LiteFold/InterPro · Datasets at Hugging Face

IPR061179

61,179

WIAG-tail domain

WIAG-tail_dom

Domain

414

false

This 80-amino acid domain occurs in proteins from bacilli in a single copy at the C terminus. In most proteins, the domain immediately follows a long, variable run of tandem 10-amino acid repeats. The domain is named for its C-terminal motif, WIAxGx, hence the name WIAG-tail.

[]

0

[ "NCBIFAM" ]

[ "NF012201" ]

[ "WIAG-tail" ]

[ 414 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 414 ]

1

[]

0

true

Domain

WIAG-tail domain

WIAG-tail_dom

5

IPR061180

61,180

Spike base protein Rcc01079-like

Rcc01079-like

Family

864

false

Proteins of this family are found in tailed bacteriophages and proteobacterial prophages, including Spike base proteinRcc01079 from Rhodobacter capsulatus ( ). Some members form the base of the spike on the capsids of phage and phage-related gene transfer agents [ ].

[]

0

[ "NCBIFAM" ]

[ "NF048002" ]

[ "spike_base" ]

[ 864 ]

1

[]

0

[ "6tb9", "6tba", "6tsu", "6tui", "8cjz" ]

5

[ "PUB00153971" ]

[ "32541663" ]

[ "Structure and mechanism of DNA delivery of a gene transfer agent." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 802, 44, 18 ]

3

[]

0

true

Family

Spike base protein Rcc01079-like

Rcc01079-like

6

IPR061181

61,181

Arginine synthesis PII-interacting regulator PirA

PirA

Family

283

false

This entry represents a group of cyanobacterial proteins, including PirA from Synechocystis sp. ( ). It has been shown that the small protein PirA regulates flux into the ornithine-ammonia cycle (OAC), the key hub of cyanobacterial nitrogen stockpiling and remobilisation. PirA interacts with the central carbon/nitrogen...

[]

0

[ "NCBIFAM" ]

[ "NF050139" ]

[ "PirA_Argsyn" ]

[ 283 ]

1

[]

0

[]

0

[ "PUB00162602" ]

[ "33758091" ]

[ "The Novel PII-Interacting Protein PirA Controls Flux into the Cyanobacterial Ornithine-Ammonia Cycle." ]

[ 2021 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 283 ]

1

[]

0

true

Family

Arginine synthesis PII-interacting regulator PirA

PirA

4

IPR061182

61,182

Bacteriocin fulvocin C-related

Fulvocin-rel

Family

274

false

This protein family represents a group of uncharacterised proteins from bacteria and fungi, including putative precursors of Bacteriocin fulvocin-C ( ). Fulvocin C was described as a bacteriocin from Myxococcus fulvus, 45 amino acids long with 8 cysteines [ ]. The precursor form was not described. However, the most clo...

[]

0

[ "NCBIFAM" ]

[ "NF033852" ]

[ "fulvocin_rel" ]

[ 274 ]

1

[]

0

[]

0

[ "PUB00105374" ]

[ "6783114" ]

[ "The primary structure of fulvocin C from Myxococcus fulvus." ]

[ 1981 ]

1

[]

0

null

[ "Bacteria", "Pezizomycotina" ]

[ 236, 38 ]

2

[]

0

true

Family

Bacteriocin fulvocin C-related

Fulvocin-rel

7

IPR061183

61,183

PLxRFG domain

Tail-700

Domain

242

false

This domain, nearly 700 residues long, begins with a nearly invariant motif YxPLxRFGx[YF]. It occurs as the extreme C-terminal domain of large size proteins mainly found in tailed bacteriophages and bacterial prophages, some over 5000 amino acids long with an average of nearly 3000. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF032893" ]

[ "tail-700" ]

[ 242 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Fusarium", "Pseudomonadati", "metagenomes" ]

[ 29, 2, 195, 16 ]

4

[]

0

true

Domain

PLxRFG domain

Tail-700

3

IPR061186

61,186

P110/LppT-like adhesin, N-terminal domain

P110_N

Domain

182

false

This entry represents a domain found at the N-terminal end of the multifunctional adhesin P110 from Mycoplasma hyopneumoniae and homologues presumed also to be adhesins, including LppT (lipoprotein T), which despite its name seems to lack the signal peptide region Cys residue required for conversion into a lipoprotein,...

[]

0

[ "NCBIFAM" ]

[ "NF038058" ]

[ "adhes_P110_Nter" ]

[ 182 ]

1

[]

0

[]

0

[ "PUB00105542", "PUB00105543" ]

[ "12576592", "9695283" ]

[ "Characterization of LppS, an adhesin of Mycoplasma conjunctivae.", "Identification of a novel adhesin-like glycoprotein from Mycoplasma hyopneumoniae." ]

[ 2003, 1998 ]

2

[]

0

null

[ "Mesomycoplasma" ]

[ 182 ]

1

[]

0

true

Domain

P110/LppT-like adhesin, N-terminal domain

P110_N

5

IPR061187

61,187

SCO2400-like

Family

864

false

SCO2400 from Streptomyces coelicolor ( ), and its apparent orthologues from other Streptomyces species, have small regions of strong sequence conservation, separated by long regions of low-complexity sequence that is rather poorly conserved. These proteins include the N-terminal region of 30 amino acids that includes a...

[]

0

[ "NCBIFAM" ]

[ "NF049861" ]

[ "SCO2400_fam" ]

[ 864 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 864 ]

1

[]

0

true

Family

SCO2400-like

6

IPR061188

61,188

RDAC-containing

Family

153

false

Members of this uncharacterised protein family average about 80 amino acids in length, and do not seem to belong to any well-conserved gene neighbourhoods. The family is named for a motif rather well conserved in some members.

[]

0

[ "NCBIFAM" ]

[ "NF047998" ]

[ "RDAC_fam" ]

[ 153 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 151, 2 ]

2

[]

0

true

Family

RDAC-containing

6

IPR061189

61,189

Histone-like protein Rv3852

Rv3852

Family

154

false

Proteins of this family were initially annotated as histone-like nucleoid-structuring protein. However, a recent study has shown that protein Rv3852 is not a typical nucleoid-associated protein (NAP) and is not Involved in nucleoid compaction and virulence regulation [ ].

[]

0

[ "NCBIFAM" ]

[ "NF050153" ]

[ "Rv3852_fam" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00162825" ]

[ "28559300" ]

[ "Rv3852 (H-NS) of Mycobacterium tuberculosis Is Not Involved in Nucleoid Compaction and Virulence Regulation." ]

[ 2017 ]

1

[]

0

null

[ "Mycobacteriaceae" ]

[ 154 ]

1

[]

0

true

Family

Histone-like protein Rv3852

Rv3852

2

IPR061190

61,190

Bdr, N-terminal domain

Bdr_N

Domain

187

false

Bdr (Borrelia direct repeat) proteins have an N-terminal domain, a variable length region of repeats, typically 11 amino acids long with a KID repeat, and a non-repetitive C-terminal domain. This entry represents the conserved N-terminal domain of families other than BdrA, BdrB, and BdrC, which are described by the rel...

[]

0

[ "NCBIFAM" ]

[ "NF040500" ]

[ "Bdr_N_group2" ]

[ 187 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 187 ]

1

[]

0

true

Domain

Bdr, N-terminal domain

Bdr_N

1

IPR061192

61,192

NMCC_0638 family (lipo)protein

Lipo_NMCC_0638

Family

275

false

Members of this protein, including NMCC_0638 from Neisseria meningitidis, have two mostly invariant Cys residues. In about a quarter of family members, an additional Cys residue is present in what appears to be a lipoprotein signal peptide.

[]

0

[ "NCBIFAM" ]

[ "NF047650" ]

[ "lipo_NMCC_0638" ]

[ 275 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2, 273 ]

2

[]

0

true

Family

NMCC_0638 family (lipo)protein

Lipo_NMCC_0638

9

IPR061193

61,193

LIC10280-like

Family

210

false

This entry represents a group of uncharacterised bacterial proteins, including LIC10280 from Leptospira interrogans ( ). The lfb1 gene is widely used for Leptospira identification. A short signal peptide is found in the N-terminal of Lfb1 proteins. It has been reported that Lfb1 was associated with Leptospira interroga...

[]

0

[ "NCBIFAM" ]

[ "NF050085" ]

[ "LIC10280_fam" ]

[ 210 ]

1

[]

0

[]

0

[ "PUB00163040", "PUB00163041" ]

[ "36112204", "21176235" ]

[ "Identifying Leptospira interrogans putative virulence factors with a yeast protein expression screen.", "Rapid Leptospira identification by direct sequencing of the diagnostic PCR products in New Caledonia." ]

[ 2022, 2010 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 210 ]

1

[]

0

true

Family

LIC10280-like

4

IPR061194

61,194

Multiple cyclophane triceptide AmcA, group 1

AmcA_1

Family

136

false

Members of this family belong to one of several classes of peptide natural product synthesised on the ribosome and then post-translationally modified (RiPP), where the modification begins with the actinobacterial multiple cyclophane-forming radical SAM peptide maturase AmcB ( ) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041721" ]

[ "phane_AmcA_1" ]

[ 136 ]

1

[]

0

[]

0

[ "PUB00152924" ]

[ "36454686" ]

[ "A Prevalent Group of Actinobacterial Radical SAM/SPASM Maturases Involved in Triceptide Biosynthesis." ]

[ 2022 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 136 ]

1

[]

0

true

Family

Multiple cyclophane triceptide AmcA, group 1

AmcA_1

8

IPR061196

61,196

Type VI secretion system protein IglI-like

IglI-like

Family

133

false

IglI (intracellular growth locus I), from Francisella tularensis, occurs within the type VI secretion system (T6SS) locus, and is important to virulence [ ]. This entry represents a broad family of related proteins, the majority of which are likewise encoded in the vicinity of other T6SS proteins such as baseplate subu...

[]

0

[ "NCBIFAM" ]

[ "NF041244" ]

[ "IglI_fam" ]

[ 133 ]

1

[]

0

[]

0

[ "PUB00106258" ]

[ "21690239" ]

[ "IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS." ]

[ 2011 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 133 ]

1

[]

0

true

Family

Type VI secretion system protein IglI-like

IglI-like

2

IPR061200

61,200

IlvX

Family

125

false

The very short peptide IlvX, 16 amino acids long, is found in Escherchia coli and related species as the apparent first encoded peptide from the ilvXGEDA operon, for which ilvL, further upstream, is the classical attentuator system leader peptide controlling expression. IlvX is preceded by a ribosome binding site, term...

[]

0

[ "NCBIFAM" ]

[ "NF038286" ]

[ "peptide_16_IlvX" ]

[ 125 ]

1

[]

0

[]

0

[ "PUB00104040" ]

[ "19734316" ]

[ "Small stress response proteins in Escherichia coli: proteins missed by classical proteomic studies." ]

[ 2010 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 125 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

IlvX

9

IPR061201

61,201

Adhesin RatA-like

RatA-like

Family

698

false

This entry represents a group of uncharacterised proteins from enterobacterales, including RatA ( ). RatA, encoded in a Salmonella pathogenicity island next to its homologue RatB, is a long protein consisting almost entirely of repeats of a Bacterial Immunoglobulin-like 21/Adhesion domain pair (see and , respectively) ...

[]

0

[ "NCBIFAM" ]

[ "NF011843" ]

[ "PRK15315.1" ]

[ 698 ]

1

[]

0

[]

0

[ "PUB00016646" ]

[ "12540539" ]

[ "Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants." ]

[ 2003 ]

1

[]

0

null

[ "Salmonella" ]

[ 698 ]

1

[]

0

true

Family

Adhesin RatA-like

RatA-like

8

IPR061202

61,202

Membrane protein Msa

Msa

Family

124

false

Msa (SA1233) was first described in Staphylococcus aureus as Modulator of SarA, but later reports suggested the locus was actually a non-coding gene, msaC, in the 3'-untranslated region of cold shock protein CspA (msaB) [ , , ]. This protein family includes Msa and its homologues across a broad taxonomic range within f...

[]

0

[ "NCBIFAM" ]

[ "NF038270" ]

[ "membran_MsaC" ]

[ 124 ]

1

[]

0

[]

0

[ "PUB00105686", "PUB00105687", "PUB00105688" ]

[ "16946251", "18047728", "25155591" ]

[ "Identification and characterization of msa (SA1233), a gene involved in expression of SarA and several virulence factors in Staphylococcus aureus.", "Structure and function predictions of the Msa protein in Staphylococcus aureus.", "The msaABCR operon regulates resistance in vancomycin-intermediate Staphylococ...

[ 2006, 2007, 2014 ]

3

[]

0

null

[ "Bacillati", "human gut metagenome" ]

[ 123, 1 ]

2

[]

0

true

Family

Membrane protein Msa

Msa

9

IPR061204

61,204

Colistin stress protein ABZJ_00068-like

ABZJ_00068-like

Family

108

false

This entry represents ABZJ_00068 from Acinetobacter baumannii ( ) and similar proteins from Acinetobacter species. Members of this protein family were shown to be the second most differentially up-regulated protein during colistin challenge in one study, and in a colistin-dependent mutant strain in another study [ , ]....

[]

0

[ "NCBIFAM" ]

[ "NF051864" ]

[ "ABZJ_00068_fam" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00105620", "PUB00163065" ]

[ "28275586", "29079752" ]

[ "Colistin Resistance in Acinetobacter baumannii MDR-ZJ06 Revealed by a Multiomics Approach.", "Transition of colistin dependence into colistin resistance in Acinetobacter baumannii." ]

[ 2017, 2017 ]

2

[]

0

null

[ "Acinetobacter" ]

[ 108 ]

1

[]

0

true

Family

Colistin stress protein ABZJ_00068-like

ABZJ_00068-like

4

IPR061209

61,209

LIC_11139-like

Family

160

false

Members of this family are mainly found in Leptospira, including LIC_11139 from Leptospira interrogans. They are putative lipoproteins with only a single Cys residue, invariant at the proposed lipoprotein signal cleavage site. Residues in the -1 position are unusual for lipoproteins in general, but consistent with obse...

[]

0

[ "NCBIFAM" ]

[ "NF033171" ]

[ "lipo_LIC11139" ]

[ 160 ]

1

[]

0

[]

0

[ "PUB00105015" ]

[ "26890609" ]

[ "What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira." ]

[ 2016 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 160 ]

1

[]

0

true

Family

LIC_11139-like

1

IPR061210

61,210

Npun_F0296-like domain

Npun_F0296-like_dom

Domain

463

false

This domain is found in Npun_F0296 from the filamentous cyanobacterium Nostoc punctiforme and similar bacterial sequences. This protein has a PEP-CTERM-like C-terminal protein-sorting domain that is induced specifically during the formation of hormogonia, which are filamentous colonies with a cooperative, pilus-driven,...

[]

0

[ "NCBIFAM" ]

[ "NF050191" ]

[ "Npun_F0296_dom" ]

[ 463 ]

1

[]

0

[]

0

[ "PUB00162603" ]

[ "40358234" ]

[ "Cyanoexosortase B is essential for motility, biofilm formation, and scytonemin production in a filamentous cyanobacterium." ]

[ 2025 ]

1

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 451, 12 ]

2

[]

0

true

Domain

Npun_F0296-like domain

Npun_F0296-like_dom

3

IPR061211

61,211

Choice-of-anchor R domain

Choice_anch_R

Domain

415

false

This GC-type dockerin domain occurs, so far, primarily in metagenome-assembled genomes from the taxonomic class Phycisphaerae, within the Planctomycetota, where it seems to anchor a number of otherwise unrelated proteins. The most frequent C-terminal anchoring domain for members of this group is PEP-CTERM (see ) or a P...

[]

0

[ "NCBIFAM" ]

[ "NF041539" ]

[ "choice_anch_R" ]

[ 415 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Bacteriophage sp.", "Eukaryota", "metagenomes" ]

[ 5, 331, 1, 5, 73 ]

5

[]

0

true

Domain

Choice-of-anchor R domain

Choice_anch_R

8

IPR061212

61,212

SdrH-like, C-terminal domain

SdrH-like_C

Domain

155

false

This domain is found at the C-terminal end of SdrH from Staphylococcus epidermidis ( ) and similar staphylococcal proteins, SdrH is one of three MSCRAMM family proteins, but is atypical in lacking a recognisable LPXTG-like C-terminal recognition sequence for cell wall anchoring. This domain is C-terminal to the repetit...

[]

0

[ "NCBIFAM" ]

[ "NF039170" ]

[ "SdrH_fam_CTERM" ]

[ 155 ]

1

[]

0

[]

0

[ "PUB00081255", "PUB00105777" ]

[ "10878118", "31198057" ]

[ "The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis.", "Time-variable expression levels of mazF, atlE, sdrH, and bap genes during biofilm formation in Staphylococcus epidermidis." ]

[ 2000, 2019 ]

2

[]

0

null

[ "Staphylococcaceae", "human gut metagenome" ]

[ 154, 1 ]

2

[]

0

true

Domain

SdrH-like, C-terminal domain

SdrH-like_C

5

IPR061214

61,214

LIC_13076-like

Family

141

false

This family occurs in the genus Leptospira, including LIC_13076. Members are predicted to be surface-exposed proteins and are possible lipoproteins [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047624" ]

[ "LIC_13076_fam" ]

[ 141 ]

1

[]

0

[]

0

[ "PUB00159320" ]

[ "28352257" ]

[ "A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis." ]

[ 2017 ]

1

[]

0

null

[ "Leptospiraceae" ]

[ 141 ]

1

[]

0

true

Family

LIC_13076-like

8

IPR061215

61,215

Membrane protein MAGa3780-like

MAGa3780-like

Family

133

false

Members of this entry, such as MAGa3780 from Mycoplasmopsis agalactiae, are membrane proteins. This family appears to be a related to the Pr6Pr family membrane proteins described by model .

[]

0

[ "NCBIFAM" ]

[ "NF046009" ]

[ "MAGa3780_fam" ]

[ 133 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 133 ]

1

[]

0

true

Family

Membrane protein MAGa3780-like

MAGa3780-like

6

IPR061217

61,217

Putative cell division protein FtsL, alphaproteobacteria

FtsL_put_alphaproteobact

Family

2,418

false

Members of this family appear to include the cell division protein FtsL from alphaproteobacteria, which lies outside the scope of model [ , , ].

[]

0

[ "NCBIFAM" ]

[ "NF049847" ]

[ "FtsL_COG5462" ]

[ 2418 ]

1

[]

0

[]

0

[ "PUB00162897", "PUB00162898", "PUB00162899" ]

[ "24975755", "24155949", "24532768" ]

[ "Identification of essential alphaproteobacterial genes reveals operational variability in conserved developmental and cell cycle systems.", "Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector.", "Function and localization d...

[ 2014, 2013, 2014 ]

3

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 4, 2392, 22 ]

3

[]

0

true

Family

Putative cell division protein FtsL, alphaproteobacteria

FtsL_put_alphaproteobact

7

IPR061221

61,221

MAG0920-like

Family

59

false

Members of this family include Mbov_0101 and Mbov_0775 from Mycoplasmopsis bovis, two paralogs also from Mycoplasmopsis agalactiae and MAG0920 from M. agalactiae ( ).

[]

0

[ "NCBIFAM" ]

[ "NF045996" ]

[ "MAG0920_fam" ]

[ 59 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 59 ]

1

[]

0

true

Family

MAG0920-like

2

IPR061223

61,223

Post-COAP-1 domain

Post_COAP_1_dom

Domain

63

false

Post-COAP-1 is a C-terminal domain, about 115 amino acids in length, found in a subset of proteins with the choice-of-anchor P (COAP) domain (see ). This domain is seen primarily in non-cultured prokaryotes.

[]

0

[ "NCBIFAM" ]

[ "NF041523" ]

[ "post_COAP_1" ]

[ 63 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Fistulifera solaris", "marine sediment metagenome" ]

[ 8, 50, 1, 4 ]

4

[]

0

true

Domain

Post-COAP-1 domain

Post_COAP_1_dom

5

IPR061225

61,225

LDCC motif small metal-binding domain

CC_mini_metal

Domain

158

false

This small and previously undescribed domain, just over 30 amino acids in length, occurs primarily in small proteins of unknown function. It is identified as a probable heavy metal-binding domain by its CysCys pair (seen often in mercury resistance proteins), by the presence of metal-binding or transport domains such a...

[]

0

[ "NCBIFAM" ]

[ "NF040898" ]

[ "CC_mini_metal" ]

[ 158 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 152, 6 ]

2

[]

0

true

Domain

LDCC motif small metal-binding domain

CC_mini_metal

2

IPR061228

61,228

PA0050-like

Family

49

false

Members of this family of small proteins include PA0050 in Pseudomonas aeruginosa ( ), average about 46 amino acids in length, starting with an apparent N-terminal signal peptide and containing four invariant Cys residues, and including a CxC motif near the C terminus. While the function remains unknown, expression was...

[]

0

[ "NCBIFAM" ]

[ "NF047882" ]

[ "PA0050_fam" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00163019", "PUB00163020" ]

[ "17581126", "12644476" ]

[ "Responses of Pseudomonas aeruginosa to low oxygen indicate that growth in the cystic fibrosis lung is by aerobic respiration.", "Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis." ]

[ 2007, 2003 ]

2

[]

0

null

[ "Diploscapter pachys", "Pseudomonas" ]

[ 2, 47 ]

2

[]

0

true

Family

PA0050-like

3

IPR061230

61,230

PDxFFG domain

PDxFFG_dom

Domain

143

false

This model represents the conserved N-terminal domain of family of large proteins with signal peptides, found in Mycoplasmatota. A short conserved N-terminal domain and a large conserved C-terminal domain are separated by poorly conserved regions of variable length in members of this group. This domain is named for its...

[]

0

[ "NCBIFAM" ]

[ "NF012210" ]

[ "PDxFFG" ]

[ 143 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 143 ]

1

[]

0

true

Domain

PDxFFG domain

PDxFFG_dom

6

IPR061234

61,234

Type I-G CRISPR-associated protein

Cas3-like_IG

Family

176

false

This protein occurs in Cas (CRISPR-associated) protein regions of type I-G CRISPR/Cas systems, occasionally as an extra C-terminal domain of a long Cas3 protein.

[]

0

[ "NCBIFAM" ]

[ "NF049934" ]

[ "adjac_Cas3_IG" ]

[ 176 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "mine drainage metagenome" ]

[ 173, 3 ]

2

[]

0

true

Family

Type I-G CRISPR-associated protein

Cas3-like_IG

3

IPR061235

61,235

SCO6881-like

Family

306

false

This family is named for SCO6881 from Streptomyces coelicolor ( ), a protein of length 462, largely hydrophobic through most of its length, although the C-terminal 140 amino acid region is low-complexity sequence, rich in Gly, Pro, Ser, Thr, and Asp. One article calls it homologous to CmdD ( ), which resembles it in ov...

[]

0

[ "NCBIFAM" ]

[ "NF047967" ]

[ "SCO6881_fam" ]

[ 306 ]

1

[]

0

[]

0

[ "PUB00162978" ]

[ "19650935" ]

[ "cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptomyces coelicolor A3(2)." ]

[ 2009 ]

1

[]

0

null

[ "Streptomycetaceae" ]

[ 306 ]

1

[]

0

true

Family

SCO6881-like

5

IPR061237

61,237

After-VIT domain

After_VWA_1

Domain

130

false

The after-VIT domain is a bacterial surface protein C-terminal domain found on some proteins that have both the Vault protein Inter-alpha-Trypsin (VIT) domain and a von Willebrand factor type A domain. Some of after-VIT domain-containing proteins may have a known C-terminal sorting signal, such as LPXTG or PEP-CTERM, i...

[]

0

[ "NCBIFAM" ]

[ "NF033769" ]

[ "after_VWA_1" ]

[ 130 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 130 ]

1

[]

0

true

Domain

After-VIT domain

After_VWA_1

5

IPR061238

61,238

AAA family ATPase, Pro-rich N-terminal domain

Pro-rich_N

Domain

387

false

This entry represents an extremely rich N-terminal domain that is well-conserved for a family of AAA family ATPases seen in Streptomyces. It is an unusual, low-complexity domain.

[]

0

[ "NCBIFAM" ]

[ "NF040555" ]

[ "Pro-rich_NTERM" ]

[ 387 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Streptomyces" ]

[ 387 ]

1

[]

0

true

Domain

AAA family ATPase, Pro-rich N-terminal domain

Pro-rich_N

8

IPR061240

61,240

PTPA-CTERM protein sorting domain

PTPA-CTERM

Domain

74

false

This C-terminal sorting and processing signal, called PTPA-CTERM, is a variant of the widespread PEP-CTERM domain. It is restricted a subset of Cyanobacteria that encode cognate sorting enzyme, named cyanoexosortase C (CrtC), and frequently is encoded near its sorting enzyme.

[]

0

[ "NCBIFAM" ]

[ "NF033465" ]

[ "PTPA-CTERM" ]

[ 74 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 74 ]

1

[]

0

true

Domain

PTPA-CTERM protein sorting domain

PTPA-CTERM

6

IPR061241

61,241

Biofilm-regulating peptide BriC-like

BriC-like

Family

37

false

BriC (Biofilm-Regulating peptide Induced by Competence), as characterised in Streptococcus pneumoniae, is a cell-cell communication peptide, or peptide pheromone, that is induced by expression of ComE (a master regulator of competence). BriC contributes to biofilm formation, and to colonisation in a mouse mole.

[]

0

[ "NCBIFAM" ]

[ "NF033771" ]

[ "colonize_BriC" ]

[ 37 ]

1

[]

0

[]

0

[ "PUB00105308" ]

[ "30308062" ]

[ "Function of BriC peptide in the pneumococcal competence and virulence portfolio." ]

[ 2018 ]

1

[]

0

null

[ "Streptococcus" ]

[ 37 ]

1

[]

0

true

Family

Biofilm-regulating peptide BriC-like

BriC-like

4

IPR061242

61,242

Cpg-like

Family

38

false

Cpg1 (Cowdria polymorphic gene 1) was described in Ehrlichia (previously Cowdria) ruminantium and investigated as a possible vaccine antigen. E. ruminantium, an obligate intracellular pathogen, causes the disease heartwater. Members of this family are found in additional species of Ehrlichia, as well as in Anaplasma an...

[]

0

[ "NCBIFAM" ]

[ "NF047987" ]

[ "cpg1_fam" ]

[ 38 ]

1

[]

0

[]

0

[ "PUB00163161", "PUB00163162" ]

[ "12381580", "37042556" ]

[ "Sequencing of a 15-kb Ehrlichia ruminantium clone and evaluation of the cpg1 open reading frame for protection against heartwater.", "Th1 and Th2 epitopes of Cowdria polymorphic gene 1 of Ehrlichia ruminantium." ]

[ 2002, 2023 ]

2

[]

0

null

[ "Anaplasmataceae", "Hevea brasiliensis" ]

[ 37, 1 ]

2

[]

0

true

Family

Cpg-like

8

IPR061244

61,244

EYxxD motif small membrane protein

Small_EYxxD

Family

111

false

This family includes small proteins with an EYxxD-like motif (for which it is named) near its N terminus, a 20-residue highly hydrophobic stretch, and a short, positively charged region rich in Lys and Arg residues, for an average length in one clade of 36 residues. Strong upstream RBS motifs, ATG start codons, appropr...

[]

0

[ "NCBIFAM" ]

[ "NF045534" ]

[ "small_EYxxD" ]

[ 111 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 111 ]

1

[]

0

true

Family

EYxxD motif small membrane protein

Small_EYxxD

6

IPR061245

61,245

ICE element protein Mbov_0400-like

ICE_Mbov_0400-like

Family

139

false

Members of this family that have been identified as belonging to Integrating Conjugative Elements (ICE) include Mbov_0400 from Mycoplasmopsis bovis, MLC_3590 and MLC_3600 from Mycoplasma mycoides subsp. capri, and MAGa3690 from Mycoplasma agalactiae.

[]

0

[ "NCBIFAM" ]

[ "NF045891" ]

[ "ICE_Mbov_0400" ]

[ 139 ]

1

[]

0

[]

0

[ "PUB00159433", "PUB00159434", "PUB00159791" ]

[ "21324191", "22693604", "25527550" ]

[ "Mycoplasma mycoides, from \"mycoides Small Colony\" to \"capri\". A microevolutionary perspective.", "Comparative geno-plasticity analysis of Mycoplasma bovis HB0801 (Chinese isolate).", "Integrative conjugative elements are widespread in field isolates of Mycoplasma species pathogenic for ruminants." ]

[ 2011, 2012, 2015 ]

3

[]

0

null

[ "Mycoplasmatota" ]

[ 139 ]

1

[]

0

true

Family

ICE element protein Mbov_0400-like

ICE_Mbov_0400-like

5

IPR061246

61,246

DxFTY motif-containing membrane protein

DxFTY_mem_plasm

Family

66

false

This protein family includes a number membrane proteins of Spiroplasmas and Mycoplasmas, and is named for its best-conserved motif, D-X-F-T-[YF], including MAG3450 from Mycoplasmopsis agalactiae PG2, and its homologues (see ).

[]

0

[ "NCBIFAM" ]

[ "NF046003" ]

[ "DxFTY_mem_plasm" ]

[ 66 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mollicutes" ]

[ 66 ]

1

[]

0

true

Family

DxFTY motif-containing membrane protein

DxFTY_mem_plasm

2

IPR061247

61,247

AAWKG-containing, N-terminal domain

AAWKG-cont_N

Domain

237

false

This domain is found in a group of proteins primarily from Streptomyces. A region outside of this domain contains 9-residue repeats that resemble the 18-residue repeats found by in the C-terminal region of eukaryotic T-complex protein 10. This group of proteins is named for the family's most prominent motif, AAWKG, to ...

[]

0

[ "NCBIFAM" ]

[ "NF038047" ]

[ "not_Tcp10" ]

[ 237 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 237 ]

1

[]

0

true

Domain

AAWKG-containing, N-terminal domain

AAWKG-cont_N

2

IPR061251

61,251

Type VI secretion system tip protein TssI/VgrG, short form

T6SS_TssI_Fran

Family

31

false

Members of this family are TssI/VgrG proteins of type VI secretion systems of a variant short form found in Francisella tularensis and related species.

[]

0

[ "NCBIFAM" ]

[ "NF041249" ]

[ "T6SS_TssI_Fran" ]

[ 31 ]

1

[]

0

[ "6u9e", "6u9f", "6u9g" ]

3

[]

0

[]

0

null

[ "Gammaproteobacteria" ]

[ 31 ]

1

[]

0

true

Family

Type VI secretion system tip protein TssI/VgrG, short form

T6SS_TssI_Fran

3

IPR061253

61,253

Garvicin Q family class II bacteriocin, core domain

GarQ_core

Domain

95

false

This entry represents the core (mature) peptide region of GarQ, the class II bacteriocin garvicin (garvieacin) Q, and homologous peptides with similar core regions. Some members, such as GarQ itself, have a classical GlyGly-containing ComC/BlpC-like leader peptide, but others have N-terminal regions (probable leader pe...

[]

0

[ "NCBIFAM" ]

[ "NF033837" ]

[ "GarQ_core" ]

[ 95 ]

1

[]

0

[ "9oil", "9wju", "9wjw" ]

3

[ "PUB00105364", "PUB00105365", "PUB00105366" ]

[ "22210221", "28827688", "30361679" ]

[ "Garvieacin Q, a novel class II bacteriocin from Lactococcus garvieae BCC 43578.", "The Non-Lantibiotic Bacteriocin Garvicin Q Targets Man-PTS in a Broad Spectrum of Sensitive Bacterial Genera.", "The extracellular loop of Man-PTS subunit IID is responsible for the sensitivity of Lactococcus garvieae to garvici...

[ 2012, 2017, 2018 ]

3

[]

0

null

[ "Bacillati" ]

[ 95 ]

1

[]

0

true

Domain

Garvicin Q family class II bacteriocin, core domain

GarQ_core

7

IPR061254

61,254

Putative surface protein MAG1430-like, central domain

MAG1430-like_central

Domain

58

false

This entry represents a well-conserved central region of putative proteins from the Mycoplasmatota. Member proteins have apparent N-terminal signal-anchor sequences but are not lipoproteins. The family is highly divergent, but the motif S[FY]ANDxxGxL[FY]L is extremely well conserved. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF045954" ]

[ "MAG1430_dom" ]

[ 58 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 58 ]

1

[]

0

true

Domain

Putative surface protein MAG1430-like, central domain

MAG1430-like_central

4

IPR061255

61,255

Sigma factor SigX-regulated lipoprotein

SrpBC

Family

113

false

It has been reported that the expression of three genes, including srpA (LIMLP_06130), srpB (LIMLP_15890), and srpC, (LIMLP_03790), was regulated by the sigma factor SigX (LIMLP_03680) and anti-sigma factor Rsx (LIMLP_03685) in pathogenic species of Leptospira. This entry represents a group of proteins from Leptospira ...

[]

0

[ "NCBIFAM" ]

[ "NF047530" ]

[ "SrpBC" ]

[ 113 ]

1

[]

0

[]

0

[ "PUB00159362" ]

[ "33301041" ]

[ "4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans." ]

[ 2020 ]

1

[]

0

null

[ "Leptospira" ]

[ 113 ]

1

[]

0

true

Family

Sigma factor SigX-regulated lipoprotein

SrpBC

4

IPR061263

61,263

TomO, hydrophobic C-terminal domain

C_TomO

Domain

77

false

This domain is found in Wolbachia-like bacteria and some lower eukaryotes. It occurs near the C terminus of distantly related paralogues such as WD_1278 and WD_0630. WD_1278 has been named TomO (toxic manipulator of oogenesis) for its effects on cultured Drosophila cells.

[]

0

[ "NCBIFAM" ]

[ "NF047986" ]

[ "C_WD1278_WD0630" ]

[ 77 ]

1

[]

0

[]

0

[ "PUB00162895", "PUB00162896" ]

[ "27498563", "29076641" ]

[ "Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants.", "Mi Casa es Su Casa: how an intracellular symbiont manipulates host biology." ]

[ 2016, 2017 ]

2

[]

0

null

[ "Arthropoda", "Bacteria" ]

[ 32, 45 ]

2

[]

0

true

Domain

TomO, hydrophobic C-terminal domain

C_TomO

6

IPR061264

61,264

Loki-CTERM protein-sorting domain

Loki-CTERM

Domain

93

false

This C-terminal protein-sorting signal is mainly found in the Asgard archaea, including the Lokiarchaeota, but resembles the PGF-CTERM sorting signal found on the S-layer-forming major cell surface glycoprotein of halophilic archaea. The most likely sorting enzyme is archaeosortase H (ArtH, ), which is most closely rel...

[]

0

[ "NCBIFAM" ]

[ "NF033507" ]

[ "Loki-CTERM" ]

[ 93 ]

1

[]

0

[]

0

[ "PUB00060405" ]

[ "22037399" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2012 ]

1

[]

0

null

[ "Bacillati", "Promethearchaeaceae", "marine sediment metagenome" ]

[ 3, 10, 80 ]

3

[]

0

true

Domain

Loki-CTERM protein-sorting domain

Loki-CTERM

2

IPR061266

61,266

VenA family class IV lanthipeptide

Lanti_IV_VenA

Family

87

false

Members of this family include VenA, precursor of the class IV lanthipeptide venezuelin, and all detectable homologues.

[]

0

[ "NCBIFAM" ]

[ "NF038147" ]

[ "lanti_IV_venA" ]

[ 87 ]

1

[]

0

[]

0

[ "PUB00105577" ]

[ "20351769" ]

[ "Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights." ]

[ 2010 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 87 ]

1

[]

0

true

Family

VenA family class IV lanthipeptide

Lanti_IV_VenA

4

IPR061267

61,267

MG406-like

Family

66

false

This protein family includes homologues to MG406 from Mycoplasma genitalium and MPN605 from Mycoplasma pneumoniae, which are about 150 amino acids long on average, highly hydrophobic, widespread in but restricted to the Mollicutes, and highly divergent there. MG406 itself appears to be essential. ATP synthase protein I...

[]

0

[ "NCBIFAM" ]

[ "NF033688" ]

[ "MG406_fam" ]

[ 66 ]

1

[]

0

[]

0

[ "PUB00105244" ]

[ "16407165" ]

[ "Essential genes of a minimal bacterium." ]

[ 2006 ]

1

[]

0

null

[ "Bacillati" ]

[ 66 ]

1

[]

0

true

Family

MG406-like

2

IPR061269

61,269

Selenite/tellurite reduction operon protein ExtJ-like

ExtJ-like

Family

62

false

ExtJ ( ), encoded within a selenite/tellurite reduction operon, has an N-terminal signal peptide, and an unusual Gly-Cys dipeptide at the C-terminal end. The length is variable, with the longer form averaging about 105 amino acids, and the shorter form averaging about 75.

[]

0

[ "NCBIFAM" ]

[ "NF040942" ]

[ "hypo_ExtJ" ]

[ 62 ]

1

[]

0

[]

0

[ "PUB00106046" ]

[ "29534491" ]

[ "Characterization of a Novel Porin-Like Protein, ExtI, from Geobacter sulfurreducens and Its Implication in the Reduction of Selenite and Tellurite." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 60, 2 ]

2

[]

0

true

Family

Selenite/tellurite reduction operon protein ExtJ-like

ExtJ-like

9

IPR061271

61,271

Metal transporter CNNM-like, C-terminal CNBH domain

CNBH_CNNM2_C

Domain

5,747

false

This CNBH domain (cyclic nucleotide-binding homology domain) is found towards the C-terminal of human Metal transporter CNNM2 and similar proteins predominantly found in animals. CNNM2 is a divalent metal cation transporter. This domain does not bind cyclic nucleotides; instead, it mediates a flat-shaped dimerisation i...

[]

0

[ "PFAM" ]

[ "PF25562" ]

[ "CNBH_CNNM2_C" ]

[ 5747 ]

1

[]

0

[ "6dfd", "6dj3", "6g52", "6mn6", "6n7e" ]

5

[ "PUB00098025", "PUB00111936", "PUB00160601" ]

[ "31864811", "30341174", "31842432" ]

[ "Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter.", "The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity.", "Structural Insights into the Intracellular Region of the Human Magnesium Tr...

[ 2020, 2018, 2019 ]

3

[]

0

null

[ "Eukaryota", "Spirosoma aureum" ]

[ 5746, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 18, 1, 10, 9, 14 ]

6

true

Domain

Metal transporter CNNM-like, C-terminal CNBH domain

CNBH_CNNM2_C

2

IPR061272

61,272

Inhibitor of vertebrate lysozyme (Ivy)-like domain

Ivy

Domain

2,314

false

C-type lysozyme enzymes, such as hen egg white lysozyme (HEWL), provide anti-bacterial activity by cleaving peptidoglycan in Gram-positive bacterial cell walls. In humans, C-type lysozyme is found in all secretions, including tears and saliva. Certain Gram-positive bacteria can produce proteins with anti-lysozyme activ...

[]

0

[ "PFAM" ]

[ "PF08816" ]

[ "Ivy" ]

[ 2314 ]

1

[]

0

[ "1gpq", "1uuz", "1xs0", "4ps6" ]

4

[ "PUB00027883", "PUB00027919", "PUB00042565" ]

[ "11278658", "15141308", "17405861" ]

[ "Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme.", "Periplasmic lysozyme inhibitor contributes to lysozyme resistance in Escherichia coli.", "Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria." ]

[ 2001, 2004, 2007 ]

3

[]

0

null

[ "Bacteria", "Halorubrum tibetense", "Opisthokonta", "ecological metagenomes" ]

[ 2305, 1, 4, 4 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Inhibitor of vertebrate lysozyme (Ivy)-like domain

Ivy

3

IPR061274

61,274

Afadin, Ras-associating domain 2

RA2_Afadin

Domain

3,244

false

Afadin, also termed ALL1-fused gene from chromosome 6 protein (AF-6), is involved in many fundamental signalling cascades in cells. In addition, it is involved in oncogenesis and metastasis. AFDN belongs to the adhesion system, probably together with the E-cadherin-catenin system, that plays a role in the organisation ...

[]

0

[ "CDD" ]

[ "cd01781" ]

[ "RA2_Afadin" ]

[ 3244 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418990", "R-MMU-418990", "R-RNO-418990" ]

[ "REACTOME:R-HSA-418990", "REACTOME:R-MMU-418990", "REACTOME:R-RNO-418990" ]

3

[ "1wxa" ]

1

[ "PUB00018559", "PUB00031294", "PUB00040466", "PUB00069444", "PUB00108730" ]

[ "12456712", "15684424", "16671149", "23481206", "20395419" ]

[ "Nectin and afadin: novel organizers of intercellular junctions.", "Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.", "Discovery of low-molecular-weight ligands for the AF6 PDZ domain.", "Afadin/AF-6 and canoe: roles in cell adhesion and beyond.", ...

[ 2003, 2005, 2006, 2013, 2010 ]

5

[ "IPR000159" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 3244 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 48, 8, 8, 4, 8 ]

5

true

Domain

Afadin, Ras-associating domain 2

RA2_Afadin

4

IPR061275

61,275

Afadin, Ras-associating domain 1

RA1_Afadin

Domain

3,165

false

This entry represents the first RA domain of afadin, which mediates its self-association [ , , , , ]. Afadin, also termed ALL1-fused gene from chromosome 6 protein (AF-6), is involved in many fundamental signalling cascades in cells. In addition, it is involved in oncogenesis and metastasis. AFDN belongs to the adhesio...

[]

0

[ "CDD" ]

[ "cd01782" ]

[ "RA1_Afadin" ]

[ 3165 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418990", "R-MMU-418990", "R-RNO-418990" ]

[ "REACTOME:R-HSA-418990", "REACTOME:R-MMU-418990", "REACTOME:R-RNO-418990" ]

3

[]

0

[ "PUB00018559", "PUB00031294", "PUB00040466", "PUB00069444", "PUB00108730", "PUB00108731" ]

[ "12456712", "15684424", "16671149", "23481206", "20395419", "11024295" ]

[ "Nectin and afadin: novel organizers of intercellular junctions.", "Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.", "Discovery of low-molecular-weight ligands for the AF6 PDZ domain.", "Afadin/AF-6 and canoe: roles in cell adhesion and beyond.", ...

[ 2003, 2005, 2006, 2013, 2010, 2000 ]

6

[ "IPR000159" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 3165 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 48, 8, 8, 7, 5 ]

6

true

Domain

Afadin, Ras-associating domain 1

RA1_Afadin

9

IPR061276

61,276

Afadin, PDZ domain

PDZ_AFDN

Domain

3,450

false

This entry represents the PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of afadin (AFDN, also known as ALL1-fused gene from chromosome 6 protein (AF6) and MLLT4), and related animal proteins. The AFDN PDZ domain interaction partners include poliovirus re...

[]

0

[ "CDD" ]

[ "cd06789" ]

[ "PDZ_AFDN-like" ]

[ 3450 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418990", "R-MMU-418990", "R-RNO-418990" ]

[ "REACTOME:R-HSA-418990", "REACTOME:R-MMU-418990", "REACTOME:R-RNO-418990" ]

3

[ "1t2m", "1xz9", "2ain", "2exg", "3axa", "7mfw", "7qcr" ]

7

[ "PUB00018559", "PUB00031294", "PUB00040466", "PUB00069444", "PUB00078424", "PUB00108730", "PUB00156108", "PUB00156650", "PUB00156652", "PUB00156653" ]

[ "12456712", "15684424", "16671149", "23481206", "25534554", "20395419", "30712672", "30473688", "18173749", "18052198" ]

[ "Nectin and afadin: novel organizers of intercellular junctions.", "Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.", "Discovery of low-molecular-weight ligands for the AF6 PDZ domain.", "Afadin/AF-6 and canoe: roles in cell adhesion and beyond.", ...

[ 2003, 2005, 2006, 2013, 2015, 2010, 2019, 2018, 2008, 2007 ]

10

[ "IPR001478" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 3450 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 50, 9, 9, 4, 8 ]

6

true

Domain

Afadin, PDZ domain

PDZ_AFDN

7

IPR061277

61,277

Rha78A-like, N-terminal immunoglobulin domain

Ig_Rha78A_N

Domain

11,957

false

This domain is found at the N-terminal of Alpha-L-rhamnosidase from Streptomyces avermitilis (Rha78A) and similar proteins. This domain adopts an immunoglobulin-like (Ig-like) fold. This domain is also found in the middle region of Bifunctional sulfatase/alpha-L-rhamnosidase. Rha78A is able to degrade p-nitrophenyl-alp...

[]

0

[ "PFAM" ]

[ "PF25788" ]

[ "Ig_Rha78A_N" ]

[ 11957 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.40", "PWY-7134" ]

[ "EC:3.2.1.40", "METACYC:PWY-7134" ]

2

[ "3w5m", "3w5n", "6dg5", "6gsz", "6i60" ]

5

[ "PUB00011520", "PUB00021302", "PUB00023642", "PUB00024541", "PUB00039525", "PUB00040414", "PUB00065054", "PUB00160632" ]

[ "10632887", "10736232", "10210178", "10753826", "16293754", "16477002", "23291751", "30387766" ]

[ "The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase.", "The solution structure of the cytokine-binding domain of the common beta-chain of the receptors f...

[ 2000, 2000, 1999, 2000, 2005, 2006, 2013, 2018 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 92, 9289, 31, 2421, 124 ]

5

[ "Homo sapiens", "Mus musculus" ]

[ 2, 1 ]

2

true

Domain

Rha78A-like, N-terminal immunoglobulin domain

Ig_Rha78A_N

1

IPR061279

61,279

Afadin, forkhead associated domain

FHA_AFDN

Domain

3,242

false

This is the FHA domain of afardin. FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine [ , , , , ]. Afadin, also termed ALL1-fused gene from chromosome 6 protein (AF-6), is involved in many fundamental signalling cascades...

[]

0

[ "CDD" ]

[ "cd22711" ]

[ "FHA_AFDN" ]

[ 3242 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418990", "R-MMU-418990", "R-RNO-418990" ]

[ "REACTOME:R-HSA-418990", "REACTOME:R-MMU-418990", "REACTOME:R-RNO-418990" ]

3

[ "1wln" ]

1

[ "PUB00018559", "PUB00031294", "PUB00040466", "PUB00069444", "PUB00108730", "PUB00108732", "PUB00108733" ]

[ "12456712", "15684424", "16671149", "23481206", "20395419", "9679199", "8242616" ]

[ "Nectin and afadin: novel organizers of intercellular junctions.", "Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.", "Discovery of low-molecular-weight ligands for the AF6 PDZ domain.", "Afadin/AF-6 and canoe: roles in cell adhesion and beyond.", ...

[ 2003, 2005, 2006, 2013, 2010, 1998, 1993 ]

7

[ "IPR000253" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 3242 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 48, 10, 4, 8 ]

4

true

Domain

Afadin, forkhead associated domain

FHA_AFDN

6

IPR061281

61,281

Protein of unknown function DUF272

DUF272

Family

135

false

This protein family represents a group of proteins from Caenorhabditis species that have no known function.

[]

0

[ "PANTHER" ]

[ "PTHR21516" ]

[ "" ]

[ 135 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditomorpha" ]

[ 135 ]

1

[ "Caenorhabditis elegans" ]

[ 37 ]

1

true

Family

Protein of unknown function DUF272

DUF272

1

IPR061283

61,283

Ephrin, cysteine rich domain

EPH_CRD

Domain

20,982

false

This entry represents the cysteine-rich domain found in ephrin proteins. Ephrins are important cell surface proteins that act as ligands for Eph receptor tyrosine kinases There are 10 EphA receptors and six EphB receptors, distinguished on sequence difference and binding preferences. They interact with the six glycosyl...

[]

0

[ "PFAM" ]

[ "PF25599" ]

[ "Ephrin_CRD" ]

[ 20982 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.1", "R-DRE-2682334", "R-DRE-3928662", "R-DRE-3928663", "R-DRE-3928664", "R-DRE-3928665", "R-GGA-2682334", "R-GGA-3928663", "R-GGA-3928665", "R-HSA-2682334", "R-HSA-2892247", "R-HSA-373760", "R-HSA-3928662", "R-HSA-3928663", "R-HSA-3928664", "R-HSA-3928665", "R-HSA-9013149", ...

[ "EC:2.7.10.1", "REACTOME:R-DRE-2682334", "REACTOME:R-DRE-3928662", "REACTOME:R-DRE-3928663", "REACTOME:R-DRE-3928664", "REACTOME:R-DRE-3928665", "REACTOME:R-GGA-2682334", "REACTOME:R-GGA-3928663", "REACTOME:R-GGA-3928665", "REACTOME:R-HSA-2682334", "REACTOME:R-HSA-2892247", "REACTOME:R-HSA-373...

45

[ "2x10", "2x11", "3fl7", "3mbw", "3mx0", "4bk4", "4bk5", "4bka", "4bkf", "4m4p", "4m4r", "7k7j", "7s7k", "8trs", "8trt", "8trv", "8tv1", "8tv5" ]

18

[ "PUB00004289", "PUB00010665", "PUB00052266", "PUB00059869", "PUB00065391", "PUB00073291", "PUB00160614", "PUB00160615", "PUB00160616" ]

[ "9853759", "11780069", "19525919", "20228801", "20505120", "23021982", "23812375", "23959867", "33770085" ]

[ "Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.", "Crystal structure of an Eph receptor-ephrin complex.", "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.", "An extracellular steric seedi...

[ 1998, 2001, 2009, 2010, 2010, 2012, 2013, 2013, 2021 ]

9

[]

0

null

[ "Eukaryota" ]

[ 20982 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 91, 11, 53, 47, 57 ]

5

true

Domain

Ephrin, cysteine rich domain

EPH_CRD

1

IPR061284

61,284

DDX60, middle domain

TPR_DDX60

Domain

893

false

This entry represents a middle domain in DDX60 and similar proteins. This domain contains a helical fold. DDX60 binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. DDX60 is non-essential in mammals [ ] but it is required for the cell fitness in kinetoplastids and trypanosomatids and plays a speci...

[]

0

[ "PFAM" ]

[ "PF26167" ]

[ "TPR_DDX60" ]

[ 893 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[]

0

[ "PUB00056836", "PUB00140287", "PUB00154169" ]

[ "21478870", "21791617", "33357443" ]

[ "A diverse range of gene products are effectors of the type I interferon antiviral response.", "DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.", "Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian H...

[ 2011, 2011, 2020 ]

3

[]

0

null

[ "Eukaryota" ]

[ 893 ]

1

[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 7, 2, 7, 1 ]

5

true

Domain

DDX60, middle domain

TPR_DDX60

8

IPR061285

61,285

Rho GTPase-activating protein 18-like, RhoGAP domain

RhoGAP_ARHGAP18-like

Domain

2,729

false

This entry represents the RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Rho GTPase-activating protein 18/28 (ARHGAP18/28) and similar animal proteins. ARHGAP18 suppresses F-actin polymerisation by inhibiting Rho [ ]. It plays a key role in tissue tension and 3D tissue shape by regulating ...

[]

0

[ "CDD" ]

[ "cd04391" ]

[ "RhoGAP_ARHGAP18" ]

[ 2729 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-8980692", "R-DME-9013148", "R-HSA-8980692", "R-HSA-9013106", "R-MMU-8980692", "R-MMU-9013106" ]

[ "REACTOME:R-DME-8980692", "REACTOME:R-DME-9013148", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-MMU-8980692", "REACTOME:R-MMU-9013106" ]

6

[]

0

[ "PUB00160465", "PUB00160466" ]

[ "21865595", "25778702" ]

[ "ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.", "YAP is essential for tissue tension to ensure vertebrate 3D body shape." ]

[ 2011, 2015 ]

2

[ "IPR000198" ]

[]

1

0

1

[ "Bilateria" ]

[ 2729 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 6, 5, 7 ]

5

true

Domain

Rho GTPase-activating protein 18-like, RhoGAP domain

RhoGAP_ARHGAP18-like

3

IPR061286

61,286

SepQ/SsaQ

Family

668

false

This entry represents Secretion system apparatus protein SsaQ from Salmonella typhimurium and similar proteins from enterobacterales. SsaQ is part of a type III secretion system [ ].

[]

0

[ "NCBIFAM" ]

[ "NF005956" ]

[ "PRK08035.1" ]

[ 668 ]

1

[]

0

[]

0

[ "PUB00097916" ]

[ "24722491" ]

[ "Functional characterization of the type III secretion ATPase SsaN encoded by Salmonella pathogenicity island 2." ]

[ 2014 ]

1

[ "IPR013385" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 668 ]

1

[]

0

true

Family

SepQ/SsaQ

7

IPR061287

61,287

Synaptosomal-associated protein 47, N-terminal SNARE domain

SNARE_SNAP47N

Domain

950

false

This entry represents the N-terminal SNARE domain of SNAP47 (Synaptosomal-associated protein 47), a member of the Qb/Qc subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. SNAP47 is a SNARE protein that may play a role in intracellular membrane fusion and is involved in ...

[]

0

[ "CDD" ]

[ "cd15888" ]

[ "SNARE_SNAP47N" ]

[ 950 ]

1

[]

0

[]

0

[ "PUB00018360", "PUB00020397", "PUB00032793", "PUB00113733", "PUB00113734", "PUB00134575", "PUB00134576" ]

[ "9861047", "11737951", "9731768", "11252968", "11066058", "16621800", "25247712" ]

[ "Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.", "The syntaxins.", "The synaptic SNARE complex is a parallel four-stranded helical bundle.", "SNARE-mediated membrane fusion.", "Fusion of membranes during the acrosome reaction: a tale of two SNA...

[ 1998, 2001, 1998, 2001, 2000, 2006, 2014 ]

7

[ "IPR000727" ]

[]

1

0

1

[ "Deuterostomia" ]

[ 950 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 10, 4, 2 ]

4

true

Domain

Synaptosomal-associated protein 47, N-terminal SNARE domain

SNARE_SNAP47N

3

IPR061288

61,288

Synaptosomal-associated protein 47, C-terminal SNARE domain

SNARE_SNAP47C

Domain

236

false

This entry represents the C-terminal SNARE domain of SNAP47 (Synaptosomal-associated protein 47), a member of the Qb/Qc subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. SNAP47 is a SNARE protein that may play a role in intracellular membrane fusion and is involved in ...

[]

0

[ "CDD" ]

[ "cd15854" ]

[ "SNARE_SNAP47C" ]

[ 236 ]

1

[]

0

[]

0

[ "PUB00018360", "PUB00020397", "PUB00032793", "PUB00113725", "PUB00113733", "PUB00113734", "PUB00113735", "PUB00134575", "PUB00134576" ]

[ "9861047", "11737951", "9731768", "9635186", "11252968", "11066058", "11718851", "16621800", "25247712" ]

[ "Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.", "The syntaxins.", "The synaptic SNARE complex is a parallel four-stranded helical bundle.", "Membrane fusion: all done with SNAREpins?", "SNARE-mediated membrane fusion.", "Fusion of membranes ...

[ 1998, 2001, 1998, 1998, 2001, 2000, 2001, 2006, 2014 ]

9

[ "IPR000727" ]

[]

1

0

1

[ "Deuterostomia" ]

[ 236 ]

1

[ "Danio rerio", "Homo sapiens", "Rattus norvegicus" ]

[ 2, 3, 1 ]

3

true

Domain

Synaptosomal-associated protein 47, C-terminal SNARE domain

SNARE_SNAP47C

3

IPR061289

61,289

Minor curlin subunit

CsgB

Family

648

false

This protein family includes Minor curlin subunit from Escherichia coli (CsgB) and similar proteins from enterobacteriales. CsgB is the structural subunit of the curli fimbriae and functions as a nucleator in the assembly of curlin monomers. Curli, which can bind to fibronectin, are coiled surface structures that assem...

[]

0

[ "NCBIFAM" ]

[ "NF007506" ]

[ "PRK10101.1" ]

[ 648 ]

1

[]

0

[]

0

[ "PUB00086869", "PUB00104551", "PUB00163224" ]

[ "24097954", "31932609", "22493266" ]

[ "Cellulose as an architectural element in spatially structured Escherichia coli biofilms.", "Assembly and substrate recognition of curli biogenesis system.", "The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism." ]

[ 2013, 2020, 2012 ]

3

[]

0

null

[ "Gammaproteobacteria", "Tylenchina" ]

[ 646, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Minor curlin subunit

CsgB

5

IPR061290

61,290

Carotenoid hydratase CrtC

CrtC

Family

749

false

This entry represents the acyclic carotenoid 1,2-hydratase (CrtC) from photosynthetic bacteria including Rhodobacter and Cereibacter species. CrtC functions as a lycopene hydratase ( ) in the biosynthesis of carotenoids spheroidene and spirilloxanthin. It catalyses the hydration of neurosporene to hydroxyneurosporene a...

[]

0

[ "PFAM", "CDD" ]

[ "PF27123", "cd21471" ]

[ "CrtC_C", "CrtC-like" ]

[ 747, 745 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.1.131", "PWY-6279", "PWY-6286", "PWY-6581", "PWY-7591", "PWY-7940", "PWY-7947" ]

[ "EC:4.2.1.131", "METACYC:PWY-6279", "METACYC:PWY-6286", "METACYC:PWY-6581", "METACYC:PWY-7591", "METACYC:PWY-7940", "METACYC:PWY-7947" ]

7

[]

0

[ "PUB00013014", "PUB00141387", "PUB00145344", "PUB00145345", "PUB00145346", "PUB00145347", "PUB00145348", "PUB00145349", "PUB00145350", "PUB00145351", "PUB00145352" ]

[ "12745254", "12788703", "26481619", "21590288", "1612412", "19136077", "11114184", "7721699", "21921032", "2747617", "14734565" ]

[ "Heterologous expression, purification, and enzymatic characterization of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus.", "Genes involved in the biosynthesis of photosynthetic pigments in the purple sulfur photosynthetic bacterium Thiocapsa roseopersicina.", "Identification of catalytically ...

[ 2003, 2003, 2016, 2011, 1992, 2009, 2000, 1995, 2011, 1989, 2004 ]

11

[]

0

null

[ "Bacteria", "Chiloscyllium punctatum", "freshwater sediment metagenome" ]

[ 747, 1, 1 ]

3

[]

0

true

Family

Carotenoid hydratase CrtC

CrtC

6

IPR061293

61,293

Type IV secretion system protein VirB5

VirB5

Family

659

false

This entry contains VirB5, a protein that is involved in the type IV DNA secretion systems typified by the Agrobacterium Ti plasmid vir system where it interacts with several other proteins essential for proper pilus formation [ ]. VirB5 is homologous to the IncN (N-type) conjugation system protein TraC [ ] as well as ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02791" ]

[ "VirB5" ]

[ 659 ]

1

[]

0

[ "7o3v", "8rt9", "8rtd" ]

3

[ "PUB00020399", "PUB00034402", "PUB00034409" ]

[ "14673074", "12855161", "15901731" ]

[ "Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101.", "F factor conjugation is a true type IV secretion system.", "Identification of the VirB4-VirB8-VirB5-VirB2 pilus assembly sequence of type IV secretion systems." ]

[ 2003, 2003, 2005 ]

3

[ "IPR014158" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 652, 2, 5 ]

3

[]

0

true

Family

Type IV secretion system protein VirB5

VirB5

2

IPR061299

61,299

Transcriptional regulator HrcA

HrcA_epsilonbact

Family

264

false

This entry is restricted to HrcA proteins from epsilonbacteria. HrcA proteins are heat-inducible transcription repressors that negatively regulate class I heat shock genes including grpE-dnaK- dnaJ and groELS operons [ ].

[]

0

[ "NCBIFAM" ]

[ "NF003033" ]

[ "PRK03911.1" ]

[ 264 ]

1

[]

0

[]

0

[ "PUB00162492" ]

[ "31765672" ]

[ "Mechanism of HrcA function in heat shock regulation in Mycobacterium tuberculosis." ]

[ 2020 ]

1

[ "IPR002571" ]

[]

1

0

1

[ "Campylobacterales" ]

[ 264 ]

1

[]

0

true

Family

Transcriptional regulator HrcA

HrcA_epsilonbact

9

IPR061300

61,300

AzlC-like, N-terminal domain

AzlC-like_N

Domain

22,000

false

This entry represents a domain found at the N-terminal of some uncharacterised bacterial proteins and the branched-chain amino acid transport protein AzlC encoded by azlC gene, which is part of the azl operon, involved in branched-chain amino acid transport [ ]. AzlCD is a bipartite histidine exporter consisting of Azl...

[]

0

[ "PFAM" ]

[ "PF03591" ]

[ "AzlC" ]

[ 22000 ]

1

[]

0

[]

0

[ "PUB00011254", "PUB00152867" ]

[ "9287000", "36377869" ]

[ "An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport.", "How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in Bacillus subtilis." ]

[ 1997, 2022 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 436, 21288, 13, 263 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

AzlC-like, N-terminal domain

AzlC-like_N

3

IPR061301

61,301

Oxamate carbamoyltransferase subunit AllF

AllF

Family

2,341

false

This protein family includes Oxamate carbamoyltransferase subunit AllF from Escherichia coli and similar bacterial proteins. AllF is a component of a carbamoyltransferase involved in the anaerobic nitrogen utilisation via the assimilation of allantoin that catalyses the conversion of oxalurate (N-carbamoyl-2-oxoglycine...

[]

0

[ "NCBIFAM" ]

[ "NF004760" ]

[ "PRK06091.1" ]

[ 2341 ]

1

[]

0

[ "3dmy" ]

1

[ "PUB00155434", "PUB00162022" ]

[ "38888336", "34494882" ]

[ "Oxamic transcarbamylase of Escherichia coli is encoded by the three genes allFGH (formerly fdrA, ylbE, and ylbF).", "An Escherichia coli FdrA Variant Derived from Syntrophic Coculture with a Methanogen Increases Succinate Production Due to Changes in Allantoin Degradation." ]

[ 2024, 2021 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4, 2320, 2, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Oxamate carbamoyltransferase subunit AllF

AllF

2

IPR061302

61,302

SPI-1 type III secretion system effector SipA

SipA

Family

703

false

Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of...

[]

0

[ "NCBIFAM" ]

[ "NF011903" ]

[ "PRK15376.1" ]

[ 703 ]

1

[]

0

[ "8vfm" ]

1

[ "PUB00054077", "PUB00163366" ]

[ "11331579", "25486861" ]

[ "Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin.", "PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation." ]

[ 2001, 2015 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 703 ]

1

[]

0

true

Family

SPI-1 type III secretion system effector SipA

SipA

3

IPR061303

61,303

Channel accessory protein ArfC, N-terminal domain

Rv0901_ArfC_N

Domain

154

false

The three-gene arf (Ammonia Release Facilitator) operon in Mycobacterium tuberculosis encodes proteins called ArfA (or OmpATb), ArfB, and ArfC. Most versions of ArfC, including Rv0901 from M. tuberculosis, contain a spacer region and then a C-terminal 'sunset' domain, but some ArfC lack the spacer region and sunset dom...

[]

0

[ "NCBIFAM" ]

[ "NF051455" ]

[ "Rv0901_ArfC_N" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00101374", "PUB00161803", "PUB00161804" ]

[ "22206986", "19168955", "21410778" ]

[ "Molecular structure and peptidoglycan recognition of Mycobacterium tuberculosis ArfA (Rv0899).", "Rv0901 from Mycobacterium tuberculosis, a possible novel virulent gene proved through the recombinant Mycobacterium smegmatis.", "Expression of the ompATb operon accelerates ammonia secretion and adaptation of Myc...

[ 2012, 2009, 2011 ]

3

[]

0

null

[ "Actinomycetes" ]

[ 154 ]

1

[]

0

true

Domain

Channel accessory protein ArfC, N-terminal domain

Rv0901_ArfC_N

5

IPR061304

61,304

M protein serotype 5/6, C-terminal domain

M_group_A_cterm

Domain

65

false

M protein (emm) is an important virulence protein and serology-defining surface antigen of Streptococcus pyogenes (group A Streptococcus). M protein has an amino-terminal YSIRK-type signal sequence (associated with cross-wall targeting in dividing cells), and a C-terminal LPXTG domain for processing by sortase and cova...

[]

0

[ "NCBIFAM" ]

[ "NF033777" ]

[ "M_group_A_cterm" ]

[ 65 ]

1

[]

0

[]

0

[ "PUB00105313" ]

[ "2670192" ]

[ "Streptococcal M protein: molecular design and biological behavior." ]

[ 1989 ]

1

[]

0

null

[ "Streptococcus" ]

[ 65 ]

1

[]

0

true

Domain

M protein serotype 5/6, C-terminal domain

M_group_A_cterm

2

IPR061305

61,305

MARTX multifunctional-autoprocessing repeats-in-toxin, N-terminal

MARTX_Nterm

Domain

291

false

This entry describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains [ , , ].

[]

0

[ "NCBIFAM" ]

[ "NF012221" ]

[ "MARTX_Nterm" ]

[ 291 ]

1

[]

0

[]

0

[ "PUB00053274", "PUB00105003", "PUB00105004" ]

[ "17464284", "18591243", "19620709" ]

[ "Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain.", "Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin.", "Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio ...

[ 2007, 2008, 2009 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 291 ]

1

[]

0

true

Domain

MARTX multifunctional-autoprocessing repeats-in-toxin, N-terminal

MARTX_Nterm

7

IPR061306

61,306

Spiralin lipoprotein

Spiralin_LP

Family

41

false

This entry represents Spiralin from Spiroplasma citri and similar proteins from Tenericutes. The surface of spiroplasma bacteria is crowded with the membrane-anchored lipoprotein spiralin, whose structure and function are unknown, although its cellular function is thought to be a structural and mechanical one rather th...

[]

0

[ "NCBIFAM" ]

[ "NF038030" ]

[ "spiralin_LP" ]

[ 41 ]

1

[]

0

[]

0

[ "PUB00010230", "PUB00105527", "PUB00105528" ]

[ "11988221", "16250340", "2211527" ]

[ "Secondary structure of spiralin in solution, at the air/water interface, and in interaction with lipid monolayers.", "Purification and characterization of spiralin, the main protein of the Spiroplasma citri membrane.", "Spiralins of Spiroplasma citri and Spiroplasma melliferum: amino acid sequences and putativ...

[ 2002, 1977, 1990 ]

3

[]

0

null

[ "Spiroplasma" ]

[ 41 ]

1

[]

0

true

Family

Spiralin lipoprotein

Spiralin_LP

6

IPR061307

61,307

Magnetosome protein MamO

MamO

Family

24

false

Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environment. Proteins of this family are essential in the formation of bacterial magnetosomes. MamO promotes crystal nucleat...

[]

0

[ "NCBIFAM" ]

[ "NF040961" ]

[ "MamO" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00093597", "PUB00106095", "PUB00106096" ]

[ "26981620", "35110403", "20674739" ]

[ "MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria.", "A protease-mediated switch regulates the growth of magnetosome organelles in Magnetospirillum magneticum.", "mamO and mamE genes are essential for magnetosome cry...

[ 2016, 2022, 2010 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 24 ]

1

[]

0

true

Family

Magnetosome protein MamO

MamO

4

IPR061308

61,308

Magnetosome protein MamX

MamX

Family

10

false

Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environment. Proteins of this family are involved in biomineralization through redox control [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF040996" ]

[ "MamX" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00093603", "PUB00106121" ]

[ "23889511", "24020498" ]

[ "The magnetosome proteins MamX, MamZ and MamH are involved in redox control of magnetite biomineralization in Magnetospirillum gryphiswaldense.", "MamX encoded by the mamXY operon is involved in control of magnetosome maturation in Magnetospirillum gryphiswaldense MSR-1." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Rhodospirillales" ]

[ 10 ]

1

[]

0

true

Family

Magnetosome protein MamX

MamX

8

IPR061309

61,309

Liposome tubulation protein MamY

MamY

Family

7

false

Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environment. Proteins of this family are involved in liposome tubulation during the formation of magnetosomes [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF040997" ]

[ "MamY" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00106122", "PUB00106123" ]

[ "20345667", "30039923" ]

[ "Identification and functional characterization of liposome tubulation protein from magnetotactic bacteria.", "Enhanced Tubulation of Liposome Containing Cardiolipin by MamY Protein from Magnetotactic Bacteria." ]

[ 2010, 2018 ]

2

[]

0

null

[ "Rhodospirillales" ]

[ 7 ]

1

[]

0

true

Family

Liposome tubulation protein MamY

MamY

3

IPR061310

61,310

Cytochrome b559 subunit beta, long form

PSBFL

Family

6

false

Long forms of cytochrome b559 subunit beta (PsbF) are found in Prochlorococcus.

[]

0

[ "NCBIFAM" ]

[ "NF002717" ]

[ "PRK02561.1-1" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[ "IPR006241" ]

[]

1

0

1

[ "Prochlorococcus marinus" ]

[ 6 ]

1

[]

0

true

Family

Cytochrome b559 subunit beta, long form

PSBFL

6

IPR061312

61,312

DISARM system helicase DrmA, short form

DISARM_DrmAS

Family

751

false

Members of this family are DrmA helicases from representative DISARM anti-phage gene clusters, mostly from class I systems, but a few from class II systems. This entry excludes those members of class II systems that both are divergent in sequence from this set and have a characteristic long insert [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038325" ]

[ "DISARM_DrmAS" ]

[ 751 ]

1

[]

0

[ "7s9v", "7s9w" ]

2

[ "PUB00105719" ]

[ "29085076" ]

[ "DISARM is a widespread bacterial defence system with broad anti-phage activities." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Phage sp. ctrsQ3", "metagenomes" ]

[ 747, 1, 3 ]

3

[]

0

true

Family

DISARM system helicase DrmA, short form

DISARM_DrmAS

3

IPR061313

61,313

DNA relaxase MbeA

Relax_MbeA_E1

Family

421

false

MbeA, as described in the mobilization region of the ColE1 plasmid, fully overlaps two tandem mobilization proteins on the same strand, MbeB and MbeD [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047848" ]

[ "relax_MbeA_E1" ]

[ 421 ]

1

[]

0

[]

0

[ "PUB00159609" ]

[ "12675806" ]

[ "Genetic and biochemical characterization of MbeA, the relaxase involved in plasmid ColE1 conjugative mobilization." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "uncultured prokaryote" ]

[ 414, 2, 2, 3 ]

4

[]

0

true

Family

DNA relaxase MbeA

Relax_MbeA_E1

7

IPR061316

61,316

Opacity-associated protein OapA

Opacity_OapA

Family

84

false

This family consists of full-length homologues to OapA, opacity-associated protein A as described in Haemophilus influenzae. OapA shares a C-terminal homology domain, called the OapA domain, with the Escherichia coli protein YtfB, which is now known to bind peptidoglycan through its OapA domain and to act as a cell div...

[]

0

[ "NCBIFAM" ]

[ "NF033909" ]

[ "opacity_OapA" ]

[ 84 ]

1

[]

0

[]

0

[ "PUB00094178", "PUB00105421" ]

[ "29686141", "10417187" ]

[ "YtfB, an OapA Domain-Containing Protein, Is a New Cell Division Protein in Escherichia coli.", "Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells." ]

[ 2018, 1999 ]

2

[]

0

null

[ "Pasteurellaceae" ]

[ 84 ]

1

[]

0

true

Family

Opacity-associated protein OapA

Opacity_OapA

3

IPR061317

61,317

WxPxxD membrane protein

WxPxxD_TM

Family

76

false

This uncommon, extremely hydrophobic protein of about 240 amino acids occurs sporadically in members of the Firmicutes, including the Listeria, Bacillus, Anoxybacillus, and Terribacillus genera. The protein is named for its most distinctive motif. The function is unknown, but the size and hydrophobicity suggests a tran...

[]

0

[ "NCBIFAM" ]

[ "NF035952" ]

[ "WxPxxD_TM" ]

[ 76 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 76 ]

1

[]

0

true

Family

WxPxxD membrane protein

WxPxxD_TM

5

IPR061318

61,318

TUL4 lipoprotein

OM_lipo_TUL4

Family

139

false

TUL4 family lipoproteins, including paralogues designated LpnA and LpnB, are highly expressed on the outer membrane in the genus Francisella [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038367" ]

[ "OM_lipo_TUL4" ]

[ 139 ]

1

[]

0

[]

0

[ "PUB00105749" ]

[ "1612751" ]

[ "Humoral and cell-mediated immunity in mice to a 17-kilodalton lipoprotein of Francisella tularensis expressed by Salmonella typhimurium." ]

[ 1992 ]

1

[]

0

null

[ "Thiotrichales" ]

[ 139 ]

1

[]

0

true

Family

TUL4 lipoprotein

OM_lipo_TUL4

9

IPR061319

61,319

DNA metabolism protein TP0183

TP0183_fam

Family

49

false

TP_0183 is a protein of approximately 281 amino acids that is processed from a precursor containing an N-terminal signal peptide. Protein-protein interactions of TP0183 of Treponema pallidum with DnaA, with the DNA repair helicase TP0380, and with SbcD, a protein involved in replication restart after DNA repair, sugges...

[]

0

[ "NCBIFAM" ]

[ "NF049867" ]

[ "TP0183_fam" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00162494" ]

[ "18509523" ]

[ "The binary protein interactome of Treponema pallidum--the syphilis spirochete." ]

[ 2008 ]

1

[]

0

null

[ "Spirochaetales" ]

[ 49 ]

1

[]

0

true

Family

DNA metabolism protein TP0183

TP0183_fam

2

IPR061320

61,320

Spore coat protein CotG

Spore_coat_G

Family

49

false

CotG is a lysine-rich repetitive endospore coat protein that is among the most highly charged proteins known. It is reported to mediate spore surface permeability [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047411" ]

[ "spore_coat_G" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00159445" ]

[ "36354330" ]

[ "CotG Mediates Spore Surface Permeability in Bacillus subtilis." ]

[ 2022 ]

1

[]

0

null

[ "Bacillus" ]

[ 49 ]

1

[]

0

true

Family

Spore coat protein CotG

Spore_coat_G

3

IPR061321

61,321

Calmodulin-dependent glutamylase SidJ

SidJ_poly_Glu

Family

47

false

SidJ, called a pseudokinase because its polyglutamylation activity differs from what might be expected from its kinase-like fold, is the founding member of a family of such pseudokinases. SidJ itself, as described in Legionella pneumophila, is exported by a type IV secretion system (T4SS), and modifies and modulates th...

[]

0

[ "NCBIFAM" ]

[ "NF033873" ]

[ "SidJ_poly_Glu" ]

[ 47 ]

1

[]

0

[ "6k4k", "6k4l", "6k4r", "6oqq", "6plm", "6s5t", "7mir", "7mis", "7ppo", "7pqe" ]

10

[ "PUB00105393" ]

[ "31123136" ]

[ "Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases." ]

[ 2019 ]

1

[]

0

null

[ "Legionella" ]

[ 47 ]

1

[]

0

true

Family

Calmodulin-dependent glutamylase SidJ

SidJ_poly_Glu

8

IPR061322

61,322

ArtA-dependent S-layer glycoprotein, Haloferax gibbonsii-type

Surf_glcprot_Halo

Family

15

false

S-layer (surface layer) proteins form a paracrystalline surface layer in most archaea and some bacteria. A number of different, unrelated families exist. Members of these families typically are glycoproteins, often with extensive post-translational modification. This entry includes the cell surface glycoprotein from Ha...

[]

0

[ "NCBIFAM" ]

[ "NF041335" ]

[ "surf_glcprot_Halo" ]

[ 15 ]

1

[]

0

[]

0

[ "PUB00060405", "PUB00106339" ]

[ "22037399", "29558455" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification.", "Comparative Analysis of Surface Layer Glycoproteins and Genes Involved in Protein Glycosylation in the Genus Haloferax." ]

[ 2012, 2018 ]

2

[]

0

null

[ "Haloferax" ]

[ 15 ]

1

[]

0

true

Family

ArtA-dependent S-layer glycoprotein, Haloferax gibbonsii-type

Surf_glcprot_Halo

1

IPR061323

61,323

IgA Fc-binding protein BAC

GBS_IgA_bnd_BAC

Family

11

false

The IgA Fc-region binding protein of Streptococcus agalactiae (group B streptococcus) is a surface-anchored virulence factor with a YSIRK-type signal sequence at the N-terminal and an LPXTG sorting signal near the C-terminal. It is also called beta-antigen [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF038253" ]

[ "GBS_IgA_bnd_BAC" ]

[ 11 ]

1

[]

0

[]

0

[ "PUB00105667", "PUB00105668" ]

[ "17004655", "26047354" ]

[ "Adjacent location of the bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island.", "Natural Mutations in Streptococcus agalactiae Resulting in Abrogation of β Antigen Production." ]

[ 2006, 2015 ]

2

[]

0

null

[ "Streptococcus" ]

[ 11 ]

1

[]

0

true

Family

IgA Fc-binding protein BAC

GBS_IgA_bnd_BAC

3

IPR061324

61,324

Type V CRISPR-associated effector Cas12f2

CRISPR_Cas12f2

Family

2

false

Members of this family belong to the Cas12f2 subfamily of the type V CRISPR-associated effector Cas12. Note that members of this family at one time called Cas14 (see ), but based on recent reviews, the term Cas14 now belongs to the unrelated family found in type VII CRISPR systems.

[]

0

[ "NCBIFAM" ]

[ "NF049972" ]

[ "CRISPR_Cas12f2" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00162584" ]

[ "30337455" ]

[ "Programmed DNA destruction by miniature CRISPR-Cas14 enzymes." ]

[ 2018 ]

1

[]

0

null

[ "Micrarchaeota archaeon (strain CG1_02_47_40)", "Thermodesulfobacterium geofontis" ]

[ 1, 1 ]

2

[]

0

true

Family

Type V CRISPR-associated effector Cas12f2

CRISPR_Cas12f2

5

IPR061325

61,325

LETM1-related biofilm-associated protein

LETM1-rel_film

Family

677

false

This bacterial protein family is related to the mitochondrial protein LETM1. The founding member from the fish pathogen Flavobacterium columnare, called a calcium-binding EF hand protein, was found highly up-regulated in expression during biofilm formation [ ].

[]

0

[ "NCBIFAM" ]

[ "NF040639" ]

[ "LETM1_rel_film" ]

[ 677 ]

1

[]

0

[]

0

[ "PUB00105865" ]

[ "31272369" ]

[ "Transcriptome analysis of the fish pathogen Flavobacterium columnare in biofilm suggests calcium role in pathogenesis." ]

[ 2019 ]

1

[]

0

null

[ "Flavobacteriales", "ecological metagenomes" ]

[ 674, 3 ]

2

[]

0

true

Family

LETM1-related biofilm-associated protein

LETM1-rel_film

6

IPR061326

61,326

CLCA_X

Family

615

false

CLCAs, named for calcium-activated chloride channel bCLCA1, are proteins that resemble certain zinc-dependent metalloproteases in fold by lacking the signature HEXXH motifs. The CLCA_X family, described by this entry, was identified based on weak similarities [ ] as a notable CLCA-like family with a consistent architec...

[]

0

[ "NCBIFAM" ]

[ "NF041907" ]

[ "CLCA_X" ]

[ 615 ]

1

[]

0

[]

0

[ "PUB00075429", "PUB00091133" ]

[ "23671590", "28559295" ]

[ "CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites.", "Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements." ]

[ 2013, 2017 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 610, 5 ]

2

[]

0

true

Family

CLCA_X

7

IPR061327

61,327

Adhesin RatB

RatB

Family

640

false

RatB, encoded in a Salmonella pathogenicity island next to its homologue RatA, is a long protein consisting almost entirely of repeats of a and [ ]. The domain is also found in the inverse autotransporter adhesin/invasin, where it is called an adhesion domain. The domain is a Bacterial Immunoglobulin-like domain, BIg21...

[]

0

[ "NCBIFAM" ]

[ "NF011842" ]

[ "PRK15314.1" ]

[ 640 ]

1

[]

0

[]

0

[ "PUB00016646" ]

[ "12540539" ]

[ "Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants." ]

[ 2003 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 640 ]

1

[]

0

true

Family

Adhesin RatB

RatB

8

IPR061328

61,328

Bdr-like, N-terminal domain

Bdr_N_group1

Domain

514

false

Bdr (Borrelia direct repeat) proteins have an N-terminal domain, a variable length region of repeats, typically 11 amino acids long with a KID repeat, and a non-repetitive C-terminal domain. This entry describes the conserved N-terminal domain of families designated BdrA, BdrB, and BdrC [ ]. A related but non-overlappi...

[]

0

[ "NCBIFAM" ]

[ "NF040499" ]

[ "Bdr_N_group1" ]

[ 514 ]

1

[]

0

[]

0

[ "PUB00105795" ]

[ "10644495" ]

[ "Evolutionary and molecular analyses of the Borrelia bdr super gene family: delineation of distinct sub-families and demonstration of the genus wide conservation of putative functional domains, structural properties and repeat motifs." ]

[ 2000 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 514 ]

1

[]

0

true

Domain

Bdr-like, N-terminal domain

Bdr_N_group1

8

IPR061329

61,329

CBS-HotDog domain-containing transcription factor SpxR

TF_CBS_SpxR

Family

389

false

SpxR from Streptococcus pneumoniae, like its full-length homologue YtoI from Listeria monocytogenes, is a transcriptional regulator with an N-terminal DNA-binding domain, and with CBS and HotDog domains. SpxR regulates the pyruvate oxidase SpxB [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038279" ]

[ "TF_CBS_SpxR" ]

[ 389 ]

1

[]

0

[]

0

[ "PUB00105694" ]

[ "18179423" ]

[ "Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura" ]

[ 388, 1 ]

2

[]

0

true

Family

CBS-HotDog domain-containing transcription factor SpxR

TF_CBS_SpxR

6

IPR061330

61,330

Exc2 lipoprotein-like

Exc2_fam

Family

380

false

Exc2, a plasmid-encoded predicted lipoprotein of small size, was once described as a plasmid entry exclusion protein [ ]. However, [ ], says entry exclusion activity should instead be ascribed to MbeD.

[]

0

[ "NCBIFAM" ]

[ "NF033828" ]

[ "entry_exc2_fam" ]

[ 380 ]

1

[]

0

[]

0

[ "PUB00105356", "PUB00105357" ]

[ "2991225", "7592368" ]

[ "Nucleotide sequence and gene organization of ColE1 DNA.", "A ColE1-encoded gene directs entry exclusion of the plasmid." ]

[ 1985, 1995 ]

2

[]

0

null

[ "Bacteria" ]

[ 380 ]

1

[]

0

true

Family

Exc2 lipoprotein-like

Exc2_fam

4

IPR061334

61,334

Putative pilus system protein FilA

Pilus_FilA

Family

218

false

FilA is found almost exclusively in the genus Acinetobacter and is assigned as a putative pilus assembly protein from local genomic contexts that include several additional putative pilus system proteins [ ].

[]

0

[ "NCBIFAM" ]

[ "NF050077" ]

[ "pilus_FilA" ]

[ 218 ]

1

[]

0

[]

0

[ "PUB00162658" ]

[ "29939498" ]

[ "Transcriptome analysis of Porphyromonas gingivalis and Acinetobacter baumannii in polymicrobial communities." ]

[ 2018 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 218 ]

1

[]

0

true

Family

Putative pilus system protein FilA

Pilus_FilA

8

IPR061335

61,335

BREX-1 system phosphatase PglZ, type B

BREX_PglZ_1_B

Family

217

false

BREX (bacteriophage exclusion) is a phage resistance resistance, in which two protein families are core but other proteins are variable. BREX subtypes are based on PglZ domain protein, a putative phosphatase. This family is one of two major subtypes of PglZ as seen in type 1 BREX systems [ ]. describes the alternative ...

[]

0

[ "NCBIFAM" ]

[ "NF033450" ]

[ "BREX_PglZ_1_B" ]

[ 217 ]

1

[]

0

[]

0

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Methanomicrobia", "ecological metagenomes" ]

[ 203, 9, 5 ]

3

[]

0

true

Family

BREX-1 system phosphatase PglZ, type B

BREX_PglZ_1_B

6

IPR061336

61,336

Hormogonium tapered terminus morphoprotein TftA

Horm_taper_TftA

Family

204

false

TftA, an amidase that can act on peptidoglycan, is found strictly in a subset of the Cyanobacteria, where it is required for the proper morphology of hormogonia (mobile colony filaments), which normally are tapered at both ends [ ].

[]

0

[ "NCBIFAM" ]

[ "NF050040" ]

[ "horm_taper_TftA" ]

[ 204 ]

1

[]

0

[]

0

[ "PUB00162599" ]

[ "37971486" ]

[ "Identification of a morphogene required for tapered filament termini in filamentous cyanobacteria." ]

[ 2023 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 204 ]

1

[]

0

true

Family

Hormogonium tapered terminus morphoprotein TftA

Horm_taper_TftA

2

IPR061337

61,337

Phage exclusion lipoprotein Cor-like

Lamb_exclu_cor

Family

201

false

The lipoprotein Cor, as found in temperate lambdoid phage that depend on FhuA as a phage receptor, functions in phage exclusion through its interaction with FhuA [ , ]. This entry also includes uncharacterised bacterial sequences.

[]

0

[ "NCBIFAM" ]

[ "NF047972" ]

[ "lamb_exclu_cor" ]

[ 201 ]

1

[]

0

[]

0

[ "PUB00162644", "PUB00162645", "PUB00162646" ]

[ "30043202", "15518820", "8631731" ]

[ "Cor interacts with outer membrane proteins to exclude FhuA-dependent phages.", "An orthologue of the cor gene is involved in the exclusion of temperate lambdoid phages. Evidence that Cor inactivates FhuA receptor functions.", "Proteins responsible for lysogenic conversion caused by coliphages N15 and phi80 are...

[ 2018, 2004, 1996 ]

3

[]

0

null

[ "Caudoviricetes", "Enterobacterales" ]

[ 88, 113 ]

2

[]

0

true

Family

Phage exclusion lipoprotein Cor-like

Lamb_exclu_cor

6