interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR057349 | 57,349 | Meiotically up-regulated Mug190 protein, third C2 domain | C2_Mug190_3rd | Domain | 2,273 | false | false | This entry represents the third C2 domain found in the meiotically up-regulated protein Mug190 (MU190) from Schizosaccharomyces pombe ( ). C2 domains typically function as calcium-dependent membrane-targeting modules. This specific C2 domain is found as part of a multi-C2 domain protein that is expressed during meiosis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25331"
] | [
"C2_Mug190_3rd"
] | [
2273
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2273
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1
] | 2 | true | Domain | Meiotically up-regulated Mug190 protein, third C2 domain | Meiotically up-regulated Mug190 protein, third C2 domain | C2_Mug190_3rd | 2 |
IPR057350 | 57,350 | Thrombomodulin-like domain | THBD | Domain | 582 | false | false | This domain is found in human Thrombomodulin (THBD) and similar animal proteins. THBD is an endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. This domain adopts a mainly β configuration. Thi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25444"
] | [
"THBD"
] | [
582
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140875",
"R-HSA-202733",
"R-MMU-140875",
"R-MMU-202733"
] | [
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-202733",
"REACTOME:R-MMU-140875",
"REACTOME:R-MMU-202733"
] | 4 | [
"7t4r"
] | 1 | [
"PUB00160468",
"PUB00160469"
] | [
"20484976",
"21466550"
] | [
"Endosialin/TEM-1/CD248 regulates pericyte proliferation through PDGF receptor signaling.",
"The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
582
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
3
] | 3 | true | Domain | Thrombomodulin-like domain | Thrombomodulin-like domain | THBD | 7 |
IPR057351 | 57,351 | Transmembrane protein 225 domain | TM225_dom | Domain | 358 | false | false | This domain is found in human Transmembrane protein 225 (TM225), 225B (TM225B) and similar animal proteins. This domain is predicted to adopt an all-α configuration. Transmembrane protein 225 (TM225) is specifically expressed in testis [ ]. It may be involved in the differentiation and function of spermatozoa through t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25452"
] | [
"TM225"
] | [
358
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060082",
"PUB00079053",
"PUB00079054"
] | [
"19389623",
"25605614",
"20979528"
] | [
"Docking motif-guided mapping of the interactome of protein phosphatase-1.",
"TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa.",
"Localization and characterization of rat transmembrane protein 225 specifically expressed in testis."
] | [
2009,
2015,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
358
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2
] | 3 | true | Domain | Transmembrane protein 225 domain | Transmembrane protein 225 domain | TM225_dom | 6 |
IPR057352 | 57,352 | TmcB/TmcC, TPR repeats | TPR_TmcB/C | Domain | 2,476 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found in Tiny macrocysts protein B and C from Dictyostelium discoideum (TmcB and TmcC) and similar eukaryotic proteins. TmcB is a regulator of the cAMP signalling pathway specific to sexual development. It controls the levels of external cAMP by regulating the ex... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25474"
] | [
"TPR_TmcB"
] | [
2476
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160361"
] | [
"15817229"
] | [
"Reverse genetic analyses of gamete-enriched genes revealed a novel regulator of the cAMP signaling pathway in Dictyostelium discoideum."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina siciliae T4/M"
] | [
14,
2461,
1
] | 3 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
2
] | 2 | true | Domain | TmcB/TmcC, TPR repeats | TmcB/TmcC, TPR repeats | TPR_TmcB/C | 1 |
IPR057353 | 57,353 | TNF receptor-like domain | TNFR_nem | Domain | 353 | false | false | This entry represents a TNF receptor-like domain found widely distributed throughout nematodes, including both Chromadorea and Enoplea. The domain appears in multiple copies in transmembrane proteins involved in cell adhesion and matrix interactions, such as MUP-4 and MUA-3 in C. elegans. The domain is found across mul... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25314"
] | [
"TNFR_nem"
] | [
353
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
353
] | 1 | [
"Caenorhabditis elegans"
] | [
2
] | 1 | true | Domain | TNF receptor-like domain | TNF receptor-like domain | TNFR_nem | 1 |
IPR057354 | 57,354 | Toc75-like, POTRA domain | POTRA1_3_Toc75 | Domain | 975 | false | false | This entry represents the first and third POTRA domains of Toc75 from Arabidopsis thaliana and similar plant proteins. The first and third POTRA domains fold into one another, each containing the conserved core β-α-α-β-β fold seen in other POTRA domains [ ]. Toc75 is an essential protein required for the import of prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25282"
] | [
"POTRA1_3_Toc75"
] | [
975
] | 1 | [] | [] | [] | 0 | [
"5uay",
"5ubc",
"8dn6",
"8dn7"
] | 4 | [
"PUB00055273",
"PUB00160164",
"PUB00160165",
"PUB00160166"
] | [
"20348103",
"28559331",
"20351097",
"36977410"
] | [
"Conserved properties of polypeptide transport-associated (POTRA) domains derived from cyanobacterial Omp85.",
"The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts.",
"Omp85 from the thermophilic cyanobacterium Thermosynechococcus elongatus differs from proteobacter... | [
2010,
2017,
2010,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
975
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
8,
19
] | 3 | true | Domain | Toc75-like, POTRA domain | Toc75-like, POTRA domain | POTRA1_3_Toc75 | 9 |
IPR057355 | 57,355 | Toc75-like, second POTRA domain | POTRA2_Toc75 | Domain | 937 | false | false | This entry represents the second POTRA domain of Toc75 from Arabidopsis thaliana and similar plant proteins. The second POTRA domain contains a 40-residue insertion that folds into an elongated extra α-helix and loop, producing an overall β-α-α-β-β fold [ ]. Toc75 is an essential protein required for the import of prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25280"
] | [
"POTRA2_Toc75"
] | [
937
] | 1 | [] | [] | [] | 0 | [
"5uay",
"5ubc",
"8dn6",
"8dn7"
] | 4 | [
"PUB00160164",
"PUB00160166"
] | [
"28559331",
"36977410"
] | [
"The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts.",
"Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum."
] | [
2017,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
937
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
8,
19
] | 3 | true | Domain | Toc75-like, second POTRA domain | Toc75-like, second POTRA domain | POTRA2_Toc75 | 3 |
IPR057356 | 57,356 | ZNF592-like, C2H2 zinc finger | Znf-C2H2_ZNF592 | Domain | 3,509 | false | false | This C2H2 zinc finger domain is found in a group of zinc-finger proteins such as ZN532, ZN687, ZN592 and related proteins which are probably involved in transcriptional regulation. A missense mutation in ZNF592 was found associated with CAMOS (Cerebellar Ataxia with Mental retardation, Optic atrophy and Skin abnormalit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25412"
] | [
"zf-C2H2_ZNF592"
] | [
3509
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160211"
] | [
"20531441"
] | [
"CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3509
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
38,
7,
8,
10
] | 4 | true | Domain | ZNF592-like, C2H2 zinc finger | ZNF592-like, C2H2 zinc finger | Znf-C2H2_ZNF592 | 9 |
IPR057357 | 57,357 | ZFAND2A/B-like, C2H2 zinc finger | Znf-C2H2_ZFAND2A/B | Domain | 3,996 | false | false | This C2H2 zinc finger is found in the stress-associated proteins AN1-type zinc finger protein 2A and 2B (ZFAND2A and ZFAND2B), and their plant homologues SAP11/13/16. The precise function of these proteins is unknown. The human ZFAND2A/AIRAP was identified as a stress-regulated survival factor implicated in the stabili... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25403"
] | [
"zf-C2H2_ZFAND2"
] | [
3996
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160209"
] | [
"31540997"
] | [
"The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3996
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
2,
4,
1,
12,
5,
3,
7,
3
] | 9 | true | Domain | ZFAND2A/B-like, C2H2 zinc finger | ZFAND2A/B-like, C2H2 zinc finger | Znf-C2H2_ZFAND2A/B | 1 |
IPR057359 | 57,359 | YfjL-like, N-terminal domain | YfjL_N | Domain | 453 | false | false | This entry represents the N-terminal domain of the uncharacterised protein YfjL from Bacillus subtilis and similar sequences from Bacillota. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25425"
] | [
"YfjL_N"
] | [
453
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"bioreactor metagenome"
] | [
450,
3
] | 2 | [] | [] | 0 | true | Domain | YfjL-like, N-terminal domain | YfjL-like, N-terminal domain | YfjL_N | 4 |
IPR057360 | 57,360 | YxzE-like putative bacteriocin | YxzE | Family | 161 | false | false | This entry represents a putative bacteriocin family related to the YxzE protein found in B. subtilis. This entry contains both the leader peptide and the putative bacteriocin sequence. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25184"
] | [
"YxzE"
] | [
161
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160207"
] | [
"16845009"
] | [
"BAGEL: a web-based bacteriocin genome mining tool."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
161
] | 1 | [] | [] | 0 | true | Family | YxzE-like putative bacteriocin | YxzE-like putative bacteriocin | YxzE | 7 |
IPR057361 | 57,361 | WD repeat-containing protein 35, TPR repeats | TPR_WDR35 | Repeat | 2,198 | false | false | This region of tetratricopeptide (TPR)-like repeats is found in human WD repeat-containing protein 35 (WDR35), a component of the IFT complex A (IFT-A), which is involved in ciliogenesis and ciliary protein trafficking. Members of this entry are mainly found in animals. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25170"
] | [
"TPR_WDR35"
] | [
2198
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924",
"R-RNO-5610787",
"R-RNO-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-RNO-5610787",
"REACTOME:R-RNO-5620924"
] | 6 | [
"8bbe",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8ruy"
] | 10 | [
"PUB00155528",
"PUB00158865",
"PUB00160195"
] | [
"36462505",
"36775821",
"36563665"
] | [
"IFT-A structure reveals carriages for membrane protein transport into cilia.",
"Human IFT-A complex structures provide molecular insights into ciliary transport.",
"Mechanism of IFT-A polymerization into trains for ciliary transport."
] | [
2022,
2023,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2198
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
2,
1,
3
] | 6 | true | Repeat | WD repeat-containing protein 35, TPR repeats | WD repeat-containing protein 35, TPR repeats | TPR_WDR35 | 5 |
IPR057362 | 57,362 | WDGH domain | WDGH | Domain | 359 | false | false | This domain is found in uncharacterised proteins from phages and bacteriophages. It is predicted to adopt an unique α/β structure composed of a central mixed four-stranded β-sheet and α-helices packed on one side of it. Members of this entry contain a highly conserved WDGH sequence motif after which it was named. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25311"
] | [
"WDGH"
] | [
359
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"Viruses",
"metagenomes"
] | [
261,
5,
83,
10
] | 4 | [] | [] | 0 | true | Domain | WDGH domain | WDGH domain | WDGH | 7 |
IPR057363 | 57,363 | Volactin | Volactin | Family | 377 | false | false | This entry represents Volactin ( ), an actin homologue that plays a role in disk-shape morphogenesis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25216"
] | [
"Volactin"
] | [
377
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153671"
] | [
"38360755"
] | [
"Identification of structural and regulatory cell-shape determinants in Haloferax volcanii."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
66,
293,
18
] | 3 | [] | [] | 0 | true | Family | Volactin | Volactin | Volactin | 8 |
IPR057365 | 57,365 | Up-regulator of cell proliferation-like domain | URGCP | Domain | 4,142 | false | false | This domain is found in the human URGCP. This domain is also found in human Interferon-induced very large GTPase 1 and caspase recruitment domain-containing protein 6. This domain is predicted to adopt an α-β structure. URGCP, the up-regulator of cell proliferation, may be involved in cell cycle progression through the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25496"
] | [
"URGCP"
] | [
4142
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160385"
] | [
"17217616"
] | [
"Enhanced cell survival of gastric cancer cells by a novel gene URG4."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Cyanophyceae",
"Opisthokonta"
] | [
4,
4138
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
41,
9,
7,
14
] | 4 | true | Domain | Up-regulator of cell proliferation-like domain | Up-regulator of cell proliferation-like domain | URGCP | 4 |
IPR057366 | 57,366 | TRPM-like domain | TRPM-like | Domain | 15,950 | false | false | This domain is found in human transient receptor potential cation channel subfamily M member 1-8 (TRPM 1-8) and similar proteins. This domain is found associated with [ ] and adopts an all-α configuration. This entry also includes protein ced-11 of Caenorhabditis elegans, which plays a major role in programmed cell dea... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25508"
] | [
"TRPM2"
] | [
15950
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-3295583",
"R-DME-3295583",
"R-DRE-3295583",
"R-DRE-6798695",
"R-HSA-3295583",
"R-HSA-6798695",
"R-HSA-9717207",
"R-HSA-9824594",
"R-MMU-3295583",
"R-MMU-6798695",
"R-RNO-3295583",
"R-RNO-6798695"
] | [
"REACTOME:R-CEL-3295583",
"REACTOME:R-DME-3295583",
"REACTOME:R-DRE-3295583",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-3295583",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9717207",
"REACTOME:R-HSA-9824594",
"REACTOME:R-MMU-3295583",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-3295583",
"REACTOM... | 12 | [
"5wp6",
"5zx5",
"6bcj",
"6bcl",
"6bco",
"6bcq",
"6bpq",
"6bqr",
"6bqv",
"6bwd",
"6bwf",
"6bwi",
"6co7",
"6d73",
"6drj",
"6drk",
"6mix",
"6miz",
"6mj2",
"6nr2",
"6nr3",
"6nr4",
"6o6a",
"6o6r",
"6o72",
"6o77",
"6pkv",
"6pkw",
"6pkx",
"6puo",
"6pur",
"6pus"... | 132 | [
"PUB00160196",
"PUB00160197",
"PUB00160198",
"PUB00160199",
"PUB00160200",
"PUB00160201",
"PUB00160452",
"PUB00160453"
] | [
"30108148",
"29211714",
"29217583",
"29217581",
"29463718",
"31513012",
"28760991",
"37402746"
] | [
"Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.",
"Structures of the calcium-activated, non-selective cation channel TRPM4.",
"Structure of the cold- and menthol-sensing ion channel TRPM8.",
"Structure of the human TRPM4 ion channel in a lipid nanodisc.",
"Struc... | [
2018,
2017,
2018,
2018,
2018,
2019,
2017,
2023
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
15950
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
95,
8,
56,
37,
43
] | 6 | true | Domain | TRPM-like domain | TRPM-like domain | TRPM-like | 5 |
IPR057367 | 57,367 | Transmembrane protein PVRIG, immunoglobulin-like domain | Ig_PVRIG | Domain | 239 | false | false | This domain is found towards the N-terminal end of PVRIG and similar animal proteins. The human transmembrane protein (PVRIG) is a cell surface receptor for NECTIN2. It may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals [ ]. It competes with CD226 to bind to CD112 [ ] | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25456"
] | [
"Ig_PVRIG"
] | [
239
] | 1 | [] | [] | [] | 0 | [
"8x6b",
"9e6y"
] | 2 | [
"PUB00083570",
"PUB00160144"
] | [
"26755705",
"38626767"
] | [
"Identification of CD112R as a novel checkpoint for human T cells.",
"Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2."
] | [
2016,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
239
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Domain | Transmembrane protein PVRIG, immunoglobulin-like domain | Transmembrane protein PVRIG, immunoglobulin-like domain | Ig_PVRIG | 7 |
IPR057368 | 57,368 | USP32, N-terminal domain | USP32_N | Domain | 1,834 | false | false | This domain is found at the N-terminal of USP32 and related eukaryotic proteins. The domain represented by this entry has detectable similarity to EF-hand domains, and it is predicted to adopt similar structure. It lacks the Ca2+ coordinating residues. Ubiquitin carboxyl-terminal hydrolase 32 (USP32) functions as a deu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25265"
] | [
"USP32_N"
] | [
1834
] | 1 | [
"EC"
] | [
"3.4.19.12"
] | [
"EC:3.4.19.12"
] | 1 | [] | 0 | [
"PUB00160204",
"PUB00160451"
] | [
"36476874",
"11683918"
] | [
"USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.",
"A deubiquitinating enzyme, UCH/CeUBP130, has an essential role in the formation of a functional microtubule-organizing centre (MTOC) during early cleavage in C. elegans."
] | [
2022,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1834
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
1,
4
] | 5 | true | Domain | USP32, N-terminal domain | USP32, N-terminal domain | USP32_N | 5 |
IPR057369 | 57,369 | VG15 protein | VG15 | Family | 1,584 | false | false | This entry represents the Gene 15 protein (VG15) from Mycobacterium phages D29 and L5 and related proteins from tailed bacteriophages. This family is probably distantly related to [ ] and likely represents phage capsid proteins. Members of this family contain two pairs of highly conserved cysteine residues that may con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25310"
] | [
"VG15"
] | [
1584
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045072"
] | [
"9636706"
] | [
"Genome structure of mycobacteriophage D29: implications for phage evolution."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"freshwater metagenome"
] | [
791,
792,
1
] | 3 | [] | [] | 0 | true | Family | VG15 protein | VG15 protein | VG15 | 1 |
IPR057370 | 57,370 | Endolysin-like domain | ELLD | Domain | 303 | false | false | This domain is found in a group of uncharacterised phage and bacterial proteins. It is related to domains that are members of the NlpC/P60 and Bacteriophage peptidoglycan hydrolase families of papain-like cysteine proteases, [ ] and [ ], respectively. This domain is probably catalytically active as it contains highly c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25309"
] | [
"ELLD"
] | [
303
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"bioreactor metagenome"
] | [
224,
77,
2
] | 3 | [] | [] | 0 | true | Domain | Endolysin-like domain | Endolysin-like domain | ELLD | 1 |
IPR057371 | 57,371 | Vitelline envelope sperm lysin receptor, C-terminal domain | VERL_C | Domain | 424 | false | false | This entry represents the C-terminal domain of VERL and related proteins, which is related to the zona pellucida domain in animals ( ). Members of this group are mainly found in invertebrates. VERL (Vitelline envelope sperm lysin receptor) is a giant unbranched glycoprotein comprising 30% of the vitelline envelope. It ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25272"
] | [
"VERL_C"
] | [
424
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155680"
] | [
"28622512"
] | [
"Structural Basis of Egg Coat-Sperm Recognition at Fertilization."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
424
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Domain | Vitelline envelope sperm lysin receptor, C-terminal domain | Vitelline envelope sperm lysin receptor, C-terminal domain | VERL_C | 9 |
IPR057372 | 57,372 | UBP8/5-like, ubiquitin-like domain | Ubiquitin_UBP8/5 | Domain | 1,637 | false | false | This domain is found in UBP5 and UBP8 from Arabidopsis thaliana and similar plant proteins. This domain is often found associated with [ ]. Ubiquitin carboxyl-terminal hydrolases 5 and 8 (UBP5 and UBP8) recognise and hydrolyse the peptide bond at the C-terminal Gly of ubiquitin ( ) [ ]. In Arabidopsis thaliana, UBP5 is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25242"
] | [
"Ubiquitin_UBP8"
] | [
1637
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160372",
"PUB00160450"
] | [
"10898935",
"30603810"
] | [
"Ubiquitin-specific proteases from Arabidopsis thaliana: cloning of AtUBP5 and analysis of substrate specificity of AtUBP3, AtUBP4, and AtUBP5 using Escherichia coli in vivo and in vitro assays.",
"FLA, which encodes a homolog of UBP, is required for chlorophyll accumulation and development of lemma and palea in ... | [
2000,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Euphyllophyta"
] | [
1637
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
10,
13
] | 3 | true | Domain | UBP8/5-like, ubiquitin-like domain | UBP8/5-like, ubiquitin-like domain | Ubiquitin_UBP8/5 | 5 |
IPR057373 | 57,373 | ZNFX1 domain | ZNFX1 | Domain | 3,932 | false | false | This domain is found in Znfx1 proteins in animals or hrr1 in fission yeast. This domain is often found associated with [ ] and is predicted to adopt a mainly-β configuration. Znfx1, or NFX1-type zinc finger-containing protein 1, are RNA-binding proteins involved in antiviral responses and immunity against certain bacte... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25396"
] | [
"ZNFX1"
] | [
3932
] | 1 | [] | [] | [] | 0 | [
"9q9z"
] | 1 | [
"PUB00100916",
"PUB00160449"
] | [
"31685995",
"33876776"
] | [
"Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.",
"Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease."
] | [
2019,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3932
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
5,
3,
1,
5,
1
] | 6 | true | Domain | ZNFX1 domain | ZNFX1 domain | ZNFX1 | 9 |
IPR057376 | 57,376 | Trematode, PH-like domain | PH_trem | Domain | 451 | false | false | This entry represents an uncharacterised family of PH-like domains found in trematode proteins. Trematodes are a class of flatworms. They are obligate internal parasites with a complex life cycle requiring at least two hosts [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25356"
] | [
"PH_trem"
] | [
451
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160448"
] | [
"33809501"
] | [
"Trematode Proteomics: Recent Advances and Future Directions."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Platyhelminthes"
] | [
451
] | 1 | [] | [] | 0 | true | Domain | Trematode, PH-like domain | Trematode, PH-like domain | PH_trem | 1 |
IPR057377 | 57,377 | Connectase MJ0548-like, C-terminal domain | MJ0548_C | Domain | 92 | false | false | This domain is found at the C-terminal end of Connectase MJ0548 from Methanocaldococcus jannaschii and similar archaeal sequences. This protein is a sequence-specific protein ligase. MJ0548 is a distant, monomeric proteasome homologue which connects proteins in a sequence-specific manner. It shows a mainly β structure ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25274"
] | [
"MJ0548_C"
] | [
92
] | 1 | [] | [] | [] | 0 | [
"6zvz",
"6zw0"
] | 2 | [
"PUB00158988"
] | [
"33688044"
] | [
"Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Methanomada group",
"bioreactor metagenome"
] | [
91,
1
] | 2 | [] | [] | 0 | true | Domain | Connectase MJ0548-like, C-terminal domain | Connectase MJ0548-like, C-terminal domain | MJ0548_C | 4 |
IPR057378 | 57,378 | Pre-tape measure protein | Pre_tape_measure | Family | 126 | false | false | This entry represents a conserved region found in bacteriophage pre-tape measure proteins, located just upstream of the tape measure protein. The region is typically around 140-160 amino acids in length. In some phages, the pre-tape measure protein is produced by a programmed translational frameshift [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23789"
] | [
"Pre_tape_measure"
] | [
126
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094497"
] | [
"23851014"
] | [
"A balanced ratio of proteins from gene G and frameshift-extended gene GT is required for phage lambda tail assembly."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Pseudomonadota",
"marine sediment metagenome"
] | [
74,
50,
2
] | 3 | [] | [] | 0 | true | Family | Pre-tape measure protein | Pre-tape measure protein | Pre_tape_measure | 1 |
IPR057379 | 57,379 | Prospore membrane adapter protein SPO71, PH domain | PH_SPO71 | Domain | 1,155 | false | false | This domain is found in the budding yeast prospore membrane adapter protein SPO71, including its orthologue Mug56 from fission yeasts. The domain represented by this entry has weak sequence similarity to PH domains, and it is predicted to adopt a similar structure. SPO71 is predicted to contain a tandem of three PH dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23207"
] | [
"PH_SPO71"
] | [
1155
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044889",
"PUB00100708",
"PUB00100709"
] | [
"16303567",
"22611022",
"24036347"
] | [
"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.",
"SPO71 mediates prospore membrane size and maturation in Saccharomyces cerevisiae.",
"SPO71 encodes a developmental stage-specific partner for Vps13 in Saccharomyces cerevisiae."
] | [
2005,
2012,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1155
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Prospore membrane adapter protein SPO71, PH domain | Prospore membrane adapter protein SPO71, PH domain | PH_SPO71 | 3 |
IPR057380 | 57,380 | Protein kinase SIK1/2/3, UBA domain | UBA_SIK1/2/3 | Domain | 5,036 | false | false | This domain is found in the human Serine/threonine-protein kinase (salt-inducible kinase) SIK1, SIK2, SIK3 and related proteins, including Sperm motility kinase Y. The domain represented by this entry has a significant sequence similarity to UBA domains, and it is predicted to adopt a similar structure consisting of a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23312"
] | [
"UBA_SIK3"
] | [
5036
] | 1 | [
"EC",
"REACTOME"
] | [
"2.7.11.1",
"R-HSA-9931510"
] | [
"EC:2.7.11.1",
"REACTOME:R-HSA-9931510"
] | 2 | [
"8oku",
"8r4o",
"8r4q",
"8r4u",
"8r4v"
] | 5 | [
"PUB00084097",
"PUB00155901",
"PUB00160403",
"PUB00160447"
] | [
"19622832",
"30232230",
"21084751",
"30150136"
] | [
"SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.",
"The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.",
"Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.",
"Salt... | [
2009,
2018,
2010,
2018
] | 4 | [
"IPR015940"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
5036
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
8,
7,
14,
11
] | 5 | true | Domain | Protein kinase SIK1/2/3, UBA domain | Protein kinase SIK1/2/3, UBA domain | UBA_SIK1/2/3 | 2 |
IPR057381 | 57,381 | Zinc finger, Tenuivirus | Znf_Tenuivirus | Domain | 52 | false | false | This entry represents a zinc finger domain found in proteins from tenuivirus, such as P3, which is a plant virus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25219"
] | [
"Znf_Tenuivirus"
] | [
52
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tenuivirus oryzabrevis"
] | [
52
] | 1 | [] | [] | 0 | true | Domain | Zinc finger, Tenuivirus | Zinc finger, Tenuivirus | Znf_Tenuivirus | 2 |
IPR057382 | 57,382 | Type VI secretion system effector TseH-like | TseH | Domain | 403 | false | false | This domain is found in the Type VI secretion system effector TseH and related bacterial proteins. TseH structure is significantly similar to papain-like proteases, including the conserved active site architecture ( ). This domain is standalone or combined with [ ]. V. cholerae T6SS effector TseH is a PAAR-dependent sp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25218"
] | [
"TseH"
] | [
403
] | 1 | [] | [] | [] | 0 | [
"6v98"
] | 1 | [
"PUB00160202"
] | [
"32094588"
] | [
"Envelope stress responses defend against type six secretion system attacks independently of immunity proteins."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
400,
3
] | 2 | [] | [] | 0 | true | Domain | Type VI secretion system effector TseH-like | Type VI secretion system effector TseH-like | TseH | 7 |
IPR057383 | 57,383 | Type I Thoeris inhibitor Tad3 | Tad3 | Family | 98 | false | false | This entry represents the Tad3 family of phage proteins that inhibit the bacterial Type I Thoeris defence system. Tad3 forms a homodimer that binds two ThsB proteins, blocking their active sites by inserting a conserved serine residue (S48) that forms a hydrogen bond with the ThsB catalytic residue E85. This prevents t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25185"
] | [
"Tad3"
] | [
98
] | 1 | [] | [] | [] | 0 | [
"9b7d"
] | 1 | [
"PUB00160446"
] | [
"39855193"
] | [
"Structure-guided discovery of viral proteins that inhibit host immunity."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
59,
33,
6
] | 3 | [] | [] | 0 | true | Family | Type I Thoeris inhibitor Tad3 | Type I Thoeris inhibitor Tad3 | Tad3 | 8 |
IPR057384 | 57,384 | Myxosortase MrtX | CAAX_MXAN_2755 | Family | 50 | false | false | Members of this family, such as the founding protein (MrtX, MXAN_2755) from Myxococcus xanthus ( ), are restricted to the taxonomic order Myxococcales, within the Deltaproteobacteria. The N-terminal region is a domain unique to this family. The C-terminal domain is a CPBP family (Rce1-like) intramembrane glutamic endop... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF040593"
] | [
"CPBP_fam_MrtX"
] | [
50
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154714",
"PUB00160410"
] | [
"38084967",
"40071993"
] | [
"<i>In silico</i> discovery of the myxosortases that process MYXO-CTERM and three novel prokaryotic C-terminal protein-sorting signals that share invariant Cys residues.",
"Myxosortase: an intramembrane protease that sorts MYXO-CTERM proteins to the cell surface."
] | [
2024,
2025
] | 2 | [] | [] | 0 | 0 | null | [
"Cystobacterineae"
] | [
50
] | 1 | [] | [] | 0 | true | Family | Myxosortase MrtX | Myxosortase MrtX | CAAX_MXAN_2755 | 7 |
IPR057385 | 57,385 | Type I Thoeris inhibitor Tad4-like | Tad4-like | Family | 99 | false | false | This entry represents the Tad4 family of phage proteins that inhibit the bacterial Type I Thoeris defence system. Tad4 binds directly to ThsB and blocks its active site via a conserved loop region, preventing production of the immune signalling molecule gcADPR. Interestingly, Tad4 can also bind and inhibit plant and hu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25186"
] | [
"Tad4"
] | [
99
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00156031"
] | [
"36174646"
] | [
"Viruses inhibit TIR gcADPR signalling to overcome bacterial defence."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
22,
71,
6
] | 3 | [] | [] | 0 | true | Family | Type I Thoeris inhibitor Tad4-like | Type I Thoeris inhibitor Tad4-like | Tad4-like | 2 |
IPR057386 | 57,386 | Type I Thoeris inhibitor Tad6-like | Tad6-like | Family | 37 | false | false | This entry represents the Tad6 family of phage proteins that inhibit the bacterial Type I Thoeris defence system. Like Tad3 and Tad4, Tad6 directly blocks the active site pocket of ThsB via a conserved loop region that interacts with the catalytic residues. Mutation of this loop impairs the anti-Thoeris function. This ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25188"
] | [
"Tad6"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
8,
7,
22
] | 3 | [] | [] | 0 | true | Family | Type I Thoeris inhibitor Tad6-like | Type I Thoeris inhibitor Tad6-like | Tad6-like | 7 |
IPR057387 | 57,387 | Type II Thoeris inhibitor Tad8-like | Tad8-like | Family | 11 | false | false | This entry represents the Tad8 family of phage proteins that inhibit the bacterial Type II Thoeris defence system. Tad8 forms a homodimer that binds to the Macro domain of the ThsA protein, inserting loops that occupy the His-ADPR binding pocket and prevent recognition of the immune signalling molecule. This family als... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25189"
] | [
"Tad8"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Clostridia",
"Viruses"
] | [
3,
8
] | 2 | [] | [] | 0 | true | Family | Type II Thoeris inhibitor Tad8-like | Type II Thoeris inhibitor Tad8-like | Tad8-like | 9 |
IPR057388 | 57,388 | UGP3-like, C-terminal hexapeptide repeats | Hexapep_UGP3_C | Domain | 708 | false | false | This region of hexapeptide repeats is found at the C-terminal end of UTP--glucose-1-phosphate uridylyltransferase 3, chloroplastic from Arabidopsis thaliana (UGP3) and similar plant proteins. UGP3 is involved in the biosynthesis of sulfolipids in the chloroplast. It catalyses the first committed step in sulfolipid bios... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25441"
] | [
"Hexapep_UGP3_C"
] | [
708
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160470"
] | [
"19286968"
] | [
"A chloroplastic UDP-glucose pyrophosphorylase from Arabidopsis is the committed enzyme for the first step of sulfolipid biosynthesis."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viridiplantae"
] | [
16,
692
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
6
] | 3 | true | Domain | UGP3-like, C-terminal hexapeptide repeats | UGP3-like, C-terminal hexapeptide repeats | Hexapep_UGP3_C | 9 |
IPR057389 | 57,389 | Phage zinc binding | Zn-bd_phage | Family | 103 | false | false | This entry represents a family of uncharacterised phage proteins that likely binds to zinc. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23903"
] | [
"Phage_zn_bind_2"
] | [
103
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dyella japonica DSM 16301",
"Viruses"
] | [
1,
102
] | 2 | [] | [] | 0 | true | Family | Phage zinc binding | Phage zinc binding | Zn-bd_phage | 6 |
IPR057391 | 57,391 | Phage zinc binding 4 | Zn-bd_phage_4 | Family | 60 | false | false | This entry represents a small family of uncharacterised phage proteins with a small zinc binding motif at the C-terminal end composed of a CXXC and CXXH motif. The N-terminal is composed of an α-helical hairpin. Structure prediction suggests that these two helices might mediate a homodimerisation interaction to form a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24128"
] | [
"Phage_zn_bind_4"
] | [
60
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Weiservirinae"
] | [
60
] | 1 | [] | [] | 0 | true | Family | Phage zinc binding 4 | Phage zinc binding 4 | Zn-bd_phage_4 | 5 |
IPR057392 | 57,392 | Phage zinc binding 5 | Zn-bd_phage_5 | Family | 35 | false | false | This entry contains a set of uncharacterised phage proteins that are likely to bind to Zn2+ ions using three conserved cysteines and a histidine. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24184"
] | [
"Phage_zn_bind_5"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes"
] | [
35
] | 1 | [] | [] | 0 | true | Family | Phage zinc binding 5 | Phage zinc binding 5 | Zn-bd_phage_5 | 6 |
IPR057393 | 57,393 | PIC/HAP1/IgA0-like, second beta-solenoid repeat region | PIC_HAP1_IgA0_b-sol2 | Domain | 904 | false | false | This entry represents the second solenoid-repeat region found in some serine peptidase autotransporters from bacteria, including IgA0 (Immunoglobulin A1 protease autotransporter), HAP1 (Adhesion and penetration protein autotransporter), Pic (Serine protease pic autotransporter), SepA and EspC. These proteins have been ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24078"
] | [
"Beta-sol_PIC_HAP1_IgA0_2nd"
] | [
904
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"3.4.21.-",
"PWY-7884",
"R-HSA-9760173",
"R-HSA-9927020"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884",
"REACTOME:R-HSA-9760173",
"REACTOME:R-HSA-9927020"
] | 4 | [
"1wxr",
"3ak5",
"3h09",
"3syj",
"5j44",
"9mne"
] | 6 | [
"PUB00052228",
"PUB00155548",
"PUB00155549",
"PUB00155550",
"PUB00155551"
] | [
"19393662",
"9695914",
"8932311",
"10531204",
"4199558"
] | [
"Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of haemophilus influenzae immunoglobulin A1 protease.",
"SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity.",
"Characterization of EspC, a 110-kilodalton ... | [
2009,
1998,
1996,
1999,
1973
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified Caudoviricetes"
] | [
902,
2
] | 2 | [] | [] | 0 | true | Domain | PIC/HAP1/IgA0-like, second beta-solenoid repeat region | PIC/HAP1/IgA0-like, second beta-solenoid repeat region | PIC_HAP1_IgA0_b-sol2 | 4 |
IPR057394 | 57,394 | PIGBOS1-like | PIGBOS1 | Family | 1,169 | false | false | This protein family includes human Protein PIGBOS1 and similar sequences from eukaryotes. PIGBOS1 plays a role in the regulation of the unfolded protein response triggered by the endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen [ ]. It is primarily found in the mitochon... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23670"
] | [
"PIGBOS1"
] | [
1169
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155798"
] | [
"31653868"
] | [
"Regulation of the ER stress response by a mitochondrial microprotein."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1169
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
1,
2,
1,
1,
5,
2,
1
] | 9 | true | Family | PIGBOS1-like | PIGBOS1-like | PIGBOS1 | 8 |
IPR057397 | 57,397 | 5MP1/2-like, HEAT domain | HEAT_5MP1_2 | Domain | 5,251 | false | false | This domain is formed by HEAT repeats, and it is found in the two human paralogs eIF5-mimic protein 1 and 2 (5MP1 and 5MP2) and related proteins. It is located at the N-terminal, and it likely contributes to the role of these proteins in translation regulation. It shares some sequence, structural, and functional simila... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25504"
] | [
"HEAT_5MP1_2"
] | [
5251
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094129",
"PUB00095038",
"PUB00160139",
"PUB00160140",
"PUB00160428",
"PUB00160429",
"PUB00160430",
"PUB00160431",
"PUB00160432"
] | [
"29470543",
"10075937",
"21745818",
"27325740",
"18435628",
"32228226",
"37279923",
"11524015",
"28981728"
] | [
"Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.",
"Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.",
"Mechanisms o... | [
2018,
1999,
2011,
2016,
2008,
2020,
2023,
2001,
2017
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5251
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
10,
1,
21,
13,
6,
7,
13
] | 8 | true | Domain | 5MP1/2-like, HEAT domain | 5MP1/2-like, HEAT domain | HEAT_5MP1_2 | 4 |
IPR057398 | 57,398 | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 2 | GRESAG4.1/3_peripasmic_2 | Domain | 575 | false | false | This entry represents the second periplasmic binding protein-like domain [ ] found in receptor-type adenylate cyclase GRESAG 4.1/3 and its homologues, mainly found in trypanosoma. It is usually found N-terminal to the adenylyl cyclase class-3/4/guanylyl cyclase domain (A/G_cyclase) ( ). In Trypanosoma brucei, the A/G_c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25493"
] | [
"Peripla_BP_A-cyclase"
] | [
575
] | 1 | [
"EC"
] | [
"4.6.1.1"
] | [
"EC:4.6.1.1"
] | 1 | [] | 0 | [
"PUB00025060",
"PUB00160433",
"PUB00160434",
"PUB00160435"
] | [
"11157750",
"37477489",
"1545803",
"8813663"
] | [
"Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state.",
"Dual localization of receptor-type adenylate cyclases and cAMP response protein 3 unveils the presence of two putative signaling microdomains in <i>Trypanosoma cruzi</i>.",
"A gene from the variant surface glycoprote... | [
2001,
2023,
1992,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
575
] | 1 | [] | [] | 0 | true | Domain | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 2 | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 2 | GRESAG4.1/3_peripasmic_2 | 9 |
IPR057399 | 57,399 | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 1 | GRESAG4.1/3_peripasmic_1 | Domain | 657 | false | false | This entry represents the first periplasmic binding protein-like domain [ ] found in receptor-type adenylate cyclase GRESAG 4.1/3 and its homologues, mainly found in trypanosoma. Receptor-type adenylate cyclase GRESAG 4.1/3 are class II adenylate cyclases (ACs) ( ) that occur as multiple isozymes in Trypanosoma brucei.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25495"
] | [
"Peripla_BP_A-cyclase_1"
] | [
657
] | 1 | [
"EC"
] | [
"4.6.1.1"
] | [
"EC:4.6.1.1"
] | 1 | [] | 0 | [
"PUB00160433",
"PUB00160434",
"PUB00160435"
] | [
"37477489",
"1545803",
"8813663"
] | [
"Dual localization of receptor-type adenylate cyclases and cAMP response protein 3 unveils the presence of two putative signaling microdomains in <i>Trypanosoma cruzi</i>.",
"A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagell... | [
2023,
1992,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Trypanosomatidae"
] | [
657
] | 1 | [] | [] | 0 | true | Domain | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 1 | Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 1 | GRESAG4.1/3_peripasmic_1 | 4 |
IPR057400 | 57,400 | ADGRF3/5-like, N-terminal domain | ADGRF3/5_N | Domain | 1,545 | false | false | This domain is found at the N-terminal end of Homo sapiens adhesion G-protein-coupled receptor F3 and F5 (ADGRF3/F5), orphan receptors. This domain is predicted to have an α-β configuration. In homo sapiens, ADGRF3 is a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically se... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25387"
] | [
"ADGRF3_N"
] | [
1545
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5683826",
"R-MMU-5683826",
"R-RNO-5683826"
] | [
"REACTOME:R-HSA-5683826",
"REACTOME:R-MMU-5683826",
"REACTOME:R-RNO-5683826"
] | 3 | [] | 0 | [
"PUB00160216",
"PUB00160436"
] | [
"36716818",
"34016966"
] | [
"Crystal Structure of the Extracellular Domains of GPR110.",
"Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue."
] | [
2023,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1545
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
2,
10
] | 4 | true | Domain | ADGRF3/5-like, N-terminal domain | ADGRF3/5-like, N-terminal domain | ADGRF3/5_N | 7 |
IPR057401 | 57,401 | Adt-1/2-like domain | Adt-1/2-like_dom | Domain | 928 | false | false | This domain is found in A disintegrin and metalloproteinase with thrombospondin motifs adt-1/2 from Caenorhabditis elegans and similar proteins. This domain is predicted to mostly acquire a β-structure. This domain is usually found in association with . It is also found in putative ADAM metallopeptidase and other uncha... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25379"
] | [
"Adt-1"
] | [
928
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160098",
"PUB00160099",
"PUB00160100"
] | [
"11796737",
"23621748",
"31439947"
] | [
"The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs.",
"Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism.",
"Crystal structure and substrate-induced activation of ADAMTS13."
] | [
2002,
2013,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
928
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster"
] | [
5,
6,
2
] | 3 | true | Domain | Adt-1/2-like domain | Adt-1/2-like domain | Adt-1/2-like_dom | 8 |
IPR057402 | 57,402 | BBC1/AIM3, cysteine proteinase-fold domain | AIM3_BBC1_C | Domain | 1,968 | false | false | This entry represents a C-terminal domain that contains a cysteine peptidase-like fold but appears to lack the conserved catalytic residues. It is mainly found in fungal proteins such as myosin tail region-interacting protein MTI1 (BBC1) in Saccharomyces cerevisiae and its orthologue SH3 domain-containing protein C23A1... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25459"
] | [
"AIM3_BBC1_C"
] | [
1968
] | 1 | [
"REACTOME"
] | [
"R-SPO-5668599"
] | [
"REACTOME:R-SPO-5668599"
] | 1 | [] | 0 | [
"PUB00033399",
"PUB00073760",
"PUB00160437",
"PUB00160438"
] | [
"11743162",
"11901111",
"31391237",
"15229592"
] | [
"A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules.",
"The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevis... | [
2002,
2002,
2019,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
69,
1897,
2
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | BBC1/AIM3, cysteine proteinase-fold domain | BBC1/AIM3, cysteine proteinase-fold domain | AIM3_BBC1_C | 7 |
IPR057403 | 57,403 | Aladin, seven-bladed propeller | Beta-prop_Aladin | Domain | 2,068 | false | false | This entry represents the seven-bladed β-propeller of Aladin and related proteins from eukaryotic organisms. Aladin (adracalin) is a nuclear envelope WD-repeat protein. It is encoded by the AAAS gene in humans. Aladin is a component of the nuclear pore complex, where it forms a heterodimer with nucleoporin NDC1 [ ]. It... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25460"
] | [
"Beta-prop_Aladin"
] | [
2068
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-8980692",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-D... | 57 | [
"7r5j",
"7r5k",
"7wkk",
"9hcj",
"9sob"
] | 5 | [
"PUB00098118",
"PUB00160110"
] | [
"26246606",
"35301439"
] | [
"The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.",
"Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex."
] | [
2015,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2068
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
5,
1,
5,
5,
3,
6,
3
] | 8 | true | Domain | Aladin, seven-bladed propeller | Aladin, seven-bladed propeller | Beta-prop_Aladin | 1 |
IPR057404 | 57,404 | Protein root UVB sensitive 6, N-terminal | RUS6_N | Domain | 560 | false | false | This domain is found at the N-terminal of Protein root UVB sensitive 6 from Arabidopsis thaliana (RUS6) and similar sequences from plants. RUS6 is required for normal embryo development [ ]. This domain is normally found associated with and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24162"
] | [
"RUS6_N"
] | [
560
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057512",
"PUB00057513",
"PUB00066759",
"PUB00072694",
"PUB00085159",
"PUB00154596"
] | [
"19515790",
"20562234",
"21511809",
"19075229",
"15266054",
"31268148"
] | [
"ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway.",
"Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 is required for polar auxin transport.",
"root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin... | [
2009,
2010,
2011,
2008,
2004,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
560
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
3,
10
] | 3 | true | Domain | Protein root UVB sensitive 6, N-terminal | Protein root UVB sensitive 6, N-terminal | RUS6_N | 5 |
IPR057405 | 57,405 | Proteasome-activating nucleotidase 2, N-terminal domain | PAN-2_N | Domain | 184 | false | false | This entry represents the N-termnal domain of archaeal Proteasome-activating nucleotidase 2 (PAN-2, previously known as Putative 26S proteasome regulatory subunit homologue, PRS2) and similar proteins. The function of this domain is unknown and it may be found in association with an AAA-ATPase domain ( ). The 26S prote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23900"
] | [
"PRS2_N"
] | [
184
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 11 | [] | 0 | [
"PUB00155483"
] | [
"20427185"
] | [
"Assembly, structure, and function of the 26S proteasome."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
181,
3
] | 2 | [] | [] | 0 | true | Domain | Proteasome-activating nucleotidase 2, N-terminal domain | Proteasome-activating nucleotidase 2, N-terminal domain | PAN-2_N | 6 |
IPR057406 | 57,406 | Pua-like domain | Pua-like_dom | Domain | 85 | false | false | Members of the PUA family play a crucial role in binding and recognising RNA and DNA with modified bases. They are often linked with Calcineurin-CE domains, indicating their function as sensors in prokaryotic antiviral immunity by recognising modified DNA in invasive DNA elements [ ]. This entry represents a domain oft... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24405"
] | [
"Pua-like"
] | [
85
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
85
] | 1 | [] | [] | 0 | true | Domain | Pua-like domain | Pua-like domain | Pua-like_dom | 6 |
IPR057407 | 57,407 | TANGO6, HEAT repeat | HEAT_TANGO6 | Domain | 2,039 | false | false | This region is found in the human Transport and Golgi organization protein 6 homolog (TANGO6) and similar proteins predominantly from animals and fungi. It is predicted to form HEAT repeats and is often found N-terminal to and . TANGO6 associates with COPI vesicles. Cytoplasmic TANGO6 tethers to COPI vesicle via a sign... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23565"
] | [
"ARM_TANGO6"
] | [
2039
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160190"
] | [
"38490996"
] | [
"TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2039
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
3,
2,
10
] | 4 | true | Domain | TANGO6, HEAT repeat | TANGO6, HEAT repeat | HEAT_TANGO6 | 7 |
IPR057408 | 57,408 | Proteasome-activating nucleotidase 2, AAA+ lid C-terminal domain | PAN-2_AAA_lid | Domain | 182 | false | false | This entry represents the C-terminal AAA+ lid domain of archaeal Proteasome-activating nucleotidase 2 (PAN-2, previously known as Putative 26S proteasome regulatory subunit homologue, PRS2) and similar proteins. This α-helical bundle is found in association with a core AAA-ATPase domain ( ). The 26S proteasome is a lar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23902"
] | [
"AAA_lid_PRS2_C"
] | [
182
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 11 | [] | 0 | [
"PUB00155483"
] | [
"20427185"
] | [
"Assembly, structure, and function of the 26S proteasome."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Intestinimonas massiliensis (ex Afouda et al. 2020)",
"ecological metagenomes"
] | [
178,
1,
3
] | 3 | [] | [] | 0 | true | Domain | Proteasome-activating nucleotidase 2, AAA+ lid C-terminal domain | Proteasome-activating nucleotidase 2, AAA+ lid C-terminal domain | PAN-2_AAA_lid | 1 |
IPR057410 | 57,410 | HVO_B0008-like, C-terminal domain | HVO_B0008-like_C | Domain | 77 | false | false | This entry represents a domain found at the C-terminal of uncharacterised proteins from halobacteria, including HVO_B0008 from Haloferax volcanii ( ). This domain is predicted to show a helix-turn-helix (HTH) fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25215"
] | [
"HVO_B0008_C"
] | [
77
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
77
] | 1 | [] | [] | 0 | true | Domain | HVO_B0008-like, C-terminal domain | HVO_B0008-like, C-terminal domain | HVO_B0008-like_C | 9 |
IPR057411 | 57,411 | Intraflagellar transport protein 122 homolog, TPR domain | TPR_IFT122 | Domain | 2,721 | false | false | This entry represents the TPR repeat domain that follows the two β-propeller domains in human Intraflagellar transport protein 122 homolog and similar proteins mainly found in animals. Intraflagellar transport protein 122 homolog (IFT122) is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25295"
] | [
"TPR_IFT122"
] | [
2721
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5610787",
"R-CEL-5620924",
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924",
"R-XTR-5610787"
] | [
"REACTOME:R-CEL-5610787",
"REACTOME:R-CEL-5620924",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-XTR-5610787"
] | 7 | [
"8bbe",
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8hme",
"8hmf",
"8ruy"
] | 13 | [
"PUB00101516",
"PUB00155528"
] | [
"29220510",
"36462505"
] | [
"Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.",
"IFT-A structure reveals carriages for membrane protein transport into cilia."
] | [
2018,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2721
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
2,
56,
3,
7
] | 6 | true | Domain | Intraflagellar transport protein 122 homolog, TPR domain | Intraflagellar transport protein 122 homolog, TPR domain | TPR_IFT122 | 6 |
IPR057412 | 57,412 | Integrator complex subunit 4/Protein SIEL, C-terminal Ig-like domain | INTS4_C | Domain | 2,253 | false | false | This entry represents the C-terminal domain of animal Integrator complex subunit 4 (INTS4) and plant Protein SIEL. The domain has been structurally identified near the INTS9 beta-CASP domain but is poorly resolved in current structures, suggesting flexibility. Its specific function remains to be determined. INTS4 is a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25458"
] | [
"INTS4_C"
] | [
2253
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6807505",
"R-DME-6807505",
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-DDI-6807505",
"REACTOME:R-DME-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 4 | [
"7bfp",
"7bfq",
"7cun",
"7pks",
"7sn8",
"7ycx",
"8r2d",
"8rbx",
"8rbz",
"8rc4",
"8yjb",
"9vd9"
] | 12 | [
"PUB00149412",
"PUB00151776",
"PUB00152015",
"PUB00155682",
"PUB00160145",
"PUB00160146",
"PUB00160477",
"PUB00160478"
] | [
"21924907",
"33548203",
"33243860",
"38570683",
"36180473",
"39032489",
"29471365",
"25124761"
] | [
"An essential protein that interacts with endosomes and promotes movement of the SHORT-ROOT transcription factor.",
"Structure of the catalytic core of the Integrator complex.",
"Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.",
"Structural basis of Integrator-dependent RN... | [
2011,
2021,
2020,
2024,
2022,
2024,
2018,
2014
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2253
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
2,
1,
11,
1,
9
] | 7 | true | Domain | Integrator complex subunit 4/Protein SIEL, C-terminal Ig-like domain | Integrator complex subunit 4/Protein SIEL, C-terminal Ig-like domain | INTS4_C | 6 |
IPR057413 | 57,413 | Integrator complex subunit 6-like, beta-barrel domain | Beta-barrel_INTS6 | Domain | 3,769 | false | false | This entry represents a domain found in the human Integrator complex subunit 6 (INTS6) and related proteins, including its paralogue Integrator complex subunit 6-like (INTS6L). The domain represented by this entry folds into a β-barrel structure with topological similarity to SPOC domains. INTS6 is a component of the I... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25462"
] | [
"Beta-barrel_INTS6"
] | [
3769
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6807505",
"R-DME-6807505",
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-DDI-6807505",
"REACTOME:R-DME-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 4 | [
"7cun",
"7pks",
"7ycx",
"8rbx",
"8rbz",
"8rc4",
"8yjb",
"9vd9"
] | 8 | [
"PUB00152015",
"PUB00155682"
] | [
"33243860",
"38570683"
] | [
"Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.",
"Structural basis of Integrator-dependent RNA polymerase II termination."
] | [
2020,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3769
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
1,
8,
5,
7
] | 6 | true | Domain | Integrator complex subunit 6-like, beta-barrel domain | Integrator complex subunit 6-like, beta-barrel domain | Beta-barrel_INTS6 | 7 |
IPR057415 | 57,415 | Cytochrome b6-f complex iron-sulfur subunit-like, transmembrane anchor | TM_PetC | Domain | 1,561 | false | false | This transmembrane domain, consisting of a single transmembrane helix, is found in Cytochrome b6-f complex iron-sulfur subunit (PetC) and related proteins. PetC, is a crucial component of the cytochrome b6f complex, which plays a central role in oxygenic photosynthesis [ , ]. PetC contains a [2Fe-2S] cluster, which is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25471"
] | [
"TM_PetC"
] | [
1561
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"7.1.1.6",
"PWY-101",
"PWY-8270",
"PWY-8271"
] | [
"EC:7.1.1.6",
"METACYC:PWY-101",
"METACYC:PWY-8270",
"METACYC:PWY-8271"
] | 4 | [
"1q90",
"1vf5",
"2d2c",
"2e74",
"2e75",
"2e76",
"2zt9",
"4h0l",
"4h13",
"4h44",
"4i7z",
"4ogq",
"4pv1",
"6rqf",
"7qrm",
"7r0w",
"7zxy",
"7zyv",
"9es7",
"9es8",
"9es9"
] | 21 | [
"PUB00022511",
"PUB00040375",
"PUB00160191",
"PUB00160192",
"PUB00160193"
] | [
"14647374",
"17498743",
"16371475",
"19189962",
"31723268"
] | [
"An atypical haem in the cytochrome b(6)f complex.",
"Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.",
"Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex.",
"Structure-Function, Sta... | [
2003,
2007,
2006,
2009,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
597,
961,
3
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
1,
7
] | 3 | true | Domain | Cytochrome b6-f complex iron-sulfur subunit-like, transmembrane anchor | Cytochrome b6-f complex iron-sulfur subunit-like, transmembrane anchor | TM_PetC | 5 |
IPR057416 | 57,416 | ISE2-like, SH3 domain | SH3_ISE2 | Domain | 573 | false | false | This predicted SH3 domain is found in DExH-box ATP-dependent RNA helicase DExH15 chloroplastic from Arabidopsis thaliana (ISE2) and similar plant proteins. ISE2 is involved in group II intron splicing. It is required during embryogenesis and is involved in post-transcriptional gene silencing [ , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25446"
] | [
"SH3_ISE2"
] | [
573
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160479",
"PUB00160480",
"PUB00160481"
] | [
"17601829",
"20434343",
"26147377"
] | [
"INCREASED SIZE EXCLUSION LIMIT 2 encodes a putative DEVH box RNA helicase involved in plasmodesmata function during Arabidopsis embryogenesis.",
"Loss of INCREASED SIZE EXCLUSION LIMIT (ISE)1 or ISE2 increases the formation of secondary plasmodesmata.",
"The chloroplastic DEVH-box RNA helicase INCREASED SIZE E... | [
2007,
2010,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
573
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
2
] | 3 | true | Domain | ISE2-like, SH3 domain | ISE2-like, SH3 domain | SH3_ISE2 | 5 |
IPR057418 | 57,418 | PH-like domain, kinetoplastida | PH-like_kinetoplastida | Domain | 37 | false | false | This entry represents a domain found at the C-terminal end of a small group of uncharacterised kinetoplastid proteins. This domain adopts a PH-like fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25402"
] | [
"PH_28"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
37
] | 1 | [] | [] | 0 | true | Domain | PH-like domain, kinetoplastida | PH-like domain, kinetoplastida | PH-like_kinetoplastida | 7 |
IPR057419 | 57,419 | PH-like domain 2, kinetoplastida | PH-like_2_kinetoplastida | Domain | 93 | false | false | This entry represents a domain found centrally in a small group of uncharacterised kinetoplastid proteins. This domain adopts a PH-like fold. It is found in proteins that have an α-helical solenoid N-terminal domain, a central PH domain (this entry) and a long α helix at the C terminus that presumably forms a coiled-co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25405"
] | [
"PH_30"
] | [
93
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
93
] | 1 | [] | [] | 0 | true | Domain | PH-like domain 2, kinetoplastida | PH-like domain 2, kinetoplastida | PH-like_2_kinetoplastida | 7 |
IPR057420 | 57,420 | Lambda-carrageenase, beta-propeller domain | Beta-prop_CGLA | Domain | 256 | false | false | This entry represents the β-propeller domain found at the N-terminal end of Pseudoalteromonas Lambda-carrageenases (CGLA), a protein that hydrolyses lambda-carrageenan with inversion of anomeric configuration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25292"
] | [
"Beta-prop_CGLA"
] | [
256
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160111"
] | [
"16926183"
] | [
"A novel enzyme, lambda-carrageenase, isolated from a deep-sea bacterium."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
33,
188,
22,
13
] | 4 | [] | [] | 0 | true | Domain | Lambda-carrageenase, beta-propeller domain | Lambda-carrageenase, beta-propeller domain | Beta-prop_CGLA | 3 |
IPR057421 | 57,421 | Lambda-carrageenase, middle domain | CGLA_M | Domain | 132 | false | false | This entry represents a domain found in the middle of Pseudoalteromonas Lambda-carrageenase (CGLA), a protein that hydrolyses lambda-carrageenan with inversion of anomeric configuration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25290"
] | [
"CGLA_M"
] | [
132
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160111"
] | [
"16926183"
] | [
"A novel enzyme, lambda-carrageenase, isolated from a deep-sea bacterium."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
132
] | 1 | [] | [] | 0 | true | Domain | Lambda-carrageenase, middle domain | Lambda-carrageenase, middle domain | CGLA_M | 4 |
IPR057422 | 57,422 | Lambda-carrageenase, C-terminal domain | CGLA_C | Domain | 117 | false | false | This entry represents the C-terminal domain of Pseudoalteromonas Lambda-carrageenase (CGLA), a protein that hydrolyses lambda-carrageenan with inversion of anomeric configuration [ ]. This domain is predicted to adopt a β-sandwich fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25291"
] | [
"CGLA_C"
] | [
117
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160111"
] | [
"16926183"
] | [
"A novel enzyme, lambda-carrageenase, isolated from a deep-sea bacterium."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
117
] | 1 | [] | [] | 0 | true | Domain | Lambda-carrageenase, C-terminal domain | Lambda-carrageenase, C-terminal domain | CGLA_C | 1 |
IPR057424 | 57,424 | Doublecortin domain-containing protein 1-like, ubiquitin domain | Ubiquitin_DCDC1 | Domain | 442 | false | false | This is the ubiquitin domain found in DCDC1 and similar proteins from animals. Doublecortin domain-containing protein 1 (DCDC1), also known as DCDC5, is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. DCDC1 is exp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25510"
] | [
"Ubiquitin_DCDC1"
] | [
442
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093782"
] | [
"22159412"
] | [
"Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
442
] | 1 | [
"Homo sapiens"
] | [
2
] | 1 | true | Domain | Doublecortin domain-containing protein 1-like, ubiquitin domain | Doublecortin domain-containing protein 1-like, ubiquitin domain | Ubiquitin_DCDC1 | 9 |
IPR057425 | 57,425 | DUF2921, lipocalin-like domain | DUF2921_N | Domain | 2,597 | false | false | This entry represents an eight-stranded flattened β barrel domain which shows structural similarity to the lipocalin fold. The domain shows is found in three copies towards the N terminus of DUF2921 family proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25333"
] | [
"DUF2921_N"
] | [
2597
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta",
"Shewanella electrica"
] | [
2596,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
22,
11
] | 3 | true | Domain | DUF2921, lipocalin-like domain | DUF2921, lipocalin-like domain | DUF2921_N | 4 |
IPR057426 | 57,426 | E3 ubiquitin-protein ligase RNF31, third UBA domain | RNF31_UBA_3 | Domain | 996 | false | false | This domain is found in human E3 ubiquitin-protein ligase RNF31 and similar animal proteins. RNF31 is a component of the LUBAC complex which conjugates linear polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. This domain is often found C-terminal of . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25163"
] | [
"UBA_RNF31"
] | [
996
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-MMU-5357786",
"R-MMU-5357905",
"R-MMU-5357956"
] | [
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-5357956",
"REACTOME:R-MMU-5357786",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-5357956"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
996
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
4,
3
] | 4 | true | Domain | E3 ubiquitin-protein ligase RNF31, third UBA domain | E3 ubiquitin-protein ligase RNF31, third UBA domain | RNF31_UBA_3 | 2 |
IPR057427 | 57,427 | E3 ubiquitin-protein ligase WAV3-like, C-terminal domain | WAV3_C | Domain | 1,075 | false | false | This domain is found towards the C-terminal end of E3 ubiquitin -protein ligase WAV3, WAVH1, WAVH2 and EDA40 from Arabidopsis thaliana and similar plant proteins. WAV3 is involved in the regulation of root growth and acts as a positive regulator of root gravitropism [ ]. This domain is predicted to show an all-α config... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25243"
] | [
"WAV3_C"
] | [
1075
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [
"PUB00150789"
] | [
"22122664"
] | [
"The wavy growth 3 E3 ligase family controls the gravitropic response in Arabidopsis roots."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
1075
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
6,
7
] | 3 | true | Domain | E3 ubiquitin-protein ligase WAV3-like, C-terminal domain | E3 ubiquitin-protein ligase WAV3-like, C-terminal domain | WAV3_C | 1 |
IPR057430 | 57,430 | LDLRAD1-like, C-terminal domain | LDLRAD1_C | Domain | 817 | false | false | This domain is found at the C-terminal end of human Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) and similar sequences from vertebrates. This domain is often found associated with . Its specific function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25241"
] | [
"LDLRAD1_C"
] | [
817
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
817
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1
] | 3 | true | Domain | LDLRAD1-like, C-terminal domain | LDLRAD1-like, C-terminal domain | LDLRAD1_C | 7 |
IPR057431 | 57,431 | Light dependent period A-like, Fe-S cluster-binding domain | LdpA_Fe-S-bd | Domain | 2,752 | false | false | This entry represents the Fe-S cluster-binding domain of Light dependent period A (LpdA) from Synechococcus elongatus, which is inserted in the TIM barrel domain ( ). LpdA plays a role in controlling the redox state in cyanobacteria to modulate its circadian clock [ , ]. This entry also includes uncharacterised sequenc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25160"
] | [
"LdpA_Fe-S-bd"
] | [
2752
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053298",
"PUB00075347",
"PUB00159046"
] | [
"12562813",
"23995635",
"15775978"
] | [
"ldpA encodes an iron-sulfur protein involved in light-dependent modulation of the circadian period in the cyanobacterium Synechococcus elongatus PCC 7942.",
"Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.",
"LdpA: a co... | [
2003,
2014,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
91,
2000,
629,
32
] | 4 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
10
] | 2 | true | Domain | Light dependent period A-like, Fe-S cluster-binding domain | Light dependent period A-like, Fe-S cluster-binding domain | LdpA_Fe-S-bd | 5 |
IPR057432 | 57,432 | Lin-15A/B-like domain | Lin-15A/B-like_dom | Domain | 361 | false | false | This domain is found in a group of proteins from Caenorhabditis, including Protein lin-15A/B from Caenorhabditis elegans, synthetic multivulva class A/B proteins respectively that are required to repress the induction of vulval development [ , , ]. Protein lin-56, which also belongs to this group of proteins, is requir... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25375"
] | [
"Lin-15B"
] | [
361
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090560",
"PUB00090561",
"PUB00160484",
"PUB00160485"
] | [
"7982579",
"8054684",
"11463372",
"21196525"
] | [
"The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.",
"The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.",
"dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. ... | [
1994,
1994,
2001,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Rhabditina"
] | [
361
] | 1 | [
"Caenorhabditis elegans"
] | [
11
] | 1 | true | Domain | Lin-15A/B-like domain | Lin-15A/B-like domain | Lin-15A/B-like_dom | 4 |
IPR057433 | 57,433 | Lipase maturation factor 1/2, C-terminal domain | LMF1/2_C | Domain | 5,656 | false | false | This entry represents the C-terminal domain of a family transmembrane proteins that includes the lipase maturation factors 1 and 2 (LMF1/2). Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [ ]. LMF1 acts as a chaperone required for maturation and transport of active lipoprotein lipas... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25179"
] | [
"LMF1_C"
] | [
5656
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8963889",
"R-MMU-8963889",
"R-RNO-8963889",
"R-XTR-8963889"
] | [
"REACTOME:R-HSA-8963889",
"REACTOME:R-MMU-8963889",
"REACTOME:R-RNO-8963889",
"REACTOME:R-XTR-8963889"
] | 4 | [] | 0 | [
"PUB00057509",
"PUB00057511",
"PUB00098585"
] | [
"17994020",
"20543905",
"24909692"
] | [
"Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.",
"Mechanisms of lipase maturation.",
"Purification, cellular levels, and functional domains of lipase maturation factor 1."
] | [
2007,
2010,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
59,
2089,
3497,
11
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
4,
4,
7
] | 5 | true | Domain | Lipase maturation factor 1/2, C-terminal domain | Lipase maturation factor 1/2, C-terminal domain | LMF1/2_C | 5 |
IPR057434 | 57,434 | Lipase maturation factor 1/2, N-terminal domain | LMF1/2_N | Domain | 5,519 | false | false | This entry represents the N-terminal domain of a family transmembrane proteins that includes the lipase maturation factors 1 and 2 (LMF1/2). Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [ ]. LMF1 acts as a chaperone required for maturation and transport of active lipoprotein lipas... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF06762"
] | [
"LMF1"
] | [
5519
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8963889",
"R-MMU-8963889",
"R-RNO-8963889",
"R-XTR-8963889"
] | [
"REACTOME:R-HSA-8963889",
"REACTOME:R-MMU-8963889",
"REACTOME:R-RNO-8963889",
"REACTOME:R-XTR-8963889"
] | 4 | [] | 0 | [
"PUB00057509",
"PUB00057511",
"PUB00098585"
] | [
"17994020",
"20543905",
"24909692"
] | [
"Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.",
"Mechanisms of lipase maturation.",
"Purification, cellular levels, and functional domains of lipase maturation factor 1."
] | [
2007,
2010,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
56,
2090,
3359,
14
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
6,
5,
7
] | 5 | true | Domain | Lipase maturation factor 1/2, N-terminal domain | Lipase maturation factor 1/2, N-terminal domain | LMF1/2_N | 4 |
IPR057435 | 57,435 | Lips | Lips | Family | 836 | false | false | This entry corresponds to an uncharacterised protein family. A structure prediction of the dimer of this protein gives rise to a large complex with a pair of hydrophobic lips that might interact with a cell membrane. STRING networks suggest that this protein may interact with RNA polymerase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25228"
] | [
"Lips"
] | [
836
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae",
"hydrothermal vent metagenome"
] | [
826,
9,
1
] | 3 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Lips | Lips | Lips | 4 |
IPR057436 | 57,436 | Lnb-like, transmembrane domain | 5TMH_Lnb | Domain | 2,066 | false | false | This domain is found C-terminal in Lipoprotein N-acyltransferase Lnb from Bacteroides and related uncharacterised bacterial proteins. Lnb functions as a lipoprotein N-acyltransferase in its native cell environment [ ]. It is composed of two domains, N-terminal periplasmic domain and C-terminal α-helical transmembrane d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25221"
] | [
"5TMH_Lnb"
] | [
2066
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00158892"
] | [
"39495918"
] | [
"Identification and characterization of the lipoprotein <i>N</i>-acyltransferase in <i>Bacteroides</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae",
"unclassified sequences"
] | [
2024,
1,
41
] | 3 | [] | [] | 0 | true | Domain | Lnb-like, transmembrane domain | Lnb-like, transmembrane domain | 5TMH_Lnb | 5 |
IPR057437 | 57,437 | PIF1/LRR1, pleckstrin homology domain | PIF1/LRR1_PH | Domain | 2,594 | false | false | This entry represents the pleckstrin homology (PH) domain found in the N-terminal region of human ATP-dependent DNA helicase PIF1, Leucine-rich repeat protein 1 (LRR1), and similar sequences specific to animals. PIF is a DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25344"
] | [
"PH_LRR1"
] | [
2594
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.3",
"R-HSA-171319",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-171319",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-171319"
] | [
"EC:5.6.2.3",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-171319",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-171319"
] | 8 | [
"7plo",
"7shk",
"7shl"
] | 3 | [
"PUB00053693",
"PUB00060101",
"PUB00154918",
"PUB00160162",
"PUB00160486",
"PUB00160487"
] | [
"17172855",
"15601820",
"34700328",
"34850944",
"19700773",
"23657261"
] | [
"Human PIF helicase is cell cycle regulated and associates with telomerase.",
"VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.",
"A conserved mechanism for regulating replisome disassembly in eukaryotes.",
"Structure of CRL2Lrr1, the E3 ubiq... | [
2006,
2004,
2021,
2021,
2009,
2013
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2594
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
7,
7,
6
] | 6 | true | Domain | PIF1/LRR1, pleckstrin homology domain | PIF1/LRR1, pleckstrin homology domain | PIF1/LRR1_PH | 4 |
IPR057439 | 57,439 | Angiopoietin-1/2/4 domain | ANG-1/2/4 | Domain | 3,242 | false | false | This presumed domain is found in Angiopoietin-1, 2 and 4 (ANG-1/2/4) and similar animal sequences. This domain, which is predicted to adopt an α-helical configuration, is often associated with . Angiopoietin-1 (ANG-1) plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25443"
] | [
"ANG-1"
] | [
3242
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-210993",
"R-BTA-5673001",
"R-CFA-210993",
"R-HSA-210993",
"R-HSA-5673001",
"R-MMU-210993",
"R-MMU-5673001",
"R-RNO-210993",
"R-RNO-5673001"
] | [
"REACTOME:R-BTA-210993",
"REACTOME:R-BTA-5673001",
"REACTOME:R-CFA-210993",
"REACTOME:R-HSA-210993",
"REACTOME:R-HSA-5673001",
"REACTOME:R-MMU-210993",
"REACTOME:R-MMU-5673001",
"REACTOME:R-RNO-210993",
"REACTOME:R-RNO-5673001"
] | 9 | [] | 0 | [
"PUB00160490"
] | [
"12759249"
] | [
"Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Maritimibacter harenae",
"Natrarchaeobaculum sulfurireducens",
"marine sediment metagenome"
] | [
3239,
1,
1,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
9,
10,
9
] | 4 | true | Domain | Angiopoietin-1/2/4 domain | Angiopoietin-1/2/4 domain | ANG-1/2/4 | 8 |
IPR057440 | 57,440 | At1g68980-like, TPR repeats | At1g68980-like_TPR | Domain | 1,509 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found at the N-terminal end of At1g68980 from Arabidopsis thaliana and similar plant sequences. At1g68980 is implicated in mitochondrial stress responses, as mutations in mitochondrial proteins, alter hormone concentrations (e.g., gibberellic acid and ethylene) a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25245"
] | [
"TPR_At1g68980"
] | [
1509
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001313",
"PUB00005443",
"PUB00005695",
"PUB00014195",
"PUB00160491"
] | [
"9482716",
"7667876",
"1882418",
"14659697",
"30537160"
] | [
"The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.",
"Tetratrico peptide repeat interactions: to TPR or not to TPR?",
"The TPR snap helix: a novel protein repeat motif from mitosis to transcription.",
"TPR proteins: the versati... | [
1998,
1995,
1991,
2003,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1509
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
9,
8
] | 3 | true | Domain | At1g68980-like, TPR repeats | At1g68980-like, TPR repeats | At1g68980-like_TPR | 2 |
IPR057441 | 57,441 | At2g24240-like, C-terminal beta-propeller | Beta_prop_At2g24240 | Domain | 2,057 | false | false | This is the β-propeller found at the C-terminal end of BTB/POZ domain-containing protein At2g24240 from Arabidopsis thaliana and similar plant proteins. The function of At2g24240 remains uncharacterised. However, given the presence of a BTB/POZ domain ( ) and a C-terminal β-propeller, it is likely to be involved in ubi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25279"
] | [
"Beta_prop_At2g24240"
] | [
2057
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2057
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
14,
6
] | 3 | true | Domain | At2g24240-like, C-terminal beta-propeller | At2g24240-like, C-terminal beta-propeller | Beta_prop_At2g24240 | 2 |
IPR057442 | 57,442 | At4g14310, 8-bladed propeller | Beta-prop_At4g14310 | Domain | 646 | false | false | This domain is found in the KIN14B-interacting protein At4g14310 from Arabidopsis thaliana and related proteins. This domain is predicted to fold into an eight-bladed β-propeller. At4g14310 may be implicated in division plane orientation during plant cell division, a process critical for proper embryonic development an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25465"
] | [
"Beta-prop_At4g14310"
] | [
646
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098484",
"PUB00160492",
"PUB00160493",
"PUB00160494"
] | [
"20706207",
"30742612",
"34705238",
"36074053"
] | [
"Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.",
"Cell geometry determines symmetric and asymmetric division plane selection in Arabidopsis early embryos.",
"Studying Cell Division Plane Positioning in Early-Stage Embryos.",
"Defects in division plane positioning ... | [
2010,
2019,
2022,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
646
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
6
] | 3 | true | Domain | At4g14310, 8-bladed propeller | At4g14310, 8-bladed propeller | Beta-prop_At4g14310 | 8 |
IPR057443 | 57,443 | At5g54830-like domain | At5g54830-like | Domain | 1,484 | false | false | This domain is found in At5g54830 from Arabidopsis thaliana and similar plant proteins such as Cytochrome b561, DM13 and DOMON domain-containing proteins. It is predicted to adopt an all-β configuration. The function of this domain has not been characterised yet. This domain is also found in Protein Skeletor isoforms B... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25489"
] | [
"At5g54830"
] | [
1484
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
1479,
5
] | 2 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
3,
5,
6
] | 4 | true | Domain | At5g54830-like domain | At5g54830-like domain | At5g54830-like | 4 |
IPR057444 | 57,444 | AtC3H23-like, CCCH zinc finger domain | Znf-CCCH_AtC3H23-like | Domain | 6,257 | false | false | This CCCH-type zinc finger is found in Zinc finger CCCH domain-containing protein 23 (AtC3H23, ) and similar plant proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25512"
] | [
"zf-CCCH_AtC3H23"
] | [
6257
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005945",
"PUB00005946"
] | [
"9703499",
"10330172"
] | [
"Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.",
"Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA."
] | [
1998,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6257
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
43,
18,
47
] | 3 | true | Domain | AtC3H23-like, CCCH zinc finger domain | AtC3H23-like, CCCH zinc finger domain | Znf-CCCH_AtC3H23-like | 4 |
IPR057445 | 57,445 | ATM-like, TPR repeat | ATM_TPR | Repeat | 793 | false | false | This region of tetratricopeptide (TPR)-like repeats is found in Serine/threonine-protein kinase ATM from Arabidopsis thaliana and similar plant proteins. ATM acts as a DNA damage sensor upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA) [ , ]. It regulate DNA d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25360"
] | [
"TPR_ATM"
] | [
793
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001313",
"PUB00005443",
"PUB00005695",
"PUB00014195",
"PUB00062186",
"PUB00062187",
"PUB00062189",
"PUB00062190",
"PUB00062192",
"PUB00062193",
"PUB00062194",
"PUB00062195",
"PUB00062196",
"PUB00062197",
"PUB00062198",
"PUB00062199",
"PUB00088376"
] | [
"9482716",
"7667876",
"1882418",
"14659697",
"11571274",
"19448632",
"10973490",
"15680327",
"12556884",
"16858402",
"10873394",
"8988033",
"9843217",
"9707615",
"10550055",
"10766245",
"26586427"
] | [
"The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.",
"Tetratrico peptide repeat interactions: to TPR or not to TPR?",
"The TPR snap helix: a novel protein repeat motif from mitosis to transcription.",
"TPR proteins: the versati... | [
1998,
1995,
1991,
2003,
2001,
2009,
2000,
2005,
2003,
2006,
2000,
1997,
1998,
1998,
1999,
2000,
2015
] | 17 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
793
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
3,
21
] | 3 | true | Repeat | ATM-like, TPR repeat | ATM-like, TPR repeat | ATM_TPR | 1 |
IPR057446 | 57,446 | PH domain-like, bacteria | PH_bac | Domain | 2,820 | false | false | This entry represents a PH domain found in actinomycete bacteria proteins. This domain contains a transmembrane helix, which likely anchors the proteins in the bacterial membrane. According to STRING these proteins are functionally connected to large biosynthetic operon proteins. These proteins possibly act as structur... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25362"
] | [
"bPH_11"
] | [
2820
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003918",
"PUB00014130",
"PUB00057292",
"PUB00057293",
"PUB00080401",
"PUB00080402"
] | [
"7634082",
"14594214",
"8074669",
"7522330",
"22728242",
"17233582"
] | [
"More meanders and sandwiches.",
"Membrane targeting by pleckstrin homology domains.",
"Binding of PH domains of beta-adrenergic receptor kinase and beta-spectrin to WD40/beta-transducin repeat containing regions of the beta-subunit of trimeric G-proteins.",
"The pleckstrin homology domain of Bruton tyrosine ... | [
1994,
2004,
1994,
1994,
2012,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"freshwater metagenome"
] | [
2796,
24
] | 2 | [] | [] | 0 | true | Domain | PH domain-like, bacteria | PH domain-like, bacteria | PH_bac | 6 |
IPR057447 | 57,447 | Bbp19-like phage | Bbp19-like_phage | Domain | 800 | false | false | This entry represents a domain found in uncharacterised phage protein, it is composed of three α helices. There is some evidence from structure predictions that this protein may homodimerise. These dimers are predicted to form a ring of eight dimers. This entry includes the Bbp19 protein (also known as Endopeptidase, )... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25181"
] | [
"Phage_Bbp19"
] | [
800
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
667,
2,
72,
59
] | 4 | [] | [] | 0 | true | Domain | Bbp19-like phage | Bbp19-like phage | Bbp19-like_phage | 2 |
IPR057449 | 57,449 | BPTI-like, C-terminal domain | BPTI_C_nem | Domain | 117 | false | false | This entry represents a BPTI-like domain found exclusively in nematodes, primarily within the class Chromadorea. The domain is well-represented across multiple nematode clades including Rhabditina, Tylenchina, and Spirurina. It is found in proteins such as LON-8 in C. elegans, which contains a single copy of this domai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25315"
] | [
"BPTI_nem"
] | [
117
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
117
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | BPTI-like, C-terminal domain | BPTI-like, C-terminal domain | BPTI_C_nem | 8 |
IPR057450 | 57,450 | BRINP, EGF domain | BRINP_EGF | Domain | 2,895 | false | false | This predicted EGF domain is found in BMP/retinoic acid-inducible neural-specific proteins (BRINP) 1, 2 and 3. This domain is often found between and . BRINP proteins are involved in neurogenesis and brain development. These proteins play a role in inhibiting neuronal cell proliferation by negatively regulating cell cy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25415"
] | [
"EGF_BRNP1-3"
] | [
2895
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078236",
"PUB00160495"
] | [
"20025061",
"15193423"
] | [
"Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.",
"Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family."
] | [
2010,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
2895
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
3,
9
] | 4 | true | Domain | BRINP, EGF domain | BRINP, EGF domain | BRINP_EGF | 7 |
IPR057451 | 57,451 | BRWD/PHIP, ancillary-like domain | BRWD/PHIP_AD | Domain | 6,152 | false | false | This entry represents a conserved domain found in bromodomain and WD repeat-containing proteins (BRWD) and PH-interacting protein (PHIP). This domain shows structural similarity to the ancillary domain of Auxin Response Factors ( ). It is found in BRWD1, BRWD3 and PHIP proteins, which are involved in transcriptional re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25313"
] | [
"BRWD_AD"
] | [
6152
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-1266695",
"R-DDI-3247509",
"R-DDI-9013418",
"R-HSA-1266695",
"R-HSA-3247509",
"R-HSA-9013418",
"R-MMU-1266695",
"R-MMU-3247509",
"R-MMU-9013418"
] | [
"REACTOME:R-DDI-1266695",
"REACTOME:R-DDI-3247509",
"REACTOME:R-DDI-9013418",
"REACTOME:R-HSA-1266695",
"REACTOME:R-HSA-3247509",
"REACTOME:R-HSA-9013418",
"REACTOME:R-MMU-1266695",
"REACTOME:R-MMU-3247509",
"REACTOME:R-MMU-9013418"
] | 9 | [] | 0 | [
"PUB00160496",
"PUB00160497"
] | [
"12077364",
"18437052"
] | [
"Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway.",
"Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer."
] | [
2002,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6152
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
24,
7,
2,
10,
5,
4,
13,
20
] | 8 | true | Domain | BRWD/PHIP, ancillary-like domain | BRWD/PHIP, ancillary-like domain | BRWD/PHIP_AD | 1 |
IPR057452 | 57,452 | BRWD/PHIP, N-terminal domain | BRWD/PHIP_N | Domain | 4,629 | false | false | This domain is found at the N-terminal of Bromodomain and WD repeat-containing protein (BRWD) and WD repeat-containing proteins (BRWD) and PH-interacting protein (PHIP). It is found in BRWD1, BRWD3 and PHIP proteins, which are involved in transcriptional regulation. BRWD1 and BRWD3 proteins contain multiple bromodomain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25437"
] | [
"BRWD1_N"
] | [
4629
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-1266695",
"R-DDI-3247509",
"R-DDI-9013418",
"R-HSA-1266695",
"R-HSA-3247509",
"R-HSA-9013418",
"R-MMU-1266695",
"R-MMU-3247509",
"R-MMU-9013418"
] | [
"REACTOME:R-DDI-1266695",
"REACTOME:R-DDI-3247509",
"REACTOME:R-DDI-9013418",
"REACTOME:R-HSA-1266695",
"REACTOME:R-HSA-3247509",
"REACTOME:R-HSA-9013418",
"REACTOME:R-MMU-1266695",
"REACTOME:R-MMU-3247509",
"REACTOME:R-MMU-9013418"
] | 9 | [] | 0 | [
"PUB00160496",
"PUB00160497"
] | [
"12077364",
"18437052"
] | [
"Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway.",
"Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer."
] | [
2002,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4629
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
18,
6,
1,
10,
12,
3,
11,
9
] | 8 | true | Domain | BRWD/PHIP, N-terminal domain | BRWD/PHIP, N-terminal domain | BRWD/PHIP_N | 4 |
IPR057453 | 57,453 | BSD2, cysteine rich domain | BSD2_CRD | Domain | 1,002 | false | false | This domain is found in the chloroplastic Protein BUNDLE SHEATH DEFECTIVE 2 (BSD2) from Arabidopsis thaliana and related proteins. This domain has a hairpin architecture arranged around two Zn atoms, each coordinated by four cysteines [ ]. Proteins with this domain contain a highly conserved CxxCxGxG sequence motif. Ch... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25436"
] | [
"BSD2_CRD"
] | [
1002
] | 1 | [] | [] | [] | 0 | [
"6ekb",
"6ekc",
"8ilb",
"8ilm",
"9ci1",
"9ci2"
] | 6 | [
"PUB00160115"
] | [
"29217567"
] | [
"Plant RuBisCo assembly in <i>E. coli</i> with five chloroplast chaperones including BSD2."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
1000
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
2
] | 3 | true | Domain | BSD2, cysteine rich domain | BSD2, cysteine rich domain | BSD2_CRD | 2 |
IPR057454 | 57,454 | Bud3, C-terminal PH domain | Bud3_C | Domain | 1,205 | false | false | This entry represents a pleckstrin homology (PH) domain found at the C-terminal of Bud3. This PH domain may be involved in membrane targeting of Bud3. The Bud3 is involved in bud site selection and septation processes. It is crucial for proper septum positioning and construction during cell division. It acts as landmar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25351"
] | [
"PH_BUD3_C"
] | [
1205
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003918",
"PUB00014130",
"PUB00057292",
"PUB00057293",
"PUB00080401",
"PUB00080402",
"PUB00160498"
] | [
"7634082",
"14594214",
"8074669",
"7522330",
"22728242",
"17233582",
"12612612"
] | [
"More meanders and sandwiches.",
"Membrane targeting by pleckstrin homology domains.",
"Binding of PH domains of beta-adrenergic receptor kinase and beta-spectrin to WD40/beta-transducin repeat containing regions of the beta-subunit of trimeric G-proteins.",
"The pleckstrin homology domain of Bruton tyrosine ... | [
1994,
2004,
1994,
1994,
2012,
2007,
2003
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1205
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Bud3, C-terminal PH domain | Bud3, C-terminal PH domain | Bud3_C | 8 |
IPR057455 | 57,455 | UBFD1, PH-like C-terminal domain | UBFD1_C | Domain | 1,681 | false | false | This entry represents a C-terminal pleckstrin homology (PH)-like domain found in the ubiquitin domain-containing protein UBFD1 and related eukaryotic proteins. The specific role of this domain in UBFD1 function remains to be determined. Pleckstrin homology (PH) domains are small modular domains that occur in a large va... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25343"
] | [
"PH_UBFD1_C"
] | [
1681
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003918",
"PUB00014130",
"PUB00057292",
"PUB00057293",
"PUB00080401",
"PUB00080402"
] | [
"7634082",
"14594214",
"8074669",
"7522330",
"22728242",
"17233582"
] | [
"More meanders and sandwiches.",
"Membrane targeting by pleckstrin homology domains.",
"Binding of PH domains of beta-adrenergic receptor kinase and beta-spectrin to WD40/beta-transducin repeat containing regions of the beta-subunit of trimeric G-proteins.",
"The pleckstrin homology domain of Bruton tyrosine ... | [
1994,
2004,
1994,
1994,
2012,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1681
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
2,
3
] | 4 | true | Domain | UBFD1, PH-like C-terminal domain | UBFD1, PH-like C-terminal domain | UBFD1_C | 3 |
IPR057456 | 57,456 | C17orf113, probable zinc finger | Znf_C17orf113 | Domain | 2,840 | false | false | This domain is found in the human uncharacterised protein C17orf113 and related proteins. It contains two pairs of invariant cysteine and histidine residues that may be involved in metal coordination. This domain contains a zinc finger like fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25431"
] | [
"zf-C17orf113"
] | [
2840
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Solemya velum gill symbiont",
"invertebrate metagenome"
] | [
2838,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
3,
3,
2,
2,
2,
15
] | 7 | true | Domain | C17orf113, probable zinc finger | C17orf113, probable zinc finger | Znf_C17orf113 | 7 |
IPR057457 | 57,457 | CAPS, C2 domain | CAPS_C2 | Domain | 6,966 | false | false | This entry represents the C2 domain found in CAPS proteins, which are essential regulators of dense-core vesicle exocytosis. This domain has a typical C2 superfamily fold consisting of an eight-stranded β-sandwich but lacks calcium-binding capacity. Instead, it works together with the adjacent PH domain through a conse... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25341"
] | [
"C2_CAPS"
] | [
6966
] | 1 | [] | [] | [] | 0 | [
"7vs3"
] | 1 | [
"PUB00000918",
"PUB00002815",
"PUB00002925",
"PUB00053763",
"PUB00081923",
"PUB00160116"
] | [
"7697723",
"8253763",
"7559667",
"15820695",
"22453964",
"36863339"
] | [
"Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.",
"A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.",
"Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.",
"CAPS1 ... | [
1995,
1993,
1995,
2005,
2012,
2023
] | 6 | [
"IPR000008"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
6966
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
58,
2,
13,
11,
20
] | 6 | true | Domain | CAPS, C2 domain | CAPS, C2 domain | CAPS_C2 | 1 |
IPR057458 | 57,458 | GRDP, C2 domain | GRDP_C2 | Domain | 1,109 | false | false | This entry represents a C2 domain found in GRDP1 and GRDP2 proteins. Glycine-rich domain-containing proteins (GRDPs) play a regulatory role in abscisic acid (ABA) signalling and tolerance to abiotic stress during germination. They may be involved in the regulation of the ABI transcriptional factors [ ] and in the devel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25334"
] | [
"C2_GRDP"
] | [
1109
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000918",
"PUB00002815",
"PUB00002925",
"PUB00077560",
"PUB00081923",
"PUB00096853",
"PUB00160499"
] | [
"7697723",
"8253763",
"7559667",
"25653657",
"22453964",
"28285133",
"29568308"
] | [
"Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.",
"A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.",
"Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.",
"Overex... | [
1995,
1993,
1995,
2014,
2012,
2017,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
1109
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
2,
8
] | 3 | true | Domain | GRDP, C2 domain | GRDP, C2 domain | GRDP_C2 | 6 |
IPR057459 | 57,459 | SYDE1/2, C2 domain | SYDE1/2_C2 | Domain | 2,412 | false | false | This entry represents the C2 domain found in synapse-defective Rho GTPase-activating proteins (SYDE). This domain appears to be specific to vertebrates and is notably conserved between SYDE1 and SYDE2, though SYDE2 shows higher sequence conservation across species. The Rho GTPase-activating proteins function as activat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25336"
] | [
"C2_SYDE"
] | [
2412
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-9013148",
"R-CEL-9013149",
"R-CEL-9013404",
"R-CEL-9013406",
"R-CEL-9013409",
"R-CEL-9013423",
"R-CEL-9035034",
"R-DME-9013148",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013406",
"R-DME-9013409",
"R-DME-9013423",
"R-DME-9035034",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-90134... | [
"REACTOME:R-CEL-9013148",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013404",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013409",
"REACTOME:R-CEL-9013423",
"REACTOME:R-CEL-9035034",
"REACTOME:R-DME-9013148",
"REACTOME:R-DME-9013149",
"REACTOME:R-DME-9013404",
"REACTOME:R-DME-9013406",
"REACTOM... | 32 | [] | 0 | [
"PUB00000918",
"PUB00002815",
"PUB00002925",
"PUB00081923",
"PUB00160500"
] | [
"7697723",
"8253763",
"7559667",
"22453964",
"27917469"
] | [
"Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.",
"A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.",
"Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.",
"The ro... | [
1995,
1993,
1995,
2012,
2017
] | 5 | [
"IPR000008"
] | [] | 1 | 0 | 1 | [
"Metazoa"
] | [
2412
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
7,
8,
6,
5
] | 6 | true | Domain | SYDE1/2, C2 domain | SYDE1/2, C2 domain | SYDE1/2_C2 | 8 |
IPR057460 | 57,460 | CAF17, C-terminal domain | CAF17_C | Domain | 7,244 | false | false | This entry represents the C-terminal domain in CAF17 and similar eukaryotic proteins. This domain contains a β-barrel fold. CAF17 proteins are mitochondrial putative transferases involved in various cellular processes. These proteins are implicated in the maturation of mitochondrial iron-sulphur (Fe/S) proteins, which ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25455"
] | [
"Beta-barrel_CAF17_C"
] | [
7244
] | 1 | [] | [] | [] | 0 | [
"6geu",
"6qe3",
"6qe4",
"7z3h"
] | 4 | [
"PUB00160108",
"PUB00160109",
"PUB00160522"
] | [
"30269484",
"30950402",
"20489182"
] | [
"IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex.",
"In-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity.",
"A role for tetrahydrofolates in the metabolism... | [
2018,
2019,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3529,
3669,
46
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea ma... | [
3,
1,
1,
1,
2,
1,
3,
2,
1,
1,
3
] | 11 | true | Domain | CAF17, C-terminal domain | CAF17, C-terminal domain | CAF17_C | 5 |
IPR057461 | 57,461 | Calcyphosin-2, PH domain | CAYP2_PH | Domain | 422 | false | false | This entry represents the PH domain found in calcyphosin-2 proteins. The domain is found N-terminal to an EF-hand calcium-binding domain ( ). Calcium binding signalling proteins are characterised by their ability to bind calcium, which suggests a role in cellular signalling events. While some members are hypothesised t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25348"
] | [
"PH_CAYP2"
] | [
422
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160501"
] | [
"22375103"
] | [
"Evolution and functional diversity of the Calcium Binding Proteins (CaBPs)."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
422
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4
] | 3 | true | Domain | Calcyphosin-2, PH domain | Calcyphosin-2, PH domain | CAYP2_PH | 5 |
IPR057463 | 57,463 | CBASS inhibitor Acb3 | Acb3 | Family | 45 | false | false | This entry represents the Acb3 family of phage proteins that inhibit bacterial CBASS defence systems. Acb3 wraps around the CD-NTase enzyme and makes extensive contact with both the nucleotidyltransferase active site and ligand binding domain. Despite low sequence similarity between different CD-NTases, Acb3 can inhibi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25187"
] | [
"Acb3"
] | [
45
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Sphagnum jensenii"
] | [
27,
17,
1
] | 3 | [] | [] | 0 | true | Family | CBASS inhibitor Acb3 | CBASS inhibitor Acb3 | Acb3 | 1 |
IPR057465 | 57,465 | Ceramide kinase, PH domain | CERK_PH | Domain | 2,311 | false | false | This entry represents the PH domain found at the N-terminal of ceramide kinases in animals. The presence of this domain in ceramide kinases suggests a role in membrane localisation where their lipid substrates are found. The Ceramide kinase proteins are responsible for the phosphorylation of ceramide to produce ceramid... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25382"
] | [
"PH_CERK"
] | [
2311
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9840309",
"R-MMU-9840309"
] | [
"REACTOME:R-HSA-9840309",
"REACTOME:R-MMU-9840309"
] | 2 | [] | 0 | [
"PUB00003918",
"PUB00014130",
"PUB00057292",
"PUB00057293",
"PUB00080401",
"PUB00080402",
"PUB00098747",
"PUB00098753"
] | [
"7634082",
"14594214",
"8074669",
"7522330",
"22728242",
"17233582",
"29269995",
"21483860"
] | [
"More meanders and sandwiches.",
"Membrane targeting by pleckstrin homology domains.",
"Binding of PH domains of beta-adrenergic receptor kinase and beta-spectrin to WD40/beta-transducin repeat containing regions of the beta-subunit of trimeric G-proteins.",
"The pleckstrin homology domain of Bruton tyrosine ... | [
1994,
2004,
1994,
1994,
2012,
2007,
2017,
2011
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
2310,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
9,
4
] | 4 | true | Domain | Ceramide kinase, PH domain | Ceramide kinase, PH domain | CERK_PH | 1 |
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