interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR057834 | 57,834 | EBNA2, N-terminal domain | EBNA2_N | Domain | 238 | false | false | This entry represents the N-terminal dimerisation domain in EBNA2. This domain (also known as END domain) forms a novel dimeric fold comprising four β-strands and a short exposed α-helix. The dimer is stabilised by anti-parallel interactions of β-strands, forming a strong hydrophobic interface. EBNA2 is a key regulator... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25697"
] | [
"EBNA2_N"
] | [
238
] | 1 | [] | [] | [] | 0 | [
"2n2j"
] | 1 | [
"PUB00155752",
"PUB00160609",
"PUB00160610",
"PUB00160611"
] | [
"26845565",
"26024477",
"19126642",
"28968461"
] | [
"BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2.",
"The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation.",
"Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability.",
"EBF1 binds to EBNA2 and promot... | [
2016,
2015,
2009,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Lymphocryptovirus"
] | [
238
] | 1 | [] | [] | 0 | true | Domain | EBNA2, N-terminal domain | EBNA2, N-terminal domain | EBNA2_N | 7 |
IPR057836 | 57,836 | SWAP70, N-terminal EF-hand domain | EF-hand_SWAP70_N | Domain | 3,030 | false | false | This predicted EF-hand domain is found at the N-terminal end of SWAP70 and similar proteins mainly found in animals. SWAP-70 (also called Differentially expressed in FDCP 6/DEF-6 or IRF4-binding protein) functions in cellular signal transduction pathways (in conjunction with Rac), regulates cell motility through actin ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25530"
] | [
"EF-hand_SWAP70_N"
] | [
3030
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-8980692",
"R-DRE-9013148",
"R-DRE-9013149",
"R-DRE-9013404",
"R-HSA-8980692",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013423",
"R-MMU-8980692",
"R-MMU-9013148",
"R-MMU-9013149",
"R-MMU-9013404",
"R-MMU-9013423"
] | [
"REACTOME:R-DRE-8980692",
"REACTOME:R-DRE-9013148",
"REACTOME:R-DRE-9013149",
"REACTOME:R-DRE-9013404",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013423",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013148",
"REACTOM... | 14 | [] | 0 | [
"PUB00113074",
"PUB00113088",
"PUB00113089"
] | [
"22247562",
"21360565",
"21421853"
] | [
"Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain.",
"SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer.",
"Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP... | [
2012,
2011,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3030
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
9,
6,
9
] | 4 | true | Domain | SWAP70, N-terminal EF-hand domain | SWAP70, N-terminal EF-hand domain | EF-hand_SWAP70_N | 1 |
IPR057837 | 57,837 | SWAP70, PH domain | PH_SWAP70 | Domain | 2,829 | false | false | This entry represents the PH domain in SWAP-70 proteins and related eukaryotic proteins. SWAP-70 (also called Differentially expressed in FDCP 6/DEF-6 or IRF4-binding protein) functions in cellular signal transduction pathways (in conjunction with Rac), regulates cell motility through actin rearrangement, and contribut... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd13273"
] | [
"PH_SWAP-70"
] | [
2829
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-8980692",
"R-DRE-9013148",
"R-DRE-9013149",
"R-DRE-9013404",
"R-HSA-8980692",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013423",
"R-MMU-8980692",
"R-MMU-9013148",
"R-MMU-9013149",
"R-MMU-9013404",
"R-MMU-9013423"
] | [
"REACTOME:R-DRE-8980692",
"REACTOME:R-DRE-9013148",
"REACTOME:R-DRE-9013149",
"REACTOME:R-DRE-9013404",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013423",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013148",
"REACTOM... | 14 | [
"2dn6"
] | 1 | [
"PUB00014130",
"PUB00080401",
"PUB00080402",
"PUB00080403",
"PUB00080404",
"PUB00113074",
"PUB00113075",
"PUB00113076",
"PUB00113081",
"PUB00113082",
"PUB00113088",
"PUB00113089"
] | [
"14594214",
"22728242",
"17233582",
"15766521",
"15493994",
"22247562",
"21880631",
"22142166",
"22499172",
"21875669",
"21360565",
"21421853"
] | [
"Membrane targeting by pleckstrin homology domains.",
"Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.",
"Pleckstrin homology (PH) domains and phosphoinositides.",
"Pleckstrin homology domains: two halves make a hole?",
"Pleckstrin homology domains: not ju... | [
2004,
2012,
2007,
2005,
2004,
2012,
2011,
2012,
2012,
2011,
2011,
2011
] | 12 | [
"IPR001849"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
2829
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
8,
4,
8
] | 4 | true | Domain | SWAP70, PH domain | SWAP70, PH domain | PH_SWAP70 | 5 |
IPR057840 | 57,840 | FimV, N-terminal domain | FimV_N | Domain | 4,747 | false | false | This entry represents the N-terminal domain of the motility hub protein FimV that is located N-terminal to the LysM domain ( ). This domain adopts an immunoglobulin (Ig)-fold structure and is likely involved in interactions with other proteins and might contribute to the localisation of components of the type IV pilus ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25800"
] | [
"FimV_N"
] | [
4747
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045459",
"PUB00160617"
] | [
"10846211",
"21527471"
] | [
"Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa.",
"Role of fimV in type II secretion system-dependent protein secretion of Pseudomonas aeruginosa on solid medium."
] | [
2000,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"unclassified sequences"
] | [
7,
4666,
74
] | 3 | [] | [] | 0 | true | Domain | FimV, N-terminal domain | FimV, N-terminal domain | FimV_N | 1 |
IPR057841 | 57,841 | SORL1, Fn3 domain | FN3_SORL1 | Domain | 1,791 | false | false | This Fn3 domain is found towards the C-terminal of human Sortilin-related receptor (SORL1). SORL1 is a multifunctional sorting receptor involved in the intracellular trafficking and localisation of various protein cargoes. It cooperates with the AP-1 complex in Golgi-endosome sorting pathways [ ] and regulates the traf... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25814"
] | [
"fn3_SORL1"
] | [
1791
] | 1 | [
"REACTOME"
] | [
"R-HSA-977225"
] | [
"REACTOME:R-HSA-977225"
] | 1 | [] | 0 | [
"PUB00140409",
"PUB00145449",
"PUB00158047",
"PUB00158048",
"PUB00160618",
"PUB00160834",
"PUB00160835",
"PUB00160836",
"PUB00160837",
"PUB00160838",
"PUB00160839",
"PUB00160840",
"PUB00160841",
"PUB00160842",
"PUB00160843",
"PUB00160844",
"PUB00160845",
"PUB00160846",
"PUB001608... | [
"25385546",
"25908590",
"23486467",
"14764453",
"32355037",
"16174740",
"16407538",
"17646382",
"17855360",
"18603531",
"21385844",
"21994944",
"23333276",
"23977241",
"24523320",
"26858303",
"27322061",
"28265003",
"31138794"
] | [
"Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.",
"Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation.",
"The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen acti... | [
2014,
2015,
2013,
2004,
2020,
2005,
2006,
2007,
2007,
2008,
2011,
2011,
2013,
2013,
2014,
2016,
2016,
2017,
2019
] | 19 | [
"IPR003961"
] | [] | 1 | 0 | 1 | [
"Bilateria",
"Lachnospiraceae"
] | [
1784,
7
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
9,
2,
2
] | 4 | true | Domain | SORL1, Fn3 domain | SORL1, Fn3 domain | FN3_SORL1 | 5 |
IPR057842 | 57,842 | MER3 helicase-like, winged helix domain | WH_MER3 | Domain | 14,388 | false | false | This entry represents a winged Helix-Turn-Helix domain found in a variety of helicase enzymes, including ATP-dependent DNA helicase MER3, U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200), Pre-mRNA-splicing helicase BRR2 and RQC trigger complex helicase SLH1. SNRNP200 catalyses the ATP-dependent unwinding ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23445"
] | [
"WHD_SNRNP200"
] | [
14388
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72163",
"R-CEL-72165",
"R-DDI-72163",
"R-DME-72163",
"R-DME-72165",
"R-HSA-112126",
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165",
"R-RNO-72163",
"R-RNO-72165",
"R-SPO-72163"
] | [
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-72165",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-72163",
"REACTOME:R-DME-72165",
"REACTOME:R-HSA-112126",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165",
"REACTOME:R-RNO-72163",
"REACTOME:R-RNO-72165",
"RE... | 13 | [
"3jcm",
"3jcr",
"4bgd",
"4f91",
"4f92",
"4f93",
"4kit",
"5dca",
"5gan",
"5gao",
"5gap",
"5gm6",
"5lj5",
"5lqw",
"5m52",
"5m59",
"5m5p",
"5nrl",
"5o9z",
"5urj",
"5urk",
"5urm",
"5xjc",
"5yzg",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ff7"... | 102 | [
"PUB00062592",
"PUB00090272",
"PUB00092514",
"PUB00094479",
"PUB00094506",
"PUB00099554",
"PUB00100665",
"PUB00100666",
"PUB00101521",
"PUB00101900",
"PUB00151147",
"PUB00155046",
"PUB00155725",
"PUB00155845",
"PUB00155846",
"PUB00160848",
"PUB00160849"
] | [
"23045696",
"28781166",
"28502770",
"29301961",
"29360106",
"32203490",
"26912367",
"26743623",
"28223409",
"35241646",
"30893611",
"19098916",
"28757607",
"23727230",
"23704370",
"23124065",
"10922069"
] | [
"Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.",
"Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.",
"An Atomic Structure of the Human Spliceosome.",
"Structure of a human catalytic step I spliceosome.... | [
2012,
2017,
2017,
2018,
2018,
2020,
2016,
2016,
2017,
2022,
2019,
2009,
2017,
2013,
2013,
2012,
2000
] | 17 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Stenosarchaea group",
"marine sediment metagenome"
] | [
14052,
335,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
22,
4,
28,
3,
17,
4,
3,
13,
12,
3,
2,
36
] | 12 | true | Domain | MER3 helicase-like, winged helix domain | MER3 helicase-like, winged helix domain | WH_MER3 | 3 |
IPR057843 | 57,843 | Fusellovirus capsid protein VP2 | Fusello_VP2 | Family | 17 | false | false | The Fusellovirus capsid protein VP2 family is characterised by its role in binding to DNA, which is crucial for the function of the SSV1 virus. This protein is highly basic, suggesting a strong affinity for the negatively charged DNA. The interaction between the Capsid protein VP2 and the viral DNA is essential for the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25632"
] | [
"Fusello_VP2_Capsid"
] | [
17
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Thermus",
"Viruses"
] | [
6,
5,
6
] | 3 | [] | [] | 0 | true | Family | Fusellovirus capsid protein VP2 | Fusellovirus capsid protein VP2 | Fusello_VP2 | 7 |
IPR057844 | 57,844 | Putative filamentous viruses peptidase | FV_peptidase | Family | 3 | false | false | This entry represents a family of uncharacterised proteins from archaeal filamentous viruses including HAV1, PFV1 and PFV2, and TTV1. Structure predictions show similarity to viral peptidase proteins, suggesting this is a virus-processing peptidase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25658"
] | [
"FV_peptidase"
] | [
3
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tristromaviridae"
] | [
3
] | 1 | [] | [] | 0 | true | Family | Putative filamentous viruses peptidase | Putative filamentous viruses peptidase | FV_peptidase | 4 |
IPR057845 | 57,845 | Gabija anti-defense 1 | Gad1 | Family | 30 | false | false | This entry represents the Gabija anti-defense 1 (Gad1) protein family, which is encoded by bacteriophages to counteract the bacterial Gabija anti-phage defence system. Gad1 forms an octameric web that encases the Gabija GajAB complex, blocking its ability to bind and cleave phage DNA. The relatively large size of Gad1 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25705"
] | [
"Gad1"
] | [
30
] | 1 | [] | [] | [] | 0 | [
"8u7i"
] | 1 | [
"PUB00153732",
"PUB00160619"
] | [
"37992756",
"37992757"
] | [
"Phages overcome bacterial immunity via diverse anti-defence proteins.",
"Structural basis of Gabija anti-phage defence and viral immune evasion."
] | [
2024,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"marine sediment metagenome"
] | [
25,
2,
3
] | 3 | [] | [] | 0 | true | Family | Gabija anti-defense 1 | Gabija anti-defense 1 | Gad1 | 4 |
IPR057846 | 57,846 | Calcineurin domain containing, winged helix-turn-helix domain | wHTH-Calcineurin_assc | Domain | 61 | false | false | This entry represents a wHTH domain found at the C-terminal end of proteins containing Calcineurin-CE (covered by ), in antiviral immunity systems containing an ORC/CDC6 like AAA+ ATPase ( ) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24408"
] | [
"wHTH-Calcineurin_assc"
] | [
61
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
61
] | 1 | [] | [] | 0 | true | Domain | Calcineurin domain containing, winged helix-turn-helix domain | Calcineurin domain containing, winged helix-turn-helix domain | wHTH-Calcineurin_assc | 2 |
IPR057847 | 57,847 | ZMIZ1/ZMIZ2, GBD-like domain | ZMIZ1/ZMIZ2_GBD-like | Domain | 4,440 | false | false | This domain is found in the human Zinc finger MIZ domain-containing protein 1/2 (ZMIZ1 and ZMIZ2) and related proteins. This domain is predicted to fold into a β-sandwich with a topology typical for galactose-binding domains. It is closely related to . It is frequently found in combination with . ZMIZ1 is a transcripti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25527"
] | [
"GBD-like_ZMIZ1_ZMIZ2"
] | [
4440
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091269",
"PUB00136447",
"PUB00136450"
] | [
"26522984",
"14609956",
"16777850"
] | [
"The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.",
"hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.",
"The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity."
] | [
2015,
2003,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4440
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
5,
6,
2,
10
] | 5 | true | Domain | ZMIZ1/ZMIZ2, GBD-like domain | ZMIZ1/ZMIZ2, GBD-like domain | ZMIZ1/ZMIZ2_GBD-like | 6 |
IPR057848 | 57,848 | WDR72-like, alpha-solenoid domain | WDR72_alpha-sol | Domain | 1,599 | false | false | This entry represents an α-solenoid domain found in WDR72. This entry also includes WDR7, whose function is currently unknown. WD repeat-containing protein 72 (WDR72) plays a major role in the formation of tooth enamel, particularly during the maturation phase of amelogenesis, where it is essential for normal enamel ma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23123"
] | [
"WDR72_alpha-sol"
] | [
1599
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153333",
"PUB00153334"
] | [
"19853237",
"25008349"
] | [
"Mutations in the beta propeller WDR72 cause autosomal-recessive hypomaturation amelogenesis imperfecta.",
"WDR72 models of structure and function: a stage-specific regulator of enamel mineralization."
] | [
2009,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1599
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
6
] | 3 | true | Domain | WDR72-like, alpha-solenoid domain | WDR72-like, alpha-solenoid domain | WDR72_alpha-sol | 6 |
IPR057850 | 57,850 | Gp11, C-terminal domain | Gp11_C | Domain | 158 | false | false | This entry represents the C-terminal β-barrel domain found in the Phage Mu Gp11 protein. The function of this protein is not known. In some proteins, this domain covers the whole sequence. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25754"
] | [
"Gp11_C"
] | [
158
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Enterobacterales"
] | [
4,
154
] | 2 | [] | [] | 0 | true | Domain | Gp11, C-terminal domain | Gp11, C-terminal domain | Gp11_C | 8 |
IPR057851 | 57,851 | ATXR3, GYF domain | ATXR3_GYF | Domain | 797 | false | false | This entry represents the presumed GYF domain in ATXR3 from Arabidopsis thaliana. This domain, which is usually associated with and , is predicted to adopt an α-β configuration. Histone-lysine N-methyltransferase (ATXR3), also known as SET DOMAIN GROUP 2 (SDG2), is involved in the trimethylation of lysine 4 on histone ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25531"
] | [
"GYF_ATXR3"
] | [
797
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085380",
"PUB00085381",
"PUB00160850"
] | [
"21037105",
"20937886",
"31429787"
] | [
"Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and is crucial for both sporophyte and gametophyte development.",
"SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis.",
"Diurnal regulation of SDG2 and JMJ14 by circadian clock oscillators orchest... | [
2010,
2010,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Rubritalea squalenifaciens DSM 18772"
] | [
796,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
1,
62
] | 3 | true | Domain | ATXR3, GYF domain | ATXR3, GYF domain | ATXR3_GYF | 5 |
IPR057852 | 57,852 | WDR11, first beta-propeller | Beta-prop_WDR11_1st | Domain | 2,318 | false | false | This entry represents the first β-propeller found at the N-terminal end of WD repeat-containing protein 11 (WDR11) from animals and similar eukaryotic proteins. Members of the WDR11 family share a domain architecture consisting of two β-propellers followed by a TPR domain. WDR11 has been implicated in human development... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23751"
] | [
"Beta-prop_WDR11_1st"
] | [
2318
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013407",
"R-MMU-9013407"
] | [
"REACTOME:R-HSA-9013407",
"REACTOME:R-MMU-9013407"
] | 2 | [
"8xfb",
"8z9m"
] | 2 | [
"PUB00089990",
"PUB00089991",
"PUB00090056",
"PUB00155546"
] | [
"29426865",
"29263200",
"29084197",
"20887964"
] | [
"The WDR11 complex facilitates the tethering of AP-1-derived vesicles.",
"WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.",
"TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.",
"WDR11, a WD protein that interacts with t... | [
2018,
2018,
2017,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gimesia maris"
] | [
2316,
2
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
2,
2,
4,
2,
2,
13
] | 7 | true | Domain | WDR11, first beta-propeller | WDR11, first beta-propeller | Beta-prop_WDR11_1st | 9 |
IPR057853 | 57,853 | WDR11, second beta-propeller | Beta-prop_WDR11_2nd | Domain | 2,411 | false | false | This entry represents the second β-propeller found in WD repeat-containing protein 11 (WDR11) from animals and similar eukaryotic proteins. Members of the WDR11 family share a domain architecture consisting of two β-propellers followed by a TPR domain. WDR11 has been implicated in human developmental genetic disorders ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23752"
] | [
"Beta-prop_WDR11_2nd"
] | [
2411
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013407",
"R-MMU-9013407"
] | [
"REACTOME:R-HSA-9013407",
"REACTOME:R-MMU-9013407"
] | 2 | [
"8xfb",
"8z9m"
] | 2 | [
"PUB00089990",
"PUB00089991",
"PUB00090056",
"PUB00155546"
] | [
"29426865",
"29263200",
"29084197",
"20887964"
] | [
"The WDR11 complex facilitates the tethering of AP-1-derived vesicles.",
"WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.",
"TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.",
"WDR11, a WD protein that interacts with t... | [
2018,
2018,
2017,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2411
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
2,
2,
5,
2,
4,
3,
12
] | 8 | true | Domain | WDR11, second beta-propeller | WDR11, second beta-propeller | Beta-prop_WDR11_2nd | 1 |
IPR057854 | 57,854 | WDR11, TPR domain | TPR_WDR11 | Domain | 2,362 | false | false | This entry represents the TPR domain found at the C-terminal of WD repeat-containing protein 11 (WDR11) from animals and similar eukaryotic proteins. Members of the WDR11 family share a domain architecture consisting of two β-propellers followed by a TPR domain. WDR11 has been implicated in human developmental genetic ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23753"
] | [
"TPR_WDR11"
] | [
2362
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013407",
"R-MMU-9013407"
] | [
"REACTOME:R-HSA-9013407",
"REACTOME:R-MMU-9013407"
] | 2 | [
"8xfb",
"8z9m"
] | 2 | [
"PUB00089990",
"PUB00089991",
"PUB00090056",
"PUB00155546"
] | [
"29426865",
"29263200",
"29084197",
"20887964"
] | [
"The WDR11 complex facilitates the tethering of AP-1-derived vesicles.",
"WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.",
"TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.",
"WDR11, a WD protein that interacts with t... | [
2018,
2018,
2017,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2362
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
2,
6,
2,
4,
3,
11
] | 7 | true | Domain | WDR11, TPR domain | WDR11, TPR domain | TPR_WDR11 | 2 |
IPR057855 | 57,855 | WDR19, first beta-propeller | Beta-prop_WDR19_1st | Domain | 2,845 | false | false | This entry represents the first β-propeller of WRD19 (also known as IFT144) from animals and the orthologue from C.elegans DYF2. This domain is also found in the WD repeat-containing protein 39-A/B from Salmo salar. WDR19 is a core component of the IFT complex A (IFT-A, together with IFT140 and IFT122), a complex requi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23389"
] | [
"Beta-prop_WDR19_1st"
] | [
2845
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5610787",
"R-CEL-5620924",
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924"
] | [
"REACTOME:R-CEL-5610787",
"REACTOME:R-CEL-5620924",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924"
] | 6 | [
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hme",
"8hmf",
"8ruy"
] | 10 | [
"PUB00089704",
"PUB00155528"
] | [
"20889716",
"36462505"
] | [
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"IFT-A structure reveals carriages for membrane protein transport into cilia."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Fervidicoccus fontis",
"ecological metagenomes"
] | [
107,
2735,
1,
2
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
8,
2,
3
] | 6 | true | Domain | WDR19, first beta-propeller | WDR19, first beta-propeller | Beta-prop_WDR19_1st | 5 |
IPR057856 | 57,856 | VWC2L, C-terminal domain | VWC2L_C | Domain | 1,842 | false | false | This domain is found at the C-terminal end of human von Willebrand factor C domain-containing protein 2-like (VWC2L), its paralogue von Willebrand factor C domain-containing protein 2 (Brorin), encoded by gene VWC2 and similar proteins predominantly found in vertebrates. VWC2L may play a role in neurogenesis, bone diff... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23331"
] | [
"VWC2L_C"
] | [
1842
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071682",
"PUB00071683"
] | [
"17400546",
"19852960"
] | [
"Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells.",
"A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
] | [
2007,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1842
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2,
5
] | 4 | true | Domain | VWC2L, C-terminal domain | VWC2L, C-terminal domain | VWC2L_C | 5 |
IPR057857 | 57,857 | UL116 | HCMV_UL116 | Family | 87 | false | false | This entry represents the human cytomegalovirus (HCMV) UL116 protein, which forms a complex with glycoprotein H (gH) independently from glycoprotein L (gL). UL116 acts as a chaperone for gH and promotes the expression of gH/gL complexes and is required for efficient production of infectious cell-free virions. UL116 int... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25706"
] | [
"HCMV_UL116"
] | [
87
] | 1 | [] | [] | [] | 0 | [
"9dix",
"9diy"
] | 2 | [
"PUB00160621",
"PUB00160622",
"PUB00160623",
"PUB00160624"
] | [
"39416215",
"26937030",
"33889136",
"34011552"
] | [
"A noncanonical glycoprotein H complex enhances cytomegalovirus entry.",
"The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL.",
"The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions.",
"Th... | [
2024,
2016,
2021,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Adineta steineri",
"Cytomegalovirus"
] | [
1,
86
] | 2 | [] | [] | 0 | true | Family | UL116 | UL116 | HCMV_UL116 | 8 |
IPR057858 | 57,858 | UL15A | HCMV_UL15A | Family | 34 | false | false | This entry represents the Human cytomegalovirus (HCMV) UL15A protein family. UL15A is a small single-pass membrane protein found in betaherpesviruses. The protein contains an extracellular N-terminal domain, a transmembrane helix, and a short cytoplasmic C-terminal domain. The N-terminal region is largely disordered an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25739"
] | [
"HCMV_UL15A"
] | [
34
] | 1 | [
"REACTOME"
] | [
"R-HSA-9610379"
] | [
"REACTOME:R-HSA-9610379"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cytomegalovirus"
] | [
34
] | 1 | [] | [] | 0 | true | Family | UL15A | UL15A | HCMV_UL15A | 7 |
IPR057859 | 57,859 | HFD-like domain | HFD | Domain | 20 | false | false | This entry represents the C-terminal domain of the head fibre dimeric protein (HFD) found in crassviruses from the order Crassvirales. This entry also contains a small number of other non-phage proteins that share this domain; in these proteins, this domain is not at the C-terminal. In the crAss001 virus, this protein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25641"
] | [
"Head_fiber_dimeric"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"7qof",
"8ckb"
] | 2 | [
"PUB00155591"
] | [
"37138077"
] | [
"Structural atlas of a human gut crassvirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Pseudomonadati"
] | [
7,
13
] | 2 | [] | [] | 0 | true | Domain | HFD-like domain | HFD-like domain | HFD | 8 |
IPR057860 | 57,860 | RRP12, N-terminal HEAT domain | HEAT_RRP12_N | Domain | 5,065 | false | false | This entry represents the N-terminal region of human RRP12-like protein, which consists of HEAT repeats. This domain is often found associated with . Ribosomal RNA-processing protein 12 (RRP12) proteins are members of pre-ribosome-associated HEAT repeats-containing proteins [ , , ]. They are involved in the maturation ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25772"
] | [
"HEAT_RRP12_N"
] | [
5065
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SPO-6798695",
"R-SPO-8951664",
"R-SPO-917937"
] | [
"REACTOME:R-SPO-6798695",
"REACTOME:R-SPO-8951664",
"REACTOME:R-SPO-917937"
] | 3 | [
"7wts",
"7wtt",
"7wtu",
"7wtv",
"7wtw",
"7wtx",
"7wtz",
"7wu0"
] | 8 | [
"PUB00016366",
"PUB00101821",
"PUB00101822",
"PUB00160625"
] | [
"15112237",
"14729571",
"29875412",
"36321656"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.",
"Visualizing late states of human 40S ribosomal subunit maturation.",
"The nucleoplasmic phase of pre-40S formati... | [
2004,
2004,
2018,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5065
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
1,
4,
3,
2,
1,
5,
4,
1,
2,
15
] | 12 | true | Domain | RRP12, N-terminal HEAT domain | RRP12, N-terminal HEAT domain | HEAT_RRP12_N | 9 |
IPR057861 | 57,861 | BDLF2/ORF27-like | BDLF2/ORF27-like | Family | 122 | false | false | This entry represents a family of gamma-herpesvirus glycoproteins involved in intercellular viral spread. Members of this family include the BDLF2 protein from Epstein-Barr virus, ORF27 from Human herpesvirus 8 and VG27 from other herpesviruses. This glycoprotein forms a complex with another viral protein (ORF58/BMRF2)... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25730"
] | [
"Herpes_BDLF2"
] | [
122
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160626"
] | [
"18350146"
] | [
"A gamma-herpesvirus glycoprotein complex manipulates actin to promote viral spread."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Orthoherpesviridae"
] | [
122
] | 1 | [] | [] | 0 | true | Family | BDLF2/ORF27-like | BDLF2/ORF27-like | BDLF2/ORF27-like | 2 |
IPR057862 | 57,862 | Glycoprotein Q2/Q1/105 | Q2/Q1/105 | Domain | 44 | false | false | This entry represents the Glycoprotein Q1, Q2 and 105 of human herpesvirus-6 (HHV-6). Glycoprotein Q2 (gQ2) forms a tetrameric complex with glycoproteins gH, gL, and gQ1 that is essential for viral entry. In HHV-6A, this complex binds to the cellular receptor CD46, while in HHV-6B the complex has different receptor spe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25736"
] | [
"Herpes_gQ2"
] | [
44
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160627"
] | [
"24215487"
] | [
"Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Homo sapiens",
"Roseolovirus"
] | [
1,
43
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Domain | Glycoprotein Q2/Q1/105 | Glycoprotein Q2/Q1/105 | Q2/Q1/105 | 6 |
IPR057863 | 57,863 | ORF28, N-terminal domain | ORF28_N | Domain | 35 | false | false | This entry represents a conserved domain at the N-terminal in the uncharacterised protein ORF28 from Ictalurid herpesvirus 1. This domain contains conserved cysteine residues that may form a zinc-binding motif. The function of this domain remains unknown, but it is primarily found in herpesviruses that infect fish. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25720"
] | [
"Herpes_ORF28"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinopteri",
"Herpesvirales"
] | [
14,
21
] | 2 | [] | [] | 0 | true | Domain | ORF28, N-terminal domain | ORF28, N-terminal domain | ORF28_N | 2 |
IPR057864 | 57,864 | ORF30 | ORF30 | Family | 4 | false | false | This entry represents the Ictalurid herpesvirus (IcHV-1) uncharacterised protein ORF30. This protein contains a conserved CXXC motif (CPI) at positions 74-77, which may indicate a potential zinc-binding function. ORF30 is encoded by channel catfish virus, which is the type species of the Alloherpesviridae family, disti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25748"
] | [
"Herpes_ORF30"
] | [
4
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Herpesvirales"
] | [
4
] | 1 | [] | [] | 0 | true | Family | ORF30 | ORF30 | ORF30 | 6 |
IPR057865 | 57,865 | ORF32/34 | ORF32/34 | Domain | 47 | false | false | This entry represents the herpesvirus ORF32 phosphoprotein. It includes the phosphoprotein 32 from Varicella-zoster virus (HHV-3) and homologous proteins such as Gene 34 from Equine herpesvirus 1. The ORF32 protein is known to be phosphorylated by the ORF47 protein in Varicella-zoster virus. The function of this protei... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25717"
] | [
"Herpes_ORF32"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaherpesvirinae"
] | [
47
] | 1 | [] | [] | 0 | true | Domain | ORF32/34 | ORF32/34 | ORF32/34 | 7 |
IPR057866 | 57,866 | U21 glycoprotein | HHV_U21 | Family | 44 | false | false | This entry represents the U21 glycoprotein found in human herpesviruses. U21 is a viral membrane protein from betaherpesviruses, including human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7). U21 functions as an immunoevasin that plays a role in viral immune evasion by targeting multiple host proteins. It has b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25689"
] | [
"HHV_U21"
] | [
44
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045947",
"PUB00160628"
] | [
"17467766",
"34721381"
] | [
"Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules.",
"The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition."
] | [
2007,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Herpesvirales",
"Homo sapiens"
] | [
43,
1
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | U21 glycoprotein | U21 glycoprotein | HHV_U21 | 7 |
IPR057867 | 57,867 | Major capsid protein VP21 | VP21 | Family | 48 | false | false | This entry represents the major capsid protein (VP21) of His1 virus, a spindle-shaped virus that infects the extremely halophilic euryarchaeon Haloarcula hispanica. The His1 virion is composed of one major structural protein, VP21 and a few minor structural proteins. VP21 exists in two forms, with the higher molecular ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25665"
] | [
"His1_capsid"
] | [
48
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160629"
] | [
"23163639"
] | [
"Modified coat protein forms the flexible spindle-shaped virion of haloarchaeal virus His1."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"His1 virus (isolate Australia/Victoria)",
"Psychracetigena formicireducens",
"marine sediment metagenome"
] | [
2,
1,
1,
44
] | 4 | [] | [] | 0 | true | Family | Major capsid protein VP21 | Major capsid protein VP21 | VP21 | 4 |
IPR057868 | 57,868 | Hydroxymethylglutaryl-CoA reductase-like | HMG-CoA | Domain | 229 | false | false | This domain is found at the N-terminal end in Hydroxymethylglutaryl-CoA (HMG-CoA) reductase from Candidatus Promineifilum [ ]. This domain also covers the whole length of some HMG-CoA. This domain is predicted to adopt a mostly β configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25653"
] | [
"HMG-CoA_red_N"
] | [
229
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160630"
] | [
"39993224"
] | [
"Halophilic archaea produce wax esters and use an alternative fatty acyl-coenzyme A reductase for precursor synthesis."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Tanacetum cinerariifolium",
"ecological metagenomes"
] | [
33,
191,
2,
3
] | 4 | [] | [] | 0 | true | Domain | Hydroxymethylglutaryl-CoA reductase-like | Hydroxymethylglutaryl-CoA reductase-like | HMG-CoA | 6 |
IPR057869 | 57,869 | YO34 | HP1_YO34 | Family | 951 | false | false | This entry represents a family of phage proteins predicted to be involved in the sheath-tube baseplate complex such as uncharacterised protein YO34. Members of this family show structural similarity to the Pvc7 component of contractile injection systems , suggesting a likely structural role in the phage tail assembly. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25759"
] | [
"HP1_ORF34"
] | [
951
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
919,
2,
28,
2
] | 4 | [] | [] | 0 | true | Family | YO34 | YO34 | HP1_YO34 | 3 |
IPR057870 | 57,870 | TOCA, HR1 domain | HR1_TOCA | Domain | 9,253 | false | false | This entry represents the HR1 (homology region 1) domain found in TOCA proteins including TOCA1, CIP4, FBP1 and FBP17. This domain forms an antiparallel coiled-coil structure that mediates binding to the small GTPase Cdc42. Unlike other HR1 domains that bind to RhoA or Rac1 with high affinity, the TOCA family HR1 domai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25610"
] | [
"HR1_TOCA"
] | [
9253
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8856828",
"R-CEL-9013406",
"R-DRE-9013406",
"R-HSA-203641",
"R-HSA-8856828",
"R-HSA-9013148",
"R-HSA-9013406",
"R-HSA-9013409",
"R-HSA-9696270",
"R-MMU-203641",
"R-MMU-8856828",
"R-MMU-9013406",
"R-MMU-9696270",
"R-RNO-203641",
"R-RNO-8856828",
"R-RNO-9013406",
"R-RNO-9696270"... | [
"REACTOME:R-CEL-8856828",
"REACTOME:R-CEL-9013406",
"REACTOME:R-DRE-9013406",
"REACTOME:R-HSA-203641",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013409",
"REACTOME:R-HSA-9696270",
"REACTOME:R-MMU-203641",
"REACTOME:R-MMU-8856828",
"REACTOME:... | 17 | [
"2ke4",
"5frg"
] | 2 | [
"PUB00094802",
"PUB00128052",
"PUB00160851",
"PUB00160852"
] | [
"27129201",
"19387844",
"23150597",
"30456600"
] | [
"Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.",
"The NMR structure of the TC10- and Cdc42-interacting domain of CIP4.",
"toca-1 is in a novel pathway that functions in parallel with a SUN... | [
2016,
2009,
2013,
2018
] | 4 | [
"IPR011072"
] | [
"IPR057871"
] | 1 | 1 | 0 | [
"Eukaryota"
] | [
9253
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
63,
14,
23,
16,
26
] | 6 | true | Domain | TOCA, HR1 domain | TOCA, HR1 domain | HR1_TOCA | 8 |
IPR057871 | 57,871 | FNBP1L/CIP4, HR1 domain | HR1_CIP4_FNBP1L | Domain | 2,973 | false | false | This entry represents the HR1 domain in FBP1L and CIP4 proteins which are a subset of TOCA proteins. CIP4 and FNBP1L are Cdc42 effectors that bind Wiskott-Aldrich syndrome protein (WASP) and function in endocytosis. Formin-binding protein 1-like (FNBP1L, also known as Toca-1) is part of the Toca-1-N-WASP complex that i... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd11628"
] | [
"HR1_CIP4_FNBP1L"
] | [
2973
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-9013406",
"R-HSA-8856828",
"R-HSA-9013148",
"R-HSA-9013406",
"R-HSA-9013409",
"R-MMU-8856828",
"R-MMU-9013406",
"R-RNO-8856828",
"R-RNO-9013406"
] | [
"REACTOME:R-DRE-9013406",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013409",
"REACTOME:R-MMU-8856828",
"REACTOME:R-MMU-9013406",
"REACTOME:R-RNO-8856828",
"REACTOME:R-RNO-9013406"
] | 9 | [
"5frg"
] | 1 | [
"PUB00071689",
"PUB00071690",
"PUB00072643",
"PUB00112525",
"PUB00112537",
"PUB00123165",
"PUB00123166",
"PUB00123167",
"PUB00123168",
"PUB00123169",
"PUB00127711",
"PUB00128052",
"PUB00128053"
] | [
"19213734",
"23384583",
"20730103",
"15260983",
"19909236",
"19342671",
"18191793",
"16885158",
"14654988",
"15260990",
"20940394",
"19387844",
"19798448"
] | [
"The Toca-1-N-WASP complex links filopodial formation to endocytosis.",
"Biochemical and functional significance of F-BAR domain proteins interaction with WASP/N-WASP.",
"Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis.... | [
2009,
2013,
2010,
2004,
2010,
2009,
2008,
2006,
2004,
2004,
2010,
2009,
2009
] | 13 | [
"IPR057870"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
2973
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
9,
6,
12
] | 4 | true | Domain | FNBP1L/CIP4, HR1 domain | FNBP1L/CIP4, HR1 domain | HR1_CIP4_FNBP1L | 5 |
IPR057872 | 57,872 | Derepression protein | Derepression | Family | 318 | false | false | The Derepression protein family is involved in the induction of the P2 prophage helper by P4. This process is essential for the derepression mechanism, which allows the prophage to become active under certain conditions. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25738"
] | [
"Derepression"
] | [
318
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aphis craccivora",
"Caudoviricetes",
"Enterobacterales"
] | [
1,
3,
314
] | 3 | [] | [] | 0 | true | Family | Derepression protein | Derepression protein | Derepression | 8 |
IPR057875 | 57,875 | Tail hub protein B | crAss_THB | Family | 18 | false | false | This entry represents the tail hub protein B (THB) found in bacteriophages. The protein forms a heterotrimer with tail hub protein A (THA), and these heterotrimers further assemble as 12 docking hubs that form a continuous collar around the tail barrel. The C-terminal segment of THB (residues 67-107) extends into the n... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25711"
] | [
"crAss_THB"
] | [
18
] | 1 | [] | [] | [] | 0 | [
"7qoj",
"7qol",
"8ckb"
] | 3 | [
"PUB00155591"
] | [
"37138077"
] | [
"Structural atlas of a human gut crassvirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes"
] | [
18
] | 1 | [] | [] | 0 | true | Family | Tail hub protein B | Tail hub protein B | crAss_THB | 8 |
IPR057876 | 57,876 | Tail hub protein A | crAss_THA | Family | 20 | false | false | This entry represents the tail hub protein A (THA) found in bacteriophages. The protein forms a heterotrimer with tail hub protein B (THB), with each assembly consisting of two copies of THA and one copy of THB ( ). These heterotrimers further assemble as 12 docking hubs that form a continuous collar around the tail ba... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25724"
] | [
"crAss_THA"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"7qoj",
"7qol",
"8ckb"
] | 3 | [
"PUB00155591"
] | [
"37138077"
] | [
"Structural atlas of a human gut crassvirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Caudoviricetes"
] | [
20
] | 1 | [] | [] | 0 | true | Family | Tail hub protein A | Tail hub protein A | crAss_THA | 7 |
IPR057877 | 57,877 | Phage tail ring protein 3/4 | CrAss_Ring_3_4 | Family | 46 | false | false | This entry represents the Ring 3 and 4/5 proteins, which are part of the tail assembly in crassviruses. These proteins forms two of five stacked dodecameric rings that make up the tail barrel. These proteins share a conserved fold consisting of two domains: an α-helical domain and a β-sandwich domain. The extended tail... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25710"
] | [
"CrAss_Ring_3_4"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"7qoj",
"7qok",
"7qol",
"8ckb"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"marine sediment metagenome"
] | [
45,
1
] | 2 | [] | [] | 0 | true | Family | Phage tail ring protein 3/4 | Phage tail ring protein 3/4 | CrAss_Ring_3_4 | 1 |
IPR057880 | 57,880 | Inhibitor of histone-like protein HU | HU_inhibitor | Family | 11 | false | false | This entry represents a bacteriophage protein that acts as an inhibitor of bacterial histone-like protein HU. The protein binds to HU, occupying its DNA binding motif and preventing HU-DNA complex formation. This inhibition leads to defects in chromosome segregation and causes filamentous cell morphology in bacteria. T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25723"
] | [
"HU_inhibitor"
] | [
11
] | 1 | [] | [] | [] | 0 | [
"7by7"
] | 1 | [
"PUB00160631"
] | [
"35193978"
] | [
"Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Herelleviridae"
] | [
11
] | 1 | [] | [] | 0 | true | Family | Inhibitor of histone-like protein HU | Inhibitor of histone-like protein HU | HU_inhibitor | 5 |
IPR057881 | 57,881 | Little elongation complex subunit 1, C-terminal domain | ICE1_C | Domain | 1,136 | false | false | This domain is found at the C-terminal end of ICE1 mainly in animals. This domain is predicted to adopt an all-α configuration. Little elongation complex subunit 1 (ICE1) acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at small nuclear RNA (snRNA) genes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25817"
] | [
"ICE1_C"
] | [
1136
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1136
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
4,
3
] | 4 | true | Domain | Little elongation complex subunit 1, C-terminal domain | Little elongation complex subunit 1, C-terminal domain | ICE1_C | 7 |
IPR057882 | 57,882 | Cytosolic endo-beta-N-acetylglucosaminidase, C-terminal domain | ENGase_C | Domain | 1,508 | false | false | This domain is found at the C-terminal in ENGase found in plants and vertebrates. This domain is predicted to adopt an immunoglobulin (Ig)-like fold. Endo-β-N-acetylglucosaminidase (ENGase) is a glycosyl hydrolase that cleaves the β-1,4-glycosidic bond within the di-N-acetylchitobiose core of N-glycosylated proteins, l... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25529"
] | [
"Ig_ENGASE1_C"
] | [
1508
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.96",
"R-DRE-532668",
"R-HSA-532668",
"R-MMU-532668"
] | [
"EC:3.2.1.96",
"REACTOME:R-DRE-532668",
"REACTOME:R-HSA-532668",
"REACTOME:R-MMU-532668"
] | 4 | [] | 0 | [
"PUB00004870",
"PUB00005266",
"PUB00160853"
] | [
"7624375",
"8535779",
"1233211"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"The measurement of drug consumption. Drugs for diabetes in Northern Ireland, Norway and Sweden."
] | [
1995,
1995,
1975
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1508
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
1,
1,
3,
3,
2,
5
] | 7 | true | Domain | Cytosolic endo-beta-N-acetylglucosaminidase, C-terminal domain | Cytosolic endo-beta-N-acetylglucosaminidase, C-terminal domain | ENGase_C | 7 |
IPR057884 | 57,884 | RIMS-binding protein 1/2/3, Fn3 domain | FN3_RIM-BP1/2/3 | Domain | 5,742 | false | false | This immunoglobulin (Ig)-like domain is found in RIMS-binding protein 1, 2, 3 and similar proteins, mainly found in animals. It has a similar fold to Fibronectin type III (Fn3) ( ). RIMs binding proteins (RBPs, RIM-BPs) associate with calcium channels present in photoreceptors, neurons, and hair cells; they interact si... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25523"
] | [
"Ig_RIMBP2"
] | [
5742
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-181429",
"R-HSA-181430",
"R-HSA-196108",
"R-HSA-210500",
"R-HSA-212676",
"R-HSA-264642",
"R-MMU-181429",
"R-MMU-181430",
"R-MMU-196108",
"R-MMU-210500",
"R-MMU-212676",
"R-MMU-264642",
"R-RNO-181429",
"R-RNO-181430",
"R-RNO-196108",
"R-RNO-210500",
"R-RNO-212676",
"R-RNO-264... | [
"REACTOME:R-HSA-181429",
"REACTOME:R-HSA-181430",
"REACTOME:R-HSA-196108",
"REACTOME:R-HSA-210500",
"REACTOME:R-HSA-212676",
"REACTOME:R-HSA-264642",
"REACTOME:R-MMU-181429",
"REACTOME:R-MMU-181430",
"REACTOME:R-MMU-196108",
"REACTOME:R-MMU-210500",
"REACTOME:R-MMU-212676",
"REACTOME:R-MMU-264... | 18 | [
"2csp",
"6q9m"
] | 2 | [
"PUB00018329",
"PUB00064040",
"PUB00085469",
"PUB00085470",
"PUB00085471",
"PUB00085472",
"PUB00085473",
"PUB00145449",
"PUB00160633",
"PUB00160634",
"PUB00160635"
] | [
"8548820",
"23238252",
"11988172",
"17855024",
"10748113",
"19091768",
"22174254",
"25908590",
"32369542",
"22442152",
"29526433"
] | [
"2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.",
"Combinatorial design of an Anticalin directed against the extra-domain B for the specific targeting of oncofetal fibronectin.",
"RIM binding proteins (RBPs) couple Rab3-interacting molecules (... | [
1996,
2012,
2002,
2007,
2000,
2009,
2011,
2015,
2020,
2012,
2018
] | 11 | [
"IPR003961"
] | [] | 1 | 0 | 1 | [
"Actinomycetes",
"Eukaryota"
] | [
2,
5740
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
136,
10,
23,
8,
18
] | 6 | true | Domain | RIMS-binding protein 1/2/3, Fn3 domain | RIMS-binding protein 1/2/3, Fn3 domain | FN3_RIM-BP1/2/3 | 4 |
IPR057885 | 57,885 | VWDE-like, Ig-like domain | Ig_VWDE | Domain | 1,448 | false | false | This predicted immunoglobulin (Ig) domain is found in VWDE and similar sequences. This domain is often found associated with and . von Willebrand factor D and EGF domain-containing protein (WWDE) is predicted to enable signalling receptor binding activity and to be active in the cell surface and extracellular region. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25776"
] | [
"Ig_VWDE"
] | [
1448
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1448
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
2,
2
] | 4 | true | Domain | VWDE-like, Ig-like domain | VWDE-like, Ig-like domain | Ig_VWDE | 1 |
IPR057886 | 57,886 | Inovirus capsid | Inovirus_capsid | Family | 96 | false | false | This entry represents the Inovirus capsid protein family, which is involved in the formation of helical capsids that encapsulate viral genomic DNA. This family includes Capsid protein G8P (VIII) and Phi-Lf prophage-derived major coat protein (gVIII-1). These proteins self-assemble to create a filamentous structure with... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25631"
] | [
"Inovirus_capsid"
] | [
96
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Brugia timori",
"Pseudomonadota",
"Viruses"
] | [
1,
81,
14
] | 3 | [] | [] | 0 | true | Family | Inovirus capsid | Inovirus capsid | Inovirus_capsid | 2 |
IPR057887 | 57,887 | IQ motif and ubiquitin-like domain-containing protein, helical domain | IQUB_helical | Domain | 1,832 | false | false | This domain is found in IQUB and similar proteins mainly found in vertebrates. This domain is predicted to adopt a predominantly α-structure. IQ motif and ubiquitin-like domain-containing protein (IQUB) is an adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubule... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25805"
] | [
"IQUB"
] | [
1832
] | 1 | [] | [] | [] | 0 | [
"7jtk",
"7jts",
"7ju4",
"8glv",
"8j07",
"9e5c",
"9fqr"
] | 7 | [
"PUB00087484",
"PUB00109497",
"PUB00153393"
] | [
"21289087",
"33318703",
"36355624"
] | [
"Functional characterization of putative cilia genes by high-content analysis.",
"Structures of radial spokes and associated complexes important for ciliary motility.",
"IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3."
] | [
2011,
2021,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1832
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
1,
2
] | 5 | true | Domain | IQ motif and ubiquitin-like domain-containing protein, helical domain | IQ motif and ubiquitin-like domain-containing protein, helical domain | IQUB_helical | 3 |
IPR057888 | 57,888 | Crassvirus muzzle protein, C-terminal domain | crAss_MUZ_C | Domain | 105 | false | false | This entry represents the C-terminal β-sandwich domain from the muzzle protein found at the distal end of some tailed bacteriophages and prophages from bacteroidetes. This large protein forms a hexameric assembly at the tip of the tail barrel and exhibits a novel fold designated as the 'crass fold'. The muzzle protein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25729"
] | [
"crAss_MUZ_C"
] | [
105
] | 1 | [] | [] | [] | 0 | [
"7qok",
"7qol",
"8ckb"
] | 3 | [
"PUB00155591"
] | [
"37138077"
] | [
"Structural atlas of a human gut crassvirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Cylicocyclus nassatus",
"Pseudomonadati",
"Viruses",
"marine sediment metagenome"
] | [
1,
17,
74,
13
] | 4 | [] | [] | 0 | true | Domain | Crassvirus muzzle protein, C-terminal domain | Crassvirus muzzle protein, C-terminal domain | crAss_MUZ_C | 2 |
IPR057889 | 57,889 | Crassvirus muzzle protein, N-terminal region | crAss_MUZ_N | Domain | 124 | false | false | This entry represents the N-terminal region of muzzle protein found at the distal end of the tail in bacteriophages of the Crassviridae family. This large protein forms a hexameric assembly at the tip of the tail barrel and exhibits a novel fold designated as the 'crass fold'. The muzzle protein is composed of five dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25731"
] | [
"crAss_MUZ"
] | [
124
] | 1 | [] | [] | [] | 0 | [
"7qok",
"7qol",
"8ckb"
] | 3 | [
"PUB00155591"
] | [
"37138077"
] | [
"Structural atlas of a human gut crassvirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cylicocyclus nassatus",
"Viruses",
"unclassified sequences"
] | [
14,
1,
89,
20
] | 4 | [] | [] | 0 | true | Domain | Crassvirus muzzle protein, N-terminal region | Crassvirus muzzle protein, N-terminal region | crAss_MUZ_N | 7 |
IPR057890 | 57,890 | KCTD7/14, C-terminal domain | KCTD7/14_C | Domain | 1,877 | false | false | This entry represents the C-terminal domain found in KCTD7 and KCTD14. The domain has a consistent structural motif with three antiparallel β-sheets packing against one α-helix. This domain adopts different interfaces in different KCTD subfamily members, resulting in distinct substrate binding mechanisms. The domain fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25611"
] | [
"KCTD_C"
] | [
1877
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-BTA-983168",
"R-DRE-8951664",
"R-DRE-983168",
"R-GGA-8951664",
"R-GGA-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-DRE-8951664",
"REACTOME:R-DRE-983168",
"REACTOME:R-GGA-8951664",
"REACTOME:R-GGA-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-R... | 12 | [
"8i79"
] | 1 | [
"PUB00142290",
"PUB00142293",
"PUB00160636"
] | [
"27629772",
"21710140",
"37450587"
] | [
"KCTD7-related progressive myoclonus epilepsy.",
"Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons.",
"Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase."
] | [
2016,
2011,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1877
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
4,
4
] | 4 | true | Domain | KCTD7/14, C-terminal domain | KCTD7/14, C-terminal domain | KCTD7/14_C | 1 |
IPR057891 | 57,891 | KCTD7, BTB domain | BTB_KCTD7 | Domain | 1,098 | false | false | This entry represents the BTB domain in KCTD7 proteins. KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurones and is involved in the control of excitability of cortical neurones. K... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd18366"
] | [
"BTB_POZ_KCTD7"
] | [
1098
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-BTA-983168",
"R-DRE-8951664",
"R-DRE-983168",
"R-GGA-8951664",
"R-GGA-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-DRE-8951664",
"REACTOME:R-DRE-983168",
"REACTOME:R-GGA-8951664",
"REACTOME:R-GGA-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-R... | 12 | [
"8i79"
] | 1 | [
"PUB00142285",
"PUB00142286",
"PUB00142287",
"PUB00142288",
"PUB00142289",
"PUB00142290",
"PUB00142291",
"PUB00142292",
"PUB00142293"
] | [
"22748208",
"22693283",
"22638565",
"17455289",
"27742667",
"27629772",
"25060828",
"22606975",
"21710140"
] | [
"A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.",
"Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene.",
"A compound heterozygous missense mutation and a large deletion in the KCTD7 gene presenting as an opsoclonus-myoclonus ataxia... | [
2012,
2012,
2012,
2007,
2016,
2016,
2014,
2012,
2011
] | 9 | [
"IPR003131"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1098
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
2,
1
] | 4 | true | Domain | KCTD7, BTB domain | KCTD7, BTB domain | BTB_KCTD7 | 7 |
IPR057892 | 57,892 | Liprin-alpha, CC2 domain | LIP-1_CC2 | Domain | 9,230 | false | false | This entry describes the dimeric coiled coil (CC2) found in liprin-alpha proteins mainly from animals. The CC2 domain is located after the coiled coil domain 1 (CC1). The long CC2 coiled coils are toward the outside of this CC1 oligomer, making them accessible for recognition by presynaptic binding partners of liprin-a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25526"
] | [
"LIP-1"
] | [
9230
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-181429",
"R-CEL-181430",
"R-CEL-210500",
"R-CEL-212676",
"R-CEL-264642",
"R-CEL-388844",
"R-HSA-181429",
"R-HSA-181430",
"R-HSA-210500",
"R-HSA-212676",
"R-HSA-264642",
"R-HSA-388844",
"R-MMU-181429",
"R-MMU-181430",
"R-MMU-210500",
"R-MMU-212676",
"R-MMU-264642",
"R-MMU-388... | [
"REACTOME:R-CEL-181429",
"REACTOME:R-CEL-181430",
"REACTOME:R-CEL-210500",
"REACTOME:R-CEL-212676",
"REACTOME:R-CEL-264642",
"REACTOME:R-CEL-388844",
"REACTOME:R-HSA-181429",
"REACTOME:R-HSA-181430",
"REACTOME:R-HSA-210500",
"REACTOME:R-HSA-212676",
"REACTOME:R-HSA-264642",
"REACTOME:R-HSA-388... | 24 | [
"8z22"
] | 1 | [
"PUB00065740",
"PUB00070352",
"PUB00072821",
"PUB00072838",
"PUB00072887",
"PUB00160637"
] | [
"21855798",
"22072677",
"9624153",
"21084592",
"17956329",
"33761347"
] | [
"Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.",
"The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.",
"Liprins, a family of LAR transmembrane protein-tyrosine pho... | [
2011,
2011,
1998,
2010,
2007,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Metazoa"
] | [
5,
9225
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
101,
4,
27,
14,
25
] | 6 | true | Domain | Liprin-alpha, CC2 domain | Liprin-alpha, CC2 domain | LIP-1_CC2 | 4 |
IPR057893 | 57,893 | Leucine rich repeat variant domain | LRV_2 | Domain | 1,519 | false | false | This entry represents a likely small cytoplasmic domain found in a small set of bacterial integral membrane proteins. This domain is composed of a couple of leucine-rich repeat variants. The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25591"
] | [
"LRV_2"
] | [
1519
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes",
"unclassified Caudoviricetes"
] | [
2,
1510,
4,
3
] | 4 | [] | [] | 0 | true | Domain | Leucine rich repeat variant domain | Leucine rich repeat variant domain | LRV_2 | 9 |
IPR057894 | 57,894 | Major capsid protein 1 | MCP1_SIFV | Family | 8 | false | false | This entry represents the major capsid protein 1 (MCP1) found in filamentous viruses that infect hyperthermophilic archaea living in extreme environments (temperatures of 80-90 degrees C with pH values of 2-3). The MCP1 proteins form either homodimers or heterodimers with MCP2 and wrap around the viral DNA, maintaining... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25654"
] | [
"MCP1_SIFV"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"6wq2",
"7txj"
] | 2 | [
"PUB00022136",
"PUB00151862",
"PUB00160638",
"PUB00160651"
] | [
"12411581",
"28639939",
"32759221",
"32368353"
] | [
"The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus.",
"Model for a novel membrane envelope in a filamentous hyperthermophilic virus.",
"Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments.",
"Struc... | [
2002,
2017,
2020,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Acidianus hospitalis",
"Betalipothrixvirus"
] | [
1,
7
] | 2 | [] | [] | 0 | true | Family | Major capsid protein 1 | Major capsid protein 1 | MCP1_SIFV | 6 |
IPR057895 | 57,895 | Mom | Mom | Family | 899 | false | false | The Mom protein family comprises iron-binding proteins that catalyse the methylcarbamoylation of adenine using acetyl-Coa. This modification, known as momylation, converts adenine into N6-methylcarbamoyl adenine, rendering viral DNA resistant to various host type I and type II restriction enzymes. Approximately 15% of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25680"
] | [
"Mom"
] | [
899
] | 1 | [] | [] | [] | 0 | [
"8bv8"
] | 1 | [
"PUB00160923",
"PUB00160924"
] | [
"1258376",
"32369169"
] | [
"The DNA modification function of temperate phage Mu-1.",
"Emergence of a novel immune-evasion strategy from an ancestral protein fold in bacteriophage Mu."
] | [
1976,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
6,
690,
3,
130,
70
] | 5 | [] | [] | 0 | true | Family | Mom | Mom | Mom | 9 |
IPR057896 | 57,896 | Mitochondrial transcription rescue factor 1, C-terminal domain | MTRES1_C | Domain | 1,175 | false | false | This domain is found at the C-terminal end of MTRES1 and related proteins. This domain is predicted to fold as a β-sheet with two α-helices on one side. Mitochondrial transcription rescue factor 1 (MTRES1) is a mitochondrial RNA-binding protein involved in the regulation of mitochondrial transcription. It functions as ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25818"
] | [
"MTRES1_C"
] | [
1175
] | 1 | [
"REACTOME"
] | [
"R-HSA-9937383"
] | [
"REACTOME:R-HSA-9937383"
] | 1 | [
"7a5h"
] | 1 | [
"PUB00093595",
"PUB00160854",
"PUB00160855"
] | [
"31226201",
"31396629",
"33243891"
] | [
"Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria.",
"C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis.",
"Elongational stalling activates mitoribosome-associated quality control."
] | [
2019,
2019,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Metazoa"
] | [
22,
1153
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
5
] | 5 | true | Domain | Mitochondrial transcription rescue factor 1, C-terminal domain | Mitochondrial transcription rescue factor 1, C-terminal domain | MTRES1_C | 1 |
IPR057897 | 57,897 | Gp73 | Gp73 | Family | 2 | false | false | This entry represents a family of small proteins found in mycobacteriophages, typified by the gene 73 protein (Gp73) from Mycobacteriophage L5. The function of this protein family is currently unknown. The protein is relatively small (85 amino acids) and appears to be phage-specific. Mycobacteriophage L5 is a temperate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25718"
] | [
"Mycobacteriophage_73"
] | [
2
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Fromanvirus"
] | [
2
] | 1 | [] | [] | 0 | true | Family | Gp73 | Gp73 | Gp73 | 8 |
IPR057898 | 57,898 | Gp3 | Gp3 | Family | 11 | false | false | This entry represents a family of small proteins found in mycobacteriophages. Members of this family include the Gene 3 protein (Gp3) from mycobacteriophages L5 and D29, which belong to the Fromanvirus genus. The function of these proteins remains unknown. The proteins are approximately 83 amino acids in length and sho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25687"
] | [
"Mycobacteriophage_Gene3"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Paraburkholderia bengalensis"
] | [
10,
1
] | 2 | [] | [] | 0 | true | Family | Gp3 | Gp3 | Gp3 | 8 |
IPR057899 | 57,899 | Gp53 | Gp53 | Family | 328 | false | false | This entry represents the mycobacteriophage Gene 53 protein (Gp53) found in phages such as L5 and D29 that infect Mycobacterium species. The specific function of this protein has not been experimentally determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25684"
] | [
"Mycobacteriophage_Gp53"
] | [
328
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
28,
300
] | 2 | [] | [] | 0 | true | Family | Gp53 | Gp53 | Gp53 | 3 |
IPR057900 | 57,900 | Gp67, mycobacteriophage L5 | Gp67_L5 | Family | 16 | false | false | This entry represents a small protein found in mycobacteriophage L5 and related phages Gp67. The protein is 43 amino acids in length. The specific function of this protein remains to be determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25715"
] | [
"Mycobacteriophage_Gp67"
] | [
16
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Gp67, mycobacteriophage L5 | Gp67, mycobacteriophage L5 | Gp67_L5 | 9 |
IPR057901 | 57,901 | Gp42 | Gp42 | Family | 166 | false | false | This entry represents the Gene 42 protein (Gp42) found in mycobacteriophages such as D29 and L5. These are small proteins of approximately 70 amino acids in length. The specific function of this protein family is currently unknown. The predicted structure contains a three-stranded β-sheet with an α-helix between strand... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25674"
] | [
"Mycophage_Gp42"
] | [
166
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
3,
163
] | 2 | [] | [] | 0 | true | Family | Gp42 | Gp42 | Gp42 | 7 |
IPR057902 | 57,902 | Transcriptional antitermination N peptide | N_peptide | Family | 1,023 | false | false | This entry represents the bacteriophage N protein (or Probable regulatory protein N), which plays an essential role in transcriptional antitermination. Upon interaction with the N-utilisation (nut) site on the nascent phage transcript, and together with host factors, the N protein converts the RNA polymerase to a termi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25694"
] | [
"N_peptide"
] | [
1023
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00036221"
] | [
"9501914"
] | [
"Solution structure of P22 transcriptional antitermination N peptide-boxB RNA complex."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Lasius niger",
"Viruses"
] | [
937,
1,
85
] | 3 | [] | [] | 0 | true | Family | Transcriptional antitermination N peptide | Transcriptional antitermination N peptide | N_peptide | 4 |
IPR057903 | 57,903 | Bacteriophage N4, Gp8 | Phage_N4_Gp8 | Family | 33 | false | false | This entry represents Gene product 8 (Gp8), a phage-encoded inhibitor of bacterial DNA replication. The protein is encoded by coliphage N4 and targets the host DNA sliding clamp by interacting with the delta subunit of the E. coli DNA polymerase III clamp loader. The protein inhibits replication elongation and is bacte... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25713"
] | [
"N4_GP8"
] | [
33
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160641"
] | [
"21205014"
] | [
"A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Pantoea brenneri",
"Viruses"
] | [
1,
32
] | 2 | [] | [] | 0 | true | Family | Bacteriophage N4, Gp8 | Bacteriophage N4, Gp8 | Phage_N4_Gp8 | 6 |
IPR057904 | 57,904 | Nal1, C-terminal domain | Nal1_C | Domain | 1,594 | false | false | This entry represents the C-terminal in Nal1 found in rice and related plant proteins. The C-terminal of Nal1 has been determined to have serine protease activity. It consists of two perpendicular six-stranded β-barrel subdomains, and the putative catalytic triad is composed of H233, D291 and S385 [ ]. This entry also ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25819"
] | [
"Nal1_C"
] | [
1594
] | 1 | [] | [] | [] | 0 | [
"7y77",
"8has",
"8hat",
"8hau",
"8pme",
"8pmg",
"8pmi",
"8pml",
"8pmm",
"8pn1",
"8pn2"
] | 11 | [
"PUB00160642",
"PUB00160643",
"PUB00160644"
] | [
"23985993",
"18562767",
"37349549"
] | [
"A natural variant of NAL1, selected in high-yield rice breeding programs, pleiotropically increases photosynthesis rate.",
"Mutation of the rice Narrow leaf1 gene, which encodes a novel protein, affects vein patterning and polar auxin transport.",
"Serine protease NAL1 exerts pleiotropic functions through degr... | [
2013,
2008,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Oxyplasma meridianum",
"ecological metagenomes"
] | [
134,
1456,
1,
3
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
5,
45
] | 3 | true | Domain | Nal1, C-terminal domain | Nal1, C-terminal domain | Nal1_C | 2 |
IPR057905 | 57,905 | Nal1, N-terminal domain | Nal1_N | Domain | 1,515 | false | false | This entry represents the N-terminal domain in Nal1 found in rice and other plants. This domain contains an ATP-binding pocket that mediates the formation of a hexameric structure consisting of two stacked trimeric rings. ATP is embedded in a positively charged pocket stabilised by a network of residues, including R120... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25608"
] | [
"NAL1_N"
] | [
1515
] | 1 | [] | [] | [] | 0 | [
"7y77",
"8has",
"8hat",
"8hau",
"8pme",
"8pmg",
"8pmi",
"8pml",
"8pmm",
"8pn1",
"8pn2"
] | 11 | [
"PUB00160642",
"PUB00160643",
"PUB00160644"
] | [
"23985993",
"18562767",
"37349549"
] | [
"A natural variant of NAL1, selected in high-yield rice breeding programs, pleiotropically increases photosynthesis rate.",
"Mutation of the rice Narrow leaf1 gene, which encodes a novel protein, affects vein patterning and polar auxin transport.",
"Serine protease NAL1 exerts pleiotropic functions through degr... | [
2013,
2008,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Streptophyta",
"ecological metagenomes"
] | [
174,
4,
1332,
5
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
5,
20
] | 3 | true | Domain | Nal1, N-terminal domain | Nal1, N-terminal domain | Nal1_N | 7 |
IPR057906 | 57,906 | Narrow leaf 1 | Nal1 | Family | 1,537 | false | false | Narrow leaf 1 (Nal1) is a serine protease with pleiotropic roles in plant development, affecting several agronomic traits including leaf width, plant height, root architecture, and grain yield [ ]. Nal1 regulates lateral leaf growth by modulating basipetal polar auxin transport and vascular patterning, which are essent... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31521"
] | [
""
] | [
1537
] | 1 | [] | [] | [] | 0 | [
"7y77",
"8has",
"8hat",
"8hau",
"8pme",
"8pmg",
"8pmi",
"8pml",
"8pmm",
"8pn1",
"8pn2"
] | 11 | [
"PUB00160642",
"PUB00160643"
] | [
"23985993",
"18562767"
] | [
"A natural variant of NAL1, selected in high-yield rice breeding programs, pleiotropically increases photosynthesis rate.",
"Mutation of the rice Narrow leaf1 gene, which encodes a novel protein, affects vein patterning and polar auxin transport."
] | [
2013,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Streptophyta"
] | [
12,
1525
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
6,
45
] | 3 | true | Family | Narrow leaf 1 | Narrow leaf 1 | Nal1 | 7 |
IPR057907 | 57,907 | Minor capsid protein P6 | NCLDV_P6 | Family | 8 | false | false | This entry represents the minor capsid protein P6 found in nucleocytoplasmic large DNA viruses (NCLDVs). In Paramecium bursaria chlorella virus 1 (PBCV-1), P6 plays a role in stabilising the pentasymmetron structures of the viral capsid. The protein has a distinctive structural organisation with an N-terminal arm (resi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25663"
] | [
"NCLDV_minor_capsid_P6"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"6ncl",
"8h2i"
] | 2 | [
"PUB00154526"
] | [
"30674888"
] | [
"Near-atomic structure of a giant virus."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Chlorovirus"
] | [
8
] | 1 | [] | [] | 0 | true | Family | Minor capsid protein P6 | Minor capsid protein P6 | NCLDV_P6 | 2 |
IPR057909 | 57,909 | Neuregulin 2, N-terminal domain | NRG2_N | Domain | 1,475 | false | false | This domain is found at the N-terminal in NRG2. This domain is predicted to fold into a β-barrel with an OB-fold topology. It is closely related to . This domain is not present in other neuregulin proteins such as NRG1 and NRG3. Neuregulin 2 (NRG2) belongs to the neuregulin family and plays important roles in cell comm... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25518"
] | [
"NRG2_N"
] | [
1475
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1227986",
"R-HSA-1236394",
"R-HSA-1250196",
"R-HSA-1250342",
"R-HSA-1250347",
"R-HSA-1251985",
"R-HSA-1257604",
"R-HSA-1306955",
"R-HSA-1358803",
"R-HSA-1963640",
"R-HSA-1963642",
"R-HSA-2219530",
"R-HSA-5673001",
"R-HSA-6785631",
"R-HSA-6811558",
"R-HSA-8847993",
"R-HSA-88637... | [
"REACTOME:R-HSA-1227986",
"REACTOME:R-HSA-1236394",
"REACTOME:R-HSA-1250196",
"REACTOME:R-HSA-1250342",
"REACTOME:R-HSA-1250347",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-1306955",
"REACTOME:R-HSA-1358803",
"REACTOME:R-HSA-1963640",
"REACTOME:R-HSA-1963642",
"REACTOM... | 49 | [] | 0 | [
"PUB00003030",
"PUB00004316",
"PUB00004928",
"PUB00160645"
] | [
"9804837",
"9208852",
"9892702",
"9348101"
] | [
"Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment.",
"Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.",
"Failure of spinal cord oligodendro... | [
1998,
1997,
1999,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1475
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
5,
6,
16
] | 4 | true | Domain | Neuregulin 2, N-terminal domain | Neuregulin 2, N-terminal domain | NRG2_N | 2 |
IPR057910 | 57,910 | Nanos, NED domain | NED_Nanos | Domain | 74 | false | false | This entry represents the effector domain (NED) of Nanos from Drosophila melanogaster and related proteins. This domain is necessary to repress mRNA targets. The NED domain recruits the CCR4-NOT complex through multiple and redundant binding sites, including a central region that interacts with the NOT module, which co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25798"
] | [
"NED_Nanos"
] | [
74
] | 1 | [] | [] | [] | 0 | [
"5fu7"
] | 1 | [
"PUB00151568",
"PUB00157032"
] | [
"26968986",
"1908748"
] | [
"Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos.",
"Nanos is the localized posterior determinant in Drosophila."
] | [
2016,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Cyclorrhapha"
] | [
74
] | 1 | [
"Drosophila melanogaster"
] | [
11
] | 1 | true | Domain | Nanos, NED domain | Nanos, NED domain | NED_Nanos | 7 |
IPR057911 | 57,911 | Neuregulin 2, Ig-like domain | NRG2_Ig-like | Domain | 926 | false | false | This entry represents the Ig-like domain in NRG2 and related proteins, mainly found in mammals. Neuregulin 2 (NRG2) belongs to the neuregulin family and plays important roles in cell communication. It serves as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors [ ]. NRG2 recruits ERBB1 and ERBB2 coreceptors,... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd05750"
] | [
"Ig_Pro_neuregulin"
] | [
926
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1227986",
"R-HSA-1236394",
"R-HSA-1250196",
"R-HSA-1250342",
"R-HSA-1250347",
"R-HSA-1251985",
"R-HSA-1257604",
"R-HSA-1306955",
"R-HSA-1358803",
"R-HSA-1963640",
"R-HSA-1963642",
"R-HSA-2219530",
"R-HSA-5673001",
"R-HSA-6785631",
"R-HSA-6811558",
"R-HSA-8847993",
"R-HSA-88637... | [
"REACTOME:R-HSA-1227986",
"REACTOME:R-HSA-1236394",
"REACTOME:R-HSA-1250196",
"REACTOME:R-HSA-1250342",
"REACTOME:R-HSA-1250347",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-1306955",
"REACTOME:R-HSA-1358803",
"REACTOME:R-HSA-1963640",
"REACTOME:R-HSA-1963642",
"REACTOM... | 49 | [] | 0 | [
"PUB00003030",
"PUB00003330",
"PUB00004316",
"PUB00004928",
"PUB00018311",
"PUB00083154",
"PUB00119181",
"PUB00119182",
"PUB00119183",
"PUB00160645"
] | [
"9804837",
"7932691",
"9208852",
"9892702",
"9541533",
"10358755",
"7816098",
"15207852",
"9685585",
"9348101"
] | [
"Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment.",
"The immunoglobulin fold. Structural classification, sequence patterns and common core.",
"Neuregulins and their receptors: a versatil... | [
1998,
1994,
1997,
1999,
1998,
1999,
1995,
2004,
1998,
1997
] | 10 | [
"IPR013098"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
926
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
4,
3,
9
] | 4 | true | Domain | Neuregulin 2, Ig-like domain | Neuregulin 2, Ig-like domain | NRG2_Ig-like | 2 |
IPR057912 | 57,912 | Mitochondrial protein cyt-4, OB-fold C-terminal domain | OB_CYT4_C | Domain | 699 | false | false | This OB-fold domain is found at the C-terminal in CYT4 from Neurospora crassa and related proteins. This domain is usually found next to . CYT4 is a nuclear-encoded protein that plays a crucial role in RNA processing and splicing within mitochondria [ , ]. CYT4 is required for mitochondrial RNA 5'- and 3'-end processin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25522"
] | [
"OB_cyt-4"
] | [
699
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159023",
"PUB00160646"
] | [
"2478417",
"1311848"
] | [
"Mutations in nuclear gene cyt-4 of Neurospora crassa result in pleiotropic defects in processing and splicing of mitochondrial RNAs.",
"A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions."
] | [
1989,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
699
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Mitochondrial protein cyt-4, OB-fold C-terminal domain | Mitochondrial protein cyt-4, OB-fold C-terminal domain | OB_CYT4_C | 8 |
IPR057913 | 57,913 | Capsid protein ORF3b | ORF3b | Family | 4 | false | false | This entry represents the coat (capsid) protein ORF3b family found in Oleavirus genus members of the Bromoviridae family, including Olive latent virus 2. The capsid protein self-assembles to form a quasi-spherical capsid of approximately 26 nm, or in a bacilliform shape. The protein is part of the virion and functions ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25664"
] | [
"Oleavirus_coat"
] | [
4
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Olive latent virus 2"
] | [
4
] | 1 | [] | [] | 0 | true | Family | Capsid protein ORF3b | Capsid protein ORF3b | ORF3b | 2 |
IPR057915 | 57,915 | Viral coat protein P2, C-terminal domain | P2_C | Domain | 317 | false | false | This entry represents the C-terminal jelly roll domain of P2. P2 (30.2kDa) is the major outer-coat protein of the marine lipid-containing bacteriophage PM2. Each subunit of P2 is composed of two β-barrel jelly rolls, disposed normally to the surface of the capsid, which lend pseudo-6-fold symmetry to the molecules, fac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25513"
] | [
"P2_C"
] | [
317
] | 1 | [] | [] | [] | 0 | [
"2vvf",
"2w0c"
] | 2 | [
"PUB00049918"
] | [
"18775333"
] | [
"Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"Vinavirales",
"unclassified sequences"
] | [
2,
281,
27,
7
] | 4 | [] | [] | 0 | true | Domain | Viral coat protein P2, C-terminal domain | Viral coat protein P2, C-terminal domain | P2_C | 8 |
IPR057916 | 57,916 | DNA transfer protein Gp7 | P22_gp7 | Family | 648 | false | false | This entry represents the bacteriophage P22 DNA ejection protein Gp7. This protein is one of three ejection proteins (along with Gp16 and Gp20) that are required to facilitate the transport of bacteriophage P22 double-stranded DNA safely through the membranes of Salmonella [ ]. These ejection proteins are lost from the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25688"
] | [
"P22_gp7"
] | [
648
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160647",
"PUB00160648",
"PUB00160649"
] | [
"29590587",
"26245366",
"30886360"
] | [
"Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release.",
"Bacteriophage P22 ejects all of its internal proteins before its genome.",
"Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography."
] | [
2018,
2015,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota"
] | [
604,
42,
2
] | 3 | [] | [] | 0 | true | Family | DNA transfer protein Gp7 | DNA transfer protein Gp7 | P22_gp7 | 1 |
IPR057917 | 57,917 | Minor capsid protein P4 | PBCV_P4 | Family | 8 | false | false | This entry represents a small family of putative metallopeptidases found in the phycodnaviridae group. In Paramecium bursaria chlorella virus (PBCV), a member of this family has been identified as minor capsid protein P4. These proteins contain a HEXXH motif characteristic of metallopeptidases. The P4 protein plays a s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25661"
] | [
"PBCV_P4"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"6ncl",
"8h2i"
] | 2 | [
"PUB00154526"
] | [
"30674888"
] | [
"Near-atomic structure of a giant virus."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Chlorovirus"
] | [
8
] | 1 | [] | [] | 0 | true | Family | Minor capsid protein P4 | Minor capsid protein P4 | PBCV_P4 | 4 |
IPR057918 | 57,918 | Bacteriophage PhiKZ vertex-binding protein gp86 | PhiKZ_Gp86 | Family | 14 | false | false | This entry represents the vertex-binding protein gp86 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa [ ]. This protein is a product of proteolytic cleavage by the head maturation protease Gp175, with the N terminus of the modelled part located near verified proteolytic sites. Gp86 has an elongated s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25617"
] | [
"PhiKZ_gp86"
] | [
14
] | 1 | [] | [] | [] | 0 | [
"8y6v"
] | 1 | [
"PUB00160659",
"PUB00160856"
] | [
"36433970",
"39095371"
] | [
"High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.",
"Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages."
] | [
2022,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
14
] | 1 | [] | [] | 0 | true | Family | Bacteriophage PhiKZ vertex-binding protein gp86 | Bacteriophage PhiKZ vertex-binding protein gp86 | PhiKZ_Gp86 | 3 |
IPR057919 | 57,919 | Bacteriophage PhiKZ vertex-binding protein gp91 | PhiKZ_Gp91 | Family | 51 | false | false | This entry represents the vertex-binding protein Gp91 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa [ ]. This α-helical protein is a component of the vertex-binding complex attached to the inner surface of the viral capsid. Gp91 extends towards the capsid vertex and, unlike other members of the ver... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25618"
] | [
"PhiKZ_gp91"
] | [
51
] | 1 | [] | [] | [] | 0 | [
"8y6v"
] | 1 | [
"PUB00160659",
"PUB00160856"
] | [
"36433970",
"39095371"
] | [
"High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.",
"Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages."
] | [
2022,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Habropoda laboriosa",
"Salmonella enterica I",
"Viruses"
] | [
1,
3,
47
] | 3 | [] | [] | 0 | true | Family | Bacteriophage PhiKZ vertex-binding protein gp91 | Bacteriophage PhiKZ vertex-binding protein gp91 | PhiKZ_Gp91 | 8 |
IPR057920 | 57,920 | Bacteriophage PhiKZ major capsid protein gp120 | PhiKZ_MCP | Family | 80 | false | false | This entry represents the major capsid protein (MCP) gp120 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa [ ]. It is the main structural component of the viral capsid with a triangulation number T=27 (h=3, k=3). The protein undergoes proteolytic cleavage between residues Glu163 and Asn164, with only... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25620"
] | [
"PhiKZ_MCP"
] | [
80
] | 1 | [] | [] | [] | 0 | [
"8bfl",
"8bfp",
"8y6v"
] | 3 | [
"PUB00160659",
"PUB00160856"
] | [
"36433970",
"39095371"
] | [
"High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.",
"Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages."
] | [
2022,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Viruses"
] | [
6,
74
] | 2 | [] | [] | 0 | true | Family | Bacteriophage PhiKZ major capsid protein gp120 | Bacteriophage PhiKZ major capsid protein gp120 | PhiKZ_MCP | 3 |
IPR057922 | 57,922 | Minor capsid protein P12/P13, Phycodnaviridae | P12/P13 | Family | 16 | false | false | This entry represents the minor capsid proteins P12 and P13 of the Paramecium bursaria chlorella virus 1 (PBCV-1). P13 is one of the thirteen minor capsid proteins found in the viral capsid. The structure of P13 consists of a helical domain with a region at the N terminus (residues 4-23) predicted to be a transmembrane... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25630"
] | [
"Phycodna_minor_capsid"
] | [
16
] | 1 | [] | [] | [] | 0 | [
"6ncl",
"8h2i"
] | 2 | [
"PUB00154526"
] | [
"30674888"
] | [
"Near-atomic structure of a giant virus."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Chlorovirus"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Minor capsid protein P12/P13, Phycodnaviridae | Minor capsid protein P12/P13, Phycodnaviridae | P12/P13 | 6 |
IPR057923 | 57,923 | Putative capsid protein ORF9, Plectrovirus | Plectro_ORF9 | Family | 77 | false | false | This protein family includes ORF9 capsid protein from Plectrovirus, and similar prophages from Spiroplasma. These proteins, which are involved in the formation of viral capsids, may self-assemble to form a helical capsid structure, which encapsulates the viral genomic DNA. The process of virion assembly and budding occ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25626"
] | [
"Plectro_ORF9"
] | [
77
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spiroplasma",
"Vespertiliovirus"
] | [
74,
3
] | 2 | [] | [] | 0 | true | Family | Putative capsid protein ORF9, Plectrovirus | Putative capsid protein ORF9, Plectrovirus | Plectro_ORF9 | 2 |
IPR057924 | 57,924 | Minor capsid protein VP2, Polyomaviruses | Polyoma_VP2 | Family | 278 | false | false | The polyomaviruses capsid protein VP2 function as a structural component within the viral capsid, residing in the core surrounded by VP1 pentamers. It plays a crucial role in host cell receptor binding in conjunction with VP1. After the virus undergoes endocytosis and reaches the endoplasmic reticulum, VP2 and VP3 olig... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25627"
] | [
"Polyoma_VP2"
] | [
278
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Polyomaviridae"
] | [
278
] | 1 | [] | [] | 0 | true | Family | Minor capsid protein VP2, Polyomaviruses | Minor capsid protein VP2, Polyomaviruses | Polyoma_VP2 | 6 |
IPR057925 | 57,925 | Double-stranded DNA deaminase toxin A, prePAAR motif | prePAAR_DddA | Domain | 1,066 | false | false | This motif, known as prePAAR motif, is found at the N-terminal of the class I prePAAR effector Rhs1 from Salmonella Typhimurium, Double-stranded DNA deaminase toxin A from Burkholderia cenocepacia (DddA) and related proteins mainly from proteobacteria. prePAAR facilitates PAAR domain interaction with the VgrG spike [ ]... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25799"
] | [
"prePAAR_I"
] | [
1066
] | 1 | [] | [] | [] | 0 | [
"6xrr"
] | 1 | [
"PUB00097193",
"PUB00100580"
] | [
"32641830",
"33320089"
] | [
"A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.",
"Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones."
] | [
2020,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
1066
] | 1 | [] | [] | 0 | true | Domain | Double-stranded DNA deaminase toxin A, prePAAR motif | Double-stranded DNA deaminase toxin A, prePAAR motif | prePAAR_DddA | 2 |
IPR057926 | 57,926 | QRICH1-like domain | QRICH1_dom | Domain | 6,551 | false | false | This domain is found in human Transcriptional regulator QRICH1 and similar proteins, mainly found in animals, including ZMYM2/3/4. This domain is predicted to adopt a mainly α-structure. QRICH1 acts as a mediator of the integrated stress response through transcriptional control of protein homeostasis under conditions o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25561"
] | [
"QRICH1"
] | [
6551
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1839117",
"R-HSA-5655302",
"R-HSA-9703465",
"R-HSA-9764725",
"R-MMU-9764725"
] | [
"REACTOME:R-HSA-1839117",
"REACTOME:R-HSA-5655302",
"REACTOME:R-HSA-9703465",
"REACTOME:R-HSA-9764725",
"REACTOME:R-MMU-9764725"
] | 5 | [
"9hjt",
"9hju"
] | 2 | [
"PUB00160857",
"PUB00160920",
"PUB00160921",
"PUB00160922"
] | [
"33384352",
"28242625",
"32439918",
"35253893"
] | [
"QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.",
"ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.",
"Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.",
"ZMYM2 restricts 53BP1 at DNA double-s... | [
2021,
2017,
2020,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6551
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
32,
9,
16,
13,
21
] | 5 | true | Domain | QRICH1-like domain | QRICH1-like domain | QRICH1_dom | 2 |
IPR057927 | 57,927 | Checkpoint protein RAD24-like, helical bundle | RAD24-like_helical | Domain | 1,948 | false | false | This domain is found in Checkpoint protein RAD24 from Saccharomyces cerevisiae, its orthologue in Schizosaccharomyces pombe Rad17 [ ], and similar sequences mainly found in fungi. RAD24 participates in checkpoint pathways arrest of the cell cycle, a mechanism that allows the DNA repair pathways to act to restore the in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25812"
] | [
"RAD24_helical"
] | [
1948
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-176187",
"R-SPO-176187"
] | [
"REACTOME:R-SCE-176187",
"REACTOME:R-SPO-176187"
] | 2 | [
"7sgz",
"7sh2",
"7st9",
"7stb",
"7ste",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8"
] | 12 | [
"PUB00017486",
"PUB00059229",
"PUB00160664",
"PUB00160665",
"PUB00160666",
"PUB00160858"
] | [
"8846774",
"12604797",
"35314830",
"35939393",
"37205533",
"11486023"
] | [
"Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.",
"Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.",
"DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp... | [
1995,
2003,
2022,
2022,
2023,
2001
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1948
] | 1 | [
"Danio rerio",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1,
1
] | 4 | true | Domain | Checkpoint protein RAD24-like, helical bundle | Checkpoint protein RAD24-like, helical bundle | RAD24-like_helical | 6 |
IPR057929 | 57,929 | RamC, N-terminal domain | RamC_N | Domain | 3,111 | false | false | This domain is found at the N-terminal end of RamC. Probable SapB synthase from Streptomyces coelicolor (RamC) is required for aerial hyphae formation [ , , ]. It is probably involved in processing the precursor of SapB to its mature form. It shows an α-β configuration. This protein is part of the LanC-like protein sup... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25816"
] | [
"RamC_N"
] | [
3111
] | 1 | [] | [] | [] | 0 | [
"8car",
"8cav",
"8sam",
"8sao",
"8sap",
"8w7a",
"8w7j",
"8w7l",
"8wgo",
"9ugq"
] | 10 | [
"PUB00160667",
"PUB00160668",
"PUB00160669",
"PUB00160859",
"PUB00160860",
"PUB00160861"
] | [
"37014271",
"37901177",
"39154050",
"12100547",
"12169618",
"12453210"
] | [
"Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.",
"Structure and Function of a Class III Metal-Independent Lanthipeptide Synthetase.",
"Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers.",
"T... | [
2023,
2023,
2024,
2002,
2002,
2002
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"mine drainage metagenome"
] | [
3108,
1,
2
] | 3 | [] | [] | 0 | true | Domain | RamC, N-terminal domain | RamC, N-terminal domain | RamC_N | 9 |
IPR057930 | 57,930 | Antitoxin, putative | Antitoxin_put | Family | 207 | false | false | This entry represents a putative family of bacterial antitoxin proteins that interact with ParE-like toxin proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25734"
] | [
"RelB_like_antitoxin"
] | [
207
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
206,
1
] | 2 | [] | [] | 0 | true | Family | Antitoxin, putative | Antitoxin, putative | Antitoxin_put | 8 |
IPR057931 | 57,931 | ERCC6L2-like, ribbon-helix-helix domain | RHH_ERCC6L2 | Domain | 1,917 | false | false | This is the ribbon-helix-helix (RHH) domain of human ERCC6L2. ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) is a member of the DEAD-like helicase superfamily, a diverse group of proteins involved in ATP-dependent RNA or DNA unwinding. ERCC6L2 may contribute to both DNA repair and mitochondrial function,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25806"
] | [
"RHH_ERCC6L2"
] | [
1917
] | 1 | [
"EC",
"METACYC"
] | [
"3.6.4.-",
"PWY-7250"
] | [
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 2 | [] | 0 | [
"PUB00160862",
"PUB00160863"
] | [
"2450777",
"37014751"
] | [
"Cytological evidence on the ability of the nucleolus organizing regions to assemble pre-existing nucleolar material.",
"ERCC6L2 mitigates replication stress and promotes centromere stability."
] | [
1988,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1917
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
4,
3,
1,
1,
4
] | 5 | true | Domain | ERCC6L2-like, ribbon-helix-helix domain | ERCC6L2-like, ribbon-helix-helix domain | RHH_ERCC6L2 | 9 |
IPR057932 | 57,932 | Nesprin-1/3, spectrin repeats region | Spectrin_SYNE1_3 | Domain | 2,559 | false | false | This entry represents a region of spectrin repeats found in human Nesprin-1/3 (SYNE1/3) and similar proteins from vertebrates. SYNE1 is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organisation [ ]. This protein has been... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25803"
] | [
"Spectrin_SYNE1_2"
] | [
2559
] | 1 | [
"REACTOME"
] | [
"R-HSA-1221632"
] | [
"REACTOME:R-HSA-1221632"
] | 1 | [] | 0 | [
"PUB00102474",
"PUB00102478",
"PUB00102479",
"PUB00160864"
] | [
"17159980",
"18396275",
"17761684",
"21937718"
] | [
"Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia.",
"Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.",
"Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are criti... | [
2007,
2008,
2007,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2559
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
7,
3,
14
] | 4 | true | Domain | Nesprin-1/3, spectrin repeats region | Nesprin-1/3, spectrin repeats region | Spectrin_SYNE1_3 | 4 |
IPR057933 | 57,933 | Nesprin-3 domain | SYNE3_dom | Domain | 1,180 | false | false | This region is found in human Nesprin-3 (SYNE3), a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. SYNE3 plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25804"
] | [
"SYNE3"
] | [
1180
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00072124",
"PUB00160864"
] | [
"16330710",
"21937718"
] | [
"Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin.",
"Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization."
] | [
2005,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1180
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
5
] | 4 | true | Domain | Nesprin-3 domain | Nesprin-3 domain | SYNE3_dom | 9 |
IPR057934 | 57,934 | Spt5, KOW domain repeat 7 | KOW_Spt5_7 | Domain | 2,888 | false | false | This entry represents the seventh KOW domain of Spt5 from animals, which is located at the very C-terminal of the sequences [ ]. Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminal. Spt5 is involved in transcription elongation and termination. The KOW domain is known as an RNA-binding m... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF23287",
"cd06086"
] | [
"KOW7_SPT5",
"KOW_Spt5_6"
] | [
2883,
2513
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-112382",
"R-CEL-113418",
"R-CEL-674695",
"R-CEL-6796648",
"R-CEL-72086",
"R-CEL-75955",
"R-CEL-77075",
"R-DME-112382",
"R-DME-113418",
"R-DME-674695",
"R-DME-6796648",
"R-DME-6807505",
"R-DME-72086",
"R-DME-75955",
"R-DME-77075",
"R-DRE-674695",
"R-DRE-6796648",
"R-DRE-72086... | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-113418",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6796648",
"REACTOME:R-CEL-72086",
"REACTOME:R-CEL-75955",
"REACTOME:R-CEL-77075",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-113418",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6796648",
"REACTOME:R-DME-6807... | 45 | [
"5ohq",
"5oik",
"6er0",
"6gmh",
"6gml",
"6ted",
"7okx",
"7oky",
"7ol0",
"7pks",
"7unc",
"7und",
"7ycx",
"8a3y",
"8p4c",
"8p4d",
"8p4e",
"8p4f",
"8rbx",
"8uha",
"8uhd",
"8uhg",
"8ui0",
"8uis",
"8w8e",
"8w8f",
"8xrm",
"9egx",
"9egy",
"9egz",
"9eh0",
"9eh2"... | 45 | [
"PUB00005458",
"PUB00053827",
"PUB00061569",
"PUB00092162",
"PUB00092163",
"PUB00092164",
"PUB00092166",
"PUB00101034",
"PUB00155699",
"PUB00155701",
"PUB00155703"
] | [
"8987397",
"19000817",
"20197319",
"22982195",
"22306403",
"9199507",
"21467036",
"33846633",
"28892040",
"26217010",
"30733384"
] | [
"KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins.",
"Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.",
"Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.",
"The Spt4-S... | [
1996,
2008,
2010,
2013,
2012,
1997,
2011,
2021,
2017,
2015,
2019
] | 11 | [] | [] | 0 | 0 | null | [
"Candidatus Doudnabacteria bacterium CG10_big_fil_rev_8_21_14_0_10_41_10",
"Eukaryota",
"bird metagenome"
] | [
1,
2886,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
5,
1,
4,
1,
6,
6,
20
] | 9 | true | Domain | Spt5, KOW domain repeat 7 | Spt5, KOW domain repeat 7 | KOW_Spt5_7 | 6 |
IPR057935 | 57,935 | Spt5, KOW domain repeat 6, plant | KOW_Spt5_6_plant | Domain | 884 | false | false | This entry represents the KOW6 domain found in Spt5 in plants that is located between domains KOW5 and KOW7. It folds into a β-barrel with an SH3-like topology. Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminal. Spt5 is involved in transcription elongation and termination. The KOW dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23038"
] | [
"KOW6_SPT51-2"
] | [
884
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005458",
"PUB00061569",
"PUB00092162",
"PUB00092163",
"PUB00092166"
] | [
"8987397",
"20197319",
"22982195",
"22306403",
"21467036"
] | [
"KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins.",
"Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.",
"The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation.",
"A nexus for gene expression-molecular mech... | [
1996,
2010,
2013,
2012,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
884
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
6,
20
] | 3 | true | Domain | Spt5, KOW domain repeat 6, plant | Spt5, KOW domain repeat 6, plant | KOW_Spt5_6_plant | 8 |
IPR057936 | 57,936 | Spt5, KOWx domain | KOWx_Spt5 | Domain | 5,569 | false | false | This entry represents the KOWx domain that is located between domains KOW3 and KOW4. The KOWx domain along with KOW4 and KOW5 forms an RNA clamp [ ]. The tandem KOWx-4 contacts the wall, stalk, and dock domains of Pol II [ ]. Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminal. Spt5 is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23037"
] | [
"KOWx_SPT5"
] | [
5569
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-112382",
"R-CEL-113418",
"R-CEL-674695",
"R-CEL-6796648",
"R-CEL-72086",
"R-CEL-75955",
"R-CEL-77075",
"R-DME-112382",
"R-DME-113418",
"R-DME-674695",
"R-DME-6796648",
"R-DME-6807505",
"R-DME-72086",
"R-DME-75955",
"R-DME-77075",
"R-DRE-674695",
"R-DRE-6796648",
"R-DRE-72086... | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-113418",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6796648",
"REACTOME:R-CEL-72086",
"REACTOME:R-CEL-75955",
"REACTOME:R-CEL-77075",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-113418",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6796648",
"REACTOME:R-DME-6807... | 55 | [
"5oho",
"5oik",
"5xon",
"6eqy",
"6gmh",
"6gml",
"6ir9",
"6j4w",
"6j4x",
"6j4y",
"6j4z",
"6j50",
"6j51",
"6ted",
"7nkx",
"7nky",
"7okx",
"7oky",
"7ol0",
"7pks",
"7unc",
"7und",
"7wbv",
"7wbw",
"7wbx",
"7xn7",
"7xse",
"7xsx",
"7xsz",
"7xt7",
"7xtd",
"7xti"... | 73 | [
"PUB00005458",
"PUB00061569",
"PUB00092162",
"PUB00092163",
"PUB00092166",
"PUB00155699"
] | [
"8987397",
"20197319",
"22982195",
"22306403",
"21467036",
"28892040"
] | [
"KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins.",
"Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.",
"The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation.",
"A nexus for gene expression-molecular mech... | [
1996,
2010,
2013,
2012,
2011,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
5568,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
5,
1,
4,
1,
1,
3,
4,
1,
1,
51
] | 12 | true | Domain | Spt5, KOWx domain | Spt5, KOWx domain | KOWx_Spt5 | 7 |
IPR057937 | 57,937 | Transcription regulator HVO_2718-like, helix-turn-helix domain | HVO_2718-like_HTH | Domain | 330 | false | false | This entry represents the C-terminal helix-turn-helix domain from a family of archaeal transcription regulators, including HVO_2718 from Haloferax volcanii ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24250"
] | [
"HVO_2718"
] | [
330
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR001387"
] | [] | 1 | 0 | 1 | [
"Methanobacteriati",
"Salinisphaera"
] | [
326,
4
] | 2 | [] | [] | 0 | true | Domain | Transcription regulator HVO_2718-like, helix-turn-helix domain | Transcription regulator HVO_2718-like, helix-turn-helix domain | HVO_2718-like_HTH | 7 |
IPR057938 | 57,938 | TreTu toxin, C-terminal domain | TreTu_C | Domain | 278 | false | false | This entry represents the C-terminal domain of TreTu from Salmonella enterica and related bacterial proteins. TreTu is a part of the TreTu/TriTu toxin/antitoxin system and is involved in the ADP-ribosylation of the EF-Tu GTP-bound form. The C-terminal domain of TreTu adopts a typical ADP-ribosyltransferase fold. The Tr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24691"
] | [
"TreTu_C"
] | [
278
] | 1 | [] | [] | [] | 0 | [
"7zhl",
"7zhm"
] | 2 | [
"PUB00155886"
] | [
"36484105"
] | [
"Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
277,
1
] | 2 | [] | [] | 0 | true | Domain | TreTu toxin, C-terminal domain | TreTu toxin, C-terminal domain | TreTu_C | 9 |
IPR057939 | 57,939 | TRF2/HOY1, PH-like domain | TRF2_HOY1_PH | Domain | 4,073 | false | false | This domain is found in Pyriculol/pyriculariol biosynthesis cluster transcription factor 1 (TRF2), Homeobox protein HOY1 (HOY1) and uncharacterised proteins mainly from plants and fungi. TRF2 is a transcription regulator which negatively regulates the expression of a gene cluster responsible for the biosynthesis of pyr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24818"
] | [
"PH_TRF2_HOY1"
] | [
4073
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098879"
] | [
"27902426"
] | [
"Unravelling the biosynthesis of pyriculol in the rice blast fungus Magnaporthe oryzae."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4073
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
1,
15,
18
] | 4 | true | Domain | TRF2/HOY1, PH-like domain | TRF2/HOY1, PH-like domain | TRF2_HOY1_PH | 5 |
IPR057940 | 57,940 | Tri-helical domain | Tri-helical_dom | Domain | 911 | false | false | This domain is found in a group of uncharacterised fungal proteins, including from Aspergillus niger. This domain, which is often found C-terminal to , is predicted to adopt a tri-helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24465"
] | [
"Tri-helical"
] | [
911
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
911
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Tri-helical domain | Tri-helical domain | Tri-helical_dom | 6 |
IPR057941 | 57,941 | Transportin-3/Importin-13, second TPR domain | TPR_TNPO3_IPO13_2nd | Repeat | 6,690 | false | false | This entry represents the second TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10 and uncharacterised protein YNR7 from yeast and MOS14 from plant. This entry also includes Importin-13 (IPO3) from animals. This domain is involved in the binding to the globular Ran protein in TNOP3 [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24138"
] | [
"TPR_TNPO3_IPO13_2nd"
] | [
6690
] | 1 | [] | [] | [] | 0 | [
"2x19",
"2xwu",
"3zjy",
"4c0o",
"4c0p",
"4c0q",
"4ol0",
"6gx9",
"8cmk"
] | 9 | [
"PUB00067136",
"PUB00130144",
"PUB00155879",
"PUB00155880",
"PUB00155881"
] | [
"23435562",
"12628928",
"24449914",
"24915079",
"21139563"
] | [
"Structural basis for the nuclear export activity of Importin13.",
"A novel splicing regulator shares a nuclear import pathway with SR proteins.",
"Structural basis for nuclear import of splicing factors by human Transportin 3.",
"Structure of transportin SR2, a karyopherin involved in human disease, in compl... | [
2013,
2003,
2014,
2014,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6690
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
6,
3,
6,
6,
1,
4,
16,
1,
1,
22
] | 12 | true | Repeat | Transportin-3/Importin-13, second TPR domain | Transportin-3/Importin-13, second TPR domain | TPR_TNPO3_IPO13_2nd | 6 |
IPR057942 | 57,942 | Transportin-3/Importin-13, third TPR domain | TPR_TNPO3_IPO13_3rd | Repeat | 6,597 | false | false | This entry represents the third TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10 and uncharacterised protein YNR7 from yeast and MOS14 from plants. This entry also includes Importin-13 (IPO3) from animals. This domain is part of TPR structure that binds proteins for nuclear transport... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24140"
] | [
"TPR_TNPO3_IPO13_3rd"
] | [
6597
] | 1 | [] | [] | [] | 0 | [
"2x19",
"2xwu",
"3zjy",
"4c0o",
"4c0p",
"4c0q",
"4ol0",
"6gx9",
"8cmk"
] | 9 | [
"PUB00067136",
"PUB00130144",
"PUB00155879",
"PUB00155880",
"PUB00155881"
] | [
"23435562",
"12628928",
"24449914",
"24915079",
"21139563"
] | [
"Structural basis for the nuclear export activity of Importin13.",
"A novel splicing regulator shares a nuclear import pathway with SR proteins.",
"Structural basis for nuclear import of splicing factors by human Transportin 3.",
"Structure of transportin SR2, a karyopherin involved in human disease, in compl... | [
2013,
2003,
2014,
2014,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6597
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
2,
5,
1,
8,
6,
3,
3,
17,
1,
1,
11
] | 12 | true | Repeat | Transportin-3/Importin-13, third TPR domain | Transportin-3/Importin-13, third TPR domain | TPR_TNPO3_IPO13_3rd | 3 |
IPR057944 | 57,944 | TSTD2, N-terminal domain | TSTD2_N | Domain | 832 | false | false | This entry represents the N-terminal domain found in TSTD2 (thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2). TSTD2 is involved in the transfer of sulphur from thiosulfate to cyanide, forming thiocyanate. It plays a role in cyanide detoxification and sulphur metabolism. The rhodanese-like domai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23949"
] | [
"TSTD2_N"
] | [
832
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160865"
] | [
"37114071"
] | [
"Low Expression of TSTD2 Serves as a Biomarker for Poor Prognosis in Kidney Renal Clear Cell Carcinoma."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
832
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
3,
4
] | 4 | true | Domain | TSTD2, N-terminal domain | TSTD2, N-terminal domain | TSTD2_N | 9 |
IPR057945 | 57,945 | ZSWIM8, TPR repeats | TPR_ZSWIM8 | Domain | 2,477 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found in human Zinc finger SWIM domain-containing protein 8 (ZSWIM8) and similar proteins mainly found in animals. ZSWIM8 is a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TD... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25572"
] | [
"TPR_ZSWIM8"
] | [
2477
] | 1 | [
"REACTOME"
] | [
"R-HSA-9010553"
] | [
"REACTOME:R-HSA-9010553"
] | 1 | [] | 0 | [
"PUB00151678",
"PUB00151679"
] | [
"33184237",
"33184234"
] | [
"The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.",
"A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming."
] | [
2020,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2477
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
6,
2,
4
] | 6 | true | Domain | ZSWIM8, TPR repeats | ZSWIM8, TPR repeats | TPR_ZSWIM8 | 9 |
IPR057946 | 57,946 | ZFYVE26-like, TPR repeats | TPR_ZFYVE26 | Domain | 2,265 | false | false | This region of tetratricopeptide (TPR)-like repeats is found in ZFYVE26 and similar proteins mainly found in animals. Zinc finger FYVE domain-containing protein 26 (ZFYVE26, also known as SPG15) is a phosphatidylinositol 3-phosphate-binding protein recruited to the midbody during cytokinesis and required for the abciss... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25569"
] | [
"TPR_ZFYVE26"
] | [
2265
] | 1 | [] | [] | [] | 0 | [
"8yad"
] | 1 | [
"PUB00067710",
"PUB00069101",
"PUB00069102",
"PUB00069103"
] | [
"20613862",
"20208530",
"18394578",
"19084844"
] | [
"A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.",
"PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.",
"Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated a... | [
2010,
2010,
2008,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2265
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
4,
1,
5,
1,
4,
3,
5
] | 8 | true | Domain | ZFYVE26-like, TPR repeats | ZFYVE26-like, TPR repeats | TPR_ZFYVE26 | 5 |
IPR057947 | 57,947 | Exportin-7/Ran-binding protein 17, TPR domain | TPR_XPO7/RBP17 | Domain | 5,135 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found in human Exportin-7 (XPO7, also known as RAN binding protein 16), Ran-binding protein 17 (RBP17) and similar eukaryotic proteins. XPO7 mediates the nuclear export of proteins with broad substrate specificity [ , ]. Exportins bind cargo molecules in the nucl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25795"
] | [
"TPR_XPO7"
] | [
5135
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090434",
"PUB00090435",
"PUB00095478",
"PUB00160708",
"PUB00160866"
] | [
"29748336",
"15282546",
"16449645",
"27306458",
"11024021"
] | [
"Xpo7 is a broad-spectrum exportin and a nuclear import receptor.",
"Exportin 7 defines a novel general nuclear export pathway.",
"The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.",
"Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A... | [
2018,
2004,
2006,
2016,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5135
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
3,
6,
10,
9,
5,
9,
37
] | 9 | true | Domain | Exportin-7/Ran-binding protein 17, TPR domain | Exportin-7/Ran-binding protein 17, TPR domain | TPR_XPO7/RBP17 | 2 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.