interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR006988 | 6,988 | Nab, N-terminal | Nab_N | Domain | 2,989 | false | false | Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors [ ]. This entry represents the N-terminal NAB domain, which interacts with the EGR1 inhibitory domain (R1) [... | [
"GO:0003712",
"GO:0006355",
"GO:0005634"
] | [
"transcription coregulator activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04904"
] | [
"SAM_NCD1"
] | [
2989
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9031628",
"R-DME-9031628",
"R-HSA-9031628",
"R-HSA-9619665",
"R-MMU-9031628"
] | [
"REACTOME:R-CEL-9031628",
"REACTOME:R-DME-9031628",
"REACTOME:R-HSA-9031628",
"REACTOME:R-HSA-9619665",
"REACTOME:R-MMU-9031628"
] | 5 | [] | 0 | [
"PUB00008702"
] | [
"9418898"
] | [
"Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2989
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
3,
9,
9,
8
] | 6 | true | Domain | Nab, N-terminal | Nab, N-terminal | Nab_N | 6 |
IPR006989 | 6,989 | NAB co-repressor, domain | NAB_co-repressor_dom | Domain | 3,026 | false | false | Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors [ ]. This entry represents a NAB domain 2 of the protein. It is necessary for transcriptional repression by ... | [
"GO:0045892",
"GO:0005634"
] | [
"negative regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04905"
] | [
"NCD2"
] | [
3026
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9031628",
"R-DME-9031628",
"R-HSA-9031628",
"R-HSA-9619665",
"R-MMU-9031628"
] | [
"REACTOME:R-CEL-9031628",
"REACTOME:R-DME-9031628",
"REACTOME:R-HSA-9031628",
"REACTOME:R-HSA-9619665",
"REACTOME:R-MMU-9031628"
] | 5 | [
"2yuf"
] | 1 | [
"PUB00008702",
"PUB00008703"
] | [
"9418898",
"10734128"
] | [
"Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.",
"A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene."
] | [
1998,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3026
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
3,
6,
7,
7
] | 6 | true | Domain | NAB co-repressor, domain | NAB co-repressor, domain | NAB_co-repressor_dom | 1 |
IPR006990 | 6,990 | Tweety | Tweety | Family | 5,534 | false | false | The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C terminus. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been ide... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF04906",
"PTHR12424",
"cd07912"
] | [
"Tweety",
"",
"Tweety_N"
] | [
5217,
5439,
3183
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2672351",
"R-DME-2672351",
"R-DRE-2672351",
"R-HSA-2672351",
"R-MMU-2672351",
"R-RNO-2672351",
"R-XTR-2672351"
] | [
"REACTOME:R-CEL-2672351",
"REACTOME:R-DME-2672351",
"REACTOME:R-DRE-2672351",
"REACTOME:R-HSA-2672351",
"REACTOME:R-MMU-2672351",
"REACTOME:R-RNO-2672351",
"REACTOME:R-XTR-2672351"
] | 7 | [
"7p54",
"7p5c",
"7p5j",
"7p5m",
"7rtt",
"7rtu",
"7rtv",
"7rtw",
"9g6x",
"9g71",
"9qnr"
] | 11 | [
"PUB00008704",
"PUB00079471",
"PUB00079472",
"PUB00079473",
"PUB00079474",
"PUB00079475",
"PUB00079476",
"PUB00079477"
] | [
"10950931",
"16219661",
"18577513",
"18260827",
"17952139",
"17116230",
"15010458",
"11597145"
] | [
"Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins.",
"The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels.",
"The ubiquitin-protein ligase Nedd4-2 differentially interacts w... | [
2000,
2006,
2008,
2008,
2007,
2007,
2004,
2001
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Kluyvera intermedia"
] | [
5533,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
18,
9,
17,
7,
15
] | 6 | true | Family | Tweety | Tweety | Tweety | 2 |
IPR006994 | 6,994 | TCF25/Rqc1 | TCF25/Rqc1 | Family | 5,248 | false | false | This entry includes ribosome quality control complex subunits TCF25 from animals and Rqc1 from budding yeasts. Rqc1 is a component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradati... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04910",
"PTHR22684"
] | [
"Tcf25",
""
] | [
5056,
5097
] | 2 | [] | [] | [] | 0 | [
"9ofv"
] | 1 | [
"PUB00033388",
"PUB00090107"
] | [
"16574069",
"23178123"
] | [
"hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor.",
"A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress."
] | [
2006,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
92,
5140,
10,
6
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
2,
9,
5,
1,
2,
8,
1,
1,
3
] | 12 | true | Family | TCF25/Rqc1 | TCF25/Rqc1 | TCF25/Rqc1 | 6 |
IPR006995 | 6,995 | ATP synthase, F0 complex, subunit J | ATP_synth_F0_jsu | Family | 1,152 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0015078",
"GO:0015986",
"GO:0045259"
] | [
"proton transmembrane transporter activity",
"proton motive force-driven ATP synthesis",
"proton-transporting ATP synthase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04911",
"PTHR28060"
] | [
"ATP-synt_J",
""
] | [
1149,
1096
] | 2 | [] | [] | [] | 0 | [
"6b2z",
"6b8h",
"6cp3",
"6cp5",
"6cp6",
"6cp7",
"6wtd",
"7tjy",
"7tjz",
"7tk0",
"7tk1",
"7tk2",
"7tk3",
"7tk4",
"7tk5",
"7tk6",
"7tk7",
"7tk8",
"7tk9",
"7tka",
"7tkb",
"7tkc",
"7tkd",
"7tke",
"7tkf",
"7tkg",
"7tkh",
"7tki",
"7tkj",
"7tkk",
"7tkl",
"7tkm"... | 42 | [
"PUB00009752",
"PUB00019176",
"PUB00020603",
"PUB00020604",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"11309608",
"9867807",
"15473999",
"15078220",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.",
"ATP synthase of yeast mitochondria. Isolation of subunit j and disruption of the ATP18 gene.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ... | [
2001,
1999,
2004,
2004,
2010,
2008,
1992,
1998
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1152
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
1,
1,
1,
1
] | 4 | true | Family | ATP synthase, F0 complex, subunit J | ATP synthase, F0 complex, subunit J | ATP_synth_F0_jsu | 3 |
IPR006997 | 6,997 | Baculovirus Y142 protein | Baculo_Y142 | Family | 149 | false | false | This is a family of Baculovirus proteins including protein AC142, which is expressed in the cytoplasm and nucleus throughout infection. It is required for nucleocapsid envelopment in the budding virus to form the occlusion-derived virus and subsequent embedding of virions into polyhedra [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04913"
] | [
"Baculo_Y142"
] | [
149
] | 1 | [] | [] | [] | 0 | [
"8i8b",
"8vwi",
"8vwj",
"9h2a",
"9h2b",
"9h2j"
] | 6 | [
"PUB00082313"
] | [
"18045640"
] | [
"Autographa californica multiple nucleopolyhedrovirus ac142, a core gene that is essential for BV production and ODV envelopment."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Baculoviridae"
] | [
149
] | 1 | [] | [] | 0 | true | Family | Baculovirus Y142 protein | Baculovirus Y142 protein | Baculo_Y142 | 4 |
IPR006998 | 6,998 | DltD | DltD | Family | 2,858 | false | false | The dlt operon (dltA to dltD) of Lactobacillus rhamnosus 7469 encodes four proteins responsible for the esterification of lipoteichoic acid (LTA) by D-alanine. These esters play an important role in controlling the net anionic charge of the poly (GroP) moiety of LTA. DltA and DltC encode the D-alanine-D-alanyl carrier ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04914",
"PTHR40039"
] | [
"DltD",
""
] | [
2856,
2670
] | 2 | [
"GP"
] | [
"GenProp1398"
] | [
"GP:GenProp1398"
] | 1 | [
"3bma",
"6o93",
"6pfx",
"7dxm"
] | 4 | [
"PUB00009709"
] | [
"10781555"
] | [
"Biosynthesis of lipoteichoic acid in Lactobacillus rhamnosus: role of DltD in D-alanylation."
] | [
2000
] | 1 | [] | [
"IPR023896"
] | 0 | 1 | 0 | [
"Bacteria",
"Fungi",
"metagenomes"
] | [
2842,
4,
12
] | 3 | [] | [] | 0 | true | Family | DltD | DltD | DltD | 4 |
IPR007000 | 7,000 | Phospholipase B-like | PLipase_B-like | Family | 5,295 | false | false | Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast [ , ]. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial p... | [
"GO:0004620"
] | [
"glycerophospholipase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04916",
"PTHR12370"
] | [
"Phospholip_B",
""
] | [
5292,
5087
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.1.-",
"PWY-1921",
"PWY-5835",
"PWY-6190",
"PWY-6308",
"PWY-6322",
"PWY-6339",
"PWY-6415",
"PWY-6558",
"PWY-6848",
"PWY-7002",
"PWY-7352",
"PWY-7367",
"PWY-7521",
"PWY-7599",
"PWY-7660",
"PWY-7712",
"PWY-7713",
"PWY-7730",
"PWY-7769",
"PWY-7982",
"PWY-8058",
"PWY-8143... | [
"EC:3.1.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5835",
"METACYC:PWY-6190",
"METACYC:PWY-6308",
"METACYC:PWY-6322",
"METACYC:PWY-6339",
"METACYC:PWY-6415",
"METACYC:PWY-6558",
"METACYC:PWY-6848",
"METACYC:PWY-7002",
"METACYC:PWY-7352",
"METACYC:PWY-7367",
"METACYC:PWY-7521",
"METACYC:PWY-7... | 48 | [
"3fbx",
"3fgr",
"3fgt",
"3fgw",
"4bwc"
] | 5 | [
"PUB00019775",
"PUB00019776",
"PUB00052907"
] | [
"8892229",
"15193148",
"19706171"
] | [
"Molecular and genetic analyses of lama, an evolutionarily conserved gene expressed in the precursors of the Drosophila first optic ganglion.",
"Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast.",
"Initial insight ... | [
1996,
2004,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7,
336,
4911,
41
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
16,
2,
3,
2,
9
] | 6 | true | Family | Phospholipase B-like | Phospholipase B-like | PLipase_B-like | 8 |
IPR007001 | 7,001 | Bacterial shufflon protein, N-terminal | Shufflon_N | Domain | 2,040 | false | false | This domain represents the high-similarity N-terminal constant region shared by shufflon proteins. Shufflon proteins are created as a result of a clustered inversion region. The proteins retain a constant N-terminal domain, with different C-terminal domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04917"
] | [
"Shufflon_N"
] | [
2040
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Plasmid ColIb-P9",
"metagenomes"
] | [
2010,
4,
11,
1,
14
] | 5 | [] | [] | 0 | true | Domain | Bacterial shufflon protein, N-terminal | Bacterial shufflon protein, N-terminal | Shufflon_N | 1 |
IPR007003 | 7,003 | Protein of unknown function DUF655 | DUF655 | Family | 987 | false | false | This family includes several uncharacterised archaeal proteins including Uncharacterized protein MJ0038. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04919",
"PTHR40734"
] | [
"DUF655",
""
] | [
987,
972
] | 2 | [] | [] | [] | 0 | [
"2i5h"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
925,
3,
8,
51
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF655 | Protein of unknown function DUF655 | DUF655 | 6 |
IPR007004 | 7,004 | Beet necrotic yellow vein virus, p31 | BNYVV_p31 | Family | 146 | false | false | This is a family of hypothetical proteins known as p31, mostly from Beet necrotic yellow vein virus. P31, encoded by RNA4, is involved in efficient vector transmission, symptom severity and silencing suppression in roots [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04920"
] | [
"BNYVV_p31"
] | [
146
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076445"
] | [
"17412994"
] | [
"RNA4-encoded p31 of beet necrotic yellow vein virus is involved in efficient vector transmission, symptom severity and silencing suppression in roots."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Benyvirus"
] | [
146
] | 1 | [] | [] | 0 | true | Family | Beet necrotic yellow vein virus, p31 | Beet necrotic yellow vein virus, p31 | BNYVV_p31 | 3 |
IPR007007 | 7,007 | Ninjurin | Ninjurin | Family | 4,385 | false | false | Ninjurin (nerve injury-induced protein) proteins are transmembrane adhesion molecules involved in nerve regeneration and in various processes such as inflammation, programmed and necrotic cell death, axonal growth, cell chemotaxis and angiogenesis [ , , , ]. | [
"GO:0007155",
"GO:0042246",
"GO:0016020"
] | [
"cell adhesion",
"tissue regeneration",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04923",
"PTHR12316"
] | [
"Ninjurin",
""
] | [
4382,
4226
] | 2 | [] | [] | [] | 0 | [
"8cqr",
"8sza",
"8szb",
"8uip",
"9bia",
"9k8s",
"9k8t"
] | 7 | [
"PUB00008707",
"PUB00097893",
"PUB00097894",
"PUB00097895"
] | [
"8780658",
"31526566",
"33472215",
"31091274"
] | [
"Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.",
"Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells.",
"NINJ1 mediates plasma membrane rupture during lytic cell death.",
"Ninjurin1 regulates striated muscle gro... | [
1996,
2019,
2021,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Marseillevirus LCMAC101"
] | [
4384,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
8,
8,
8,
10
] | 5 | true | Family | Ninjurin | Ninjurin | Ninjurin | 8 |
IPR007008 | 7,008 | Poxvirus A6 | Poxvirus_A6 | Family | 143 | false | false | This entry represents Protein A6 from Vaccinia virus, also known as Virion morphogenesis protein OPG132, and similar proteins from poxvirus. A6 is a lipid-bound viral membrane assembly protein that plays an essential role in immature virion (IV) to mature virion (MV) transition [ ]. It functions in both crescent-shaped... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04924"
] | [
"Pox_A6"
] | [
143
] | 1 | [] | [] | [] | 0 | [
"6br8",
"6br9",
"6cb6",
"6cb7",
"8izt",
"8izu"
] | 6 | [
"PUB00103600",
"PUB00103601",
"PUB00103602"
] | [
"17108027",
"28275183",
"22398288"
] | [
"Vaccinia virus A6L encodes a virion core protein required for formation of mature virion.",
"Vaccinia Virus A6 Is a Two-Domain Protein Requiring a Cognate N-Terminal Domain for Full Viral Membrane Assembly Activity.",
"Vaccinia virus A6 is essential for virion membrane biogenesis and localization of virion mem... | [
2007,
2017,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Ecdysozoa",
"Poxviridae",
"Tepidibacter hydrothermalis"
] | [
2,
140,
1
] | 3 | [] | [] | 0 | true | Family | Poxvirus A6 | Poxvirus A6 | Poxvirus_A6 | 7 |
IPR007009 | 7,009 | Shq1, C-terminal domain | Shq1_C | Domain | 2,867 | false | false | This entry represents a domain found C-terminal in the yeast SHQ1 protein ( ) and related proteins. SHQ1 is involved in the early biogenesis steps of box H/ACA snoRNP assembly [ ]. The human homologue is required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably throug... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04925"
] | [
"SHQ1"
] | [
2867
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-171319",
"R-CEL-171319",
"R-DME-171319",
"R-HSA-171319",
"R-MMU-171319",
"R-SCE-171319",
"R-SPO-171319"
] | [
"REACTOME:R-BTA-171319",
"REACTOME:R-CEL-171319",
"REACTOME:R-DME-171319",
"REACTOME:R-HSA-171319",
"REACTOME:R-MMU-171319",
"REACTOME:R-SCE-171319",
"REACTOME:R-SPO-171319"
] | 7 | [
"3uah",
"3uai",
"3zuz",
"3zv0"
] | 4 | [
"PUB00011387",
"PUB00151938"
] | [
"12228251",
"19383767"
] | [
"The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis.",
"SHQ1 is required prior to NAF1 for assembly of H/ACA small nucleolar and telomerase RNPs."
] | [
2002,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonas luteola"
] | [
2866,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
2,
5,
2,
1,
1,
3,
3,
1,
1,
12
] | 10 | true | Domain | Shq1, C-terminal domain | Shq1, C-terminal domain | Shq1_C | 7 |
IPR007010 | 7,010 | Poly(A) polymerase, RNA-binding domain | PolA_pol_RNA-bd_dom | Domain | 9,653 | false | false | In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase that specifically incorporates ATP at th... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04926"
] | [
"PAP_RNA-bind"
] | [
9653
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.19",
"R-BTA-72187",
"R-BTA-72203",
"R-BTA-73856",
"R-BTA-77595",
"R-HSA-72187",
"R-HSA-72203",
"R-HSA-73856",
"R-HSA-77595",
"R-HSA-9930044",
"R-MMU-72187",
"R-MMU-72203",
"R-MMU-73856",
"R-MMU-77595",
"R-MMU-9930044"
] | [
"EC:2.7.7.19",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-72203",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-77595",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-73856",
"REACTOME:R-HSA-77595",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-72203",
"REACTOME:R... | 15 | [
"1f5a",
"1fa0",
"1q78",
"1q79",
"2hhp",
"2o1p",
"2q66",
"3c66",
"4lt6",
"7q72",
"7q73",
"7q74"
] | 12 | [
"PUB00008708"
] | [
"10944102"
] | [
"Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9653
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
17,
3,
6,
4,
14,
11,
1,
17,
12,
1,
1,
64
] | 12 | true | Domain | Poly(A) polymerase, RNA-binding domain | Poly(A) polymerase, RNA-binding domain | PolA_pol_RNA-bd_dom | 1 |
IPR007011 | 7,011 | Late embryogenesis abundant protein, SMP subgroup domain | LEA_SMP_dom | Domain | 2,752 | false | false | This entry represents Pfam SMP, or D-34 from Dure, or group 6 from Bray. LEA (late embryogenesis abundant) proteins were first identified in land plants. Plant LEA proteins have been found to accumulate to high levels during the last stage of seed formation (when a natural desiccation of the seed tissues takes place) a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04927"
] | [
"SMP"
] | [
2752
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009713",
"PUB00088595",
"PUB00088596"
] | [
"10681550",
"18318901",
"21034219"
] | [
"Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.",
"LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana.",
"LEA proteins during water stress: not just for plants anymore."
] | [
2000,
2008,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
54,
2698
] | 2 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
1,
22,
19
] | 4 | true | Domain | Late embryogenesis abundant protein, SMP subgroup domain | Late embryogenesis abundant protein, SMP subgroup domain | LEA_SMP_dom | 1 |
IPR007012 | 7,012 | Poly(A) polymerase, central domain | PolA_pol_cen_dom | Domain | 12,278 | false | false | In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase which specifically incorporates ATP at t... | [
"GO:1990817"
] | [
"poly(A) RNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04928"
] | [
"PAP_central"
] | [
12278
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.19",
"R-BTA-72187",
"R-BTA-72203",
"R-BTA-73856",
"R-BTA-77595",
"R-HSA-72187",
"R-HSA-72203",
"R-HSA-73856",
"R-HSA-77595",
"R-HSA-9930044",
"R-MMU-72187",
"R-MMU-72203",
"R-MMU-73856",
"R-MMU-77595",
"R-MMU-9930044"
] | [
"EC:2.7.7.19",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-72203",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-77595",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-73856",
"REACTOME:R-HSA-77595",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-72203",
"REACTOME:R... | 15 | [
"1f5a",
"1fa0",
"1q78",
"1q79",
"2hhp",
"2o1p",
"2q66",
"3c66",
"4lt6",
"7q72",
"7q73",
"7q74"
] | 12 | [
"PUB00008708"
] | [
"10944102"
] | [
"Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Klosneuvirinae"
] | [
249,
12026,
3
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
3,
7,
5,
13,
13,
2,
26,
13,
1,
1,
73
] | 12 | true | Domain | Poly(A) polymerase, central domain | Poly(A) polymerase, central domain | PolA_pol_cen_dom | 3 |
IPR007013 | 7,013 | DNA polymerase processivity factor, herpesviridae | DNA_pol_proc_fac_herpes | Family | 93 | false | false | Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate. The Epstein-Barr virus (strain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04929"
] | [
"Herpes_DNAp_acc"
] | [
93
] | 1 | [] | [] | [] | 0 | [
"2z0l",
"3hsl",
"3i2m"
] | 3 | [
"PUB00008710",
"PUB00009047"
] | [
"9934686",
"10882068"
] | [
"Identification of transactivator and nuclear localization domains in the Epstein-Barr virus DNA polymerase accessory protein, BMRF1.",
"The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase."
] | [
1999,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Anaeramoeba flamelloides",
"Herpesvirales"
] | [
1,
92
] | 2 | [] | [] | 0 | true | Family | DNA polymerase processivity factor, herpesviridae | DNA polymerase processivity factor, herpesviridae | DNA_pol_proc_fac_herpes | 8 |
IPR007014 | 7,014 | FUN14 | FUN14 | Family | 5,456 | false | false | This is a family of short proteins found in eukaryotes, bacteria and archaea. In humans, FUN14 domain-containing protein 1 (FUND1) acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control [ , ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04930",
"PTHR21346"
] | [
"FUN14",
""
] | [
5429,
4509
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8934903",
"R-CEL-8934903",
"R-DRE-8934903",
"R-HSA-8934903",
"R-MMU-8934903",
"R-RNO-8934903",
"R-SCE-8934903",
"R-SPO-8934903",
"R-XTR-8934903"
] | [
"REACTOME:R-BTA-8934903",
"REACTOME:R-CEL-8934903",
"REACTOME:R-DRE-8934903",
"REACTOME:R-HSA-8934903",
"REACTOME:R-MMU-8934903",
"REACTOME:R-RNO-8934903",
"REACTOME:R-SCE-8934903",
"REACTOME:R-SPO-8934903",
"REACTOME:R-XTR-8934903"
] | 9 | [] | 0 | [
"PUB00069482",
"PUB00095387"
] | [
"22267086",
"28798696"
] | [
"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.",
"Phylogenetic and Molecular Evolutionary Analysis of Mitophagy Receptors under Hypoxic Conditions."
] | [
2012,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
329,
230,
4892,
5
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
3,
4,
3,
6,
1,
19,
1,
1
] | 9 | true | Family | FUN14 | FUN14 | FUN14 | 4 |
IPR007015 | 7,015 | DNA polymerase V/Myb-binding protein 1A | DNA_pol_V/MYBBP1A | Family | 4,938 | false | false | Proteins of this family are predominantly nucleolar. Myb-binding protein 1A (MYBBP1A) is a transcription regulator that may play an important role in the cellular stress response [ , , , ]. This family also includes the fifth essential DNA polymerase (Pol5p) of Schizosaccharomyces pombe (Fission yeast) and Saccharomyce... | [
"GO:0003677",
"GO:0008134",
"GO:0006355",
"GO:0005730"
] | [
"DNA binding",
"transcription factor binding",
"regulation of DNA-templated transcription",
"nucleolus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF04931",
"PTHR13213"
] | [
"DNA_pol_phi",
""
] | [
4784,
4850
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5250924",
"R-MMU-5250924",
"R-RNO-5250924"
] | [
"REACTOME:R-HSA-5250924",
"REACTOME:R-MMU-5250924",
"REACTOME:R-RNO-5250924"
] | 3 | [] | 0 | [
"PUB00019434",
"PUB00089661",
"PUB00089662",
"PUB00089663",
"PUB00089664",
"PUB00099537",
"PUB00099538"
] | [
"12093911",
"19129230",
"12695662",
"24375404",
"11956195",
"31968688",
"31745560"
] | [
"The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA.",
"Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.",
"Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unr... | [
2002,
2009,
2003,
2014,
2002,
2020,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4938
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
3,
6,
4,
1,
4,
4,
1,
1,
10
] | 12 | true | Family | DNA polymerase V/Myb-binding protein 1A | DNA polymerase V/Myb-binding protein 1A | DNA_pol_V/MYBBP1A | 8 |
IPR007016 | 7,016 | O-antigen ligase-related domain | O-antigen_ligase-rel_domated | Domain | 47,817 | false | false | This entry represents a domain found in a group of bacterial proteins that is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in Gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL (also known as WaaL) [ ]. This entry also includes PilO ( ), which... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04932"
] | [
"Wzy_C"
] | [
47817
] | 1 | [] | [] | [] | 0 | [
"7tpg",
"7tpj"
] | 2 | [
"PUB00066761",
"PUB00086712"
] | [
"1624462",
"17890310"
] | [
"Comparison of lipopolysaccharide biosynthesis genes rfaK, rfaL, rfaY, and rfaZ of Escherichia coli K-12 and Salmonella typhimurium.",
"Functional characterization of bacterial oligosaccharyltransferases involved in O-linked protein glycosylation."
] | [
1992,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
46931,
6,
29,
153,
698
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | O-antigen ligase-related domain | O-antigen ligase-related domain | O-antigen_ligase-rel_domated | 8 |
IPR007018 | 7,018 | Mediator complex, subunit Med6 | Mediator_Med6 | Family | 4,699 | false | false | The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor... | [
"GO:0003712",
"GO:0006357",
"GO:0016592"
] | [
"transcription coregulator activity",
"regulation of transcription by RNA polymerase II",
"mediator complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04934",
"PTHR13104"
] | [
"Med6",
""
] | [
4673,
4523
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-212436",
"R-BTA-9841922",
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-BTA-212436",
"REACTOME:R-BTA-9841922",
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 8 | [
"3rj1",
"4gwp",
"4gwq",
"4h61",
"4h63",
"4v1o",
"5n9j",
"5oqm",
"5sva",
"5u0p",
"5u0s",
"6w1s",
"6xp5",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"7ui9",
"7uif",
"7uig",
"7uio",
"8cen",
"8ceo",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"... | 32 | [
"PUB00009761"
] | [
"9234719"
] | [
"A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans."
] | [
1997
] | 1 | [] | [
"IPR016612",
"IPR016820"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
4699
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
2,
1,
1,
2,
5,
4,
1,
3,
7,
1,
1,
6
] | 12 | true | Family | Mediator complex, subunit Med6 | Mediator complex, subunit Med6 | Mediator_Med6 | 5 |
IPR007019 | 7,019 | Surfeit locus 6 | SURF6 | Family | 4,266 | false | false | This entry represents the surfeit locus protein SURF6 from mammals and its homologues from plants and fungi. In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [ ]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14369"
] | [
""
] | [
4266
] | 1 | [] | [] | [] | 0 | [
"6c0f",
"8fkp",
"8fkq",
"8fkr",
"8fks",
"8i9r",
"8i9t",
"8i9v",
"8v83",
"8v84"
] | 10 | [
"PUB00008713",
"PUB00069866",
"PUB00069867",
"PUB00069868"
] | [
"9548374",
"15629442",
"17272295",
"17804645"
] | [
"The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro.",
"Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast.",
"Yeast Rrp14p is required for ribosomal subunit synthesis and for... | [
1998,
2005,
2007,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4266
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
2,
2,
1,
2,
3,
1,
2,
4,
1,
1,
2
] | 12 | true | Family | Surfeit locus 6 | Surfeit locus 6 | SURF6 | 4 |
IPR007020 | 7,020 | Protein of unknown function DUF658 | DUF658 | Family | 73 | false | false | These are proteins of unknown function found in Lactococcus lactis and in their associated bacteriophage. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04936"
] | [
"DUF658"
] | [
73
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli",
"Eukaryota",
"Viruses"
] | [
59,
3,
11
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF658 | Protein of unknown function DUF658 | DUF658 | 4 |
IPR007021 | 7,021 | Domain of unknown function DUF659 | DUF659 | Domain | 12,987 | false | false | This domain is found in eukaryotic predicted transposase-like proteins with no known specific function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04937"
] | [
"DUF659"
] | [
12987
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
12983
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
57,
53,
173
] | 3 | true | Domain | Domain of unknown function DUF659 | Domain of unknown function DUF659 | DUF659 | 5 |
IPR007023 | 7,023 | Ribosomal biogenesis regulatory protein | Ribosom_reg | Family | 4,263 | false | false | This is a family of eukaryotic ribosomal biogenesis regulatory (Rrs1) proteins. Rrs1 was isolated as a factor related to a secretory defect that caused the transcriptional repression of both rRNA and ribosomal protein genes [ ]. This protein is known to localize in the nucleolus where it acts as a ribosome assembly fac... | [
"GO:0005515",
"GO:0042254",
"GO:0005634"
] | [
"protein binding",
"ribosome biogenesis",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04939"
] | [
"RRS1"
] | [
4263
] | 1 | [] | [] | [] | 0 | [
"3jct",
"4xd9",
"5a53",
"5by8",
"5wxl",
"6ft6",
"6m62",
"7bt6",
"7btb",
"7oh3",
"7ohq",
"7oht",
"7ozs",
"7ug6",
"7uoo",
"7uqb",
"7uqz",
"7v08",
"8fkp",
"8fkq",
"8fkr",
"8fks",
"8fkt",
"8fku",
"8fkv",
"8fkw",
"8fkx",
"8fky",
"8fl0",
"8i9r",
"8ir1",
"8ir3"... | 42 | [
"PUB00103786",
"PUB00103787",
"PUB00103788",
"PUB00103789"
] | [
"10688653",
"6117542",
"26117542",
"21822217"
] | [
"RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.",
"The enzyme cytochemistry of the intracellular organelles in the rat choroid plexus epithelial cell.",
"The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis.",
"... | [
2000,
1981,
2015,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4263
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
9,
1,
2,
1,
2,
2,
1,
1,
21
] | 12 | true | Family | Ribosomal biogenesis regulatory protein | Ribosomal biogenesis regulatory protein | Ribosom_reg | 4 |
IPR007024 | 7,024 | BLUF domain | BLUF_domain | Domain | 7,348 | false | false | The BLUF domain (named for sensors of Blue-Light Using FAD) is an FAD-binding protein domain. BLUF domains are present in various proteins, primarily from bacteria. For example a BLUF domain is found at the N terminus of the AppA protein from Rhodobacter sphaeroides [ ]. BLUF domains are involved in sensing blue-light ... | [
"GO:0009882",
"GO:0071949"
] | [
"blue light photoreceptor activity",
"FAD binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF04940",
"PS50925",
"SM01034"
] | [
"BLUF",
"BLUF",
"BLUF"
] | [
6993,
7079,
7187
] | 3 | [
"PROSITEDOC"
] | [
"PDOC50925"
] | [
"PROSITEDOC:PDOC50925"
] | 1 | [
"1x0p",
"1yrx",
"2bun",
"2byc",
"2hfn",
"2hfo",
"2iyg",
"2iyi",
"2kb2",
"3gfx",
"3gfy",
"3gfz",
"3gg0",
"3gg1",
"3mzi",
"4hh0",
"4hh1",
"4yus",
"4yut",
"5m27",
"5m2a",
"5mbb",
"5mbc",
"5mbd",
"5mbe",
"5mbh",
"5mbj",
"5mbk",
"5nby",
"5x4t",
"5x4u",
"5x4v"... | 46 | [
"PUB00009762",
"PUB00039766"
] | [
"12368079",
"16323221"
] | [
"BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms.",
"The solution structure of the AppA BLUF domain: insight into the mechanism of light-induced signaling."
] | [
2002,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6799,
504,
45
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | BLUF domain | BLUF domain | BLUF_domain | 8 |
IPR007025 | 7,025 | Late expression factor 8 (LEF-8) | LEF-8 | Family | 581 | false | false | Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to the second largest subunit of prokaryotic DNA-directed RNA polymerase [ ]. | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04941"
] | [
"LEF-8"
] | [
581
] | 1 | [
"EC"
] | [
"2.7.7.6"
] | [
"EC:2.7.7.6"
] | 1 | [] | 0 | [
"PUB00008715"
] | [
"12124466"
] | [
"Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Baculoviridae"
] | [
581
] | 1 | [] | [] | 0 | true | Family | Late expression factor 8 (LEF-8) | Late expression factor 8 (LEF-8) | LEF-8 | 1 |
IPR007026 | 7,026 | CC domain | CC_domain | Domain | 365 | false | false | This short domain contains four conserved cysteines that are probably required for the formation of two disulphide bonds. The domain is found in Chtb-1 from Caenorhabditis elegans and similar nematode proteins. The domain is named after the characteristic CC motif. Chitin binding domain (ChtBD2) containing chtb-1 (chtb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04942"
] | [
"CC"
] | [
365
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
3,
362
] | 2 | [
"Caenorhabditis elegans"
] | [
15
] | 1 | true | Domain | CC domain | CC domain | CC_domain | 9 |
IPR007027 | 7,027 | Poxvirus F11 | Poxvirus_F11 | Family | 150 | false | false | This entry represents the poxvirus Protein F11 from Vaccinia virus, also known as Protein OPG055, and similar sequences from poxvirus. They are early virus proteins. F11 stimulates increases in peripheral microtubule dynamics and may increase the motility of the infected cells, contributing to cell-to-cell spread of th... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04943",
"PIRSF015981"
] | [
"Pox_F11",
"VAC_F11L"
] | [
150,
93
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103603",
"PUB00103604"
] | [
"18005700",
"18485055"
] | [
"F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during vaccinia virus infection.",
"The vaccinia virus F11L gene product facilitates cell detachment and promotes migration."
] | [
2007,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
150
] | 1 | [] | [] | 0 | true | Family | Poxvirus F11 | Poxvirus F11 | Poxvirus_F11 | 3 |
IPR007031 | 7,031 | Poxvirus VLTF3, late transcription factor | Poxvirus_VLTF3 | Family | 728 | false | false | Members of this family are approximately 26kDa, and are involved in trans-activation of late transcription [ ]. | [
"GO:0046782"
] | [
"regulation of viral transcription"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04947"
] | [
"Pox_VLTF3"
] | [
728
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008716"
] | [
"8523544"
] | [
"The A2L intermediate gene product is required for in vitro transcription from a vaccinia virus late promoter."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses",
"metagenomes"
] | [
58,
383,
287
] | 3 | [] | [] | 0 | true | Family | Poxvirus VLTF3, late transcription factor | Poxvirus VLTF3, late transcription factor | Poxvirus_VLTF3 | 7 |
IPR007032 | 7,032 | Poxvirus A51 | Poxvirus_A51 | Family | 144 | false | false | This entry represents Vaccinia virus A51, also known as Protein OPG181, and its homologues from poxvirus. This protein associates with ubiquitin and stabilises host microtubules, promotes viral protein stability, and plays an essential role in viral replication in vertebrate cells [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04948"
] | [
"Pox_A51"
] | [
144
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103610",
"PUB00103611"
] | [
"36366490",
"24966209"
] | [
"ORF-Interrupting Mutations in Monkeypox Virus Genomes from Washington and Ohio, 2022.",
"A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection."
] | [
2022,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae",
"Parabacteroides distasonis"
] | [
143,
1
] | 2 | [] | [] | 0 | true | Family | Poxvirus A51 | Poxvirus A51 | Poxvirus_A51 | 6 |
IPR007033 | 7,033 | RAB6-interacting golgin | GORAB | Family | 3,326 | false | false | This entry represents RAB6-interacting golgin, including SCYL1BP1 (also known as GORAB) from humans. SCYL1BP1 localises to the Golgi apparatus and interacts with Rab6 [ , ]. Therefore, SCYL1BP1 is identified as a golgin, a protein that tether vesicles to the Golgi apparatus. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04949",
"PTHR21470"
] | [
"Transcrip_act",
""
] | [
2866,
3054
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066760",
"PUB00075445",
"PUB00075446"
] | [
"21457711",
"18997784",
"26000619"
] | [
"TaSRG, a wheat transcription factor, significantly affects salt tolerance in transgenic rice and Arabidopsis.",
"Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.",
"GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting."
] | [
2011,
2008,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3326
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
35,
5,
1,
3,
1,
6,
2,
8
] | 8 | true | Family | RAB6-interacting golgin | RAB6-interacting golgin | GORAB | 1 |
IPR007034 | 7,034 | Ribosome biogenesis protein BMS1/TSR1, C-terminal | BMS1_TSR1_C | Domain | 11,083 | false | false | This domain is found at the C terminus of the ribosome biogenesis protein BMS1 and TSR1 families, which may act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF04950",
"SM01362"
] | [
"RIBIOP_C",
"DUF663"
] | [
11079,
10818
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 5 | [
"5iw7",
"5jpq",
"5oql",
"5wlc",
"5wwn",
"5wyj",
"5wyk",
"6eml",
"6fai",
"6g18",
"6g4s",
"6g4w",
"6g51",
"6g53",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rbd",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6wdr",
"6y7c",
"6zmt"... | 84 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11083
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
2,
3,
2,
3,
5,
2,
7,
9,
2,
2,
34
] | 12 | true | Domain | Ribosome biogenesis protein BMS1/TSR1, C-terminal | Ribosome biogenesis protein BMS1/TSR1, C-terminal | BMS1_TSR1_C | 4 |
IPR007035 | 7,035 | Peptidase M55, D-aminopeptidase | Peptidase_M55 | Family | 4,738 | false | false | Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04951",
"PIRSF015853"
] | [
"Peptidase_M55",
"Pep_DppA"
] | [
4738,
4311
] | 2 | [] | [] | [] | 0 | [
"1hi9"
] | 1 | [
"PUB00003579",
"PUB00008717"
] | [
"7674922",
"11473256"
] | [
"Evolutionary families of metallopeptidases.",
"Structure of the Bacillus subtilis D-aminopeptidase DppA reveals a novel self-compartmentalizing protease."
] | [
1995,
2001
] | 2 | [] | [
"IPR033824"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
117,
4485,
5,
131
] | 4 | [] | [] | 0 | true | Family | Peptidase M55, D-aminopeptidase | Peptidase M55, D-aminopeptidase | Peptidase_M55 | 9 |
IPR007036 | 7,036 | AstE/AspA barrel-sandwich hybrid domain | Aste_AspA_hybrid_dom | Domain | 6,657 | false | false | This entry represents the barrel-sandwich hybrid domain found in Succinylglutamate desuccinylase (AstE), aspartoacylase (AspA) and related enzymes. AstE catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway whereas AspA cleaves acylaspartate into a fatty acid and aspartate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04952"
] | [
"AstE_AspA_hybrid"
] | [
6657
] | 1 | [
"EC",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1",
"3.5.1.96",
"GenProp1280",
"R-DRE-5423646",
"R-DRE-8963693",
"R-HSA-5423646",
"R-HSA-8963693",
"R-MMU-5423646",
"R-MMU-8963693",
"R-RNO-5423646",
"R-RNO-8963693",
"R-XTR-5423646",
"R-XTR-8963693"
] | [
"EC:3.5.1",
"EC:3.5.1.96",
"GP:GenProp1280",
"REACTOME:R-DRE-5423646",
"REACTOME:R-DRE-8963693",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-8963693",
"REACTOME:R-MMU-5423646",
"REACTOME:R-MMU-8963693",
"REACTOME:R-RNO-5423646",
"REACTOME:R-RNO-8963693",
"REACTOME:R-XTR-5423646",
"REACTOME:R-X... | 13 | [
"1yw4",
"1yw6",
"2bco",
"2g9d",
"2gu2",
"2i3c",
"2o4h",
"2o53",
"2q4z",
"2q51",
"3nfz",
"3nh4",
"3nh5",
"3nh8",
"4mri",
"4mxu",
"4nfr",
"4tnu"
] | 18 | [
"PUB00008718",
"PUB00065416"
] | [
"8252036",
"20921362"
] | [
"Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.",
"Structures of aminoacylase 3 in complex with acetylated substrates."
] | [
1993,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4903,
1748,
6
] | 3 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
4,
2,
6
] | 5 | true | Domain | AstE/AspA barrel-sandwich hybrid domain | AstE/AspA barrel-sandwich hybrid domain | Aste_AspA_hybrid_dom | 5 |
IPR007037 | 7,037 | SIP-like, Rossmann fold domain | SIP_rossman_dom | Domain | 20,018 | false | false | This entry represents the domain found C-terminal in SIPs, mostly found in gram-negative bacteria such as which could belong to SIP subgroup I. This domain has a three-layer αβα architecture with a Rossmann fold topology [ ]. This entry also includes Mycobactin import ATP-binding/permease protein IrtA, where this domai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04954"
] | [
"SIP"
] | [
20018
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1222449",
"R-HSA-9638334"
] | [
"REACTOME:R-HSA-1222449",
"REACTOME:R-HSA-9638334"
] | 2 | [
"2gpj",
"4yhb",
"6geh",
"6k2l",
"6tej",
"6tek",
"7lrn",
"7wiu",
"7wiv",
"7wiw",
"7wix",
"7xlz",
"8c4l",
"9fxc",
"9g2k",
"9g2l",
"9g2m"
] | 17 | [
"PUB00160336",
"PUB00160337",
"PUB00160338"
] | [
"34308084",
"19948799",
"32296173"
] | [
"Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from <i>Acinetobacter baumannii</i>.",
"The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain.",
"The ABC exporter IrtAB imports and reduces mycobacterial siderophores.... | [
2021,
2010,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
19955,
14,
49
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | SIP-like, Rossmann fold domain | SIP-like, Rossmann fold domain | SIP_rossman_dom | 3 |
IPR007038 | 7,038 | Hydrogenase/Urease accessory protein HupE/UreJ protein | HupE_UreJ | Family | 4,723 | false | false | This family of proteins are hydrogenase/urease accessory proteins. R. leguminosarum HupE is a transmembrane nickel permease that may be required for hydrogen uptake [ ]. UreJ is a transmembrane protein shareing homology with HupE. Its function is not clear [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04955",
"PIRSF016919"
] | [
"HupE_UreJ",
"HupE_UreJ"
] | [
4723,
4005
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013611",
"PUB00063674"
] | [
"9524276",
"20023036"
] | [
"Characterisation of the urease gene cluster in Bordetella bronchiseptica.",
"Rhizobium leguminosarum hupE encodes a nickel transporter required for hydrogenase activity."
] | [
1998,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4694,
2,
27
] | 3 | [] | [] | 0 | true | Family | Hydrogenase/Urease accessory protein HupE/UreJ protein | Hydrogenase/Urease accessory protein HupE/UreJ protein | HupE_UreJ | 9 |
IPR007039 | 7,039 | Conjugal transfer TrbC/type IV secretion VirB2 | TrbC/VirB2 | Family | 8,181 | false | false | Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure[ ]. This family also contains several VirB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04956"
] | [
"TrbC"
] | [
8181
] | 1 | [
"GP"
] | [
"GenProp0485"
] | [
"GP:GenProp0485"
] | 1 | [
"8cue",
"8cw4",
"8exh",
"8fai",
"8s6h"
] | 5 | [
"PUB00008719",
"PUB00012917"
] | [
"12160637",
"12421311"
] | [
"Tying rings for sex.",
"The VirB/VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection."
] | [
2002,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"plasmids",
"uncultured Caudovirales phage"
] | [
10,
8072,
39,
47,
12,
1
] | 6 | [] | [] | 0 | true | Family | Conjugal transfer TrbC/type IV secretion VirB2 | Conjugal transfer TrbC/type IV secretion VirB2 | TrbC/VirB2 | 4 |
IPR007041 | 7,041 | Arginine N-succinyltransferase AstA/AruG | Arg_succinylTrfase_AstA/AruG | Family | 7,506 | false | false | Arginine N-succinyltransferase catalyses the transfer of succinyl-CoA to arginine to produce succinylarginine. This is the first step in arginine catabolism via the arginine succinyltransferase pathway. Six major L-arginine-degrading pathways have been described for prokaryotes [ ]. Arginine succinyltransferase AstA ( ... | [
"GO:0008791",
"GO:0006527"
] | [
"arginine N-succinyltransferase activity",
"L-arginine catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"NCBIFAM"
] | [
"MF_01171",
"PF04958",
"TIGR03243"
] | [
"AstA",
"AstA",
"arg_catab_AOST"
] | [
1089,
7506,
7136
] | 3 | [
"EC",
"GP"
] | [
"2.3.1.109",
"GenProp1280"
] | [
"EC:2.3.1.109",
"GP:GenProp1280"
] | 2 | [
"1yle"
] | 1 | [
"PUB00008006",
"PUB00043076",
"PUB00043524"
] | [
"9696779",
"9393691",
"18045455"
] | [
"Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.",
"Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.",
"Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacter... | [
1998,
1997,
2007
] | 3 | [] | [
"IPR017650",
"IPR017651"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7473,
5,
28
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Arginine N-succinyltransferase AstA/AruG | Arginine N-succinyltransferase AstA/AruG | Arg_succinylTrfase_AstA/AruG | 1 |
IPR007042 | 7,042 | SERRATE/Ars2 , C-terminal | SERRATE/Ars2_C | Domain | 5,308 | false | false | This domain can be found in the C terminus of the SERRATE (SE) from plants and its homologue, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04959"
] | [
"ARS2"
] | [
5308
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6807505",
"R-BTA-72163",
"R-BTA-9930044",
"R-CEL-6807505",
"R-CEL-72163",
"R-CEL-9930044",
"R-DME-6807505",
"R-DME-72163",
"R-DME-9930044",
"R-DRE-6807505",
"R-DRE-72163",
"R-HSA-6807505",
"R-HSA-72163",
"R-HSA-9930044",
"R-MMU-6807505",
"R-MMU-72163",
"R-MMU-9930044",
"R-SP... | [
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-9930044",
"REACTOME:R-CEL-6807505",
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-9930044",
"REACTOME:R-DME-6807505",
"REACTOME:R-DME-72163",
"REACTOME:R-DME-9930044",
"REACTOME:R-DRE-6807505",
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-... | 18 | [
"3ax1",
"6f7j",
"6f7p",
"6f7s",
"6f8d",
"7qy5",
"8pmp"
] | 7 | [
"PUB00090022"
] | [
"29703953"
] | [
"Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5308
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
3,
1,
2,
3,
4,
3,
1,
8,
1,
1,
27
] | 11 | true | Domain | SERRATE/Ars2 , C-terminal | SERRATE/Ars2 , C-terminal | SERRATE/Ars2_C | 6 |
IPR007044 | 7,044 | Cyclodeaminase/cyclohydrolase | Cyclodeamin/CycHdrlase | Domain | 5,746 | false | false | Enzymes containing the cyclodeaminase domain function in channelling one-carbon units to the folate pool. In most cases, this domain catalyses the cyclisation of formimidoyltetrahydrofolate to methenyltetrahydrofolate as shown in reaction (1). In the methylotrophic bacterium Methylobacterium extorquens, however, it cat... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04961"
] | [
"FTCD_C"
] | [
5746
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.2.5",
"4.3.1.4",
"PWY-5030",
"PWY-5497",
"R-DDI-70921",
"R-HSA-70921",
"R-MMU-70921",
"R-RNO-70921"
] | [
"EC:2.1.2.5",
"EC:4.3.1.4",
"METACYC:PWY-5030",
"METACYC:PWY-5497",
"REACTOME:R-DDI-70921",
"REACTOME:R-HSA-70921",
"REACTOME:R-MMU-70921",
"REACTOME:R-RNO-70921"
] | 8 | [
"1o5h",
"1tt9",
"2pfd",
"7vg4",
"7vg5"
] | 5 | [
"PUB00019582",
"PUB00020619",
"PUB00020620",
"PUB00020989"
] | [
"7654689",
"10215859",
"7410436",
"15651027"
] | [
"The two monofunctional domains of octameric formiminotransferase-cyclodeaminase exist as dimers.",
"A methenyl tetrahydromethanopterin cyclohydrolase and a methenyl tetrahydrofolate cyclohydrolase in Methylobacterium extorquens AM1.",
"The bifunctional enzyme formiminotransferase-cyclodeaminase is a tetramer o... | [
1995,
1999,
1980,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
102,
4089,
1413,
142
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
1,
4
] | 4 | true | Domain | Cyclodeaminase/cyclohydrolase | Cyclodeaminase/cyclohydrolase | Cyclodeamin/CycHdrlase | 8 |
IPR007045 | 7,045 | 5-keto 4-deoxyuronate isomerase | KduI | Family | 6,648 | false | false | This family of bacterial proteins have been characterised as 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase. It is coded for by kdul [ ] and is involved in the fourth step in pectin degradation. 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate Although this enzyme is found in Escherich... | [
"GO:0008697",
"GO:0045490"
] | [
"4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity",
"pectin catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PIRSF",
"PANTHER"
] | [
"MF_00687",
"NF002091",
"PIRSF006625",
"PTHR38461"
] | [
"KduI",
"PRK00924.1",
"KduI",
""
] | [
6140,
6475,
5968,
6648
] | 4 | [
"EC",
"METACYC"
] | [
"5.3.1.17",
"PWY-6507"
] | [
"EC:5.3.1.17",
"METACYC:PWY-6507"
] | 2 | [
"1x8m",
"1xru",
"1ywk",
"7e4s",
"7vgk",
"7ye3",
"7yrs",
"9kcz",
"9kd0"
] | 9 | [
"PUB00014561",
"PUB00038353",
"PUB00043775",
"PUB00093668",
"PUB00159454",
"PUB00159455"
] | [
"1766386",
"16152643",
"9761873",
"31285597",
"23437267",
"17322190"
] | [
"Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation.",
"The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli.",
"Crystallization of 5-keto-4-deoxyuronate isomerase from Escherichia coli.",
"A marine bacterial enzymatic cascade degrades the algal polysacch... | [
1991,
2005,
1998,
2019,
2013,
2007
] | 6 | [
"IPR021120"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured marine thaumarchaeote AD1000_14_F02"
] | [
6592,
8,
47,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 5-keto 4-deoxyuronate isomerase | 5-keto 4-deoxyuronate isomerase | KduI | 3 |
IPR007046 | 7,046 | RNA polymerase sigma factor 54, core-binding domain | RNA_pol_sigma_54_core-bd | Domain | 17,257 | false | false | Bacterial core RNA polymerases (with subunit composition alpha2-β-β') must combine with a sigma subunit to transcribe from specific DNA promoter sequences. This domain, the core-binding domain of sigma factor 54, is a four-helical domain with negative charge that binds and makes a direct interaction with the core RNA p... | [
"GO:0003677",
"GO:0006352"
] | [
"DNA binding",
"DNA-templated transcription initiation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04963"
] | [
"Sigma54_CBD"
] | [
17257
] | 1 | [] | [] | [] | 0 | [
"2k9l",
"2k9m",
"5nsr",
"5nss",
"5nwt",
"5ui5",
"5ui8",
"6gfw",
"6gh5",
"6gh6",
"7qv9",
"7qwp",
"7qxi",
"8f1i",
"8f1j",
"8f1k",
"8re4",
"8rea",
"9mse",
"9msf",
"9msg",
"9msh",
"9msj",
"9q90",
"9q91",
"9q92",
"9q93",
"9q94",
"9q95",
"9q96",
"9q97",
"9q98"... | 32 | [
"PUB00008721",
"PUB00048281"
] | [
"10894718",
"19426742"
] | [
"The bacterial enhancer-dependent sigma(54) (sigma(N)) transcription factor.",
"Structure of the RNA polymerase core-binding domain of sigma(54) reveals a likely conformational fracture point."
] | [
2000,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote AD1000_06_A03"
] | [
16946,
29,
281,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | RNA polymerase sigma factor 54, core-binding domain | RNA polymerase sigma factor 54, core-binding domain | RNA_pol_sigma_54_core-bd | 2 |
IPR007047 | 7,047 | Flp/Fap pilin component | Flp_Fap | Family | 8,590 | false | false | This entry is for the fimbriae associated protein Flp/Fap pilin component. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04964"
] | [
"Flp_Fap"
] | [
8590
] | 1 | [] | [] | [] | 0 | [
"8u1k",
"8u2b",
"8ucr"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8475,
7,
108
] | 3 | [] | [] | 0 | true | Family | Flp/Fap pilin component | Flp/Fap pilin component | Flp_Fap | 9 |
IPR007048 | 7,048 | IraD/Gp25-like | IraD/Gp25-like | Domain | 17,853 | false | false | This domain is found in baseplate protein Gp25 from phage T4 and related phages, and Gp25-like proteins from bacteria [ , ]. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerisation, playing a critical role in sheath assembly and contraction [ , ]. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04965"
] | [
"GPW_gp25"
] | [
17853
] | 1 | [] | [] | [] | 0 | [
"2ia7",
"5iv5",
"5iv7",
"5iw9",
"6gj1",
"6j0n",
"6od1",
"6rao",
"6u5b",
"6u5k",
"7aeb",
"7aef",
"7b5h",
"9f4a",
"9f4b",
"9gtp",
"9qgl"
] | 17 | [
"PUB00033857",
"PUB00068874",
"PUB00084196",
"PUB00091112",
"PUB00097484"
] | [
"3520236",
"21639793",
"27193680",
"21873404",
"30905475"
] | [
"Identification of T4 gene 25 product, a component of the tail baseplate, as a 15K lysozyme.",
"The RpoS-mediated general stress response in Escherichia coli.",
"Structure of the T4 baseplate and its function in triggering sheath contraction.",
"Structure-function analysis of HsiF, a gp25-like component of th... | [
1986,
2011,
2016,
2011,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
57,
16840,
22,
809,
125
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | IraD/Gp25-like | IraD/Gp25-like | IraD/Gp25-like | 4 |
IPR007049 | 7,049 | Carbohydrate-selective porin OprB | Carb-sel_porin_OprB | Family | 10,943 | false | false | The carbohydrate-selective porin OprB family includes the Pseudomonas aeruginosa porin B, a substrate-selective channel for a variety of different sugars. This protein may facilitate diffusion of a variety of diverse compounds, but is probably restricted to carbohydrates, and does facilitate glucose fusion across the o... | [
"GO:0015288",
"GO:0008643",
"GO:0016020"
] | [
"porin activity",
"carbohydrate transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04966"
] | [
"OprB"
] | [
10943
] | 1 | [] | [] | [] | 0 | [
"4gey",
"4gf4"
] | 2 | [] | [] | [] | [] | 0 | [] | [
"IPR047684"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Synechococcus phage S-SRM01",
"unclassified sequences"
] | [
10844,
19,
1,
79
] | 4 | [] | [] | 0 | true | Family | Carbohydrate-selective porin OprB | Carbohydrate-selective porin OprB | Carb-sel_porin_OprB | 8 |
IPR007050 | 7,050 | Bacterioopsin activator-type, HTH domain | HTH_bacterioopsin | Domain | 10,722 | false | false | Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. This entry represents the HTH DNA binding domain found in bacterioopsin transcriptional activator from Halobacterium salinarium (Halobacterium halobium) [ , ] and other proteins, mainly from Halobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04967"
] | [
"HTH_10"
] | [
10722
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00058190",
"PUB00058191"
] | [
"8202511",
"2459111"
] | [
"The bat gene of Halobacterium halobium encodes a trans-acting oxygen inducibility factor.",
"Transcription of genes involved in bacterio-opsin gene expression in mutants of a halophilic archaebacterium."
] | [
1994,
1988
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"metagenomes",
"uncultured Caudovirales phage"
] | [
10630,
17,
11,
63,
1
] | 5 | [] | [] | 0 | true | Domain | Bacterioopsin activator-type, HTH domain | Bacterioopsin activator-type, HTH domain | HTH_bacterioopsin | 2 |
IPR007051 | 7,051 | CHORD domain | CHORD_dom | Domain | 5,780 | false | false | Cysteine- and histidine-rich domains (CHORDs) are 60-amino acid modules that bind two zinc ions. They are usually arranged in tandem and are found in all tested eukaryotes, with the exception of yeast, where they are involved in processes ranging from pressure sensing in the heart to maintenance of diploidy in fungi, a... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF04968",
"PS51401"
] | [
"CHORD",
"CHORD"
] | [
5776,
5699
] | 2 | [] | [] | [] | 0 | [
"2xcm",
"2yrt"
] | 2 | [
"PUB00008722",
"PUB00052587"
] | [
"10571178",
"17279625"
] | [
"A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.",
"Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules."
] | [
1999,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5780
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
1,
4,
1,
7,
6,
1,
3,
4,
9
] | 10 | true | Domain | CHORD domain | CHORD domain | CHORD_dom | 8 |
IPR007052 | 7,052 | CS domain | CS_dom | Domain | 48,897 | false | false | The bipartite CS domain, which was named after CHORD-containing proteins and SGT1 [ ], is a ~100-residue protein-protein interaction module. The CS domain can be found in stand-alone form, as well as fused with other domains, such as CHORD ( ), SGS ( ), TPR ( ), cytochrome b5 ( ) or b5 reductase, in multidomain protein... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF04969",
"PS51203"
] | [
"CS",
"CS"
] | [
36943,
48184
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51203",
"R-BTA-1237044",
"R-BTA-141444",
"R-BTA-171319",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-5663220",
"R-BTA-68877",
"R-BTA-75876",
"R-BTA-844456",
"R-BTA-9648025",
"R-BTA-9696270",
"R-CEL-2162123",
"R-CEL-3371511",
"R-CEL-8937144",
"R-DDI-844456",
"R-DDI-9648025",
"R-DM... | [
"PROSITEDOC:PDOC51203",
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-171319",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-5663220",
"REACTOME:R-BTA-68877",
"REACTOME:R-BTA-75876",
"REACTOME:R-BTA-844456",
"REACTOME:R-BTA-9648025",
"REACTOME:R-BTA-9... | 96 | [
"1ejf",
"1rl1",
"1wfi",
"1wgv",
"1wh0",
"1x5m",
"2cg9",
"2cr0",
"2h50",
"2h53",
"2jki",
"2k8q",
"2kmw",
"2mnw",
"2o30",
"2rh0",
"2xcm",
"3eud",
"3qor",
"4pbd",
"4pck",
"4rzk",
"6k7w",
"6khv",
"6mv1",
"6mv2",
"7krj",
"7l7i",
"7l7j",
"7y04",
"8h77"
] | 31 | [
"PUB00008722",
"PUB00021038",
"PUB00033716"
] | [
"10571178",
"14761955",
"12372593"
] | [
"A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.",
"Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain.",
"p23 and HSP20/alpha-crystallin proteins define a conserved sequence dom... | [
1999,
2004,
2002
] | 3 | [] | [
"IPR037893",
"IPR037894",
"IPR037902",
"IPR037905",
"IPR037908",
"IPR048696"
] | 0 | 6 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
528,
1804,
46503,
3,
59
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
45,
5,
44,
14,
61,
38,
5,
33,
66,
3,
4,
87
] | 12 | true | Domain | CS domain | CS domain | CS_dom | 8 |
IPR007053 | 7,053 | LRAT domain | LRAT_dom | Domain | 14,397 | false | false | This domain (LRAT domain) is found in a variety of proteins, including lecithin retinol acyltransferase (LRAT), HRAS-like suppressors (HRASLS1-5) and proteins FAM84A and FAM84B. Acyltransferase LRAT is the main enzyme that catalyzes vitamin A esterification [ ]. HRASLS enzymes are also referred to as LRAT-like proteins... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF04970",
"PS51934"
] | [
"LRAT",
"LRAT"
] | [
13954,
13611
] | 2 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1703",
"R-DRE-1482839",
"R-HSA-1482788",
"R-HSA-1482801",
"R-HSA-1482839",
"R-HSA-1482922",
"R-HSA-2453902",
"R-HSA-975634",
"R-HSA-9918442",
"R-MMU-1482788",
"R-MMU-1482801",
"R-MMU-1482839",
"R-MMU-1482922",
"R-MMU-2453902",
"R-MMU-975634",
"R-RNO-1482788",
"R-RNO-1482801",... | [
"GP:GenProp1703",
"REACTOME:R-DRE-1482839",
"REACTOME:R-HSA-1482788",
"REACTOME:R-HSA-1482801",
"REACTOME:R-HSA-1482839",
"REACTOME:R-HSA-1482922",
"REACTOME:R-HSA-2453902",
"REACTOME:R-HSA-975634",
"REACTOME:R-HSA-9918442",
"REACTOME:R-MMU-1482788",
"REACTOME:R-MMU-1482801",
"REACTOME:R-MMU-1... | 21 | [
"2kyt",
"2lkt",
"2my9",
"4dot",
"4dpz",
"4fa0",
"4q95",
"7c3z",
"7zom",
"7zot",
"7ztw",
"7zu3",
"7zu4",
"7zua",
"7zuo",
"7zv1",
"7zv6",
"8a2e",
"8a2f"
] | 19 | [
"PUB00061229",
"PUB00065877",
"PUB00091723",
"PUB00097553"
] | [
"22605381",
"22923616",
"16174770",
"25871522"
] | [
"Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins.",
"Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad.",
"Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A defi... | [
2012,
2012,
2005,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1577,
12462,
348,
10
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
22,
1,
29,
16,
12,
14,
17,
25
] | 8 | true | Domain | LRAT domain | LRAT domain | LRAT_dom | 7 |
IPR007054 | 7,054 | Lysis protein S | Lysis_S | Family | 1,238 | false | false | This entry contains a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the ... | [
"GO:0140911",
"GO:0001907"
] | [
"pore-forming activity",
"symbiont-mediated killing of host cell"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF"
] | [
"PF04971",
"PIRSF030786"
] | [
"Phage_holin_2_1",
"Lysis_S"
] | [
1237,
856
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008724",
"PUB00084995"
] | [
"8467992",
"17827300"
] | [
"Non-specific hole formation in the Escherichia coli inner membrane by lambda S proteins in independent of cellular secY and secA functions and of the proportion of membrane acidic phospholipids.",
"The pinholin of lambdoid phage 21: control of lysis by membrane depolarization."
] | [
1993,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
1052,
186
] | 2 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Lysis protein S | Lysis protein S | Lysis_S | 2 |
IPR007055 | 7,055 | BON domain | BON_dom | Domain | 36,282 | false | false | The BON domain is typically ~60 residues long and has an α/β fold. There is a conserved glycine residue and several hydrophobic regions which suggests a binding function, and, actually, it contains a phospholipid-binding site , ]. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF04972",
"PS50914"
] | [
"BON",
"BON"
] | [
35445,
33412
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50914"
] | [
"PROSITEDOC:PDOC50914"
] | 1 | [
"2kgs",
"2ksm",
"2l26",
"4qo6",
"4qq0",
"6v4v",
"6xmv",
"7a2d",
"7pvc",
"7vcm",
"8rjx",
"8zex"
] | 12 | [
"PUB00011888",
"PUB00101371",
"PUB00101372",
"PUB00101373",
"PUB00101374"
] | [
"12878000",
"33315009",
"33847565",
"27112601",
"22206986"
] | [
"The BON domain: a putative membrane-binding domain.",
"Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation.",
"Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress.",
"The Pota... | [
2003,
2020,
2021,
2016,
2012
] | 5 | [] | [
"IPR014004"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9,
35965,
54,
254
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | BON domain | BON domain | BON_dom | 8 |
IPR007059 | 7,059 | DMSO reductase anchor subunit (DmsC) | DmsC | Family | 7,618 | false | false | The terminal electron transfer enzyme dimethyl sulphoxide reductase of Escherichia coli is a heterotrimeric enzyme composed of a membrane extrinsic catalytic dimer (DmsAB) and a membrane intrinsic polytopic anchor subunit (DmsC) [ ]. This family represents DmsC. | [
"GO:0019645",
"GO:0016020"
] | [
"anaerobic electron transport chain",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04976",
"PTHR38095"
] | [
"DmsC",
""
] | [
7585,
7074
] | 2 | [
"GP",
"GP"
] | [
"GenProp0637",
"GenProp1148"
] | [
"GP:GenProp0637",
"GP:GenProp1148"
] | 2 | [] | 0 | [
"PUB00008727"
] | [
"8429002"
] | [
"The topology of the anchor subunit of dimethyl sulfoxide reductase of Escherichia coli."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Escherichia phage RCS47",
"Eukaryota",
"Thermoproteati",
"metagenomes"
] | [
7497,
1,
3,
10,
107
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | DMSO reductase anchor subunit (DmsC) | DMSO reductase anchor subunit (DmsC) | DmsC | 8 |
IPR007060 | 7,060 | Septum formation initiator FtsL/DivIC | FtsL/DivIC | Family | 25,358 | false | false | FtsL and DivIC (FtsB) are essential components of this division machinery [ ]. In Bacillus subtilis DivIC is necessary for both vegetative and sporulation septum formation [ ]. These proteins are mainly composed of an N-terminal coiled-coil. DivIB, DivIC and FtsL inter-depend on each other for stabilisation and localis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04977"
] | [
"DivIC"
] | [
25358
] | 1 | [] | [] | [] | 0 | [
"5z2w",
"6h9n",
"6h9o",
"8bh1",
"8hhf",
"8hhg",
"8hhh",
"8p1u"
] | 8 | [
"PUB00008728",
"PUB00043360",
"PUB00070722"
] | [
"8113187",
"15659160",
"21672257"
] | [
"Characterization of a cell division gene from Bacillus subtilis that is required for vegetative and sporulation septum formation.",
"In vitro reconstitution of a trimeric complex of DivIB, DivIC and FtsL, and their transient co-localization at the division site in Streptococcus pneumoniae.",
"A model for the E... | [
1994,
2005,
2011
] | 3 | [] | [
"IPR023081",
"IPR039076"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24850,
12,
496
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Septum formation initiator FtsL/DivIC | Septum formation initiator FtsL/DivIC | FtsL/DivIC | 5 |
IPR007061 | 7,061 | Mycothiol-S-transferase | MST-like | Family | 19,133 | false | false | This entry, previously known as DUF664, represents the Mycothiol S-transferase (MST) from Mycobacterium tuberculosis and related proteins mainly found in Actinobacteria. MST binds to and is responsible for the transfer of Mycothiol (MSH) to xenobiotic acceptors. The ability of MST to catalyse this reaction depends on t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04978"
] | [
"MST"
] | [
19133
] | 1 | [] | [] | [] | 0 | [
"2ou6",
"8f5v",
"8fx9"
] | 3 | [
"PUB00158836"
] | [
"36970142"
] | [
"The <i>Mycobacterium tuberculosis</i> mycothiol <i>S</i>-transferase is divalent metal-dependent for mycothiol binding and transfer."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
19074,
3,
56
] | 3 | [] | [] | 0 | true | Family | Mycothiol-S-transferase | Mycothiol-S-transferase | MST-like | 9 |
IPR007062 | 7,062 | Protein phosphatase inhibitor 2 (IPP-2) | PPI-2 | Family | 5,730 | false | false | Protein phosphatase inhibitor 2 (IPP-2) is a phosphoprotein conserved among all eukaryotes, and it appears in both the nucleus and cytoplasm of tissue culture cells [ ]. Protein phosphatase inhibitor 2 family member C (PPP1R2C) has been shown to inhibit the catalytic subunit of PP1 [ ]. | [
"GO:0004864",
"GO:0009966"
] | [
"protein phosphatase inhibitor activity",
"regulation of signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04979",
"PTHR12398"
] | [
"IPP-2",
""
] | [
5722,
5340
] | 2 | [] | [] | [] | 0 | [
"2o8a",
"2o8g"
] | 2 | [
"PUB00008729",
"PUB00088389"
] | [
"12235284",
"11076525"
] | [
"Domains of type 1 protein phosphatase inhibitor-2 required for nuclear and cytoplasmic localization in response to cell-cell contact.",
"Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase."
] | [
2002,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5730
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
4,
9,
17,
1,
5,
12,
1,
1,
12
] | 12 | true | Family | Protein phosphatase inhibitor 2 (IPP-2) | Protein phosphatase inhibitor 2 (IPP-2) | PPI-2 | 8 |
IPR007064 | 7,064 | Nmd3, N-terminal | Nmd3_N | Domain | 6,257 | false | false | Nmd3 acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit [ , ]. This N-terminal region contains four conserved CXXC motifs that could be metal binding. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04981"
] | [
"NMD3"
] | [
6257
] | 1 | [] | [] | [] | 0 | [
"5h4p",
"5t62",
"5t6r",
"6lqm",
"6lsr",
"6lu8",
"6n8k",
"6n8l",
"6n8m",
"6n8n",
"6n8o",
"6qik",
"6qtz",
"6ri5",
"6rzz",
"6s05",
"7z34",
"8hfr"
] | 18 | [
"PUB00090080",
"PUB00090081"
] | [
"12773398",
"11086007"
] | [
"Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates.",
"Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit."
] | [
2003,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
891,
62,
5272,
32
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
2,
9,
3,
1,
7,
4,
1,
1,
7
] | 12 | true | Domain | Nmd3, N-terminal | Nmd3, N-terminal | Nmd3_N | 4 |
IPR007065 | 7,065 | HPP | HPP | Family | 9,845 | false | false | This entry represents a family of integral membrane proteins from all cellular organisms, including At3g47980 from Arabidopsis thaliana ( ), which is involved in nitrite transport [ ]. Members of this family have at least four transmembrane spanning helices. The most conserved region of an alignment of the proteins is ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33741"
] | [
""
] | [
9845
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155273"
] | [
"24904028"
] | [
"Nitrite transport activity of a novel HPP family protein conserved in cyanobacteria and chloroplasts."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
18,
7002,
2735,
90
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
1,
4,
10
] | 4 | true | Family | HPP | HPP | HPP | 6 |
IPR007066 | 7,066 | RNA polymerase Rpb1, domain 3 | RNA_pol_Rpb1_3 | Domain | 54,032 | false | false | RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delim... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04983"
] | [
"RNA_pol_Rpb1_3"
] | [
54032
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 209 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,206 | [
"PUB00002975",
"PUB00008731",
"PUB00076664"
] | [
"8910400",
"11313498",
"24153182"
] | [
"Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.",
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.",
"RNA polymerase I structure and transcript... | [
1996,
2001,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
966,
26797,
25151,
417,
701
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
28,
3,
5,
9,
1,
14,
14,
3,
12,
10,
3,
3,
67
] | 13 | true | Domain | RNA polymerase Rpb1, domain 3 | RNA polymerase Rpb1, domain 3 | RNA_pol_Rpb1_3 | 4 |
IPR007067 | 7,067 | Tail sheath protein | Tail_sheath | Family | 1,860 | false | false | This entry represents tail sheath proteins from various bacteriophages [ , ], including GpL from Bacteriophage Mu [ ] and Gp18 from Bacteriophage T4 [ , ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF007349"
] | [
"Tsp_L"
] | [
1860
] | 1 | [] | [] | [] | 0 | [
"9khy",
"9ki1",
"9lj8"
] | 3 | [
"PUB00020098",
"PUB00020099",
"PUB00020100",
"PUB00043658",
"PUB00052010"
] | [
"7676633",
"1825255",
"2963141",
"16125724",
"19229296"
] | [
"Tail sheath and tail tube genes of the temperate coliphage 186.",
"Nucleotide sequence of the genes encoding the major tail sheath and tail tube proteins of bacteriophage P2.",
"Nucleotide sequence of the tail tube structural gene of bacteriophage T4.",
"Structure of the central hub of bacteriophage Mu basep... | [
1995,
1991,
1988,
2005,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
1841,
13,
6
] | 3 | [] | [] | 0 | true | Family | Tail sheath protein | Tail sheath protein | Tail_sheath | 9 |
IPR007069 | 7,069 | Transposase, IS801/IS1294 | Transposase_32 | Domain | 7,372 | false | false | Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This entry represents a domain found at the C-terminal of transposases IS1294 and IS801, found associated with a zinc finger domain at the N-terminal ( ) [ ]. | [
"GO:0003677",
"GO:0004803",
"GO:0006313"
] | [
"DNA binding",
"transposase activity",
"DNA transposition"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04986"
] | [
"Y2_Tnp"
] | [
7372
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00034643"
] | [
"9870703"
] | [
"Insertion specificity and trans-activation of IS801."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Sym plasmid",
"unclassified sequences"
] | [
7152,
17,
27,
1,
175
] | 5 | [] | [] | 0 | true | Domain | Transposase, IS801/IS1294 | Transposase, IS801/IS1294 | Transposase_32 | 7 |
IPR007070 | 7,070 | GPI ethanolamine phosphate transferase 1 | GPI_EtnP_transferase_1 | Family | 5,859 | false | false | This entry represents GPI ethanolamine phosphate transferase 1 enzymes, including the yeast enzyme MCD4 and the mammalian homolgoue PIG-N (also known as phosphatidylinositolglycan class N) [ , ]. These enzymes are multi-pass endoplasmic reticulum membrane proteins involved in glycosylphosphatidylinositol (GPI)-anchor b... | [
"GO:0051377",
"GO:0006506",
"GO:0005789"
] | [
"mannose-ethanolamine phosphotransferase activity",
"GPI anchor biosynthetic process",
"endoplasmic reticulum membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR12250"
] | [
""
] | [
5859
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-162710",
"R-MMU-162710",
"R-SCE-162710",
"R-SPO-162710"
] | [
"REACTOME:R-HSA-162710",
"REACTOME:R-MMU-162710",
"REACTOME:R-SCE-162710",
"REACTOME:R-SPO-162710"
] | 4 | [] | 0 | [
"PUB00008732",
"PUB00008733"
] | [
"10574991",
"10069808"
] | [
"Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol.",
"MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast."
] | [
1999,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
5850
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
2,
3,
13,
28,
5,
1,
4,
9,
1,
1,
11
] | 12 | true | Family | GPI ethanolamine phosphate transferase 1 | GPI ethanolamine phosphate transferase 1 | GPI_EtnP_transferase_1 | 8 |
IPR007071 | 7,071 | A-kinase anchoring protein 95 (AKAP95) | AKAP95 | Family | 2,911 | false | false | A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA [ ]. | [
"GO:0003677",
"GO:0005634"
] | [
"DNA binding",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04988",
"PTHR12190"
] | [
"AKAP95",
""
] | [
2634,
2898
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9772755",
"R-MMU-9772755"
] | [
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-9772755"
] | 2 | [] | 0 | [
"PUB00008734"
] | [
"11964380"
] | [
"Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata",
"bird metagenome"
] | [
2909,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
23,
17,
15
] | 4 | true | Family | A-kinase anchoring protein 95 (AKAP95) | A-kinase anchoring protein 95 (AKAP95) | AKAP95 | 3 |
IPR007072 | 7,072 | Rhamnosyl O-methyltransferase | RNMT_CmcI | Family | 1,739 | false | false | This entry contains Rhamnosyl O-methyltransferase which catalyses the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD) [ ]. Members of this family are abou... | [
"GO:0008168",
"GO:0008610"
] | [
"methyltransferase activity",
"lipid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04989"
] | [
"RMNT_CmcI"
] | [
1739
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 146 | [
"2bm8",
"2bm9",
"2br3",
"2br4",
"2br5"
] | 5 | [
"PUB00008735",
"PUB00039678",
"PUB00053670"
] | [
"9696752",
"16527306",
"15292265"
] | [
"Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.",
"Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus.",
"Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolgly... | [
1998,
2006,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Solivirus sp.",
"metagenomes"
] | [
15,
1417,
226,
1,
80
] | 5 | [] | [] | 0 | true | Family | Rhamnosyl O-methyltransferase | Rhamnosyl O-methyltransferase | RNMT_CmcI | 6 |
IPR007073 | 7,073 | RNA polymerase Rpb1, domain 7 | RNA_pol_Rpb1_7 | Domain | 7,312 | false | false | RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 interacts with the lobe domain of Rpb... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04990"
] | [
"RNA_pol_Rpb1_7"
] | [
7312
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 172 | [
"1i3q",
"1i50",
"1i6h",
"1k83",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"2b63",
"2b8k",
"2e2h",
"2e2i",
"2e2j",
"2ja5",
"2ja6",
"2ja7",
"2ja8",
"2nvq",
"2nvt"... | 411 | [
"PUB00002975",
"PUB00008731"
] | [
"8910400",
"11313498"
] | [
"Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.",
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution."
] | [
1996,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Eubacterium ramulus",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1,
7021,
69,
221
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
9,
4,
3,
1,
4,
3,
1,
1,
8
] | 12 | true | Domain | RNA polymerase Rpb1, domain 7 | RNA polymerase Rpb1, domain 7 | RNA_pol_Rpb1_7 | 2 |
IPR007074 | 7,074 | LicD/FKTN/FKRP, nucleotidyltransferase domain | LicD/FKTN/FKRP_NTP_transf | Domain | 11,247 | false | false | The LicD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [ ]. These proteins are part of the nucleotidyltransfer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04991"
] | [
"LicD"
] | [
11247
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9939291",
"R-MMU-9939291"
] | [
"REACTOME:R-HSA-9939291",
"REACTOME:R-MMU-9939291"
] | 2 | [
"6kaj",
"6kak",
"6kal",
"6kam",
"6kan",
"6l7s",
"6l7t",
"6l7u"
] | 8 | [
"PUB00008737",
"PUB00044679",
"PUB00066751",
"PUB00084174",
"PUB00098859",
"PUB00100300",
"PUB00100301"
] | [
"10200966",
"11445638",
"19833706",
"27194101",
"29477842",
"31949166",
"22922256"
] | [
"Pneumococcal licD2 gene is involved in phosphorylcholine metabolism.",
"Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy.",
"Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.",
"I... | [
1999,
2001,
2009,
2016,
2018,
2020,
2012
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
60,
4647,
6378,
30,
132
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
4,
8,
5,
2,
5,
2
] | 7 | true | Domain | LicD/FKTN/FKRP, nucleotidyltransferase domain | LicD/FKTN/FKRP, nucleotidyltransferase domain | LicD/FKTN/FKRP_NTP_transf | 1 |
IPR007075 | 7,075 | RNA polymerase Rpb1, domain 6 | RNA_pol_Rpb1_6 | Domain | 8,794 | false | false | RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [ , ].... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04992"
] | [
"RNA_pol_Rpb1_6"
] | [
8794
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 172 | [
"1i3q",
"1i50",
"1i6h",
"1k83",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"2b63",
"2b8k",
"2e2h",
"2e2i",
"2e2j",
"2ja5",
"2ja6",
"2ja7",
"2ja8",
"2nvq",
"2nvt"... | 396 | [
"PUB00002975",
"PUB00008731"
] | [
"8910400",
"11313498"
] | [
"Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.",
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution."
] | [
1996,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Hujiaoplasma nucleasis",
"Viruses",
"metagenomes"
] | [
8532,
1,
51,
210
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
9,
3,
3,
1,
4,
2,
1,
1,
8
] | 12 | true | Domain | RNA polymerase Rpb1, domain 6 | RNA polymerase Rpb1, domain 6 | RNA_pol_Rpb1_6 | 3 |
IPR007076 | 7,076 | TfoX, N-terminal | TfoX_N | Domain | 8,821 | false | false | This entry represents the N-terminal domain of TfoX from Haemophilus influenzae. TfoX Positively regulates genes required for DNA transformation (late competence-specific genes) in association with CRP [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04993"
] | [
"TfoX_N"
] | [
8821
] | 1 | [] | [] | [] | 0 | [
"2od0"
] | 1 | [
"PUB00078799",
"PUB00078800",
"PUB00078801"
] | [
"17068078",
"22532864",
"18761017"
] | [
"Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria.",
"Natural DNA uptake by Escherichia coli.",
"CRP binding and transcription activation at CRP-S sites."
] | [
2006,
2012,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
27,
8746,
5,
43
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | TfoX, N-terminal | TfoX, N-terminal | TfoX_N | 9 |
IPR007077 | 7,077 | TfoX, C-terminal | TfoX_C | Domain | 4,730 | false | false | This domain is found in a number of bacterial proteins including the TfoX gene product of Haemophilus influenzae. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [ ]. This family corresponds to the C-terminal presumed domain of TfoX. The d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04994"
] | [
"TfoX_C"
] | [
4730
] | 1 | [] | [] | [] | 0 | [
"3bqt",
"3mab"
] | 2 | [
"PUB00008739"
] | [
"7724607"
] | [
"Identification of a DNA transformation gene required for com101A+ expression and supertransformer phenotype in Haemophilus influenzae."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
31,
4662,
6,
31
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | TfoX, C-terminal | TfoX, C-terminal | TfoX_C | 9 |
IPR007078 | 7,078 | Haem exporter protein D (CcmD) | Haem_export_protD_CcmD | Family | 6,874 | false | false | The CcmD protein is part of a C-type cytochrome biogenesis operon [ ]. CcmD interacts with CcmE and CcmC, establishing a cytoplasm to periplasm haem delivery pathway [ , ]. CcmD is a component of the CcmABC ATP-binding cassette transporter complex. It is not necessary for the CcmC-dependent transfer of heme to CcmE in ... | [
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"NCBIFAM"
] | [
"PF04995",
"TIGR03141"
] | [
"CcmD",
"cytochro_ccmD"
] | [
6824,
6509
] | 2 | [
"GP"
] | [
"GenProp0678"
] | [
"GP:GenProp0678"
] | 1 | [
"7f02",
"7f03",
"7f04",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 9 | [
"PUB00002274",
"PUB00008740",
"PUB00060977",
"PUB00060978"
] | [
"7635817",
"10998170",
"15513913",
"18326572"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"New insights into the role of CcmC, CcmD and CcmE in the haem delivery pathway during cytochrome c maturation by a complete mutational analysis of the conserved tryptophan-rich motif of CcmC.",
"CcmD is involved in complex formation between CcmC a... | [
1995,
2000,
2005,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cyprideis torosa",
"unclassified sequences"
] | [
6789,
1,
84
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Haem exporter protein D (CcmD) | Haem exporter protein D (CcmD) | Haem_export_protD_CcmD | 5 |
IPR007079 | 7,079 | Succinylarginine dihydrolase | SuccinylArg_d-Hdrlase_AstB | Family | 5,052 | false | false | Succinylarginine dihydrolase (AstB) transforms N(2)-succinylglutamate into succinate and glutamate. This enzyme is the second in the five-step ammonia-producing arginine succinyltransferase pathway, the major pathway in Escherichia coli and in other related bacteria for arginine catabolism as a sole nitrogen source. As... | [
"GO:0009015",
"GO:0006525"
] | [
"N-succinylarginine dihydrolase activity",
"arginine metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"NCBIFAM"
] | [
"MF_01172",
"NF009789",
"PF04996",
"TIGR03241"
] | [
"AstB",
"PRK13281.1",
"AstB",
"arg_catab_astB"
] | [
4709,
4804,
5052,
4253
] | 4 | [
"EC",
"GP",
"GP"
] | [
"3.5.3.23",
"GenProp0309",
"GenProp1280"
] | [
"EC:3.5.3.23",
"GP:GenProp0309",
"GP:GenProp1280"
] | 3 | [
"1ynf",
"1ynh",
"1yni"
] | 3 | [
"PUB00034681"
] | [
"15703173"
] | [
"Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5031,
2,
19
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Succinylarginine dihydrolase | Succinylarginine dihydrolase | SuccinylArg_d-Hdrlase_AstB | 1 |
IPR007080 | 7,080 | RNA polymerase Rpb1, domain 1 | RNA_pol_Rpb1_1 | Domain | 75,216 | false | false | RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 1, represents the clamp domain, which is a mobile domain involved in positioning the DNA, maintenan... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04997"
] | [
"RNA_pol_Rpb1_1"
] | [
75216
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 209 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,210 | [
"PUB00002975",
"PUB00008731",
"PUB00076664"
] | [
"8910400",
"11313498",
"24153182"
] | [
"Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.",
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.",
"RNA polymerase I structure and transcript... | [
1996,
2001,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
979,
28385,
44615,
384,
853
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
3,
5,
7,
1,
13,
17,
3,
23,
7,
3,
3,
50
] | 13 | true | Domain | RNA polymerase Rpb1, domain 1 | RNA polymerase Rpb1, domain 1 | RNA_pol_Rpb1_1 | 1 |
IPR007083 | 7,083 | RNA polymerase Rpb1, domain 4 | RNA_pol_Rpb1_4 | Domain | 64,177 | false | false | RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This entry, domain 4, represents the funnel domain. The funnel domain contains the binding site for some elongation fac... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF05000"
] | [
"RNA_pol_Rpb1_4"
] | [
64177
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 209 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,213 | [
"PUB00002975",
"PUB00008731"
] | [
"8910400",
"11313498"
] | [
"Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.",
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution."
] | [
1996,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
964,
25171,
36955,
417,
670
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
28,
3,
5,
9,
1,
14,
13,
3,
17,
8,
3,
3,
52
] | 13 | true | Domain | RNA polymerase Rpb1, domain 4 | RNA polymerase Rpb1, domain 4 | RNA_pol_Rpb1_4 | 2 |
IPR007084 | 7,084 | BRICHOS domain | BRICHOS_dom | Domain | 9,063 | false | false | The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer, including BRI-2, chondromodulin-I (ChM-I), CA11, and surfactant protein C [ ]. Its exact function is unknown; roles that have been proposed for it include (a) targeting the protein to the secretory pathway, (b)... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF04089",
"PS50869",
"SM01039"
] | [
"BRICHOS",
"BRICHOS",
"BRICHOS"
] | [
8834,
8877,
8607
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50869",
"R-HSA-5683826",
"R-HSA-5688354",
"R-HSA-5688849",
"R-HSA-5688890",
"R-HSA-977225",
"R-MMU-5683826",
"R-RNO-5683826"
] | [
"PROSITEDOC:PDOC50869",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-5688354",
"REACTOME:R-HSA-5688849",
"REACTOME:R-HSA-5688890",
"REACTOME:R-HSA-977225",
"REACTOME:R-MMU-5683826",
"REACTOME:R-RNO-5683826"
] | 8 | [
"2yad",
"8ovi",
"8ox2",
"8rnu"
] | 4 | [
"PUB00014776"
] | [
"12114016"
] | [
"BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Acinetobacter populi",
"Eumetazoa",
"bird metagenome"
] | [
1,
9060,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
14,
3,
31,
22,
29
] | 6 | true | Domain | BRICHOS domain | BRICHOS domain | BRICHOS_dom | 2 |
IPR007085 | 7,085 | DNA/pantothenate metabolism flavoprotein, C-terminal | DNA/pantothenate-metab_flavo_C | Domain | 29,904 | false | false | This entry represents the C-terminal domain found in DNA/pantothenate metabolism flavoproteins, which affects synthesis of DNA and pantothenate metabolism. These proteins contain ATP, phosphopantothenate, and cysteine binding sites. The structure of this domain has been determined in human phosphopantothenoylcysteine (... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04127"
] | [
"DFP"
] | [
29904
] | 1 | [
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.1.36",
"6.3.2.5",
"GenProp1561",
"PWY-7851",
"PWY-8342",
"R-HSA-196783",
"R-MMU-196783",
"R-SCE-196783",
"R-SPO-196783"
] | [
"EC:4.1.1.36",
"EC:6.3.2.5",
"GP:GenProp1561",
"METACYC:PWY-7851",
"METACYC:PWY-8342",
"REACTOME:R-HSA-196783",
"REACTOME:R-MMU-196783",
"REACTOME:R-SCE-196783",
"REACTOME:R-SPO-196783"
] | 9 | [
"1p9o",
"1u7u",
"1u7w",
"1u7z",
"1u80",
"2gk4",
"4qji",
"5int",
"6ai8",
"6ai9",
"6aik",
"6aim",
"6aip",
"6tgv",
"6th2",
"6thc",
"7edz",
"8ow5",
"8owb",
"8owp",
"8owq",
"8owr"
] | 22 | [
"PUB00029787",
"PUB00031697"
] | [
"12906824",
"15530362"
] | [
"Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.",
"Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase."
] | [
2003,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
886,
24746,
3598,
28,
646
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
15,
1,
1,
2,
1,
2,
1,
3,
4,
1,
1,
12
] | 12 | true | Domain | DNA/pantothenate metabolism flavoprotein, C-terminal | DNA/pantothenate metabolism flavoprotein, C-terminal | DNA/pantothenate-metab_flavo_C | 3 |
IPR007094 | 7,094 | RNA-directed RNA polymerase, catalytic domain | RNA-dir_pol_PSvirus | Domain | 108,895 | false | false | This entry represents the catalytic domain of the RNA-directed RNA polymerase from all positive-strand RNA eukaryotic viruses with no DNA stage. RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA ... | [
"GO:0003968",
"GO:0039694"
] | [
"RNA-directed RNA polymerase activity",
"viral RNA genome replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS50507"
] | [
"RDRP_SSRNA_POS"
] | [
108895
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7",
"2.7.7.48",
"3.4.22",
"3.6.4",
"PDOC50507",
"R-HSA-191859",
"R-HSA-5621480",
"R-HSA-8854214",
"R-HSA-918233",
"R-HSA-9679504",
"R-HSA-9682706",
"R-HSA-9682708",
"R-HSA-9683439",
"R-HSA-9684325",
"R-HSA-9692916",
"R-HSA-9694271",
"R-HSA-9694301",
"R-HSA-9694676",
"R-HSA-9... | [
"EC:2.7.7",
"EC:2.7.7.48",
"EC:3.4.22",
"EC:3.6.4",
"PROSITEDOC:PDOC50507",
"REACTOME:R-HSA-191859",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-9679504",
"REACTOME:R-HSA-9682706",
"REACTOME:R-HSA-9682708",
"REACTOME:R-HSA-9683439",
"REACTOM... | 23 | [
"1c2p",
"1csj",
"1gx5",
"1gx6",
"1khv",
"1khw",
"1nb4",
"1nb6",
"1nb7",
"1nhu",
"1nhv",
"1os5",
"1quv",
"1ra6",
"1ra7",
"1raj",
"1rdr",
"1s48",
"1s49",
"1s4f",
"1sh0",
"1sh2",
"1sh3",
"1tp7",
"1tql",
"1u09",
"1wne",
"1xr5",
"1xr6",
"1xr7",
"1yuy",
"1yv2"... | 613 | [
"PUB00009392",
"PUB00030617",
"PUB00033622",
"PUB00033623",
"PUB00033624",
"PUB00033625"
] | [
"9878607",
"9309225",
"2759231",
"8709232",
"11531403",
"10827187"
] | [
"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.",
"Structure of the RNA-dependent RNA polymerase of poliovirus.",
"Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat... | [
1998,
1997,
1989,
1996,
2001,
2000
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobrevibacter thaueri",
"Viruses",
"metagenomes"
] | [
56,
203,
1,
108558,
77
] | 5 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, catalytic domain | RNA-directed RNA polymerase, catalytic domain | RNA-dir_pol_PSvirus | 6 |
IPR007096 | 7,096 | RNA-directed RNA polymerase, catalytic domain, bacteriophage | RNA-dir_Rpol_cat_phage | Domain | 2,409 | false | false | RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw... | [
"GO:0003968",
"GO:0019079"
] | [
"RNA-directed RNA polymerase activity",
"viral genome replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS50522"
] | [
"RDRP_PHAGE"
] | [
2409
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.7.48",
"PDOC50507"
] | [
"EC:2.7.7.48",
"PROSITEDOC:PDOC50507"
] | 2 | [
"1hhs",
"1hht",
"1hi0",
"1hi1",
"1hi8",
"1uvi",
"1uvj",
"1uvk",
"1uvl",
"1uvm",
"1uvn",
"1wac",
"2jl9",
"2jlf",
"2jlg",
"3agp",
"3agq",
"3avt",
"3avu",
"3avv",
"3avw",
"3avx",
"3avy",
"3mmp",
"3vnu",
"3vnv",
"4a8f",
"4a8k",
"4a8m",
"4a8o",
"4a8q",
"4a8s"... | 43 | [
"PUB00009392",
"PUB00030617",
"PUB00033622",
"PUB00033623",
"PUB00033624",
"PUB00033625"
] | [
"9878607",
"9309225",
"2759231",
"8709232",
"11531403",
"10827187"
] | [
"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.",
"Structure of the RNA-dependent RNA polymerase of poliovirus.",
"Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat... | [
1998,
1997,
1989,
1996,
2001,
2000
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halopenitus malekzadehii",
"Viruses",
"hydrothermal vent metagenome"
] | [
33,
57,
1,
2317,
1
] | 5 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, catalytic domain, bacteriophage | RNA-directed RNA polymerase, catalytic domain, bacteriophage | RNA-dir_Rpol_cat_phage | 4 |
IPR007097 | 7,097 | RNA-directed RNA polymerase, reovirus | RNA-dir_pol_reovirus | Domain | 4,921 | false | false | RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw... | [
"GO:0003723",
"GO:0003968",
"GO:0019079"
] | [
"RNA binding",
"RNA-directed RNA polymerase activity",
"viral genome replication"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROFILE"
] | [
"PS50523"
] | [
"RDRP_DSRNA_REO"
] | [
4921
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.7.48",
"PDOC50507"
] | [
"EC:2.7.7.48",
"PROSITEDOC:PDOC50507"
] | 2 | [
"1muk",
"1mwh",
"1n1h",
"1n35",
"1n38",
"1uon",
"2cse",
"2r7o",
"2r7q",
"2r7r",
"2r7s",
"2r7t",
"2r7u",
"2r7v",
"2r7w",
"2r7x",
"3ja4",
"3ja5",
"3jb6",
"3jb7",
"4au6",
"4f5x",
"5h0r",
"5zvs",
"6k32",
"6m99",
"6ogy",
"6ogz",
"6oj3",
"6oj4",
"6oj5",
"6oj6"... | 53 | [
"PUB00009392",
"PUB00030617",
"PUB00033622",
"PUB00033623",
"PUB00033624",
"PUB00033625"
] | [
"9878607",
"9309225",
"2759231",
"8709232",
"11531403",
"10827187"
] | [
"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.",
"Structure of the RNA-dependent RNA polymerase of poliovirus.",
"Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat... | [
1998,
1997,
1989,
1996,
2001,
2000
] | 6 | [] | [] | 0 | 0 | null | [
"Viruses",
"viral metagenome"
] | [
4920,
1
] | 2 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, reovirus | RNA-directed RNA polymerase, reovirus | RNA-dir_pol_reovirus | 2 |
IPR007099 | 7,099 | RNA-directed RNA polymerase, negative-strand RNA virus | RNA-dir_pol_NSvirus | Domain | 71,656 | false | false | RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw... | [
"GO:0003968",
"GO:0039694"
] | [
"RNA-directed RNA polymerase activity",
"viral RNA genome replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS50525"
] | [
"RDRP_SSRNA_NEG_SEG"
] | [
71656
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"PDOC50507",
"R-HSA-168255",
"R-HSA-168271",
"R-HSA-168275",
"R-HSA-168288",
"R-HSA-168298",
"R-HSA-168302",
"R-HSA-168303",
"R-HSA-168325",
"R-HSA-168330",
"R-HSA-168333",
"R-HSA-168336",
"R-HSA-192814",
"R-HSA-192823",
"R-HSA-192869",
"R-HSA-192905"
] | [
"EC:2.7.7.48",
"PROSITEDOC:PDOC50507",
"REACTOME:R-HSA-168255",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168275",
"REACTOME:R-HSA-168288",
"REACTOME:R-HSA-168298",
"REACTOME:R-HSA-168302",
"REACTOME:R-HSA-168303",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168330",
"REACTOME:R-HSA-168333",
"RE... | 17 | [
"4wrt",
"4wsa",
"4wsb",
"5amq",
"5amr",
"5d98",
"5d9a",
"5epi",
"5fmz",
"5m3h",
"5m3j",
"5msg",
"6evj",
"6evk",
"6f5o",
"6f5p",
"6fhh",
"6fhi",
"6klc",
"6kld",
"6kle",
"6klh",
"6kuj",
"6kuk",
"6kup",
"6kur",
"6kut",
"6kuu",
"6kuv",
"6kv5",
"6l42",
"6qcs"... | 209 | [
"PUB00009392",
"PUB00030617",
"PUB00033622",
"PUB00033623",
"PUB00033624",
"PUB00033625"
] | [
"9878607",
"9309225",
"2759231",
"8709232",
"11531403",
"10827187"
] | [
"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.",
"Structure of the RNA-dependent RNA polymerase of poliovirus.",
"Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat... | [
1998,
1997,
1989,
1996,
2001,
2000
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
8,
67,
71581
] | 3 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, negative-strand RNA virus | RNA-directed RNA polymerase, negative-strand RNA virus | RNA-dir_pol_NSvirus | 2 |
IPR007100 | 7,100 | Birnavirus RNA-directed RNA polymerase, palm domain | Birnavirus_RdRp_palm | Domain | 1,140 | false | false | RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw... | [
"GO:0003968",
"GO:0019079"
] | [
"RNA-directed RNA polymerase activity",
"viral genome replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04197"
] | [
"Birna_RdRp_palm"
] | [
1140
] | 1 | [
"EC"
] | [
"2.7.7.48"
] | [
"EC:2.7.7.48"
] | 1 | [
"2pgg",
"2pus",
"2qj1",
"2r70",
"2r72",
"2yi8",
"2yi9",
"2yia",
"2yib",
"3zed"
] | 10 | [
"PUB00009392",
"PUB00009899",
"PUB00030617",
"PUB00033622",
"PUB00033623",
"PUB00033624",
"PUB00033625",
"PUB00042370"
] | [
"9878607",
"12069523",
"9309225",
"2759231",
"8709232",
"11531403",
"10827187",
"17456597"
] | [
"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.",
"Birnavirus VP1 proteins form a distinct subgroup of RNA-dependent RNA polymerases lacking a GDD motif.",
"Structure of the RNA-dependent RNA polymerase of... | [
1998,
2002,
1997,
1989,
1996,
2001,
2000,
2007
] | 8 | [] | [] | 0 | 0 | null | [
"Parasteatoda tepidariorum",
"Viruses"
] | [
1,
1139
] | 2 | [] | [] | 0 | true | Domain | Birnavirus RNA-directed RNA polymerase, palm domain | Birnavirus RNA-directed RNA polymerase, palm domain | Birnavirus_RdRp_palm | 1 |
IPR007109 | 7,109 | Brix domain | Brix | Domain | 23,920 | false | false | Analysis of the Brix (biogenesis of ribosomes in Xenopus) protein leaded to the identification of a region of 150-180 residues length, called the Brix domain, which is found in six protein families: one archaean family (I) including hypothetical proteins (one per genome); and five eukaryote families, each named accordi... | [
"GO:0019843",
"GO:0006364"
] | [
"rRNA binding",
"rRNA processing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF04427",
"PS50833",
"SM00879"
] | [
"Brix",
"BRIX",
"Brix"
] | [
23004,
23761,
22462
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50833",
"R-BTA-6791226",
"R-CEL-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"PROSITEDOC:PDOC50833",
"REACTOME:R-BTA-6791226",
"REACTOME:R-CEL-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 9 | [
"1w94",
"2cxh",
"3jct",
"4xd9",
"5a53",
"5by8",
"5jpq",
"5o9e",
"5oql",
"5wlc",
"5wxl",
"5wyj",
"5wyk",
"5z1g",
"5z3g",
"6c0f",
"6cb1",
"6elz",
"6em1",
"6em3",
"6em4",
"6em5",
"6ft6",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6m62"... | 136 | [
"PUB00018304",
"PUB00018305",
"PUB00060567",
"PUB00095726"
] | [
"11406393",
"11246005",
"12702244",
"15489263"
] | [
"The Brix domain protein family -- a key to the ribosomal biogenesis pathway?",
"The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component.",
"Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes.",
"Imp3p and Imp4p mediate formation of essentia... | [
2001,
2001,
2003,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
331,
8,
23578,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
5,
11,
8,
21,
14,
5,
24,
21,
6,
5,
39
] | 12 | true | Domain | Brix domain | Brix domain | Brix | 2 |
IPR007110 | 7,110 | Immunoglobulin-like domain | Ig-like_dom | Domain | 776,676 | false | false | The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, ... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS50835"
] | [
"IG_LIKE"
] | [
776676
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50835",
"R-BTA-114608",
"R-BTA-1236974",
"R-BTA-1236977",
"R-BTA-163125",
"R-BTA-1971475",
"R-BTA-198933",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-202733",
"R-BTA-2029481",
"R-BTA-2029482",
"R-BTA-2029485",
"R-BTA-210993",
"R-BTA-216083",
"R-BTA-2173791",
"R-... | [
"PROSITEDOC:PDOC50835",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1236974",
"REACTOME:R-BTA-1236977",
"REACTOME:R-BTA-163125",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-2022870",
"REACTOME:R-BTA-2022923",
"REACTOME:R-BTA-2024101",
"REACTOME:R-BTA-202733",
"REACTOME:R-BT... | 1,082 | [
"12e8",
"15c8",
"1a0q",
"1a14",
"1a1m",
"1a1n",
"1a1o",
"1a2y",
"1a3l",
"1a3r",
"1a4j",
"1a4k",
"1a5f",
"1a6a",
"1a6t",
"1a6u",
"1a6v",
"1a6w",
"1a6z",
"1a7n",
"1a7o",
"1a7p",
"1a7q",
"1a7r",
"1a8j",
"1a9b",
"1a9e",
"1ac6",
"1acy",
"1ad0",
"1ad9",
"1adq"... | 14,039 | [
"PUB00010610",
"PUB00014840",
"PUB00015110",
"PUB00027656"
] | [
"11377196",
"9417933",
"15327963",
"10698639"
] | [
"Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state.",
"Sequence profiles of immunoglobulin and immunoglobulin-like domains.",
"Protein--protein recognition: juxtaposition of domain and interface cores in immunoglobulins and ot... | [
2001,
1997,
2004,
2000
] | 4 | [] | [
"IPR003597",
"IPR003598",
"IPR003599",
"IPR013098",
"IPR013162",
"IPR053896",
"IPR055139",
"IPR060200"
] | 0 | 8 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
129,
8666,
764244,
3401,
236
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
170,
3587,
592,
36898,
3506,
9,
2870,
24
] | 9 | true | Domain | Immunoglobulin-like domain | Immunoglobulin-like domain | Ig-like_dom | 2 |
IPR007111 | 7,111 | NACHT nucleoside triphosphatase | NACHT_NTPase | Domain | 76,149 | false | false | The NACHT domain is a 300 to 400 residue predicted nucleoside triphosphatase (NTPase) domain, which is found in animal, fungal and bacterial proteins. The NACHT domain has been named after NAIP, CIITA, HET-E and TP1. It is found in association with other domains, such as the CARD domain ( ), the DAPIN domain ( ), the H... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF05729",
"PS50837"
] | [
"NACHT",
"NACHT"
] | [
58535,
66475
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50837",
"R-BTA-168638",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5689896",
"R-BTA-5689901",
"R-BTA-844456",
"R-DRE-844456",
"R-HSA-1606341",
"R-HSA-168638",
"R-HSA-168928",
"R-HSA-3134975",
"R-HSA-3270619",
"R-HSA-445989",
"R-HSA-450302",
"R-HSA-450321",
"R-HSA-5689896",
"R-HSA-... | [
"PROSITEDOC:PDOC50837",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-5689901",
"REACTOME:R-BTA-844456",
"REACTOME:R-DRE-844456",
"REACTOME:R-HSA-1606341",
"REACTOME:R-HSA-168638",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-3... | 46 | [
"3jbl",
"4kxf",
"5aj2",
"5irl",
"5irm",
"5irn",
"5yud",
"6b5b",
"6npy",
"6x6a",
"6x6c",
"7alv",
"7crw",
"7lfh",
"7pzc",
"7rav",
"7vtp",
"7vtq",
"7wbt",
"7wbu",
"7wge",
"7zgu",
"8dgc",
"8ej4",
"8etr",
"8fml",
"8fvu",
"8fw2",
"8fw9",
"8h93",
"8h94",
"8h95"... | 52 | [
"PUB00007270"
] | [
"10782090"
] | [
"The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
121,
9687,
66308,
2,
31
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
1011,
1,
104,
117,
5,
112
] | 7 | true | Domain | NACHT nucleoside triphosphatase | NACHT nucleoside triphosphatase | NACHT_NTPase | 4 |
IPR007112 | 7,112 | Expansin/pollen allergen, DPBB domain | Expansin/allergen_DPBB_dom | Domain | 27,054 | false | false | This entry represents a N-terminal domain that has a Barwin-like double psi β-barrel structure(DPBB). It is found in proteins like expasin and pollen allergens. The major timothy grass pollen allergen Phl p 1 is one of the most potent and frequently recognised environmental allergens [ ]. | [] | [] | [] | 0 | [
"PROFILE",
"SMART"
] | [
"PS50842",
"SM00837"
] | [
"EXPANSIN_EG45",
"DPBB_1"
] | [
26988,
19886
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50842"
] | [
"PROSITEDOC:PDOC50842"
] | 1 | [
"1n10",
"2hcz",
"3x2g",
"3x2h",
"3x2i",
"3x2l",
"3x2m",
"3x2n",
"3x2o",
"3x2p",
"4zm7",
"5kjo",
"5kjq",
"7wvr",
"7xc8",
"8bzq"
] | 16 | [
"PUB00034492"
] | [
"16750995"
] | [
"Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: importance for allergenic activity."
] | [
2006
] | 1 | [
"IPR009009"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Pandoravirus",
"uncultured microorganism"
] | [
405,
26646,
2,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
163,
127,
285
] | 3 | true | Domain | Expansin/pollen allergen, DPBB domain | Expansin/pollen allergen, DPBB domain | Expansin/allergen_DPBB_dom | 3 |
IPR007115 | 7,115 | 6-pyruvoyl tetrahydropterin synthase/QueD family | 6-PTP_synth/QueD | Family | 24,426 | false | false | 6-Pyruvoyl tetrahydrobiopterin synthase (PTPS) catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP [ ]. The functional enzyme is a hexamer of identical subunits. A transition metal binding site for... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF01242",
"PIRSF006113",
"PTHR12589",
"TIGR00039"
] | [
"PTPS",
"PTP_synth",
"",
"6PTHBS"
] | [
24404,
11739,
22314,
1383
] | 4 | [
"EC",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.2.50",
"GenProp1602",
"GenProp1632",
"PWY-6703",
"R-CEL-1474151",
"R-DDI-1474151",
"R-DME-1474151",
"R-HSA-1474151",
"R-MMU-1474151",
"R-RNO-1474151"
] | [
"EC:4.1.2.50",
"GP:GenProp1602",
"GP:GenProp1632",
"METACYC:PWY-6703",
"REACTOME:R-CEL-1474151",
"REACTOME:R-DDI-1474151",
"REACTOME:R-DME-1474151",
"REACTOME:R-HSA-1474151",
"REACTOME:R-MMU-1474151",
"REACTOME:R-RNO-1474151"
] | 10 | [
"1b66",
"1b6z",
"1gtq",
"1y13",
"2a0s",
"2dj6",
"2dtt",
"2g64",
"2oba",
"3d7j",
"3i2b",
"3jyg",
"3lx3",
"3lze",
"3m0n",
"3qn0",
"3qn9",
"3qna",
"4ntk",
"4ntm",
"4ntn",
"7v0f"
] | 22 | [
"PUB00001245",
"PUB00015311",
"PUB00015312",
"PUB00035932",
"PUB00106884"
] | [
"8137809",
"7563095",
"9165069",
"14660578",
"19231875"
] | [
"Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis.",
"6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the ... | [
1994,
1995,
1997,
2004,
2009
] | 5 | [] | [
"IPR017543"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1057,
20338,
2406,
164,
461
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
1,
7,
2,
7
] | 7 | true | Family | 6-pyruvoyl tetrahydropterin synthase/QueD family | 6-pyruvoyl tetrahydropterin synthase/QueD family | 6-PTP_synth/QueD | 7 |
IPR007117 | 7,117 | Expansin, cellulose-binding-like domain | Expansin_CBD | Domain | 21,199 | false | false | Expansins are secreted proteins of 25 to 27 Kd that were isolated first from young cucumber seedling and subsequently from other plant tissues. Expression of expansin genes correlates with growth of cells. Increase in expansin content also occurs during fruit ripening. Expansins act on the cell wall to promote its exte... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF01357",
"PS50843"
] | [
"Expansin_C",
"EXPANSIN_CBD"
] | [
20951,
20642
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50842"
] | [
"PROSITEDOC:PDOC50842"
] | 1 | [
"1bmw",
"1n10",
"1who",
"1whp",
"2hcz",
"2jnz",
"2vxq",
"3ft1",
"3ft9",
"4jcw",
"4jjo",
"4js7",
"4l48",
"7xc8"
] | 14 | [
"PUB00007272",
"PUB00007273",
"PUB00007274",
"PUB00018318",
"PUB00041365"
] | [
"11641069",
"9177257",
"11553760",
"11014181",
"16984999"
] | [
"Expansins: ever-expanding numbers and functions.",
"Group I allergens of grass pollen as cell wall-loosening agents.",
"A fungal endoglucanase with plant cell wall extension activity.",
"Loosening of plant cell walls by expansins.",
"Crystal structure and activities of EXPB1 (Zea m 1), a beta-expansin and ... | [
2001,
1997,
2001,
2000,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"ecological metagenomes"
] | [
236,
20957,
4,
2
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
154,
150,
322
] | 3 | true | Domain | Expansin, cellulose-binding-like domain | Expansin, cellulose-binding-like domain | Expansin_CBD | 2 |
IPR007118 | 7,118 | Expansin/Lol pI | Expan_Lol_pI | Family | 20,100 | false | false | Expansins are unusual proteins that mediate cell wall extension in plants [ ]. They are believed to act as a sort of chemical grease, allowing polymers to slide past one another by disrupting non-covalent hydrogen bonds that hold many wall polymers to one another. This process is not degradative and hence does not weak... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01225"
] | [
"EXPANSNFAMLY"
] | [
20100
] | 1 | [] | [] | [] | 0 | [
"1n10",
"2hcz",
"7xc8"
] | 3 | [
"PUB00006126",
"PUB00007280"
] | [
"7568110",
"7930302"
] | [
"Molecular cloning and sequence analysis of expansins--a highly conserved, multigene family of proteins that mediate cell wall extension in plants.",
"Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from ei... | [
1995,
1994
] | 2 | [] | [
"IPR002963",
"IPR005795"
] | 0 | 2 | 0 | [
"Eukaryota",
"Streptomyces acidiscabies"
] | [
20098,
2
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
156,
113,
287
] | 3 | true | Family | Expansin/Lol pI | Expansin/Lol pI | Expan_Lol_pI | 9 |
IPR007119 | 7,119 | Phage tail spike protein, N-terminal domain | Phage_tail_spike_N | Domain | 3,873 | false | false | This entry represents the conserved N-terminal domain found in Tail spike protein from Bacillus phage SPP1 (Gp21) and similar sequences from tailed bacteriophages and bacterial prophages. Gp21 binds to the host entry receptor YueB and triggers viral DNA ejection. This interaction initiates a cascade of conformational c... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01665"
] | [
"put_anti_recept"
] | [
3873
] | 1 | [
"GP"
] | [
"GenProp0208"
] | [
"GP:GenProp0208"
] | 1 | [] | 0 | [
"PUB00151022"
] | [
"22171743"
] | [
"Role of bacteriophage SPP1 tail spike protein gp21 on host cell receptor binding and trigger of phage DNA ejection."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"Viruses",
"metagenomes"
] | [
3319,
4,
534,
16
] | 4 | [] | [] | 0 | true | Domain | Phage tail spike protein, N-terminal domain | Phage tail spike protein, N-terminal domain | Phage_tail_spike_N | 1 |
IPR007120 | 7,120 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | DNA-dir_RNAP_su2_dom | Domain | 82,751 | false | false | RNA polymerases ( ) catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain represents the hybrid-binding domain and the wall domain [ ]. The hybrid-binding domain binds the nasce... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF00562"
] | [
"RNA_pol_Rpb2_6"
] | [
82751
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 214 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,225 | [
"PUB00008731"
] | [
"11313498"
] | [
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1254,
33885,
45952,
539,
1121
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
29,
3,
4,
4,
1,
19,
5,
3,
27,
9,
3,
3,
100
] | 13 | true | Domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | DNA-dir_RNAP_su2_dom | 3 |
IPR007121 | 7,121 | RNA polymerase, beta subunit, conserved site | RNA_pol_bsu_CS | Conserved_site | 68,164 | false | false | RNA polymerases ( ) catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [ ]. The hybrid-binding domain binds the nasc... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS01166"
] | [
"RNA_POL_BETA"
] | [
68164
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"PDOC00896",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
... | [
"EC:2.7.7.6",
"PROSITEDOC:PDOC00896",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",... | 215 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,213 | [
"PUB00008731"
] | [
"11313498"
] | [
"Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1208,
29282,
36376,
546,
752
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
27,
3,
4,
4,
1,
18,
4,
3,
26,
9,
3,
3,
76
] | 13 | true | Conserved_site | RNA polymerase, beta subunit, conserved site | RNA polymerase, beta subunit, conserved site | RNA_pol_bsu_CS | 6 |
IPR007122 | 7,122 | Villin/Gelsolin | Villin/Gelsolin | Family | 27,718 | false | false | Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [ , ]. It can be regulated by Ca2+ and phosphoinositides [ ]. The interaction between gelsolin and tropomyosin modulates actin dynami... | [
"GO:0051015"
] | [
"actin filament binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS",
"PANTHER",
"SMART"
] | [
"PR00597",
"PTHR11977",
"SM00262"
] | [
"GELSOLIN",
"",
"GEL"
] | [
20762,
26740,
26452
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-264870",
"R-CEL-6798695",
"R-DDI-6798695",
"R-DME-264870",
"R-DME-6798695",
"R-HSA-264870",
"R-HSA-6798695",
"R-HSA-9662361",
"R-HSA-977225",
"R-MMU-264870",
"R-MMU-6798695",
"R-RNO-264870",
"R-RNO-6798695",
"R-SSC-264870",
"R-SSC-6798695"
] | [
"REACTOME:R-CEL-264870",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-264870",
"REACTOME:R-DME-6798695",
"REACTOME:R-HSA-264870",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9662361",
"REACTOME:R-HSA-977225",
"REACTOME:R-MMU-264870",
"REACTOME:R-MMU-6798695",
"REACTOME:R-R... | 15 | [
"1c0f",
"1c0g",
"1d0n",
"1d4x",
"1dej",
"1eqy",
"1esv",
"1h1v",
"1j72",
"1jhw",
"1kcq",
"1mdu",
"1nlv",
"1nm1",
"1nmd",
"1nph",
"1p8x",
"1p8z",
"1rgi",
"1svq",
"1svr",
"1svy",
"1t44",
"1yag",
"1yvn",
"2ff3",
"2ff6",
"2fgh",
"2fh1",
"2fh2",
"2fh3",
"2fh4"... | 112 | [
"PUB00000950",
"PUB00001347",
"PUB00003232",
"PUB00014646",
"PUB00019609",
"PUB00034915",
"PUB00034916",
"PUB00071423",
"PUB00071424",
"PUB00071425",
"PUB00071430"
] | [
"9288746",
"3023087",
"2850369",
"2256904",
"15526166",
"3087992",
"287075",
"14527663",
"23844991",
"20393563",
"3027569"
] | [
"The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.",
"Preparation and characterization of pig plasma and platelet gelsolins.",
"Nucleotide sequence of pig plasma gelsolin. Comparison of protein sequence with human gelsolin and other actin-severing proteins shows... | [
1997,
1986,
1988,
1990,
2004,
1986,
1979,
2003,
2013,
2010,
1987
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Klosneuvirinae",
"Promethearchaeati",
"marine sediment metagenome"
] | [
27693,
2,
9,
14
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
35,
3,
181,
14,
65,
48,
1,
12,
37,
160
] | 10 | true | Family | Villin/Gelsolin | Villin/Gelsolin | Villin/Gelsolin | 6 |
IPR007123 | 7,123 | Gelsolin-like domain | Gelsolin-like_dom | Domain | 45,685 | false | false | Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that binds to the barbed ends of actin filaments, preventing monomer exchange (end-blocking or capping) [ ]. It can promote nucleation (the assembly of monomers into filaments), as well as sever existing filaments. In addition, this protein binds wi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00626"
] | [
"Gelsolin"
] | [
45685
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-204005",
"R-BTA-2132295",
"R-BTA-5694530",
"R-BTA-983170",
"R-CEL-264870",
"R-CEL-6798695",
"R-DDI-204005",
"R-DDI-5694530",
"R-DDI-6798695",
"R-DDI-983170",
"R-DME-264870",
"R-DME-6798695",
"R-DRE-204005",
"R-DRE-2132295",
"R-DRE-983170",
"R-HSA-1655829",
"R-HSA-204005",
"R... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-5694530",
"REACTOME:R-BTA-983170",
"REACTOME:R-CEL-264870",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-5694530",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-983170",
"REACTOME:R-DME-264870",
"REACTOME:R-DM... | 44 | [
"1c0f",
"1c0g",
"1d0n",
"1d4x",
"1dej",
"1eqy",
"1esv",
"1h1v",
"1j72",
"1jhw",
"1kcq",
"1m2o",
"1m2v",
"1mdu",
"1nlv",
"1nm1",
"1nmd",
"1nph",
"1p8x",
"1p8z",
"1pcx",
"1pd0",
"1pd1",
"1rgi",
"1svq",
"1svr",
"1svy",
"1t44",
"1yag",
"1yvn",
"2ff3",
"2ff6"... | 148 | [
"PUB00001347",
"PUB00003232"
] | [
"3023087",
"2850369"
] | [
"Preparation and characterization of pig plasma and platelet gelsolins.",
"Nucleotide sequence of pig plasma gelsolin. Comparison of protein sequence with human gelsolin and other actin-severing proteins shows strong homologies and evidence for large internal repeats."
] | [
1986,
1988
] | 2 | [] | [
"IPR037550"
] | 0 | 1 | 0 | [
"Eukaryota",
"Klosneuvirinae",
"Promethearchaeati",
"marine sediment metagenome"
] | [
45646,
2,
10,
27
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
76,
4,
200,
18,
83,
66,
3,
33,
61,
4,
4,
236
] | 12 | true | Domain | Gelsolin-like domain | Gelsolin-like domain | Gelsolin-like_dom | 8 |
IPR007125 | 7,125 | Core Histone H2A/H2B/H3 domain | H2A/H2B/H3 | Domain | 117,589 | false | false | Five major families of histones exist: H1/H5, H2A, H2B, H3, and H4 [ ]. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. The core histones together with some other DNA binding proteins form a superfamily defined by a common fold and distant sequence... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00125"
] | [
"Histone"
] | [
117589
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110330",
"R-BTA-110331",
"R-BTA-1266695",
"R-BTA-171306",
"R-BTA-201722",
"R-BTA-212300",
"R-BTA-2299718",
"R-BTA-2559580",
"R-BTA-2559582",
"R-BTA-2559586",
"R-BTA-3214815",
"R-BTA-3214841",
"R-BTA-3214842",
"R-BTA-3214847",
"R-BTA-3214858",
"R-BTA-3247509",
"R-BTA-427359",
... | [
"REACTOME:R-BTA-110330",
"REACTOME:R-BTA-110331",
"REACTOME:R-BTA-1266695",
"REACTOME:R-BTA-171306",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2559582",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-3214815",
"REACTOME:R-B... | 355 | [
"1aoi",
"1eqz",
"1f66",
"1hio",
"1hq3",
"1id3",
"1kx3",
"1kx4",
"1kx5",
"1m18",
"1m19",
"1m1a",
"1n1j",
"1p34",
"1p3a",
"1p3b",
"1p3f",
"1p3g",
"1p3i",
"1p3k",
"1p3l",
"1p3m",
"1p3o",
"1p3p",
"1s32",
"1tzy",
"1u35",
"1zbb",
"1zla",
"2aro",
"2cv5",
"2f8n"... | 1,044 | [
"PUB00004260",
"PUB00005743",
"PUB00005777",
"PUB00066796",
"PUB00094278"
] | [
"9305837",
"7651829",
"9016552",
"16472024",
"26542958"
] | [
"Crystal structure of the nucleosome core particle at 2.8 A resolution.",
"A variety of DNA-binding and multimeric proteins contain the histone fold motif.",
"Histone and histone fold sequences and structures: a database.",
"Recognition and classification of histones using support vector machine.",
"OsNF-YC... | [
1997,
1995,
1997,
2006,
2016
] | 5 | [] | [
"IPR061508"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
9,
10,
117490,
53,
27
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
126,
23,
74,
10,
98,
87,
6,
82,
107,
8,
8,
204
] | 12 | true | Domain | Core Histone H2A/H2B/H3 domain | Core Histone H2A/H2B/H3 domain | H2A/H2B/H3 | 9 |
IPR007126 | 7,126 | Borrelia REV | Borrelia_REV | Family | 45 | false | false | This family consists of several REV proteins from Borrelia burgdorferi (Lyme disease spirochete) and Borrelia garinii. The function of REV is unknown although it has been shown that the gene is induced during the ingesting of host blood suggesting a role in the metabolic activation of borreliae to adapt to physiologica... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM",
"PIRSF"
] | [
"NF033731",
"PF03978",
"PIRSF020372"
] | [
"borfam63",
"Borrelia_REV",
"Borrelia_REV"
] | [
43,
45,
39
] | 3 | [] | [] | [] | 0 | [
"5eqz"
] | 1 | [
"PUB00016651"
] | [
"11580974"
] | [
"Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
45
] | 1 | [] | [] | 0 | true | Family | Borrelia REV | Borrelia REV | Borrelia_REV | 3 |
IPR007127 | 7,127 | RNA polymerase sigma factor 70, region 1.1 | RNA_pol_sigma_70_r1_1 | Domain | 18,484 | false | false | The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th... | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF03979"
] | [
"Sigma70_r1_1"
] | [
18484
] | 1 | [] | [] | [] | 0 | [
"2k6x",
"3iyd",
"4jk1",
"4jk2",
"4jkr",
"4kmu",
"4kn4",
"4kn7",
"4lk1",
"4llg",
"4mex",
"4mey",
"4yfk",
"4yfn",
"4yfx",
"4yg2",
"4yln",
"4ylo",
"4ylp",
"4zh2",
"4zh3",
"4zh4",
"5mww",
"5uac",
"5uag",
"5uah",
"5uaj",
"5ual",
"5uaq",
"5vsw",
"5w1s",
"5w1t"... | 115 | [
"PUB00000061",
"PUB00002181",
"PUB00004340",
"PUB00009791",
"PUB00010576",
"PUB00088319",
"PUB00097431"
] | [
"3052291",
"1597408",
"3092189",
"10613885",
"9927430",
"25596450",
"23389035"
] | [
"Structure and function of bacterial sigma factors.",
"The sigma 70 family: sequence conservation and evolutionary relationships.",
"Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.",
"Effects of amino acid substitutions at conserved and acidic residues within region ... | [
1988,
1992,
1986,
2000,
1999,
2015,
2013
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloferax litoreum",
"Peduoviridae",
"unclassified sequences"
] | [
18211,
32,
1,
2,
238
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | RNA polymerase sigma factor 70, region 1.1 | RNA polymerase sigma factor 70, region 1.1 | RNA_pol_sigma_70_r1_1 | 4 |
IPR007128 | 7,128 | Nuclear MIS12/MIND complex subunit PMF1/Nnf1 | PMF1/Nnf1 | Family | 3,823 | false | false | This entry includes polyamine-modulated factor 1 (PMF1) from animals and Nnf1 from yeasts. PMF1 is part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis [ ]. Nnf1 is an essential component of the MIND kinetochore complex required for accurat... | [
"GO:0000444"
] | [
"MIS12/MIND type complex"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF03980",
"PTHR15459"
] | [
"Nnf1",
""
] | [
3242,
3361
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-141444",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-5663220",
"R-BTA-68877",
"R-BTA-9648025",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R... | [
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-5663220",
"REACTOME:R-BTA-68877",
"REACTOME:R-BTA-9648025",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HS... | 18 | [
"5lsj",
"5lsk",
"5t51",
"5t58",
"5t59",
"5wwl",
"8ppr",
"8q5h"
] | 8 | [
"PUB00017334",
"PUB00074622"
] | [
"12455957",
"16585270"
] | [
"Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.",
"The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation."
] | [
2002,
2006
] | 2 | [] | [
"IPR016851"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
3823
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
7,
1,
1,
3,
3,
2,
3,
6,
1,
2,
7
] | 11 | true | Family | Nuclear MIS12/MIND complex subunit PMF1/Nnf1 | Nuclear MIS12/MIND complex subunit PMF1/Nnf1 | PMF1/Nnf1 | 8 |
IPR007129 | 7,129 | Ubiquinol-cytochrome c chaperone, CBP3 | Ubiqinol_cyt_c_chaperone_CPB3 | Family | 6,106 | false | false | Saccharomyces cerevisiae ubiquinol-cytochrome C chaperone (known as CBP3) is required for assembly of coenzyme QF-2-cytochrome C reductase. The crystal structure of this protein has been resolved in the homologue from the bacteria Brucella abortus, showing an all-helical fold [ ]. Homologues are found in a number of di... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12184"
] | [
""
] | [
6106
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9865881",
"R-SCE-9865878"
] | [
"REACTOME:R-HSA-9865881",
"REACTOME:R-SCE-9865878"
] | 2 | [
"6rwt"
] | 1 | [
"PUB00087488",
"PUB00100678"
] | [
"24385928",
"31537648"
] | [
"Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.",
"Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome <i>b</i> during mitochondrial respiratory chain assembly."
] | [
2013,
2019
] | 2 | [] | [
"IPR014569"
] | 0 | 1 | 0 | [
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
4601,
1490,
15
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
1,
13,
7,
1,
3,
8,
1,
1,
12
] | 12 | true | Family | Ubiquinol-cytochrome c chaperone, CBP3 | Ubiquinol-cytochrome c chaperone, CBP3 | Ubiqinol_cyt_c_chaperone_CPB3 | 3 |
IPR007130 | 7,130 | Diacylglycerol acyltransferase | DAGAT | Family | 15,570 | false | false | This family includes diacylglycerol acyltransferases which catalyse the terminal and only committed step in triacylglycerol (TAG) synthesis using diacylglycerol (DAG) and fatty acyl-CoA as substrates. It is required for synthesis and storage of intracellular triglycerides [ , , , , ]. In yeast, it is involved in lipid ... | [
"GO:0008374"
] | [
"O-acyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03982"
] | [
"DAGAT"
] | [
15570
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"2.3.1",
"2.3.1.20",
"R-BTA-75109",
"R-DDI-1482883",
"R-DDI-2142753",
"R-DDI-2187335",
"R-DDI-75109",
"R-DDI-9640463",
"R-DRE-1482883",
"R-DRE-2142753",
"R-DRE-2187335",
"R-DRE-75109",
"R-DRE-9640463",
"R-HSA-1482883",
"R-HSA-2142753",
"R-HSA-2187335",
"R-HSA-75109",
"R-HSA-9640463... | [
"EC:2.3.1",
"EC:2.3.1.20",
"REACTOME:R-BTA-75109",
"REACTOME:R-DDI-1482883",
"REACTOME:R-DDI-2142753",
"REACTOME:R-DDI-2187335",
"REACTOME:R-DDI-75109",
"REACTOME:R-DDI-9640463",
"REACTOME:R-DRE-1482883",
"REACTOME:R-DRE-2142753",
"REACTOME:R-DRE-2187335",
"REACTOME:R-DRE-75109",
"REACTOME:R... | 36 | [] | 0 | [
"PUB00009790",
"PUB00010588",
"PUB00055421",
"PUB00099607",
"PUB00099608",
"PUB00099609",
"PUB00099610",
"PUB00099611",
"PUB00100302"
] | [
"11751830",
"11751875",
"12963726",
"26990381",
"27184406",
"28420705",
"15671038",
"24799687",
"22623494"
] | [
"Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae.",
"The DGA1 gene determines a second triglyceride synthetic pathway in yeast.",
"Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo a... | [
2002,
2002,
2003,
2016,
2016,
2017,
2005,
2014,
2012
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Yasminevirus sp. GU-2018",
"metagenomes"
] | [
301,
15252,
1,
16
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
39,
5,
15,
4,
12,
12,
1,
16,
21,
1,
1,
42
] | 12 | true | Family | Diacylglycerol acyltransferase | Diacylglycerol acyltransferase | DAGAT | 7 |
IPR007132 | 7,132 | Protein of unknown function DUF346 | DUF346 | Repeat | 190 | false | false | This repeat is found as seven tandem copies in carbohydrate-binding proteins, including Fucose-binding Lectin from Photorhabdus laumondii ( )and similar fungal and bacterial proteins. It is composed of β-strands and forms a seven-bladed β-propeller structure [ , ]. It is found in association with BNR repeats, which als... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03984"
] | [
"DUF346"
] | [
190
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100843",
"PUB00100844"
] | [
"27758853",
"33765407"
] | [
"A Novel Fucose-binding Lectin from Photorhabdus luminescens (PLL) with an Unusual Heptabladed β-Propeller Tetrameric Structure.",
"Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions."
] | [
2016,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanosarcina vacuolata Z-761",
"leotiomyceta"
] | [
157,
1,
32
] | 3 | [] | [] | 0 | true | Repeat | Protein of unknown function DUF346 | Protein of unknown function DUF346 | DUF346 | 9 |
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