LiteFold/InterPro · Datasets at Hugging Face

IPR059217

59,217

LA_3751/LA_3752-like, putative

LA3751_2-like

Family

533

false

Members of this family of uncharacterised membrane proteins, averaging over 500 amino acids in length, occur primarily in Leptospira species. Four paralogs are encoded in Leptospira interrogans serovar Lai str. 56601, including tandem proteins LA_3751 ( ), LA_3752 ( ), and LA_3753 ( ), which are putative glycosyltransf...

[]

0

[ "NCBIFAM" ]

[ "NF047440" ]

[ "LA3751_2_3_fam" ]

[ 533 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 533 ]

1

[]

0

true

Family

LA_3751/LA_3752-like, putative

LA3751_2-like

6

IPR059218

59,218

LBP_cg2779-like

Family

434

false

This entry represents a group of uncharacterised proteins from lactobacillales. Some members are annotated as LBP_cg2779 family proteins.

[]

0

[ "NCBIFAM" ]

[ "NF040507" ]

[ "LBP_cg2779_fam" ]

[ 434 ]

1

[]

0

[]

0

[ "PUB00105802" ]

[ "27510766" ]

[ "Proteomic analysis of an engineered isolate of Lactobacillus plantarum with enhanced raffinose metabolic capacity." ]

[ 2016 ]

1

[]

0

null

[ "Lactobacillaceae" ]

[ 434 ]

1

[]

0

true

Family

LBP_cg2779-like

2

IPR059219

59,219

Peroxin 8, N-terminal domain

Pex8_N

Domain

1,152

false

This domain is found towards the N-terminal end of the Peroxisomal biogenesis factor 8 protein (PEX8), Peroxisomal membrane protein PEX17 and related proteins from fungal species. PEX17 is involved in peroxisome biosynthesis. This protein is required for the import of a subset of matrix proteins into peroxisomes [ ]. P...

[]

0

[ "PFAM" ]

[ "PF26001" ]

[ "Pex8_N" ]

[ 1152 ]

1

[]

0

[ "8rqt" ]

1

[ "PUB00155361", "PUB00155362", "PUB00161724" ]

[ "23902771", "7738036", "9111320" ]

[ "Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.", "PER3, a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import.", "The peroxin Pex17p of the yeast Yarrowia lipolytica is associated peripheral...

[ 2013, 1995, 1997 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1152 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Peroxin 8, N-terminal domain

Pex8_N

5

IPR059220

59,220

AbiEi antitoxin

AbiEi

Family

523

false

This family of uncharacterised proteins includes AbiEi, the antitoxin of a Type IV toxin-antitoxin mechanism from Streptococcus agalactiae [ , ], and similar sequences mainly found in proteobacteria.

[]

0

[ "NCBIFAM" ]

[ "NF047376" ]

[ "TAA_AbiEi" ]

[ 523 ]

1

[]

0

[]

0

[ "PUB00075538", "PUB00085224", "PUB00159257" ]

[ "24465005", "23478446", "29518409" ]

[ "A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism.", "Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning.", "AbiEi Binds Cooperatively to the Type IV abiE Toxin-Antitoxin Operator Via a Positively-Charged Surface and Causes DN...

[ 2014, 2013, 2018 ]

3

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 520, 3 ]

2

[]

0

true

Family

AbiEi antitoxin

AbiEi

5

IPR059221

59,221

Hypothetical fimbrial protein

Hypothethical_fimbrial

Family

285

false

This entry represents a family of proteins found in gammaproteobacteria and probably distantly related to known fimbrial proteins.

[]

0

[ "NCBIFAM" ]

[ "NF011829" ]

[ "PRK15301.1" ]

[ 285 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacterales", "Eukaryota" ]

[ 283, 2 ]

2

[]

0

true

Family

Hypothetical fimbrial protein

Hypothethical_fimbrial

6

IPR059223

59,223

DVU0772-like

Family

201

false

This entry represents a group of uncharacterised bacterial proteins, including DVU0772 from Nitratidesulfovibrio vulgaris ( ).

[]

0

[ "NCBIFAM" ]

[ "NF045682" ]

[ "DVU0772_fam" ]

[ 201 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 197, 4 ]

2

[]

0

true

Family

DVU0772-like

9

IPR059225

59,225

BspC

Family

583

false

This entry represents BspC from Brucella abortus and a number of closely related bacterial pathogens. It is a type VI secretion system (T4SS) effector [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047384" ]

[ "BspC_dom" ]

[ 583 ]

1

[]

0

[]

0

[ "PUB00159109" ]

[ "23950720" ]

[ "Brucella modulates secretory trafficking via multiple type IV secretion effector proteins." ]

[ 2013 ]

1

[]

0

null

[ "Linnemannia gamsii", "Pseudomonadota" ]

[ 2, 581 ]

2

[]

0

true

Family

BspC

4

IPR059227

59,227

Inner membrane protein YigG-like

YigG-like

Family

197

false

This entry represents a group of uncharacterised proteins from enterobacterales, including Inner membrane protein YigG from Escherichia coli.

[]

0

[ "NCBIFAM" ]

[ "NF008474" ]

[ "PRK11371.1" ]

[ 197 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacteriaceae" ]

[ 197 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YigG-like

YigG-like

7

IPR059228

59,228

Integral membrane protein, putative

Integral_mb_put

Family

126

false

This entry represents a group of small, highly hydrophobic uncharacterised proteins from actinomycetes. Members show some sequence similarity to the envelope stress response protein PspG found in some proteobacteria. In some members, it occurs as a tail domain attached to dihydrofolate reductases.

[]

0

[ "NCBIFAM" ]

[ "NF038396" ]

[ "" ]

[ 126 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Micrococcaceae" ]

[ 126 ]

1

[]

0

true

Family

Integral membrane protein, putative

Integral_mb_put

8

IPR059229

59,229

TM7SF3-like, N-terminal immunoglobulin-like domain

Ig_TM7SF3_N

Domain

1,447

false

This domain is found at the N-terminal end of human Transmembrane 7 superfamily member 3 (TM7SF3) and similar animal proteins. TM7SF3 is involved in the inhibition of cytokine-induced death of pancreatic beta cells and in the promotion of insulin secretion. It acts as a pro-survival homeostatic factor that attenuates t...

[]

0

[ "PFAM" ]

[ "PF25992" ]

[ "Ig_TM7SF3_N" ]

[ 1447 ]

1

[]

0

[]

0

[ "PUB00093040", "PUB00093041" ]

[ "27740623", "21853325" ]

[ "TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.", "An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic b...

[ 2017, 2011 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1447 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4, 4 ]

4

true

Domain

TM7SF3-like, N-terminal immunoglobulin-like domain

Ig_TM7SF3_N

2

IPR059230

59,230

Plasmid stabilization protein StbC

StbC

Family

154

false

This entry represents a group of uncharacterised proteins mainly from enterobacterales, including StbC, which is part of the stb operon, a plasmid maintenance system found in some bacterial plasmids [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041291" ]

[ "StbC" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00106299" ]

[ "21625564" ]

[ "The stb operon balances the requirements for vegetative stability and conjugative transfer of plasmid R388." ]

[ 2011 ]

1

[]

0

null

[ "Plasmid pKM101", "Pseudomonadota" ]

[ 1, 153 ]

2

[]

0

true

Family

Plasmid stabilization protein StbC

StbC

7

IPR059231

59,231

Pinensi, lanthipeptide leader domain

Leader_pinensin

Domain

143

false

This class I lanthipeptide leader peptide domain occurs in Gram-negative bacteria such as Chitinophaga pinensis (for which pinensins, antifungal lantibiotics, are named). Most member sequences contain the motif SFVT, and the leader peptide ends with a typical GlyGly motif.

[]

0

[ "NCBIFAM" ]

[ "NF038180" ]

[ "leader_pinensin" ]

[ 143 ]

1

[]

0

[]

0

[ "PUB00105595" ]

[ "26211520" ]

[ "Pinensins: the first antifungal lantibiotics." ]

[ 2015 ]

1

[]

0

null

[ "Anaeramoeba ignava", "FCB group" ]

[ 1, 142 ]

2

[]

0

true

Domain

Pinensi, lanthipeptide leader domain

Leader_pinensin

4

IPR059232

59,232

Outer membrane homotrimeric porin, putative

Porin_put

Family

315

false

This entry represents a group of uncharacterised predicted porins from thermodesulfobacteriota. Proteins of this family form transmembrane pores for the passive transport of small molecules across the outer membranes of Gram-negative bacteria.

[]

0

[ "NCBIFAM" ]

[ "NF033939" ]

[ "DESULF_POR1" ]

[ 315 ]

1

[]

0

[]

0

[ "PUB00105445" ]

[ "28874410" ]

[ "Identification and Characterization of the Major Porin of Desulfovibrio vulgaris Hildenborough." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 302, 13 ]

2

[]

0

true

Family

Outer membrane homotrimeric porin, putative

Porin_put

6

IPR059233

59,233

Serine/threonine protein kinases NdrA/B/Cbk1, Mob-binding domain

MobB_NdrA/B/Cbk1

Domain

4,972

false

This entry corresponds to the NTR or Mob-binding domain of the serine/threonine protein kinases NdrA/B and Cbk1. Proteins in this group are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. These kinases bind to highly con...

[]

0

[ "CDD" ]

[ "cd21742" ]

[ "MobB_NDR_LATS-like" ]

[ 4972 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-DDI-9013418", "R-DDI-9013422" ]

[ "EC:2.7.11.1", "REACTOME:R-DDI-9013418", "REACTOME:R-DDI-9013422" ]

3

[]

0

[ "PUB00119232", "PUB00148521", "PUB00148522", "PUB00148552", "PUB00148553" ]

[ "15308672", "26108669", "27335147", "25966461", "32250593" ]

[ "Neuronal functions of the novel serine/threonine kinase Ndr2.", "Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.", "Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathway.", "The Structure of an NDR/LATS Kinase-Mob Complex Reveal...

[ 2004, 2015, 2016, 2015, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4972 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 13, 51 ]

3

true

Domain

Serine/threonine protein kinases NdrA/B/Cbk1, Mob-binding domain

MobB_NdrA/B/Cbk1

7

IPR059235

59,235

PC-esterase domain-containing protein 1A domain

Pced1a_dom

Domain

202

false

This entry represents a domain found in a group of uncharacterised proteins from mammals, including human PC-esterase domain-containing protein 1A (Pced1). Members of this group belong to the SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is subs...

[]

0

[ "CDD" ]

[ "cd01842" ]

[ "SGNH_hydrolase_like_5" ]

[ 202 ]

1

[]

0

[]

0

[ "PUB00005440" ]

[ "7610479" ]

[ "A new family of lipolytic enzymes?" ]

[ 1995 ]

1

[]

0

null

[ "Deuterostomia" ]

[ 202 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2 ]

4

true

Domain

PC-esterase domain-containing protein 1A domain

Pced1a_dom

7

IPR059237

59,237

Geminin coiled-coil domain-containing protein 1, central coiled-coil domain

GemC1_CC

Domain

780

false

This entry represents the central coiled-coil domain of Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. This entry is specific to vertebrates. GemC1 binds to geminin an...

[]

0

[ "CDD" ]

[ "cd22588" ]

[ "GemC1_CC" ]

[ 780 ]

1

[]

0

[]

0

[ "PUB00145502", "PUB00145503", "PUB00145504", "PUB00145506", "PUB00145507", "PUB00145509" ]

[ "31328313", "26527144", "26882546", "30824354", "31028178", "26933123" ]

[ "GemC1 is a critical switch for neural stem cell generation in the postnatal brain.", "The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.", "GemC1 controls multiciliogenesis in the airway epithelium.", "Adult Neural Stem Cells and Multiciliated Ependyma...

[ 2019, 2015, 2016, 2019, 2019, 2016 ]

6

[]

0

null

[ "Gnathostomata" ]

[ 780 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4 ]

4

true

Domain

Geminin coiled-coil domain-containing protein 1, central coiled-coil domain

GemC1_CC

6

IPR059238

59,238

UBX domain protein 9, Ubiquitin regulatory domain X 1

UBX1_UBXN9

Domain

2,388

false

This entry represents the Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar animal proteins. UBXN9, also termed tether containing UBX domain for GLUT4 (TUG), or alveolar soft part sarcoma chromosomal region candidate gene 1 protein (ASPSCR1), or alveolar soft par...

[]

0

[ "CDD" ]

[ "cd17075" ]

[ "UBX1_UBXN9" ]

[ 2388 ]

1

[ "REACTOME" ]

[ "R-HSA-1445148" ]

[ "REACTOME:R-HSA-1445148" ]

1

[]

0

[ "PUB00018088", "PUB00114746", "PUB00114781", "PUB00114782", "PUB00114783", "PUB00114784", "PUB00114786", "PUB00114787" ]

[ "11243799", "18438607", "22610098", "23744065", "25561724", "25944897", "25078495", "22207755" ]

[ "The UBX domain: a widespread ubiquitin-like module.", "UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97.", "Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.", "Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal...

[ 2001, 2008, 2012, 2013, 2015, 2015, 2014, 2012 ]

8

[]

0

null

[ "Eukaryota" ]

[ 2388 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 5, 7, 8 ]

6

true

Domain

UBX domain protein 9, Ubiquitin regulatory domain X 1

UBX1_UBXN9

9

IPR059240

59,240

Excision Repair Cross Complementing 6, coiled-coil domain

CC_ERCC-6_N

Domain

1,158

false

This entry represents a coiled-coil domain located near the N terminus of human Excision Repair Cross Complementing 6 (ERCC-6, [ ]) and related proteins mainly found in animals. This coiled-coil domain binds magnesium [ , , ]. This entry does not include Saccharomyces cerevisiae RAD26, and Schizosaccharomyces pombe Rhp...

[]

0

[ "CDD" ]

[ "cd21397" ]

[ "cc_ERCC-6_N" ]

[ 1158 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427389", "R-HSA-5250924", "R-HSA-6781823", "R-HSA-6781827", "R-HSA-6782135", "R-HSA-6782210", "R-HSA-73762", "R-MMU-5250924", "R-MMU-6781823", "R-MMU-6782135", "R-MMU-6782210", "R-MMU-73762" ]

[ "REACTOME:R-HSA-427389", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-6781823", "REACTOME:R-HSA-6781827", "REACTOME:R-HSA-6782135", "REACTOME:R-HSA-6782210", "REACTOME:R-HSA-73762", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-6781823", "REACTOME:R-MMU-6782135", "REACTOME:R-MMU-6782210", "REACTOME:R...

12

[ "4cvo", "7oo3", "7oob", "7oop", "7opc", "7opd", "8b3d", "8b3f", "9bz0", "9er2", "9fd2", "9hwg" ]

12

[ "PUB00142765", "PUB00146714", "PUB00146718", "PUB00146719", "PUB00147949", "PUB00147950", "PUB00147953", "PUB00147954", "PUB00147955", "PUB00147958", "PUB00147960", "PUB00147961", "PUB00147963", "PUB00147964" ]

[ "29168508", "24874740", "28292928", "29203878", "20301516", "2172786", "28036256", "29506668", "30174298", "31722399", "30504782", "32300177", "32355176", "29069470" ]

[ "Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.", "The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis.", "Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.", "ATM and CDK2 c...

[ 2017, 2014, 2017, 2017, 0, 1990, 2017, 2018, 2018, 2020, 2018, 2020, 2020, 2017 ]

14

[]

0

null

[ "Opisthokonta" ]

[ 1158 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 1, 3 ]

4

true

Domain

Excision Repair Cross Complementing 6, coiled-coil domain

CC_ERCC-6_N

3

IPR059242

59,242

Small ribosomal subunit protein mS23, conserved domain

mS23_dom

Domain

2,644

false

This entry represents a domain found in the mitochondrial small ribosomal subunit protein mS23 and similar sequences from eukaryotes. This region adopts a more extended conformation , [ , ].

[]

0

[ "CDD" ]

[ "cd23701" ]

[ "At1g26750" ]

[ 2644 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "3j9m", "3jd5", "5aj3", "5aj4", "5mrc", "5mre", "5mrf", "6gaw", "6gaz", "6neq", "6nf8", "6nu2", "6nu3", "6rw4", "6rw5", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6yw5", "6ywe", "6ywx", "6ywy", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse"...

95

[ "PUB00019866", "PUB00044434", "PUB00098057", "PUB00156220", "PUB00158250" ]

[ "11278769", "16823961", "28154081", "30962385", "32251374" ]

[ "Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues.", "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.", "The structure of the yeast mitochondrial ribosome.", "Structural insigh...

[ 2001, 2006, 2017, 2019, 2020 ]

5

[]

[ "IPR023611" ]

0

1

0

[ "Eukaryota" ]

[ 2644 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 2, 2, 6, 1, 3, 4, 1, 1, 5 ]

12

true

Domain

Small ribosomal subunit protein mS23, conserved domain

mS23_dom

9

IPR059243

59,243

At2g46540-like

Family

182

false

This entry represents a group of uncharacterised proteins from plants, including At2g46540 from Arabidopsis thaliana, part of the plant mitochondrial complex I [ ]

[]

0

[ "CDD" ]

[ "cd22904" ]

[ "NDUFA3_plant" ]

[ 182 ]

1

[]

0

[ "7a23", "7a24", "7aqq", "7ar8", "7arb", "8bef", "8bpx", "8bq5", "8bq6" ]

9

[ "PUB00097153", "PUB00097662", "PUB00109468", "PUB00109469", "PUB00109470", "PUB00109472", "PUB00109473" ]

[ "23527692", "33060577", "32747785", "26921811", "28797839", "26801215", "14671022" ]

[ "Mitochondrial complex I.", "Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM.", "Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.", "Structure and function of mitochondrial complex I.", "Building a complex compl...

[ 2013, 2020, 2020, 2016, 2018, 2016, 2004 ]

7

[]

0

null

[ "Embryophyta" ]

[ 182 ]

1

[ "Arabidopsis thaliana" ]

[ 3 ]

1

true

Family

At2g46540-like

5

IPR059244

59,244

BRE1 E3 ubiquitin ligase

BRE1

Domain

2,566

false

This entry represents a coiled-coil domain found in BRE1 and related proteins. BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions [ ].

[]

0

[ "PFAM" ]

[ "PF08647" ]

[ "BRE1" ]

[ 2566 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00033272" ]

[ "16337599" ]

[ "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions." ]

[ 2005 ]

1

[]

0

null

[ "Bacillota", "Eukaryota" ]

[ 2, 2564 ]

2

[ "Danio rerio", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 3, 2, 1, 1, 2 ]

6

true

Domain

BRE1 E3 ubiquitin ligase

BRE1

6

IPR059245

59,245

Centrosomal protein CEP104, TOG domain

CEP104_TOG

Domain

2,446

false

This entry represents the central tubulin-binding TOG domain, consisting of HEAT repeats [ , ]. Centrosomal protein CEP104 localises to the distal end of centrioles that interacts through its N- and C-terminal region, respectively, with the distal end proteins Cep97 and CP110 [ ]. It is required for ciliogenesis and fo...

[]

0

[ "PFAM" ]

[ "PF21040" ]

[ "CEP104_TOG" ]

[ 2446 ]

1

[]

0

[ "5jo8", "5lph" ]

2

[ "PUB00151669", "PUB00151670", "PUB00151671" ]

[ "28017521", "27402853", "32817551" ]

[ "The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase.", "Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.", "A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers." ]

[ 2017, 2016, 2020 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2446 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 11, 4, 8 ]

5

true

Domain

Centrosomal protein CEP104, TOG domain

CEP104_TOG

2

IPR059246

59,246

Uncharacterized protein C-166

C166

Family

20

false

This entry represents the Uncharacterized protein C-166 from sulfolobus spindle-shape virus 1 (SSV1) and related proteins found in Fuselloviridae. C-166 protein was proposed to play a role in the in virus assembly. This proteins is likely essential for the virus function [ ].

[]

0

[ "PFAM" ]

[ "PF17615" ]

[ "C166" ]

[ 20 ]

1

[]

0

[ "7xdi" ]

1

[ "PUB00046115" ]

[ "10430570" ]

[ "Genetic requirements for the function of the archaeal virus SSV1 in Sulfolobus solfataricus: construction and testing of viral shuttle vectors." ]

[ 1999 ]

1

[]

0

null

[ "Fuselloviridae", "Sulfolobaceae" ]

[ 10, 10 ]

2

[]

0

true

Family

Uncharacterized protein C-166

C166

1

IPR059248

59,248

SAP domain-containing new25, SAP domain

SAP_new25

Domain

274

false

This entry represents the SAP domain found in the Schizosaccharomyces pombe SAP domain-containing new25 protein and related fungal proteins [ ]. SAP (SAF-A/B, Acinus and PIAS) motif is a DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins [ ]. This fungal SAP domain may be important for DNA-related...

[]

0

[ "PFAM" ]

[ "PF18953" ]

[ "SAP_new25" ]

[ 274 ]

1

[]

0

[]

0

[ "PUB00049443", "PUB00148970" ]

[ "18831036", "21270388" ]

[ "Solution structures and DNA binding properties of the N-terminal SAP domains of SUMO E3 ligases from Saccharomyces cerevisiae and Oryza sativa.", "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability." ]

[ 2009, 2011 ]

2

[]

0

null

[ "Bacillota", "Opisthokonta" ]

[ 5, 269 ]

2

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Domain

SAP domain-containing new25, SAP domain

SAP_new25

8

IPR059249

59,249

BRSK1/2-like, KA1 domain

BRSK1_2-like_KA1

Domain

4,142

false

This entry represents the KA1-like domain found in the brain-specific kinases BRSK1, BRSK2 and SAD-1 [ , ]. BRSK1 and BRSK2 are AMP-activated protein kinase (AMPK)-related kinases that are highly expressed in mammalian forebrain and crucial for establishing neuronal polarity. BRSK1, also called brain-selective kinase 1...

[]

0

[ "PFAM" ]

[ "PF21122" ]

[ "KA1_BRSK" ]

[ 4142 ]

1

[ "EC", "EC" ]

[ "2.7.11.1", "2.7.11.26" ]

[ "EC:2.7.11.1", "EC:2.7.11.26" ]

2

[ "4yom", "5iri" ]

2

[ "PUB00063854", "PUB00130856", "PUB00131847", "PUB00131850", "PUB00131851", "PUB00131852", "PUB00152653", "PUB00152655" ]

[ "21985311", "20026642", "23029325", "22669945", "22609399", "22020259", "26626945", "27251228" ]

[ "Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.", "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.", "APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.", ...

[ 2012, 2010, 2012, 2012, 2012, 2011, 2015, 2016 ]

8

[]

0

null

[ "Eukaryota" ]

[ 4142 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 43, 4, 10, 11, 8 ]

6

true

Domain

BRSK1/2-like, KA1 domain

BRSK1_2-like_KA1

8

IPR059250

59,250

TMEM164-like

Family

5,574

false

This entry represents a family of integral membrane proteins. In eukaryotes this protein is known as TMEM164, which is a positive regulator of ferroptosis [ , ], but it is also widely distributed in bacteria. Proteins in this family are typically between 200 to 300 amino acids in length. The protein contains several co...

[]

0

[ "PFAM" ]

[ "PF14808" ]

[ "TMEM164" ]

[ 5574 ]

1

[]

0

[]

0

[ "PUB00151897", "PUB00161763" ]

[ "35947500", "36782012" ]

[ "TMEM164 is a new determinant of autophagy-dependent ferroptosis.", "TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids." ]

[ 2023, 2023 ]

2

[]

[ "IPR011737", "IPR026508" ]

0

2

0

[ "Bacteria", "Eukaryota", "Nitrososphaerota", "metagenomes" ]

[ 3567, 1930, 2, 75 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 1, 2, 7, 4 ]

6

true

Family

TMEM164-like

9

IPR059251

59,251

Glycan binding domain, putative

Fungal_lectin_2

Domain

669

false

This domain is found in uncharacterised fungal proteins. It is predicted to fold into an α/β structure with a significant similarity to domains members of Yeast killer toxin-like superfamily. This domain contains several conserved cysteine residues which similarly to other members of this superfamily are probably invol...

[]

0

[ "PFAM" ]

[ "PF18647" ]

[ "Fungal_lectin_2" ]

[ 669 ]

1

[]

0

[]

0

[ "PUB00138357" ]

[ "25504801" ]

[ "Atomic-resolution structure of the α-galactosyl binding Lyophyllum decastes lectin reveals a new protein family found in both fungi and plants." ]

[ 2015 ]

1

[]

0

null

[ "Fungi" ]

[ 669 ]

1

[]

0

true

Domain

Glycan binding domain, putative

Fungal_lectin_2

7

IPR059252

59,252

Positive regulator of sigma(E), RseC/MucC-like

RseC_MucC-like

Family

5,300

false

This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cell...

[]

0

[ "PFAM" ]

[ "PF04246" ]

[ "RseC_MucC" ]

[ 5300 ]

1

[]

0

[]

0

[ "PUB00009919", "PUB00009920", "PUB00020279" ]

[ "9159522", "9335303", "8264535" ]

[ "Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins.", "Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium.", "Identification of a new class of nitrogen fixation genes in Rhodobacte...

[ 1997, 1997, 1993 ]

3

[]

[ "IPR007359" ]

0

1

0

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5168, 3, 129 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Positive regulator of sigma(E), RseC/MucC-like

RseC_MucC-like

1

IPR059253

59,253

Protein unc-79 homolog, N-terminal

UNC-79_N

Domain

2,600

false

This entry represents the N-terminal region of Protein unc-79 homolog from Homo sapiens and related proteins. It is composed of α-helical HEAT repeats in which are inserted very two small α/β substructures. This domain is absent in the Uncoordinated protein 79 (UNC79) from C.elegans. The Protein unc-79 homolog is an au...

[]

0

[ "PFAM" ]

[ "PF14776" ]

[ "UNC-79" ]

[ 2600 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2672351", "R-MMU-2672351" ]

[ "REACTOME:R-HSA-2672351", "REACTOME:R-MMU-2672351" ]

2

[ "7sx3", "7sx4", "7w7g", "7wji" ]

4

[ "PUB00068623", "PUB00069388", "PUB00075911", "PUB00152417", "PUB00161728" ]

[ "9671752", "19092807", "18336069", "20714347", "32620897" ]

[ "Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans.", "Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.", "A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.", "Conserved role...

[ 1998, 2009, 2008, 2010, 2020 ]

5

[]

0

null

[ "Metazoa" ]

[ 2600 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 7, 4, 6, 6 ]

6

true

Domain

Protein unc-79 homolog, N-terminal

UNC-79_N

9

IPR059255

59,255

CFAP74, first Ig-like domain

Ig_CFAP74_1st

Domain

1,401

false

This entry represents the first Ig-like domain of CFAP74, a protein that is part of the central apparatus of the cilium axoneme and may play a role in cilium movement. It may play an important role in sperm architecture and function [ ].

[]

0

[ "PFAM" ]

[ "PF24771" ]

[ "Ig_CFAP74_1st" ]

[ 1401 ]

1

[]

0

[ "7n6g", "7sqc", "9ijj" ]

3

[ "PUB00155666" ]

[ "32555313" ]

[ "Biallelic mutations of CFAP74 may cause human primary ciliary dyskinesia and MMAF phenotype." ]

[ 2020 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1401 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 3, 5 ]

4

true

Domain

CFAP74, first Ig-like domain

Ig_CFAP74_1st

9

IPR059256

59,256

RIC1, second beta-propeller domain

Beta-prop_RIC1_2nd

Domain

4,940

false

This entry represents the second β-propeller domain found in RIC1 (Ribosome control protein 1) proteins. This domain is consistently found C-terminal to another β-propeller domain in RIC1 proteins from species ranging from yeast to humans. RIC1 proteins form a complex with RGP1 that functions as a guanine nucleotide ex...

[]

0

[ "PFAM" ]

[ "PF25440" ]

[ "Beta-prop_RIC1_2nd" ]

[ 4940 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6811438", "R-CEL-6811440", "R-CEL-8876198", "R-DME-6811440", "R-DME-8876198", "R-DRE-6811438", "R-HSA-6811438", "R-HSA-6811440", "R-HSA-8876198", "R-MMU-6811438", "R-MMU-6811440", "R-MMU-8876198", "R-SCE-6811440", "R-SCE-8876198", "R-SPO-6811440", "R-SPO-8876198" ]

[ "REACTOME:R-CEL-6811438", "REACTOME:R-CEL-6811440", "REACTOME:R-CEL-8876198", "REACTOME:R-DME-6811440", "REACTOME:R-DME-8876198", "REACTOME:R-DRE-6811438", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-6811438", "REACTOME:R-MMU-6811440", "REACTOM...

16

[ "9ayr" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4940 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 2, 1, 2, 3, 1, 3, 4, 1, 1, 56 ]

12

true

Domain

RIC1, second beta-propeller domain

Beta-prop_RIC1_2nd

3

IPR059257

59,257

Spike protein P1, second jelly-roll domain

Spike_JR2

Domain

5

false

This entry represents the second jelly-roll domain of Spike protein P1 from Pseudoalteromonas phage PM2 and related prophages [ , , ]. The Spike protein P1, also known as Protein I, is a key component of the Pseudoalteromonas phage PM2 (Bacteriophage PM2). This protein is responsible for receptor binding and is located...

[]

0

[ "PFAM" ]

[ "PF22465" ]

[ "Spike_JR2" ]

[ 5 ]

1

[]

0

[ "2vve", "2w0c" ]

2

[ "PUB00049918", "PUB00161734", "PUB00161735" ]

[ "18775333", "17634101", "29798916" ]

[ "Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2.", "Putative prophages related to lytic tailless marine dsDNA phage PM2 are widespread in the genomes of aquatic bacteria.", "Genome Sequence of PM2-Like Phage Cr39582, Induced from a Pseud...

[ 2008, 2007, 2018 ]

3

[]

0

null

[ "Pseudoalteromonas", "Pseudoalteromonas phage PM2" ]

[ 4, 1 ]

2

[]

0

true

Domain

Spike protein P1, second jelly-roll domain

Spike_JR2

6

IPR059258

59,258

Transcription factor NusA, bacteria

NusA_bact

Family

24,737

false

This entry represents NusA in bacterial proteins. NusA is involved in transcriptional pausing, termination and anti-termination. NusA from Thermotoga maritima contains an N-terminal domain and three RNA-binding domains (one S1 domain and two KH domains ). The N-terminal domain consists of a bifurcated coiled β-sheet wi...

[]

0

[ "HAMAP" ]

[ "MF_00945_B" ]

[ "NusA_B" ]

[ 24737 ]

1

[]

0

[ "1hh2", "1k0r", "1l2f", "4mtn", "5lm7", "5lm9", "5ms0", "6flq", "6gov", "6j9e", "6tqn", "6tqo", "6x6t", "6x7f", "6x7k", "6x9q", "6xas", "6xav", "6xdq", "6z9p", "6z9q", "6z9r", "6z9s", "6z9t", "7adb", "7adc", "7add", "7ade", "7py3", "7py5", "7py6", "7py7"...

61

[ "PUB00026894" ]

[ "14621988" ]

[ "Crystal structure of NusA from Thermotoga maritima and functional implication of the N-terminal domain." ]

[ 2003 ]

1

[ "IPR030842" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24241, 58, 438 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription factor NusA, bacteria

NusA_bact

3

IPR059259

59,259

HetR, N-terminal domain

HetR_N

Domain

364

false

This is the N-terminal domain found in Heterocyst differentiation control protein (HetR). HetR serine peptidases are associated with heterocystous cyanobacteria and belong to MEROPS peptidase family S48 (clan S-). HetR is a DNA-binding serine-type protease required for heterocyst differentiation in heterocystous cyanob...

[]

0

[ "PFAM" ]

[ "PF03574" ]

[ "Peptidase_S48" ]

[ 364 ]

1

[ "EC", "METACYC" ]

[ "3.4.21.-", "PWY-7884" ]

[ "EC:3.4.21.-", "METACYC:PWY-7884" ]

2

[ "3qod", "3qoe", "4hri", "4izz", "4j00", "4j01", "4yrv" ]

7

[ "PUB00044662", "PUB00044663" ]

[ "10692362", "15051891" ]

[ "Identification of the active site of HetR protease and its requirement for heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120.", "HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Cyanobacteriota" ]

[ 364 ]

1

[]

0

true

Domain

HetR, N-terminal domain

HetR_N

2

IPR059260

59,260

EndoQ-like

Family

3,171

false

This entry represents Pyrococcus furiosus EndoQ ( ) [ ] and related proteins. EndoQ is a lesion-specific endonuclease which is assumed to be involved in DNA repair pathways in Thermococcales. It recognises a deaminated base and hydrolyses the phosphodiester bond 5' to the site of the lesion. Initially identified as a h...

[]

0

[ "CDD" ]

[ "cd19067" ]

[ "PfuEndoQ-like" ]

[ 3171 ]

1

[]

0

[ "5zb8", "7k30", "7k31", "7k32", "7k33" ]

5

[ "PUB00110283", "PUB00110284", "PUB00110285", "PUB00110286", "PUB00110287" ]

[ "29660024", "25694513", "28095753", "26116888", "27150116" ]

[ "Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus.", "A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furiosus.", "A functional endonuclease Q exists in the bacterial domain: identification and characterization of endonuclease Q...

[ 2018, 2015, 2017, 2015, 2016 ]

5

[]

[ "IPR005287" ]

0

1

0

[ "Archaea", "Bacteria", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 297, 2812, 1, 61 ]

4

[]

0

true

Family

EndoQ-like

1

IPR059261

59,261

Domain of unknown function DUF8217

DUF8217

Domain

108

false

This domain is found in uncharacterised proteins from Alphaproteobacteria. It is predicted to adopt a beta- sandwich with unique topology. It contains four highly conserved cysteine residues that are predicted to form disulfide bonds.

[]

0

[ "PFAM" ]

[ "PF26654" ]

[ "DUF8217" ]

[ 108 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "hydrothermal vent metagenome" ]

[ 107, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8217

DUF8217

9

IPR059263

59,263

Domain of unknown function DUF8219

DUF8219

Domain

216

false

This domain is found in uncharacterised proteins. It has detectable similarity to members of Immunity protein 19 family and it is predicted to adopt similar structure.

[]

0

[ "PFAM" ]

[ "PF26656" ]

[ "DUF8219" ]

[ 216 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "leotiomyceta" ]

[ 181, 35 ]

2

[]

0

true

Domain

Domain of unknown function DUF8219

DUF8219

2

IPR059264

59,264

Domain of unknown function DUF8220

DUF8220

Domain

123

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an unique α/β structure composed on a four-stranded mixed β-sheet (order 2143) and α-helices that pack on one face of the sheet, spanning edge to edge.

[]

0

[ "PFAM" ]

[ "PF26665" ]

[ "DUF8220" ]

[ 123 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 123 ]

1

[]

0

true

Domain

Domain of unknown function DUF8220

DUF8220

8

IPR059265

59,265

Dynactin subunit 1, DUF8221

DUF8221

Domain

4,566

false

This entry represents a long α-helical region found in dynactin-like proteins from animals and fungi, including human Dynactin subunit 1 (DCTN1) and Dynactin and 150 kDa isoform from Neurospora crassa (DAP-150). This region may mediate oligomerisation forming a coiled-coil. Human DCTN1 plays a key role in dynein-mediat...

[]

0

[ "PFAM" ]

[ "PF26666" ]

[ "DUF8221" ]

[ 4566 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-2132295", "R-HSA-2565942", "R-HSA-3371497", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-381038", "R-HSA-5620912", "R-HSA-6807878", "R-HSA-6811436", "R-HSA-8854518", "R-HSA-9725370", "R-MMU-2132295", "R-MMU-2565942", "R-MMU-3371497", "R-MMU-380259", ...

[ "REACTOME:R-HSA-2132295", "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-3371497", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811436", "REACTOME:R-H...

45

[ "6znl", "7z8f", "8pqw", "8pqz", "8pr0", "8pr5", "8ptk", "9b7j", "9dgr", "9dgs", "9dgt", "9dgu", "9dgv" ]

13

[ "PUB00108975", "PUB00162444", "PUB00162445", "PUB00162446", "PUB00162447", "PUB00162448" ]

[ "23386061", "22327364", "23874158", "25185702", "25774020", "8744947" ]

[ "Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.", "Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.", "Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.", "Dynactin functions as ...

[ 2013, 2012, 2013, 2014, 2015, 1996 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "bird metagenome" ]

[ 6, 4559, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 16, 5, 7, 1, 12 ]

5

true

Domain

Dynactin subunit 1, DUF8221

DUF8221

6

IPR059267

59,267

Domain of unknown function DUF8223

DUF8223

Domain

658

false

This entry represents a domain found in uncharacterised plant proteins. It is predicted to fold into unique α/β structure consisting of a meander curved β-sheet and α-helices packed on one face of the sheet and sandwiched with another four-stranded small β-sheet.

[]

0

[ "PFAM" ]

[ "PF26668" ]

[ "DUF8223" ]

[ 658 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 658 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 3, 6 ]

3

true

Domain

Domain of unknown function DUF8223

DUF8223

9

IPR059268

59,268

Domain of unknown function DUF8224

DUF8224

Domain

405

false

This domain is found in uncharacterised proteins. It is predicted to fold into a globular structure consisting mainly of α-helices. It contains one histidine and two cysteine residues which are highly conserved and may be essential for function.

[]

0

[ "PFAM" ]

[ "PF26675" ]

[ "DUF8224" ]

[ 405 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Fungi", "Methanobrevibacter", "Viruses", "marine sediment metagenome" ]

[ 152, 68, 2, 181, 2 ]

5

[]

0

true

Domain

Domain of unknown function DUF8224

DUF8224

5

IPR059269

59,269

Domain of unknown function DUF8225

DUF8225

Domain

521

false

This domain is found in uncharacterised proteins. It is predicted to adopt an unique complex alpha/ beta structure. IT contains a number of conserved negatively charged residues that may be essential for function.

[]

0

[ "PFAM" ]

[ "PF26676" ]

[ "DUF8225" ]

[ 521 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 320, 201 ]

2

[]

0

true

Domain

Domain of unknown function DUF8225

DUF8225

5

IPR059270

59,270

Domain of unknown function DUF8226

DUF8226

Domain

280

false

This domain is found in uncharacterised proteins mainly from Bacteroidota. It is predicted to fold into α/β structure with unique topology. This domain is flanked by coiled coil regions.

[]

0

[ "PFAM" ]

[ "PF26677" ]

[ "DUF8226" ]

[ 280 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 280 ]

1

[]

0

true

Domain

Domain of unknown function DUF8226

DUF8226

7

IPR059271

59,271

Domain of unknown function DUF8227

DUF8227

Domain

268

false

This domain is found in uncharacterised plant proteins. It is predicted to fold into two meander beta-sheets that sandwich each other.

[]

0

[ "PFAM" ]

[ "PF26678" ]

[ "DUF8227" ]

[ 268 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fabaceae" ]

[ 268 ]

1

[]

0

true

Domain

Domain of unknown function DUF8227

DUF8227

6

IPR059273

59,273

Domain of unknown function DUF8229

DUF8229

Domain

72

false

This entry represents an uncharacterised β-sandwich domain found in a small family of uncharacterised halobacterial proteins. STRING shows that this protein is often found associated with a and an SpeE enzyme.

[]

0

[ "PFAM" ]

[ "PF26682" ]

[ "DUF8229" ]

[ 72 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 72 ]

1

[]

0

true

Domain

Domain of unknown function DUF8229

DUF8229

5

IPR059274

59,274

Domain of unknown function DUF8230

DUF8230

Domain

933

false

This entry represents a functionally uncharacterised domain that shows structural similarity to which is the sensor domain of the PknH protein kinase protein.

[]

0

[ "PFAM" ]

[ "PF26686" ]

[ "DUF8230" ]

[ 933 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 740, 171, 22 ]

3

[]

0

true

Domain

Domain of unknown function DUF8230

DUF8230

7

IPR059275

59,275

Protein of unknown function DUF8231

DUF8231

Family

252

false

This entry represents a family of uncharacterised proteins from archaebacteria. These proteins contain and N and C-terminal transmembrane α-helix. These α-helices interact with each other. The central portion of the protein is likely to form a series of extracellular domains.

[]

0

[ "PFAM" ]

[ "PF26687" ]

[ "DUF8231" ]

[ 252 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales" ]

[ 2, 250 ]

2

[]

0

true

Family

Protein of unknown function DUF8231

DUF8231

4

IPR059276

59,276

Domain of unknown function DUF8232

DUF8232

Domain

230

false

This domain is found in uncharacterised proteins mainly from dinoflagellates. It is predicted to fold into an α-helical structure. It contains several invariant residues including aspartate and cysteine that may be essential for function.

[]

0

[ "PFAM" ]

[ "PF26692" ]

[ "DUF8232" ]

[ 230 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dinophyceae" ]

[ 230 ]

1

[]

0

true

Domain

Domain of unknown function DUF8232

DUF8232

8

IPR059277

59,277

Domain of unknown function DUF8233

DUF8233

Domain

31

false

This domain is found in uncharacterised proteins from Methanobacteriati. It is predicted to fold into unusual α/β structure. AlphaFold predicts that it may form a swapped dimer.

[]

0

[ "PFAM" ]

[ "PF26694" ]

[ "DUF8233" ]

[ 31 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriaceae", "bioreactor metagenome" ]

[ 29, 2 ]

2

[]

0

true

Domain

Domain of unknown function DUF8233

DUF8233

3

IPR059278

59,278

Domain of unknown function DUF8234

DUF8234

Domain

238

false

This domain is found in uncharacterised proteins. It is predicted to fold into an α-helical structure which is usually found inserted into endonuclease domain (CL0530). It contains a highly conserved Gx(2)Rx(2)SxPDRxTN sequence motif which is predicted to face the endonuclease domain active site and is likely involved ...

[]

0

[ "PFAM" ]

[ "PF26695" ]

[ "DUF8234" ]

[ 238 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 238 ]

1

[]

0

true

Domain

Domain of unknown function DUF8234

DUF8234

8

IPR059279

59,279

Domain of unknown function DUF8235

DUF8235

Domain

239

false

This domain is found in uncharacterised proteins from betaproteobacteria. It is predicted to adopt α-helical structure. In some proteins it is found repeated.

[]

0

[ "PFAM" ]

[ "PF26699" ]

[ "DUF8235" ]

[ 239 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Betaproteobacteria", "Oryza sativa subsp. indica", "mine drainage metagenome" ]

[ 233, 1, 5 ]

3

[]

0

true

Domain

Domain of unknown function DUF8235

DUF8235

6

IPR059280

59,280

Domain of unknown function DUF8236

DUF8236

Domain

114

false

This domain is found in uncharacterised proteins. It is predicted to fold into a small open β-barrel with an α-hairpin packed on one side.

[]

0

[ "PFAM" ]

[ "PF26703" ]

[ "DUF8236" ]

[ 114 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 47, 67 ]

2

[]

0

true

Domain

Domain of unknown function DUF8236

DUF8236

5

IPR059281

59,281

Domain of unknown function DUF8237

DUF8237

Domain

297

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a globular structure with significant similarity to C-type lectin. Compared to known C-type lectin domains this domain contains a large insertion comprising a six-stranded β-meander. Some proteins contain two copies of this domain.

[]

0

[ "PFAM" ]

[ "PF26707" ]

[ "DUF8237" ]

[ 297 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 294, 3 ]

2

[]

0

true

Domain

Domain of unknown function DUF8237

DUF8237

4

IPR059283

59,283

Domain of unknown function DUF8239

DUF8239

Domain

69

false

This domain is found in uncharacterised proteins from Gram-negative bacteria. It is predicted to fold into a β-sandwich which has some similarity to known carbohydrate binding domains. It is frequently found in combination with PEP-CTERM sorting motif suggesting that it may be associated with the membrane.

[]

0

[ "PFAM" ]

[ "PF26711" ]

[ "DUF8239" ]

[ 69 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "bioreactor metagenome" ]

[ 68, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8239

DUF8239

8

IPR059284

59,284

Domain of unknown function DUF8240

DUF8240

Domain

73

false

This domain is found in uncharacterised proteins from halobacteria. It is predicted to fold into a β-barrel structure which has a similarity to Heme iron utilization protein domains. The heme binding site is not conserved. Although, structurally it is more similar to HemS/ChuS-like domains, this domain has probably und...

[]

0

[ "PFAM" ]

[ "PF26712" ]

[ "DUF8240" ]

[ 73 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 73 ]

1

[]

0

true

Domain

Domain of unknown function DUF8240

DUF8240

6

IPR059285

59,285

Domain of unknown function DUF8241

DUF8241

Domain

54

false

This domain is found in uncharacterised plant proteins. It contains three repeats with topology similar to the C-terminal domain of defensin. Each of these repeats has two predicted disulfide bonds that are conserved and occupying the same spatial position as the disulfide bonds in defensin. This domain is frequently f...

[]

0

[ "PFAM" ]

[ "PF26721" ]

[ "DUF8241" ]

[ 54 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlorophyta" ]

[ 54 ]

1

[]

0

true

Domain

Domain of unknown function DUF8241

DUF8241

4

IPR059286

59,286

Domain of unknown function DUF8242

DUF8242

Domain

46

false

This domain is found in uncharacterised fungal proteins. It is predicted to fold into an unique α/β structure composed of a small central four-stranded antiparallel β-sheet surrounded by α-helices.

[]

0

[ "PFAM" ]

[ "PF26727" ]

[ "DUF8242" ]

[ 46 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pleosporales" ]

[ 46 ]

1

[]

0

true

Domain

Domain of unknown function DUF8242

DUF8242

3

IPR059287

59,287

Domain of unknown function DUF8243

DUF8243

Domain

418

false

This domain is found in uncharacterised proteins. It contains two pairs of highly conserved cysteine residues that may coordinate a metal ion. This domain is predicted to fold into a structure that is probably distantly related to domains with beta-tent fold (CL0080). The zinc ribbon in this domain is grafted into alph...

[]

0

[ "PFAM" ]

[ "PF26731" ]

[ "DUF8243" ]

[ 418 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 147, 271 ]

2

[]

0

true

Domain

Domain of unknown function DUF8243

DUF8243

3

IPR059288

59,288

Protein of unknown function DUF8244

DUF8244

Family

39

false

This entry describes a set of proteins of unknown function, mainly from Dictyostelium sp. These uncharacterised proteins display a CUB-like fold, a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins [ ].

[]

0

[ "PFAM" ]

[ "PF26736" ]

[ "DUF8244" ]

[ 39 ]

1

[]

0

[]

0

[ "PUB00035659" ]

[ "17446170" ]

[ "Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity." ]

[ 2007 ]

1

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 13, 26 ]

2

[]

0

true

Family

Protein of unknown function DUF8244

DUF8244

5

IPR059289

59,289

Domain of unknown function DUF8245

DUF8245

Domain

333

false

This domain is found in uncharacterised proteins from gram-negative bacteria. It contains highly conserved histidine and three cysteine residues arranged in HCCC pattern. These residues are predicted to be located in proximity and likely to coordinate a metal ion. This domain is usually found preceding HNH nuclease dom...

[]

0

[ "PFAM" ]

[ "PF26739" ]

[ "DUF8245" ]

[ 333 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 326, 7 ]

2

[]

0

true

Domain

Domain of unknown function DUF8245

DUF8245

9

IPR059290

59,290

Domain of unknown function DUF8246

DUF8246

Domain

1,294

false

This domain is found in the uncharacterised protein At4g37920 from Arabidopsis thaliana and similar proteins. This domain is predicted to adopt an all-α configuration. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF26740" ]

[ "DUF8246" ]

[ 1294 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Levilinea saccharolytica" ]

[ 1293, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 9, 10 ]

3

true

Domain

Domain of unknown function DUF8246

DUF8246

2

IPR059291

59,291

Domain of unknown function DUF8247

DUF8247

Domain

170

false

This domain is found in the uncharacterised protein ZK1098.2 from Caenorhabditis elegans and similar sequences. It is predicted to adopt an α/β configuration.

[]

0

[ "PFAM" ]

[ "PF26742" ]

[ "DUF8247" ]

[ 170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 170 ]

1

[ "Caenorhabditis elegans" ]

[ 3 ]

1

true

Domain

Domain of unknown function DUF8247

DUF8247

3

IPR059292

59,292

Domain of unknown function DUF8248

DUF8248

Domain

79

false

This domain is found in uncharacterised proteins from Gammaproteobacteria. It is predicted to adopt a structure which has similarity to SPM domain. The Ca2+ binding sites are not conserved suggesting that this domain doesn't bind Ca2+ ions. This domain is frequently found in combination with representing a group of put...

[]

0

[ "PFAM" ]

[ "PF26746" ]

[ "DUF8248" ]

[ 79 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Legionellales" ]

[ 79 ]

1

[]

0

true

Domain

Domain of unknown function DUF8248

DUF8248

8

IPR059293

59,293

Domain of unknown function DUF8249

DUF8249

Domain

60

false

This domain is found in uncharacterised eukaryotic proteins. It is predicted to fold into unique α/β structure. It has two highly conserved histidines and a serine that may have functional importance.

[]

0

[ "PFAM" ]

[ "PF26754" ]

[ "DUF8249" ]

[ 60 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 60 ]

1

[]

0

true

Domain

Domain of unknown function DUF8249

DUF8249

5

IPR059294

59,294

Domain of unknown function DUF8250

DUF8250

Domain

51

false

This domain is found in uncharacterised proteins predominantly from bacteria. It contains two pairs of conserved cysteine residues that may be involved in metal ion coordination. This domain is predicted to adopt a fold typical for zinc beta-ribbon domains.

[]

0

[ "PFAM" ]

[ "PF26757" ]

[ "DUF8250" ]

[ 51 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus phage vB_BmeM-Goe8", "Bacteria", "Noctuoidea", "termite gut metagenome" ]

[ 1, 45, 4, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF8250

DUF8250

8

IPR059295

59,295

Domain of unknown function DUF8251

DUF8251

Domain

84

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold in a β-sandwich with unique topology.

[]

0

[ "PFAM" ]

[ "PF26770" ]

[ "DUF8251" ]

[ 84 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 84 ]

1

[]

0

true

Domain

Domain of unknown function DUF8251

DUF8251

8

IPR059296

59,296

Domain of unknown function DUF8252

DUF8252

Domain

165

false

This domain is found in uncharacterised proteins. It contains several highly conserved cysteine residues that are predicted to form disulfide bonds. Some proteins contain multiple tandem copies of this domain.

[]

0

[ "PFAM" ]

[ "PF26780" ]

[ "DUF8252" ]

[ 165 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Myxococcota" ]

[ 60, 105 ]

2

[]

0

true

Domain

Domain of unknown function DUF8252

DUF8252

4

IPR059297

59,297

Repeat of unknown function DUF8253

DUF8253

Repeat

42

false

This domain is found in uncharacterised proteins mainly from Microbacteriaceae. It contains repetitive QC sequence motif frequently found in the context of NQCN motif. This domain is predicted to fold into an unique β-sandwich formed of these consecutive motifs.

[]

0

[ "PFAM" ]

[ "PF26781" ]

[ "DUF8253" ]

[ 42 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 42 ]

1

[]

0

true

Repeat

Repeat of unknown function DUF8253

DUF8253

2

IPR059298

59,298

Domain of unknown function DUF8254

DUF8254

Domain

315

false

This domain is found in uncharacterised eukaryotic proteins. It share similarity with known CHORD domains and it is predicted to adopt similar structure. In some proteins it is found in combination with AAA+ domains . It contains several cysteine and histidine residues which are highly conserved and likely involved in ...

[]

0

[ "PFAM" ]

[ "PF26782" ]

[ "DUF8254" ]

[ 315 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 315 ]

1

[]

0

true

Domain

Domain of unknown function DUF8254

DUF8254

5

IPR059299

59,299

Domain of unknown function DUF8255

DUF8255

Domain

137

false

This domain is found in uncharacterised bacterial proteins. It contains four pairs of highly conserved cysteine residues that may be involved in metal coordination. It is predicted to contain two zinc beta ribbon domains with one domain inserted into the other.

[]

0

[ "PFAM" ]

[ "PF26783" ]

[ "DUF8255" ]

[ 137 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Plasmid pLMO150", "ecological metagenomes" ]

[ 129, 1, 1, 6 ]

4

[]

0

true

Domain

Domain of unknown function DUF8255

DUF8255

4

IPR059300

59,300

Domain of unknown function DUF8256

DUF8256

Domain

33

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an unique structure composed of two meander beta-sheets that pack close.

[]

0

[ "PFAM" ]

[ "PF26784" ]

[ "DUF8256" ]

[ 33 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 33 ]

1

[]

0

true

Domain

Domain of unknown function DUF8256

DUF8256

6

IPR059301

59,301

Domain of unknown function DUF8257

DUF8257

Domain

112

false

This domain is found in uncharacterised fungal proteins. It contains two pairs of highly conserved cysteine residues that are likely involved in metal coordination. This domain is predicted to fold into a structure which closely resembles domains members of the Zn(2)-Cys(6) binuclear cluster superfamily. Despite its co...

[]

0

[ "PFAM" ]

[ "PF26785" ]

[ "DUF8257" ]

[ 112 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "leotiomyceta" ]

[ 112 ]

1

[]

0

true

Domain

Domain of unknown function DUF8257

DUF8257

6

IPR059302

59,302

Domain of unknown function DUF8258

DUF8258

Domain

146

false

This domain is found in uncharacterised insect proteins. It contains several highly conserved cysteine residues that are predicted to form disulfide bonds. Many proteins contain multiple copies of this domain.

[]

0

[ "PFAM" ]

[ "PF26786" ]

[ "DUF8258" ]

[ 146 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Polyphaga" ]

[ 146 ]

1

[]

0

true

Domain

Domain of unknown function DUF8258

DUF8258

8

IPR059304

59,304

Domain of unknown function DUF8260

DUF8260

Domain

44

false

This domain is found in uncharacterised bacterial proteins. It contains a two pair of highly conserved cysteine residues that may be involved in metal coordination. It is predicted to fold into a structure typical for zinc beta ribbon domains. Some proteins contain multiple copies of this domain.

[]

0

[ "PFAM" ]

[ "PF26788" ]

[ "DUF8260" ]

[ 44 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 43, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8260

DUF8260

8

IPR059305

59,305

Domain of unknown function DUF8261

DUF8261

Domain

18

false

This domain is found exclusively in uncharacterised proteins from Legionellales species. It contains several highly conserved cysteine residues which are predicted to form disulfide bonds. It is composed of two repeats predicted to consist of a small three-stranded antiparallel β-sheet and an α-helix packed on it.

[]

0

[ "PFAM" ]

[ "PF26789" ]

[ "DUF8261" ]

[ 18 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Legionellales" ]

[ 18 ]

1

[]

0

true

Domain

Domain of unknown function DUF8261

DUF8261

1

IPR059306

59,306

Domain of unknown function DUF8262

DUF8262

Domain

394

false

This entry represents the N-terminal helical domain found in a family of secreted halobacterial proteins.

[]

0

[ "PFAM" ]

[ "PF26790" ]

[ "DUF8262" ]

[ 394 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 394 ]

1

[]

0

true

Domain

Domain of unknown function DUF8262

DUF8262

6

IPR059307

59,307

Domain of unknown function DUF8263

DUF8263

Domain

1,540

false

This domain is found in uncharacterised fungal proteins. It is predicted to fold into a small three stranded β-sheet and α-helices. It contains a highly conserved SD[ED]E sequence motif.

[]

0

[ "PFAM" ]

[ "PF26792" ]

[ "DUF8263" ]

[ 1540 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1540 ]

1

[]

0

true

Domain

Domain of unknown function DUF8263

DUF8263

7

IPR059308

59,308

Domain of unknown function DUF8264

DUF8264

Domain

396

false

This entry represents the C-terminal helical domain found in a family of secreted halobacterial proteins. This domain is found C-terminal to .ED A0A202E986.1/257-460;

[]

0

[ "PFAM" ]

[ "PF26793" ]

[ "DUF8264" ]

[ 396 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 396 ]

1

[]

0

true

Domain

Domain of unknown function DUF8264

DUF8264

9

IPR059309

59,309

Domain of unknown function DUF8265

DUF8265

Domain

114

false

This domain is found in uncharacterised proteins mainly from alphaproteobacteria. It is predicted to fold into an α/β structure composed of a four-stranded β-sheet and α-helix. It contains to highly conserved cysteine residues that are predicted to form disulfide bond bridging the α-helix and the β-sheet. Besides the c...

[]

0

[ "PFAM" ]

[ "PF26795" ]

[ "DUF8265" ]

[ 114 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "mine drainage metagenome" ]

[ 113, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8265

DUF8265

2

IPR059310

59,310

Domain of unknown function DUF8266

DUF8266

Domain

97

false

This domain is found in uncharacterised proteins from Halobacteria. It is predicted to fold into an α/β structure composed of a small four stranded antiparallel β-sheet and α-helices packed on one side of it. It contains two conserved sequence motifs IPLH and RxRFW which may have functional importance. This domain is f...

[]

0

[ "PFAM" ]

[ "PF26796" ]

[ "DUF8266" ]

[ 97 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 97 ]

1

[]

0

true

Domain

Domain of unknown function DUF8266

DUF8266

4

IPR059311

59,311

Domain of unknown function DUF8267

DUF8267

Domain

26

false

This domain is found in uncharacterised fungal proteins. It is predicted to adopt an α/β structure consisting of an antiparallel β-sheet and α-helices packed on one side of it.

[]

0

[ "PFAM" ]

[ "PF26797" ]

[ "DUF8267" ]

[ 26 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dikarya" ]

[ 26 ]

1

[]

0

true

Domain

Domain of unknown function DUF8267

DUF8267

7

IPR059312

59,312

Domain of unknown function DUF8268

DUF8268

Domain

586

false

This entry represents a domain from a family of uncharacterised proteins in the Archaea. The domain is predominantly found in members of the Methanobacteriota phylum, specifically within the Halobacteria class. Proteins containing this domain are typically integral membrane proteins with two transmembrane helices. The ...

[]

0

[ "PFAM" ]

[ "PF26799" ]

[ "DUF8268" ]

[ 586 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 586 ]

1

[]

0

true

Domain

Domain of unknown function DUF8268

DUF8268

6

IPR059313

59,313

Domain of unknown function DUF8269

DUF8269

Domain

22

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a β-sandwich structure consisting of two pairs of swapped β-hairpins. This domain is found in combination with TauE ( ) suggesting it may be associated with the membrane.

[]

0

[ "PFAM" ]

[ "PF26800" ]

[ "DUF8269" ]

[ 22 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermodesulfobacteriota", "hydrothermal vent metagenome" ]

[ 21, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8269

DUF8269

9

IPR059314

59,314

Domain of unknown function DUF8270

DUF8270

Domain

62

false

This domain is found in uncharacterised proteins. It contains two pairs of conserved cysteine residues which are predicted to form disulfide bonds.

[]

0

[ "PFAM" ]

[ "PF26802" ]

[ "DUF8270" ]

[ 62 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "marine sediment metagenome" ]

[ 45, 12, 5 ]

3

[]

0

true

Domain

Domain of unknown function DUF8270

DUF8270

3

IPR059316

59,316

Protein of unknown function DUF8272

DUF8272

Family

441

false

This entry represents a family of small phage proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF26839" ]

[ "DUF8272" ]

[ 441 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "Viruses" ]

[ 4, 437 ]

2

[]

0

true

Family

Protein of unknown function DUF8272

DUF8272

1

IPR059317

59,317

Domain of unknown function DUF8273

DUF8273

Domain

37

false

This domain is found in uncharacterised proteins mainly from insects. It is predicted to adopt an α/β structure composed of a curved six-stranded antiparallel β-sheet packed with α-helices.

[]

0

[ "PFAM" ]

[ "PF26842" ]

[ "DUF8273" ]

[ 37 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Neoptera" ]

[ 37 ]

1

[]

0

true

Domain

Domain of unknown function DUF8273

DUF8273

3

IPR059318

59,318

Domain of unknown function DUF8274

DUF8274

Domain

19

false

This entry represents a domain found in uncharacterised proteins exclusively from Vitrellaceae. It is predicted to adopt an unique α/β structure featuring antiparallel β-sheet and an α-helix nearly orthogonal to the former.

[]

0

[ "PFAM" ]

[ "PF26910" ]

[ "DUF8274" ]

[ 19 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Vitrella brassicaformis" ]

[ 19 ]

1

[]

0

true

Domain

Domain of unknown function DUF8274

DUF8274

7

IPR059319

59,319

Domain of unknown function DUF8275

DUF8275

Domain

872

false

This entry represents a domain of unknown function found mostly in fungal proteins. This domain contains a coiled coil hairpin domain similar to that of [ ].

[]

0

[ "PFAM" ]

[ "PF26916" ]

[ "DUF8275" ]

[ 872 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 872 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF8275

DUF8275

6

IPR059320

59,320

Domain of unknown function DUF8276

DUF8276

Domain

149

false

This domain is found in uncharacterised prokaryotic proteins. It is predicted to adopt mainly α-helical structure with unique topology. It is found in combination with and .

[]

0

[ "PFAM" ]

[ "PF26921" ]

[ "DUF8276" ]

[ 149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriaceae", "Trichonephila clavata", "mine drainage metagenome" ]

[ 139, 5, 1, 4 ]

4

[]

0

true

Domain

Domain of unknown function DUF8276

DUF8276

7

IPR059321

59,321

Domain of unknown function DUF8277

DUF8277

Domain

183

false

This entry represents a domain found in a variety of mycobacteriophage. Structure prediction suggests that these proteins form a confident homodimer. The domain is composed of a four stranded β-sheet with two helices packed on one side. The homo-oligomer interaction is mediated by the C-terminal β-strand. The function ...

[]

0

[ "PFAM" ]

[ "PF26922" ]

[ "DUF8277" ]

[ 183 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Aduncisulcus paluster", "Mycobacteriaceae", "Viruses" ]

[ 1, 22, 160 ]

3

[]

0

true

Domain

Domain of unknown function DUF8277

DUF8277

7

IPR059322

59,322

Domain of unknown function DUF8278

DUF8278

Domain

51

false

This entry represents a domain found in uncharacterised proteins form Sulfolobales. It is predicted to fold into an elaborated with additional elements β-barrel that may be remotely related to OB-fold domains.

[]

0

[ "PFAM" ]

[ "PF26923" ]

[ "DUF8278" ]

[ 51 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Sulfolobaceae" ]

[ 51 ]

1

[]

0

true

Domain

Domain of unknown function DUF8278

DUF8278

2

IPR059323

59,323

Domain of unknown function DUF8279

DUF8279

Domain

251

false

This domain is found in uncharacterised proteins mainly from Alveolata species. It has a remote similarity to various Poly(ADP-ribose) polymerases PARPs and two of the residues involved in catalysis (His and Tyr) are conserved. The Af2 predicted models of many the members are not of a good quality.

[]

0

[ "PFAM" ]

[ "PF26928" ]

[ "DUF8279" ]

[ 251 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dinophyceae" ]

[ 251 ]

1

[]

0

true

Domain

Domain of unknown function DUF8279

DUF8279

9

IPR059324

59,324

Domain of unknown function DUF8280

DUF8280

Domain

66

false

This domain was found in uncharacterised bacterial proteins. It is predicted to fold into an α/β structure composed of three stranded antiparallel β-sheet packed with two α-helices.

[]

0

[ "PFAM" ]

[ "PF26929" ]

[ "DUF8280" ]

[ 66 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina mazei", "metagenomes", "uncultured Caudovirales phage" ]

[ 62, 1, 2, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF8280

DUF8280

4

IPR059325

59,325

Domain of unknown function DUF8281

DUF8281

Domain

13

false

This domain is found in uncharacterised proteins mainly from Parachela species. It contains several highly conserved cysteine residues that are predicted to form disulfide bonds.

[]

0

[ "PFAM" ]

[ "PF26930" ]

[ "DUF8281" ]

[ 13 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Hypsibioidea" ]

[ 13 ]

1

[]

0

true

Domain

Domain of unknown function DUF8281

DUF8281

3

IPR059326

59,326

Domain of unknown function DUF8282

DUF8282

Domain

29

false

This entry represents a domain found in uncharacterised proteins mainly from Stramenopiles lineages. It contains two pair of highly conserved cysteine residues that may be involved in metal coordination.

[]

0

[ "PFAM" ]

[ "PF26931" ]

[ "DUF8282" ]

[ 29 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillariophyta" ]

[ 29 ]

1

[]

0

true

Domain

Domain of unknown function DUF8282

DUF8282

5

IPR059327

59,327

Domain of unknown function DUF8283

DUF8283

Domain

36

false

This domain is found in uncharacterised proteins mainly from Alveolata lineage. It is predicted to fold into an alpha-solenoid with a structural similarity to TAL effector repeats known to bind to double stranded DNA.

[]

0

[ "PFAM" ]

[ "PF26932" ]

[ "DUF8283" ]

[ 36 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alveolata" ]

[ 36 ]

1

[]

0

true

Domain

Domain of unknown function DUF8283

DUF8283

2

IPR059328

59,328

Domain of unknown function DUF8284

DUF8284

Domain

72

false

This domain is found in uncharacterised proteins mainly from Alveolata lineage. It is predicted to fold into a simple structure composed of beta-hairpin followed by an alpha-hairpin. Many proteins contain tandem repeats of this domain. It is frequently found in combination with and .

[]

0

[ "PFAM" ]

[ "PF26933" ]

[ "DUF8284" ]

[ 72 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 72 ]

1

[]

0

true

Domain

Domain of unknown function DUF8284

DUF8284

8

IPR059329

59,329

Domain of unknown function DUF8285

DUF8285

Domain

36

false

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an α/β structure composed of antiparallel four-stranded β-sheet packed with α-helices on one side. This domain is frequently found in combination with .

[]

0

[ "PFAM" ]

[ "PF26934" ]

[ "DUF8285" ]

[ 36 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina mazei" ]

[ 35, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF8285

DUF8285

2

IPR059330

59,330

Domain of unknown function DUF8286

DUF8286

Domain

458

false

This domain is ubiquitously found in uncharacterised proteins. It is found in combination with different domains and give the AlphaFold prediction either associates with another part of th polypeptide chain or with another molecule.

[]

0

[ "PFAM" ]

[ "PF26935" ]

[ "DUF8286" ]

[ 458 ]

1

[]

0

[ "8gkh", "9ceu", "9cev", "9cew", "9cex", "9cey", "9cez", "9cf0", "9cf1", "9cf2", "9cf3" ]

11

[]

0

[]

0

null

[ "Eukaryota", "Megaviricetes", "candidate division CPR1 bacterium ADurb.Bin160", "viral metagenome" ]

[ 347, 38, 1, 72 ]

4

[]

0

true

Domain

Domain of unknown function DUF8286

DUF8286

8

IPR059331

59,331

Domain of unknown function DUF8287

DUF8287

Domain

31

false

This domain is found in uncharacterised archaeal proteins. It contains three cysteine and a histidine residues that are highly conserved. It is predicted to fold into a structure that resembles a circularly permuted zinc-ribbon domains.

[]

0

[ "PFAM" ]

[ "PF26936" ]

[ "DUF8287" ]

[ 31 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 31 ]

1

[]

0

true

Domain

Domain of unknown function DUF8287

DUF8287

9