LiteFold/InterPro · Datasets at Hugging Face

IPR060976

60,976

Type 6 secretion system effector deamidase TecA

T6SS_VF_TecA

Family

60

false

TecA (T6SS effector protein affecting cytoskeletal architecture), a type 6 secretion system effector confirmed as a virulence factor of Burkholderia cepacia in a mouse model, is a deamidase that inactivates RhoA and other Rho GTPases in host cells [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF040972" ]

[ "T6SS_VF_TecA" ]

[ 60 ]

1

[]

0

[]

0

[ "PUB00106102", "PUB00106103" ]

[ "27133449", "34579569" ]

[ "A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.", "The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection." ]

[ 2016, 2021 ]

2

[]

0

null

[ "Burkholderia" ]

[ 60 ]

1

[]

0

true

Family

Type 6 secretion system effector deamidase TecA

T6SS_VF_TecA

3

IPR060978

60,978

SSU0592/SSU0593-like

SSU0592/3-like

Family

59

false

Members of this family appear restricted to Streptococcus suis, but several tandem copies are found, e.g. SSU0592, SSU0593, and SSU0594. The N-terminal region, with an apparent signal peptide or signal-anchor sequence, is well conserved, but the rest shows variability.

[]

0

[ "NCBIFAM" ]

[ "NF046094" ]

[ "SSU0593_fam" ]

[ 59 ]

1

[]

0

[]

0

[ "PUB00159180" ]

[ "26110524" ]

[ "Isolation, Characterization and Biological Properties of Membrane Vesicles Produced by the Swine Pathogen Streptococcus suis." ]

[ 2015 ]

1

[]

0

null

[ "Streptococcus suis" ]

[ 59 ]

1

[]

0

true

Family

SSU0592/SSU0593-like

SSU0592/3-like

7

IPR060982

60,982

Microaggregate invasion protein-1

MIP-1

Family

57

false

MIP-1 (Microaggregate invasion protein-1, ) was shown to be associated with the invasion of Mycobacterium avium subsp. hominissuis into HEp-2 epithelial cells in part through its interaction with the host protein filamin A [ ].

[]

0

[ "NCBIFAM" ]

[ "NF050176" ]

[ "MIP-1" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00162828" ]

[ "26252358" ]

[ "Microaggregate-associated protein involved in invasion of epithelial cells by Mycobacterium avium subsp. hominissuis." ]

[ 2015 ]

1

[]

0

null

[ "Caudoviricetes", "Mycobacteriaceae" ]

[ 48, 9 ]

2

[]

0

true

Family

Microaggregate invasion protein-1

MIP-1

7

IPR060983

60,983

MAG5620-like putative phospho-sugar mutase

MAG5620-like

Family

58

false

Members of this family, restricted to the Mycoplasmatota, are uncharacterised, but show distant homology to phosphomannomutases and phosphoglucomutases.

[]

0

[ "NCBIFAM" ]

[ "NF045968" ]

[ "mutase_MAG5620" ]

[ 58 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 58 ]

1

[]

0

true

Family

MAG5620-like putative phospho-sugar mutase

MAG5620-like

8

IPR060987

60,987

Choice-of-anchor N domain

Choice_anch_N

Domain

54

false

The choice-of-anchor N domain occurs in mainly in bacteria a PEP-CTERM sorting signal at the C terminus. Well-conserved motifs in the multiple sequence alignment include AxPxLQ near the N terminus, and HFD and PxSHD near the C terminus, the latter just upstream of the sorting signal region.

[]

0

[ "NCBIFAM" ]

[ "NF038141" ]

[ "choice_anch_N" ]

[ 54 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 51, 3 ]

2

[]

0

true

Domain

Choice-of-anchor N domain

Choice_anch_N

4

IPR060989

60,989

Lmo0654-like

Family

53

false

Members of this family of small proteins (about 67 amino acids long) are found in multiple species of Listeria species, including Lmo0654 ( ), which was shown to be regulated by sigma factor SigB. The family shows apparent homology to SE1832 family proteins (see ), whose members are also found in Gram-positive bacteria...

[]

0

[ "NCBIFAM" ]

[ "NF041889" ]

[ "Lmo0654_fam" ]

[ 53 ]

1

[]

0

[]

0

[ "PUB00152917" ]

[ "18564909" ]

[ "SigmaB- and PrfA-dependent transcription of genes previously classified as putative constituents of the Listeria monocytogenes PrfA regulon." ]

[ 2008 ]

1

[]

0

null

[ "Listeria" ]

[ 53 ]

1

[]

0

true

Family

Lmo0654-like

2

IPR060992

60,992

Putative inclusion membrane protein CT214-like

CT214-like

Family

52

false

Members of this family of Chlamydia putative inclusion membrane proteins include CT214 from C.trachomatis ( ) [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF047333" ]

[ "Chlam_inc_CT214" ]

[ 52 ]

1

[]

0

[]

0

[ "PUB00159817", "PUB00159818" ]

[ "26416906", "37747235" ]

[ "Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis.", "Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference." ]

[ 2015, 2023 ]

2

[]

0

null

[ "Chlamydia" ]

[ 52 ]

1

[]

0

true

Family

Putative inclusion membrane protein CT214-like

CT214-like

8

IPR060999

60,999

Adventurous gliding motility protein CglF-like

CglF-like

Family

49

false

This protein family includes CglF from Myxococcus xanthus ( ), a gliding motility protein. It has the property that motility in a cglF loss mutant can be restored by close contact with compatible kin strains where cglF is wild type. The restoration of motility depends on bidirectional kinship recognition, which is medi...

[]

0

[ "NCBIFAM" ]

[ "NF033764" ]

[ "gliding_CglF" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00105302" ]

[ "22343295" ]

[ "Identification of the cglC, cglD, cglE, and cglF genes and their role in cell contact-dependent gliding motility in Myxococcus xanthus." ]

[ 2012 ]

1

[]

0

null

[ "Cystobacterineae" ]

[ 49 ]

1

[]

0

true

Family

Adventurous gliding motility protein CglF-like

CglF-like

9

IPR061000

61,000

MAG6090-like domain

MAG6090-like_dom

Domain

51

false

This short domain, often tandemly repeated, is observed only in surface lipoproteins of wall-less mycoplasmoidales and mycoplasmatales, including MAG6090 from Mycoplasmopsis agalactiae ( ).

[]

0

[ "NCBIFAM" ]

[ "NF045950" ]

[ "MAG6090_repeat" ]

[ 51 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 51 ]

1

[]

0

true

Domain

MAG6090-like domain

MAG6090-like_dom

9

IPR061001

61,001

Darobactin-like, putative

Darobactin-like_put

Family

50

false

Darobactin, discovered in the genus Photorhabdus, is a peptide antibiotic, made from a ribosomally translated precursor, and modified by the radical SAM/SPASM peptide maturase DarE. Darobactin A is the founding member of a new class of antibiotic that appears to target BamA, a component of the outer membrane β -barrel ...

[]

0

[ "NCBIFAM" ]

[ "NF038004" ]

[ "darobactin_RiPP" ]

[ 50 ]

1

[]

0

[]

0

[ "PUB00105507" ]

[ "31747680" ]

[ "A new antibiotic selectively kills Gram-negative pathogens." ]

[ 2019 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 50 ]

1

[]

0

true

Family

Darobactin-like, putative

Darobactin-like_put

3

IPR061004

61,004

EPS-associated small membrane protein EppA

EppA

Family

51

false

EppA (EPS Pea-dependent phenotypes A) is a small protein required for the nearby "pea" operon for exopolysaccharide biosynthesis to be able to cause a pea-like wrinkled colony morphology. The C-terminal domain of this 58-amino acid protein has a high degree of sequence similarity with the VPLPA-CTERM, which has the cog...

[]

0

[ "NCBIFAM" ]

[ "NF046088" ]

[ "anchor_EppA" ]

[ 51 ]

1

[]

0

[]

0

[ "PUB00159136" ]

[ "34985979" ]

[ "Second Messenger c-di-GMP Modulates Exopolysaccharide Pea-Dependent Phenotypes via Regulation of eppA Expression in Pseudomonas putida." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonas" ]

[ 51 ]

1

[]

0

true

Family

EPS-associated small membrane protein EppA

EppA

5

IPR061005

61,005

Tryptorubin family RiPP precursor

Tryptorubin_pre

Family

46

false

Tryptorubin A is the founding member of the atropitides, a class of polycyclic RiPP natural product featuring crosslinks through aromatic amino acids.

[]

0

[ "NCBIFAM" ]

[ "NF038372" ]

[ "tryptorubin_fam" ]

[ 46 ]

1

[]

0

[]

0

[ "PUB00105754", "PUB00105755" ]

[ "28853867", "32935693" ]

[ "Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.", "New developments in RiPP discovery, enzymology and engineering." ]

[ 2017, 2021 ]

2

[]

0

null

[ "Bacteria" ]

[ 46 ]

1

[]

0

true

Family

Tryptorubin family RiPP precursor

Tryptorubin_pre

9

IPR061006

61,006

SPIN-like peroxidase inhibitor

Perox_inhi_SPIN-like

Family

47

false

SPIN (staphylococcal peroxidase inhibitor) binds to and inhibits human myeloperoxidase to resist killing after phagocytosis by neutrophils.

[]

0

[ "NCBIFAM" ]

[ "NF033694" ]

[ "perox_inhi_SPIN" ]

[ 47 ]

1

[]

0

[ "5uzu", "6azp", "6bmt", "7qzr", "7z53", "9bd0", "9qe3", "9qex", "9qga", "9qj3", "9qjo", "9sds" ]

12

[ "PUB00105249", "PUB00105250" ]

[ "28808028", "29524428" ]

[ "Immune evasion by a staphylococcal inhibitor of myeloperoxidase.", "Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini." ]

[ 2017, 2018 ]

2

[]

0

null

[ "Staphylococcaceae" ]

[ 47 ]

1

[]

0

true

Family

SPIN-like peroxidase inhibitor

Perox_inhi_SPIN-like

8

IPR061007

61,007

YhhA-like cyclophane-containing RiPP

RIPP_cyclo_YhhA

Family

46

false

Members of this family are triceptide-type riibosomally translated, post-translationally modified peptide natural products (RiPPs). Maturation begins with a cyclophane-forming cyclization in the YxRxHxRHxR motif of the core region by a radical SAM/SPASM enzyme, called YhhB, followed by hydroxylation by a 2OG-Fe(II) oxy...

[]

0

[ "NCBIFAM" ]

[ "NF041705" ]

[ "RIPP_cyclo_YhhA" ]

[ 46 ]

1

[]

0

[ "9gmc" ]

1

[ "PUB00152923" ]

[ "35729768" ]

[ "The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria" ]

[ 46 ]

1

[]

0

true

Family

YhhA-like cyclophane-containing RiPP

RIPP_cyclo_YhhA

1

IPR061010

61,010

Bacteriocin-like WGxF protein

WGxF-like

Family

46

false

Members of this protein family of hydrophobic proteins about 60 amino acids long are found in firmicutes in three-gene contexts that suggest a role as a bacteriocin or an immunity protein. The protein is named for its most striking sequence feature, a nearly invariant WGxF motif.

[]

0

[ "NCBIFAM" ]

[ "NF037932" ]

[ "ocin_sys_WGxF" ]

[ 46 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 46 ]

1

[]

0

true

Family

Bacteriocin-like WGxF protein

WGxF-like

6

IPR061012

61,012

Type I toxin-antitoxin system toxin

CD_typeI_toxin

Family

49

false

A type I toxin-antitoxin system typically consists of a small hydrophobic toxic protein and an antisense RNA, which forms RNA duplex with the toxin-encoding mRNA to inhibit toxin translation. Members of this family are small type I toxin-antitoxin system toxin proteins mainly found in Clostridium difficile. Their encod...

[]

0

[ "NCBIFAM" ]

[ "NF047374" ]

[ "CD_typeI_toxin" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00159309", "PUB00159310" ]

[ "33247281", "29529286" ]

[ "Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile.", "Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile." ]

[ 2020, 2018 ]

2

[]

0

null

[ "Caudoviricetes", "Clostridioides difficile" ]

[ 16, 33 ]

2

[]

0

true

Family

Type I toxin-antitoxin system toxin

CD_typeI_toxin

6

IPR061013

61,013

UpsX

Family

46

false

Proteins of this family are encoded by the archaeal upsX gene on the UV-inducible pili operon (ups operon), which is involved in UV-induced pili assembly, cellular aggregation, and subsequent DNA exchange between cells. UspX is not structurally essential for UV-induced pili formation and cellular aggregation, but appea...

[]

0

[ "NCBIFAM" ]

[ "NF046072" ]

[ "UpsX" ]

[ 46 ]

1

[]

0

[]

0

[ "PUB00159058" ]

[ "24106028" ]

[ "Molecular analysis of the UV-inducible pili operon from Sulfolobus acidocaldarius." ]

[ 2013 ]

1

[]

0

null

[ "Sulfolobaceae" ]

[ 46 ]

1

[]

0

true

Family

UpsX

4

IPR061015

61,015

HaaA-like cyclophane-containing RiPP peptide

RiPP_phane_HaaA

Family

45

false

HaaA is a ribosomally translated, post-translationally modified peptide (RiPP) identified as a triceptide, that is, a peptide in which the side chains of two nearby amino acids are cross-linked to form a strained three-amino acid cyclophane moiety. The modification pathway for HaaA family triceptides is thought similar...

[]

0

[ "NCBIFAM" ]

[ "NF041708" ]

[ "RiPP_phane_HaaA" ]

[ 45 ]

1

[]

0

[]

0

[ "PUB00152923" ]

[ "35729768" ]

[ "The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs." ]

[ 2022 ]

1

[]

0

null

[ "Streptomycetaceae" ]

[ 45 ]

1

[]

0

true

Family

HaaA-like cyclophane-containing RiPP peptide

RiPP_phane_HaaA

1

IPR061016

61,016

T3SS regulon translocated regulator ExsE2-like

ExsE2-like

Family

48

false

ExsE2, as described in two Vibrio species, is called functionally equivalent to ExsE from Pseudomonas aeruginosa, but appears to lack detectable sequence homology. In each model organism, a type III secretion system (T3SS) contains a DNA-binding transcriptional activator ExsA, an anti-activator ExsD that binds ExsA and...

[]

0

[ "NCBIFAM" ]

[ "NF033907" ]

[ "ExsE2_fam" ]

[ 48 ]

1

[]

0

[]

0

[ "PUB00105417", "PUB00105418" ]

[ "22767546", "27999769" ]

[ "Vibrio parahaemolyticus ExsE is requisite for initial adhesion and subsequent type III secretion system 1-dependent autophagy in HeLa cells.", "ExsE Is a Negative Regulator for T3SS Gene Expression in Vibrio alginolyticus." ]

[ 2012, 2016 ]

2

[]

0

null

[ "Vibrionaceae" ]

[ 48 ]

1

[]

0

true

Family

T3SS regulon translocated regulator ExsE2-like

ExsE2-like

5

IPR061017

61,017

Ammosamide/lymphostin biosynthesis, leader domain

Amm_Lyn_leader

Domain

44

false

Precursors of the ammosamide (Amm6) and lymphostin family of natural products share both a strongly conserved leader peptide region (represented by this entry) that interacts with natural product biosynthesis enzymes, and a critical Trp residue at or near the C terminus that is incorporated into the small molecule natu...

[]

0

[ "NCBIFAM" ]

[ "NF033737" ]

[ "Amm_Lyn_leader" ]

[ 44 ]

1

[]

0

[]

0

[ "PUB00105285" ]

[ "27866908" ]

[ "Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria" ]

[ 44 ]

1

[]

0

true

Domain

Ammosamide/lymphostin biosynthesis, leader domain

Amm_Lyn_leader

4

IPR061024

61,024

SAS049

Family

41

false

This family of small proteins includes SAS049 from Staphylococcus aureus , SE1307 from Staphylococcus epidermidis , and closely related proteins from other staphylococcal species. The N-terminal region appears highly similar to Rv0909 from Mycobacterium tuberculosis , which appears to be the antitoxin member of a novel...

[]

0

[ "NCBIFAM" ]

[ "NF040846" ]

[ "SAS049_fam" ]

[ 41 ]

1

[]

0

[]

0

[ "PUB00105616", "PUB00106012" ]

[ "23554199", "34061833" ]

[ "Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages.", "Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach....

[ 2013, 2021 ]

2

[]

0

null

[ "Staphylococcus" ]

[ 41 ]

1

[]

0

true

Family

SAS049

3

IPR061025

61,025

Peptide pheromone VP1

Pheromone_VP1

Family

40

false

This entry represents peptide pheromone VP1 . VP1 (virulence peptide 1), as characterised in Streptococcus pneumoniae (a.k.a. pneumococcus), is part of a large panel of secreted regulatory peptides with paralogous leader domains, typically ending with the cleavage site GlyGly, but with highly variable core regions. VP1...

[]

0

[ "NCBIFAM" ]

[ "NF033772" ]

[ "pheromone_VP1" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00105309" ]

[ "28557053" ]

[ "A novel streptococcal cell-cell communication peptide promotes pneumococcal virulence and biofilm formation." ]

[ 2017 ]

1

[]

0

null

[ "Streptococcus" ]

[ 40 ]

1

[]

0

true

Family

Peptide pheromone VP1

Pheromone_VP1

7

IPR061026

61,026

IncB, C-terminal domain

IncB_C

Domain

39

false

This entry represents the C-terminal region of IncB , an inclusion membrane protein from Chlamydia. When Chlamydia invades a host cell, it resides within a vacuole whose host-derived membrane is called the inclusion membrane. The chlamydial type III secretion system delivers IncB and other effector proteins into this m...

[]

0

[ "NCBIFAM" ]

[ "NF033935" ]

[ "inclusion_IncB" ]

[ 39 ]

1

[]

0

[]

0

[ "PUB00105439", "PUB00105440" ]

[ "24751478", "30848236" ]

[ "Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin.", "Make It a Sweet Home: Responses of Chlamydia trachomatis to the Challenges of an Intravacuolar Lifestyle." ]

[ 2014, 2019 ]

2

[]

0

null

[ "Chlamydia" ]

[ 39 ]

1

[]

0

true

Domain

IncB, C-terminal domain

IncB_C

7

IPR061027

61,027

Mobility-associated LCxxNW protein

LCxxNW

Family

40

false

This protein belongs to a family of small proteins, about 65 amino acids long, with three invariant Cys residues, including one in the motif LCxxNW, for which the family is named. Member proteins are found in contexts that suggest they are accessory proteins of mobile elements. The context includes proteins belonging t...

[]

0

[ "NCBIFAM" ]

[ "NF033850" ]

[ "LCxxNW" ]

[ 40 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "uncultured prokaryote" ]

[ 39, 1 ]

2

[]

0

true

Family

Mobility-associated LCxxNW protein

LCxxNW

2

IPR061028

61,028

SidJ-related pseudokinase

SidJ-rel_pseudo

Family

39

false

Members of this family are still uncharacterised, but they share strong local sequence similarity with SidJ , a protein that adopts a protein kinase-like fold yet performs a different catalytic function. In SidJ, this function is polyglutamylation, whereas the enzymatic activity of this family remains unknown [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033874" ]

[ "SidJ_rel_pseudo" ]

[ 39 ]

1

[]

0

[]

0

[ "PUB00105393" ]

[ "31123136" ]

[ "Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases." ]

[ 2019 ]

1

[]

0

null

[ "Thermodesulfobacteriota" ]

[ 39 ]

1

[]

0

true

Family

SidJ-related pseudokinase

SidJ-rel_pseudo

7

IPR061030

61,030

HYxxLL-motif containing

HYxxLL-motif_fam

Family

43

false

This family is uncharacterised, it is found in bacteria.

[]

0

[ "NCBIFAM" ]

[ "NF038143" ]

[ "HYxxLL" ]

[ 43 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 38, 5 ]

2

[]

0

true

Family

HYxxLL-motif containing

HYxxLL-motif_fam

4

IPR061032

61,032

NuoF-like, prefix N-terminal domain

NuoF-like_pre_N

Domain

35

false

This entry represents a rare N-terminal extension to NADH-quinone oxidoreductase subunit NuoF and similar proteins. This domain of about 50 residues and contains seven invariant Cys residues.

[]

0

[ "NCBIFAM" ]

[ "NF040902" ]

[ "NuoF_pre_CCxxC" ]

[ 35 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 35 ]

1

[]

0

true

Domain

NuoF-like, prefix N-terminal domain

NuoF-like_pre_N

7

IPR061033

61,033

Streptamidine-related RiPP repeat

AmiA_RiPP2x

Family

34

false

This entry represents a family of streptamidine-related RiPP precursor proteins, most of which have two or more repeats and contain the modification site. Modification is performed by a YcaO family peptide maturase. The related model describes the family of RiPP precursor proteins that includes streptamidine (AmiA) its...

[]

0

[ "NCBIFAM" ]

[ "NF040715" ]

[ "AmiA_rel_RiPP2x" ]

[ 34 ]

1

[]

0

[]

0

[ "PUB00105927" ]

[ "34659714" ]

[ "Discovery and characterisation of an amidine-containing ribosomally-synthesised peptide that is widely distributed in nature." ]

[ 2021 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 34 ]

1

[]

0

true

Family

Streptamidine-related RiPP repeat

AmiA_RiPP2x

9

IPR061035

61,035

IglJ

Family

33

false

This entry represents IglJ (intracellular growth locus J), encoded in the type VI secretion system (T6SS) of Francisella tularensis. This protein is a characterised component of the baseplate in a lineage-specific form of the T6SS apparatus [ , ]

[]

0

[ "NCBIFAM" ]

[ "NF041243" ]

[ "T6SS_IglJ" ]

[ 33 ]

1

[]

0

[]

0

[ "PUB00106256", "PUB00106257" ]

[ "32884055", "36036641" ]

[ "Using proteomics to identify host cell interaction partners for VgrG and IglJ.", "Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 33 ]

1

[]

0

true

Family

IglJ

1

IPR061039

61,039

Fur-regulated basic protein FbpC

FbpC

Family

36

false

Members of this family are FbpC, Fur-regulated basic protein C . This protein has also been described as MrgC (metal-regulated gene C). Members of this family are found in Bacillus [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF033217" ]

[ "Fur_reg_FbpC" ]

[ 36 ]

1

[]

0

[]

0

[ "PUB00075677", "PUB00105031" ]

[ "18697947", "8396117" ]

[ "The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.", "Metalloregulation in Bacillus subtilis: isolation and characterization of two genes differentially repressed by metal ions." ]

[ 2008, 1993 ]

2

[]

0

null

[ "Bacillus" ]

[ 36 ]

1

[]

0

true

Family

Fur-regulated basic protein FbpC

FbpC

8

IPR061040

61,040

Ruminococcin C1

RumC

Family

32

false

This entry represents Ruminococcin C1 from Ruminococcus gnavus and closely related radical SAM/SPASM-modified sactipeptide bacteriocins. This bacteriocin is produced by a human gut symbiont and is notable for its strong anti-clostridial activity. Homologues of RumC1 are typically about 65 amino acids long and contain f...

[]

0

[ "NCBIFAM" ]

[ "NF035950" ]

[ "RumC_sactiRiPP" ]

[ 32 ]

1

[]

0

[ "6t33" ]

1

[ "PUB00105467" ]

[ "31337708" ]

[ "Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota Ruminococcus gnavus." ]

[ 2019 ]

1

[]

0

null

[ "Clostridia" ]

[ 32 ]

1

[]

0

true

Family

Ruminococcin C1

RumC

4

IPR061042

61,042

CJH_07325

Family

33

false

This entry represents uncharacterised protein CJH_07325 ( ) and homologues. These proteins are around 70 amino acids in length and expressed in Campylobacter, Helicobacter and viruses. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF033604" ]

[ "epsi_CJH_07325" ]

[ 33 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Campylobacterales", "Connertonviridae" ]

[ 12, 21 ]

2

[]

0

true

Family

CJH_07325

5

IPR061045

61,045

LSEI_2386-like

Family

31

false

This entry represents putative pheromones including LSEI_2386 . This protein also showed bacteriocin activity against several Listeria species. This entry includes class II bacteriocin-like peptides found initially in Lactobacillus and Lacticaseibacillus. A central GG motif shows the presumptive cleavage site between t...

[]

0

[ "NCBIFAM" ]

[ "NF046113" ]

[ "BLP_Lacticasei" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00159703" ]

[ "22688903" ]

[ "Characterization of putative class II bacteriocins identified from a non-bacteriocin-producing strain Lactobacillus casei ATCC 334." ]

[ 2013 ]

1

[]

0

null

[ "Lactobacillaceae" ]

[ 31 ]

1

[]

0

true

Family

LSEI_2386-like

3

IPR061046

61,046

CPj0783

Family

30

false

Proteins of this family are inclusion-associated proteins in Chlamydia. It has been shown that protein CPj0783 was localised on Chlamydial inclusion. CPj0783 interacted with host Huntingtin-protein14, which may play an important role in disturbing the vesicle transport system to escape host lysosomal or autophagosomal ...

[]

0

[ "NCBIFAM" ]

[ "NF038014" ]

[ "Chlamy_inclu_1" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00105511" ]

[ "27611675" ]

[ "Chlamydia pneumoniae CPj0783 interaction with Huntingtin-protein14." ]

[ 2015 ]

1

[]

0

null

[ "Chlamydia" ]

[ 30 ]

1

[]

0

true

Family

CPj0783

9

IPR061050

61,050

SAOUHSC_02157

Family

29

false

Members of this family (termed SAOUHSC_02157) are restricted to the genus Staphylococcus and usually are encoded near the pmtABCD genes for the subunits of an ABC transporter that exports phenol-soluble modulins. These proteins average just 32 amino acids in length, and are generally hydrophobic, but typically contain ...

[]

0

[ "NCBIFAM" ]

[ "NF047567" ]

[ "SAOUHSC_02157" ]

[ 29 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Staphylococcus" ]

[ 29 ]

1

[]

0

true

Family

SAOUHSC_02157

1

IPR061051

61,051

Putative phage replication protein

Podovir_small

Family

31

false

This entry represents proteins which are very small and highly hydrophobic, mostly found in Acinetobacter. One member is encoded in the Podoviral Bacteriophage YMC/09/02/B1251 ABA BP [ ] (although the coding region is not predicted in GenBank record JX403940.1). Evidence suggesting the reading frame really does encode ...

[]

0

[ "NCBIFAM" ]

[ "NF033492" ]

[ "podovir_small" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00105136" ]

[ "23087105" ]

[ "Complete genome sequence of the podoviral bacteriophage YMC/09/02/B1251 ABA BP, which causes the lysis of an OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolate from a septic patient." ]

[ 2012 ]

1

[]

0

null

[ "Acinetobacter", "Acinetobacter phage YMC11/11/R3177" ]

[ 30, 1 ]

2

[]

0

true

Family

Putative phage replication protein

Podovir_small

2

IPR061052

61,052

AcrIIA3

Family

30

false

This entry represents AcrIIA3 ( ) which is an anti-CRISPR protein that prevents Cas9-containing CRISPR systems from protecting against phage infection [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033948" ]

[ "AcrIIA3_fam" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00105451" ]

[ "28041849" ]

[ "Inhibition of CRISPR-Cas9 with Bacteriophage Proteins." ]

[ 2017 ]

1

[]

0

null

[ "Bacilli", "Caudoviricetes" ]

[ 26, 4 ]

2

[]

0

true

Family

AcrIIA3

6

IPR061053

61,053

His-Xaa-Ser repeat protein HxsA3

HisXaaSer_A3

Domain

28

false

This entry represents an alternate form of the His-Xaa-Ser repeat protein HxsA, represented by . These proteins, for example contain a conserved N-terminal region, followed by the His-Xaa-Ser repeat region. The C-terminal region is highly variable.

[]

0

[ "NCBIFAM" ]

[ "NF038309" ]

[ "HisXaaSer_A3" ]

[ 28 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 28 ]

1

[]

0

true

Domain

His-Xaa-Ser repeat protein HxsA3

HisXaaSer_A3

6

IPR061054

61,054

SemD/SinC

Family

27

false

This entry represents SemD, SinC and related proteins. CPn0677 (renamed SemD) from the intracellular pathogen Chlamydia pneumoniae is secreted early by the type III secretion system (T3SS). It provides a scaffolding function that recruits other internalisation-promoting effectors [ ]. Its homologue G5Q_0070 (SinC) from...

[]

0

[ "NCBIFAM" ]

[ "NF046087" ]

[ "T3SS_scaff_SemD" ]

[ 27 ]

1

[]

0

[ "8s5r", "8s5t" ]

2

[ "PUB00159820", "PUB00159821" ]

[ "25788290", "37179401" ]

[ "SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors.", "A single chlamydial protein reshapes the plasma membrane and serves as recruiting platform for central endocytic effector proteins." ]

[ 2015, 2023 ]

2

[]

0

null

[ "Chlamydia" ]

[ 27 ]

1

[]

0

true

Family

SemD/SinC

1

IPR061056

61,056

WESB_1763 membrane protein-like

Brachy_memb_1

Family

26

false

Members of this family are highly hydrophobic proteins that appear so far to be restricted to the genus Brachyspira, a spirochete lineage. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF041424" ]

[ "Brachy_memb_1" ]

[ 26 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Brachyspira" ]

[ 26 ]

1

[]

0

true

Family

WESB_1763 membrane protein-like

Brachy_memb_1

9

IPR061057

61,057

Linaridin

Linaridin_RiPP

Family

26

false

Linaridins are ribosomally translated, post-translationally modified peptide natural products, or RiPPs. Examples include cypemycin, SGR-1832, and legonaridin [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033402" ]

[ "linaridin_RiPP" ]

[ 26 ]

1

[]

0

[]

0

[ "PUB00105074" ]

[ "26256511" ]

[ "Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate." ]

[ 2015 ]

1

[]

0

null

[ "Streptomyces" ]

[ 26 ]

1

[]

0

true

Family

Linaridin

Linaridin_RiPP

1

IPR061058

61,058

SAR1012 small protein

SAR1012_fam

Family

25

false

This small protein of unknown function is encoded in multiple species of Staphylococcus. It has been demonstrated by mass spectroscopy to be expressed with an unmodified N-terminal fMet residue [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF040879" ]

[ "SAR1012_fam" ]

[ 25 ]

1

[]

0

[]

0

[ "PUB00105616", "PUB00106012" ]

[ "23554199", "34061833" ]

[ "Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages.", "Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach....

[ 2013, 2021 ]

2

[]

0

null

[ "Staphylococcus" ]

[ 25 ]

1

[]

0

true

Family

SAR1012 small protein

SAR1012_fam

6

IPR061060

61,060

RaxX-like

RaxX_RiPP

Family

24

false

RaxX (Required for Activation of XA21-mediated immunity X), produced by many strains of Xanthomonas, is a RiPP microbial peptide family. Characterised members have a sulfated tyrosine and interact with the rice immune receptor XA21 [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038382" ]

[ "RaxX_RiPP" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00105761" ]

[ "30948631" ]

[ "Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor." ]

[ 2019 ]

1

[]

0

null

[ "Xanthomonas" ]

[ 24 ]

1

[]

0

true

Family

RaxX-like

RaxX_RiPP

6

IPR061061

61,061

Cittilin-like

Cittilin_RiPP

Family

24

false

Cittilins, such as cittilin A from Myxococcus xanthus, are RiPP natural products. Known examples of the peptide precursor end with sequence YXYY. The precursor may be only 27 amino acids long. The mature form contains bicyclic tetrapeptide scaffold with biaryl and aryl-oxygen-aryl ether bonds. The biosynthetic gene clu...

[]

0

[ "NCBIFAM" ]

[ "NF038373" ]

[ "cittilin_RiPP" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00105755", "PUB00105756" ]

[ "32935693", "32639716" ]

[ "New developments in RiPP discovery, enzymology and engineering.", "Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus." ]

[ 2021, 2020 ]

2

[]

0

null

[ "Bacteria" ]

[ 24 ]

1

[]

0

true

Family

Cittilin-like

Cittilin_RiPP

7

IPR061062

61,062

MAG0130/MAG3770-like

MAG0130_MAG3770-like

Family

24

false

Members of this family of uncharacterised hydrophobic proteins include MAG0130 ( ) and MAG3770 ( ) from Mycoplasmopsis agalactiae, and their respective orthologs from Mycoplasmopsis bovis. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF045993" ]

[ "MAG0130_MAG3770" ]

[ 24 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 24 ]

1

[]

0

true

Family

MAG0130/MAG3770-like

MAG0130_MAG3770-like

8

IPR061063

61,063

CRISPR-associated protein Csx27-like

CAS_Csx27

Family

23

false

Csx27 and Csx28 are type VI-B CRISPR accessory proteins that occur together and accompany a minority of type VI-B CRISPR-associated RNA-guided ribonuclease Cas13b proteins [ ].

[]

0

[ "NCBIFAM" ]

[ "NF040557" ]

[ "CAS_Csx27" ]

[ 23 ]

1

[]

0

[]

0

[ "PUB00105831" ]

[ "28065598" ]

[ "Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28." ]

[ 2017 ]

1

[]

0

null

[ "Bacteroidota" ]

[ 23 ]

1

[]

0

true

Family

CRISPR-associated protein Csx27-like

CAS_Csx27

1

IPR061066

61,066

Quorum-sensing system DWW-type pheromone

Pheromon_TrpTrp

Family

23

false

Members of this family are pheromone precursor peptides about 31 amino acids in length, including a signal peptide. The active pheromone is derived from the C-terminal few residues, containing a nearly invariant DWW motif. Member proteins are found encoded near Rgg-type quorum-sensing transcriptional regulators [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038244" ]

[ "pheromon_TrpTrp" ]

[ 23 ]

1

[]

0

[]

0

[ "PUB00105648" ]

[ "20969646" ]

[ "A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator." ]

[ 2010 ]

1

[]

0

null

[ "Streptococcus" ]

[ 23 ]

1

[]

0

true

Family

Quorum-sensing system DWW-type pheromone

Pheromon_TrpTrp

3

IPR061067

61,067

3-thiaglutamate biosynthesis pearlin carrier peptide TglA

TglA_fam_RiPP

Family

23

false

TglA is synthesized on the ribosome, then used repeatedly in a pathway in which 3-thiaglutamate is assembled on, then released from, the C-terminal amino acid. Cys is added by TglB to the C terminus of TglA, then acted on by the multinuclear non-heme iron-dependent oxidative (MNIO) enzyme TglH, with assistance by TglI....

[]

0

[ "NCBIFAM" ]

[ "NF038377" ]

[ "TglA_fam_RiPP" ]

[ 23 ]

1

[]

0

[]

0

[ "PUB00105755", "PUB00105760", "PUB00153337", "PUB00162791" ]

[ "32935693", "31320540", "35362960", "35787182" ]

[ "New developments in RiPP discovery, enzymology and engineering.", "Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products.", "Substrate Recognition by the Peptidyl-(S)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis.", "Biosynthesis of 3-thia-α-amino ...

[ 2021, 2019, 2022, 2022 ]

4

[]

0

null

[ "Pseudomonadota" ]

[ 23 ]

1

[]

0

true

Family

3-thiaglutamate biosynthesis pearlin carrier peptide TglA

TglA_fam_RiPP

6

IPR061069

61,069

Host RNA manipulator TomO, core region

TomO_WD1278_core

Domain

20

false

This entry represents the conserved core region of surface-exposed or secreted protein TomO from the Wolbachia endosymbiont of Drosophila melanogaster and its homologues from other species of Wolbachia. TomO contains also a separately described hydrophobic tail region that it shares with WD_0630 and its orthologues. In...

[]

0

[ "NCBIFAM" ]

[ "NF047985" ]

[ "TomO_WD1278" ]

[ 20 ]

1

[]

0

[]

0

[ "PUB00162895" ]

[ "27498563" ]

[ "Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants." ]

[ 2016 ]

1

[]

0

null

[ "Trichonephila clavata", "Wolbachia" ]

[ 11, 9 ]

2

[]

0

true

Domain

Host RNA manipulator TomO, core region

TomO_WD1278_core

2

IPR061073

61,073

Mbov_0283/Mbov_0339-like surface lipoprotein, C-terminal domain

Mbov0283-like_LP_C

Domain

19

false

This entry describes the C-terminal domain of a number of variable surface lipoproteins in Mycoplasma-like bacterial species. These lipoproteins include paralogues Mbov_0283, Mbov_0339, Mbov_0347, and Mbov_0458 from Mycoplasmopsis bovis.

[]

0

[ "NCBIFAM" ]

[ "NF045982" ]

[ "Mbov0283_fam_LP" ]

[ 19 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Metamycoplasmataceae" ]

[ 19 ]

1

[]

0

true

Domain

Mbov_0283/Mbov_0339-like surface lipoprotein, C-terminal domain

Mbov0283-like_LP_C

7

IPR061076

61,076

Thioviridamide

Thiovirid_RiPP

Family

18

false

Thioviridamide represents one of the rarer known classes of ribosomally translated, post-translationally modified peptide (RiPP) antibiotics [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF033415" ]

[ "thiovirid_RiPP" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00105081", "PUB00105082" ]

[ "23995943", "28981254" ]

[ "Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.", "Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products." ]

[ 2013, 2017 ]

2

[]

0

null

[ "Actinomycetes" ]

[ 18 ]

1

[]

0

true

Family

Thioviridamide

Thiovirid_RiPP

3

IPR061077

61,077

FRAT-87-like

FRAT_87_prot

Family

20

false

FRAT-87 is a rare protein family whose founding members were a Faecalibaculum rodentium Array of Tandem proteins, all six exactly 87 amino acids in length, aligning without gaps, but with pairwise identities as low as 46 percent. Similar sets of paralogues are found in other species such as Ileibacterium valens and All...

[]

0

[ "NCBIFAM" ]

[ "NF045479" ]

[ "FRAT_87_prot" ]

[ 20 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Erysipelotrichaceae" ]

[ 20 ]

1

[]

0

true

Family

FRAT-87-like

FRAT_87_prot

3

IPR061080

61,080

StcA-like

Biofilm_StcA

Family

17

false

StcA (streptococcal charged A protein), as described in Streptococcus pyogenes, is a small, positively charged, secreted protein that participates in a quorum-sensing system, and promotes biofilm formation [ ]. Related proteins are found in several other Streptococcus spp.

[]

0

[ "NCBIFAM" ]

[ "NF033798" ]

[ "biofilm_StcA" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00105334" ]

[ "29555699" ]

[ "A Quorum Sensing-Regulated Protein Binds Cell Wall Components and Enhances Lysozyme Resistance in Streptococcus pyogenes." ]

[ 2018 ]

1

[]

0

null

[ "Streptococcus" ]

[ 17 ]

1

[]

0

true

Family

StcA-like

Biofilm_StcA

7

IPR061081

61,081

Anti-phage DNA glycosylase Brig1

Antiviral_Brig1

Family

17

false

Brig1 is a DNA glycosylase that targets a-glucosylated hmC nucleobases in the viral DNA to provide defense against viral infections. It excises a-glucosyl-hmC nucleobases from ssDNA to generate abasic sites [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047634" ]

[ "antiviral_Brig1" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00159596" ]

[ "38632404" ]

[ "DNA glycosylases provide antiviral defence in prokaryotes." ]

[ 2024 ]

1

[]

0

null

[ "Actinomycetota" ]

[ 17 ]

1

[]

0

true

Family

Anti-phage DNA glycosylase Brig1

Antiviral_Brig1

5

IPR061082

61,082

STAUR_1299-like

STAUR_1299_fam

Family

17

false

Members of this family, including STAUR_1299 from Stigmatella aurantiaca, and related sequences from Myxococcota.

[]

0

[ "NCBIFAM" ]

[ "NF041086" ]

[ "STAUR_1299_fam" ]

[ 17 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Myxococcota" ]

[ 17 ]

1

[]

0

true

Family

STAUR_1299-like

STAUR_1299_fam

3

IPR061083

61,083

ECH_0659-like

ECH_0659_fam

Family

17

false

Proteins of this family are conserved across some Ehrlichia and Wolbachia species. The gene encodes ECH_0659 family protein is tightly linked to several genes encoding phage proteins [ ].

[]

0

[ "NCBIFAM" ]

[ "NF049895" ]

[ "ECH_0659_fam" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00163166" ]

[ "33875547" ]

[ "Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation." ]

[ 2021 ]

1

[]

0

null

[ "Anaplasmataceae", "Glossina austeni" ]

[ 16, 1 ]

2

[]

0

true

Family

ECH_0659-like

ECH_0659_fam

7

IPR061088

61,088

GIVxVP-like

GIVxVP

Family

14

false

GIVxVP is a rare, small, uncharacterised protein found in Cyanobacteria such as Synechococcus lacustris and Cyanobium gracile, in a conserved gene neighbourhood of unknown function. Member sequences are about 70 amino acids in length with two apparent transmembrane segments.

[]

0

[ "NCBIFAM" ]

[ "NF041044" ]

[ "GIVxVP" ]

[ 14 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae" ]

[ 14 ]

1

[]

0

true

Family

GIVxVP-like

GIVxVP

4

IPR061089

61,089

T4SS-associated protein WBM0748

WBM0748_T4SS

Family

14

false

The founding member of this family, WBM0748 from the Wolbachia endosymbiont of Brugia malayi, was observed to be coexpressed with type IV secretion system (T4SS) apparatus proteins, as were several neighbouring proteins. It was therefore suggested to be a T4SS effector, although coexpression without evidence of secreti...

[]

0

[ "NCBIFAM" ]

[ "NF049850" ]

[ "WBM0748_T4SS" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00163175" ]

[ "30261054" ]

[ "Identification of putative effectors of the Type IV secretion system from the Wolbachia endosymbiont of Brugia malayi." ]

[ 2018 ]

1

[]

0

null

[ "Arthropoda", "Wolbachia" ]

[ 5, 9 ]

2

[]

0

true

Family

T4SS-associated protein WBM0748

WBM0748_T4SS

6

IPR061091

61,091

Small protein SR7P

Small_SR7P

Family

15

false

SR7P is a small protein, about 40 amino acids in length, translated from a reading frame in the dual-function antisense RNA SR7 of Bacillus subtilis and many other Bacillus species. SR7P interacts with enolase, which serves as a scaffolding protein in the Bacillus form of the RNA degradosome, and increases the amount o...

[]

0

[ "NCBIFAM" ]

[ "NF047535" ]

[ "small_SR7P" ]

[ 15 ]

1

[]

0

[]

0

[ "PUB00159306", "PUB00159307", "PUB00159308" ]

[ "34066298", "32752915", "37994189" ]

[ "Moonlighting in Bacillus subtilis: The Small Proteins SR1P and SR7P Regulate the Moonlighting Activity of Glyceraldehyde 3-Phosphate Dehydrogenase A (GapA) and Enolase in RNA Degradation.", "SR7 - a dual-function antisense RNA from Bacillus subtilis.", "A comprehensive study of the interactions i...

[ 2021, 2021, 2024 ]

3

[]

0

null

[ "Bacillus" ]

[ 15 ]

1

[]

0

true

Family

Small protein SR7P

Small_SR7P

9

IPR061092

61,092

Recombination system host exonuclease inhibitor

Lp1_17_inhib

Family

14

false

Lp_0640 from Lactobacillus plantarum WCFS1 is defined as protein 17 of prophage Lp1, and as part of a three protein system involved in phage recombination, together with Lp_0641 (a single strand annealing protein) and Lp_0642 (a phage exonuclease). Lp_0640 is theorised to be a phage inhibitor of host exonucleases [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047326" ]

[ "lp1_17_inhib" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00159651" ]

[ "26438232" ]

[ "Prophage recombinases-mediated genome engineering in Lactobacillus plantarum." ]

[ 2015 ]

1

[]

0

null

[ "Lactiplantibacillus" ]

[ 14 ]

1

[]

0

true

Family

Recombination system host exonuclease inhibitor

Lp1_17_inhib

7

IPR061095

61,095

Inclusion membrane protein InaC

InaC_CT813

Family

14

false

InaC (CT813) is described as an inclusion membrane protein for actin assembly. It is found in several intracellular pathogens from the genus Chlamydia. InaC recruits host GTPases, which leads to the formation of microtubules around the inclusion from host cytoskeletal proteins [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF049857" ]

[ "InaC_CT813" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00163119", "PUB00163120" ]

[ "36651786", "28465429" ]

[ "Chlamydia trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion.", "Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning." ]

[ 2023, 2017 ]

2

[]

0

null

[ "Chlamydia" ]

[ 14 ]

1

[]

0

true

Family

Inclusion membrane protein InaC

InaC_CT813

2

IPR061096

61,096

TM0026-like

TM0026_fam

Family

14

false

Proteins of this family are short membrane proteins with only two transmembrane helices [ ]. Their function has not been understood yet.

[]

0

[ "NCBIFAM" ]

[ "NF050182" ]

[ "TM0026_fam" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00162855" ]

[ "23011877" ]

[ "Backbone ¹H, ¹³C and ¹⁵N resonance assignments of the α-helical membrane protein TM0026 from Thermotoga maritima." ]

[ 2013 ]

1

[]

0

null

[ "Thermotogales" ]

[ 14 ]

1

[]

0

true

Family

TM0026-like

TM0026_fam

8

IPR061097

61,097

Type VI secretion system protein PdpE

T6SS_PdpE_Fran

Family

14

false

PdpE is encoded within the type VI secretion system (T6SS) locus in Francisella tularensis and several other members of the genus, is secreted by that system, but has not been shown to be essential to virulence and is therefore not currently named as a T6SS effector protein [ ]. So far, no homologues have been detected...

[]

0

[ "NCBIFAM" ]

[ "NF041242" ]

[ "T6SS_PdpE_Fran" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00106255" ]

[ "23185631" ]

[ "Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection." ]

[ 2012 ]

1

[]

0

null

[ "Francisella" ]

[ 14 ]

1

[]

0

true

Family

Type VI secretion system protein PdpE

T6SS_PdpE_Fran

5

IPR061098

61,098

Porin PorA

PorA_1

Family

13

false

This entry represents Corynebacterial Porin A (PorA) family of porins, which are short membrane proteins.

[]

0

[ "NCBIFAM" ]

[ "NF033925" ]

[ "pora_1" ]

[ 13 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Corynebacterium" ]

[ 13 ]

1

[]

0

true

Family

Porin PorA

PorA_1

4

IPR061099

61,099

Peptide antibiotic dynobactin A

Dynobact_RiPP

Family

13

false

Members of this family are RiPP precursor peptides modified by radical SAM/SPASM enzyme maturases. The founding member of this family, from Photorhabdus australis, has the ten amino amino acids WNSNVHSYRF in the mature product called dynobactin A. This antibiotic targets BamA, involved in the insertion of β-barrel prot...

[]

0

[ "NCBIFAM" ]

[ "NF041295" ]

[ "dynobact_RiPP" ]

[ 13 ]

1

[]

0

[]

0

[ "PUB00106300" ]

[ "36163500" ]

[ "Computational identification of a systemic antibiotic for gram-negative bacteria." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 13 ]

1

[]

0

true

Family

Peptide antibiotic dynobactin A

Dynobact_RiPP

6

IPR061101

61,101

Actinodefensin-associated protein A

Act_def_assoc_A

Family

13

false

Actinodefensin ( ) is a bacterial branch of the arthropod defensin family. Members of that family occur in the Actinomyes lineage, have a distinctive N-terminal region that may reflect how processing and transport occur, and are found in a conserved gene neighbourhood. Actinodefensin-associated protein A is found exclu...

[]

0

[ "NCBIFAM" ]

[ "NF038043" ]

[ "act_def_assoc_A" ]

[ 13 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomyces" ]

[ 13 ]

1

[]

0

true

Family

Actinodefensin-associated protein A

Act_def_assoc_A

5

IPR061102

61,102

Streptosactin precursor

Streptosactin

Family

13

false

Streptosactin is a ribosomally synthesised, post-translationally modified natural product, produced from a typically 35-amino acid precursor. Streptosactin gets its name from being found in Streptococcus, and from being a sactipeptide, means it is cyclised by Sulfur-to-Alpha-Carbon linkages from at least one Cys residu...

[]

0

[ "NCBIFAM" ]

[ "NF050037" ]

[ "streptosactin" ]

[ 13 ]

1

[]

0

[]

0

[ "PUB00162692" ]

[ "32845143" ]

[ "Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome." ]

[ 2020 ]

1

[]

0

null

[ "Lactobacillales" ]

[ 13 ]

1

[]

0

true

Family

Streptosactin precursor

Streptosactin

5

IPR061103

61,103

PGAP-CTERM protein-sorting domain

PGAP-CTERM

Domain

13

false

The PGAP-CTERM protein-sorting signal is recognised and processed by the exosortase XrtZ. This sorting domain is found associated with [ ].

[]

0

[ "NCBIFAM" ]

[ "NF050189" ]

[ "PGAP-CTERM" ]

[ 13 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "PVC group" ]

[ 13 ]

1

[]

0

true

Domain

PGAP-CTERM protein-sorting domain

PGAP-CTERM

9

IPR061104

61,104

Phage anti-silencing protein Mip

Anti_silent_Mip

Family

12

false

Mip (MvaT inhibiting protein) is a countermeasure protein found in lytic phage infecting Pseudomonas aeruginosa and related species. It is an early protein that binds the host xenogeneic silencing protein MvaT and inhibits its DNA-binding activity [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041858" ]

[ "anti_silent_Mip" ]

[ 12 ]

1

[]

0

[ "6yse" ]

1

[ "PUB00159671" ]

[ "26594207" ]

[ "Antibacterial phage ORFans of Pseudomonas aeruginosa phage LUZ24 reveal a novel MvaT inhibiting protein." ]

[ 2015 ]

1

[]

0

null

[ "Viruses" ]

[ 12 ]

1

[]

0

true

Family

Phage anti-silencing protein Mip

Anti_silent_Mip

8

IPR061106

61,106

Major outer membrane protein TSA22

Scrub_typh_TSA22

Family

12

false

Members of this family are TSA22, one of three major outer membrane proteins, the so-called type-specific antigens, in two species of Orientia, including O. tsutsugamushi, causative agent of scrub typhus. The other type-specific antigens are TSA47 (a serine proteins in the DegP/HtrA family) and the much better known TS...

[]

0

[ "NCBIFAM" ]

[ "NF033389" ]

[ "scrub_typh_TSA22" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00105058" ]

[ "22505220" ]

[ "Molecular characterization of three major outer membrane proteins, TSA56, TSA47 and TSA22, in Orientia tsutsugamushi." ]

[ 2012 ]

1

[]

0

null

[ "Orientia" ]

[ 12 ]

1

[]

0

true

Family

Major outer membrane protein TSA22

Scrub_typh_TSA22

6

IPR061107

61,107

Inclusion membrane protein CPSIT_0556-like

IncMemCPSIT0556

Family

12

false

CPSIT_0556 inhibits human polymorphonuclear neutrophil apoptosis [ ].

[]

0

[ "NCBIFAM" ]

[ "NF049906" ]

[ "IncMemCPSIT0556" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00163121" ]

[ "34484191" ]

[ "The Chlamydia psittaci Inclusion Membrane Protein 0556 Inhibits Human Neutrophils Apoptosis Through PI3K/AKT and NF-κB Signaling Pathways." ]

[ 2021 ]

1

[]

0

null

[ "Chlamydia" ]

[ 12 ]

1

[]

0

true

Family

Inclusion membrane protein CPSIT_0556-like

IncMemCPSIT0556

5

IPR061111

61,111

Azolemycin-like, core region

AzmA_fam_RiPP

Domain

10

false

The azolemycin precursor peptide, AzmA, contains a mature (core) peptide region derived from the sequence VVSTCTI. Examining genomic context from that RiPP precursor peptides related to AzmA are much more similar in the leader peptide region than in the core region, and that the proper length for the percursor peptide ...

[]

0

[ "NCBIFAM" ]

[ "NF033434" ]

[ "AzmA_fam_RiPP" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00105101" ]

[ "28791101" ]

[ "Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264." ]

[ 2016 ]

1

[]

0

null

[ "Streptomycetaceae" ]

[ 10 ]

1

[]

0

true

Domain

Azolemycin-like, core region

AzmA_fam_RiPP

1

IPR061112

61,112

GUMAP-like, C-terminal domain

GUMAP_C

Domain

10

false

GUMAP (Giant Ureaplasma Membrane-Anchored Protein) is a very large protein found in several species of the genus Ureaplasma, a lineage that resembles Gram-positive bacteria by ancestry but that lacks a peptidoglycan cell wall. GUMAP proteins average about 5000 amino acids in length. Near the C-terminal, these proteins ...

[]

0

[ "NCBIFAM" ]

[ "NF033897" ]

[ "GUMAP_C" ]

[ 10 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Ureaplasma" ]

[ 10 ]

1

[]

0

true

Domain

GUMAP-like, C-terminal domain

GUMAP_C

7

IPR061114

61,114

Antiviral RADAR system accessory protein RdrD

RdrD

Family

8

false

Proteins of this family are accessory components of the anti-phage system RADAR (restriction by an adenosine deaminase acting on RNA). RADAR mediates RNA editing in response to phage infections [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041745" ]

[ "RdrD" ]

[ 8 ]

1

[]

0

[]

0

[ "PUB00152882" ]

[ "32855333" ]

[ "Diverse enzymatic activities mediate antiviral immunity in prokaryotes." ]

[ 2020 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 8 ]

1

[]

0

true

Family

Antiviral RADAR system accessory protein RdrD

RdrD

6

IPR061116

61,116

Cyanobactin class RiPP

Moor_cyan_RiPP

Family

8

false

Members of this rather narrowly defined family are apparent RiPP (ribosomally synthesized and post-translationally modified peptide natural product) precursors, related in the leader peptide region at least to the family of microcyclamide/patellamide family RiPP precursors. Most members of this family have a PFAGDxxE m...

[]

0

[ "NCBIFAM" ]

[ "NF042906" ]

[ "Moor_cyan_RiPP" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Moorena producens" ]

[ 8 ]

1

[]

0

true

Family

Cyanobactin class RiPP

Moor_cyan_RiPP

7

IPR061119

61,119

Leaderless bacteriocin GatB

GarvicinKS_B

Family

8

false

GatB is one component of the multipeptide leaderless bacteriocin designated garvicin KS, as found in Lactococcus garvieae KS1546 [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038165" ]

[ "garvicinKS_B" ]

[ 8 ]

1

[]

0

[]

0

[ "PUB00105584" ]

[ "27316965" ]

[ "Novel Group of Leaderless Multipeptide Bacteriocins from Gram-Positive Bacteria." ]

[ 2016 ]

1

[]

0

null

[ "Bacilli" ]

[ 8 ]

1

[]

0

true

Family

Leaderless bacteriocin GatB

GarvicinKS_B

6

IPR061121

61,121

Enhanced entry virulence factor RtxA, N-terminal domain

Legion_RtxA_N

Domain

10

false

This entry represents the N-terminal, non-repetitive portion of the Legionella virulence factor RxtA, named for the presence of tandem repeats-in-toxin (RTX) domains. RtxA can be four to six thousand amino acids long. In some isolates, the toxin is divided into two tandem ORFs but presumably re-form by recombination. R...

[]

0

[ "NCBIFAM" ]

[ "NF041514" ]

[ "Legion_RtxA_N" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00151396", "PUB00151397", "PUB00151398" ]

[ "10846213", "31935215", "11119544" ]

[ "Identification of novel loci involved in entry by Legionella pneumophila.", "Whole genome sequence analysis reveals the broad distribution of the RtxA type 1 secretion system and four novel putative type 1 secretion systems throughout the Legionella genus.", "Legionella pneumophila entry gene rtxA is involved ...

[ 2000, 2020, 2001 ]

3

[]

0

null

[ "Legionella pneumophila" ]

[ 10 ]

1

[]

0

true

Domain

Enhanced entry virulence factor RtxA, N-terminal domain

Legion_RtxA_N

3

IPR061125

61,125

Mbov_0389-like

Mbov_0389_HExxH

Family

7

false

The founding member of this family, Mbov_0389 from Mycoplasmopsis bovis, in encoded within the Integrative Conjugal Element ICEB-1 and is presumed to be part of its function [ ]. This family may to be related to the M78 family of zinc metallopeptidases described by , with conservation of the signature HExxH motif.

[]

0

[ "NCBIFAM" ]

[ "NF045880" ]

[ "Mbov_0389_HExxH" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00159434" ]

[ "22693604" ]

[ "Comparative geno-plasticity analysis of Mycoplasma bovis HB0801 (Chinese isolate)." ]

[ 2012 ]

1

[]

0

null

[ "Metamycoplasmataceae" ]

[ 7 ]

1

[]

0

true

Family

Mbov_0389-like

Mbov_0389_HExxH

7

IPR061127

61,127

RP165-like

RP165FamHumup

Family

7

false

This entry represents a small set of uncharacterised proteins from Rickettsia, that is upregulated in human cell lines [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047992" ]

[ "RP165FamHumup" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00163028" ]

[ "28709615" ]

[ "Transcriptional profiling of Rickettsia prowazekii coding and non-coding transcripts during in vitro host-pathogen and vector-pathogen interactions." ]

[ 2017 ]

1

[]

0

null

[ "Rickettsia" ]

[ 7 ]

1

[]

0

true

Family

RP165-like

RP165FamHumup

7

IPR061128

61,128

Putative selenocysteine system protein, Asgard archaea-like

Sel_Asgard

Family

10

false

Members of this family, are part of a conserved gene neighbourhood with other proteins required for selenoprotein biosynthesis, such as O-phosphoseryl-tRNA(Sec) selenium transferase [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045535" ]

[ "Sel_Asgard" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00159279" ]

[ "38896033" ]

[ "Asgard archaeal selenoproteome reveals a roadmap for the archaea-to-eukaryote transition of selenocysteine incorporation machinery." ]

[ 2024 ]

1

[]

0

null

[ "Promethearchaeati", "marine sediment metagenome" ]

[ 3, 7 ]

2

[]

0

true

Family

Putative selenocysteine system protein, Asgard archaea-like

Sel_Asgard

2

IPR061129

61,129

WD_0736-like

WD_0736_fam

Family

6

false

This family, restricted to the Wolbachia-like alphaproteobacterial endosymbionts, appears distantly related to the DUF4293 ( ) family of putative membrane proteins.

[]

0

[ "NCBIFAM" ]

[ "NF049853" ]

[ "WD_0736_fam" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Wolbachia" ]

[ 6 ]

1

[]

0

true

Family

WD_0736-like

WD_0736_fam

1

IPR061130

61,130

YLP-box putative sorting motif

Sort_motif_YLP

Conserved_site

6

false

The very short C-terminal protein sequence region described in this entry, is a putative protein-sorting signal, the YLP-box, whose hypothesised cognate sorting/anchoring partner remains unknown. Proteins ending with this sequence region average over 700 amino acids in length mainly from Chloroflexales and Thermoflexal...

[]

0

[ "NCBIFAM" ]

[ "NF050076" ]

[ "sort_motif_YLP" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chloroflexota" ]

[ 6 ]

1

[]

0

true

Conserved_site

YLP-box putative sorting motif

Sort_motif_YLP

3

IPR061133

61,133

Leaderless bacteriocin LsbB

Enterocin_LsbB

Family

6

false

Members of this family are leaderless peptide components of bacteriocins with a conserved motif KXXXGXXPWE [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033385" ]

[ "enterocin_LsbB" ]

[ 6 ]

1

[]

0

[ "5l82" ]

1

[ "PUB00105055" ]

[ "24993828" ]

[ "Defining the structure and receptor binding domain of the leaderless bacteriocin LsbB." ]

[ 2014 ]

1

[]

0

null

[ "Enterococcus" ]

[ 6 ]

1

[]

0

true

Family

Leaderless bacteriocin LsbB

Enterocin_LsbB

6

IPR061135

61,135

CcmD-like small membrane protein, Wolbachia-type

CcmD-like_Wolb

Family

6

false

Members of this family are small proteins, about 45 amino acids in length, with a strongly hydrophobic N-terminal half, and with considerable sequence similarity to the longer protein CcmD described by ( ). This family occurs in the genus Wolbachia, encoded next to an apparent CcmE protein.

[]

0

[ "NCBIFAM" ]

[ "NF047949" ]

[ "CcmD_like_Wolb" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Anaplasmataceae" ]

[ 6 ]

1

[]

0

true

Family

CcmD-like small membrane protein, Wolbachia-type

CcmD-like_Wolb

4

IPR061139

61,139

Actinobacterial multiple cyclophane triceptide AmcA, group 4

Phane_AmcA_4

Family

5

false

Members of this family belong to one of several classes of peptide natural product synthesised on the ribosome and then post-translationally modified (RiPP), where the modification begins with the actinobacterial multiple cyclophane-forming radical SAM peptide maturase AmcB ( ) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041724" ]

[ "phane_AmcA_4" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00152924" ]

[ "36454686" ]

[ "A Prevalent Group of Actinobacterial Radical SAM/SPASM Maturases Involved in Triceptide Biosynthesis." ]

[ 2022 ]

1

[]

0

null

[ "Pseudonocardiaceae" ]

[ 5 ]

1

[]

0

true

Family

Actinobacterial multiple cyclophane triceptide AmcA, group 4

Phane_AmcA_4

8

IPR061140

61,140

Gliding motility internal complex protein MMOB4860-like

Glide_MMOB4860

Family

5

false

This highly divergent protein family is most conserved near its C terminus. It is unusual among subunits of the gliding motility machinery internal complex in not resembling a subunit of F-type ATPase/synthases [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045865" ]

[ "glide_MMOB4860" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00159783" ]

[ "32123220" ]

[ "Identification and sequence analyses of the gliding machinery proteins from Mycoplasma mobile." ]

[ 2020 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 5 ]

1

[]

0

true

Family

Gliding motility internal complex protein MMOB4860-like

Glide_MMOB4860

1

IPR061143

61,143

Ranthipeptide freyrasin-like

Freyrasin-like

Family

5

false

A ranthipeptide is a ribosomally synthesised and post-translationally modified peptide (RiPP) whose linkages from cysteine sulfur atoms are to something besides the alpha carbons of other amino acids. Thus, ranthipeptides differ from sactipeptides (sulfur-to-alpha carbon RiPP peptides). The founding member of this fami...

[]

0

[ "NCBIFAM" ]

[ "NF037957" ]

[ "freyrasin_like" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00105481", "PUB00105482", "PUB00159537" ]

[ "31059252", "31449382", "37460016" ]

[ "Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.", "Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in...

[ 2019, 2019, 2023 ]

3

[]

0

null

[ "Bacteria" ]

[ 5 ]

1

[]

0

true

Family

Ranthipeptide freyrasin-like

Freyrasin-like

1

IPR061144

61,144

Lasso peptide

Rhodolasso

Family

5

false

Members of this family are lasso peptides as found in the genus Rhodothermus. The leader peptide region shows sequence relatedness to several other groups of lasso peptide precursors. Known members of this family have a pair of Cys residues in the core peptide region, suggesting a bicyclic product, with one cross-link ...

[]

0

[ "NCBIFAM" ]

[ "NF033534" ]

[ "rhodolasso" ]

[ 5 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhodothermus" ]

[ 5 ]

1

[]

0

true

Family

Lasso peptide

Rhodolasso

1

IPR061149

61,149

3-thiahomoleucine biosynthesis pearlin carrier peptide TmoA

Carrier_TmoA

Family

4

false

The RiPP-like peptide TmoA is used in Tistrella mobilis as a carrier peptide for the biosynthesis of 3-thiahomoleucine. Like its homologue TglA, used in 3-thiaglutamate biosynthesis, it is modified by amino acid addition at the C-terminal, processed through additional steps by several proteins related to RiPP biosynthe...

[]

0

[ "NCBIFAM" ]

[ "NF050126" ]

[ "carrier_TmoA" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00162791" ]

[ "35787182" ]

[ "Biosynthesis of 3-thia-α-amino acids on a carrier peptide." ]

[ 2022 ]

1

[]

0

null

[ "Tistrella" ]

[ 4 ]

1

[]

0

true

Family

3-thiahomoleucine biosynthesis pearlin carrier peptide TmoA

Carrier_TmoA

7

IPR061150

61,150

T4SS-associated protein EirA

T4SS_assoc_EirA

Family

4

false

EirA (essential for intracellular replication A) was characterised in Coxiella burnetii as critical for replication in host vacuoles [ ]. Its absence appears to block secretion by the Dot/Icm type IV secretion system (T4SS), and family members occur strictly in species with T4SS.

[]

0

[ "NCBIFAM" ]

[ "NF038254" ]

[ "T4SS_assoc_EirA" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00105669" ]

[ "32205404" ]

[ "EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii." ]

[ 2020 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 4 ]

1

[]

0

true

Family

T4SS-associated protein EirA

T4SS_assoc_EirA

5

IPR061151

61,151

YM-216391-like

YM-216391_RiPP

Family

4

false

YM-216391 represents one of the rarer known classes of ribosomally translated, post-translationally modified peptide (RiPP) antibiotics [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033416" ]

[ "YM-216391_RiPP" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00105083" ]

[ "22248379" ]

[ "Analysis of YM-216391 biosynthetic gene cluster and improvement of the cyclopeptide production in a heterologous host." ]

[ 2012 ]

1

[]

0

null

[ "Streptomyces" ]

[ 4 ]

1

[]

0

true

Family

YM-216391-like

YM-216391_RiPP

1

IPR061154

61,154

Linaridin-like RiPP

Linaridin-rel

Family

3

false

Members of this family share N-terminal (leader peptide) sequence with the linaridin family of ribosomally translated, post-translationally modified natural product precursors.

[]

0

[ "NCBIFAM" ]

[ "NF033403" ]

[ "linaridin_rel" ]

[ 3 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 3 ]

1

[]

0

true

Family

Linaridin-like RiPP

Linaridin-rel

9

IPR061155

61,155

Osc7112_2153-like

Osc7112_2153fam

Family

3

false

This rare, small cyanobacterial protein, about 80 amino acids in length, has a signal peptide and a pair of invariant Cys residues that suggest disulfide bond formation. The protein regularly is found encoded just a few genes away from exosortase O (XrtO), but the significance of that finding is unclear.

[]

0

[ "NCBIFAM" ]

[ "NF040661" ]

[ "Osc7112_2153fam" ]

[ 3 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Oscillatoriales" ]

[ 3 ]

1

[]

0

true

Family

Osc7112_2153-like

Osc7112_2153fam

8

IPR061160

61,160

Phazolicin TOMM bacteriocin

Phazolicin_TOMM

Family

2

false

Phazolicin is a ribosome-targeting thiazole/oxazole-modified microcin (TOMM), also called a linear azol(in)e-containing peptides (LAP) [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF038168" ]

[ "phazolicin_TOMM" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00105586", "PUB00105587" ]

[ "31594941", "32296456" ]

[ "Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition.", "Translation-Targeting RiPPs and Where to Find Them." ]

[ 2019, 2020 ]

2

[]

0

null

[ "Hyphomicrobiales" ]

[ 2 ]

1

[]

0

true

Family

Phazolicin TOMM bacteriocin

Phazolicin_TOMM

6

IPR061161

61,161

Peptide pheromone inhibitor Ipd

Pheromone_ipd

Family

2

false

The pheromone inhibitor iPD1, in mature form, is the last 8 amino acids of the product of the ipd gene. It was described in conjugative plasmids of Enterococcus faecalis [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033893" ]

[ "pheromone_ipd" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00035675" ]

[ "7559344" ]

[ "Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes." ]

[ 1995 ]

1

[]

0

null

[ "Enterococcus faecalis" ]

[ 2 ]

1

[]

0

true

Family

Peptide pheromone inhibitor Ipd

Pheromone_ipd

3

IPR061163

61,163

Bactofencin A

Bactofencin_A

Family

2

false

Bactofencin A (BnfA), a class IId bacteriocin from Lactobacillus salivarius, is a disulfide bond-containing 22-amino-acid defensin-like peptide with a broad spectrum of activity. Precursor forms for BnfA and other members of the family average about 49 amino acids in length, with the core peptide starting immediately a...

[]

0

[ "NCBIFAM" ]

[ "NF038163" ]

[ "bactofencin_A" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00105581", "PUB00105582", "PUB00105583" ]

[ "24169573", "30087409", "30540905" ]

[ "Bactofencin A, a new type of cationic bacteriocin with unusual immunity.", "The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation.", "Structure-Activity Relationships of the Bacteriocin Bactofenci...

[ 2013, 2018, 2019 ]

3

[]

0

null

[ "Ligilactobacillus salivarius" ]

[ 2 ]

1

[]

0

true

Family

Bactofencin A

Bactofencin_A

7

IPR061166

61,166

Cys-rich RiPP peptide TM1316

RiPP_TM1316

Family

2

false

Members of this family include the small, Cys-rich peptide TM1316 of Thermotoga maritima ( ), encoded near the peptide-modifying radical SAM/SPASM protein TM1317 ( ). TM1316 is expressed at very high levels in stationary phase.

[]

0

[ "NCBIFAM" ]

[ "NF033413" ]

[ "RiPP_TM1316" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00105078" ]

[ "23974142" ]

[ "Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima." ]

[ 2013 ]

1

[]

0

null

[ "Thermotoga" ]

[ 2 ]

1

[]

0

true

Family

Cys-rich RiPP peptide TM1316

RiPP_TM1316

1

IPR061176

61,176

Rv1157c-like, C-terminal domain

Rv1157c-like_C

Domain

862

false

This entry represents the conserved C-terminal region of surface-exposed actinobacterial member proteins such as NFA_47630 from Nocardia farcinica ( , [ ]) and ML1506 from Mycobacterium leprae ( , [ ]), both tested or discussed as vaccine candidates, and Rv1157c from Mycobacterium tuberculosis ( , [ ]), which was shown...

[]

0

[ "NCBIFAM" ]

[ "NF050168" ]

[ "Rv1157c_Cterm" ]

[ 862 ]

1

[]

0

[]

0

[ "PUB00162844", "PUB00162845", "PUB00162846" ]

[ "33889182", "32443484", "39402651" ]

[ "Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against Mycobacterium leprae and Mycobacterium lepromatosis.", "Potential Plasticity of the Mannoprotein Repertoire Associated to Mycobacterium tuberculosis Virulence Unveiled by Mass Spectrometry-Bas...

[ 2021, 2020, 2024 ]

3

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 861, 1 ]

2

[]

0

true

Domain

Rv1157c-like, C-terminal domain

Rv1157c-like_C

7

IPR061177

61,177

SMc00767-like

Family

551

false

Proteins of this family are found in alphaproteobacteria, including SMc00767 from Sinorhizobium meliloti( ). Mutations in the gene codifying for this protein have been reported to affect acetate utilisation. Complementation experiments showed that SMc00767 restored S.meliloti on growth on acetate. SMc00767 and aceA, wh...

[]

0

[ "NCBIFAM" ]

[ "NF050174" ]

[ "SMc00767_fam" ]

[ 551 ]

1

[]

0

[]

0

[ "PUB00162624" ]

[ "17526694" ]

[ "Functional characterization of the Sinorhizobium meliloti acetate metabolism genes aceA, SMc00767, and glcB." ]

[ 2007 ]

1

[]

0

null

[ "Alphaproteobacteria", "Panagrolaimus superbus", "ecological metagenomes" ]

[ 548, 1, 2 ]

3

[]

0

true

Family

SMc00767-like

8

IPR061178

61,178

ISAon1-like transposase, N-terminal region

ISAon1-like_N

Domain

1,246

false

ISAon1 is a variant form of ISL3 family transposase that lacks the two CXXC motifs in the N-terminal region found in typical ISL3 family transposases. ISAon1 family transposases are proposed to require a +1 frameshift to produce the functional form of the transposase, about 440 amino acids in length. This entry represe...

[]

0

[ "NCBIFAM" ]

[ "NF049916" ]

[ "ISAon1_upstream" ]

[ 1246 ]

1

[]

0

[]

0

[ "PUB00105183" ]

[ "22367867" ]

[ "Exploring bacterial insertion sequences with ISfinder: objectives, uses, and future developments." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 1205, 3, 38 ]

3

[]

0

true

Domain

ISAon1-like transposase, N-terminal region

ISAon1-like_N

7