interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR057466 | 57,466 | CFAP46, N-terminal TPR repeat | CFAP46_TPR | Repeat | 980 | false | false | This region of tetratricopeptide (TPR)-like repeats is found at the N-terminal in human Cilia- and flagella-associated protein 46 (CFAP46) and similar eukaryotic proteins. CFAP46 is a part of the central apparatus of the cilium axoneme and plays a role in cilium movement and thereby cell motility [ ]. The tetratrico pe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25439"
] | [
"TPR_CFAP46_N"
] | [
980
] | 1 | [] | [] | [] | 0 | [
"7n6g",
"7sqc",
"9ijj"
] | 3 | [
"PUB00001313",
"PUB00005443",
"PUB00005695",
"PUB00014195",
"PUB00089843"
] | [
"9482716",
"7667876",
"1882418",
"14659697",
"22573824"
] | [
"The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.",
"Tetratrico peptide repeat interactions: to TPR or not to TPR?",
"The TPR snap helix: a novel protein repeat motif from mitosis to transcription.",
"TPR proteins: the versati... | [
1998,
1995,
1991,
2003,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
980
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
7,
2
] | 4 | true | Repeat | CFAP46, N-terminal TPR repeat | CFAP46, N-terminal TPR repeat | CFAP46_TPR | 9 |
IPR057467 | 57,467 | CFAP65, eight Ig-like domain | Ig_CFAP65_8th | Domain | 1,196 | false | false | This entry represents the eight Ig-like domain of CFAP65 and related sequences. Cilia-Flagella-Associated Protein 65 (CFAP65) is involved in the structural and functional integrity of cilia and flagella. This protein is implicated in the process of flagellar formation and is essential for proper sperm motility, suggest... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25248"
] | [
"Ig_CFAP65_8th"
] | [
1196
] | 1 | [] | [] | [] | 0 | [
"9ijj"
] | 1 | [
"PUB00155585",
"PUB00160504"
] | [
"33472045",
"22761584"
] | [
"Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.",
"The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility."
] | [
2021,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1196
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
2,
3
] | 4 | true | Domain | CFAP65, eight Ig-like domain | CFAP65, eight Ig-like domain | Ig_CFAP65_8th | 3 |
IPR057468 | 57,468 | HOIL-1/Sharpin, LUBAC thetering domain | HOIL-1/Sharpin_LTM | Domain | 1,425 | false | false | This entry describes the Linear Ubiquitin Chain Assembly Complex (LUBAC)-tethering domain (LTM) found in the two LUBAC accessory subunits HOIL-1L and SHARPIN in vertebrates. These domains from both proteins heterodimerise and fold into a single globular domain. stabilising the multi-protein E3 ubiquitin ligase LUBAC co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25393"
] | [
"LTM"
] | [
1425
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-HSA-6794361",
"R-HSA-983168",
"R-MMU-5357786",
"R-MMU-5357905",
"R-MMU-5357956",
"R-MMU-983168",
"R-RNO-5357786",
"R-RNO-5357905",
"R-RNO-5357956",
"R-RNO-983168"
] | [
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-5357956",
"REACTOME:R-HSA-6794361",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-5357786",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-5357956",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-5357786",
"REACTOME:R-RNO-5357905",
"REACTOME:... | 13 | [
"5y3t",
"8k6p",
"8k6q"
] | 3 | [
"PUB00060254",
"PUB00160150"
] | [
"22549881",
"29694895"
] | [
"Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold.",
"Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization."
] | [
2012,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1425
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
13,
2,
10
] | 4 | true | Domain | HOIL-1/Sharpin, LUBAC thetering domain | HOIL-1/Sharpin, LUBAC thetering domain | HOIL-1/Sharpin_LTM | 9 |
IPR057469 | 57,469 | MAP kinase-activating death domain protein, C-terminal PH-like domain | PH_MADD | Domain | 5,452 | false | false | This entry represents a C-terminal pleckstrin homology (PH)-like domain found in human MAP kinase-activating death domain (MADD) and similar animal proteins. MADD proteins function as adaptor proteins in cell death and MAP kinase signalling pathways [ , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25328"
] | [
"PH_MADD"
] | [
5452
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8876198",
"R-DME-8876198",
"R-HSA-5357905",
"R-HSA-8876198",
"R-MMU-5357905",
"R-MMU-8876198",
"R-RNO-5357905",
"R-RNO-8876198"
] | [
"REACTOME:R-CEL-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-8876198",
"REACTOME:R-RNO-5357905",
"REACTOME:R-RNO-8876198"
] | 8 | [] | 0 | [
"PUB00090384",
"PUB00159992",
"PUB00159995"
] | [
"9115275",
"11577081",
"32761064"
] | [
"MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.",
"Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.",
"Bial... | [
1997,
2001,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
5452
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
50,
12,
10,
13,
8
] | 6 | true | Domain | MAP kinase-activating death domain protein, C-terminal PH-like domain | MAP kinase-activating death domain protein, C-terminal PH-like domain | PH_MADD | 8 |
IPR057470 | 57,470 | CFAP65, seventh Ig-like domain | Ig_CFAP65_7th | Domain | 1,325 | false | false | This entry represents the seventh Ig-like domain of CFAP65 and related sequences. Cilia-Flagella-Associated Protein 65 (CFAP65) is involved in the structural and functional integrity of cilia and flagella. This protein is implicated in the process of flagellar formation and is essential for proper sperm motility, sugge... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25249"
] | [
"Ig_CFAP65_7th"
] | [
1325
] | 1 | [] | [] | [] | 0 | [
"7n61",
"7som",
"9ijj"
] | 3 | [
"PUB00155585",
"PUB00160504"
] | [
"33472045",
"22761584"
] | [
"Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.",
"The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility."
] | [
2021,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1325
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
2,
2
] | 4 | true | Domain | CFAP65, seventh Ig-like domain | CFAP65, seventh Ig-like domain | Ig_CFAP65_7th | 6 |
IPR057471 | 57,471 | CHMP7, winged helix domain | CHMP7_WHD | Domain | 1,165 | false | false | This entry represents the winged helix domain in CHMP7 and similar animal proteins. Charged multivesicular body protein 7 (CHMP7) is an endosomal sorting complex required for transport (ESCRT)-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. It plays a role in the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25239"
] | [
"WHD_CHMP7"
] | [
1165
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-1632852",
"R-DRE-917729",
"R-DRE-9668328",
"R-GGA-1632852",
"R-GGA-5620971",
"R-GGA-917729",
"R-GGA-9668328",
"R-HSA-162588",
"R-HSA-1632852",
"R-HSA-5620971",
"R-HSA-917729",
"R-HSA-9610379",
"R-HSA-9615710",
"R-HSA-9668328",
"R-HSA-9679504",
"R-HSA-9694676",
"R-MMU-1632852",... | [
"REACTOME:R-DRE-1632852",
"REACTOME:R-DRE-917729",
"REACTOME:R-DRE-9668328",
"REACTOME:R-GGA-1632852",
"REACTOME:R-GGA-5620971",
"REACTOME:R-GGA-917729",
"REACTOME:R-GGA-9668328",
"REACTOME:R-HSA-162588",
"REACTOME:R-HSA-1632852",
"REACTOME:R-HSA-5620971",
"REACTOME:R-HSA-917729",
"REACTOME:R-... | 23 | [] | 0 | [
"PUB00160205",
"PUB00160206"
] | [
"26040712",
"28242692"
] | [
"Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.",
"LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells."
] | [
2015,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1165
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
1,
3
] | 5 | true | Domain | CHMP7, winged helix domain | CHMP7, winged helix domain | CHMP7_WHD | 7 |
IPR057473 | 57,473 | CPL3, ARM repeat | ARM_CPL3 | Domain | 653 | false | false | This entry represents an ARM repeat in RNA polymerase II C-terminal domain phosphatase-like 3 (CPL3). Its precise function is unknown. CPL3 plays an important role in plant development and defence mechanisms of Arabidopsis thaliana. CPL3 acts as a negative regulator of immune gene expression and immunity to pathogen in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25505"
] | [
"ARM_CPL3"
] | [
653
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160106",
"PUB00160107"
] | [
"25464831",
"38594216"
] | [
"Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity.",
"C-TERMINAL DOMAIN PHOSPHATASE-LIKE 3 contributes to GA-mediated growth and flowering by interaction with DELLA proteins."
] | [
2014,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
653
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
4,
5
] | 3 | true | Domain | CPL3, ARM repeat | CPL3, ARM repeat | ARM_CPL3 | 7 |
IPR057475 | 57,475 | Cuticlin, C-terminal domain | CUT_C | Domain | 4,694 | false | false | This entry represents the C-terminal Ig-like domain of Cuticlin proteins from Caenorhabditis elegans. This model doesn't capture the C-terminal strand that, in some of the proteins, is separated by a large irregular insertion. Cuticlin is a component of the cuticles, which contributes to the formation of extracellular ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25301"
] | [
"CUT_C"
] | [
4694
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159889",
"PUB00159890",
"PUB00159891"
] | [
"1864469",
"15936343",
"30409788"
] | [
"cut-1 a Caenorhabditis elegans gene coding for a dauer-specific noncollagenous component of the cuticle.",
"The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans.",
"Epidermal Remodeling in <i>Caenorhabditis e... | [
1991,
2005,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
4694
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
35,
4
] | 2 | true | Domain | Cuticlin, C-terminal domain | Cuticlin, C-terminal domain | CUT_C | 2 |
IPR057476 | 57,476 | Cux, N-terminal domain | Cux_N | Domain | 5,784 | false | false | This domain is found at the N-terminal in Homeobox protein cut-like (Cux) 1 and 2 and similar eukaryotic proteins. This domain is predicted to adopt an α-helical configuration. Cux1 (also known as Cutl1) and Cux2 are transcription factors involved in the control of neuronal differentiation in the brain. They regulate d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25398"
] | [
"CUX1_N"
] | [
5784
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1839117",
"R-HSA-5655302",
"R-HSA-6811438"
] | [
"REACTOME:R-HSA-1839117",
"REACTOME:R-HSA-5655302",
"REACTOME:R-HSA-6811438"
] | 3 | [] | 0 | [
"PUB00016380",
"PUB00160742",
"PUB00160743",
"PUB00160744",
"PUB00160745"
] | [
"12429822",
"20510857",
"1301999",
"15656993",
"7910552"
] | [
"CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.",
"Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex.",
"Human CCAAT displacement p... | [
2002,
2010,
1992,
2005,
1993
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Roseofilum reptotaenium AO1-A"
] | [
5783,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
4,
2,
18,
11,
17,
1,
5,
15,
1,
1,
5
] | 11 | true | Domain | Cux, N-terminal domain | Cux, N-terminal domain | Cux_N | 8 |
IPR057478 | 57,478 | DAAF9, domain 2 | DAAF9_2 | Domain | 1,085 | false | false | This domain is found in DAAF9 and related proteins. This domain is found C-terminal to which is also predicted to show an α-β configuration. Dynein axonemal assembly factor 9 DNAAF9 (Shulin) is a dynein axonemal assembly factor that regulates the transport and activation of outer dynein arms (ODAs) in cilia. It binds a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25204"
] | [
"DAAF9_2"
] | [
1085
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00109577"
] | [
"33632841"
] | [
"Shulin packages axonemal outer dynein arms for ciliary targeting."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1085
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
5
] | 4 | true | Domain | DAAF9, domain 2 | DAAF9, domain 2 | DAAF9_2 | 7 |
IPR057479 | 57,479 | PRP28/DDX23-like, helical domain | PRP28/DDX23-like_helical | Domain | 4,197 | false | false | This short domain is found in DDX23, Pre-mRNA-splicing ATP-dependent RNA helicase (PRP28) and related proteins. This domain adopts an α-helical structure and is usually associated with and . The PRP28 and DDX23 proteins are ATP-dependent RNA helicases that play a crucial role in pre-mRNA splicing. These helicases are i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25430"
] | [
"DDX23"
] | [
4197
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.6.4.13",
"R-HSA-72163",
"R-HSA-72165"
] | [
"EC:3.6.4.13",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165"
] | 3 | [
"3jcr",
"6ah0",
"6qw6",
"6qx9",
"8h6e",
"8h6j",
"8q7w",
"8q7x",
"8q91",
"8qoz",
"8qp8",
"8qp9",
"8qpa",
"8qpb",
"8qpk",
"8qxd",
"8r08",
"8r09",
"8r0a",
"8r0b",
"8rc0",
"8rm5",
"8y6o"
] | 23 | [
"PUB00130709",
"PUB00144944"
] | [
"18425142",
"28076779"
] | [
"Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.",
"Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation."
] | [
2008,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4197
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
7,
1,
2,
2,
7,
1,
1,
1,
5,
1,
11
] | 11 | true | Domain | PRP28/DDX23-like, helical domain | PRP28/DDX23-like, helical domain | PRP28/DDX23-like_helical | 3 |
IPR057480 | 57,480 | Microtubule-associated protein 1A/B/S-like, MBL-like domain | MAP1A/B/S-like_MBL | Domain | 4,094 | false | false | This domain is found in the Microtubule-associated proteins MAP1B, MAP1A, MAP1S and related animal proteins. MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension [ ]. MAP1S mediates aggregation of mitochondria result... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25281"
] | [
"MBL_MAP1B"
] | [
4094
] | 1 | [
"REACTOME"
] | [
"R-HSA-9833110"
] | [
"REACTOME:R-HSA-9833110"
] | 1 | [
"9ijj"
] | 1 | [
"PUB00059964",
"PUB00155731"
] | [
"17234756",
"33268592"
] | [
"Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities.",
"Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss."
] | [
2007,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4094
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
4,
18,
13,
13
] | 5 | true | Domain | Microtubule-associated protein 1A/B/S-like, MBL-like domain | Microtubule-associated protein 1A/B/S-like, MBL-like domain | MAP1A/B/S-like_MBL | 1 |
IPR057481 | 57,481 | Decapeptide repeat | Decapeptide | Repeat | 459 | false | false | This entry corresponds to a region composed of a 10 residue repeat that forms an α-helical solenoid structure found in uncharacterised eukaryotic proteins and putative IcmE proteins in bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25296"
] | [
"Decapeptide"
] | [
459
] | 1 | [] | [] | [] | 0 | [
"7muc",
"7mue",
"7muq",
"7mus",
"7muv",
"7muw",
"7muy",
"9ngv",
"9ngw",
"9ngy",
"9nh0"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
135,
320,
2,
2
] | 4 | [] | [] | 0 | true | Repeat | Decapeptide repeat | Decapeptide repeat | Decapeptide | 3 |
IPR057482 | 57,482 | Dep-1, third Fn3-like domain | Fn3_Dep-1_3rd | Domain | 131 | false | false | This entry represents the third Fn3-like domain. This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the β-integrin subunit pat-3. It is involved in the regulation of the cell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25300"
] | [
"Fn3_Dep-1_3rd"
] | [
131
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-CEL-6807004"
] | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807004"
] | 2 | [] | 0 | [
"PUB00159896",
"PUB00159897"
] | [
"15901674",
"28135265"
] | [
"The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.",
"β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans."
] | [
2005,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
131
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Dep-1, third Fn3-like domain | Dep-1, third Fn3-like domain | Fn3_Dep-1_3rd | 3 |
IPR057483 | 57,483 | Mechanosensitive channel protein 2/3, transmembrane domain | MSL2/3_TM_dom | Domain | 1,383 | false | false | This domain is found in Mechanosensitive ion channel protein 2 and 3 from Arabidopsis thaliana (MSL2/3) and similar plant sequences. MSL2/3 control plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension [ ]. This domain is predicted to c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25237"
] | [
"MSL2_3"
] | [
1383
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159912"
] | [
"16401419"
] | [
"MscS-like proteins control plastid size and shape in Arabidopsis thaliana."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria bacterium LSUCC0057",
"Streptophyta"
] | [
1,
1382
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
4,
6
] | 3 | true | Domain | Mechanosensitive channel protein 2/3, transmembrane domain | Mechanosensitive channel protein 2/3, transmembrane domain | MSL2/3_TM_dom | 3 |
IPR057484 | 57,484 | Diatom pyrenoid component 1, conserved motif | DPC1 | Conserved_site | 11 | false | false | DPC1 is localised at the pyrenoid matrix/stroma interface in diatoms [ ]. This entry represents a conserved motif found in DPC1 and its homologues. The function is currently unknown but could be a short linear motif involved in a protein-protein interaction. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25193"
] | [
"DPC1"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160127"
] | [
"39368476"
] | [
"A protein blueprint of the diatom CO<sub>2</sub>-fixing organelle."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Thalassiosirophycidae"
] | [
11
] | 1 | [] | [] | 0 | true | Conserved_site | Diatom pyrenoid component 1, conserved motif | Diatom pyrenoid component 1, conserved motif | DPC1 | 7 |
IPR057485 | 57,485 | Moderate conductance mechanosensitive channel YbiO-like, transmembrane helix 1 | YbiO-like_TM1 | Domain | 2,790 | false | false | This entry represents the first transmembrane helix (TM1) domain of Moderate conductance mechanosensitive channel YbiO from Moderate conductance mechanosensitive channel YbiO and similar small conductance mechanosensitive channels (MscS) found in proteobacteria. YbiO protects cells against hypoosmotic stress when highl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25392"
] | [
"MS_channel_TM1"
] | [
2790
] | 1 | [] | [] | [] | 0 | [
"7a46",
"9go3"
] | 2 | [
"PUB00019883",
"PUB00019884",
"PUB00019885",
"PUB00062568",
"PUB00064132",
"PUB00101037",
"PUB00160157"
] | [
"11296222",
"11159397",
"11275684",
"23012406",
"23074248",
"23339071",
"33148804"
] | [
"Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii.",
"Molecular identification of a mechanosensitive channel in archaea.",
"Mechanosensitive channels in prokaryotes.",
"Conformational state of the MscS mechanosensitive channel in solution revea... | [
2001,
2001,
2001,
2012,
2012,
2013,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5",
"unclassified sequences"
] | [
2771,
1,
18
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Moderate conductance mechanosensitive channel YbiO-like, transmembrane helix 1 | Moderate conductance mechanosensitive channel YbiO-like, transmembrane helix 1 | YbiO-like_TM1 | 2 |
IPR057486 | 57,486 | Diatom pyrenoid component 2 | DPC2 | Domain | 37 | false | false | This entry represents a conserved motif within DPC2 and its homologues. DCP2 localises to the pyrenoid matrix in diatoms and interacts with Rubisco. It is relatively abundant, suggesting a potential role in matrix assembly/organisation [ ]. The region defined here contains multiple HxxYLDxxH motifs, where H means hydro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25195"
] | [
"DPC2"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160127"
] | [
"39368476"
] | [
"A protein blueprint of the diatom CO<sub>2</sub>-fixing organelle."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillariophyta"
] | [
37
] | 1 | [] | [] | 0 | true | Domain | Diatom pyrenoid component 2 | Diatom pyrenoid component 2 | DPC2 | 2 |
IPR057487 | 57,487 | Diatom pyrenoid component 3 | DPC3 | Family | 1 | false | false | DPC3 localises to the pyrenoid periphery and co-localises with Shell4. DPC3 may act as an intermediary between the Rubisco matrix and the shell [ ]. It has low abundance compared to Shell proteins and shows no structural similarity to Shell proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25194"
] | [
"DPC3"
] | [
1
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160127"
] | [
"39368476"
] | [
"A protein blueprint of the diatom CO<sub>2</sub>-fixing organelle."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Thalassiosira pseudonana"
] | [
1
] | 1 | [] | [] | 0 | true | Family | Diatom pyrenoid component 3 | Diatom pyrenoid component 3 | DPC3 | 8 |
IPR057488 | 57,488 | Diatom pyrenoid component 4, C-terminal motif | DPC4_C | Conserved_site | 2 | false | false | This entry represents a small motif found in two copies at the C-terminal of DPC4. DPC4 localises throughout the pyrenoid matrix in diatoms. Shows matrix-type localisation and interacts with Shell4 and Rubisco but function currently unknown. May have a role in matrix assembly/organisation. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25196"
] | [
"DPC4_C"
] | [
2
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160127"
] | [
"39368476"
] | [
"A protein blueprint of the diatom CO<sub>2</sub>-fixing organelle."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Thalassiosira pseudonana"
] | [
2
] | 1 | [] | [] | 0 | true | Conserved_site | Diatom pyrenoid component 4, C-terminal motif | Diatom pyrenoid component 4, C-terminal motif | DPC4_C | 9 |
IPR057489 | 57,489 | Menorin, C-terminal domain | Menorin_C | Domain | 196 | false | false | This entry represents the C-terminal domain of Menorin from C. elegans and related sequences mainly from nematodes. This domain may adopt a β-sandwich fold comprising 14 antiparallel β-strands. Menorin is involved in generation of neurons and regulation of dendrite extension [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25161"
] | [
"Menorin_C"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160151",
"PUB00160152"
] | [
"24120132",
"24120131"
] | [
"Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.",
"An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis."
] | [
2013,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
196
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Menorin, C-terminal domain | Menorin, C-terminal domain | Menorin_C | 5 |
IPR057490 | 57,490 | Diatom pyrenoid component 4, N-terminal motif | DPC4_N | Conserved_site | 8 | false | false | This entry represents a short N-terminal motif that is found in two copies in DPC4. DPC4 localises throughout the pyrenoid matrix in diatoms. Shows matrix-type localisation and interacts with Shell4 and Rubisco but function currently unknown. May have a role in matrix assembly/organisation. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25197"
] | [
"DPC4_N"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160127"
] | [
"39368476"
] | [
"A protein blueprint of the diatom CO<sub>2</sub>-fixing organelle."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Thalassiosirophycidae"
] | [
8
] | 1 | [] | [] | 0 | true | Conserved_site | Diatom pyrenoid component 4, N-terminal motif | Diatom pyrenoid component 4, N-terminal motif | DPC4_N | 2 |
IPR057492 | 57,492 | Metal transporter CNNM1/2/4, immunoglobulin-like domain | Ig_CNNM1/2/4_N | Domain | 3,374 | false | false | This domain is found at the N-terminal end of human Metal transporter CNNM1/2/4 and similar proteins mainly found in vertebrates. CNNM4 may play a role in sensory neuron functions and in biomineralisation and retinal function [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25511"
] | [
"Ig_CNNM4_N"
] | [
3374
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160505",
"PUB00160506"
] | [
"19200525",
"19200527"
] | [
"Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta.",
"Mutations in CNNM4 cause recessive cone-rod dystrophy with amelogenesis imperfecta."
] | [
2009,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3374
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
4,
5,
9
] | 4 | true | Domain | Metal transporter CNNM1/2/4, immunoglobulin-like domain | Metal transporter CNNM1/2/4, immunoglobulin-like domain | Ig_CNNM1/2/4_N | 5 |
IPR057493 | 57,493 | PH-like domain, RdRP associated | PH_RdRP-assoc | Domain | 548 | false | false | This entry represents a PH-like domain found towards the N terminus of some predicted metazoan RNA-dependent RNA polymerases. This domain appears to have similar domain organisation to found in fungi. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25359"
] | [
"PH_met_RdRP"
] | [
548
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
548
] | 1 | [
"Caenorhabditis elegans"
] | [
5
] | 1 | true | Domain | PH-like domain, RdRP associated | PH-like domain, RdRP associated | PH_RdRP-assoc | 9 |
IPR057494 | 57,494 | [F-actin]-monooxygenase MICAL1-3-like, Rossman domain | Rossman_Mical | Domain | 8,144 | false | false | This domain is found towards the N terminus of a group of animal monooxygenases that play a crucial role in the regulation of the actin cytoskeleton, including [F-actin]-monooxygenase MICAL1-3 from humans. These enzymes promote the depolymerisation of F-actin by oxidising specific methionine residues on actin, leading ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25413"
] | [
"Rossman_Mical"
] | [
8144
] | 1 | [
"EC",
"REACTOME"
] | [
"1.14.13.225",
"R-HSA-983231"
] | [
"EC:1.14.13.225",
"REACTOME:R-HSA-983231"
] | 2 | [
"2bra",
"2bry",
"2c4c",
"4txi",
"4txk",
"6ici",
"8y6k",
"9ewy"
] | 8 | [
"PUB00039729",
"PUB00039737",
"PUB00071350",
"PUB00160181",
"PUB00160182",
"PUB00160507",
"PUB00160508"
] | [
"16275926",
"16275925",
"24440334",
"31949908",
"39122694",
"29343822",
"34106209"
] | [
"Structure and activity of the axon guidance protein MICAL.",
"High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.",
"Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.",
"Structural and kinetic insight... | [
2005,
2005,
2014,
2020,
2024,
2018,
2021
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8144
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
169,
6,
7,
9,
14
] | 5 | true | Domain | [F-actin]-monooxygenase MICAL1-3-like, Rossman domain | [F-actin]-monooxygenase MICAL1-3-like, Rossman domain | Rossman_Mical | 1 |
IPR057495 | 57,495 | Mitochondrial chaperone BCS1-like, ATPase lid domain | AAA_lid_BCS1 | Domain | 8,205 | false | false | This ATPase lid domain is found at the C-terminal end of human Mitochondrial chaperone BCS1 and similar eukaryotic proteins. BCS1 is a chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III. It plays an important role in the maintenance of mi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25426"
] | [
"AAA_lid_BCS1"
] | [
8205
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289",
"R-HSA-1268020",
"R-HSA-9865881"
] | [
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289",
"REACTOME:R-HSA-1268020",
"REACTOME:R-HSA-9865881"
] | 13 | [
"6sh3",
"6sh4",
"6sh5",
"6u1y",
"6uko",
"6ukp",
"6uks",
"8t14",
"8t5u",
"8t7u",
"8tby",
"8ti0",
"8tp1",
"8tpl",
"9gs2",
"9gsn",
"9gu9"
] | 17 | [
"PUB00063313",
"PUB00063316",
"PUB00160091",
"PUB00160092",
"PUB00160509"
] | [
"18628306",
"11528392",
"32042153",
"38821922",
"9878253"
] | [
"Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.",
"A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.",
"Structures... | [
2008,
2001,
2020,
2024,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Imitervirales",
"metagenomes"
] | [
41,
8147,
11,
6
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
2,
5,
1,
3,
3,
1,
1
] | 9 | true | Domain | Mitochondrial chaperone BCS1-like, ATPase lid domain | Mitochondrial chaperone BCS1-like, ATPase lid domain | AAA_lid_BCS1 | 1 |
IPR057496 | 57,496 | FAN-like, N-terminal PH domain | FAN-like_PH | Domain | 2,142 | false | false | This entry represents the pleckstrin homology (PH) domain found at the N-terminal of the Factor Associated with Neutral sphingomyelinase activation (FAN) protein and its orthologue BEACH domain-containing protein lvsF in Dictyostelium discoideum. The PH domain binds specifically to phosphatidylinositol 4,5-bisphosphate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25400"
] | [
"PH_FAN"
] | [
2142
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5626978",
"R-MMU-5626978"
] | [
"REACTOME:R-HSA-5626978",
"REACTOME:R-MMU-5626978"
] | 2 | [] | 0 | [
"PUB00018199",
"PUB00160161",
"PUB00160510",
"PUB00160511",
"PUB00160512",
"PUB00160513"
] | [
"12234919",
"20534702",
"17599063",
"11435466",
"12391233",
"18653803"
] | [
"Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.",
"FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.",
"PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-indu... | [
2002,
2010,
2007,
2001,
2002,
2008
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2142
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
4,
12
] | 4 | true | Domain | FAN-like, N-terminal PH domain | FAN-like, N-terminal PH domain | FAN-like_PH | 6 |
IPR057498 | 57,498 | Rtel1 helicase, ARCH domain | Rtel1_ARCH | Domain | 3,015 | false | false | This domain is found in Regulator of telomere elongation helicase 1. The ARCH domain follows the N-terminal Rad3-like domain ([ ]). The structure of the ARCH domain is predicted to share similarity with the ARCH domain of XPD despite low sequence similarity and to contain a four-stranded antiparallel β-sheet with four ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23109"
] | [
"ARCH_RTEL1"
] | [
3015
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.-",
"R-HSA-171319",
"R-HSA-2564830",
"R-HSA-5693554",
"R-MMU-171319",
"R-RNO-171319"
] | [
"EC:5.6.2.-",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-2564830",
"REACTOME:R-HSA-5693554",
"REACTOME:R-MMU-171319",
"REACTOME:R-RNO-171319"
] | 6 | [] | 0 | [
"PUB00074118",
"PUB00074223",
"PUB00074225",
"PUB00074226",
"PUB00074228",
"PUB00103976",
"PUB00133413",
"PUB00133415",
"PUB00133416",
"PUB00153326",
"PUB00155503"
] | [
"24009516",
"18957201",
"25628358",
"24582487",
"25620558",
"34644293",
"23329068",
"19578366",
"22886559",
"35320499",
"26847928"
] | [
"A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.",
"RTEL1 maintains genomic stability by suppressing homologous recombination.",
"Human regulator of telomere elongation helicase 1 (RTEL1) is requ... | [
2013,
2008,
2015,
2014,
2015,
2021,
2013,
2009,
2012,
2022,
2016
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3015
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
3,
2,
3,
2,
1,
3,
15
] | 9 | true | Domain | Rtel1 helicase, ARCH domain | Rtel1 helicase, ARCH domain | Rtel1_ARCH | 4 |
IPR057499 | 57,499 | FKB95-like, N-terminal Kelch domain | Kelch_FKB95 | Domain | 6,712 | false | false | This entry represents the N-terminal Kelch domain found in plant proteins that are also associated with a F-box domain ( ), such as FKB95 from Arabidopsis thaliana, also known as At1g61540. FKB95 is a component of SCF (ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25210"
] | [
"Kelch_FKB95"
] | [
6712
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160516",
"PUB00160517"
] | [
"31898225",
"33010352"
] | [
"The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases.",
"The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway."
] | [
2020,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Eukaryota"
] | [
11,
6701
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
318,
18,
9
] | 3 | true | Domain | FKB95-like, N-terminal Kelch domain | FKB95-like, N-terminal Kelch domain | Kelch_FKB95 | 6 |
IPR057500 | 57,500 | DCK1-like, fourth C2 domain | C2_DCK1_4th | Domain | 211 | false | false | This entry represents the C2 domain found in the dock-like protein 1 (DCK1) from Saccharomyces cerevisiae and similar fungal proteins. C2 domains typically function as calcium-dependent membrane-targeting modules. The domain is found in proteins related to membrane trafficking. DCK1 forms a transient heterodimeric comp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25338"
] | [
"C2_DCK_4th"
] | [
211
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-6798695",
"R-SCE-983231"
] | [
"REACTOME:R-SCE-6798695",
"REACTOME:R-SCE-983231"
] | 2 | [] | 0 | [
"PUB00014935",
"PUB00073862",
"PUB00073863",
"PUB00074400"
] | [
"12432077",
"15723800",
"25022758",
"25598154"
] | [
"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.",
"A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.",
"Dock-family exchange factors in cell migration and disease.",
"Identification ... | [
2002,
2005,
2014,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
211
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | DCK1-like, fourth C2 domain | DCK1-like, fourth C2 domain | C2_DCK1_4th | 5 |
IPR057501 | 57,501 | Deubiquitinating enzyme, PH domain | DeUb_enz_PH | Domain | 424 | false | false | This entry represents the PH domain of a group of uncharacterised fungal proteins that contain a peptidase C48 domain ( ). This suggests that these proteins may overall function as deubiquitinating enzymes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25424"
] | [
"PH_35"
] | [
424
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
424
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Deubiquitinating enzyme, PH domain | Deubiquitinating enzyme, PH domain | DeUb_enz_PH | 9 |
IPR057502 | 57,502 | PH-like domain, fungal | PH_25 | Domain | 20 | false | false | This entry represents a PH domain found in uncharacterised actinomycete proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25380"
] | [
"PH_25"
] | [
20
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Onygenales"
] | [
20
] | 1 | [] | [] | 0 | true | Domain | PH-like domain, fungal | PH-like domain, fungal | PH_25 | 5 |
IPR057503 | 57,503 | RdRP-like, PH domain | PH_RdRP | Domain | 938 | false | false | This entry represents a PH-like domain found at the N-terminal in a group of predicted RNA-dependent RNA polymerases from actinomycetes that also contain . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25358"
] | [
"PH_fung_RdRP"
] | [
938
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
938
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | RdRP-like, PH domain | RdRP-like, PH domain | PH_RdRP | 6 |
IPR057505 | 57,505 | SH3b, T C-terminal domain | SH3b_T_C | Domain | 133 | false | false | This domain is found twice towards the C-terminal end of the staphylococcal phage protein (IPLA5_0029) and in similar peptidoglycan-degrading enzymes mainly from bacteriophages. This domain, found associated with and in some members of this group, is involved in the binding of ligands at the bacterial surface. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24246"
] | [
"SH3b_T"
] | [
133
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"human gut metagenome"
] | [
84,
47,
2
] | 3 | [] | [] | 0 | true | Domain | SH3b, T C-terminal domain | SH3b, T C-terminal domain | SH3b_T_C | 2 |
IPR057506 | 57,506 | GPCPD1-like, C2 domain | C2_GPCPD1 | Domain | 5,431 | false | false | This entry represents the C2 domain in GPCPD1 and related proteins such as GDE1 its orthologue in fungi. C2 domains are protein structural domains involved in targeting proteins to cell membranes, often in a calcium-dependent manner. This domain likely helps localise the phosphodiesterase activity to cellular membranes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25329"
] | [
"C2_GDE1"
] | [
5431
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.4.2",
"PWY-7367",
"PWY-7409",
"R-HSA-1483115",
"R-HSA-1483152",
"R-SCE-204005",
"R-SCE-3295583",
"R-SCE-983168"
] | [
"EC:3.1.4.2",
"METACYC:PWY-7367",
"METACYC:PWY-7409",
"REACTOME:R-HSA-1483115",
"REACTOME:R-HSA-1483152",
"REACTOME:R-SCE-204005",
"REACTOME:R-SCE-3295583",
"REACTOME:R-SCE-983168"
] | 8 | [] | 0 | [
"PUB00072568",
"PUB00078950"
] | [
"20576599",
"16141200"
] | [
"A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism.",
"Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae."
] | [
2010,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5431
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
13,
3,
1,
2,
2,
6,
2,
1
] | 9 | true | Domain | GPCPD1-like, C2 domain | GPCPD1-like, C2 domain | C2_GPCPD1 | 7 |
IPR057508 | 57,508 | SHC SH2 domain-binding protein 1-like, N-terminal domain | SHCBP-like_N | Domain | 1,587 | false | false | This entry represents the N-terminal domain of SHC SH2 domain-binding protein 1 (SHCBP) and related sequences from animals such as SHCBA-B, SHP1L and NESD. SHCBP is involved in the regulation of multiple signalling pathways, such as FGF, NF-kB, MAPK/ERK, PI3K/AKT, TGF-beta/Smad and beta-catenin signalling. SHCBP partic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23762"
] | [
"SHCBP_N"
] | [
1587
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098120",
"PUB00155841",
"PUB00155842",
"PUB00155843"
] | [
"22508726",
"35013128",
"31250756",
"10086341"
] | [
"The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.",
"EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation.",
"The Role of Shcbp1 in Signaling and Disease.",
"Cloning and ch... | [
2012,
2022,
2019,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1587
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
5,
5,
7
] | 5 | true | Domain | SHC SH2 domain-binding protein 1-like, N-terminal domain | SHC SH2 domain-binding protein 1-like, N-terminal domain | SHCBP-like_N | 8 |
IPR057509 | 57,509 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain | C2_SHIP1-2_2nd | Domain | 3,289 | false | false | This entry represents the second C2 domain of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatases 1/2 [ ] and similar proteins from vertebrates. The C2 domains of these proteins modulate the activity of the phosphatase domain. Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (SHIP) specifically hydrol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24147"
] | [
"C2_SHIP1-2_2nd"
] | [
3289
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"3.1.3",
"3.1.3.86",
"PWY-6368",
"R-CFA-1660499",
"R-CFA-1855204",
"R-CFA-912526",
"R-DRE-1660499",
"R-DRE-1855204",
"R-HSA-1660499",
"R-HSA-1855204",
"R-HSA-202424",
"R-HSA-210990",
"R-HSA-912526",
"R-HSA-9680350",
"R-MMU-1660499",
"R-MMU-1855204",
"R-MMU-202424",
"R-MMU-210990",
... | [
"EC:3.1.3",
"EC:3.1.3.86",
"METACYC:PWY-6368",
"REACTOME:R-CFA-1660499",
"REACTOME:R-CFA-1855204",
"REACTOME:R-CFA-912526",
"REACTOME:R-DRE-1660499",
"REACTOME:R-DRE-1855204",
"REACTOME:R-HSA-1660499",
"REACTOME:R-HSA-1855204",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-210990",
"REACTOME:R-HS... | 24 | [
"5okm",
"5okn",
"5oko",
"5okp",
"5rw2",
"5rw3",
"5rw4",
"5rw5",
"5rw6",
"5rw7",
"5rw8",
"5rw9",
"5rwa",
"5rwb",
"5rwc",
"5rwd",
"5rwe",
"5rwf",
"5rwg",
"5rwh",
"5rwi",
"5rwj",
"5rwk",
"5rwl",
"5rwm",
"5rwn",
"5rwo",
"5rwp",
"5rwq",
"5rwr",
"5rws",
"5rwt"... | 103 | [
"PUB00101560",
"PUB00123615",
"PUB00125524",
"PUB00155561",
"PUB00160518"
] | [
"10764818",
"8723348",
"8769125",
"38309262",
"16682172"
] | [
"The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.",
"Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.",
"Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phospha... | [
2000,
1996,
1996,
2024,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3289
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
3,
5,
15
] | 4 | true | Domain | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, second C2 domain | C2_SHIP1-2_2nd | 7 |
IPR057510 | 57,510 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain | C2_SHIP1-2_first | Domain | 3,149 | false | false | This entry represents the first C2 domain of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatases 1/2 [ ] and similar proteins from vertebrates. The C2 domains of these proteins modulate the activity of the phosphatase domain. Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (SHIP) specifically hydroly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24150"
] | [
"C2_SHIP1-2_first"
] | [
3149
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"3.1.3",
"3.1.3.86",
"PWY-6368",
"R-CFA-1660499",
"R-CFA-1855204",
"R-CFA-912526",
"R-DRE-1660499",
"R-DRE-1855204",
"R-HSA-1660499",
"R-HSA-1855204",
"R-HSA-202424",
"R-HSA-210990",
"R-HSA-912526",
"R-HSA-9680350",
"R-MMU-1660499",
"R-MMU-1855204",
"R-MMU-202424",
"R-MMU-210990",
... | [
"EC:3.1.3",
"EC:3.1.3.86",
"METACYC:PWY-6368",
"REACTOME:R-CFA-1660499",
"REACTOME:R-CFA-1855204",
"REACTOME:R-CFA-912526",
"REACTOME:R-DRE-1660499",
"REACTOME:R-DRE-1855204",
"REACTOME:R-HSA-1660499",
"REACTOME:R-HSA-1855204",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-210990",
"REACTOME:R-HS... | 24 | [] | 0 | [
"PUB00101560",
"PUB00123615",
"PUB00125524",
"PUB00155561",
"PUB00160518"
] | [
"10764818",
"8723348",
"8769125",
"38309262",
"16682172"
] | [
"The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.",
"Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.",
"Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phospha... | [
2000,
1996,
1996,
2024,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3149
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
4,
3,
15
] | 4 | true | Domain | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1/2-like, first C2 domain | C2_SHIP1-2_first | 3 |
IPR057511 | 57,511 | GDS1, winged helix domain | WH_GDS1 | Domain | 1,539 | false | false | This entry represents a winged helix DNA-binding domain in GDS1 and related fungal proteins. Winged helix domains are a subclass of the helix-turn-helix domains that include additional β-strand "wings". These domains are commonly involved in sequence-specific DNA recognition and binding. The GDS1 proteins are involved ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25318"
] | [
"WHD_GDS1"
] | [
1539
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042821"
] | [
"14562106"
] | [
"Global analysis of protein expression in yeast."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1539
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | GDS1, winged helix domain | GDS1, winged helix domain | WH_GDS1 | 8 |
IPR057512 | 57,512 | RTG2, C-terminal domain | RTG2_C | Domain | 1,615 | false | false | This domain is found C-terminal in the yeast Retrograde regulation protein 2 (RTG2) and related proteins. This domain shares significant similarity with known HD/PDEase domains and it is predicted to adopt similar structure. RTG2 is required for controlling the interorganelle communication between mitochondria, peroxis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23566"
] | [
"RTG2_C"
] | [
1615
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00068253"
] | [
"8422683"
] | [
"RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
1615
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | RTG2, C-terminal domain | RTG2, C-terminal domain | RTG2_C | 4 |
IPR057513 | 57,513 | Rv1893-like | Rv1893 | Family | 207 | false | false | This protein family includes a group of short sequences from actinomycetes, including Rv1893 from Mycobacterium tuberculosis ( ) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23706"
] | [
"Rv1893"
] | [
207
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155614"
] | [
"36243697"
] | [
"Comparative genome analysis of mycobacteria focusing on tRNA and non-coding RNA."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
207
] | 1 | [] | [] | 0 | true | Family | Rv1893-like | Rv1893-like | Rv1893 | 7 |
IPR057514 | 57,514 | SigF-like, NTF2-like domain | NTF2_SigF | Domain | 1,746 | false | false | This domain is found in the SrfA-induced gene F protein (SigF) from Dictyostelium discoideum and related proteins mainly found in fungi. SigF was identified amongst genes whose expression is dependent on the MADS box transcription factor SrfA and are induced late in development [ ]. This domain has a detectable similar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24840"
] | [
"NTF2_SigF"
] | [
1746
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155763"
] | [
"15075287"
] | [
"Identification of genes dependent on the MADS box transcription factor SrfA in Dictyostelium discoideum development."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1746
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | SigF-like, NTF2-like domain | SigF-like, NTF2-like domain | NTF2_SigF | 2 |
IPR057515 | 57,515 | Signal transducer and activator of transcription b, N-terminal | STATB_N | Domain | 119 | false | false | This entry represents the N-terminal domain of Signal transducer and activator of transcription b (STATB) from C.elegans and similar proteins from nematodes. STATB can have a dual function, signal transduction and activation of transcription. It is required, together with with transcription factor elt-3, for up-regulat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24629"
] | [
"STATB_N"
] | [
119
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1059683",
"R-CEL-1169408",
"R-CEL-1251985",
"R-CEL-186763",
"R-CEL-201556",
"R-CEL-3249367",
"R-CEL-6783783",
"R-CEL-6785807",
"R-CEL-877300",
"R-CEL-877312",
"R-CEL-8854691",
"R-CEL-8875791",
"R-CEL-8983432",
"R-CEL-8984722",
"R-CEL-8985947",
"R-CEL-9008059",
"R-CEL-9020591",... | [
"REACTOME:R-CEL-1059683",
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-1251985",
"REACTOME:R-CEL-186763",
"REACTOME:R-CEL-201556",
"REACTOME:R-CEL-3249367",
"REACTOME:R-CEL-6783783",
"REACTOME:R-CEL-6785807",
"REACTOME:R-CEL-877300",
"REACTOME:R-CEL-877312",
"REACTOME:R-CEL-8854691",
"REACTOME:R-... | 23 | [] | 0 | [
"PUB00155852",
"PUB00155853"
] | [
"31735670",
"33259791"
] | [
"An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.",
"Innate Immunity Promotes Sleep through Epidermal Antimicrobial Peptides."
] | [
2020,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
119
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Signal transducer and activator of transcription b, N-terminal | Signal transducer and activator of transcription b, N-terminal | STATB_N | 3 |
IPR057517 | 57,517 | Single-strand DNA deaminase toxin A-like, C-terminal | SsdA-like_C | Domain | 562 | false | false | This domain is found at the C-terminal end of Single-strand DNA deaminase toxin A from Pseudomonas syringae (SsdA, ) and similar uncharacterised bacterial and fungal sequences. SsdA shows a typical α-β deaminase configuration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24120"
] | [
"SsdA_C"
] | [
562
] | 1 | [] | [] | [] | 0 | [
"7jtu",
"9c63",
"9c64"
] | 3 | [
"PUB00155849"
] | [
"33448264"
] | [
"An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
56,
506
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Single-strand DNA deaminase toxin A-like, C-terminal | Single-strand DNA deaminase toxin A-like, C-terminal | SsdA-like_C | 2 |
IPR057518 | 57,518 | GRPD, C-terminal domain | GRDP_C | Domain | 1,791 | false | false | This entry represents the C-terminal domain in GRDP1 and GRDP2 proteins. It has a Tubby C-terminal domain-like fold, with a β-barrel packed around a central α-helix. The β-barrels contain 10 or 12 strands. Glycine-rich domain-containing proteins (GRDPs) play a regulatory role in abscisic acid (ABA) signalling and toler... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25335"
] | [
"GRDP_C"
] | [
1791
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00077560",
"PUB00096853",
"PUB00160499"
] | [
"25653657",
"28285133",
"29568308"
] | [
"Overexpression of AtGRDP2, a novel glycine-rich domain protein, accelerates plant growth and improves stress tolerance.",
"Modification of AtGRDP1 gene expression affects silique and seed development in Arabidopsis thaliana.",
"Plant Glycine-Rich Proteins in Stress Response: An Emerging, Still Prospective Stor... | [
2014,
2017,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
1791
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
3,
18
] | 3 | true | Domain | GRPD, C-terminal domain | GRPD, C-terminal domain | GRDP_C | 9 |
IPR057520 | 57,520 | GRHL1/CP2, C-terminal domain | GRHL1/CP2_C | Domain | 10,576 | false | false | This domain is found at the C-terminal end of human Grainyhead-like protein 1 homolog (GRHL1), Transcription factor CP2-like protein 1 and similar animal and fungal proteins. This domain is normally found associated with . Grainyhead/CP2 are highly conserved transcription factors in metazoa that function as key regulat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25416"
] | [
"GRHL1_C"
] | [
10576
] | 1 | [
"REACTOME"
] | [
"R-HSA-1989781"
] | [
"REACTOME:R-HSA-1989781"
] | 1 | [] | 0 | [
"PUB00087355",
"PUB00087356",
"PUB00087357",
"PUB00087358",
"PUB00090637",
"PUB00090638",
"PUB00090639",
"PUB00090640",
"PUB00090641",
"PUB00090642"
] | [
"18787404",
"16648487",
"19902333",
"7828600",
"29309642",
"16831572",
"20398424",
"21187384",
"26069269",
"2792757"
] | [
"The fold recognition of CP2 transcription factors gives new insights into the function and evolution of tumor suppressor protein p53.",
"Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.",
"The male-determining gene SRY is a hybrid of DGCR8 and SOX3, and is regulated by the tr... | [
2008,
2006,
2010,
1995,
2018,
2006,
2010,
2011,
2015,
1989
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
10575,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
17,
3,
14,
14,
2,
20
] | 7 | true | Domain | GRHL1/CP2, C-terminal domain | GRHL1/CP2, C-terminal domain | GRHL1/CP2_C | 1 |
IPR057522 | 57,522 | DNA utilization protein HofO, C-terminal domain | HofO_C | Domain | 1,166 | false | false | This entry represents the C-terminal domain in HofO and related proteins found in Enterobacteriaceae. It shows structural similarity to the Type II secretion system protein EspM ( ). The HofO proteins are involved in the utilisation of extracellular DNA as a nutrient source. Proteins in this group play a crucial role i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25319"
] | [
"HofO"
] | [
1166
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00068649"
] | [
"16707682"
] | [
"Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrient."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
1164,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA utilization protein HofO, C-terminal domain | DNA utilization protein HofO, C-terminal domain | HofO_C | 6 |
IPR057523 | 57,523 | HTH three-helical bundle domain | HTH_74 | Domain | 550 | false | false | This HTH (helix-turn-helix) three-helical bundle domain is found in uncharacterised plant proteins. It has a very weak but detectable similarity to known HTH domains. It is predicted to fold into a three-helical bundle with an up-and-down anticlockwise topology and right-handed twist. This domain contains semi-conserve... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25370"
] | [
"HTH_74"
] | [
550
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
550
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
2,
5
] | 3 | true | Domain | HTH three-helical bundle domain | HTH three-helical bundle domain | HTH_74 | 9 |
IPR057524 | 57,524 | Csa3, HTH domain | HTH_Csa3 | Domain | 2,967 | false | false | This is a HTH domain found in CRISPR locus-related putative DNA-binding protein Csa3 from Saccharolobus solfataricus . This entry also includes uncharacterised archaeal and bacterial proteins such as HVO_A0114 from Haloferax volcanii. Csa3 proteins consist of two domains that intertwine to form a homodimer. The N-termi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25212"
] | [
"HVO_A0114"
] | [
2967
] | 1 | [] | [] | [] | 0 | [
"2wte",
"6w11",
"6wxq"
] | 3 | [
"PUB00055126",
"PUB00106905"
] | [
"21093452",
"35038453"
] | [
"The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.",
"Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems."
] | [
2011,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
791,
2075,
39,
5,
57
] | 5 | [] | [] | 0 | true | Domain | Csa3, HTH domain | Csa3, HTH domain | HTH_Csa3 | 5 |
IPR057525 | 57,525 | U3 small nucleolar RNA-associated protein 20, C-terminal | UTP20_C | Domain | 3,881 | false | false | This region of tetratricopeptide-like (TPR) repeats is found at the C-terminal end of eukaryotic proteins including U3 small nucleolar RNA-associated protein 20 from yeast and the human homologue, also known as Small subunit processome component 20 homolog or DRIM (Down-Regulated In Metastasis) ( ). DRIM is differentia... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23099"
] | [
"UTP20_C"
] | [
3881
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 5 | [
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rxu",
"6rxv",
"6rxx",
"6rxz",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"9g33",
"9n6v",
"9n6w",
"9n6x",
"9n6y",
"9n6z",
"9n70",
"9n72"... | 40 | [
"PUB00014724",
"PUB00014725",
"PUB00101284",
"PUB00101285",
"PUB00101286",
"PUB00151110"
] | [
"9673349",
"12837249",
"17498821",
"32943522",
"31378463",
"34516797"
] | [
"Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis.",
"A panoramic view of yeast noncoding RNA processing.",
"Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.",
"Cryo-EM structure of 90<i>S</i> small r... | [
1998,
2003,
2007,
2020,
2019,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3881
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
3,
2,
2,
2,
1,
1,
1,
1,
1,
14
] | 12 | true | Domain | U3 small nucleolar RNA-associated protein 20, C-terminal | U3 small nucleolar RNA-associated protein 20, C-terminal | UTP20_C | 7 |
IPR057527 | 57,527 | HVO_A0261-like, N-terminal domain | HVO_A0261-like_N | Domain | 2,282 | false | false | This entry represents the N-terminal HTH domain of a group of sequences mostly from archaea, such as HVO_A0261 ( ) from H. volcanii. This domain is associated to . This entry also includes some bacterial sequences. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25213"
] | [
"HVO_A0261_N"
] | [
2282
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rhynchospora breviuscula",
"ecological metagenomes"
] | [
2178,
92,
1,
11
] | 4 | [] | [] | 0 | true | Domain | HVO_A0261-like, N-terminal domain | HVO_A0261-like, N-terminal domain | HVO_A0261-like_N | 6 |
IPR057528 | 57,528 | Protein-tyrosine-phosphatase MKP1, C-terminal domain | MPK1_C | Domain | 1,027 | false | false | This domain represents the unique C-terminal extension found in plant Mitogen-activated protein kinase phosphatases (MPKs). The domain shows homology to members of the actin-binding gelsolin family, with highest similarity to villin. The domain is found across diverse plant species including Arabidopsis, maize, tomato ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25466"
] | [
"MPK1_gelsolin_C"
] | [
1027
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160156",
"PUB00160519",
"PUB00160520",
"PUB00160521"
] | [
"11274055",
"16913867",
"21447069",
"21790814"
] | [
"Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.",
"The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis.",
"Arabidopsis MAP Kinase Phosphatase 1 (AtMKP1) negatively regulates MPK6-mediated PAMP responses and r... | [
2001,
2006,
2011,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1027
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
5,
13
] | 3 | true | Domain | Protein-tyrosine-phosphatase MKP1, C-terminal domain | Protein-tyrosine-phosphatase MKP1, C-terminal domain | MPK1_C | 7 |
IPR057529 | 57,529 | MRCK/ROCK kinase, PH domain | MRCK/ROCK_PH | Domain | 11,037 | false | false | This entry represents a pleckstrin homology (PH) domain found in Serine/threonine-protein kinase MRCK alpha/beta/gamma, in Rho-associated protein kinase 1/2 (ROCK1/2) and similar sequences mainly found in animals. MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) forms part of a tripartite C1-PH-CNH regulat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25346"
] | [
"PH_MRCK"
] | [
11037
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11",
"R-CEL-9013149",
"R-CEL-9013406",
"R-DME-9013149",
"R-DME-9013406",
"R-HSA-111465",
"R-HSA-3928662",
"R-HSA-3928663",
"R-HSA-416482",
"R-HSA-416572",
"R-HSA-4420097",
"R-HSA-5627117",
"R-HSA-6798695",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-HSA-9013148",
"R-... | [
"EC:2.7.11",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013406",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013406",
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-3928662",
"REACTOME:R-HSA-3928663",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-416572",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-5627117"... | 63 | [
"2rov",
"7z6e"
] | 2 | [
"PUB00033521",
"PUB00072473",
"PUB00109816",
"PUB00109821",
"PUB00119201",
"PUB00145641",
"PUB00146684",
"PUB00146687",
"PUB00160163"
] | [
"9418861",
"19131646",
"11283607",
"15723050",
"17158456",
"9092543",
"10652353",
"18573880",
"36854301"
] | [
"Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.",
"ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.",
"Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membra... | [
1998,
2009,
2001,
2005,
2007,
1997,
2000,
2008,
2023
] | 9 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
11037
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
77,
7,
23,
22,
32
] | 6 | true | Domain | MRCK/ROCK kinase, PH domain | MRCK/ROCK kinase, PH domain | MRCK/ROCK_PH | 2 |
IPR057530 | 57,530 | MTC6, partial TIM-barrel domain | TIM-barrel_MTC6 | Domain | 795 | false | false | This domain is found in the Maintenance of telomere capping protein 6 (MTC6) from Saccharomyces cerevisiae and related fungal proteins. MTC6 may be involved in telomere capping. The domain represented by this entry is predicted to fold into a partial TIM-barrel. It shares detectable similarity with the Phosphatidylinos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25506"
] | [
"TIM-barrel_MTC6"
] | [
795
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
795
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | MTC6, partial TIM-barrel domain | MTC6, partial TIM-barrel domain | TIM-barrel_MTC6 | 8 |
IPR057531 | 57,531 | PUMA/OVT1, coiled-coil region | PUMA/OVT1_CC | Domain | 558 | false | false | This entry represents a coiled-coil region found in PUMA from Parascaris univalens, Major antigen from Onchocerca volvulus (OVT1) and similar sequences mainly found in animals and some plant species. PUMA may play a role in the organisation of the spindle apparatus and its interaction with the centromeres [ ]. OVT1 may... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24627"
] | [
"PUMA_CC"
] | [
558
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160414",
"PUB00160417"
] | [
"2194123",
"9472001"
] | [
"Characterization of a myosin-like antigen from Onchocerca volvulus.",
"PUMA1: a novel protein that associates with the centrosomes, spindle and centromeres in the nematode Parascaris."
] | [
1990,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Cytophagales",
"Eukaryota",
"Haloferax chudinovii"
] | [
2,
555,
1
] | 3 | [
"Caenorhabditis elegans"
] | [
6
] | 1 | true | Domain | PUMA/OVT1, coiled-coil region | PUMA/OVT1, coiled-coil region | PUMA/OVT1_CC | 5 |
IPR057533 | 57,533 | Plexin-B, PSI domain | PSI_Plexin-B | Domain | 4,457 | false | false | This entry represents a PSI domain found in Plexin B proteins. These are SEMA4 and SEMA5 receptors that play a role in axon guidance, invasive growth and cell migration [ , ]. They play important roles in cell-cell signalling, glutamatergic (Plexin-B2) and GABAergic (Plexin-B1) synapse development and RHOA activation a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24317"
] | [
"PSI_Plexin-B"
] | [
4457
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-416482",
"R-HSA-416550",
"R-HSA-416572",
"R-HSA-416700",
"R-HSA-9013405",
"R-MMU-416482",
"R-MMU-416550",
"R-MMU-416572",
"R-MMU-416700",
"R-MMU-9013405",
"R-RNO-416700"
] | [
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-416550",
"REACTOME:R-HSA-416572",
"REACTOME:R-HSA-416700",
"REACTOME:R-HSA-9013405",
"REACTOME:R-MMU-416482",
"REACTOME:R-MMU-416550",
"REACTOME:R-MMU-416572",
"REACTOME:R-MMU-416700",
"REACTOME:R-MMU-9013405",
"REACTOME:R-RNO-416700"
] | 11 | [] | 0 | [
"PUB00035197",
"PUB00061306",
"PUB00155813",
"PUB00155814"
] | [
"12198496",
"21706053",
"15210733",
"12196628"
] | [
"The semaphorin 4D receptor controls invasive growth by coupling with Met.",
"Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.",
"Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.",
"The semaphorin rec... | [
2002,
2012,
2004,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4457
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
7,
6,
9
] | 4 | true | Domain | Plexin-B, PSI domain | Plexin-B, PSI domain | PSI_Plexin-B | 2 |
IPR057536 | 57,536 | APX 1, N-terminal C2 domain | C2_N_APX | Domain | 36 | false | false | This entry represents the N-terminal C2 domain found in anterior pharynx excess (APX) proteins. C2 domains typically function as calcium-dependent membrane-targeting modules. This specific C2 domain is found at the N-terminal of APX1 from Caenorhabditis elegans, a protein involved in the mediation of Notch signalling [... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25337"
] | [
"C2_N_APX"
] | [
36
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001103",
"PUB00099553",
"PUB00160523",
"PUB00160524",
"PUB00160525"
] | [
"8575327",
"14960273",
"10903169",
"29371032",
"7568229"
] | [
"Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.",
"The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.",
"Left-right asymmetry in C. elegans intestin... | [
1995,
2004,
2000,
2018,
1995
] | 5 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
36
] | 1 | [
"Caenorhabditis elegans"
] | [
4
] | 1 | true | Domain | APX 1, N-terminal C2 domain | APX 1, N-terminal C2 domain | C2_N_APX | 8 |
IPR057537 | 57,537 | C2CD3, N-terminal C2 domain | C2_C2CD3_N | Domain | 1,634 | false | false | This entry represents the N-terminal C2 domain found in C2 domain-containing protein 3 (C2CD3), which contain multiple C2 domains. C2CD3 is a component of the centrioles that acts as a positive regulator of centriole elongation [ ] and is required for primary cilium formation [ ]. It promotes assembly of centriolar dis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25339"
] | [
"C2_C2CD3_N"
] | [
1634
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-XTR-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-XTR-5620912"
] | 3 | [] | 0 | [
"PUB00088074",
"PUB00160526"
] | [
"24997988",
"23769972"
] | [
"The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.",
"Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells."
] | [
2014,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1634
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
19,
4,
7
] | 4 | true | Domain | C2CD3, N-terminal C2 domain | C2CD3, N-terminal C2 domain | C2_C2CD3_N | 9 |
IPR057538 | 57,538 | RXYLT1, C-terminal domain | RXYLT1_C | Domain | 1,468 | false | false | This domain is found in human Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1) and related proteins. It has a detectable similarity to domains members of Glycosyl transferase clan GT-B and it is predicted to adopt similar structure. RXYLT1 acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which ca... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24785"
] | [
"RXYLT1_C"
] | [
1468
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.61",
"PWY-7981",
"R-DRE-9939291",
"R-HSA-9939291",
"R-MMU-9939291"
] | [
"EC:2.4.2.61",
"METACYC:PWY-7981",
"REACTOME:R-DRE-9939291",
"REACTOME:R-HSA-9939291",
"REACTOME:R-MMU-9939291"
] | 5 | [] | 0 | [
"PUB00098859",
"PUB00155298",
"PUB00155299"
] | [
"29477842",
"27130732",
"27733679"
] | [
"Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.",
"The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.",
"The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Fun... | [
2018,
2016,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
71,
1359,
37,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
2
] | 4 | true | Domain | RXYLT1, C-terminal domain | RXYLT1, C-terminal domain | RXYLT1_C | 3 |
IPR057540 | 57,540 | Polycomb protein SUZ12-like, zinc finger domain | Znf_SUZ12 | Domain | 4,527 | false | false | This entry represents the C2H2-type zinc finger domain found in several Polycomb group (PcG) proteins mainly from metazoa and plants, including human Polycomb protein SUZ12. SUZ12 is a component of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affect... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23320"
] | [
"Zn_SUZ12"
] | [
4527
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-212300",
"R-DME-2559580",
"R-DME-8943724",
"R-DME-8953750",
"R-DME-9764725",
"R-DRE-212300",
"R-DRE-2559580",
"R-DRE-9764725",
"R-HSA-212300",
"R-HSA-2559580",
"R-HSA-3214841",
"R-HSA-4551638",
"R-HSA-5617472",
"R-HSA-8943724",
"R-HSA-8953750",
"R-HSA-9609690",
"R-HSA-9710421"... | [
"REACTOME:R-DME-212300",
"REACTOME:R-DME-2559580",
"REACTOME:R-DME-8943724",
"REACTOME:R-DME-8953750",
"REACTOME:R-DME-9764725",
"REACTOME:R-DRE-212300",
"REACTOME:R-DRE-2559580",
"REACTOME:R-DRE-9764725",
"REACTOME:R-HSA-212300",
"REACTOME:R-HSA-2559580",
"REACTOME:R-HSA-3214841",
"REACTOME:R... | 28 | [
"5wai",
"5wak",
"6c23",
"6c24",
"6nq3",
"6wkr",
"7at8",
"7kso",
"7ksr",
"7ktp",
"8eqv",
"8fyh",
"8t9g",
"8tas",
"8tb9",
"8vmi",
"8vml",
"8vnv",
"8vnz",
"9c8u",
"9dch"
] | 21 | [
"PUB00102929",
"PUB00102932",
"PUB00145421",
"PUB00145423",
"PUB00145429",
"PUB00145433"
] | [
"18285464",
"31959557",
"29348366",
"29499137",
"17344414",
"28229514"
] | [
"Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.",
"A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.",
"Structures of human PRC2 with its cofactors AEBP2 and JARID2.",
"Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chroma... | [
2008,
2020,
2018,
2018,
2007,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4527
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
19,
5,
1,
3,
6,
4,
3,
19
] | 8 | true | Domain | Polycomb protein SUZ12-like, zinc finger domain | Polycomb protein SUZ12-like, zinc finger domain | Znf_SUZ12 | 5 |
IPR057541 | 57,541 | Phosphofurin acidic cluster sorting protein 1/2, N-terminal C2 domain | PACS1/2_N | Domain | 4,873 | false | false | This entry represents the N-terminal C2 domain found in phosphofurin acidic cluster sorting (PACS) proteins. C2 domains typically function as calcium-dependent membrane-targeting modules. PACS1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25332"
] | [
"C2_PACS_N"
] | [
4873
] | 1 | [
"REACTOME"
] | [
"R-HSA-164940"
] | [
"REACTOME:R-HSA-164940"
] | 1 | [] | 0 | [
"PUB00044415",
"PUB00160527",
"PUB00160528"
] | [
"9695949",
"15692563",
"15692567"
] | [
"PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.",
"Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.",
"PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis."
] | [
1998,
2005,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4873
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
43,
2,
6,
8,
10
] | 6 | true | Domain | Phosphofurin acidic cluster sorting protein 1/2, N-terminal C2 domain | Phosphofurin acidic cluster sorting protein 1/2, N-terminal C2 domain | PACS1/2_N | 3 |
IPR057542 | 57,542 | U1 small nuclear ribonucleoprotein component SNU71, RNA binding domain | SNU71_RBD | Domain | 108 | false | false | This entry represents the RNA binding domain (RBD, also known as RNA recognition motif, RRM) found in U1 small nuclear ribonucleoprotein component SNU71 from yeast, which is a component of the U1 snRNP particle that recognises and binds the 5'-splice site of pre-mRNA [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24825"
] | [
"SNU71_RBD"
] | [
108
] | 1 | [] | [] | [] | 0 | [
"5zwn",
"6g90",
"6n7x",
"7oqc",
"7oqe"
] | 5 | [
"PUB00147912"
] | [
"29995849"
] | [
"Prespliceosome structure provides insights into spliceosome assembly and regulation."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
108
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | U1 small nuclear ribonucleoprotein component SNU71, RNA binding domain | U1 small nuclear ribonucleoprotein component SNU71, RNA binding domain | SNU71_RBD | 6 |
IPR057543 | 57,543 | U1 small nuclear ribonucleoprotein component SNU71, N-terminal | SNU71_N | Domain | 55 | false | false | This entry represents the N-terminal domain of U1 small nuclear ribonucleoprotein component SNU71 from yeast, which is a component of the U1 snRNP particle that recognises and binds the 5'-splice site of pre-mRNA [ ]. This domain is involved in protein cross-linking and binds between Prp42 N-terminal and the Snu56 KH-l... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24826"
] | [
"SNU71_N"
] | [
55
] | 1 | [] | [] | [] | 0 | [
"5zwn",
"6g90",
"6n7p",
"6n7r",
"6n7x",
"7oqc",
"7oqe",
"8w2o"
] | 8 | [
"PUB00147912"
] | [
"29995849"
] | [
"Prespliceosome structure provides insights into spliceosome assembly and regulation."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
55
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | U1 small nuclear ribonucleoprotein component SNU71, N-terminal | U1 small nuclear ribonucleoprotein component SNU71, N-terminal | SNU71_N | 3 |
IPR057544 | 57,544 | Transcription factor spt8, beta-propeller | Beta-prop_SPT8 | Domain | 1,780 | false | false | This entry represents the β-propeller found in Transcription factor SPT8 (SPT8) from fungi. SPT8 is a member of the transcription regulatory histone acetylation (HAT) complex SAGA. SPT8 interacts with TATA-binding protein (TBP) acting as a suppressor of transcription initiation defects caused by promoter insertions of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23798"
] | [
"Beta-prop_SPT8"
] | [
1780
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062949",
"PUB00087619",
"PUB00157159",
"PUB00160529"
] | [
"10026213",
"25216679",
"28918903",
"10864329"
] | [
"Expanded lysine acetylation specificity of Gcn5 in native complexes.",
"Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.",
"SAGA Is a General Cofactor for RNA Polymerase II Transcription.",
"Redundant roles for the TFIID and SAGA complexes in global transcription."
] | [
1999,
2014,
2017,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nostocales"
] | [
1778,
2
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Transcription factor spt8, beta-propeller | Transcription factor spt8, beta-propeller | Beta-prop_SPT8 | 7 |
IPR057545 | 57,545 | Protein-arginine N-acetylglucosaminyltransferase SseK/NleB | SseK_NleB | Family | 1,745 | false | false | This entry represents the proteobacterial effector proteins SseK and NleB and their homologues. SseK and NleB are bona fide protein-arginine N-acetylglucosaminyltransferases that glycosylate host proteins on arginine residues, leading to reduced NF-kappaB-dependent responses to infection [ , ]. These proteins have diff... | [
"GO:0106362"
] | [
"protein-arginine N-acetylglucosaminyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF24688"
] | [
"SseK_NleB"
] | [
1745
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [
"5h5y",
"5h60",
"5h61",
"5h62",
"5h63",
"5xhp",
"5xyk",
"6aci",
"6ai4",
"6cgi",
"6dus",
"6e66",
"6eyr",
"6eyt",
"7ym5",
"7ym7",
"8px1"
] | 17 | [
"PUB00153054",
"PUB00155850",
"PUB00155851"
] | [
"23955153",
"28522607",
"30327479"
] | [
"Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.",
"NleB/SseK effectors from <i>Citrobacter rodentium</i>, <i>Escherichia coli</i>, and <i>Salmonella enterica</i> display distinct differences in host substrate specificity.",
"Structural basis for arginine glycosylation... | [
2013,
2017,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Glossina pallidipes",
"Pseudomonadota"
] | [
1,
1744
] | 2 | [] | [] | 0 | true | Family | Protein-arginine N-acetylglucosaminyltransferase SseK/NleB | Protein-arginine N-acetylglucosaminyltransferase SseK/NleB | SseK_NleB | 6 |
IPR057546 | 57,546 | Stalled ribosome sensor GCN1-like, HEAT repeats region | HEAT_GCN1 | Domain | 13,635 | false | false | This region of HEAT repeats is found in human Stalled ribosome sensor GCN1 and similar eukaryotic proteins. GCN1 is a ribosome collision sensor that plays a key role in the RNF14 -RNF25 translation quality control pathway, which occurs when a ribosome has stalled during translation, promoting ubiquitination and degrada... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23271"
] | [
"HEAT_GCN1"
] | [
13635
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-1257604",
"R-DDI-1632852",
"R-DDI-165159",
"R-DDI-166208",
"R-DDI-3371571",
"R-DDI-380972",
"R-DDI-389357",
"R-DDI-5218920",
"R-DDI-5628897",
"R-DDI-6804757",
"R-DDI-8943724",
"R-DDI-9639288",
"R-DDI-9856530",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-2565942",
... | [
"REACTOME:R-DDI-1257604",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-165159",
"REACTOME:R-DDI-166208",
"REACTOME:R-DDI-3371571",
"REACTOME:R-DDI-380972",
"REACTOME:R-DDI-389357",
"REACTOME:R-DDI-5218920",
"REACTOME:R-DDI-5628897",
"REACTOME:R-DDI-6804757",
"REACTOME:R-DDI-8943724",
"REACTOME:R-... | 59 | [
"8i9x",
"8i9y",
"8i9z",
"8ia0",
"8onz",
"8pv1",
"8pv2",
"8pv3",
"8pv4",
"8pv5",
"8pv6",
"8pv7",
"8pv8",
"8pvk",
"8pvl",
"8whh",
"8whi",
"8whj",
"8whk",
"8whl"
] | 20 | [
"PUB00155654",
"PUB00155655"
] | [
"32610081",
"36638793"
] | [
"Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate.",
"An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes."
] | [
2020,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Legionella"
] | [
13631,
4
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
74,
1,
25,
34,
2,
11,
36,
1,
1,
22
] | 12 | true | Domain | Stalled ribosome sensor GCN1-like, HEAT repeats region | Stalled ribosome sensor GCN1-like, HEAT repeats region | HEAT_GCN1 | 5 |
IPR057547 | 57,547 | Terminal repeat-encoded protein TreK-like, staphylococcus phage | Phage_TreK-like | Family | 53 | false | false | This entry represents terminal repeat-encoded proteins (TreK) found in Twort-like Staphylococcus phages. Twort-like viruses are members of the Myoviridae family and are characterised by large genomes (>125 kb) with a low G+C content (30-31%) and terminally redundant ends. These terminal repeats are several thousand bas... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24229"
] | [
"Phage_TreK"
] | [
53
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Pseudomonadota",
"marine sediment metagenome"
] | [
48,
4,
1
] | 3 | [] | [] | 0 | true | Family | Terminal repeat-encoded protein TreK-like, staphylococcus phage | Terminal repeat-encoded protein TreK-like, staphylococcus phage | Phage_TreK-like | 2 |
IPR057548 | 57,548 | S-Adenosylmethionine lyase-like | S-AdoMet_lyase-like | Family | 357 | false | false | This entry represents S-Adenosylmethionine lyases ( ) and related proteins. S-Adenosylmethionine lyase catalyses the hydrolysis of S-adenosyl-L-methionine, cleaving it to form L-homoserine and methylthioadenosine. This enzyme is produced by Bacteriophage T3, which infects Escherichia coli cells. SAM hydrolase can remov... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23780"
] | [
"S-AdoMet_lyase"
] | [
357
] | 1 | [] | [] | [] | 0 | [
"7ock",
"8bb1"
] | 2 | [
"PUB00042741",
"PUB00042742",
"PUB00101354",
"PUB00101355"
] | [
"16622061",
"16788729",
"34340545",
"33567250"
] | [
"In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli.",
"In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose.",
"SAMase of Bacteriophage T3 Inactivates Escherichia coli's Methionine <i>S</i>-Adenosyltransferase by Forming He... | [
2006,
2006,
2021,
2021
] | 4 | [] | [
"IPR016290"
] | 0 | 1 | 0 | [
"Bacteria",
"Bdelloidea",
"Viruses",
"metagenomes"
] | [
13,
43,
294,
7
] | 4 | [] | [] | 0 | true | Family | S-Adenosylmethionine lyase-like | S-Adenosylmethionine lyase-like | S-AdoMet_lyase-like | 5 |
IPR057549 | 57,549 | Straight fiber protein PB4, spike domain | PB4_spike | Domain | 288 | false | false | This entry represents the Straight fiber protein PB4 spike found in Escherichia phage T5 and other tailed bacteriophages and some bacterial prophages. The T5 PB4 spike forms a hetero trimer containing several small distinct subdomains some of which defining a β-helix, others are β-prism [ ]. PB4 along with PB3, forms t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24168"
] | [
"PB4_spike"
] | [
288
] | 1 | [] | [] | [] | 0 | [
"7zlv",
"7zn2",
"7zn4",
"7zqb",
"8hre"
] | 5 | [
"PUB00155631"
] | [
"36961893"
] | [
"Structural basis of bacteriophage T5 infection trigger and <i>E. coli</i> cell wall perforation."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"marine sediment metagenome"
] | [
54,
233,
1
] | 3 | [] | [] | 0 | true | Domain | Straight fiber protein PB4, spike domain | Straight fiber protein PB4, spike domain | PB4_spike | 5 |
IPR057550 | 57,550 | Straight fiber protein PB4, first Fn3-like domain | Fn3-I_PB4 | Domain | 228 | false | false | This entry represents the N-terminal Fn3-like domain of the Straight fiber protein PB4 found in in Escherichia phage T5 and other tailed bacteriophages. PB4 along with PB3, forms the central straight fibre, bearing the receptor binding protein PB5 at its C terminus [ ]. Upon PB5 binding to the host receptor FhuA, the c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24169"
] | [
"Fn3-I_PB4"
] | [
228
] | 1 | [] | [] | [] | 0 | [
"7zlv",
"7zn2",
"7zn4",
"7zqb",
"8hre"
] | 5 | [
"PUB00155631"
] | [
"36961893"
] | [
"Structural basis of bacteriophage T5 infection trigger and <i>E. coli</i> cell wall perforation."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
228
] | 1 | [] | [] | 0 | true | Domain | Straight fiber protein PB4, first Fn3-like domain | Straight fiber protein PB4, first Fn3-like domain | Fn3-I_PB4 | 5 |
IPR057551 | 57,551 | Straight fiber protein PB4, second Fn3-like domain | Fn3-II_PB4 | Domain | 230 | false | false | This entry represents the second Fn3-like domain of the Straight fiber protein PB4 found in in Escherichia phage T5 and other tailed bacteriophages. PB4 along with PB3, forms the central straight fibre, bearing the receptor binding protein PB5 at its C terminus [ ]. Upon PB5 binding to the host receptor FhuA, the centr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24170"
] | [
"Fn3-II_PB4"
] | [
230
] | 1 | [] | [] | [] | 0 | [
"7zlv",
"7zn2",
"7zn4",
"7zqb",
"8hre"
] | 5 | [
"PUB00155631"
] | [
"36961893"
] | [
"Structural basis of bacteriophage T5 infection trigger and <i>E. coli</i> cell wall perforation."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Salmonella anatum",
"Viruses"
] | [
1,
229
] | 2 | [] | [] | 0 | true | Domain | Straight fiber protein PB4, second Fn3-like domain | Straight fiber protein PB4, second Fn3-like domain | Fn3-II_PB4 | 1 |
IPR057552 | 57,552 | Straight fiber protein PB4, third Fn3-like domain | Fn3-III_PB4 | Domain | 230 | false | false | This entry represents the third Fn3-like domain of the Straight fiber protein PB4 found in in Escherichia phage T5 and other tailed bacteriophages. PB4 along with PB3, forms the central straight fibre, bearing the receptor binding protein PB5 at its C terminus [ ]. Upon PB5 binding to the host receptor FhuA, the centra... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24171"
] | [
"Fn3-III_PB4"
] | [
230
] | 1 | [] | [] | [] | 0 | [
"7zlv",
"7zn2",
"7zn4",
"7zqb",
"8hre"
] | 5 | [
"PUB00155631"
] | [
"36961893"
] | [
"Structural basis of bacteriophage T5 infection trigger and <i>E. coli</i> cell wall perforation."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Salmonella anatum",
"Viruses"
] | [
1,
229
] | 2 | [] | [] | 0 | true | Domain | Straight fiber protein PB4, third Fn3-like domain | Straight fiber protein PB4, third Fn3-like domain | Fn3-III_PB4 | 3 |
IPR057553 | 57,553 | SAC9, second GBDL domain | SAC9_GBDL_2nd | Domain | 839 | false | false | This domain is found toward the C-terminal of the SAC9 from Arabidopsis thaliana. It is the second of the three GBDL domains. It is predicted to contain a large insertion (~40 residues long) before the last β-strand. SAC9 is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24789"
] | [
"SAC9_GBDL_2nd"
] | [
839
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155832",
"PUB00160530"
] | [
"15923324",
"36044021"
] | [
"Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.",
"The <i>Arabidopsis</i> SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P<sub>2</sub> at the plasma ... | [
2005,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
839
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
14
] | 3 | true | Domain | SAC9, second GBDL domain | SAC9, second GBDL domain | SAC9_GBDL_2nd | 4 |
IPR057554 | 57,554 | SAC9, C-terminal domain | SAC9_C | Domain | 767 | false | false | This domain is found at the C-terminal of SAC9 from Arabidopsis thaliana. It is predicted to fold into a β-sandwich with a similarity to the anaphase promoting complex subunit 10. SAC9 is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals during the stress response [ ]. SAC9... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24765"
] | [
"SAC9_C"
] | [
767
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155832",
"PUB00160530"
] | [
"15923324",
"36044021"
] | [
"Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.",
"The <i>Arabidopsis</i> SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P<sub>2</sub> at the plasma ... | [
2005,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
767
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
9
] | 3 | true | Domain | SAC9, C-terminal domain | SAC9, C-terminal domain | SAC9_C | 3 |
IPR057555 | 57,555 | SAC9, first GBDL domain | SAC9_GBDL_1st | Domain | 822 | false | false | This domain is found toward the C terminus of the SAC9 from Arabidopsis thaliana. It is the first of the three GBDL domains. SAC9 is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals during the stress response [ ]. SAC9 is critical for regulating lipid signaling and endocyt... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24790"
] | [
"SAC9_GBDL_1st"
] | [
822
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155832",
"PUB00160530"
] | [
"15923324",
"36044021"
] | [
"Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.",
"The <i>Arabidopsis</i> SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P<sub>2</sub> at the plasma ... | [
2005,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
822
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
18
] | 3 | true | Domain | SAC9, first GBDL domain | SAC9, first GBDL domain | SAC9_GBDL_1st | 1 |
IPR057556 | 57,556 | Surface lipoprotein assembly modifier, N-terminal TPR repeats region | TPR_Slam | Domain | 1,549 | false | false | This is a region of tetratricopeptide repeats (TPR) found at the N-terminal of Surface lipoprotein assembly modifier from the proteobacteria Pasteurella multocida (Slam) and similar sequences. Slam plays a role in the export to the cell surface of some cell outer membrane lipoproteins [ ]. This domain is usually found ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24575"
] | [
"TPR_Slam"
] | [
1549
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095100"
] | [
"28620585"
] | [
"Identification of a Large Family of Slam-Dependent Surface Lipoproteins in Gram-Negative Bacteria."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Chaetothyriales",
"metagenomes"
] | [
1543,
2,
4
] | 3 | [] | [] | 0 | true | Domain | Surface lipoprotein assembly modifier, N-terminal TPR repeats region | Surface lipoprotein assembly modifier, N-terminal TPR repeats region | TPR_Slam | 9 |
IPR057557 | 57,557 | SAC9, C8D domain | SAC9_C8D | Domain | 688 | false | false | This domain is found in the SAC9 protein from Arabidopsis thaliana. It contains four pairs of highly conserved cysteine residues that are probably involved in metal coordination. SAC9 is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals during the stress response [ ]. SAC9 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24791"
] | [
"SAC9_C8D"
] | [
688
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155832",
"PUB00160530"
] | [
"15923324",
"36044021"
] | [
"Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.",
"The <i>Arabidopsis</i> SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P<sub>2</sub> at the plasma ... | [
2005,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Tracheophyta"
] | [
688
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
17
] | 3 | true | Domain | SAC9, C8D domain | SAC9, C8D domain | SAC9_C8D | 9 |
IPR057558 | 57,558 | SWR1-complex protein 3 domain | Swc3_dom | Domain | 1,206 | false | false | This domain sis found in SWR1-complex protein 3 from Saccharomyces cerevisiae (Swc3) and similar proteins from ascomycetes. Swc3 is a component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remod... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24707"
] | [
"Swc3"
] | [
1206
] | 1 | [] | [] | [] | 0 | [
"9b1e"
] | 1 | [
"PUB00018537",
"PUB00046116"
] | [
"14645854",
"14690608"
] | [
"ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.",
"A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1."
] | [
2004,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1206
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | SWR1-complex protein 3 domain | SWR1-complex protein 3 domain | Swc3_dom | 2 |
IPR057560 | 57,560 | SCAN domain-containing protein 3-like, zinc finger | Znf_SCAND3 | Domain | 475 | false | false | This zinc finger domain is found in human SCAN domain-containing protein 3 (SCAND3) and similar animal proteins. SCAND3 is a candidate prognostic marker for non-small cell lung cancer [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23663"
] | [
"Znf_SCAND3"
] | [
475
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160531"
] | [
"28418919"
] | [
"ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
475
] | 1 | [
"Homo sapiens"
] | [
6
] | 1 | true | Domain | SCAN domain-containing protein 3-like, zinc finger | SCAN domain-containing protein 3-like, zinc finger | Znf_SCAND3 | 6 |
IPR057561 | 57,561 | NAD glycohydrolase, translocation F5/8 type C domain | NADase_transloc | Domain | 2,214 | false | false | This entry represents the N-terminal translocation domain of NAD+-glycohydrolase from Streptococcus pyogenes ( ) that is required for secretion through the SLO pore. The domain spans residues 38-190 and adopts a jelly roll fold with structural similarity to carbohydrate binding modules (CBMs) [ ]. However, it is found ... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047619",
"PF25302"
] | [
"NADase_discoid",
"NADase_transloc"
] | [
2190,
1431
] | 2 | [] | [] | [] | 0 | [
"7ji1"
] | 1 | [
"PUB00159264"
] | [
"34694903"
] | [
"Structure of the Streptococcus pyogenes NAD<sup>+</sup> Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Mus musculus",
"metagenomes"
] | [
2195,
1,
18
] | 3 | [
"Mus musculus"
] | [
1
] | 1 | true | Domain | NAD glycohydrolase, translocation F5/8 type C domain | NAD glycohydrolase, translocation F5/8 type C domain | NADase_transloc | 3 |
IPR057562 | 57,562 | Tli3-like domain | Tli3-like_dom | Domain | 543 | false | false | This entry represents a domain found in the type VI secretion system (T6SS) Tli3 immunity protein from adherent-invasive Escherichia coli and related proteobacterial proteins. Some members have a lipoprotein lipid attachment site. Tli3 is an outer membrane lipoprotein and a cognate immunity protein of T6SS Tle3 phospho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24316"
] | [
"Tli3"
] | [
543
] | 1 | [] | [] | [] | 0 | [
"8boz"
] | 1 | [
"PUB00155864"
] | [
"36675258"
] | [
"Activity and Crystal Structure of the Adherent-Invasive <i>Escherichia coli</i> Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Ralstonia phage RSY1"
] | [
541,
2
] | 2 | [] | [] | 0 | true | Domain | Tli3-like domain | Tli3-like domain | Tli3-like_dom | 3 |
IPR057564 | 57,564 | Serine/threonine-protein kinase ATR-like, HEAT repeats | HEAT_ATR | Domain | 9,698 | false | false | This region of HEAT repeats is found towards the C-terminal of the FAT domain in human Serine/threonine-protein kinase ATR and similar eukaryotic proteins. ATR acts as a DNA damage sensor and is associated with severe disorders such as Seckel syndrome 1. This protein is organised into a large N-terminal α-solenoid cont... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23593"
] | [
"HEAT_ATR"
] | [
9698
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-CEL-1257604",
"R-CEL-1632852",
"R-CEL-165159",
"R-CEL-166208",
"R-CEL-3371571",
"R-CEL-380972",
"R-CEL-389357",
"R-CEL-5218920",
"R-CEL-5628897",
"R-CEL-5693607",
"R-CEL-6804757",
"R-CEL-8943724",
"R-CEL-9639288",
"R-CEL-9856530",
"R-DDI-1257604",
"R-DDI-1632852",
"R... | [
"EC:2.7.11.1",
"REACTOME:R-CEL-1257604",
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-165159",
"REACTOME:R-CEL-166208",
"REACTOME:R-CEL-3371571",
"REACTOME:R-CEL-380972",
"REACTOME:R-CEL-389357",
"REACTOME:R-CEL-5218920",
"REACTOME:R-CEL-5628897",
"REACTOME:R-CEL-5693607",
"REACTOME:R-CEL-6804757... | 122 | [
"3jbz",
"4jsn",
"4jsp",
"4jsv",
"4jsx",
"4jt5",
"4jt6",
"5flc",
"5fvm",
"5h64",
"5wbu",
"5wby",
"5x6o",
"5yz0",
"5zcs",
"6bcu",
"6bcx",
"6emk",
"6sb0",
"6sb2",
"6z2w",
"6z2x",
"6z3a",
"6zwm",
"6zwo",
"7owg",
"7pe7",
"7pe8",
"7pe9",
"7pea",
"7peb",
"7pec"... | 55 | [
"PUB00101556",
"PUB00103870",
"PUB00155647",
"PUB00155648",
"PUB00155649",
"PUB00155650",
"PUB00155651",
"PUB00155652",
"PUB00155653"
] | [
"23636326",
"27909983",
"29271416",
"29191911",
"33169019",
"27097373",
"26678875",
"27072897",
"12640452"
] | [
"mTOR kinase structure, mechanism and regulation.",
"4.4 A Resolution Cryo-EM structure of human mTOR Complex 1.",
"Cryo-EM structure of human ATR-ATRIP complex.",
"3.9 A structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP.",
"Mechanism of auto-inhibition and activation of Mec1<sup>ATR</s... | [
2013,
2016,
2018,
2017,
2021,
2016,
2016,
2016,
2003
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9698
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
3,
3,
7,
7,
4,
2,
6,
8,
3,
3,
27
] | 12 | true | Domain | Serine/threonine-protein kinase ATR-like, HEAT repeats | Serine/threonine-protein kinase ATR-like, HEAT repeats | HEAT_ATR | 1 |
IPR057565 | 57,565 | Transcription elongation regulator 1-like, third WW domain | WW_TCRG1_3rd | Domain | 3,002 | false | false | This entry corresponds to the third WW domain of human Transcription Elongation Regulator 1 (TCRG1) and similar animal proteins. The WW domains within these proteins are responsible for binding to Pro-rich domains, facilitating further protein-protein interactions. TCRG1 (also known as CA150) contains three N-terminal ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23517"
] | [
"WW_TCERG1"
] | [
3002
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163"
] | 2 | [
"2dk7",
"7abf",
"7abg",
"8q7n",
"8qo9"
] | 5 | [
"PUB00098134",
"PUB00098135",
"PUB00160532"
] | [
"11604498",
"16782886",
"9315662"
] | [
"The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.",
"Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regi... | [
2001,
2006,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3002
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4,
6,
5,
11
] | 6 | true | Domain | Transcription elongation regulator 1-like, third WW domain | Transcription elongation regulator 1-like, third WW domain | WW_TCRG1_3rd | 8 |
IPR057566 | 57,566 | TTI1, N-terminal TPR domain | TPR_TTI1_N | Domain | 4,071 | false | false | This entry represents the TPR domain found at the N-terminal of TELO2-interacting protein 1 homologue (TTI1) from animals and yeast. This domain interacts with the FAT domain of the PIKK ATM [ ]. TTI1 binds to TELO2 and TTI2 proteins to form the TTT complex, which plays a role in the assembly and stability of all phosp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24173"
] | [
"TPR_TTI1_N"
] | [
4071
] | 1 | [] | [] | [] | 0 | [
"7f4u",
"7ole"
] | 2 | [
"PUB00054175",
"PUB00073582",
"PUB00155882",
"PUB00155883"
] | [
"19040720",
"20810650",
"25460276",
"34838521"
] | [
"Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.",
"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.",
"PIKKs--the solenoid nest where partners and kinases meet.",
"Structure of the Human T... | [
2008,
2010,
2014,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4071
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
7,
1,
2,
2,
2,
1,
3,
2,
1,
1,
21
] | 11 | true | Domain | TTI1, N-terminal TPR domain | TTI1, N-terminal TPR domain | TPR_TTI1_N | 4 |
IPR057567 | 57,567 | TTI1, C-terminal TPR domain | TPR_TTI1_C | Domain | 4,060 | false | false | This entry represents the TPR domain found at the C-terminal of TELO2-interacting protein 1 homologue (TTI1) from animals and yeast. This domain binds to HEAT repeats of the ATM PIKK [ ]. TTI1 binds to TELO2 and TTI2 proteins to form the TTT complex, which plays a role in the assembly and stability of all phosphatidyli... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24181"
] | [
"TPR_TTI1_C"
] | [
4060
] | 1 | [] | [] | [] | 0 | [
"7f4u",
"7ole"
] | 2 | [
"PUB00054175",
"PUB00073582",
"PUB00155882",
"PUB00155883"
] | [
"19040720",
"20810650",
"25460276",
"34838521"
] | [
"Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.",
"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.",
"PIKKs--the solenoid nest where partners and kinases meet.",
"Structure of the Human T... | [
2008,
2010,
2014,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4060
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizo... | [
7,
1,
1,
2,
2,
1,
1,
2,
1,
1,
3
] | 11 | true | Domain | TTI1, C-terminal TPR domain | TTI1, C-terminal TPR domain | TPR_TTI1_C | 1 |
IPR057569 | 57,569 | C2 domain, nematode | C2_nem | Domain | 472 | false | false | This entry represents a specific C2 domain found in uncharacterised nematode proteins, including C05B5.4 and R10E12.2 from Caenorhabditis elegans. C2 domains are protein modules that can bind calcium and phospholipids. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25330"
] | [
"C2_nem"
] | [
472
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
472
] | 1 | [
"Caenorhabditis elegans"
] | [
4
] | 1 | true | Domain | C2 domain, nematode | C2 domain, nematode | C2_nem | 5 |
IPR057570 | 57,570 | NOL9, C-terminal domain | NOL9_C | Domain | 2,348 | false | false | This domain is found at the C-terminal end of human Polynucleotide 5'-hydroxyl-kinase NOL9 and similar proteins from eukaryotes. This domain is predicted to adopt an α-β configuration. NOL9 and its orthologue Gre3 are polynucleotide 5'-kinases involved in rRNA processing [ , ]. NOL9 can phosphorylate single-stranded an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25467"
] | [
"NOL9_C"
] | [
2348
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1",
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:2.7.1",
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 6 | [
"9dun"
] | 1 | [
"PUB00098073",
"PUB00098074",
"PUB00160535"
] | [
"20814424",
"21063389",
"31288032"
] | [
"Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I.",
"Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing.",
"Nol9 Is a Spatial Regulator for the Human ITS2 Pre-rRNA Endonuclease-Kinase Complex."
] | [
2010,
2010,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2348
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
2,
1,
1,
1,
6,
3,
6
] | 9 | true | Domain | NOL9, C-terminal domain | NOL9, C-terminal domain | NOL9_C | 7 |
IPR057571 | 57,571 | SDR PhqE-like | SDR_PhqE-like | Family | 2,280 | false | false | Short-chain dehydrogenase/reductase (SDR) MalC and PhqE (its homologue from the paraherquamide pathway) are bifunctional enzymes that function as both a reductase and an intramolecular [4+2] Diels-Alderase in the paraherquamide biosynthetic pathway. MalC and PhqE contain a classical SDR fold with a nucleotide-binding s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23441"
] | [
"SDR"
] | [
2280
] | 1 | [] | [] | [] | 0 | [
"6nkh",
"6nkk",
"6nkm"
] | 3 | [
"PUB00022926",
"PUB00023818",
"PUB00024129",
"PUB00024464",
"PUB00036560",
"PUB00155834",
"PUB00160536"
] | [
"9560196",
"10595560",
"10201369",
"11373620",
"8805511",
"23200746",
"31548667"
] | [
"Crystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold.",
"Molecular basis for triclosan activity involves a flipping loop in the active site.",
"Molecular basis of triclosan activity.",
"Pteridine reductase mechanism correlates pterin metabolism with ... | [
1998,
1999,
1999,
2001,
1996,
2013,
2019
] | 7 | [
"IPR051122"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
95,
2185
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | SDR PhqE-like | SDR PhqE-like | SDR_PhqE-like | 4 |
IPR057572 | 57,572 | Non-GDSL lipase-like | NonGDSL | Family | 1,064 | false | false | This entry represents a family of α/β hydrolase enzymes. These presumed enzymes are most similar to the GDSL lipases. However the GDSL motif has been lost suggesting they may have lost their lipase activity. Members are mainly found in proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25182"
] | [
"NonGDSL"
] | [
1064
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"mine drainage metagenome"
] | [
1061,
3
] | 2 | [] | [] | 0 | true | Family | Non-GDSL lipase-like | Non-GDSL lipase-like | NonGDSL | 4 |
IPR057573 | 57,573 | NOL9, N-terminal domain | NOL9_N | Domain | 1,190 | false | false | This domain is found toward the N-terminal end of human Polynucleotide 5'-hydroxyl-kinase NOL9 and similar eukaryotic sequences. This domain is predicted to adopt a cupin fold. NOL9 and its orthologue Gre3 are polynucleotide 5'-kinases involved in rRNA processing [ , ]. NOL9 can phosphorylate single-stranded and double... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24419"
] | [
"Cupin_NOL9"
] | [
1190
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.78",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:2.7.1.78",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 5 | [
"9dun"
] | 1 | [
"PUB00098073",
"PUB00098074",
"PUB00160535"
] | [
"20814424",
"21063389",
"31288032"
] | [
"Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I.",
"Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing.",
"Nol9 Is a Spatial Regulator for the Human ITS2 Pre-rRNA Endonuclease-Kinase Complex."
] | [
2010,
2010,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1190
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
2,
2
] | 5 | true | Domain | NOL9, N-terminal domain | NOL9, N-terminal domain | NOL9_N | 9 |
IPR057574 | 57,574 | Novel STAND NTPase 5 domain | nSTAND_NTPase5_dom | Domain | 867 | false | false | This entry represents a novel domain of the STAND-superfamily of AAA+ ATPases found in prokaryotic conflict systems [ ]. It can be found in association with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25199"
] | [
"nSTAND_NTPase5"
] | [
867
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
76,
779,
4,
8
] | 4 | [] | [] | 0 | true | Domain | Novel STAND NTPase 5 domain | Novel STAND NTPase 5 domain | nSTAND_NTPase5_dom | 5 |
IPR057575 | 57,575 | Novel STAND NTPase 6 domain | nSTAND6_dom | Domain | 40 | false | false | This entry represents a novel domain of the STAND-superfamily of AAA+ ATPases, found in bacterial conflict systems [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25201"
] | [
"nSTAND6"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eumetazoa",
"Methanosarcinaceae"
] | [
34,
3,
3
] | 3 | [] | [] | 0 | true | Domain | Novel STAND NTPase 6 domain | Novel STAND NTPase 6 domain | nSTAND6_dom | 6 |
IPR057576 | 57,576 | NUCB1-like, N-terminal domain | NUCB1_N | Domain | 3,257 | false | false | This domain is found at the N-terminal end of rat Nucb1/2 and similar animal proteins predicted to also have an EF-hand domain. This domain is predicted to adopt an all-α configuration. Nucb2 is a calcium-binding protein that may have a role in calcium homeostasis [ , ]. It can be cleaved into an isoform named nesfatin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25434"
] | [
"NUCB1_N"
] | [
3257
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 6 | [] | 0 | [
"PUB00069356",
"PUB00069357",
"PUB00069360",
"PUB00069361",
"PUB00090762",
"PUB00090765",
"PUB00160537",
"PUB00160538"
] | [
"11749975",
"7811391",
"17036007",
"22293188",
"25038744",
"25907657",
"21653697",
"7890746"
] | [
"Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region.",
"Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein.",
"Identification of nesfatin-1 as a satiety mo... | [
2001,
1994,
2006,
2012,
2014,
2015,
2011,
1995
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3257
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
5,
31,
11,
15
] | 6 | true | Domain | NUCB1-like, N-terminal domain | NUCB1-like, N-terminal domain | NUCB1_N | 6 |
IPR057577 | 57,577 | Nucleoprotein, TPR/MPL1 domain | Nucleoprot-TPR/MLP1_dom | Domain | 4,322 | false | false | This domain is found in human Nucleoprotein TPR and its orthologue in fungi MLP1. This domain is predicted to adopt an α-helical configuration. TPR and MLP1/2 share several features; for example, they have coiled-coil regions and are associated with nuclear pores [ , , ]. TPR is thought to be a component of nuclear por... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25481"
] | [
"Nucleoprot-TPR"
] | [
4322
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-H... | 85 | [] | 0 | [
"PUB00016402",
"PUB00016576",
"PUB00075590",
"PUB00075591"
] | [
"9024684",
"7798308",
"10085285",
"12531921"
] | [
"Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments.",
"Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.",
"Proteins c... | [
1997,
1994,
1999,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactococcus lactis"
] | [
4321,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
4,
4,
4,
8,
1,
3,
3,
1,
1,
26
] | 11 | true | Domain | Nucleoprotein, TPR/MPL1 domain | Nucleoprotein, TPR/MPL1 domain | Nucleoprot-TPR/MLP1_dom | 2 |
IPR057579 | 57,579 | Nucleoside diphosphate kinase 7, DM10 domain | DM10_NDK7 | Domain | 1,467 | false | false | This entry represents the DM10 domain in nucleoside diphosphate kinase 7 (NDK7) proteins. This domain is found preceding either one or two nucleoside diphosphate kinase (NDK) catalytic domains. DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25364"
] | [
"PH_NDK7_N"
] | [
1467
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"3.1.11.-",
"R-BTA-380270",
"R-BTA-380320",
"R-HSA-380270",
"R-HSA-380320",
"R-MMU-380270",
"R-MMU-380320",
"R-RNO-380270",
"R-RNO-380320"
] | [
"EC:2.7.11.1",
"EC:3.1.11.-",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380320",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380320",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380320",
"REACTOME:R-RNO-380270",
"REACTOME:R-RNO-380320"
] | 10 | [
"6u42",
"7rro",
"7ung",
"8g2z",
"8g3d",
"8glv",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8sf7",
"8snb",
"8to0",
"9cpb",
"9cpc",
"9e2g",
"9e5c",
"9e78",
"9fqr"
] | 19 | [
"PUB00043716",
"PUB00087484",
"PUB00097750",
"PUB00103594",
"PUB00160539"
] | [
"16572395",
"21289087",
"30349665",
"36191189",
"24807905"
] | [
"Axonemal protofilament ribbons, DM10 domains, and the link to juvenile myoclonic epilepsy.",
"Functional characterization of putative cilia genes by high-content analysis.",
"EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish.",
"SPACA9 is a lumenal protein of h... | [
2006,
2011,
2018,
2022,
2014
] | 5 | [
"IPR006602"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1467
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
4,
5
] | 4 | true | Domain | Nucleoside diphosphate kinase 7, DM10 domain | Nucleoside diphosphate kinase 7, DM10 domain | DM10_NDK7 | 5 |
IPR057580 | 57,580 | Putative cytidine deaminase, C-terminal domain | Deam_C | Domain | 167 | false | false | This domain is found at the C-terminal end of a group of sequences from proteobacteria. Foldseek predicts high structure similarity of this domain with Cytidine deaminases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24241"
] | [
"Deam_C"
] | [
167
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Peronospora farinosa"
] | [
166,
1
] | 2 | [] | [] | 0 | true | Domain | Putative cytidine deaminase, C-terminal domain | Putative cytidine deaminase, C-terminal domain | Deam_C | 3 |
IPR057581 | 57,581 | Putative phage ssDNA-binding domain | Phage_ssDNA_bind | Domain | 133 | false | false | This entry represents an OB fold domain in a small group of phage proteins that show structural similarity to other phage ssDNA-binding proteins. Structure prediction shows a plausible ssDNA binding pocket on the surface of the domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24083"
] | [
"Phage_ssDNA_bind"
] | [
133
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes"
] | [
33,
100
] | 2 | [] | [] | 0 | true | Domain | Putative phage ssDNA-binding domain | Putative phage ssDNA-binding domain | Phage_ssDNA_bind | 7 |
IPR057582 | 57,582 | Putative phage tail tube protein | Phage_TTP_15 | Family | 81 | false | false | This entry shows structural similarity to the Afp1 tail tube protein from the AFP antifeeding prophage of Serratia. This suggests that this family is also likely to form the inner tail tube. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23971"
] | [
"Phage_TTP_15"
] | [
81
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Salmonella enterica",
"Viruses"
] | [
6,
75
] | 2 | [] | [] | 0 | true | Family | Putative phage tail tube protein | Putative phage tail tube protein | Phage_TTP_15 | 9 |
IPR057584 | 57,584 | RDM3, beta-solenoid | RDM3_C | Domain | 872 | false | false | This entry represents a β-solenoid domain found at the C-terminal region of Protein RNA-directed DNA methylation 3 (RDM3) from Arabidopsis thaliana and similar proteins from plants. This entry also includes putative helicases from bacteria. RNA-directed DNA methylation (RdDM) initiates and re-establishes silencing of t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23348"
] | [
"RDM3_C"
] | [
872
] | 1 | [] | [] | [] | 0 | [
"8hyj"
] | 1 | [
"PUB00155825"
] | [
"31274236"
] | [
"Crosstalk between epigenetic silencing and infection by tobacco rattle virus in Arabidopsis."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
738,
134
] | 2 | [
"Arabidopsis thaliana"
] | [
6
] | 1 | true | Domain | RDM3, beta-solenoid | RDM3, beta-solenoid | RDM3_C | 6 |
IPR057585 | 57,585 | Tetratricopeptide repeat domain, fungi | TPR_dom_fungi | Domain | 1,017 | false | false | This region of Tetatricopeptide-like (TPR) repeats is found in a group of uncharacterised fungal proteins. The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins [ , , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes [ ]. The TPR motif consist... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24603"
] | [
"TPR_30"
] | [
1017
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001313",
"PUB00005443",
"PUB00005695",
"PUB00014195",
"PUB00094363",
"PUB00152604"
] | [
"9482716",
"7667876",
"1882418",
"14659697",
"22404999",
"27088764"
] | [
"The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.",
"Tetratrico peptide repeat interactions: to TPR or not to TPR?",
"The TPR snap helix: a novel protein repeat motif from mitosis to transcription.",
"TPR proteins: the versati... | [
1998,
1995,
1991,
2003,
2012,
2016
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1017
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Tetratricopeptide repeat domain, fungi | Tetratricopeptide repeat domain, fungi | TPR_dom_fungi | 2 |
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