

DUF7913

5

IPR057236

57,236

Repeat of unknown function DUF7914

DUF7914

Repeat

45

false

This domain is found in uncharacterised proteins mainly from Trypanosomes. It is predicted to fold into a seven-bladed β-propeller.

[]

0

[ "PFAM" ]

[ "PF25501" ]

[ "DUF7914" ]

[ 45 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Trypanosomatidae" ]

[ 45 ]

1

[]

0

true

Repeat

Repeat of unknown function DUF7914

DUF7914

7

IPR057237

57,237

Domain of unknown function DUF7915

DUF7915

Domain

935

false

This domain is found in uncharacterised plant proteins. It is predicted to fold into an α/β structure consisting of a central mixed β-sheet and α-helices packed on both sides. It is usually found C-terminal to .

[]

0

[ "PFAM" ]

[ "PF25502" ]

[ "DUF7915" ]

[ 935 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Tracheophyta" ]

[ 935 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 4 ]

3

true

Domain

Domain of unknown function DUF7915

DUF7915

7

IPR057238

57,238

Domain of unknown function DUF7916

DUF7916

Domain

1,348

false

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a TIM-barrel structure. It shares detectable similarity with Mycobacterium tuberculosis Indole-3-glycerol phosphate synthase (TrpC).

[]

0

[ "PFAM" ]

[ "PF25509" ]

[ "DUF7916" ]

[ 1348 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Thermofilaceae", "ecological metagenomes" ]

[ 1335, 9, 4 ]

3

[]

0

true

Domain

Domain of unknown function DUF7916

DUF7916

3

IPR057240

57,240

ParB, C-terminal dimerisation domain

ParB_dimer_C

Domain

20,245

false

This entry represents the C-terminal dimerisation domain found in ParB proteins. The dimerisation domain tightly links the two subunits of the ParB dimer [ ]. Structural analysis of the C-terminal domain reveals a dimer with a lysine-rich surface that binds DNA non-specifically and is essential for DNA condensation in ...

[]

0

[ "PFAM" ]

[ "PF23552" ]

[ "ParB_C" ]

[ 20245 ]

1

[]

0

[ "5noc" ]

1

[ "PUB00032130", "PUB00153776", "PUB00160261", "PUB00160262", "PUB00160263" ]

[ "15228524", "15917647", "29244022", "34562373", "38142222" ]

[ "Structural analysis of the chromosome segregation protein Spo0J from Thermus thermophilus.", "Evolution of eukaryotic cysteine sulfinic acid reductase, sulfiredoxin (Srx), from bacterial chromosome partitioning protein ParB.", "The structural basis for dynamic DNA binding and bridging interactions which conden...

[ 2004, 2005, 2017, 2021, 2024 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19818, 36, 391 ]

3

[]

0

true

Domain

ParB, C-terminal dimerisation domain

ParB_dimer_C

5

IPR057241

57,241

ParB-like, catalytic effector domain

Parb-CE

Domain

54

false

This entry represents a ParB-like domain predicted to act as a catalytic effector (CE) in multiple antiviral immunity systems and predicted to target nucleotides along with Calcineurin-CE, HD-CE and PRTase-CE [ ]. ParB plays a vital role in chromosome partitioning and nucleoid occlusion. These proteins are essential fo...

[]

0

[ "PFAM" ]

[ "PF24392" ]

[ "Parb-CE" ]

[ 54 ]

1

[]

0

[]

0

[ "PUB00032130", "PUB00153776", "PUB00155486", "PUB00160262", "PUB00160263" ]

[ "15228524", "15917647", "37889040", "34562373", "38142222" ]

[ "Structural analysis of the chromosome segregation protein Spo0J from Thermus thermophilus.", "Evolution of eukaryotic cysteine sulfinic acid reductase, sulfiredoxin (Srx), from bacterial chromosome partitioning protein ParB.", "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors ...

[ 2004, 2005, 2023, 2021, 2024 ]

5

[]

0

null

[ "Bacteria", "invertebrate metagenome" ]

[ 53, 1 ]

2

[]

0

true

Domain

ParB-like, catalytic effector domain

Parb-CE

1

IPR057242

57,242

PCFS4-like, zinc finger domain

PCFS4-like

Domain

2,386

false

This zinc finger domain is found in the homologues of polyadenylation and cleavage factor homolog 4 (PCFS4) including PCFS1, PCFS5 and other RNA-binding proteins in eukaryotes. This domain contains three highly conserved cysteine residues and histidine. Its structure is predicted to be similar to known Treble clef zinc...

[]

0

[ "PFAM" ]

[ "PF23228" ]

[ "zf_PCFS4" ]

[ 2386 ]

1

[]

0

[]

0

[ "PUB00155937", "PUB00155938" ]

[ "18298670", "21364912" ]

[ "Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time.", "Ratio-based analysis of differential mRNA processing and expression of a polyadenylation factor mutant pcfs4 using arabidopsis tiling microarray." ]

[ 2008, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2386 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 8, 24 ]

3

true

Domain

PCFS4-like, zinc finger domain

PCFS4-like

1

IPR057243

57,243

Integrins beta, I-EGF domain, conserved site

Integrin_I-EGF_CS

Conserved_site

14,095

false

This entry represents a conserved region of the I-EGF domain that includes five of the conserved cysteines. The C terminus of the extracellular region of all the integrin beta chains has four cysteine-rich tandem repeats of forty amino acids, which are variants of the EGF-like domain, termed integrin- or I-EGF domains....

[]

0

[ "PROSITE" ]

[ "PS00243" ]

[ "I_EGF_1" ]

[ 14095 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1566948", "R-BTA-166016", "R-BTA-198933", "R-BTA-202733", "R-BTA-2129379", "R-BTA-216083", "R-BTA-2173789", "R-BTA-3000178", "R-BTA-6798695", "R-CEL-114608", "R-CEL-1236973", "R-CEL-1566977", "R-CEL-198933", "R-CEL-202733", "R-CEL-210991", "R-CEL-2129379", "R-CEL-216083", "R...

[ "REACTOME:R-BTA-1566948", "REACTOME:R-BTA-166016", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-202733", "REACTOME:R-BTA-2129379", "REACTOME:R-BTA-216083", "REACTOME:R-BTA-2173789", "REACTOME:R-BTA-3000178", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1236973", "REACTOME:R-C...

166

[ "1jv2", "1l3y", "1l5g", "1m1x", "1u8c", "2p26", "2p28", "3fcs", "3ije", "3k6s", "3k71", "3k72", "4cak", "4g1e", "4g1m", "4mmx", "4mmy", "4mmz", "4neh", "4nen", "4o02", "4um8", "5e6w", "5e6x", "5es4", "6avq", "6avr", "6avu", "6bxb", "6bxf", "6bxj", "6ckb"...

82

[ "PUB00000811", "PUB00001505", "PUB00002561", "PUB00002637", "PUB00002660", "PUB00009789", "PUB00015915", "PUB00015985", "PUB00026914", "PUB00035000", "PUB00035002" ]

[ "3028640", "2199285", "2365683", "2040616", "1918072", "12297042", "14689578", "2467745", "11896403", "12361595", "12234368" ]

[ "Integrins: a family of cell surface receptors.", "Integrins and other cell adhesion molecules.", "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.", "Complete amino acid sequence of an integrin beta subunit (beta 7) ide...

[ 1987, 1990, 1990, 1991, 1991, 2002, 2004, 1989, 2002, 2002, 2002 ]

11

[]

0

null

[ "Eukaryota", "Nocardia" ]

[ 14093, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 30, 8, 43, 17, 35 ]

6

true

Conserved_site

Integrins beta, I-EGF domain, conserved site

Integrin_I-EGF_CS

9

IPR057244

57,244

GAIN, subdomain B

GAIN_B

Domain

48,138

false

This entry represents the entire subdomain B of GAIN. The ~320-residue GAIN domain is an ancient domain that exists in primitive ancestor organisms, and is conserved in all aGPCRs and all PKD1-related proteins. Functionally, the GAIN domain is both necessary and sufficient for autoproteolysis, suggesting an autoproteol...

[]

0

[ "PROFILE" ]

[ "PS50221" ]

[ "GAIN_B" ]

[ 48138 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-350368", "R-DME-350376", "R-DME-350379", "R-DME-350411", "R-DME-350480", "R-DME-373080", "R-DME-450728", "R-DME-6798695", "R-DRE-9619665", "R-HSA-373080", "R-HSA-5620916", "R-HSA-5683826", "R-HSA-6798695", "R-HSA-9619665", "R-MMU-373080", "R-MMU-5620916", "R-MMU-5683826", "R...

[ "REACTOME:R-DME-350368", "REACTOME:R-DME-350376", "REACTOME:R-DME-350379", "REACTOME:R-DME-350411", "REACTOME:R-DME-350480", "REACTOME:R-DME-373080", "REACTOME:R-DME-450728", "REACTOME:R-DME-6798695", "REACTOME:R-DRE-9619665", "REACTOME:R-HSA-373080", "REACTOME:R-HSA-5620916", "REACTOME:R-HSA-...

21

[ "4dlo", "4dlq", "5kvm", "6v55", "6vhh", "7d76", "7d77", "7qu8", "7wu3", "7wu4", "7wu5", "7wui", "7wxu", "7wxw", "7wy0", "7wy5", "7wy8", "7wyb", "7wz7", "7x10", "7x2v", "7xke", "7yp7", "8hc0", "8ikj", "8jmt", "8oek", "8vti", "8vy2", "8x9s", "8x9t", "8x9u"...

36

[ "PUB00005835", "PUB00008017", "PUB00018218", "PUB00058430", "PUB00091220", "PUB00100163", "PUB00101119", "PUB00160216", "PUB00160217" ]

[ "9830014", "10469603", "10026162", "22333914", "27657451", "23850273", "22938866", "36716818", "27832484" ]

[ "alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis.", "A latrophilin/CL-1-like GPS domain in polycystin-1.", "A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the...

[ 1998, 1999, 1999, 2012, 2016, 2013, 2012, 2023, 2016 ]

9

[]

[ "IPR053986" ]

0

1

0

[ "Eukaryota", "Streptococcus zhangguiae", "organismal metagenomes" ]

[ 48130, 1, 7 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 483, 15, 157, 112, 175 ]

6

true

Domain

GAIN, subdomain B

GAIN_B

2

IPR057246

57,246

Zinc carboxypeptidases, zinc-binding region 1

CARBOXYPEPT_ZN_1

Binding_site

25,873

false

There are conserved sites matching these three zinc-ligands - this entry and . If a protein includes both signatures, the probability of it being a eukaryotic zinc carboxypeptidase is very high. There are a number of different types of zinc-dependent carboxypeptidases (EC 3.4.17.-) [ , ]. All these enzymes seem to be s...

[]

0

[ "PROSITE" ]

[ "PS00132" ]

[ "CARBOXYPEPT_ZN_1" ]

[ 25873 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.17", "R-BTA-2022377", "R-DME-2022377", "R-DME-432722", "R-HSA-163125", "R-HSA-2022377", "R-HSA-264876", "R-HSA-432722", "R-HSA-9696264", "R-HSA-9696273", "R-HSA-977606", "R-HSA-9925561", "R-MMU-163125", "R-MMU-2022377", "R-MMU-432722", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-...

[ "EC:3.4.17", "REACTOME:R-BTA-2022377", "REACTOME:R-DME-2022377", "REACTOME:R-DME-432722", "REACTOME:R-HSA-163125", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696273", "REACTOME:R-HSA-977606", "REACTOME:R-HSA-9925561", ...

23

[ "1arl", "1arm", "1aye", "1bav", "1cbx", "1cpb", "1cps", "1cpx", "1dtd", "1ee3", "1ell", "1elm", "1f57", "1h8l", "1hdq", "1hdu", "1hee", "1iy7", "1kwm", "1m4l", "1nsa", "1obr", "1pca", "1pyt", "1qmu", "1uwy", "1yme", "1z5r", "1zg7", "1zg8", "1zg9", "1zlh"...

123

[ "PUB00001425", "PUB00002340", "PUB00002502", "PUB00002524", "PUB00004226" ]

[ "1521526", "2118139", "2753907", "2584208", "7477299" ]

[ "Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris.", "The amino acid sequence of zinc-carboxypeptidase from Streptomyces griseus.", "Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.", "Isolation a...

[ 1992, 1990, 1989, 1989, 1995 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 10, 4009, 21802, 52 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 4, 31, 28, 39, 20, 1, 2, 44, 1, 1, 12 ]

12

true

Binding_site

Zinc carboxypeptidases, zinc-binding region 1

CARBOXYPEPT_ZN_1

7

IPR057247

57,247

Zinc carboxypeptidases, zinc-binding region 2

CARBOXYPEPT_ZN_2

Binding_site

18,539

false

There are two conserved sites matching these three zinc-ligands - this entry and . If a protein includes both, the probability of it being a eukaryotic zinc carboxypeptidase is very high. There are a number of different types of zinc-dependent carboxypeptidases (EC 3.4.17.-) [ , ]. All these enzymes seem to be structur...

[]

0

[ "PROSITE" ]

[ "PS00133" ]

[ "CARBOXYPEPT_ZN_2" ]

[ 18539 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.17", "R-BTA-2022377", "R-CEL-2022377", "R-DME-432722", "R-HSA-163125", "R-HSA-2022377", "R-HSA-264876", "R-HSA-432722", "R-HSA-9696264", "R-HSA-9696273", "R-HSA-977606", "R-HSA-9925561", "R-MMU-163125", "R-MMU-2022377", "R-MMU-432722", "R-MMU-9696264", "R-MMU-9696273", "R-MMU-...

[ "EC:3.4.17", "REACTOME:R-BTA-2022377", "REACTOME:R-CEL-2022377", "REACTOME:R-DME-432722", "REACTOME:R-HSA-163125", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696273", "REACTOME:R-HSA-977606", "REACTOME:R-HSA-9925561", ...

23

[ "1arl", "1arm", "1aye", "1bav", "1cbx", "1cpb", "1cps", "1cpx", "1dtd", "1ee3", "1ell", "1elm", "1f57", "1h8l", "1hdq", "1hdu", "1hee", "1iy7", "1kwm", "1m4l", "1nsa", "1obr", "1pca", "1pyt", "1qmu", "1uwy", "1yme", "1z5r", "1zg7", "1zg8", "1zg9", "1zlh"...

115

[ "PUB00001425", "PUB00002340", "PUB00002502", "PUB00002524", "PUB00004226" ]

[ "1521526", "2118139", "2753907", "2584208", "7477299" ]

[ "Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris.", "The amino acid sequence of zinc-carboxypeptidase from Streptomyces griseus.", "Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.", "Isolation a...

[ 1992, 1990, 1989, 1989, 1995 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Elemovirus", "Eukaryota", "metagenomes" ]

[ 16, 1674, 6, 16821, 22 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 9, 7, 28, 20, 36, 19, 2, 48, 1, 15 ]

10

true

Binding_site

Zinc carboxypeptidases, zinc-binding region 2

CARBOXYPEPT_ZN_2

2

IPR057248

57,248

Alsin-like, PH-like domain

Alsin-like_PH

Domain

2,653

false

This entry represents the Pleckstrin Homology (PH) domain found in Alsin (ALS2) proteins and ALS2-like proteins. The PH domain is likely involved in membrane targeting through phospholipid binding [ , , ]. Alsin functions as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, particularly Rac1, in additi...

[]

0

[ "PFAM", "CDD" ]

[ "PF25383", "cd13269" ]

[ "PH_alsin", "PH_alsin" ]

[ 2644, 1651 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8876198", "R-DME-8876198", "R-DME-9013149", "R-HSA-8876198", "R-HSA-9013149", "R-MMU-8876198", "R-MMU-9013149", "R-RNO-8876198", "R-RNO-9013149" ]

[ "REACTOME:R-BTA-8876198", "REACTOME:R-DME-8876198", "REACTOME:R-DME-9013149", "REACTOME:R-HSA-8876198", "REACTOME:R-HSA-9013149", "REACTOME:R-MMU-8876198", "REACTOME:R-MMU-9013149", "REACTOME:R-RNO-8876198", "REACTOME:R-RNO-9013149" ]

9

[]

0

[ "PUB00014130", "PUB00080401", "PUB00080402", "PUB00080403", "PUB00080404", "PUB00113073", "PUB00113086", "PUB00160270", "PUB00160271", "PUB00160272", "PUB00160482", "PUB00160483" ]

[ "14594214", "22728242", "17233582", "15766521", "15493994", "17981578", "21937428", "15388334", "16473597", "17239822", "15033976", "25309324" ]

[ "Membrane targeting by pleckstrin homology domains.", "Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.", "Pleckstrin homology (PH) domains and phosphoinositides.", "Pleckstrin homology domains: two halves make a hole?", "Pleckstrin homology domains: not ju...

[ 2004, 2012, 2007, 2005, 2004, 2008, 2011, 2004, 2005, 2007, 2004, 2014 ]

12

[]

0

null

[ "Opisthokonta" ]

[ 2653 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 1, 24, 3, 7 ]

5

true

Domain

Alsin-like, PH-like domain

Alsin-like_PH

4

IPR057249

57,249

Androglobin, circularly permuted globin domain

Globin_CP_ADGB

Domain

1,221

false

This entry represents the circularly permuted globin-like domain found in Androglobin. Androglobin is a multidomain protein with a key role in spermatogenesis. It is required for sperm flagellum formation and maturation of elongating spermatids, both essential for male fertility [ ]. Unlike classical globins, the andro...

[]

0

[ "PROFILE" ]

[ "PS52042" ]

[ "GLOBIN_CP_ADGB" ]

[ 1221 ]

1

[]

0

[]

0

[ "PUB00003401", "PUB00095962", "PUB00148334", "PUB00154403", "PUB00160213", "PUB00160273" ]

[ "3138426", "22115833", "24811692", "36995441", "35700329", "38725499" ]

[ "An evolutionary tree for invertebrate globin sequences.", "Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes.", "Function and evolution of vertebrate globins.", "ADGB variants cause asthenozoospermia and male infertility.", "Androglobin, a chimeric mammalian g...

[ 1988, 2012, 2014, 2023, 2022, 2024 ]

6

[]

0

null

[ "Opisthokonta" ]

[ 1221 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 5, 2, 5 ]

4

true

Domain

Androglobin, circularly permuted globin domain

Globin_CP_ADGB

1

IPR057250

57,250

Zinc finger C2HC, NPR-type

Znf_C2HC_NPR-type

Domain

2,933

false

This entry represents the C2HC zinc finger found in NPR1 and related proteins. The nonexpressor of pathogenesis-related genes 1 (NPR1) is a master regulator of the defence transcriptome induced by the plant immune signal salicylic acid (SA). It encodes a protein with two protein-protein interaction domains: a BTB/POZ d...

[]

0

[ "PROFILE" ]

[ "PS52046" ]

[ "ZF_C2HC_NPR" ]

[ 2933 ]

1

[]

0

[ "7mk2", "7mk3", "7tac", "7tad" ]

4

[ "PUB00160248", "PUB00160249", "PUB00160250" ]

[ "31783558", "35545668", "36934653" ]

[ "Genome-Wide Identification and Analysis of the NPR1-Like Gene Family in Bread Wheat and Its Relatives.", "Structural basis of NPR1 in activating plant immunity.", "Seeing is believing: Understanding functions of NPR1 and its paralogs in plant immunity through cellular and structural analyses." ]

[ 2019, 2022, 2023 ]

3

[]

0

null

[ "Embryophyta" ]

[ 2933 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 56, 14, 19 ]

3

true

Domain

Zinc finger C2HC, NPR-type

Znf_C2HC_NPR-type

1

IPR057251

57,251

FP protein, C-terminal domain

FP_C

Domain

5,283

false

This entry represents the C-terminal domain of the FP protein from Orgyia pseudotsugata multicapsid polyhedrosis virus, which is also found in other uncharacterised sequences predominantly from arthropods and baculovirus. The function of the FP protein is not known. The protein is missing in baculovirus FP (Few Polyhed...

[]

0

[ "PFAM" ]

[ "PF25298" ]

[ "Baculo_FP_2nd" ]

[ 5283 ]

1

[]

0

[]

0

[ "PUB00007230" ]

[ "8760443" ]

[ "Characterization of the Lymantria dispar nucleopolyhedrovirus 25K FP gene." ]

[ 1996 ]

1

[]

0

null

[ "Baculoviridae", "Eukaryota" ]

[ 134, 5149 ]

2

[]

0

true

Domain

FP protein, C-terminal domain

FP_C

5

IPR057252

57,252

Competence protein CoiA, C-terminal domain

CoiA_C

Domain

1,097

false

This entry represents a domain found C-terminal in the Competence protein CoiA from Bacillus subtilis and related proteins predominantly found in Bacilli. This domain is predicted to fold in a mainly α-helical structure. CoiA falls within a competence-specific operon in Streptococcus. It is required for optimal transfo...

[]

0

[ "PFAM" ]

[ "PF25166" ]

[ "CoiA_C" ]

[ 1097 ]

1

[]

0

[]

0

[ "PUB00052316", "PUB00081394" ]

[ "8901420", "17630974" ]

[ "Who's competent and when: regulation of natural genetic competence in bacteria.", "Multiple interactions among the competence proteins of Bacillus subtilis." ]

[ 1996, 2007 ]

2

[]

0

null

[ "Bacteria" ]

[ 1097 ]

1

[]

0

true

Domain

Competence protein CoiA, C-terminal domain

CoiA_C

3

IPR057253

57,253

Competence protein CoiA-like, N-terminal domain

CoiA-like_N

Domain

3,939

false

This domain is found N-terminal in the Competence protein CoiA from Bacillus subtilis, Druantia protein DruB from Escherichia coli, and related bacterial proteins. It contains three highly conserved cysteine and histidine residues that are probably involved in metal coordination. CoiA falls within a competence-specific...

[]

0

[ "PFAM" ]

[ "PF25164" ]

[ "CoiA_N" ]

[ 3939 ]

1

[]

0

[]

0

[ "PUB00052316", "PUB00081394", "PUB00097806" ]

[ "8901420", "17630974", "29371424" ]

[ "Who's competent and when: regulation of natural genetic competence in bacteria.", "Multiple interactions among the competence proteins of Bacillus subtilis.", "Systematic discovery of antiphage defense systems in the microbial pangenome." ]

[ 1996, 2007, 2018 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 13, 3880, 6, 2, 38 ]

5

[]

0

true

Domain

Competence protein CoiA-like, N-terminal domain

CoiA-like_N

7

IPR057254

57,254

Ubiquitin carboxyl-terminal hydrolase family 1, cysteine active-site

UCH_AS

Conserved_site

3,985

false

This entry represents the Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. Ubiquitin carboxyl-terminal hydrolases (EC 3.4.19.12) (UCH) (deubiquitinating enzymes) [ , ] are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved...

[]

0

[ "PROSITE" ]

[ "PS00140" ]

[ "UCH_1" ]

[ 3985 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-BTA-5689603", "R-BTA-8866652", "R-BTA-8951664", "R-DME-5689603", "R-DME-8866652", "R-DME-8951664", "R-HSA-5689603", "R-HSA-8866652", "R-HSA-8951664", "R-MMU-5689603", "R-MMU-8866652", "R-MMU-8951664", "R-RNO-5689603", "R-RNO-8866652", "R-RNO-8951664", "R-SCE-5689603",...

[ "EC:3.4.19.12", "REACTOME:R-BTA-5689603", "REACTOME:R-BTA-8866652", "REACTOME:R-BTA-8951664", "REACTOME:R-DME-5689603", "REACTOME:R-DME-8866652", "REACTOME:R-DME-8951664", "REACTOME:R-HSA-5689603", "REACTOME:R-HSA-8866652", "REACTOME:R-HSA-8951664", "REACTOME:R-MMU-5689603", "REACTOME:R-MMU-88...

23

[ "1cmx", "1uch", "1xd3", "2etl", "2len", "3ifw", "3irt", "3kvf", "3kw5", "4dm9", "4jkj", "6isu", "6qml", "7en4", "7yv4", "7zm0", "8dy8", "8ede", "8pw1", "8xi7", "9o4m" ]

21

[ "PUB00000623", "PUB00001008", "PUB00001305", "PUB00002419", "PUB00003577", "PUB00004632", "PUB00011704", "PUB00020025", "PUB00030423", "PUB00076953" ]

[ "1647207", "9827704", "9233788", "3015923", "7845226", "3031653", "11517925", "9891971", "14725770", "7044372" ]

[ "Genetic analysis of the ubiquitin system.", "Deubiquitinating enzymes: a new class of biological regulators.", "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.", "Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of...

[ 1991, 1998, 1997, 1986, 1994, 1987, 2001, 1998, 2004, 1982 ]

10

[]

0

null

[ "Eukaryota" ]

[ 3985 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 3, 10, 6, 14, 1, 1 ]

7

true

Conserved_site

Ubiquitin carboxyl-terminal hydrolase family 1, cysteine active-site

UCH_AS

8

IPR057255

57,255

P5A-ATPase, transmembrane helical hairpin

2TM_P5A-ATPase

Domain

4,086

false

This entry represents a domain found in homologues of endoplasmic reticulum P5A-ATPase (Spf1 in yeast; ATP13A1 in humans). It consists of two transmembrane helices that form a helical hairpin. This domain seems to be loosely associated with the core transmembrane domain [ ]. P5A-ATPase acts as a dislocase that mediates...

[]

0

[ "PFAM" ]

[ "PF23143" ]

[ "2TM_P5A-ATPase" ]

[ 4086 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.4.2.-", "PWY-6409", "PWY-8419", "R-CEL-936837", "R-HSA-936837", "R-MMU-936837", "R-SCE-936837", "R-SPO-936837" ]

[ "EC:7.4.2.-", "METACYC:PWY-6409", "METACYC:PWY-8419", "REACTOME:R-CEL-936837", "REACTOME:R-HSA-936837", "REACTOME:R-MMU-936837", "REACTOME:R-SCE-936837", "REACTOME:R-SPO-936837" ]

8

[ "6xmp", "6xmq", "6xms", "6xmt", "6xmu", "8op3", "8op4", "8op5", "8op6", "8op7", "8op8", "9jbm", "9jbz" ]

13

[ "PUB00094240", "PUB00096637", "PUB00101910", "PUB00151055", "PUB00151056", "PUB00151057" ]

[ "19762559", "32973005", "33310703", "34715013", "34172751", "34715014" ]

[ "Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.", "The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.", "ATP13A3 is a major component of the enigmatic mammalian polyamine transport sys...

[ 2010, 2020, 2021, 2021, 2021, 2021 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4086 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 2, 1, 2, 1, 3, 3, 1, 1, 7 ]

12

true

Domain

P5A-ATPase, transmembrane helical hairpin

2TM_P5A-ATPase

6

IPR057256

57,256

MtfA, enterobacterales

MtfA_enterob

Family

1,188

false

This entry represents Mlc titration factor A (MtfA, previously known as YeeI), which is found mainly in Enterobacteriaceae. Mlc titration factor A (MtfA, previously known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation ...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01593", "NF011939" ]

[ "MtfA", "PRK15410.1" ]

[ 1080, 1188 ]

2

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "3dl1", "3khi" ]

2

[ "PUB00054592", "PUB00066805" ]

[ "16855233", "22178967" ]

[ "YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12.", "Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12." ]

[ 2006, 2012 ]

2

[ "IPR010384" ]

[]

1

0

1

[ "Acyrthosiphon pisum", "Pseudomonadota" ]

[ 1, 1187 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MtfA, enterobacterales

MtfA_enterob

4

IPR057257

57,257

Small ribosomal subunit protein cS23

Ribosomal_cS23

Family

602

false

This entry describes probable ribosomal proteins or ribosome-associated proteins mostly found in cyanobacteria and some species from red and green algae. In cyanobacteria, the small ribosomal subunit protein cS23 is named Ycf65. In red algae, the gene encoding this protein is Ycf65 [ ]. Plastid-specific ribosomal prote...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00619", "NF002740" ]

[ "Ribosomal_plastid_cS23", "PRK02724.1" ]

[ 594, 572 ]

2

[]

0

[ "2kt9" ]

1

[ "PUB00008661", "PUB00160304" ]

[ "10874039", "12605670" ]

[ "The plastid ribosomal proteins. Identification of all the proteins in the 30 S subunit of an organelle ribosome (chloroplast).", "Proteomic identification of all plastid-specific ribosomal proteins in higher plant chloroplast 30S ribosomal subunit." ]

[ 2000, 2003 ]

2

[ "IPR006924" ]

[]

1

0

1

[ "Cyanobacteriota", "Eukaryota" ]

[ 359, 243 ]

2

[]

0

true

Family

Small ribosomal subunit protein cS23

Ribosomal_cS23

6

IPR057259

57,259

Ribosomal protein L19e, N-terminal domain

Ribosomal_L19e

Domain

7,123

false

This domain is found at the N-terminal end of the large ribosomal subunit protein eL19 found in eukaryotes and archaea. This is an α-helical domain that assumes an orthogonal bundle topology.

[]

0

[ "PFAM" ]

[ "PF01280" ]

[ "Ribosomal_L19e" ]

[ 7123 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-CFA-156827", "R-CFA-1799339", "R-CFA-6791226", "R-CFA-72689", "R-CFA-727...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

76

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

656

[ "PUB00038013", "PUB00052115", "PUB00061415", "PUB00106464", "PUB00160178" ]

[ "15334087", "19362093", "19738021", "22306461", "19933108" ]

[ "Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.", "U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.", "Structures of triacetyloleandomycin and mycalamide A bi...

[ 2004, 2009, 2009, 2012, 2009 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 943, 4, 6141, 35 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 10, 3, 1, 4, 6, 2, 2, 17 ]

12

true

Domain

Ribosomal protein L19e, N-terminal domain

Ribosomal_L19e

9

IPR057260

57,260

Ribosomal protein L19e, C-terminal domain

Ribosomal_L19e_C

Domain

7,415

false

This domain is found at the C-terminal end of the large ribosomal subunit protein eL19 found in eukaryotes and archaea. This is an α-helical domain that assumes an orthogonal bundle topology.

[]

0

[ "PFAM" ]

[ "PF25476" ]

[ "Ribosomal_L19e_C" ]

[ 7415 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-CFA-156827", "R-CFA-1799339", "R-CFA-6791226", "R-CFA-72689", "R-CFA-727...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

76

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

657

[ "PUB00038013", "PUB00052115", "PUB00061415", "PUB00106464", "PUB00160178" ]

[ "15334087", "19362093", "19738021", "22306461", "19933108" ]

[ "Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.", "U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.", "Structures of triacetyloleandomycin and mycalamide A bi...

[ 2004, 2009, 2009, 2012, 2009 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 948, 2, 6429, 36 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 1, 1, 1, 7, 3, 1, 5, 11, 2, 2, 18 ]

12

true

Domain

Ribosomal protein L19e, C-terminal domain

Ribosomal_L19e_C

7

IPR057261

57,261

Sororin-like, middle region

Sororin-like_M

Domain

530

false

This entry represents the middle region of Sororin and related animal proteins. According to structure predictions, this region is likely disordered. Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion [ , ]. The protein is nuclear in interphase cells, dispersed from the chromatin in mit...

[]

0

[ "PFAM" ]

[ "PF09666" ]

[ "Sororin_middle" ]

[ 530 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2467813", "R-HSA-2468052", "R-HSA-2500257", "R-MMU-2467813", "R-MMU-2468052", "R-MMU-2500257" ]

[ "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2468052", "REACTOME:R-HSA-2500257", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2468052", "REACTOME:R-MMU-2500257" ]

6

[]

0

[ "PUB00044494", "PUB00045133", "PUB00158890" ]

[ "15837422", "17349791", "38830897" ]

[ "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.", "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.", "Sororin is an evolutionary conserved antagonist of WAPL." ]

[ 2005, 2007, 2024 ]

3

[]

0

null

[ "Bilateria" ]

[ 530 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 1, 5 ]

5

true

Domain

Sororin-like, middle region

Sororin-like_M

4

IPR057262

57,262

Connectase MJ0548-like, N-terminal domain

MJ0548_N

Domain

148

false

This domain is found at the N-terminal end of Connectase MJ0548 from Methanocaldococcus jannaschii and similar archaeal sequences. MJ0548 is a distant, monomeric proteasome homologue which connects proteins in a sequence-specific manner [ ].

[]

0

[ "PFAM" ]

[ "PF09894" ]

[ "MJ0548_N" ]

[ 148 ]

1

[]

0

[ "6zvz", "6zw0", "8jtu", "8wkd" ]

4

[ "PUB00158988" ]

[ "33688044" ]

[ "Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits." ]

[ 2021 ]

1

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 145, 3 ]

2

[]

0

true

Domain

Connectase MJ0548-like, N-terminal domain

MJ0548_N

1

IPR057263

57,263

C-terminal of Roc, COR-B domain

COR-B

Domain

4,268

false

This entry corresponds to COR-B, located at the C-terminal of COR. COR-B serves as the main dimerisation interface in the full-length LRRK2 structure [ ]. It interacts with the kinase domain, which is essential for LRRK2 kinase activity [ ]. COR-B consists of four flanked helices, a central seven-stranded antiparallel ...

[]

0

[ "PFAM" ]

[ "PF25497" ]

[ "COR-B" ]

[ 4268 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-DDI-1483248", "R-DDI-1632852", "R-DDI-1660499", "R-DDI-1660516", "R-DDI-1660517", "R-DDI-5675482", "R-DDI-8876198", "R-HSA-8857538", "R-MMU-8857538" ]

[ "EC:2.7.11.1", "REACTOME:R-DDI-1483248", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-1660499", "REACTOME:R-DDI-1660516", "REACTOME:R-DDI-1660517", "REACTOME:R-DDI-5675482", "REACTOME:R-DDI-8876198", "REACTOME:R-HSA-8857538", "REACTOME:R-MMU-8857538" ]

10

[ "3dpt", "3dpu", "6hlu", "6vno", "6vp6", "6vp7", "6vp8", "6xr4", "7lht", "7lhw", "7li3", "7li4", "8e04", "8e05", "8e06", "8fac", "8fo2", "8fo7", "8fo8", "8fo9", "8r4b", "8r4c", "8r4d", "8smc", "8txz", "8tyq", "8tzb", "8tzc", "8tze", "8tzf", "8tzg", "8tzh"...

42

[ "PUB00050311", "PUB00051458", "PUB00124639", "PUB00160124", "PUB00160125", "PUB00160280" ]

[ "18230735", "18650931", "18523161", "32814344", "37189360", "30609797" ]

[ "Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.", "Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.", "The Roco protein family: a functional perspective.", "Structure o...

[ 2008, 2008, 2008, 2020, 2023, 2019 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinales", "metagenomes" ]

[ 651, 3583, 29, 5 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 5, 1, 13, 7, 3, 1, 4 ]

7

true

Domain

C-terminal of Roc, COR-B domain

COR-B

3

IPR057264

57,264

Large ribosomal subunit protein uL24, C-terminal domain

Ribosomal_uL24_C

Domain

27,626

false

This entry describes the C-terminal domain in large ribosomal subunit protein uL24 (also known as RPL26). RPL26 is one of the proteins from the large ribosomal subunit. In their mature form, these proteins have 103 to 150 amino-acid residues. RPL26 makes a very minor contributions to the biogenesis, structure, and func...

[]

0

[ "PFAM" ]

[ "PF17136" ]

[ "ribosomal_L24" ]

[ 27626 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-54192...

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOM...

21

[ "1nkw", "1nwx", "1nwy", "1sm1", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xbp", "2d3o", "2ftc", "2j28", "2rdo", "2vrh", "2zjp", "2zjq", "2zjr", "3bbx", "3cf5", "3dll", "3iy9", "3j3v", "3j3w", "3j45", "3j46", "3j5l", "3j7y", "3j7z", "3j8g", "3j9m", "3j9w"...

1,252

[ "PUB00092170", "PUB00092171", "PUB00092172" ]

[ "22688513", "16213212", "338913" ]

[ "Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function.", "Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.", "Assembly in vitro of the 50 S subunit from Escherichia coli ribosomes: proteins essential for the first ...

[ 2012, 2005, 1977 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23578, 3626, 422 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 1, 1, 1, 2, 1, 7, 3, 7 ]

10

true

Domain

Large ribosomal subunit protein uL24, C-terminal domain

Ribosomal_uL24_C

4

IPR057265

57,265

Large ribosomal subunit protein uL22, archaea

Ribosomal_uL22_arc

Family

3,491

false

This family describes the ribosomal protein uL22, previously known as L17 and L22. Proteins in this entry are found in archaea, animals and plants. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This l...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01331_A", "NF003260" ]

[ "Ribosomal_uL22_A", "PRK04223.1" ]

[ 3091, 3289 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DME-156827", "R-DME-1799339", "R-DME-72689", "R-DME-72706", "R-DME-975956", "R-DME-975957", "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-679...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-975956", "REACTOME:R-CEL-975957", "REACTOME:R-DME-156827", "REACTOME:R-DME-1799339", "REACTOME:R-DME-72689", "REACTOME:R-DME-72706", "REACTOME:R-DME-975956", "REACTOME:R-DME-97595...

39

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

335

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR005721" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "Pantoea vagans", "unclassified sequences" ]

[ 870, 2595, 1, 25 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 1, 2, 6, 4, 4, 5, 13 ]

9

true

Family

Large ribosomal subunit protein uL22, archaea

Ribosomal_uL22_arc

4

IPR057266

57,266

Large ribosomal subunit protein uL5, eukaryota/archaea

Ribosomal_uL5_euk_arc

Family

6,316

false

This entry represents uL5 proteins primarily found in eukaryotic and archaeal organisms. Large ribosomal subunit protein uL5, previously known as Ribosomal protein L5, is ~180 amino acids in length. In Escherichia coli, uL5 is known to be involved in binding 5S RNA to the large ribosomal subunit [ ]. Ribosomes are the ...

[]

0

[ "NCBIFAM" ]

[ "NF003258" ]

[ "PRK04219.1" ]

[ 6316 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", "R-DME-156827", "R-DME-1799339", "R-DME-72689", "R-DME-72706", "R-DME-975956", "R-DME-975957...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-975956", "REACTOME:R-CEL-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-1799339", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72706", "REACTOME:R-DDI-975956", "REACTOME:R-DDI-97595...

57

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp"...

636

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00104042" ]

[ "11297922", "11290319", "11114498", "11866091" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "On the interaction of ribosomal protein L5 with 5S rRNA." ]

[ 2001, 2001, 2000, 2002 ]

4

[ "IPR002132" ]

[ "IPR022804" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 937, 3, 5343, 33 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 2, 1, 2, 4, 3, 1, 7, 5, 2, 2, 14 ]

12

true

Family

Large ribosomal subunit protein uL5, eukaryota/archaea

Ribosomal_uL5_euk_arc

6

IPR057268

57,268

Large ribosomal subunit protein uL18

Ribosomal_L18

Family

37,085

false

This entry describes the family large subunit ribosomal protein uL18 found in eukaryotes and prokaryotes. The large ribosomal subunit protein uL18 is an essential component of the large subunit LSU, which is required in its formation and stabilisation. The LSU contains the ribosomal catalytic site termed the peptidyl t...

[]

0

[ "CDD" ]

[ "cd00432" ]

[ "Ribosomal_L18_L5e" ]

[ 37085 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-5389840", "R-BTA-5419276", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-BTA-9937383", "R-CEL-156827", "R-CEL-1799339", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-...

82

[ "1ffk", "1ily", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1nkw", "1nwx", "1nwy", "1ovy", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1sm1", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9"...

1,841

[ "PUB00002952", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00026057", "PUB00028498", "PUB00029613", "PUB00030943", "PUB00070729", "PUB00079483", "PUB00079484", "PUB00079485", "PUB00097818", "PUB00113296" ]

[ "8626719", "11297922", "11290319", "11114498", "11964156", "10937989", "14687565", "15184028", "17198710", "10937990", "11470155", "14527328", "12962325", "10529214" ]

[ "Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "The solution structure of ribosomal protein L18 from Thermus ...

[ 1996, 2001, 2001, 2000, 2002, 2000, 2004, 2004, 2007, 2000, 2001, 2003, 2003, 1999 ]

14

[]

[ "IPR005484", "IPR005485" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 946, 23702, 11984, 453 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 28, 2, 5, 5, 1, 10, 7, 1, 26, 8, 1, 2, 43 ]

13

true

Family

Large ribosomal subunit protein uL18

Ribosomal_L18

6

IPR057270

57,270

Uncharacterized protein YcgB-like

Ycgb-like

Family

5,236

false

This entry represents a group of proteins mainly found in proteobacteria, including YcgB, an uncharacterised protein first described in Escherichia coli (strain K12) [ ] [ ]. YcgB has been suggested to be part of a conserved signalling pathway with YeaH and YeaG. This pathway may be involved in nitrogen metabolism (see...

[]

0

[ "NCBIFAM" ]

[ "NF008737" ]

[ "PRK11767.1" ]

[ 5236 ]

1

[]

0

[]

0

[ "PUB00009937", "PUB00010122", "PUB00019289", "PUB00093610" ]

[ "8144469", "8982457", "8905232", "29769716" ]

[ "Cloning and characterization of spoVR, a gene from Bacillus subtilis involved in spore cortex formation.", "Molecular genetics of sporulation in Bacillus subtilis.", "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.", "Mutant phenotypes f...

[ 1994, 1996, 1996, 2018 ]

4

[ "IPR007390" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured marine phage" ]

[ 5209, 4, 22, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterized protein YcgB-like

Ycgb-like

8

IPR057271

57,271

YagK/YfjJ, C-terminal domain

YagK_YfjJ_C

Domain

3,248

false

This domain is found at the C-terminal end of a group of uncharacterised proteins from bacteria, such as YagK and YfjJ from E.coli. This domain is structurally similar to viral Rep proteins and bacterial relaxases based on structure predictions and comparison, containing also the conserved HXH motif typically found in ...

[]

0

[ "PFAM" ]

[ "PF11726" ]

[ "YagK_YfjJ_C" ]

[ 3248 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina mazei", "Opisthokonta", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 3220, 1, 4, 2, 21 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

YagK/YfjJ, C-terminal domain

YagK_YfjJ_C

4

IPR057272

57,272

Piwi domain, nematodes

Piwi_nem

Domain

249

false

This entry describes the Piwi domain mainly found in nematodes. This domain corresponds to the C-terminal portion of Argonaute proteins, which are involved in RNA silencing. The Piwi domain consists of two subdomains, one of which provides the 5' anchoring of the guide RNA and the other, the catalytic site for slicing....

[]

0

[ "CDD" ]

[ "cd02826" ]

[ "Piwi-like" ]

[ 249 ]

1

[]

0

[ "1u04", "1w9h", "1ytu", "1z25", "1z26", "2bgg", "2w42", "6t5t", "6tuo", "6xu0", "6xup", "8jpx", "8ok9", "8pvv", "8qg0" ]

15

[ "PUB00018283", "PUB00020128", "PUB00035384", "PUB00035781", "PUB00098357", "PUB00116039" ]

[ "11050429", "15284453", "16216572", "16691418", "16434185", "17029813" ]

[ "Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain.", "Crystal structure of Argonaute and its implications for RISC slicer activity.", "Structure and function of argonaute proteins.", "On the origin and functions of RNA-mediated silencing: fr...

[ 2000, 2004, 2005, 2006, 2006, 2006 ]

6

[ "IPR003165" ]

[]

1

0

1

[ "Chromadorea", "Methanobacteriota" ]

[ 243, 6 ]

2

[ "Caenorhabditis elegans" ]

[ 10 ]

1

true

Domain

Piwi domain, nematodes

Piwi_nem

8

IPR057273

57,273

Ddi1/2, HDD domain

Ddi1/2_HDD

Domain

2,440

false

This domain is found in the human DNA-damage-inducible homologs 1 and 2 (hDdi1, hDdi2) and related proteins. hDdi2 is a member of the Ddi1-like protein family, which is intricately connected to the UBQ-proteasome. The better-studied yeast homologue Ddi1 (yDdi1) has been implicated in cell cycle regulation, DNA damage r...

[]

0

[ "PFAM" ]

[ "PF24669" ]

[ "Ddi2_HDD" ]

[ 2440 ]

1

[ "EC" ]

[ "3.4.23.-" ]

[ "EC:3.4.23.-" ]

1

[ "5k57" ]

1

[ "PUB00108835" ]

[ "27461074" ]

[ "Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2440 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 3, 1, 6, 5, 2, 5 ]

6

true

Domain

Ddi1/2, HDD domain

Ddi1/2_HDD

5

IPR057274

57,274

Crescentin, N-terminal domain

CreS_N

Domain

15

false

This entry represents the short N-terminal domain of intermediate filament-like cell shape determinant crescentin (CreS) found in caulobacterales. According to structure predictions, this domain adopts an α-helical configuration. CreS is the bacterial equivalent to Intermediate Filament (IF) proteins from eukaryotes. I...

[]

0

[ "PFAM" ]

[ "PF25217" ]

[ "CreS_N" ]

[ 15 ]

1

[]

0

[ "8afe", "8afh", "8afl", "8afm", "8ahl", "8aia", "8aix", "8ajb" ]

8

[ "PUB00094433", "PUB00094434", "PUB00094435", "PUB00158884" ]

[ "14675535", "21360832", "26024016", "38324567" ]

[ "The bacterial cytoskeleton: an intermediate filament-like function in cell shape.", "The domain organization of the bacterial intermediate filament-like protein crescentin is important for assembly and function.", "Polyphyly of nuclear lamin genes indicates an early eukaryotic origin of the metazoan-type inter...

[ 2003, 2011, 2015, 2024 ]

4

[]

0

null

[ "Alphaproteobacteria" ]

[ 15 ]

1

[]

0

true

Domain

Crescentin, N-terminal domain

CreS_N

6

IPR057275

57,275

GLAA-B, beta-barrel domain I

Beta-barrel_GLAA-B_I

Domain

894

false

This entry represents the first β-barrel domain found towards the N terminus of Alpha-1,3-galactosidase A-B (GLAA-B) from bacteria. These proteins share a domain architecture consisting of a core β-helix surrounded by two small β-barrel domains (domains I and II), which are involved in protein dimerisation [ ]. GLAA-B ...

[]

0

[ "PFAM" ]

[ "PF23763" ]

[ "Beta-barrel_GLAA-B_I" ]

[ 894 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.22", "PWY-6527" ]

[ "EC:3.2.1.22", "METACYC:PWY-6527" ]

2

[ "8pvs", "9beh", "9bev", "9i4f", "9i4g" ]

5

[ "PUB00155512", "PUB00155513" ]

[ "18227066", "33127644" ]

[ "Identification of a GH110 subfamily of alpha 1,3-galactosidases: novel enzymes for removal of the alpha 3Gal xenotransplantation antigen.", "The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens." ]

[ 2008, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA382M17", "metagenomes" ]

[ 876, 9, 1, 8 ]

4

[]

0

true

Domain

GLAA-B, beta-barrel domain I

Beta-barrel_GLAA-B_I

1

IPR057276

57,276

Thermus phage P23-45 gp39, N-terminal

P23-45_gp39_N

Domain

2

false

This domain is found at the N-terminal in the protein gp35 from Thermus phage P23-45 and similar sequences from tailed bacteriophages. This protein binds the host's DNA-dependent RNA polymerase (RNAP), inhibiting host gene transcription while allowing transcription of phage genes. Structural studies show this core doma...

[]

0

[ "PFAM" ]

[ "PF20760" ]

[ "P23-45_gp39_N" ]

[ 2 ]

1

[]

0

[ "3wod", "3woe", "3wof", "5xj0" ]

4

[ "PUB00151615", "PUB00151616" ]

[ "24589779", "29165680" ]

[ "Structural basis for promoter specificity switching of RNA polymerase by a phage factor.", "A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation." ]

[ 2014, 2018 ]

2

[]

0

null

[ "Oshimavirus" ]

[ 2 ]

1

[]

0

true

Domain

Thermus phage P23-45 gp39, N-terminal

P23-45_gp39_N

7

IPR057277

57,277

Secreted LysM effector LysM, C-terminal domain

LysM_C

Domain

396

false

This domain is found at the C-terminal end of Secreted LysM effector LysM3, 6, 9 and 14 from Penicillium expansum, which might have a role in sequestration of chitin oligosaccharides to dampen host defence [ ]. This domain is predicted to have a mainly β configuration.

[]

0

[ "PFAM" ]

[ "PF25139" ]

[ "LysM14_C" ]

[ 396 ]

1

[]

0

[]

0

[ "PUB00154508" ]

[ "32656702" ]

[ "Multiple transcriptomic analyses and characterization of pathogen-related core effectors and LysM family members reveal their differential roles in fungal growth and pathogenicity in Penicillium expansum." ]

[ 2020 ]

1

[]

0

null

[ "leotiomyceta" ]

[ 396 ]

1

[]

0

true

Domain

Secreted LysM effector LysM, C-terminal domain

LysM_C

1

IPR057279

57,279

MGAT4, conserved region

MGAT4

Domain

7,131

false

This entry represents the conserved region found in N-acetylglucosaminyltransferase IV (MGAT4, also known as GnT-IV) and related proteins. N-acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI...

[]

0

[ "PFAM" ]

[ "PF04666" ]

[ "MGAT4_cons" ]

[ 7131 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.145", "PWY-7426", "R-BTA-381426", "R-BTA-8957275", "R-BTA-975577", "R-DRE-975577", "R-GGA-381426", "R-GGA-8957275", "R-GGA-975577", "R-HSA-381426", "R-HSA-8957275", "R-HSA-9694548", "R-HSA-975577", "R-MMU-381426", "R-MMU-8957275", "R-MMU-975577", "R-RNO-381426", "R-RNO-89572...

[ "EC:2.4.1.145", "METACYC:PWY-7426", "REACTOME:R-BTA-381426", "REACTOME:R-BTA-8957275", "REACTOME:R-BTA-975577", "REACTOME:R-DRE-975577", "REACTOME:R-GGA-381426", "REACTOME:R-GGA-8957275", "REACTOME:R-GGA-975577", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-9694548", "R...

23

[]

0

[ "PUB00008526", "PUB00015209", "PUB00155740", "PUB00160023", "PUB00160153", "PUB00160154" ]

[ "9278430", "12691742", "35854001", "10372966", "20015870", "10962001" ]

[ "Purification and characterization of UDP-N-acetylglucosamine: alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase-IV) from bovine small intestine.", "An evolving hierarchical family classification for glycosyltransferases.", "Discovery of a lectin domain that regulates...

[ 1997, 2003, 2022, 1998, 2010, 2000 ]

6

[]

0

null

[ "Eukaryota" ]

[ 7131 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 5, 18, 12, 25 ]

5

true

Domain

MGAT4, conserved region

MGAT4

1

IPR057281

57,281

REST-like, C2H2-type zinc finger

Zfn-C2H2_REST

Domain

1,169

false

This entry represents a C2H2-type zinc finger found in human RE1-silencing transcription factor (REST) and similar sequences from vertebrates. REST is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells [ , , ].

[]

0

[ "PFAM" ]

[ "PF24540" ]

[ "zf-C2H2_REST" ]

[ 1169 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3214815", "R-HSA-8943724", "R-HSA-9031628", "R-HSA-9679191", "R-HSA-9768777", "R-MMU-3214815", "R-RNO-3214815" ]

[ "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-8943724", "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-9679191", "REACTOME:R-HSA-9768777", "REACTOME:R-MMU-3214815", "REACTOME:R-RNO-3214815" ]

7

[ "2dmd" ]

1

[ "PUB00066590", "PUB00155933", "PUB00155934" ]

[ "12399542", "10449787", "11779185" ]

[ "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.", "CoREST: a functional corepressor required for regulation of neural-specific gene expression.", "REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation." ]

[ 2002, 1999, 2002 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 1169 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 13, 3, 5 ]

4

true

Domain

REST-like, C2H2-type zinc finger

Zfn-C2H2_REST

5

IPR057282

57,282

RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain

RETREG1-3-like_RHD

Domain

4,824

false

This entry represents the N-terminal reticulon-homology domain (RHD) of Reticulophagy regulator 1-3 (RETREG1-3), ARL-6 -interacting protein 1 (ARL6IP) and similar animal sequences. These proteins are regulators involved in endoplasmic reticulum tubulation that have been associated with diverse neurological diseases [ ,...

[]

0

[ "PFAM" ]

[ "PF24456" ]

[ "RHD_RETREG1-3" ]

[ 4824 ]

1

[]

0

[]

0

[ "PUB00101519", "PUB00155827", "PUB00155828" ]

[ "24262037", "37225994", "28471035" ]

[ "Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.", "Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.", "ARL6IP1 mutation causes congenital insensitivity to pain, acromutilation and spastic paraplegia." ]

[ 2014, 2023, 2018 ]

3

[]

[ "IPR055255", "IPR055257", "IPR055258" ]

0

3

0

[ "Eukaryota" ]

[ 4824 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 2, 26, 17, 18 ]

5

true

Domain

RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain

RETREG1-3-like_RHD

3

IPR057283

57,283

RGF3, winged helix domain

RGF3_WH

Domain

1,189

false

This entry represents a winged helix domain found in Rho1 guanine nucleotide exchange factors RGF3 and TUS1 from fission and baker's yeast and related proteins. Both RGF3 and TUS1 stimulate the exchange of Rho1 GDP-bound form into GTP-bound form [ , , ]. RGF3 was found to regulate the beta-1,3-glucan biosynthesis and c...

[]

0

[ "PFAM" ]

[ "PF23582" ]

[ "WHD_RGF3" ]

[ 1189 ]

1

[]

0

[]

0

[ "PUB00155919", "PUB00155920", "PUB00155921" ]

[ "16291723", "11839800", "15546915" ]

[ "Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p.", "Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.", "Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynt...

[ 2005, 2002, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1189 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Domain

RGF3, winged helix domain

RGF3_WH

2

IPR057284

57,284

Rho GTPase-activating protein 35-like, FF domain

FF_RHG35_4th

Domain

3,032

false

This domain is found in Rho GTPase-activating protein 35 from Rattus norvegicus (RHG35) and similar animal sequences. RHG35 is involved in cell differentiation, cell adhesion and migration, retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogen...

[]

0

[ "PFAM" ]

[ "PF23083" ]

[ "FF_RHG35_4th" ]

[ 3032 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-416550", "R-CFA-8849471", "R-CFA-8980692", "R-CFA-9013026", "R-CFA-9013106", "R-CFA-9013148", "R-CFA-9013149", "R-CFA-9013404", "R-CFA-9013405", "R-CFA-9013406", "R-CFA-9013408", "R-CFA-9013409", "R-CFA-9013423", "R-CFA-9696264", "R-CFA-9696270", "R-CFA-9696273", "R-DME-350407...

[ "REACTOME:R-CFA-416550", "REACTOME:R-CFA-8849471", "REACTOME:R-CFA-8980692", "REACTOME:R-CFA-9013026", "REACTOME:R-CFA-9013106", "REACTOME:R-CFA-9013148", "REACTOME:R-CFA-9013149", "REACTOME:R-CFA-9013404", "REACTOME:R-CFA-9013405", "REACTOME:R-CFA-9013406", "REACTOME:R-CFA-9013408", "REACTOME...

77

[]

0

[ "PUB00117458", "PUB00160288" ]

[ "9852136", "20439493" ]

[ "The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain.", "Extracellular signal-regulated kinase promotes Rho-dependent focal adhesion formation by suppressing p190A RhoGAP." ]

[ 1998, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3032 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 6, 5, 5, 6 ]

5

true

Domain

Rho GTPase-activating protein 35-like, FF domain

FF_RHG35_4th

2

IPR057285

57,285

RNA cytosine-C(5)-methyltransferase NSUN2-like, pre-PUA domain

Pre-PUA_NSUN2

Domain

5,377

false

This domain is found in RNA cytosine C(5)-methyltransferase NSUN2 from animals, multisite-specific tRNA:(cytosine-C(5))- methyltransferase (Trm4) from yeast and related eukaryotic proteins. This domain has detectable similarity to known pre-PUA domains and it is predicted to adopt similar structure. NSUN2 is an RNA cyt...

[]

0

[ "PFAM" ]

[ "PF25376" ]

[ "Pre-PUA_NSUN2" ]

[ 5377 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.1.1.-", "2.1.1.203", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601...

[ "EC:2.1.1.-", "EC:2.1.1.203", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729"...

148

[]

0

[ "PUB00054131", "PUB00160167", "PUB00160168" ]

[ "10445884", "17071714", "22995836" ]

[ "Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme.", "Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (C...

[ 1999, 2006, 2012 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5377 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 4, 2, 1, 1, 3, 1, 6, 5, 1, 2, 22 ]

12

true

Domain

RNA cytosine-C(5)-methyltransferase NSUN2-like, pre-PUA domain

Pre-PUA_NSUN2

5

IPR057286

57,286

RNA cytosine-C(5)-methyltransferase NSUN2-like, PUA domain

PUA_NSUN2

Domain

4,902

false

This domain is found in RNA cytosine C(5)-methyltransferase NSUN2 from animals, multisite-specific tRNA:(cytosine-C(5))- methyltransferase (Trm4) from yeast and related eukaryotic proteins. NSUN2 is an RNA cytosine C5-methyltransferase that methylates cytosine to 5-methylcytosine in various RNAs, such as tRNAs, mRNAs a...

[]

0

[ "PFAM" ]

[ "PF25378" ]

[ "PUA_NSUN2" ]

[ 4902 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.1.1.-", "2.1.1.203", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601...

[ "EC:2.1.1.-", "EC:2.1.1.203", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729"...

148

[]

0

[ "PUB00054131", "PUB00160167", "PUB00160168" ]

[ "10445884", "17071714", "22995836" ]

[ "Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme.", "Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (C...

[ 1999, 2006, 2012 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4902 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 4, 2, 1, 1, 3, 1, 6, 5, 1, 2, 20 ]

12

true

Domain

RNA cytosine-C(5)-methyltransferase NSUN2-like, PUA domain

PUA_NSUN2

2

IPR057288

57,288

PLEKHM2, PH domain-like

PH_PLEKHM2

Domain

4,306

false

This entry represents one or two PH domains found in the PLEKHM2 and related proteins. This domain does not appear to be found in the PLEKHM1 proteins.

[]

0

[ "PFAM" ]

[ "PF23142" ]

[ "PH_PLEKHM2" ]

[ 4306 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-HSA-9013149", "R-HSA-9696264", "R-HSA-9696270", "R-MMU-6798695", "R-MMU-9013149", "R-MMU-9696264", "R-MMU-9696270", "R-RNO-9013149", "R-RNO-9696264", "R-RNO-9696270", "R-XTR-6798695" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-9013149", "REACTOME:R-MMU-9696264", "REACTOME:R-MMU-9696270", "REACTOME:R-RNO-9013149", "REACTOME:R-RNO-9696264", "REACTOME:R-RNO-9696270", "REACTOM...

12

[]

0

[ "PUB00102651" ]

[ "22172677" ]

[ "Arl8 and SKIP act together to link lysosomes to kinesin-1." ]

[ 2011 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4306 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 10, 8, 16 ]

6

true

Domain

PLEKHM2, PH domain-like

PH_PLEKHM2

6

IPR057289

57,289

Rab1/Ypt1

Family

7,297

false

This entry represents Rab1 and its yeast homologue Ypt1. Rab1 is found in eukaryotes and is a key regulatory component for the transport of vesicles from the ER to the Golgi apparatus [ , ]. Studies on mutations of Ypt1 showed that this protein is necessary for the budding of vesicles of the ER as well as for their tra...

[]

0

[ "CDD" ]

[ "cd01869" ]

[ "Rab1_Ypt1" ]

[ 7297 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-162658", "R-CFA-204005", "R-CFA-6807878", "R-CFA-6811434", "R-CFA-8873719", "R-CFA-8876198", "R-DDI-162658", "R-DDI-204005", "R-DDI-6798695", "R-DDI-6807878", "R-DDI-6811434", "R-DDI-6811438", "R-DDI-6811440", "R-DDI-8854214", "R-DDI-8873719", "R-DDI-8876198", "R-HSA-162658", ...

[ "REACTOME:R-CFA-162658", "REACTOME:R-CFA-204005", "REACTOME:R-CFA-6807878", "REACTOME:R-CFA-6811434", "REACTOME:R-CFA-8873719", "REACTOME:R-CFA-8876198", "REACTOME:R-DDI-162658", "REACTOME:R-DDI-204005", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811434", "REACTOME:R-...

47

[ "1ukv", "1yzn", "2bcg", "2fol", "2rhd", "2wwx", "3cue", "3jza", "3l0i", "3nkv", "3sfv", "3tkl", "4fmb", "4fmc", "4fmd", "4fme", "4hlq", "4i1o", "4iru", "4jvs", "5o74", "5szh", "5szk", "6sku", "7eq2", "7kmt", "8alk", "9mhf", "9mhg", "9mhh" ]

30

[ "PUB00028137", "PUB00056684", "PUB00099355", "PUB00114940", "PUB00114941", "PUB00114942", "PUB00160291" ]

[ "14576435", "11306556", "12189143", "16421253", "12788069", "11739271", "11879636" ]

[ "Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.", "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b.", "Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Yp...

[ 2003, 2001, 2002, 2006, 2003, 2001, 2002 ]

7

[ "IPR050227" ]

[]

1

0

1

[ "Eukaryota", "Terrestrivirus sp." ]

[ 7296, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 5, 1, 5, 11, 1, 7, 17, 1, 1, 19 ]

12

true

Family

Rab1/Ypt1

2

IPR057291

57,291

Cation/H(+) antiporter, central domain

CHX17_2nd

Domain

11,551

false

This entry represents the first domain of the C-terminal region of Cation/H(+) antiporter 17 from Arabidopsis thaliana (CHX17) and similar plant sequences. Plant Cation/H+ antiporters, also known as CHX-type antiporters, are involved in exchanging K+ or Na+ ions with protons (H+) across membranes. These transporters pl...

[]

0

[ "PFAM" ]

[ "PF23256" ]

[ "CHX17_2nd" ]

[ 11551 ]

1

[]

0

[]

0

[ "PUB00155588", "PUB00155589", "PUB00160365" ]

[ "15341627", "17133624", "32604959" ]

[ "Characterization of AtCHX17, a member of the cation/H+ exchangers, CHX family, from Arabidopsis thaliana suggests a role in K+ homeostasis.", "Arabidopsis thaliana CHX17 gene complements the kha1 deletion phenotypes in Saccharomyces cerevisiae.", "Diverse Physiological Functions of Cation Proton Antiporters ac...

[ 2004, 2006, 2020 ]

3

[]

0

null

[ "Eukaryota" ]

[ 11551 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 119, 1, 50, 44 ]

4

true

Domain

Cation/H(+) antiporter, central domain

CHX17_2nd

8

IPR057293

57,293

Ribonuclease R, second OB domain

RNR_OB2

Domain

466

false

This entry represents the second OB domain found in ribonuclease R (RNR) from bacteria. The function of this domain is unknown. Ribonuclease R proteins are 3'-5' exoribonucleases that release 5'-nucleoside monophosphates and are involved in maturation of structured RNAs [ ].

[]

0

[ "PFAM" ]

[ "PF24190" ]

[ "OB_RNR_2nd" ]

[ 466 ]

1

[]

0

[]

0

[ "PUB00080486", "PUB00155772" ]

[ "21135037", "19043582" ]

[ "Degradation of ribosomal RNA during starvation: comparison to quality control during steady-state growth and a role for RNase PH.", "Trans-translation in Helicobacter pylori: essentiality of ribosome rescue and requirement of protein tagging for stress resistance and competence." ]

[ 2011, 2008 ]

2

[]

0

null

[ "Pseudomonadati", "hydrothermal vent metagenome" ]

[ 451, 15 ]

2

[]

0

true

Domain

Ribonuclease R, second OB domain

RNR_OB2

6

IPR057295

57,295

Unkempt, zinc finger domain 4

UNK_Znf_4

Domain

3,312

false

This entry represents the fourth CCCH-type zinc finger found in RING finger protein Unkempt (UNK). Unkempt is an evolutionary conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology [ ]. It carries six CCCH zinc fingers ...

[]

0

[ "PFAM" ]

[ "PF23035" ]

[ "zf-CCCH_UNK-like_4th" ]

[ 3312 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-983168", "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-DME-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

3

[ "5elk" ]

1

[ "PUB00091175", "PUB00135313" ]

[ "26641712", "25737280" ]

[ "Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt.", "Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt." ]

[ 2016, 2015 ]

2

[]

0

null

[ "Metazoa" ]

[ 3312 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 5, 4, 4, 4 ]

6

true

Domain

Unkempt, zinc finger domain 4

UNK_Znf_4

7

IPR057297

57,297

RNA-dependent RNA polymerase 6-like, second domain

RDR6-like_2nd

Domain

705

false

This entry represents the second domain of RNA-dependent RNA polymerase 6 (RDR6) from Arabidopsis and related plant sequences. This domain has similarity to PH domains and it is predicted to adopt similar β-barrel structure. RDR6 is involved in post-transcriptional gene silencing (PTGS) and natural virus resistance. It...

[]

0

[ "PFAM" ]

[ "PF24577" ]

[ "RDR6_2nd" ]

[ 705 ]

1

[]

0

[]

0

[ "PUB00155822", "PUB00155823", "PUB00155824" ]

[ "36993852", "38138994", "17804793" ]

[ "Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis.", "Quantitative Investigation of FAD2 Cosuppression Reveals RDR6-Dependent and RDR6-Independent Gene Silencing Pathways.", "The small interfering RNA production pathway is required for shoot meristem initi...

[ 2023, 2023, 2007 ]

3

[]

0

null

[ "Streptophyta" ]

[ 705 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 2, 16 ]

3

true

Domain

RNA-dependent RNA polymerase 6-like, second domain

RDR6-like_2nd

3

IPR057298

57,298

RNA-dependent RNA polymerase 6-like, RNA-binding domain

RDR6-like_RBD

Domain

670

false

This entry represents the RNA-binding domain (RBD) found at the N-terminal of RNA-dependent RNA polymerase 6 (RPR6) from Arabidopsis and related sequences from plants. RDR6 is involved in post-transcriptional gene silencing (PTGS) and natural virus resistance. It possesses ssRNA and ssDNA-dependent polymerase activity....

[]

0

[ "PFAM" ]

[ "PF24572" ]

[ "RBD_RDR6" ]

[ 670 ]

1

[]

0

[]

0

[ "PUB00155822", "PUB00155823", "PUB00155824" ]

[ "36993852", "38138994", "17804793" ]

[ "Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis.", "Quantitative Investigation of FAD2 Cosuppression Reveals RDR6-Dependent and RDR6-Independent Gene Silencing Pathways.", "The small interfering RNA production pathway is required for shoot meristem initi...

[ 2023, 2023, 2007 ]

3

[]

0

null

[ "Embryophyta" ]

[ 670 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 2, 14 ]

3

true

Domain

RNA-dependent RNA polymerase 6-like, RNA-binding domain

RDR6-like_RBD

9

IPR057299

57,299

RNF34/RFFL, SAP domain

RNF34_RFFL_SAP

Domain

3,166

false

This entry represents the SAP domains found in RNF34, RFFL and similar animal proteins. RNF34 and RFFL are of E3 ubiquitin-protein ligases that play a crucial role in various biological processes by mediating the ubiquitin-mediated proteasomal degradation of target proteins. They are involved in the regulation of apopt...

[]

0

[ "PFAM" ]

[ "PF23632" ]

[ "SAP_RNF34_RFFL" ]

[ 3166 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-BTA-6804757", "R-BTA-983168", "R-HSA-6804757", "R-HSA-983168", "R-MMU-6804757", "R-MMU-983168", "R-RNO-6804757", "R-RNO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-BTA-6804757", "REACTOME:R-BTA-983168", "REACTOME:R-HSA-6804757", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-6804757", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-6804757", "REACTOME:R-RNO-983168" ]

10

[ "1y02" ]

1

[ "PUB00133983", "PUB00133985", "PUB00133991", "PUB00135934", "PUB00135935", "PUB00154873" ]

[ "15069192", "22064484", "18382127", "18450452", "17121812", "25012219" ]

[ "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.", "RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism.", "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing M...

[ 2004, 2012, 2008, 2008, 2007, 2014 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3166 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 2, 5, 7, 13 ]

5

true

Domain

RNF34/RFFL, SAP domain

RNF34_RFFL_SAP

2

IPR057300

57,300

Rrp5, OB-fold domain

OB_Rrp5

Domain

919

false

This domain is found in the rRNA biogenesis protein Rrp5 from Arabidopsis thaliana and related plant proteins. This domain has a detectable similarity to OB fold domains, in particular to OB domain of 30S ribosomal protein S1 and it is predicted to adopt similar structure. Rrp5 is involved in the biogenesis of rRNA. It...

[]

0

[ "PFAM" ]

[ "PF24682" ]

[ "OB_RRP5" ]

[ 919 ]

1

[]

0

[]

0

[ "PUB00098267", "PUB00098268", "PUB00098269" ]

[ "8896463", "17654514", "23382868" ]

[ "RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.", "Evidence for involvement of NFBP in processing of ribosomal RNA.", "40S ribosome biogenesis co-factors are essential for gametophyte and embryo development." ]

[ 1996, 2008, 2013 ]

3

[]

0

null

[ "Eukaryota" ]

[ 919 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 2, 27 ]

3

true

Domain

Rrp5, OB-fold domain

OB_Rrp5

3

IPR057301

57,301

Rrp5, OB-fold domain 4

Rrp5_OB_4th

Domain

2,114

false

This domain is the 4th OB-fold domain found in the rRNA biogenesis protein Rrp5 from Arabidopsis thaliana and related proteins. It has a detectable similarity to OB fold domains, in particular to OB domain of 30S ribosomal protein S1 and it is predicted to adopt similar structure. Rrp5 is involved in the biogenesis of ...

[]

0

[ "PFAM" ]

[ "PF24685" ]

[ "OB_RRP5_4th" ]

[ 2114 ]

1

[]

0

[ "6rxy", "6rxz" ]

2

[ "PUB00098267", "PUB00098268", "PUB00098269" ]

[ "8896463", "17654514", "23382868" ]

[ "RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.", "Evidence for involvement of NFBP in processing of ribosomal RNA.", "40S ribosome biogenesis co-factors are essential for gametophyte and embryo development." ]

[ 1996, 2008, 2013 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2114 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 2, 23 ]

4

true

Domain

Rrp5, OB-fold domain 4

Rrp5_OB_4th

2

IPR057302

57,302

Rrp5, S1 domain

Rrp5_S1

Domain

3,951

false

This entry represents several divergent S1 domains found in Rrp5 proteins. Rrp5 is involved in the biogenesis of rRNA. It is required for formation of both 18S and 5.8S rRNA in budding yeasts [ ]. In humans, it is also known as NFBP, which is essential for the generation of 18S rRNA [ ]. In Arabidopsis, it is essential...

[]

0

[ "PFAM" ]

[ "PF23459" ]

[ "S1_RRP5" ]

[ 3951 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SPO-6791226" ]

4

[ "6rxy", "6rxz" ]

2

[ "PUB00098267", "PUB00098268", "PUB00098269" ]

[ "8896463", "17654514", "23382868" ]

[ "RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.", "Evidence for involvement of NFBP in processing of ribosomal RNA.", "40S ribosome biogenesis co-factors are essential for gametophyte and embryo development." ]

[ 1996, 2008, 2013 ]

3

[]

0

null

[ "Bacteria", "Candidatus Nanoclepta minutus", "Eukaryota" ]

[ 75, 1, 3875 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 5, 4, 1, 1, 5, 3, 1, 28 ]

9

true

Domain

Rrp5, S1 domain

Rrp5_S1

1

IPR057303

57,303

Rod, N-terminal

Rod_N

Domain

86

false

This entry represents the predicted β-propeller domain found at the N-terminal of Rod ( ) from Drosophila and related sequences from arthropods. Rod, the orthologue of human KNTC1, is the major subunit of the Rod-Zw10-Zwilch (RZZ) complex. RZZ is an essential component of the outer kinetochore during mitosis and helps ...

[]

0

[ "PFAM" ]

[ "PF24504" ]

[ "Rod_N" ]

[ 86 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Neoptera" ]

[ 86 ]

1

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Domain

Rod, N-terminal

Rod_N

3

IPR057305

57,305

PDIA6-like, C-terminal thioredoxin-like domain

Thioredox_PDIA6_C

Domain

3,545

false

This entry represents the C-terminal thioredoxin domain found in human Protein disulfide-isomerase A6 (PDIA6) and similar eukaryotic proteins such as PDI 2-2 and 2-3 in arabidopsis and PDI 2-3 in rice. Protein disulfide-isomerase (PDI) is an enzyme primarily located in the endoplasmic reticulum of eukaryotes and the pe...

[]

0

[ "PFAM" ]

[ "PF24541" ]

[ "Thioredox_PDIA6_C" ]

[ 3545 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.4.1", "R-CEL-381426", "R-CEL-8957275", "R-DME-381426", "R-DME-8957275", "R-HSA-381038", "R-HSA-381426", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275", "R-RNO-381426", "R-RNO-8957275" ]

[ "EC:5.3.4.1", "REACTOME:R-CEL-381426", "REACTOME:R-CEL-8957275", "REACTOME:R-DME-381426", "REACTOME:R-DME-8957275", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

12

[ "8cpq" ]

1

[ "PUB00080416", "PUB00116126", "PUB00116129", "PUB00160300", "PUB00160301" ]

[ "15158710", "12204115", "15466936", "11825568", "16193070" ]

[ "Protein disulfide isomerase.", "Functional analysis of human P5, a protein disulfide isomerase homologue.", "A role for the thiol isomerase protein ERP5 in platelet function.", "Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.", "Tapasin and ERp57 form a stable disulfide-link...

[ 2004, 2002, 2005, 2002, 2005 ]

5

[]

0

null

[ "Eukaryota" ]

[ 3545 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 1, 1, 2, 4, 1, 1, 6, 9 ]

10

true

Domain

PDIA6-like, C-terminal thioredoxin-like domain

Thioredox_PDIA6_C

7

IPR057306

57,306

PelB, C-terminal domain

B-barrel_PelB_C

Domain

618

false

This transmembrane β-barrel domain is found at the C-terminal end of PelB from Pseudomonas aeruginosa and similar proteins from proteobacteria. PelB plays a key role in biofilm formation in this organism [ ].

[]

0

[ "PFAM" ]

[ "PF24604" ]

[ "B-barrel_PelB_C" ]

[ 618 ]

1

[]

0

[ "9h80" ]

1

[ "PUB00155506" ]

[ "28972168" ]

[ "PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 600, 18 ]

2

[]

0

true

Domain

PelB, C-terminal domain

B-barrel_PelB_C

1

IPR057307

57,307

PEP5/VPS11 N-terminal

PEP5_VPS11_N

Domain

3,975

false

This entry represents the β-propeller domain found at the N-terminal of the Pep5-like zinc finger protein from Schizosaccharomyces pombe and its orthologues from human and mice known as vacuolar protein sorting protein 11. Vacuolar protein sorting protein 11 (vps11) aggregates with other Vps proteins to form the homoty...

[]

0

[ "PFAM" ]

[ "PF23341" ]

[ "PEP5_VPS11_N" ]

[ 3975 ]

1

[ "REACTOME" ]

[ "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9754560" ]

1

[ "7zu0", "8cuk", "8qx8" ]

3

[ "PUB00005491", "PUB00015237", "PUB00073489", "PUB00094364", "PUB00155784" ]

[ "10322433", "11814058", "22570702", "30069656", "33452836" ]

[ "The WD repeat: a common architecture for diverse functions.", "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.", "Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.", "WD40 Repeat Proteins...

[ 1999, 2001, 2012, 2018, 2021 ]

5

[]

0

null

[ "Eukaryota" ]

[ 3975 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 2, 1, 4, 5, 1, 4, 1, 2 ]

9

true

Domain

PEP5/VPS11 N-terminal

PEP5_VPS11_N

7

IPR057309

57,309

Peptidoglycan hydrolase PcsB, coiled-coil domain

PcsB_CC

Domain

8,177

false

This coiled-coil (CC) domain is found at the N-terminal of Peptidoglycan hydrolase PcsB from Streptococcus pneumoniae and similar bacterial proteins. PcsB forms a dimer, and the CC domain acts as a pair of molecular tweezers, locking the catalytic domain of each dimeric partner in an inactive configuration [ ]. PcsB is...

[]

0

[ "PFAM" ]

[ "PF24568" ]

[ "CC_PcsB" ]

[ 8177 ]

1

[]

0

[ "4cgk" ]

1

[ "PUB00153385", "PUB00153386", "PUB00153387", "PUB00153388" ]

[ "14651645", "15306019", "19270090", "24804636" ]

[ "Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.", "Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.", "Influen...

[ 2003, 2004, 2009, 2014 ]

4

[]

0

null

[ "Bacteria", "Metazoa", "metagenomes" ]

[ 8118, 3, 56 ]

3

[]

0

true

Domain

Peptidoglycan hydrolase PcsB, coiled-coil domain

PcsB_CC

7

IPR057310

57,310

Period circadian protein homolog PER 1-3, bHLH-like domain

PER1-3_bHLH

Domain

3,859

false

This domain is found in the family of Period circadian protein homologs (PER1, PER2, PER3) found in vertebrates, such as PER2 in human and PER2 in mouse. This domain is a bHLH domain which is known to interact with DNA. It is more closely related to Circadian locomoter output cycles protein kaput (Clock). PER proteins ...

[]

0

[ "PFAM" ]

[ "PF23170" ]

[ "bHLH_PER" ]

[ 3859 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9931510", "R-HSA-9931521", "R-HSA-9931530", "R-HSA-9932298", "R-MMU-9932298", "R-RNO-9932298" ]

[ "REACTOME:R-HSA-9931510", "REACTOME:R-HSA-9931521", "REACTOME:R-HSA-9931530", "REACTOME:R-HSA-9932298", "REACTOME:R-MMU-9932298", "REACTOME:R-RNO-9932298" ]

6

[]

0

[ "PUB00061105", "PUB00107296" ]

[ "22653727", "24005054" ]

[ "Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.", "A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock." ]

[ 2012, 2014 ]

2

[]

0

null

[ "Chordata" ]

[ 3859 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 16, 19, 17 ]

4

true

Domain

Period circadian protein homolog PER 1-3, bHLH-like domain

PER1-3_bHLH

9

IPR057313

57,313

Fatty acyl-CoA reductase Maqu_2507-like

Maqu_2507-like

Family

1,496

false

This protein family includes the fatty acyl-CoA reductase Maqu_2507 from Marinobacter aquaeolei ( ) and similar bacterial sequences. Maqu_2507 catalyses the reduction of fatty acyl-CoA ranging from C8:0 to C20:4 by four electrons to the corresponding fatty alcohols [ ].

[]

0

[ "NCBIFAM" ]

[ "NF005539" ]

[ "PRK07201.1" ]

[ 1496 ]

1

[]

0

[]

0

[ "PUB00160308" ]

[ "22035211" ]

[ "Characterization of a fatty acyl-CoA reductase from Marinobacter aquaeolei VT8: a bacterial enzyme catalyzing the reduction of fatty acyl-CoA to fatty alcohol." ]

[ 2011 ]

1

[ "IPR002347" ]

[]

1

0

1

[ "Bacteria", "Sar", "metagenomes" ]

[ 1482, 3, 11 ]

3

[]

0

true

Family

Fatty acyl-CoA reductase Maqu_2507-like

Maqu_2507-like

1

IPR057314

57,314

PUB2-4-like, N-terminal domain

PUB2-4-like_N

Domain

1,702

false

This domain is found at the N-terminal end of U-box domain-containing protein 2, 3 and 4 from Arabidopsis thaliana (PUB2/3/4) and similar plant sequences. This domain is predicted to show an all-α configuration. It is often found associated with and .

[]

0

[ "PFAM" ]

[ "PF25240" ]

[ "PUB2_N" ]

[ 1702 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[]

0

[]

0

null

[ "Tracheophyta" ]

[ 1702 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 7, 12 ]

3

true

Domain

PUB2-4-like, N-terminal domain

PUB2-4-like_N

7

IPR057315

57,315

PGAP2IP, C-terminal nuclease-like domain

Exo_endo_phos_PGAP2IP_C

Domain

2,662

false

This domain is found C-terminal in the human PGAP2-interacting protein and its homologues in yeast, including . PGAP2IP is composed of three domains. Two of these domains are predicted to adopt a very similar structure consisting of six transmembrane helices, suggesting a possible duplication event in these proteins ( ...

[]

0

[ "PFAM" ]

[ "PF23226" ]

[ "Exo_endo_phos_PGAP2IP" ]

[ 2662 ]

1

[]

0

[]

0

[ "PUB00063839" ]

[ "17761529" ]

[ "Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2, 15, 2638, 7 ]

4

[ "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1, 1, 4, 1, 1 ]

6

true

Domain

PGAP2IP, C-terminal nuclease-like domain

Exo_endo_phos_PGAP2IP_C

5

IPR057316

57,316

Rab11-FIP3/4 domain

Rab11-FIP3/4_dom

Domain

3,833

false

This domain is found in human Rab11 family-interacting protein 3 and 4 (Rab11-FIP3/4) and similar proteins mainly found in animals. Proteins in this family are involved in regulating endocytic trafficking, cytokinesis, and intracellular ciliogenesis by facilitating membrane delivery [ , , ]. This domain is predicted to...

[]

0

[ "PFAM" ]

[ "PF25450" ]

[ "Rab11-FIP3" ]

[ 3833 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-5620916", "R-HSA-5620916", "R-MMU-5620916" ]

[ "REACTOME:R-DRE-5620916", "REACTOME:R-HSA-5620916", "REACTOME:R-MMU-5620916" ]

3

[]

0

[ "PUB00077776", "PUB00147713", "PUB00160467" ]

[ "16148947", "25035494", "12470645" ]

[ "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.", "Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.", "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in He...

[ 2005, 2014, 2002 ]

3

[]

0

null

[ "Bacillati", "Opisthokonta", "Pyrodictium abyssi" ]

[ 2, 3830, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 9, 13, 4, 2, 9 ]

6

true

Domain

Rab11-FIP3/4 domain

Rab11-FIP3/4_dom

9

IPR057317

57,317

PH-like domain, trypanosoma

PH-like_tryp

Domain

35

false

This domain is found in uncharacterised proteins mainly from Trypanosomes. It has a weak sequence similarity to known PH-domains and it is predicted to adopt similar structure. It contains a conserved GTFKT sequence motif. This domain is also found in putative Glucosyltransferases, Rab-like GTPase activators and Myotub...

[]

0

[ "PFAM" ]

[ "PF23732" ]

[ "PH_22" ]

[ 35 ]

1

[]

0

[]

0

[ "PUB00160311" ]

[ "33604931" ]

[ "Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b." ]

[ 2021 ]

1

[]

0

null

[ "Metakinetoplastina" ]

[ 35 ]

1

[]

0

true

Domain

PH-like domain, trypanosoma

PH-like_tryp

4

IPR057318

57,318

Renin receptor, N-terminal domain

RENR_N

Domain

2,111

false

This domain is found N-terminal in the human renin receptor and related proteins, including the Drosophila homologue, known as dPRR. The domain represented by this entry is predicted to adopt an α/β structure with topological similarity to alkaline phosphatase. Renin receptor is a multifunctional protein which function...

[]

0

[ "PFAM" ]

[ "PF25294" ]

[ "RENR_N" ]

[ 2111 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2022377", "R-BTA-6798695", "R-DME-2022377", "R-DME-6798695", "R-HSA-2022377", "R-HSA-6798695", "R-MMU-2022377", "R-MMU-6798695", "R-RNO-2022377", "R-RNO-6798695" ]

[ "REACTOME:R-BTA-2022377", "REACTOME:R-BTA-6798695", "REACTOME:R-DME-2022377", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-2022377", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-2022377", "REACTOME:R-RNO-6798695" ]

10

[ "6vq6", "6vq7", "6vq8", "6vqc", "6vqg", "6vqh", "6wlw", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7khr", "7u4t", "7u8o", "7u8p", "7u8q", "7u8r", "7unf", "7uzf", "7uzg", "7uzh", "7uzi", "9b8o", "9bra", "9brb", "9brc", "9brd", "9brq", "9brr", "9brs", "9brt"...

38

[ "PUB00016428", "PUB00093608", "PUB00095097", "PUB00159963", "PUB00159964", "PUB00159965", "PUB00159966", "PUB00159968" ]

[ "12045255", "29995586", "30374053", "26376863", "29127204", "30985297", "32276428", "20579883" ]

[ "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.", "ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum.", "TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling.", "Conditional depl...

[ 2002, 2018, 2018, 2015, 2017, 2019, 2020, 2010 ]

8

[]

0

null

[ "Eukaryota" ]

[ 2111 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 22, 2, 7 ]

5

true

Domain

Renin receptor, N-terminal domain

RENR_N

1

IPR057320

57,320

RESC1/2, CYTH-like domain

RESC1_2_CYTH-like_dom

Domain

97

false

This domain is found in the RNA-editing substrate-binding complex protein 1 and 2 (RESC1, , and RESC2, ) from Trypanosoma brucei and related proteins. In Trypanosoma, the editosome, composed of RNA-editing substrate-binding complex (RESC) and RNA-editing catalytic complex (RECC) is involved in guide RNA (gRNA)-programm...

[]

0

[ "PFAM" ]

[ "PF25477" ]

[ "RESC1_2" ]

[ 97 ]

1

[]

0

[ "8cdp", "8fn4", "8fn6" ]

3

[ "PUB00160174", "PUB00160175" ]

[ "37410820", "36999600" ]

[ "Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.", "Structural basis for guide RNA selection by the RESC1-RESC2 complex." ]

[ 2023, 2023 ]

2

[]

0

null

[ "Metakinetoplastina" ]

[ 97 ]

1

[]

0

true

Domain

RESC1/2, CYTH-like domain

RESC1_2_CYTH-like_dom

2

IPR057321

57,321

RFX1-4/6/8-like, BCD domain

RFX1-4/6/8-like_BCD

Domain

10,430

false

This domain is found in site specific DNA binding proteins that are members of the RFX family of transcription factors, including human RFX (1-4/6/8) [ ]. Members of this family are found in animals and fungi, and initially were identified as regulatory factors that bind to a conserved cis-regulatory element called the...

[]

0

[ "PFAM" ]

[ "PF25340" ]

[ "BCD_RFX" ]

[ 10430 ]

1

[ "REACTOME" ]

[ "R-HSA-210745" ]

[ "REACTOME:R-HSA-210745" ]

1

[]

0

[ "PUB00090092" ]

[ "18673564" ]

[ "Identification and characterization of novel human tissue-specific RFX transcription factors." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota", "Neoroseomonas marina" ]

[ 10429, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 30, 9, 16, 14, 1, 27, 1, 1 ]

9

true

Domain

RFX1-4/6/8-like, BCD domain

RFX1-4/6/8-like_BCD

6

IPR057322

57,322

Rgr-1, C-terminal domain

Rgr-1_C

Domain

59

false

This domain is found at the C-terminal end of Mediator of RNA polymerase II transcription subunit 14 from Caenorhabditis elegans (Rgr-1) and similar nematode proteins. Rgr-1 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Thi...

[]

0

[ "PFAM" ]

[ "PF25308" ]

[ "Rgr-1_C" ]

[ 59 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 59 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Rgr-1, C-terminal domain

Rgr-1_C

6

IPR057323

57,323

RHG40/28/18, C-terminal ubiquitin-like domain

RHG40/28/18_ubiquitin

Domain

3,435

false

This domain is found at the C-terminal end of human Rho GTPase-activating protein 40, 28 and 18 (RHG40/28/18) and similar GTPase activators for Rho-type GTPases. This activity plays a crucial role in regulating cellular processes such as actin polymerisation, cell shape, spreading, and migration [ , ]. This domain is p...

[]

0

[ "PFAM" ]

[ "PF25442" ]

[ "Ubiquitin_RHG40_C" ]

[ 3435 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8980692", "R-HSA-9013106", "R-HSA-9013148", "R-MMU-8980692", "R-MMU-9013106", "R-MMU-9013148" ]

[ "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013148", "REACTOME:R-MMU-8980692", "REACTOME:R-MMU-9013106", "REACTOME:R-MMU-9013148" ]

6

[]

0

[ "PUB00160465", "PUB00160466" ]

[ "21865595", "25778702" ]

[ "ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.", "YAP is essential for tissue tension to ensure vertebrate 3D body shape." ]

[ 2011, 2015 ]

2

[]

0

null

[ "Metazoa" ]

[ 3435 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 10, 7, 8 ]

4

true

Domain

RHG40/28/18, C-terminal ubiquitin-like domain

RHG40/28/18_ubiquitin

9

IPR057324

57,324

Ribonuclease II, winged helix domain

WH_RNase_II

Domain

1,166

false

This entry represents a winged helix domain found in ribonuclease II (RNR1) from Arabidopsis thaliana and similar sequences from plants, cyanobacteria and some proteobacterial species. RNR1 is a 3'-5' exoribonuclease that catalyses 3' maturation of chloroplast and mitochondrion ribosomal RNAs. It degrades short nucleot...

[]

0

[ "PFAM" ]

[ "PF25255" ]

[ "WHD_RNase_II" ]

[ 1166 ]

1

[]

0

[]

0

[ "PUB00158851", "PUB00158852" ]

[ "15891117", "23061883" ]

[ "RNR1, a 3'-5' exoribonuclease belonging to the RNR superfamily, catalyzes 3' maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana.", "Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation." ]

[ 2005, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 397, 766, 3 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 9 ]

3

true

Domain

Ribonuclease II, winged helix domain

WH_RNase_II

5

IPR057326

57,326

Ketoreductase domain

KR_dom

Domain

341,234

false

The ketoreductase (KR) domain is a conserved catalytic domain that belongs to the short-chain dehydrogenase/reductase (SDR) superfamily and contains a Rossmann fold, which is crucial for binding the NADPH cofactor [ ]. Its primary function is to catalyse the NADPH-dependent reduction of beta-keto groups to beta-hydroxy...

[]

0

[ "SMART" ]

[ "SM00822" ]

[ "PKS_KR" ]

[ 341234 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-70895", "R-BTA-75105", "R-BTA-9837999", "R-CFA-75105", "R-DDI-199220", "R-DDI-75105", "R-DME-1251985", "R-DME-193368", "R-DME-2046106", "R-DME-389887", "R-DME-390247", "R-DME-70895", "R-DME-75896", "R-DME-8866904", "R-DME-8866907", "R-DME-9033241", "R-DME-9837999", "R-DRE-75...

[ "REACTOME:R-BTA-70895", "REACTOME:R-BTA-75105", "REACTOME:R-BTA-9837999", "REACTOME:R-CFA-75105", "REACTOME:R-DDI-199220", "REACTOME:R-DDI-75105", "REACTOME:R-DME-1251985", "REACTOME:R-DME-193368", "REACTOME:R-DME-2046106", "REACTOME:R-DME-389887", "REACTOME:R-DME-390247", "REACTOME:R-DME-7089...

50

[ "1edo", "1geg", "1gz6", "1h5q", "1hdc", "1i01", "1iy8", "1ja9", "1k2w", "1q7b", "1q7c", "1uay", "1uls", "1uzl", "1uzm", "1uzn", "1vl8", "1x1e", "1zbq", "1zem", "2a4k", "2bd0", "2c07", "2cdh", "2cf2", "2ekp", "2ekq", "2et6", "2fr0", "2fr1", "2fwm", "2hq1"...

377

[ "PUB00040785", "PUB00160324", "PUB00160325", "PUB00160326" ]

[ "16564177", "26863427", "27118242", "18723688" ]

[ "The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.", "Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.", "Recognition of acyl carrier proteins...

[ 2006, 2016, 2016, 2008 ]

4

[]

[ "IPR013968" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2429, 280330, 56156, 2, 2317 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 43, 7, 23, 31, 6, 20, 17, 17, 65, 21, 1, 63 ]

12

true

Domain

Ketoreductase domain

KR_dom

2

IPR057327

57,327

RNA-binding protein vts1-like, alpha-helical domain

Vts1_dom

Domain

4,294

false

This domain is found in RNA-binding protein vts1 from Aspergillus fumigatus and related proteins from animals and fungi, including zinc finger CCHC domain-containing protein 2 (ZCCHC2), protein Smaug homolog 1 (SMAG1) from vertebrates and germline survival defective-1 from C. elegans. Vts1 is involved in post-transcrip...

[]

0

[ "PFAM" ]

[ "PF25479" ]

[ "Vts1" ]

[ 4294 ]

1

[]

0

[ "8oik" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4294 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 5, 1, 8, 4, 1, 12 ]

7

true

Domain

RNA-binding protein vts1-like, alpha-helical domain

Vts1_dom

4

IPR057328

57,328

RNase T2-like, C-terminal domain

RNaseT2L_C

Domain

1,260

false

This domain is found C-terminal in Ribonuclease T2-like from Emericella nidulans and related fungal proteins. Ribonuclease T2-like enzymes preferentially cleave single-stranded RNA between purine and uridine residues to generate two nucleotide fragments with 2'3'-cyclic phosphate adenosine/guanosine terminus and uridin...

[]

0

[ "PFAM" ]

[ "PF25488" ]

[ "RNaseT2L_C" ]

[ 1260 ]

1

[ "EC", "REACTOME" ]

[ "4.6.1.19", "R-SCE-6798695" ]

[ "EC:4.6.1.19", "REACTOME:R-SCE-6798695" ]

2

[]

0

[ "PUB00160179", "PUB00160180" ]

[ "20189811", "32903619" ]

[ "T2 Family ribonucleases: ancient enzymes with diverse roles.", "RNase T2 in Inflammation and Cancer: Immunological and Biological Views." ]

[ 2010, 2020 ]

2

[]

0

null

[ "Dikarya" ]

[ 1260 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

RNase T2-like, C-terminal domain

RNaseT2L_C

2

IPR057329

57,329

Rol-3, five-bladed beta-propeller

Beta-prop_Rol-3

Domain

218

false

This domain is found in the Protein roller-3 (Rol-3) from Caenorhabditis elegans and related proteins. Rol-3 plays a crucial role in the development and locomotion in nematodes. Rol-3 has an essential function during early to mid-larval development [ ]. The domain represented by this entry is predicted to fold into a f...

[]

0

[ "PFAM" ]

[ "PF25494" ]

[ "Beta-prop_Rol-3" ]

[ 218 ]

1

[ "REACTOME" ]

[ "R-CEL-8863795" ]

[ "REACTOME:R-CEL-8863795" ]

1

[]

0

[ "PUB00160112" ]

[ "8138151" ]

[ "The generation and genetic analysis of suppressors of lethal mutations in the Caenorhabditis elegans rol-3(V) gene." ]

[ 1994 ]

1

[]

0

null

[ "Eukaryota" ]

[ 218 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Rol-3, five-bladed beta-propeller

Beta-prop_Rol-3

3

IPR057330

57,330

Rv3818-like, SCP2-like domain

SCP2_Rv3818

Domain

1,203

false

This domain is found in the putative Rieske 2Fe-2S iron-sulfur protein Rv3818 from Mycobacterium tuberculosis and similar actinobacterial proteins. Rv3818 was identified as a high-confidence drug target. This domain is predicted to adopt an α-β configuration and is usually found associated with and .

[]

0

[ "PFAM" ]

[ "PF25451" ]

[ "SCP2_Rv3818" ]

[ 1203 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 1167, 36 ]

2

[]

0

true

Domain

Rv3818-like, SCP2-like domain

SCP2_Rv3818

5

IPR057331

57,331

Salactin

Family

199

false

This protein family represents salactin ( ) from Halobacterium salinarum and similar sequences. Salactin is an actin homologue found in halophilic archaea [ ], which is involved in DNA segregation [ ].

[]

0

[ "PFAM" ]

[ "PF25229" ]

[ "Salactin" ]

[ 199 ]

1

[]

0

[]

0

[ "PUB00160183" ]

[ "37966230" ]

[ "Salactin, a dynamically unstable actin homolog in Haloarchaea." ]

[ 2023 ]

1

[]

0

null

[ "Methanobacteriota", "Sphingobacterium athyrii" ]

[ 198, 1 ]

2

[]

0

true

Family

Salactin

3

IPR057332

57,332

SBNO, alpha/beta domain

SBNO_a/b_dom

Domain

4,985

false

This domain is found in the family of Strawberry notch homologue (SBNO 1/2) proteins from animals and includes the plant homologue Protein FORGETTER 1. SBNO2 acts as a transcriptional coregulator exhibiting both coactivator and corepressor functions [ ]. It inhibits the DCSTAMP-repressive activity of TAL1 and enhances ...

[]

0

[ "PFAM" ]

[ "PF25373" ]

[ "SBNO" ]

[ 4985 ]

1

[]

0

[]

0

[ "PUB00072728", "PUB00083119", "PUB00160184" ]

[ "18025162", "27680998", "23980096" ]

[ "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.", "Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling.", "Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression...

[ 2007, 2016, 2013 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4985 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 9, 3, 5, 8, 8, 10, 12 ]

9

true

Domain

SBNO, alpha/beta domain

SBNO_a/b_dom

3

IPR057333

57,333

Adhesion GPCR Gpr126, SEA domain

SEA_Gpr126

Domain

1,545

false

This entry represents the Sperm protein, Enterokinase and Agrin (SEA) domain found in the adhesion G protein-coupled receptor Gpr126/ADGRG6 from vertebrates. The domain adopts a ferredoxin-like α/β sandwich fold [ ] and is located between the PTX and HormR domains in the extracellular region. In human GPR126, this doma...

[]

0

[ "PFAM" ]

[ "PF25307" ]

[ "SEA_Gpr126" ]

[ 1545 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9619665", "R-HSA-9619665", "R-MMU-9619665" ]

[ "REACTOME:R-DRE-9619665", "REACTOME:R-HSA-9619665", "REACTOME:R-MMU-9619665" ]

3

[ "6v55" ]

1

[ "PUB00137745", "PUB00160185", "PUB00160457", "PUB00160458", "PUB00160459", "PUB00160460", "PUB00160461", "PUB00160462", "PUB00160463" ]

[ "25217645", "31924782", "15189448", "25695270", "25954032", "27501152", "32219165", "34767447", "39087467" ]

[ "GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.", "Structural basis for adhesion G protein-coupled receptor Gpr126 function.", "DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites....

[ 2014, 2020, 2004, 2015, 2015, 2016, 2020, 2021, 2024 ]

9

[]

0

null

[ "Gnathostomata" ]

[ 1545 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 48, 2, 3, 5 ]

4

true

Domain

Adhesion GPCR Gpr126, SEA domain

SEA_Gpr126

7

IPR057334

57,334

LRR-containing protein, second PH domain

PH_2nd_LRR

Domain

1,105

false

This entry represents the second of two N-terminal pleckstrin homology (PH) domains found in fungal proteins that also contain C-terminal leucine-rich repeats (LRRs).

[]

0

[ "PFAM" ]

[ "PF25353" ]

[ "PH_2nd_LRR" ]

[ 1105 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1105 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

LRR-containing protein, second PH domain

PH_2nd_LRR

8

IPR057335

57,335

Selenocysteine-specific elongation factor, beta-barrel domain

Beta-barrel_SelB

Domain

6,206

false

This domain is found in Selenocysteine-specific elongation factor from Escherichia coli (SelB) and similar bacterial proteins. SelB is a translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon.

[]

0

[ "PFAM" ]

[ "PF25461" ]

[ "Beta-barrel_SelB" ]

[ 6206 ]

1

[]

0

[ "5lzb", "5lzc", "5lzd" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6057, 18, 131 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Selenocysteine-specific elongation factor, beta-barrel domain

Beta-barrel_SelB

1

IPR057336

57,336

Spore germination protein, N-terminal domain

GerAC_N

Domain

12,953

false

This entry represents the N-terminal domain of spore germination proteins such as GERXC, GERLC, GERKC, GERAC, GERBC and others. In Bacillus cereus, GERLC contributes to the L-alanine germination response [ ].

[]

0

[ "PFAM" ]

[ "PF25198" ]

[ "Spore_GerAC_N" ]

[ 12953 ]

1

[]

0

[ "3n54" ]

1

[ "PUB00061591", "PUB00160327" ]

[ "20654628", "12101297" ]

[ "Crystal structure of the GerBC component of a Bacillus subtilis spore germinant receptor.", "Germination of Bacillus cereus spores in response to L-alanine and to inosine: the roles of gerL and gerQ operons." ]

[ 2010, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 12918, 6, 29 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Spore germination protein, N-terminal domain

GerAC_N

6

IPR057338

57,338

Smf/DprA, SAM domain

DprA_SAM

Domain

2,069

false

This entry represents the N-terminal domain found in Smf and DprA proteins mainly from Enterobacterales. Smf (Smf homologue) and DprA (DNA processing chain A) proteins are involved in DNA processing and transformation. The domain adopts a SAM-like fold, similar to other domains involved in nucleic acid interactions. Dp...

[]

0

[ "PFAM" ]

[ "PF25317" ]

[ "SAM_SMF" ]

[ 2069 ]

1

[]

0

[]

0

[ "PUB00009463", "PUB00044733", "PUB00078829" ]

[ "10640603", "17803906", "23440217" ]

[ "The dprA gene is required for natural transformation of Helicobacter pylori.", "A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA.", "Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence."...

[ 2000, 2007, 2013 ]

3

[]

0

null

[ "Bacteria", "Timema douglasi", "metagenomes" ]

[ 2066, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Smf/DprA, SAM domain

DprA_SAM

3

IPR057339

57,339

Target of rapamycin complex 2 subunit MAPKAP1-like, Ras-binding domain

RBD_SIN1

Domain

1,610

false

This entry represents the Ras-binding domain (RBD) found in human Target of rapamycin complex 2 subunit MAPKAP1 (SIN1) and similar proteins mainly found in vertebrates and nematodes. SIN1 is an essential component of mTOR complex 2 (mTORC2), which helps regulate cell survival and proliferation through phosphorylation o...

[]

0

[ "PFAM" ]

[ "PF25322" ]

[ "RBD_SIN1" ]

[ 1610 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1257604", "R-CEL-389357", "R-CEL-5218920", "R-CEL-6804757", "R-CEL-9856530", "R-GGA-1257604", "R-GGA-389357", "R-GGA-5218920", "R-GGA-6804757", "R-GGA-9856530", "R-HSA-1257604", "R-HSA-389357", "R-HSA-5218920", "R-HSA-5674400", "R-HSA-6804757", "R-HSA-9856530", "R-MMU-1257604"...

[ "REACTOME:R-CEL-1257604", "REACTOME:R-CEL-389357", "REACTOME:R-CEL-5218920", "REACTOME:R-CEL-6804757", "REACTOME:R-CEL-9856530", "REACTOME:R-GGA-1257604", "REACTOME:R-GGA-389357", "REACTOME:R-GGA-5218920", "REACTOME:R-GGA-6804757", "REACTOME:R-GGA-9856530", "REACTOME:R-HSA-1257604", "REACTOME:...

26

[ "5zcs", "6zwm", "6zwo", "7lc1", "7lc2", "7pe7", "7pe8", "7pe9", "7tzo", "7vv8", "7vv9", "7vvb", "7vvg" ]

13

[ "PUB00158846", "PUB00160169", "PUB00160170", "PUB00160171", "PUB00160172", "PUB00160173", "PUB00160737", "PUB00160738", "PUB00160739" ]

[ "28264193", "29567957", "33158864", "34380736", "35926713", "35522713", "21806543", "28968999", "30837283" ]

[ "Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.", "Cryo-EM structure of human mTOR complex 2.", "The 3.2-A resolution structure of human mTORC2.", "RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.", "Interactions between mTORC2 ...

[ 2017, 2018, 2020, 2021, 2022, 2022, 2011, 2017, 2019 ]

9

[]

0

null

[ "Opisthokonta" ]

[ 1610 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 2, 2 ]

5

true

Domain

Target of rapamycin complex 2 subunit MAPKAP1-like, Ras-binding domain

RBD_SIN1

4

IPR057340

57,340

Single-strand DNA endonuclease 1, chromo domain

Chromo_SEND1

Domain

556

false

This domain is found in Single-strand DNA endonuclease 1 from Arabidopsis thaliana (SEND1) and similar plant proteins. SEND1 cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA with a specific cleavage site in the 5' overhang strand exactly one nucleotide 3' of the branch point. ...

[]

0

[ "PFAM" ]

[ "PF25386" ]

[ "Chromo_SEND1" ]

[ 556 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Streptophyta" ]

[ 556 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 4 ]

3

true

Domain

Single-strand DNA endonuclease 1, chromo domain

Chromo_SEND1

2

IPR057342

57,342

RapA, DEXH-box helicase domain

DEXDc_RapA

Domain

12,921

false

This entry describes the DEXH-box helicase domain found in prokaryotic RapA proteins. In prokaryotes, RapA's DEXH-box domain functions to remodel protein-nucleic acid complexes, particularly in the context of RNA polymerase recycling during transcription [ ]. RapA, a prokaryotic Swi2/Snf2 ATPase associated with RNA pol...

[]

0

[ "CDD" ]

[ "cd18011" ]

[ "DEXDc_RapA" ]

[ 12921 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "4s20", "6bog", "7m8e", "7mkn", "7mkq", "8so8", "8sp4", "8spg", "8t0l" ]

9

[ "PUB00003826", "PUB00004037", "PUB00005492", "PUB00033620", "PUB00054674", "PUB00055098", "PUB00071645", "PUB00079379", "PUB00086839", "PUB00094062", "PUB00096999", "PUB00099508", "PUB00102121", "PUB00102122", "PUB00113956", "PUB00138636", "PUB00138637", "PUB00138638", "PUB001434...

[ "1552844", "2563148", "10322435", "11545728", "20941364", "11751638", "19234488", "21779027", "15627498", "16935882", "16935875", "19747077", "23416748", "23542735", "20225155", "18508648", "18786849", "16568948", "26272746", "36993374", "39779919", "32050838" ]

[ "D-E-A-D protein family of putative RNA helicases.", "Birth of the D-E-A-D box.", "Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.", "DExD/H box RNA helicases: from generic motors to specific dissociation functions.", "Comparative structural analysis of human DEAD-box RNA ...

[ 1992, 1989, 1999, 2001, 2010, 2001, 2009, 2011, 2005, 2006, 2006, 2009, 2013, 2013, 2010, 2008, 2008, 2006, 2015, 2023, 2025, 2020 ]

22

[ "IPR000330" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 341, 12455, 7, 3, 115 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RapA, DEXH-box helicase domain

DEXDc_RapA

1

IPR057343

57,343

PurR, sensor domain

PurR_sensor_dom

Domain

3,593

false

This entry represents the sensor domain found at the C-terminal in members of the PurR family. Dimerisation sites are present in the C-terminal domain, and binding of corepressors is cooperative [ ]. This domain is also present in ribose operon repressor proteins. The purR gene encodes a transcriptional repressor of th...

[]

0

[ "CDD" ]

[ "cd06275" ]

[ "PBP1_PurR" ]

[ 3593 ]

1

[]

0

[ "1bdh", "1bdi", "1dbq", "1jfs", "1jft", "1jh9", "1jhz", "1pnr", "1qp0", "1qp4", "1qp7", "1qpz", "1qqa", "1qqb", "1vpw", "1wet", "1zay", "2pua", "2pub", "2puc", "2pud", "2pue", "2puf", "2pug", "9ny7", "9ny8" ]

26

[ "PUB00001699", "PUB00002732", "PUB00003610", "PUB00054593", "PUB00054594", "PUB00056198", "PUB00080913", "PUB00080914", "PUB00080916", "PUB00108015", "PUB00108016", "PUB00160347", "PUB00160348" ]

[ "8543068", "1639817", "8336670", "2404765", "1400170", "11741199", "15810013", "15313245", "12598694", "1304370", "11266612", "24966856", "25035932" ]

[ "Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors.", "A family of bacterial regulators homologous to Gal and Lac repressors.", "Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.", "Autoreg...

[ 1995, 1992, 1993, 1990, 1992, 1999, 2005, 2004, 2003, 1992, 2001, 2014, 2014 ]

13

[ "IPR046335" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 3592, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

PurR, sensor domain

PurR_sensor_dom

5

IPR057345

57,345

Transcription initiation factor TFIID subunit 2, Ig-like domain

Ig-like_TAF2

Domain

4,623

false

This entry represents the immunoglobulin-like (Ig-like) domain found in transcription factor TFIID subunit 2 (TAF2) from eukaryotes. This domain is inserted between subdomains 2 and 4 of the aminopeptidase-like region of TAF2 [ , ]. The aminopeptidase-like region of TAF2 is involved in downstream promoter recognition a...

[]

0

[ "PFAM" ]

[ "PF25316" ]

[ "TAF2_3rd" ]

[ 4623 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-674695", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6804756", "R-HSA-73776", "R-HSA-73779", ...

[ "REACTOME:R-CEL-674695", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-DME-76042", "REACTOME:R-HSA-167161", ...

36

[ "5fur", "6hqa", "6mzc", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egh", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq", "8war", "8was" ]

29

[ "PUB00098146", "PUB00101058", "PUB00122513", "PUB00125866", "PUB00160919" ]

[ "30442764", "33795473", "30405110", "9774672", "9418870" ]

[ "Structure of human TFIID and mechanism of TBP loading onto promoter DNA.", "Structural insights into preinitiation complex assembly on core promoters.", "Molecular structure of promoter-bound yeast TFIID.", "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containi...

[ 2018, 2021, 2018, 1998, 1998 ]

5

[]

0

null

[ "Archaea", "Eukaryota", "Flavobacteriales" ]

[ 2, 4615, 6 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 3, 2, 7, 2, 1, 2, 3, 1, 1, 3 ]

12

true

Domain

Transcription initiation factor TFIID subunit 2, Ig-like domain

Ig-like_TAF2

9

IPR057346

57,346

Talin-1/2, VBS2 domain

Talin1/2_VBS2

Domain

4,562

false

This entry represents the Talin VBS2 domain. Talin is an adaptor protein that activates integrin family of cell adhesion molecules and couples them to the actin cytoskeleton. The integrin activation is known to involve binding of the talin FERM domain to membrane proximal sequences in the cytoplasmic domain of the inte...

[]

0

[ "PFAM" ]

[ "PF25177" ]

[ "Talin_VBS2" ]

[ 4562 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-114608", "R-HSA-354192", "R-HSA-354194", "R-HSA-372708", "R-HSA-381038", "R-HSA-399955", "R-HSA-445355", "R-HSA-5674135", "R-HSA-6802946", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-6802955", "R-HSA-9649948", "R-HSA-9656223", "R-HSA-9856530", "R-MMU-114608", "R-MMU-354192", "R...

[ "REACTOME:R-HSA-114608", "REACTOME:R-HSA-354192", "REACTOME:R-HSA-354194", "REACTOME:R-HSA-372708", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-399955", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-5674135", "REACTOME:R-HSA-6802946", "REACTOME:R-HSA-6802948", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA...

22

[ "1u6h", "1u89", "1zvz", "2l7a", "6r9t", "8vdo", "8vdp", "8vdq", "8vdr" ]

9

[ "PUB00031679" ]

[ "15642262" ]

[ "A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head." ]

[ 2005 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 4562 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 4, 2, 11, 11 ]

5

true

Domain

Talin-1/2, VBS2 domain

Talin1/2_VBS2

3

IPR057347

57,347

TANGO6, N-terminal domain

TANGO6_N

Domain

1,302

false

This domain is found in the Transport and Golgi organisation protein 6 homolog (TANGO6) and related proteins. It is predicted to fold into an array of α-helices. TANGO6 associates with COPI vesicles. Cytoplasmic TANGO6 tethers to COPI vesicle via a signal anchor and two transmembrane domains. Its N- and C-terminal cyto...

[]

0

[ "PFAM" ]

[ "PF25267" ]

[ "TANGO6_N" ]

[ 1302 ]

1

[]

0

[]

0

[ "PUB00160190" ]

[ "38490996" ]

[ "TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry." ]

[ 2024 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1302 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 2, 10 ]

4

true

Domain

TANGO6, N-terminal domain

TANGO6_N

4

IPR057348

57,348

TELO2, ARM repeat domain

TELO2_ARM

Domain

2,134

false

This entry represents an ARM repeat domain found in TELO2 proteins that forms part of the TTT (TELO2-TTI1-TTI2) complex. Recent cryo-EM structures show that this domain adopts an elongated α-helical solenoid structure typical of ARM repeats [ , ]. The domain mediates key interactions with TTI1 within the TTT complex, w...

[]

0

[ "PFAM" ]

[ "PF25320" ]

[ "TELO2_ARM" ]

[ 2134 ]

1

[]

0

[ "7f4u", "7ole" ]

2

[ "PUB00088256", "PUB00151832", "PUB00155883" ]

[ "18334620", "34233195", "34838521" ]

[ "Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.", "Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.", "Structure of the Human TELO2-TTI1-TTI2 Complex." ]

[ 2008, 2021, 2022 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2134 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 2, 4, 1, 8, 3, 1, 13 ]

8

true

Domain

TELO2, ARM repeat domain

TELO2_ARM

2