LiteFold/InterPro · Datasets at Hugging Face

IPR060748

60,748

Uncharacterised conserved protein UCP018868, prokaryotic

UCP018868_prok

Family

47

false

This entry represents uncharacterised proteins found in bacteria and archaea. These proteins contain a P-loop NTPase fold .

[]

0

[ "PFAM" ]

[ "PF27713" ]

[ "UCP018868" ]

[ 47 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR016737" ]

0

1

0

[ "Bacillaceae", "Thermococcaceae" ]

[ 2, 45 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP018868, prokaryotic

UCP018868_prok

5

IPR060749

60,749

Uncharacterized protein AF_2401

AF_2401

Family

62

false

This entry represents Uncharacterized proteins AF_2401 found mostly in archaea and a few bacterial proteins. These proteins are predicted multi-pass membrane proteins.

[]

0

[ "PFAM" ]

[ "PF27715" ]

[ "UCP019236" ]

[ 62 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Acetivibrio", "Archaea" ]

[ 5, 57 ]

2

[]

0

true

Family

Uncharacterized protein AF_2401

AF_2401

6

IPR060750

60,750

Tri6-like, C2H2 zinc finger domain

Znf_C2H2_Tri6-like

Domain

677

false

This entry represents a domain covering the three zinc-finger C2H2 domains in Tri6 and HepR found in fungi. Tri6 is part of the core trichothecene biosynthesis cluster [ , , , ]. It is a zinc finger DNA-binding protein that functions as a pathway-specific transcription factor and positively regulates the other Tri gene...

[]

0

[ "PFAM" ]

[ "PF27716" ]

[ "Tscrpt_reg_Tri6" ]

[ 677 ]

1

[]

0

[]

0

[ "PUB00017111", "PUB00087313", "PUB00087314", "PUB00087315", "PUB00087316", "PUB00162556" ]

[ "11352533", "7646028", "16347944", "12732543", "10361036", "30466366" ]

[ "A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum.", "Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides.", "Regulation of Trichodiene Synthase in Fusarium sporotri...

[ 2001, 1995, 1989, 2003, 1999, 2019 ]

6

[ "IPR013087" ]

[]

1

0

1

[ "Pezizomycotina" ]

[ 677 ]

1

[]

0

true

Domain

Tri6-like, C2H2 zinc finger domain

Znf_C2H2_Tri6-like

5

IPR060752

60,752

Membrane protein YqfB

YqfB

Family

1,034

false

This entry represents Membrane protein YqfB found in Bacillus subtilis. This protein is predicted to be localised in the membrane and to act as a single-pass membrane protein. This protein has no effects on FloA or FloT membrane rafts [ ].

[]

0

[ "PFAM" ]

[ "PF27722" ]

[ "YqfB" ]

[ 1034 ]

1

[]

0

[]

0

[ "PUB00104908" ]

[ "22753055" ]

[ "Synthetic motility and cell shape defects associated with deletions of flotillin/reggie paralogs in Bacillus subtilis and interplay of these proteins with NfeD proteins." ]

[ 2012 ]

1

[]

[ "IPR016788" ]

0

1

0

[ "Bacteria", "Caenorhabditis nigoni", "Pithovirus LCPAC102", "ecological metagenomes" ]

[ 1027, 1, 1, 5 ]

4

[]

0

true

Family

Membrane protein YqfB

YqfB

4

IPR060753

60,753

Uncharacterised conserved protein UCP022260

UCP022260

Family

3,134

false

This entry represents uncharacterised proteins mostly found in plants. These proteins contain helices and disordered regions.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF27723", "PTHR33356" ]

[ "UCP022260", "" ]

[ 2909, 3062 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3134 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 9, 24 ]

3

true

Family

Uncharacterised conserved protein UCP022260

UCP022260

9

IPR060756

60,756

Putative competence-induced protein Ccs4

Ccs4

Family

729

false

These proteins are part of a set in lactobacilalles, including Streptococcus pneumoniae, that undergo late induction by competence pheromone [ ]. This protein shows structural similarity to ArnT from Cupriavidus metallidurans. This protein is an integral membrane lipid-to-lipid glycosyltransferase 4-amino-4-deoxy-L-ara...

[]

0

[ "PFAM" ]

[ "PF27757" ]

[ "Competence-induced_Ccs4" ]

[ 729 ]

1

[]

0

[]

0

[ "PUB00035949", "PUB00052316" ]

[ "14763980", "8901420" ]

[ "Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays.", "Who's competent and when: regulation of natural genetic competence in bacteria." ]

[ 2004, 1996 ]

2

[]

[ "IPR016978" ]

0

1

0

[ "Bacteria", "Methanofollis liminatans DSM 4140", "Spraguea lophii (strain 42_110)", "human gut metagenome" ]

[ 726, 1, 1, 1 ]

4

[]

0

true

Family

Putative competence-induced protein Ccs4

Ccs4

2

IPR060757

60,757

UCP032817-like

Family

3,333

false

This group of uncharacterised proteins are predominantly found in bacteria. The protein shows structural similarity to viral proteins suggesting it may be of prophage origin. This family appears related to .

[]

0

[ "PFAM" ]

[ "PF27765" ]

[ "UCP032817-like" ]

[ 3333 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017008" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 8, 3143, 159, 4, 19 ]

5

[]

0

true

Family

UCP032817-like

7

IPR060758

60,758

UCP032899-like

Family

235

false

Members of this family are surface lipoproteins from Mycoplasmatota bacteria with a plasma membrane but no outer membrane and no cell wall. Members are probably associated with ABC transporter permease and ATPase subunit, and assigned a role in oligopeptide import, but might have additional functions such as cytoadhesi...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045850", "PF27766" ]

[ "ABC_Mplas_LP", "UCP032899" ]

[ 231, 232 ]

2

[]

0

[]

0

[ "PUB00159778", "PUB00159779" ]

[ "25528211", "10438757" ]

[ "The identification of oppA gene homologues as part of the oligopeptide transport system in mycoplasmas.", "The adherence-associated lipoprotein P100, encoded by an opp operon structure, functions as the oligopeptide-binding domain OppA of a putative oligopeptide transport system in Mycoplasma hominis." ]

[ 2015, 1999 ]

2

[]

[ "IPR017012" ]

0

1

0

[ "Bacteria", "Didymodactylos carnosus" ]

[ 234, 1 ]

2

[]

0

true

Family

UCP032899-like

9

IPR060759

60,759

UCP033725-like

Family

1,044

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members of this entry are mainly found in actinoobacteria and firmicutes.

[]

0

[ "PFAM" ]

[ "PF27768" ]

[ "UCP033725" ]

[ 1044 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017020" ]

0

1

0

[ "Bacteria" ]

[ 1044 ]

1

[]

0

true

Family

UCP033725-like

3

IPR060760

60,760

RNA editing complex, structural subunit MP81-like

MP81-like

Family

189

false

This entry represents a group of proteins from Trypanosomatida, including structural subunit MP81 (also known as KREPA1, ) from the RNA editing complex. The editing process is performed by the editosome, a multi-protein complex that catalyses the insertion and deletion of uridylates (U) that occurs during RNA editing. ...

[ "GO:0016556" ]

[ "mRNA modification" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF27771" ]

[ "MP81" ]

[ 189 ]

1

[]

0

[ "3k7u", "3k80", "3k81", "3stb", "4dk3", "4dk6", "4dka", "4dni" ]

8

[ "PUB00042707", "PUB00061432", "PUB00157869" ]

[ "12649499", "20969962", "11564867" ]

[ "Identification of novel components of Trypanosoma brucei editosomes.", "Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.", "Four related proteins of the Trypanosoma brucei RNA editing complex." ]

[ 2003, 2011, 2001 ]

3

[]

[ "IPR017083", "IPR017084", "IPR017085" ]

0

3

0

[ "Eukaryota" ]

[ 189 ]

1

[]

0

true

Family

RNA editing complex, structural subunit MP81-like

MP81-like

3

IPR060761

60,761

Mitochondrial translation factor Atp22

Atp22

Family

73

false

This entry represents the mitochondrial translation factor Atp22, which is specific for subunit 6 of the mitochondrial ATPase [ , ]. Atp22 is a component of the mitochondrial inner membrane required for the expression of the CF(0) component of the ATPase [ ]. Members of this entry are found in ascomycetes.

[ "GO:0045182" ]

[ "translation regulator activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF27772" ]

[ "Atp22" ]

[ 73 ]

1

[]

0

[]

0

[ "PUB00044703", "PUB00044704" ]

[ "12646576", "17110482" ]

[ "ATP22, a nuclear gene required for expression of the F0 sector of mitochondrial ATPase in Saccharomyces cerevisiae.", "The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6-specific translation factor." ]

[ 2003, 2007 ]

2

[]

[ "IPR017207" ]

0

1

0

[ "Saccharomycotina" ]

[ 73 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial translation factor Atp22

Atp22

1

IPR060762

60,762

Putative spore germination protein GerPD

GerPD

Family

871

false

This entry represents a predicted spore germination protein GerPD. They are required for the formation of functionally normal spores. They could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [ ]. Members are mainly found in B...

[ "GO:0009847" ]

[ "spore germination" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF27777" ]

[ "Spore_germination_GerPD" ]

[ 871 ]

1

[]

0

[]

0

[ "PUB00044278" ]

[ "10715007" ]

[ "Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores." ]

[ 2000 ]

1

[]

[ "IPR017257" ]

0

1

0

[ "Bacillales" ]

[ 871 ]

1

[]

0

true

Family

Putative spore germination protein GerPD

GerPD

8

IPR060763

60,763

Conserved hypothetical protein CHP03076-like

CHP03076-like

Family

50

false

The H protein (GcvH) of the glycine cleavage system shuttles the methylamine group of glycine from the P protein to the T protein. Most Chlamydia lack the P and T proteins, and have a single homologue of GcvH that appears deeply split from canonical GcvH in molecular phylogenetic trees. The proteins in this entry are o...

[]

0

[ "PFAM" ]

[ "PF27779" ]

[ "CHP03076_Gly-cleavage" ]

[ 50 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017513" ]

0

1

0

[ "Bacteria", "marine sediment metagenome" ]

[ 49, 1 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP03076-like

CHP03076-like

8

IPR060765

60,765

Conserved hypothetical integral membrane protein

CHIM_prot

Family

1,158

false

This entry includes a small clade that correlates (by both gene clustering and phyletic pattern) to the three gene system. found in several Gram-positive bacteria, where (XrtG) is distantly related to exosortases. Both this narrow clade, and the larger set of full-length homologous integral membrane proteins, have an e...

[]

0

[ "PFAM" ]

[ "PF27792" ]

[ "CHIM_prot" ]

[ 1158 ]

1

[]

0

[]

0

[ "PUB00060405" ]

[ "22037399" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2012 ]

1

[]

[ "IPR021200" ]

0

1

0

[ "Bacillati", "metagenomes" ]

[ 1154, 4 ]

2

[]

0

true

Family

Conserved hypothetical integral membrane protein

CHIM_prot

4

IPR060766

60,766

DNA sulphur modification system-associated protein 4-like

DNA_S_mod_dnd_assoc_4-like

Family

586

false

A DNA sulphur modification system, dnd (degradation during electrophoresis), is sparsely and sporadically distributed among the prokaryotes. Members of this protein family are found close to the dnd operon.

[]

0

[ "PFAM" ]

[ "PF27807" ]

[ "DNA_S_mod_dnd_assoc_4" ]

[ 586 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR023983" ]

0

1

0

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 53, 527, 6 ]

3

[]

0

true

Family

DNA sulphur modification system-associated protein 4-like

DNA_S_mod_dnd_assoc_4-like

4

IPR060767

60,767

Cytochrome c lysine N-methyltransferase 1-like

Ctm1-like

Family

240

false

This family includes Cytochrome c lysine N-methyltransferase 1 from Saccharomyces cerevisiae (Cmt1) and similar proteins from ascomycetes. Ctm1 is a methyltransferase which mediates trimethylation of 'Lys-78' of cytochrome c (CYC1) in budding yeasts [ ].

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF27829" ]

[ "Ctm1" ]

[ 240 ]

1

[ "EC" ]

[ "2.1.1.59" ]

[ "EC:2.1.1.59" ]

1

[]

0

[ "PUB00058134" ]

[ "10791961" ]

[ "Cytochrome c methyltransferase, Ctm1p, of yeast." ]

[ 2000 ]

1

[]

[ "IPR025815" ]

0

1

0

[ "Eukaryota" ]

[ 240 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Cytochrome c lysine N-methyltransferase 1-like

Ctm1-like

6

IPR060768

60,768

IBD2-like

Family

191

false

During mitosis, genomic integrity is maintained by the proper coordination of mitotic events through the spindle checkpoint. The bifurcated spindle checkpoint blocks cell-cycle progression at metaphase by monitoring unattached kinetochores, and inhibits mitotic exit in response to the incorrect orientation of the mitot...

[ "GO:0007094" ]

[ "mitotic spindle assembly checkpoint signaling" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF27834" ]

[ "IBD2" ]

[ 191 ]

1

[]

0

[]

0

[ "PUB00053335", "PUB00060305" ]

[ "18559951", "12072457" ]

[ "Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.", "IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae." ]

[ 2008, 2002 ]

2

[]

[ "IPR026231" ]

0

1

0

[ "Eukaryota" ]

[ 191 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

IBD2-like

7

IPR060769

60,769

EIF3B-like, beta-propeller domain superfamily

EIF3B-like_beta-prop_sf

Homologous_superfamily

37,475

false

This superfamily includes the β-propeller domain found in human Eukaryotic translation initiation factor 3 subunit B (EIF3B), worm Intraflagellar transport protein osm-1, yeast Elongator complex protein 1 (IKI3), bacterial Dipeptidyl-peptidase 5 and similar proteins mainly found in eukaryotes and bacteria. EIF3B is an ...

[]

0

[ "SSF" ]

[ "SSF69322" ]

[ "" ]

[ 37475 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-CEL-5620924", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-5610787", "R-DRE-5610787", "R-HSA-156827", "R-HSA-3214847", "R-HSA-5610787", "R-HSA-5620924", "R-HSA-72649", "R-HSA-72689...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-CEL-5620924", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72695", "REACTOME:R-DDI-72702", "REACTOME:R-DME-5610787", "REACTOME:R-DRE-5610787"...

44

[ "1k32", "1n6d", "1n6e", "1n6f", "4h5i", "4h5j", "4i0o", "4r5o", "5wlc", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6qk7", "6x90", "6ybt", "6zmw", "6zon", "6zp4", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zvj", "7a09", "7ajt", "7aju"...

73

[ "PUB00043578", "PUB00056124", "PUB00090877", "PUB00099501", "PUB00100230", "PUB00109223", "PUB00146055", "PUB00155621" ]

[ "15769872", "17581632", "28479320", "25569479", "31309145", "18755837", "25849773", "27462815" ]

[ "An early step in wobble uridine tRNA modification requires the Elongator complex.", "Reconstitution reveals the functional core of mammalian eIF3.", "Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia.", "Phosphorylation of Elp1 by Hrr25 is required for elongator-depen...

[ 2005, 2007, 2017, 2015, 2019, 2008, 2015, 2016 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 259, 10758, 26222, 120, 116 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 10, 75, 16, 48, 22, 4, 27, 40, 4, 1, 103 ]

12

true

Homologous_superfamily

EIF3B-like, beta-propeller domain superfamily

EIF3B-like_beta-prop_sf

8

IPR060770

60,770

MNIO-type RiPP peptide maturase HvfB-like

HvfB-like

Family

1,617

false

This entry represents the HvfB family of MNIO-type RiPP peptide maturases, which are post-translational modification enzymes involved in the biosynthesis of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products, including from Histophilus somni ( ) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF003818" ]

[ "PRK05409.1" ]

[ 1617 ]

1

[]

0

[ "3bww" ]

1

[ "PUB00161749", "PUB00161768", "PUB00161769" ]

[ "39602266", "31427451", "38968106" ]

[ "A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress.", "Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion.", "A multi-iron enzyme installs copper-binding oxazolone/thioamide pairs on a nont...

[ 2024, 2019, 2024 ]

3

[ "IPR007801" ]

[]

1

0

1

[ "Bacteria", "Podocopida", "ecological metagenomes" ]

[ 1599, 2, 16 ]

3

[]

0

true

Family

MNIO-type RiPP peptide maturase HvfB-like

HvfB-like

1

IPR060771

60,771

LEM-3, GIY-YIG domain, metazoa

GIY-YIG_LEM-3_Metazoa

Domain

1,206

false

This domain is found at the C-terminal of ANKL1/LEM-3 from human and its homologues from metazoa. Ankyrin repeat and LEM domain-containing protein 1 (ANKL1, also known as LEM-domain containing protein 3) is an endonuclease that probably plays a role in the DNA damage response and DNA repair [ , ]. LEM-3 processes chrom...

[]

0

[ "CDD" ]

[ "cd10454" ]

[ "GIY-YIG_COG3680_Meta" ]

[ 1206 ]

1

[]

0

[]

0

[ "PUB00044989", "PUB00084814", "PUB00084815", "PUB00154034" ]

[ "16646971", "22399800", "27245214", "29463814" ]

[ "Phylogenomic analysis of the GIY-YIG nuclease superfamily.", "The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo.", "Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nucle...

[ 2006, 2012, 2016, 2018 ]

4

[ "IPR054739" ]

[]

1

0

1

[ "Metazoa" ]

[ 1206 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 3, 5, 1, 3 ]

6

true

Domain

LEM-3, GIY-YIG domain, metazoa

GIY-YIG_LEM-3_Metazoa

5

IPR060772

60,772

LEM-3-like, GIY-YIG domain, bacteria

GIY-YIG_LEM-3-like_bacteria

Domain

921

false

This entry represents the GIY-YIG domain of a group of functionally uncharacterised proteins from bacteria that are homologues of eukaryotic LEM-3 proteins. These proteins might have nuclease activities and possibly be engaged in DNA repair or recombination, since they share sequence homology with the catalytic GIY-YIG...

[]

0

[ "CDD" ]

[ "cd10440" ]

[ "GIY-YIG_COG3680" ]

[ 921 ]

1

[]

0

[]

0

[ "PUB00044989" ]

[ "16646971" ]

[ "Phylogenomic analysis of the GIY-YIG nuclease superfamily." ]

[ 2006 ]

1

[ "IPR054739" ]

[]

1

0

1

[ "Bacteria", "Caudoviricetes", "Methanobrevibacter gottschalkii", "Steinernema glaseri", "metagenomes" ]

[ 879, 23, 1, 1, 17 ]

5

[]

0

true

Domain

LEM-3-like, GIY-YIG domain, bacteria

GIY-YIG_LEM-3-like_bacteria

6

IPR060778

60,778

CT392

Family

30

false

This strictly chlamydial protein family of about 400 amino acids is named for founding member CT_392 from Chlamydia trachomatis D/UW-3/CX.

[]

0

[ "NCBIFAM" ]

[ "NF047362" ]

[ "CT392_fam" ]

[ 30 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 30 ]

1

[]

0

true

Family

CT392

1

IPR060779

60,779

RiPP cyclopeptide precursor peptide region

RiPP

Conserved_site

13

false

This entry represents the C-terminal precursor peptide region of fungal borosin biosynthetic proteins. Members of this family contain an N-terminal S-adenosylmethionine (SAM)-dependent α-N-methyltransferase domain . The methyltransferase domain iteratively methylates the backbone amide nitrogens of this precursor pepti...

[]

0

[ "NCBIFAM" ]

[ "NF038374" ]

[ "omphalotin_tail" ]

[ 13 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[ "5n0n", "5n0o", "5n0p", "5n0q", "5n0r", "5n0s", "5n0t", "5n0u", "5n0v", "5n0w", "5n0x", "5n4i", "5ouf", "6gew", "6mjg", "6qzy", "6qzz", "6r00", "6tsc" ]

19

[ "PUB00105755", "PUB00105757", "PUB00108414", "PUB00163210" ]

[ "32935693", "28715095", "30204409", "35297605" ]

[ "New developments in RiPP discovery, enzymology and engineering.", "A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin.", "Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.", "Diverse Protein Architectures and α-N</i...

[ 2021, 2017, 2018, 2022 ]

4

[]

0

null

[ "Agaricales" ]

[ 13 ]

1

[]

0

true

Conserved_site

RiPP cyclopeptide precursor peptide region

RiPP

1

IPR060780

60,780

ESX-1 associated ATP-binding protein EpsI, conserved site

EpsI_CS

Conserved_site

127

false

This entry represents a short homology region that is located before the proline-rich region at the N-terminal in EpsI proteins. In Mycobacterium tuberculosis, the ATP-binding protein EpsI is found associated with the ESX-1, a type VII secretion system (T7SS), and regulates that system in response to ATP levels. EpsI-l...

[]

0

[ "NCBIFAM" ]

[ "NF047907" ]

[ "EpsI_Nterm" ]

[ 127 ]

1

[]

0

[]

0

[ "PUB00162816", "PUB00162817" ]

[ "25039394", "27017992" ]

[ "EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis.", "Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis." ]

[ 2014, 2016 ]

2

[]

0

null

[ "Mycobacteriaceae" ]

[ 127 ]

1

[]

0

true

Conserved_site

ESX-1 associated ATP-binding protein EpsI, conserved site

EpsI_CS

4

IPR060782

60,782

Toxic protein TimP

TimP-like

Family

27

false

This entry represents the Toxic protein TimP from Salmonella typhimurium and related proteins. The gene timP (toxic inner membrane protein) occurs within the small structural RNA ryfA. TimP is the toxic component of a probable type I toxin-antitoxin (TA) system. It is neutralised by sRNA antitoxin TimR which binds to t...

[]

0

[ "NCBIFAM" ]

[ "NF040796" ]

[ "toxic_TimP" ]

[ 27 ]

1

[]

0

[]

0

[ "PUB00105969", "PUB00105970" ]

[ "33172998", "34043736" ]

[ "The Small Toxic Salmonella Protein TimP Targets the Cytoplasmic Membrane and Is Repressed by the Small RNA TimR.", "The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli." ]

[ 2020, 2021 ]

2

[]

0

null

[ "Enterobacteriaceae" ]

[ 27 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Toxic protein TimP

TimP-like

8

IPR060786

60,786

Magnetosome protein MamL, Rhodospirillales

MamL_Rhodospirillales

Family

10

false

Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environments. Proteins of this family are involved in magnetite crystal maturation [ ].

[]

0

[ "NCBIFAM" ]

[ "NF040988" ]

[ "MamL" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00105201" ]

[ "27286560" ]

[ "Genetic and Ultrastructural Analysis Reveals the Key Players and Initial Steps of Bacterial Magnetosome Membrane Biogenesis." ]

[ 2016 ]

1

[]

0

null

[ "Rhodospirillales" ]

[ 10 ]

1

[]

0

true

Family

Magnetosome protein MamL, Rhodospirillales

MamL_Rhodospirillales

8

IPR060787

60,787

Magnetosome protein MamJ

MamJ

Family

11

false

This entry represents Magnetosome protein MamJ proteins together with which also represents magnetosome related proteins. Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic en...

[]

0

[ "NCBIFAM" ]

[ "NF040987" ]

[ "MamJ" ]

[ 11 ]

1

[]

0

[]

0

[ "PUB00105201", "PUB00106117" ]

[ "27286560", "16299495" ]

[ "Genetic and Ultrastructural Analysis Reveals the Key Players and Initial Steps of Bacterial Magnetosome Membrane Biogenesis.", "An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria." ]

[ 2016, 2006 ]

2

[]

0

null

[ "Rhodospirillales" ]

[ 11 ]

1

[]

0

true

Family

Magnetosome protein MamJ

MamJ

1

IPR060788

60,788

Type III secretion system early effector TepP

TepP

Family

9

false

The virulence factor TepP (Translocated Early PhosphoProtein), a type III secretion system (T3SS) effector, is the most abundant effector secreted early in chlamydial intracellular infection. TepP recruits host scaffolding proteins and class I phosphoinositide 3-kinases (PI3K) to pathogen-containing vacuoles and activa...

[]

0

[ "NCBIFAM" ]

[ "NF049855" ]

[ "T3SS_effe_TepP" ]

[ 9 ]

1

[]

0

[]

0

[ "PUB00163117", "PUB00163118" ]

[ "24586162", "28744480" ]

[ "The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling.", "The Effector TepP Mediates Recruitment and Activation of Phosphoinositide 3...

[ 2014, 2017 ]

2

[]

0

null

[ "Chlamydia" ]

[ 9 ]

1

[]

0

true

Family

Type III secretion system early effector TepP

TepP

8

IPR060796

60,796

Transcriptional activator TdcR

TdcR

Family

136

false

This entry represents TdcR transcriptional activator and related proteins. TdcR participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; lacks obvious DNA-binding regions or detectable homology to other known transcription factors. TdcR affects the tdcABCDEFG operon, ...

[]

0

[ "NCBIFAM" ]

[ "NF008507" ]

[ "PRK11424.1" ]

[ 136 ]

1

[]

0

[]

0

[ "PUB00104731" ]

[ "7928991" ]

[ "Functional analysis of the tdcABC promoter of Escherichia coli: roles of TdcA and TdcR." ]

[ 1994 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 136 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcriptional activator TdcR

TdcR

3

IPR060798

60,798

TraS

Family

110

false

TraS, as the term is used in F-like plasmids, is a plasmid entry exclusion protein. It interacts with the F-like plasmid mating stabilization protein TraG [ ]].

[]

0

[ "NCBIFAM" ]

[ "NF010304" ]

[ "PRK13741.1" ]

[ 110 ]

1

[]

0

[]

0

[ "PUB00044521" ]

[ "17259615" ]

[ "Entry exclusion in F-like plasmids requires intact TraG in the donor that recognizes its cognate TraS in the recipient." ]

[ 2007 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 110 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TraS

4

IPR060799

60,799

YccE-like

Family

105

false

This entry represents YccE, a predicted protein found in Escherichia coli and other Enterobacterales.

[]

0

[ "NCBIFAM" ]

[ "NF007304" ]

[ "PRK09784.1" ]

[ 105 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacteriaceae" ]

[ 105 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YccE-like

5

IPR060802

60,802

DNA damage response protein C

DdrC

Family

77

false

This entry represents DdrC, a DNA damage-induced nucleoid-associated protein (NAP) restricted to the genus Deinococcus. DdrC contributes to the extreme radioresistance of Deinococcus species by promoting nucleoid compaction following exposure to ionizing radiation. The protein bridges DNA duplexes, thereby limiting dis...

[]

0

[ "NCBIFAM" ]

[ "NF033622" ]

[ "repair_DdrC" ]

[ 77 ]

1

[]

0

[ "7qvb", "7udi", "8u0g" ]

3

[ "PUB00056127", "PUB00105203", "PUB00163211" ]

[ "15454524", "28542368", "35801857" ]

[ "Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance.", "In vivo and in vitro characterization of DdrC, a DNA damage response protein in Deinococcus radiodurans bacterium.", "Structural and functio...

[ 2004, 2017, 2022 ]

3

[]

0

null

[ "Deinococci" ]

[ 77 ]

1

[]

0

true

Family

DNA damage response protein C

DdrC

2

IPR060810

60,810

Uncharacterized protein YobI

YobI

Family

42

false

This entry represents YobI from Enterobacterales. Yobl is a small hydrophobic protein whose expression increases after heat shock [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF038179" ]

[ "stress_YobI" ]

[ 42 ]

1

[]

0

[]

0

[ "PUB00104040", "PUB00104946" ]

[ "19734316", "19121005" ]

[ "Small stress response proteins in Escherichia coli: proteins missed by classical proteomic studies.", "Small membrane proteins found by comparative genomics and ribosome binding site models." ]

[ 2010, 2008 ]

2

[]

0

null

[ "Enterobacteriaceae" ]

[ 42 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterized protein YobI

YobI

3

IPR060812

60,812

Cell division inhibitor SidA

SidA

Family

31

false

This entry represents SidA (SOS-induced inhibitor of cell division A) found in Caulobacter and Phenylobacterium. SidA inhibits cell division by binding directly to FtsW to prevent the final constriction of the FtsZ ring [ , , ].

[]

0

[ "NCBIFAM" ]

[ "NF033228" ]

[ "div_inhib_SidA" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00105037", "PUB00105039", "PUB00151407" ]

[ "24606146", "21685367", "25350732" ]

[ "Small proteins can no longer be ignored.", "A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW.", "A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus." ]

[ 2014, 2011, 2014 ]

3

[]

0

null

[ "Caulobacteraceae" ]

[ 31 ]

1

[]

0

true

Family

Cell division inhibitor SidA

SidA

7

IPR060814

60,814

YadW

Family

29

false

This entry represents YadW, a small protein of unknown function found in Escherichia coli and related species. The gene encoding YadW is located adjacent to a transporter gene, a genomic context commonly observed for small membrane proteins. YadW contains an N-terminal hydrophobic region followed by an amphipathic segm...

[]

0

[ "NCBIFAM" ]

[ "NF040926" ]

[ "small_YadW" ]

[ 29 ]

1

[]

0

[]

0

[ "PUB00106067" ]

[ "29645342" ]

[ "Identifying New Small Proteins in Escherichia coli." ]

[ 2018 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 29 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YadW

6

IPR060816

60,816

S-layer protein VapA

S-layer_VapA

Family

42

false

This entry represents VapA (virulence array protein gene A) found in fish pathogen Aeromonas salmonicida. VpA is both a paracrystalline surface array-forming protein (S-layer protein) and a virulence factor [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF050048" ]

[ "S_layer_VapA" ]

[ 42 ]

1

[]

0

[]

0

[ "PUB00162656", "PUB00162657" ]

[ "1869553", "1730607" ]

[ "Structure of the tetragonal surface virulence array protein and gene of Aeromonas salmonicida.", "Binding of laminin and fibronectin by the trypsin-resistant major structural domain of the crystalline virulence surface array protein of Aeromonas salmonicida." ]

[ 1991, 1992 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 42 ]

1

[]

0

true

Family

S-layer protein VapA

S-layer_VapA

3

IPR060817

60,817

Microcin J25

J25

Family

19

false

This entry represents the precursor peptides of lasso peptide antibiotics, including microcin J25, acinetodin, and klebsidin. These peptides inhibit bacterial DNA-dependent RNA polymerase (RNAP) by binding deep within the RNAP secondary channel, where they sterically block folding of the trigger loop essential for effi...

[]

0

[ "NCBIFAM" ]

[ "NF033471" ]

[ "J25_fam_lasso" ]

[ 19 ]

1

[]

0

[ "1pp5", "1q71", "2mmt", "2mmw", "4cu4", "5ui6", "5ui7", "6n60", "6por", "8dyn", "9nwz", "9ny3" ]

12

[ "PUB00076764", "PUB00105117", "PUB00105118", "PUB00163213", "PUB00163214", "PUB00163215", "PUB00163216", "PUB00163217", "PUB00163218" ]

[ "10198038", "28106375", "8655570", "11443089", "11731133", "12401787", "1429464", "15200952", "30626643" ]

[ "Sequence analysis of the four plasmid genes required to produce the circular peptide antibiotic microcin J25.", "Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.", "Genetic analysis of plasmid determinants for ...

[ 1999, 2017, 1996, 2001, 2001, 2002, 1992, 2004, 2019 ]

9

[]

0

null

[ "Pseudomonadota" ]

[ 19 ]

1

[]

0

true

Family

Microcin J25

J25

3

IPR060818

60,818

RP439

Family

18

false

This entry represents Uncharacterized protein RP439 which is upregulated in human cell lines [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047993" ]

[ "RP439FamHumup" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00163028" ]

[ "28709615" ]

[ "Transcriptional profiling of Rickettsia prowazekii coding and non-coding transcripts during in vitro host-pathogen and vector-pathogen interactions." ]

[ 2017 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2, 16 ]

2

[]

0

true

Family

RP439

8

IPR060819

60,819

Bacteriocin microcin B17

B17

Family

17

false

Microcin B17 is a thiazole/oxazole modified microcin (TOMM), a type of ribosomally synthesized and post-translationally modified peptide natural product (RiPP). It is a toxin that corrupts gyrase activity and causes gyrase to to cleave chromosomal DNA, killing the cell [ ].

[]

0

[ "NCBIFAM" ]

[ "NF041037" ]

[ "microcin_B17" ]

[ 17 ]

1

[]

0

[ "6gos", "6grg", "6grh" ]

3

[ "PUB00041976", "PUB00106144" ]

[ "9545435", "1846808" ]

[ "Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26.", "The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase." ]

[ 1998, 1991 ]

2

[]

0

null

[ "Enterobacteriaceae" ]

[ 17 ]

1

[]

0

true

Family

Bacteriocin microcin B17

B17

7

IPR060820

60,820

YonT

Family

16

false

YonT, encoded in a prophage region in Bacillus subtilis, is type I toxin-antitoxin (TA) system about 59 amino acids in length [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047537" ]

[ "YonT_type_I_tox" ]

[ 16 ]

1

[]

0

[]

0

[ "PUB00159439" ]

[ "29414903" ]

[ "Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression." ]

[ 2018 ]

1

[]

0

null

[ "Bacillus", "Bacillus phage SPbeta" ]

[ 15, 1 ]

2

[]

0

true

Family

YonT

8

IPR060821

60,821

Cypemycin

Family

15

false

This entry represents CypA, the precursor peptide of cypemycin and related linaridins. Linaridins are linear, dehydrated, ribosomally synthesised and post-translationally modified peptides (RiPPs) structurally related to lantibiotics. The precursor contains a conserved C-terminal CL[VI]C motif that undergoes decarboxyl...

[]

0

[ "NCBIFAM" ]

[ "NF033752" ]

[ "linaridin_CypA" ]

[ 15 ]

1

[]

0

[]

0

[ "PUB00105300", "PUB00105301" ]

[ "20805503", "7802859" ]

[ "Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.", "A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics." ]

[ 2010, 1993 ]

2

[]

0

null

[ "Actinomycetes" ]

[ 15 ]

1

[]

0

true

Family

Cypemycin

3

IPR060822

60,822

Bottromycin D

Bottromycin_D

Family

13

false

Bottromycin D is a ribosomally synthesised and post-translationally modified peptide (RiPP) that displays antibiotic activity against methicillin-resistant S.aureus (MRSA) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033414" ]

[ "bottro_RiPP" ]

[ 13 ]

1

[]

0

[]

0

[ "PUB00105079", "PUB00105080" ]

[ "22984777", "27653442" ]

[ "Structure and biosynthesis of the antibiotic bottromycin D.", "Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP." ]

[ 2012, 2016 ]

2

[]

0

null

[ "Actinomycetes" ]

[ 13 ]

1

[]

0

true

Family

Bottromycin D

Bottromycin_D

9

IPR060823

60,823

Trp operon leader peptide

Trp_leader

Family

6

false

This entry describes trp operon leader peptide in Sinohizobium meliloti and other alphaproteobacteria. In Sinohizobium meliloti, tryptophan biosynthesis genes are divided into three different operons, and only the trpE-encoding operon is preceded by a leader peptide, designated TrpLE [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038137" ]

[ "leader_TrpLE_al" ]

[ 6 ]

1

[]

0

[]

0

[ "PUB00002084", "PUB00105569" ]

[ "2656657", "32546623" ]

[ "Rhizobium meliloti anthranilate synthase gene: cloning, sequence, and expression in Escherichia coli.", "The Leader Peptide peTrpL Forms Antibiotic-Containing Ribonucleoprotein Complexes for Posttranscriptional Regulation of Multiresistance Genes." ]

[ 1989, 2020 ]

2

[]

0

null

[ "Rhizobiaceae" ]

[ 6 ]

1

[]

0

true

Family

Trp operon leader peptide

Trp_leader

8

IPR060825

60,825

Trifolitoxin

Family

2

false

Trifolitoxin is a ribosomally synthesised and post-translationally modified peptide natural product (RiPP) antibiotic produced by some strains of Rhizobium and active against others [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF033430" ]

[ "TfxA_RiPP" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00105096", "PUB00105097" ]

[ "16665698", "8509324" ]

[ "Trifolitoxin Production and Nodulation Are Necessary for the Expression of Superior Nodulation Competitiveness by Rhizobium leguminosarum bv. trifolii Strain T24 on Clover.", "DNA sequence and mutational analysis of genes involved in the production and resistance of the antibiotic peptide trifolitoxin." ]

[ 1987, 1993 ]

2

[]

0

null

[ "Rhizobium" ]

[ 2 ]

1

[]

0

true

Family

Trifolitoxin

8

IPR060826

60,826

Precursor peptide TigB

TigB

Family

2

false

The precursor peptide TigB undergoes radical SAM enzyme-catalyzed post-translational modification to create methyl-cyclopropylglycine moieties from the isoleucine residues in its repeating TIGSVS hexapeptides [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047709" ]

[ "RiPP_TigB" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00159677" ]

[ "38295270" ]

[ "Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases." ]

[ 2024 ]

1

[]

0

null

[ "Caminicellaceae" ]

[ 2 ]

1

[]

0

true

Family

Precursor peptide TigB

TigB

3

IPR060827

60,827

Trp operon leader peptide, Corynebacterium

TrpL_Coryne

Family

2

false

Member of this family are tryptophan biosynthesis operon leader peptide TrpL, as found in the genus Corynebacterium. It differs substantially from Trp-rich leader peptides documented in other lineages, such as in the gammaproteobacteria.

[]

0

[ "NCBIFAM" ]

[ "NF038152" ]

[ "TrpL_Coryne" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00105580", "PUB00153492", "PUB00153493" ]

[ "7683184", "3609747", "3667535" ]

[ "Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence.", "Structure and function of the trp operon control regions of Brevibacterium lactofermentum, a glutamic-acid-producing bacterium.", "Two single-base-p...

[ 1993, 1987, 1987 ]

3

[]

0

null

[ "Corynebacterium" ]

[ 2 ]

1

[]

0

true

Family

Trp operon leader peptide, Corynebacterium

TrpL_Coryne

8

IPR060828

60,828

SCO3933

Family

1,662

false

Proteins of this entry are conserved in Streptomyces and closely related species. The gene encoding SCO3933 family regulatory protein is typically located immediately upstream or downstream of a gene encoding a GntR family transcriptional regulator [ ].

[]

0

[ "NCBIFAM" ]

[ "NF051478" ]

[ "SCO3933_fam" ]

[ 1662 ]

1

[]

0

[]

0

[ "PUB00162814" ]

[ "34769298" ]

[ "GntR-like SCO3932 Protein Provides a Link between Actinomycete Integrative and Conjugative Elements and Secondary Metabolism." ]

[ 2021 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 1662 ]

1

[]

0

true

Family

SCO3933

8

IPR060829

60,829

Aa3-type cytochrome oxidase subunit CtaJ

CtaJ

Family

1,268

false

CtaJ is found in Mycobacterium tuberculosis and related Actinobacteria in structures of the cytochrome bcc-aa3 supercomplex, and has been called both an accessory protein and a structural subunit.

[]

0

[ "NCBIFAM" ]

[ "NF050118" ]

[ "aa3_CtaJ_Mycob" ]

[ 1268 ]

1

[]

0

[ "6adq", "6hwh", "7e1v", "7e1w", "7e1x", "7rh5", "7rh6", "7rh7", "8hcr", "8ovc", "8ovd", "9dm1", "9ftz", "9fu0", "9gy6" ]

15

[ "PUB00162841", "PUB00162842" ]

[ "34819223", "37158740" ]

[ "Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates.", "Cryo-Electron Microscopy Structure of the Mycobacterium tuberculosis Cytochrome bcc:aa3 Supercomplex and a Novel Inhibitor Targeting Subunit Cytochro...

[ 2021, 2023 ]

2

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 1266, 2 ]

2

[]

0

true

Family

Aa3-type cytochrome oxidase subunit CtaJ

CtaJ

8

IPR060831

60,831

PA4570

Family

706

false

Proteins of this family are conserved short proteins found in Gamma-proteobacteria with unknown function.

[]

0

[ "NCBIFAM" ]

[ "NF050178" ]

[ "PA4570_fam" ]

[ 706 ]

1

[]

0

[]

0

[ "PUB00162755", "PUB00162756" ]

[ "35891650", "29866805" ]

[ "The function of small RNA in Pseudomonas aeruginosa.", "RsmV, a Small Noncoding Regulatory RNA in Pseudomonas aeruginosa That Sequesters RsmA and RsmF from Target mRNAs." ]

[ 2022, 2018 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 706 ]

1

[]

0

true

Family

PA4570

3

IPR060832

60,832

Gene transfer agent protein-like

Gene_transfer_agent

Family

477

false

This entry represents predicted Gene transfer agent protein and related uncharacterised proteins. This protein is a 77 amino acid protein encoded in the head region of a (phage-like) gene transfer agent from a class widespread in alphaproteobacteria. Absence of this protein results in (incorrectly formed) oblate capsid...

[]

0

[ "NCBIFAM" ]

[ "NF048001" ]

[ "GTP_morpho_1" ]

[ 477 ]

1

[]

0

[]

0

[ "PUB00153971" ]

[ "32541663" ]

[ "Structure and mechanism of DNA delivery of a gene transfer agent." ]

[ 2020 ]

1

[]

0

null

[ "Rhodobacterales", "Rhodogtaviriformidae", "ecological metagenomes" ]

[ 469, 4, 4 ]

3

[]

0

true

Family

Gene transfer agent protein-like

Gene_transfer_agent

5

IPR060833

60,833

Lipoprotein BTA121, duplicated domain

Lipo_BTA121_dup

Domain

335

false

This entry describes an uncharacterised domain found mostly in Borrelia. It appears from 2 to 14 times in surface lipoproteins such as BTA121 of Borrelia turicatae. It contains an helical fold [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047534" ]

[ "lipo_BTA121_dup" ]

[ 335 ]

1

[]

0

[ "5vj4" ]

1

[ "PUB00159295" ]

[ "29127407" ]

[ "Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes." ]

[ 2017 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 335 ]

1

[]

0

true

Domain

Lipoprotein BTA121, duplicated domain

Lipo_BTA121_dup

2

IPR060835

60,835

PPC1 domain

PPC1_domain

Domain

272

false

This entry represents the so-called PPC1 domain. The PEP-CTERM domain is a protein-sorting domain, about 25 amino acids in length, typically found as the most C-terminal domain feature in any bacterial protein. However, a subset of choice-of-anchor J family proteins with PEP-CTERM domains have an additional, extremely ...

[]

0

[ "NCBIFAM" ]

[ "NF047450" ]

[ "post-PEP-CTERM_1" ]

[ 272 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 272 ]

1

[]

0

true

Domain

PPC1 domain

PPC1_domain

3

IPR060837

60,837

Choice-of-anchor H domain

H_dom

Domain

249

false

This entry represents the choice-of-anchor H domain. This domain is observed, in from one to four copies, in proteobacterial proteins with a C-terminal protein sorting signal, GlyGly-CTERM, that directs processing by rhombosortase, transport by a type II secretion system (T2SS), and (most likely) covalent attachment to...

[]

0

[ "NCBIFAM" ]

[ "NF038116" ]

[ "Sden1266_dom" ]

[ 249 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 247, 2 ]

2

[]

0

true

Domain

Choice-of-anchor H domain

H_dom

1

IPR060840

60,840

PA0613

Family

223

false

Proteins of this family are conserved across Pseudomonas species. The encoding genes of PA0613 family proteins are on the pyocin operon [ ].

[]

0

[ "NCBIFAM" ]

[ "NF051483" ]

[ "PA0613_fam" ]

[ 223 ]

1

[]

0

[]

0

[ "PUB00012947" ]

[ "12423794" ]

[ "The pyocins of Pseudomonas aeruginosa." ]

[ 2002 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 223 ]

1

[]

0

true

Family

PA0613

1

IPR060841

60,841

A1S_1983

Family

216

false

This entry represents uncharacterised bacterial proteins (A1S_1983). These proteins average 215 amino acids in length. They contain six invariant Cys residues, which suggest a disulphide bond formation. Mutational studies suggest that this protein contributes to resistance to the antibiotic colistin [ ].

[]

0

[ "NCBIFAM" ]

[ "NF049887" ]

[ "A1S_1983_colist" ]

[ 216 ]

1

[]

0

[]

0

[ "PUB00163059" ]

[ "27847502" ]

[ "The Effect of Colistin Resistance-Associated Mutations on the Fitness of Acinetobacter baumannii." ]

[ 2016 ]

1

[]

0

null

[ "Acinetobacter", "Caenorhabditis remanei" ]

[ 215, 1 ]

2

[]

0

true

Family

A1S_1983

3

IPR060842

60,842

BlhA

Family

207

false

This entry represents uncharacterised bacterial proteins, including cell division protein BlhA which has been implicated in β-lactam resistance [ ].

[]

0

[ "NCBIFAM" ]

[ "NF049876" ]

[ "CellDivBlhA" ]

[ 207 ]

1

[]

0

[]

0

[ "PUB00163058" ]

[ "27067318" ]

[ "Mutations Decreasing Intrinsic β-Lactam Resistance Are Linked to Cell Division in the Nosocomial Pathogen Acinetobacter baumannii." ]

[ 2016 ]

1

[]

0

null

[ "Acinetobacter" ]

[ 207 ]

1

[]

0

true

Family

BlhA

6

IPR060843

60,843

Copper uptake system-associated domain

Copper_dom

Domain

209

false

This entry represents an uncharacterised domain in bacterial proteins. This domain can be found as a single domain after a N-terminal signal peptide. This domain can also be found at the C-terminal. Most bacteria that make a peptide-type methanobactin precursor also have a protein from this family, which strongly impli...

[]

0

[ "NCBIFAM" ]

[ "NF033672" ]

[ "mbn_chaper_assoc" ]

[ 209 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pentapetalae", "Pseudomonadati" ]

[ 2, 207 ]

2

[]

0

true

Domain

Copper uptake system-associated domain

Copper_dom

7

IPR060845

60,845

RGCVC-like

Domain

170

false

This entry represents small proteins, averaging just over 60 amino acids in length, has conspicuous motifs CxxCxH, HD, and RGCVC. The last motif, for which this entry is named, is distinctive. This entry appears in GC-rich bacteria. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF038206" ]

[ "RGCVC_fam" ]

[ 170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 169, 1 ]

2

[]

0

true

Domain

RGCVC-like

2

IPR060848

60,848

SrpA

Family

151

false

This entry represents SrpA. It has been reported that the expression of three genes, including srpA, srpB, and srpC, was regulated by the sigma factor SigX and anti-sigma factor Rsx in pathogenic species of Leptospira [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047529" ]

[ "SrpA" ]

[ 151 ]

1

[]

0

[]

0

[ "PUB00159362" ]

[ "33301041" ]

[ "4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans." ]

[ 2020 ]

1

[]

0

null

[ "Leptospiraceae" ]

[ 151 ]

1

[]

0

true

Family

SrpA

7

IPR060849

60,849

Alvin_2107

Family

151

false

This entry represents Alvin_2107 in the purple sulphur bacterium Allochromatium vinosum. This protein is induced highly by growth on sulphide or thiosulphate. It was shown to be essential for the oxidation of sulphur stored in globules [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF049856" ]

[ "Alvin2107_sulfur" ]

[ 151 ]

1

[]

0

[]

0

[ "PUB00162901", "PUB00162902" ]

[ "24487535", "23873913" ]

[ "A comparative quantitative proteomic study identifies new proteins relevant for sulfur oxidation in the purple sulfur bacterium Allochromatium vinosum.", "Genome-wide transcriptional profiling of the purple sulfur bacterium Allochromatium vinosum DSM 180T during growth on different reduced sulfur compounds." ]

[ 2014, 2013 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 123, 28 ]

2

[]

0

true

Family

Alvin_2107

1

IPR060851

60,851

Athe_2463 domain

Athe_2463_dom

Domain

150

false

This entry represents an uncharacterised protein domain in Bacillota. It is usually found at the N-terminal domain. This entry includes Athe_2463 from Caldicellulosiruptor bescii, becomes highly abundant during growth on the five-carbon sugar xylose or on xylan, a beta-1,4 xylose polymer [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047340" ]

[ "Athe_2463_dom" ]

[ 150 ]

1

[]

0

[]

0

[ "PUB00159149" ]

[ "29588665" ]

[ "The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate." ]

[ 2018 ]

1

[]

0

null

[ "Bacillota" ]

[ 150 ]

1

[]

0

true

Domain

Athe_2463 domain

Athe_2463_dom

6

IPR060871

60,871

Choice-of-anchor F

Choice_anch_F

Domain

128

false

Choice-of-anchor F is a domain found in prokaryotic proteins with a variety of C-terminal sorting and transit domains. These include the autotransporter outer membrane β-barrel domain, the JDVT-CTERM domain, and variant forms of PEP-CTERM domains.

[]

0

[ "NCBIFAM" ]

[ "NF033657" ]

[ "choice_anch_F" ]

[ 128 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Amphora coffeiformis", "Bacteria", "hydrothermal vent metagenome" ]

[ 2, 125, 1 ]

3

[]

0

true

Domain

Choice-of-anchor F

Choice_anch_F

2

IPR060886

60,886

FAD-I protein

FAD_I

Family

132

false

FAD-I (see NBR016095), described in Fusobacterium nucleatum, is a lipoprotein shown to engage Toll-like receptors of the human host, triggering responses that include the production of beta-defensin. This entry describes a region shared by a number of both lipoproteins such as FAD-I and related non-lipoproteins in gene...

[]

0

[ "NCBIFAM" ]

[ "NF041845" ]

[ "lipo_FAD_I_fam" ]

[ 132 ]

1

[]

0

[]

0

[ "PUB00152951", "PUB00152952", "PUB00152953" ]

[ "31906541", "20847052", "26930710" ]

[ "Role of FAD-I in Fusobacterial Interspecies Interaction and Biofilm Formation.", "Fusobacterium nucleatum-associated beta-defensin inducer (FAD-I): identification, isolation, and functional evaluation.", "FAD-I, a Fusobacterium nucleatum Cell Wall-Associated Diacylated Lipoprotein That Mediates Human Beta Defe...

[ 2020, 2010, 2016 ]

3

[]

0

null

[ "Bacteria" ]

[ 132 ]

1

[]

0

true

Family

FAD-I protein

FAD_I

6

IPR060889

60,889

RtxH

Family

117

false

The RtxH protein is encoded by the rtxH gene on the rtxACHBDE gene cluster. The biological function of RtxH is not fully understood. It has been shown that the expression of rtxH and other rtx genes was controlled by the positive regulator HlyU ( ).

[]

0

[ "NCBIFAM" ]

[ "NF051470" ]

[ "RtxH" ]

[ 117 ]

1

[]

0

[]

0

[ "PUB00014739", "PUB00159512" ]

[ "9927695", "19320834" ]

[ "Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.", "HlyU acts as an H-NS antirepressor in the regulation of the RTX toxin gene essential for the virulence of the human pathogen Vibrio vulnificus CMCP6." ]

[ 1999, 2009 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 117 ]

1

[]

0

true

Family

RtxH

2

IPR060891

60,891

MHO_1590, C-terminal

MHO_1590_C

Domain

119

false

Members of this family average about 145 amino acids in length, with a signal peptide, a variable length low-complexity region rich in N, D, Q, E, K, and R, and the roughly 80 amino acid C-terminal region described by this entry. A few members of the family have candidate lipoprotein signal peptides. The family is name...

[]

0

[ "NCBIFAM" ]

[ "NF045957" ]

[ "MHO_1590_dom" ]

[ 119 ]

1

[]

0

[]

0

[ "PUB00159795" ]

[ "23710536" ]

[ "Diversity of Mycoplasma hominis clinical isolates from Bordeaux, France, as assessed by multiple-locus variable-number tandem repeat analysis." ]

[ 2013 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 119 ]

1

[]

0

true

Domain

MHO_1590, C-terminal

MHO_1590_C

4

IPR060894

60,894

LB_137 protein

LB_137-like

Family

117

false

Members of this family occur in the genus Leptospira, and include LB_137 ( ) from chromosome II of Leptospira interrogans serovar Lai str. 56601. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF047503" ]

[ "LB_137_fam" ]

[ 117 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 117 ]

1

[]

0

true

Family

LB_137 protein

LB_137-like

2

IPR060895

60,895

LA_1737 protein, C-terminal

LA_1737_C

Domain

117

false

This HMM represents a well-conserved C-terminal block of aligned sequence, about 160 amino acids long, from LA_1737 and homologs, all from Leptospira. Most full-length members of this family are between 1200 and 1800 amino acids in length.

[]

0

[ "NCBIFAM" ]

[ "NF047486" ]

[ "LA_1737_Cterm" ]

[ 117 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospiraceae" ]

[ 117 ]

1

[]

0

true

Domain

LA_1737 protein, C-terminal

LA_1737_C

4

IPR060897

60,897

LIC_11321 protein

LIC_11321-like

Family

115

false

This protein family appears restricted to the genus Leptospira, but is nearly always present in that lineage. Most members of the family appear to have either a type I (regular) or type II (lipoprotein) signal peptide. This entry omits the signal peptide region and an adjacent short region of low-complexity sequence. A...

[]

0

[ "NCBIFAM" ]

[ "NF047538" ]

[ "LIC_11321_fam" ]

[ 115 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 115 ]

1

[]

0

true

Family

LIC_11321 protein

LIC_11321-like

3

IPR060900

60,900

LIC_11695/LIC_11696 lipoprotein

LIC11695-like

Family

115

false

Members of this family are lipoproteins found broadly in the genus Leptospira. Two paralogs, LIC_11695 and LIC_11696 are found in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 (a well-studied reference strain), where they are encoded by tandem genes, and are among the 25 proteins whose expression is up...

[]

0

[ "NCBIFAM" ]

[ "NF033167" ]

[ "lipo_LIC11695" ]

[ 115 ]

1

[]

0

[]

0

[ "PUB00105014" ]

[ "17371863" ]

[ "Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition." ]

[ 2007 ]

1

[]

0

null

[ "Leptospira" ]

[ 115 ]

1

[]

0

true

Family

LIC_11695/LIC_11696 lipoprotein

LIC11695-like

5

IPR060901

60,901

MAG1210-like

Family

115

false

Members of this family are found mostly within Mycoplasma and similar bacterial proteins, but occasionally in other lineages.

[]

0

[ "NCBIFAM" ]

[ "NF046000" ]

[ "MAG1210_fam" ]

[ 115 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 112, 3 ]

2

[]

0

true

Family

MAG1210-like

8

IPR060902

60,902

Immunity protein BlpZ

BlpZ-like

Family

112

false

BlpZ, also called PncQ, is an putative membrane protein, apparently an immunity protein, encoded within the larger BLP (Bacteriocin-Like Peptide) locus, in Streptococcus pneumoniae and related species that produces bacteriocins such as BlpE, BlpI, BlpK, BlpN, etc., plus various immunity proteins. Some members of this f...

[]

0

[ "NCBIFAM" ]

[ "NF042932" ]

[ "BlpZ_fam" ]

[ 112 ]

1

[]

0

[]

0

[ "PUB00153454", "PUB00153456" ]

[ "17704229", "30910792" ]

[ "Diversity of bacteriocins and activity spectrum in Streptococcus pneumoniae.", "Prediction and Validation of Immunogenic Domains of Pneumococcal Proteins Recognized by Human CD4+ T Cells." ]

[ 2007, 2019 ]

2

[]

0

null

[ "Bacteria" ]

[ 112 ]

1

[]

0

true

Family

Immunity protein BlpZ

BlpZ-like

7

IPR060905

60,905

LOFI repeat

LoFi_rpt

Repeat

120

false

This weakly conserved (low-fidelity, or LOFI) repeat appears primarily in Campylobacteria, but not exclusively, in proteins such as Cj0967, Cj0736, and Cj0735. This entry represents a core region about 23 residues in length of repeats whose lengths vary typically between 35 and 50 residues in length.

[]

0

[ "NCBIFAM" ]

[ "NF038205" ]

[ "Campy_LoFi_RPT" ]

[ 120 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 120 ]

1

[]

0

true

Repeat

LOFI repeat

LoFi_rpt

3

IPR060909

60,909

MGA_1079 surface serine endopeptidase, C-terminal domain

MGA1079_C

Domain

114

false

MGA_1079 from Mycoplasma gallisepticum str. R, the founding member of this family, was identified as one of two putative peptidases in the strain, with a trypsin-like peptidase motif in the 900 amino acid C-terminal homology domain it shares exclusively with other members of the Mycoplasmoidales. Full-length members of...

[]

0

[ "NCBIFAM" ]

[ "NF045847" ]

[ "MGA1079_SerProt" ]

[ 114 ]

1

[]

0

[]

0

[ "PUB00159776", "PUB00159777" ]

[ "28348054", "33704021" ]

[ "The oppD Gene and Putative Peptidase Genes May Be Required for Virulence in Mycoplasma gallisepticum.", "Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors." ]

[ 2017, 2021 ]

2

[]

0

null

[ "Mycoplasmatota" ]

[ 114 ]

1

[]

0

true

Domain

MGA_1079 surface serine endopeptidase, C-terminal domain

MGA1079_C

3

IPR060910

60,910

Exosortase-dependent surface domain 3 XDD3

XDD3

Domain

115

false

XDD3 (exosortase-dependent surface domain 3) is the third in a series of domains or full-length proteins that appear always, or nearly always, to have a C-terminal sorting signal such as PEP-CTERM or VPLPA-CTERM that is recognized and processed by an XrtA or another exosortase. Proteins sorted by exosortase are predict...

[]

0

[ "NCBIFAM" ]

[ "NF041930" ]

[ "Xrt_dep_XDD3" ]

[ 115 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 115 ]

1

[]

0

true

Domain

Exosortase-dependent surface domain 3 XDD3

XDD3

3

IPR060911

60,911

SAS053-like DNA gyrase inhibitor

SAS053_fam

Family

108

false

This entry represents small proteins found in Staphylococcus, Macrococcus, and Mammaliicoccus that occur in a conserved gene neighborhood, downstream of a larger uncharacterised protein distantly related to glucosamine-6-phosphate deaminases. It has been reported that this small protein is a type II toxin-antitoxin sys...

[]

0

[ "NCBIFAM" ]

[ "NF040875" ]

[ "SAS053_fam" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00106012", "PUB00159162", "PUB00159824" ]

[ "34061833", "31375497", "36148483" ]

[ "Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach.", "Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus.", "A novel gyrase inhibitor from toxin-antitoxin system expressed by Staphylococcus aure...

[ 2021, 2019, 2023 ]

3

[]

0

null

[ "Staphylococcaceae" ]

[ 108 ]

1

[]

0

true

Family

SAS053-like DNA gyrase inhibitor

SAS053_fam

4

IPR060914

60,914

Phage tail assembly chaperone GT, C-terminal domain

Tail_chap_PVL_C

Domain

105

false

A common motif in phage that rely on a tape measure protein to control the length of the tail tube is to have two tandem ORFs, with protein biosynthesis that makes the upstream protein, but a small percentage of the time undergoes a -1 frameshift at a slippery site near the C terminus and then continues through the dow...

[]

0

[ "NCBIFAM" ]

[ "NF047426" ]

[ "tail_chap_PVL_C" ]

[ 105 ]

1

[]

0

[]

0

[ "PUB00159571" ]

[ "15469818" ]

[ "Conserved translational frameshift in dsDNA bacteriophage tail assembly genes." ]

[ 2004 ]

1

[]

0

null

[ "Bacilli", "Viruses" ]

[ 75, 30 ]

2

[]

0

true

Domain

Phage tail assembly chaperone GT, C-terminal domain

Tail_chap_PVL_C

4

IPR060916

60,916

Dhp61 protein

Dhp61_prot

Family

105

false

Proteins of this family are exclusively encoded by the chromosomal marker dhp61 (locus BA_5345), which is widely used in distinguishing Bacillus species.

[]

0

[ "NCBIFAM" ]

[ "NF050138" ]

[ "marker_Dhp61" ]

[ 105 ]

1

[]

0

[]

0

[ "PUB00162765" ]

[ "29602786" ]

[ "Sensitive and Specific Recombinase Polymerase Amplification Assays for Fast Screening, Detection, and Identification of Bacillus anthracis in a Field Setting." ]

[ 2018 ]

1

[]

0

null

[ "Bacillus" ]

[ 105 ]

1

[]

0

true

Family

Dhp61 protein

Dhp61_prot

2

IPR060917

60,917

Small membrane protein MtfM

MtfM

Family

103

false

Members of this family are typically 34 amino acids in length, consisting largely of one highly hydrophobic predicted transmembrane segment. Many are from the genera Micromonospora and Actinoplanes. Note that many annotation pipelines are unable to predict a bacterial protein this small without supporting homology evid...

[]

0

[ "NCBIFAM" ]

[ "NF041280" ]

[ "mem_Micro_34" ]

[ 103 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Micromonosporaceae" ]

[ 103 ]

1

[]

0

true

Family

Small membrane protein MtfM

MtfM

4

IPR060919

60,919

KPN_01571 protein

KPN_01571-like

Family

107

false

Members of this family are very small, highly hydrophobic proteins regularly encoded adjacent to transporters and likely to be previously overlooked small subunits of transporters.

[]

0

[ "NCBIFAM" ]

[ "NF033695" ]

[ "trnsprt_adja_30" ]

[ 107 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacteriaceae" ]

[ 107 ]

1

[]

0

true

Family

KPN_01571 protein

KPN_01571-like

8

IPR060922

60,922

HHHH-motif protein

HHHH-motif_fam

Family

95

false

Proteins in this family are small in size, averaging just 46 amino acids in length, half of which belongs to an apparent signal peptide. The C-terminal region contains two invariant Cys residues, and between them, an HHHH motif, unusual in such a small protein. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF040554" ]

[ "mini_HHHH" ]

[ 95 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Burkholderiales" ]

[ 95 ]

1

[]

0

true

Family

HHHH-motif protein

HHHH-motif_fam

9

IPR060924

60,924

LIC_13346-like putative lipoprotein

LIC_13346-like

Family

93

false

Members of this family, broadly distributed in Leptospira, are uncharacterised, but appear to be lipoproteins.

[]

0

[ "NCBIFAM" ]

[ "NF047502" ]

[ "LIC_13346_fam" ]

[ 93 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 93 ]

1

[]

0

true

Family

LIC_13346-like putative lipoprotein

LIC_13346-like

9

IPR060925

60,925

KGW motif small protein

KGW_motif-containing

Family

93

false

Members of this family of small proteins are found in acinetobacter. The family is named for KGW motif that is its best-conserved motif, at the midpoint of the 40 amino acid length sequence. C-terminal to that motif, the sequence is extremely hydrophobic. Members are found encoded next to a YqfO/Nif3 family protein. Th...

[]

0

[ "NCBIFAM" ]

[ "NF040911" ]

[ "KGW_Acineto" ]

[ 93 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Acinetobacter" ]

[ 93 ]

1

[]

0

true

Family

KGW motif small protein

KGW_motif-containing

8

IPR060932

60,932

Lmo1799-like Asp-Ala repeat surface protein, N-terminal domain

Lmo1799-like_N

Domain

135

false

Members of this family, including Lmo1799 from Listeria monocytogenes ( ), are sortase-dependent (LPXTG motif-containing) surface proteins of L.monocytogenes, present in some lineages only, and thought to contribute to stress survival and to virulence. A notable feature of this family is a variable length run of Asp-Al...

[]

0

[ "NCBIFAM" ]

[ "NF046114" ]

[ "DA_rpt_lmo1799" ]

[ 135 ]

1

[]

0

[]

0

[ "PUB00159311" ]

[ "21444667" ]

[ "LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes." ]

[ 2011 ]

1

[]

0

null

[ "Listeria" ]

[ 135 ]

1

[]

0

true

Domain

Lmo1799-like Asp-Ala repeat surface protein, N-terminal domain

Lmo1799-like_N

2

IPR060933

60,933

Exosortase U, C-terminal region

XrtU_C

Domain

92

false

This entry represents a distinctive C-terminal region found in the XrtU family of exosortases. Because members of the archaeosortase and exosortase family perform cleavage of target proteins, in pathways thought to lead to new covalent attachment at the C terminus and surface anchoring, this domain may indicate the pre...

[]

0

[ "NCBIFAM" ]

[ "NF033780" ]

[ "exosort_XrtU_C" ]

[ 92 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "PVC group", "hydrothermal vent metagenome" ]

[ 91, 1 ]

2

[]

0

true

Domain

Exosortase U, C-terminal region

XrtU_C

8

IPR060936

60,936

SE1626-like

Family

91

false

Members of this family, including SE1626 ( ) average about 59 amino acids in length, are restricted to Staphylococcus, and are encoded close to the pmtABCD genes that encode an export system for phenol-soluble modulins. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF047566" ]

[ "SE1626_fam" ]

[ 91 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Staphylococcus" ]

[ 91 ]

1

[]

0

true

Family

SE1626-like

4

IPR060937

60,937

MyrrCad domain

Myrrcad_dom

Domain

89

false

This domain appears at or near the C terminus in expanded paralogous families of proteins in Mycoplasma and Candidatus Mycoplasma. Proteins with this domain typically show an N-terminal sequence region followed by a repeat region, highly variable in length and similar to the leucine-rich repeat. The central region of t...

[]

0

[ "NCBIFAM" ]

[ "NF033158" ]

[ "Myrrcad" ]

[ 89 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 89 ]

1

[]

0

true

Domain

MyrrCad domain

Myrrcad_dom

4

IPR060938

60,938

Type IV secretion system effector BAB2_0123-like

T4SS_BAB2_0123-like

Family

91

false

Members of this family include BAB2_0123 ( ), a type IV secretion system (T4SS) effector from Brucella abortus that has been shown to interact with host cell alpha-enolase [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF046118" ]

[ "T4SS_BAB2_0123" ]

[ 91 ]

1

[]

0

[]

0

[ "PUB00159707", "PUB00159708" ]

[ "21707904", "27900285" ]

[ "In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system.", "A T4SS Effector Targets Host Cell Alpha-Enolase Contributing to Brucella abortus Intracellular Lifestyle." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Hyphomicrobiales" ]

[ 91 ]

1

[]

0

true

Family

Type IV secretion system effector BAB2_0123-like

T4SS_BAB2_0123-like

4

IPR060939

60,939

Rv1678-like membrane protein, C-terminal domain

Rv1678-like_C

Domain

89

false

This entry represents the C-terminal region of Rv1678 from Mycobacterium tuberculosis ( ), and its full-length homologues, as well as the the total length of shorter homologues. Proteins in this family are highly hydrophobic and thus predicted to be embedded in membrane. Member proteins tend to be encoded in a conserve...

[]

0

[ "NCBIFAM" ]

[ "NF049986" ]

[ "memb_Rv1678_C" ]

[ 89 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 89 ]

1

[]

0

true

Domain

Rv1678-like membrane protein, C-terminal domain

Rv1678-like_C

8

IPR060941

60,941

All3515-like Zur-repressed PEP-CTERM protein

All3515-like

Family

86

false

Full-length members of this family have an N-terminal signal peptide and a C-terminal PEP-CTERM (or related) recognition site for sorting and cleavage by exosortase, a probable transpeptidase for attachment to the outer membrane. The founding member of this family, all3515 from Anabaena sp. strain PCC 7120, showed the ...

[]

0

[ "NCBIFAM" ]

[ "NF040463" ]

[ "all3515_fam" ]

[ 86 ]

1

[]

0

[]

0

[ "PUB00105778" ]

[ "22389488" ]

[ "Characterization of the response to zinc deficiency in the cyanobacterium Anabaena sp. strain PCC 7120." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Symbiodinium pilosum" ]

[ 85, 1 ]

2

[]

0

true

Family

All3515-like Zur-repressed PEP-CTERM protein

All3515-like

9

IPR060950

60,950

Mhp366/Mhp367-like surface (lipo)protein

Mhp366_Mhp367-like

Family

80

false

This family is known so far only in the genus Mesomycoplasma, and includes examples of tandem paralogues, including Mhp366 ( ) and Mhp367 ( ). The majority of family members are lipoproteins, while the rest appear to have N-terminal signal-anchor sequences.

[]

0

[ "NCBIFAM" ]

[ "NF045845" ]

[ "Mhp366_Mhp367_fam" ]

[ 80 ]

1

[]

0

[]

0

[ "PUB00159674", "PUB00159675" ]

[ "19913364", "31511007" ]

[ "Characterization of a highly immunogenic Mycoplasma hyopneumoniae lipoprotein Mhp366 identified by peptide-spot array.", "Development of an indirect ELISA for detecting humoral immunodominant proteins of Mycoplasma hyopneumoniae which can discriminate between inactivated bacterin-induced hyperimmune sera and con...

[ 2010, 2019 ]

2

[]

0

null

[ "Mesomycoplasma" ]

[ 80 ]

1

[]

0

true

Family

Mhp366/Mhp367-like surface (lipo)protein

Mhp366_Mhp367-like

5

IPR060951

60,951

GapS1-like

Family

85

false

Proteins of this family are homologs of the anti-phage protein GapS1 in Vibrio parahaemolyticus.

[]

0

[ "NCBIFAM" ]

[ "NF047931" ]

[ "antiphage_GapS1" ]

[ 85 ]

1

[]

0

[]

0

[ "PUB00161243" ]

[ "39443754" ]

[ "Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools." ]

[ 2024 ]

1

[]

0

null

[ "Eukaryota", "Gegevirus ST437OXA245phi41", "Pseudomonadati" ]

[ 2, 3, 80 ]

3

[]

0

true

Family

GapS1-like

9

IPR060957

60,957

MAG6450-like

Family

76

false

Members of this uncommon protein family are found both within the Mycoplasmatota, including MAG6450 from Mycoplasmopsis agalactiae ( ) and outside of lineage. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF046006" ]

[ "MAG6450_fam" ]

[ 76 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Siphoviridae sp. ctES717", "metagenomes" ]

[ 68, 5, 1, 2 ]

4

[]

0

true

Family

MAG6450-like

8

IPR060958

60,958

His-Xaa-Ser repeat protein HxsA2

HisXaaSer_A2

Family

74

false

This entry represents a short form of the His-Xaa-Ser repeat protein HxsA, while represents a long form. In the short form, sequences average about 97 amino acids in length and end with the HXS repeat region [ ].

[]

0

[ "NCBIFAM" ]

[ "NF038296" ]

[ "HisXaaSer_A2" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00055953" ]

[ "21478363" ]

[ "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 73, 1 ]

2

[]

0

true

Family

His-Xaa-Ser repeat protein HxsA2

HisXaaSer_A2

1

IPR060959

60,959

Geobacillin-26-like

Geo26A-like

Family

73

false

This protein is homologous to geobacillin 26, a large bacteriocin (245 amino acids) that was found in the thermophile Geobacillus sp. 15, and that has an unknown mechanism of action.

[]

0

[ "NCBIFAM" ]

[ "NF035925" ]

[ "Geo26A_fam" ]

[ 73 ]

1

[]

0

[]

0

[ "PUB00105458" ]

[ "31499103" ]

[ "Geobacillin 26 - high molecular weight bacteriocin from a thermophilic bacterium." ]

[ 2019 ]

1

[]

0

null

[ "Bacillota", "Methanorbis rubei" ]

[ 72, 1 ]

2

[]

0

true

Family

Geobacillin-26-like

Geo26A-like

5

IPR060962

60,962

T4SS efffector SepA-like

T4SS_SepA-like

Family

74

false

A member of this family, BAB1_1492 from Brucella abortus ( ), was described as a novel secreted effector protein and named SepA (secreted effector protein A) [ , ]. Oddly, it is reported to aggregate in the periplasm rather than engaging immediately with the type IV secretion system (T4SS). Full length homologues are f...

[]

0

[ "NCBIFAM" ]

[ "NF047386" ]

[ "T4SS_SepA_fam" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00159577", "PUB00159578" ]

[ "26528442", "24119283" ]

[ "Type IV secretion system of Brucella spp. and its effectors.", "Identification of a type IV secretion substrate of Brucella abortus that participates in the early stages of intracellular survival." ]

[ 2015, 2014 ]

2

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 73, 1 ]

2

[]

0

true

Family

T4SS efffector SepA-like

T4SS_SepA-like

8

IPR060966

60,966

Putative phage tail protein

Tail_region

Family

68

false

Members of this family of small proteins, about 60 amino acids long, regularly are found encoded in the tail regions of apparent prophage regions of bacterial genomes.

[]

0

[ "NCBIFAM" ]

[ "NF045895" ]

[ "tail_region" ]

[ 68 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 68 ]

1

[]

0

true

Family

Putative phage tail protein

Tail_region

8

IPR060967

60,967

QWxxN domain

QWxxN_dom

Domain

72

false

The QWxxN domain is about 125 amino acids long, and appears typically as the conserved core region in up to 9 tandem repeats, each about 200 amino acids long. Proteins with this domain are known so far only in the genus Enterococcus, and may reach over 3000 amino acids in length.

[]

0

[ "NCBIFAM" ]

[ "NF033898" ]

[ "QWxxN_dom" ]

[ 72 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterococcus" ]

[ 72 ]

1

[]

0

true

Domain

QWxxN domain

QWxxN_dom

3

IPR060969

60,969

Glycopeptide resistance-associated protein GraF-like

GraF-like

Family

69

false

GraF ( ) was discovered as a small stress protein expressed at higher levels in glycopeptide (vancomycin, teicoplanin)-intermediate strains of Staphylococcus aureus. Overexperssion leads to a thicker cell wall, and reduced sensitivities to glycopeptides and oxacillin [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF038207" ]

[ "glyco_res_GraF" ]

[ 69 ]

1

[]

0

[]

0

[ "PUB00105615", "PUB00105616" ]

[ "16048954", "23554199" ]

[ "DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.", "Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages." ]

[ 2005, 2013 ]

2

[]

0

null

[ "Staphylococcus", "human gut metagenome" ]

[ 68, 1 ]

2

[]

0

true

Family

Glycopeptide resistance-associated protein GraF-like

GraF-like

8

IPR060972

60,972

Clostri-philic protein

Clostri-philic

Family

64

false

Members of this unusual, uncharacterised protein family named clostri-philic are small in size (about 45 amino acids), rich in charged residues and therefore highly hydrophilic, and largely restricted to Clostridium. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "NF040919" ]

[ "Clostri_philic" ]

[ 64 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Clostridia", "metagenomes" ]

[ 62, 2 ]

2

[]

0

true

Family

Clostri-philic protein

Clostri-philic

8

IPR060975

60,975

PFE-CTERM domain

PFE_CTERM

Domain

61

false

PFE-CTERM is a PEP-CTERM-like C-terminal short tripartite protein-sorting signal, found in cyanobacteria. PFE_CTERM domain-containing proteins often are often encoded close to cyanoexosortase A.

[]

0

[ "NCBIFAM" ]

[ "NF050011" ]

[ "PFE_CTERM" ]

[ 61 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae" ]

[ 61 ]

1

[]

0

true

Domain

PFE-CTERM domain

PFE_CTERM

4