interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR007133 | 7,133 | RNA polymerase II associated factor Paf1 | RNA_pol_II-assoc_Paf1 | Family | 4,518 | false | false | In budding yeasts, Paf1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1 [ ]. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [ ]. | [
"GO:0006368",
"GO:0016593"
] | [
"transcription elongation by RNA polymerase II",
"Cdc73/Paf1 complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF03985",
"PTHR23188"
] | [
"Paf1",
""
] | [
4472,
4343
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-674695",
"R-BTA-75955",
"R-BTA-8866654",
"R-CEL-112382",
"R-CEL-674695",
"R-CEL-75955",
"R-HSA-112382",
"R-HSA-674695",
"R-HSA-75955",
"R-HSA-8866654",
"R-MMU-112382",
"R-MMU-674695",
"R-MMU-75955",
"R-MMU-8866654",
"R-RNO-112382",
"R-RNO-674695",
"R-RNO-75955",
"R-RNO-88666... | [
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-75955",
"REACTOME:R-BTA-8866654",
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-75955",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-674695",
"REACTOME:R-HSA-75955",
"REACTOME:R-HSA-8866654",
"REACTOME:R-MMU-112382",
"REACTOME:R-MMU-6746... | 22 | [
"4m6t",
"5zyp",
"5zyq",
"6af0",
"6gmh",
"6ted",
"7dkh",
"7oop",
"7opc",
"7opd",
"7unc",
"7und",
"7xn7",
"7xse",
"7xsx",
"7xsz",
"7xt7",
"7xtd",
"7xti",
"8a3y",
"8j8p",
"8j8q",
"9egx",
"9egy",
"9egz",
"9eh0",
"9eh1",
"9eh2",
"9hvq",
"9rtt",
"9s0u",
"9s3g"... | 32 | [
"PUB00009800",
"PUB00074568",
"PUB00074570",
"PUB00074574",
"PUB00074575",
"PUB00074589"
] | [
"11884586",
"20178742",
"1913663",
"16491129",
"22419161",
"21799800"
] | [
"Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex.",
"The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.",
"Workshop report from the Division of Research Grants, National Institutes of Health. The role of chromosome rea... | [
2002,
2010,
1991,
2006,
2012,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4518
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
3,
3,
1,
1,
3,
2,
1,
1,
21
] | 12 | true | Family | RNA polymerase II associated factor Paf1 | RNA polymerase II associated factor Paf1 | RNA_pol_II-assoc_Paf1 | 5 |
IPR007135 | 7,135 | Ubiquitin-like-conjugating enzyme Atg3/Atg10 | Atg3/Atg10 | Family | 8,893 | false | false | This entry represents a group of ubiquitin-like-conjugating enzymes, including Atg3 and Atg10. Atg3 is the E2 enzyme for the LC3 lipidation process [ ]. It is essential for autophagocytosis. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 ... | [
"GO:0019787"
] | [
"ubiquitin-like protein transferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03987"
] | [
"Autophagy_act_C"
] | [
8893
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1632852",
"R-DDI-1632852",
"R-HSA-1632852",
"R-MMU-1632852",
"R-PFA-1632852",
"R-RNO-1632852",
"R-SCE-1632852",
"R-SPO-1632852",
"R-XTR-1632852"
] | [
"REACTOME:R-BTA-1632852",
"REACTOME:R-DDI-1632852",
"REACTOME:R-HSA-1632852",
"REACTOME:R-MMU-1632852",
"REACTOME:R-PFA-1632852",
"REACTOME:R-RNO-1632852",
"REACTOME:R-SCE-1632852",
"REACTOME:R-SPO-1632852",
"REACTOME:R-XTR-1632852"
] | 9 | [
"2dyt",
"2lpu",
"3vx7",
"3vx8",
"4ebr",
"4gsk",
"4gsl",
"6ojj",
"8fkm",
"9e8p"
] | 10 | [
"PUB00043585",
"PUB00043586",
"PUB00043587",
"PUB00098078",
"PUB00108654",
"PUB00154406",
"PUB00154407"
] | [
"18321988",
"18398292",
"17227760",
"23255127",
"24191030",
"33446636",
"37252361"
] | [
"The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.",
"The Ubi brothers reunited.",
"The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.",
"An Atg10-like E2 enzyme is essential for cell cycle progre... | [
2008,
2008,
2007,
2013,
2013,
2021,
2023
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8893
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
3,
4,
3,
4,
3,
2,
14,
13,
2,
2,
19
] | 12 | true | Family | Ubiquitin-like-conjugating enzyme Atg3/Atg10 | Ubiquitin-like-conjugating enzyme Atg3/Atg10 | Atg3/Atg10 | 3 |
IPR007136 | 7,136 | Protein of unknown function DUF347 | DUF347 | Repeat | 4,453 | false | false | This repeat is found as four tandem repeats in a family of bacterial membrane proteins. Each repeat contains two transmembrane regions and a conserved tryptophan. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03988"
] | [
"DUF347"
] | [
4453
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5,
4353,
53,
42
] | 4 | [] | [] | 0 | true | Repeat | Protein of unknown function DUF347 | Protein of unknown function DUF347 | DUF347 | 7 |
IPR007137 | 7,137 | Resuscitation-promoting factor, domain of unknown function DUF348 | DUF348 | Domain | 6,402 | false | false | This domain normally occurs as tandem repeats. It is found in resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03990"
] | [
"DUF348"
] | [
6402
] | 1 | [] | [] | [] | 0 | [
"5e27"
] | 1 | [
"PUB00075582"
] | [
"19799629"
] | [
"Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eumeta variegata",
"unclassified sequences"
] | [
6359,
1,
42
] | 3 | [] | [] | 0 | true | Domain | Resuscitation-promoting factor, domain of unknown function DUF348 | Resuscitation-promoting factor, domain of unknown function DUF348 | DUF348 | 7 |
IPR007139 | 7,139 | Protein of unknown function DUF349 | DUF349 | Repeat | 8,577 | false | false | This motif is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three α-helices, and possibly a β-strand. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03993"
] | [
"DUF349"
] | [
8577
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
8325,
8,
1,
243
] | 4 | [] | [] | 0 | true | Repeat | Protein of unknown function DUF349 | Protein of unknown function DUF349 | DUF349 | 7 |
IPR007140 | 7,140 | Protein of unknown function DUF350 | DUF350 | Repeat | 9,401 | false | false | This motif occurs in a small set of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03994"
] | [
"DUF350"
] | [
9401
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Achromobacter phage Motura",
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1,
31,
9258,
14,
97
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Repeat | Protein of unknown function DUF350 | Protein of unknown function DUF350 | DUF350 | 5 |
IPR007142 | 7,142 | Haemagglutinin-esterase glycoprotein, core | Hemagglutn-estrase_core | Domain | 1,014 | false | false | Haemagglutinin-esterase fusion glycoprotein (HEF) is a multi-functional protein embedded in the viral envelope of several viruses, including influenza C virus, coronaviruses and toroviruses [ , ]. HEF is required for infectivity, and functions to recognise the host cell surface receptor, to fuse the viral and host cell... | [
"GO:0016788",
"GO:0046789",
"GO:0019064",
"GO:0019031"
] | [
"hydrolase activity, acting on ester bonds",
"host cell surface receptor binding",
"fusion of virus membrane with host plasma membrane",
"viral envelope"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF03996"
] | [
"Hema_esterase"
] | [
1014
] | 1 | [
"EC"
] | [
"3.1.1.53"
] | [
"EC:3.1.1.53"
] | 1 | [
"1flc",
"3cl4",
"3cl5",
"3i1k",
"3i1l",
"3i26",
"3i27",
"4c7l",
"4c7w",
"4zxn",
"5e5w",
"5e62",
"5e64",
"5e65",
"5e66",
"5jif",
"5jil",
"5n11",
"6y3y",
"6yi5"
] | 20 | [
"PUB00010667",
"PUB00033172"
] | [
"9817207",
"16575523"
] | [
"Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus.",
"Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses."
] | [
1998,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
1014
] | 1 | [] | [] | 0 | true | Domain | Haemagglutinin-esterase glycoprotein, core | Haemagglutinin-esterase glycoprotein, core | Hemagglutn-estrase_core | 9 |
IPR007143 | 7,143 | Vacuolar protein sorting-associated Vps28 | Vps28 | Family | 4,376 | false | false | The Endosomal Sorting Complex Required for Transport (ESCRT) complexes form the machinery driving protein sorting from endosomes to lysosomes. ESCRT complexes are central to receptor down-regulation, lysosome biogenesis, and budding of HIV. Yeast ESCRT-I consists of three protein subunits, Vps23, Vps28, and Vps37. In h... | [
"GO:0032509",
"GO:0000813"
] | [
"endosome transport via multivesicular body sorting pathway",
"ESCRT I complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF03997",
"PIRSF017535",
"PTHR12937"
] | [
"VPS28",
"VPS28",
""
] | [
4370,
3415,
4257
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-917729",
"R-CEL-917729",
"R-DDI-917729",
"R-DME-917729",
"R-HSA-162588",
"R-HSA-174490",
"R-HSA-917729",
"R-HSA-9610379",
"R-HSA-9615710",
"R-MMU-917729",
"R-RNO-917729",
"R-SCE-917729"
] | [
"REACTOME:R-BTA-917729",
"REACTOME:R-CEL-917729",
"REACTOME:R-DDI-917729",
"REACTOME:R-DME-917729",
"REACTOME:R-HSA-162588",
"REACTOME:R-HSA-174490",
"REACTOME:R-HSA-917729",
"REACTOME:R-HSA-9610379",
"REACTOME:R-HSA-9615710",
"REACTOME:R-MMU-917729",
"REACTOME:R-RNO-917729",
"REACTOME:R-SCE-9... | 12 | [
"2caz",
"2f66",
"2f6m",
"2g3k",
"2j9u",
"2j9v",
"2j9w",
"2p22",
"6vme"
] | 9 | [
"PUB00039953",
"PUB00040552"
] | [
"16615893",
"16615894"
] | [
"ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.",
"Structural and functional organization of the ESCRT-I trafficking complex."
] | [
2006,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paracoccus laeviglucosivorans",
"Promethearchaeati",
"unclassified sequences"
] | [
4359,
1,
3,
13
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
1,
2,
7,
3,
1,
2,
7,
1,
1,
6
] | 12 | true | Family | Vacuolar protein sorting-associated Vps28 | Vacuolar protein sorting-associated Vps28 | Vps28 | 1 |
IPR007144 | 7,144 | Small-subunit processome, Utp11 | SSU_processome_Utp11 | Family | 4,565 | false | false | A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA -the small-subunit (SSU) processome [ , ]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties: They are nucleolar. They are able to coimmunoprecipitate with ... | [
"GO:0006364",
"GO:0032040"
] | [
"rRNA processing",
"small-subunit processome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF03998",
"PIRSF015952",
"PTHR12838"
] | [
"Utp11",
"U3snoRNP11",
""
] | [
4563,
3265,
4440
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-PFA-6791226",
"R-RNO-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-PFA-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 10 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 45 | [
"PUB00008496",
"PUB00035836",
"PUB00035837"
] | [
"12068309",
"15590835",
"15489292"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"The small-subunit processome is a ribosome assembly intermediate.",
"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
] | [
2002,
2004,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4565
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
2,
1,
1,
1,
1,
2,
1,
1,
3,
1,
1,
15
] | 12 | true | Family | Small-subunit processome, Utp11 | Small-subunit processome, Utp11 | SSU_processome_Utp11 | 8 |
IPR007145 | 7,145 | Microtubule-associated protein, MAP65/Ase1/PRC1 | MAP65_Ase1_PRC1 | Family | 11,236 | false | false | This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals. Ase1 is required for spindle elongation and stabilisation. It is cell cycle-regulated by anaphase promoting complex [ ]. It is a potential Cdc28p substrate [ ]. | [
"GO:0008017",
"GO:0000226"
] | [
"microtubule binding",
"microtubule cytoskeleton organization"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR19321"
] | [
""
] | [
11236
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5625900",
"R-MMU-5625900"
] | [
"REACTOME:R-HSA-5625900",
"REACTOME:R-MMU-5625900"
] | 2 | [
"3nrx",
"3nry",
"4l3i",
"4l6y",
"5kmg"
] | 5 | [
"PUB00052582",
"PUB00062157",
"PUB00062159",
"PUB00062160",
"PUB00062161",
"PUB00062162",
"PUB00062163",
"PUB00062164",
"PUB00062165",
"PUB00062166",
"PUB00062167",
"PUB00062168",
"PUB00062169",
"PUB00077777"
] | [
"14574415",
"12591913",
"16014384",
"15908607",
"16098102",
"17011227",
"16847052",
"9885575",
"12082078",
"15297875",
"15625105",
"16431929",
"20691902",
"19468300"
] | [
"Targets of the cyclin-dependent kinase Cdk1.",
"The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.",
"Dynamic interaction of NtMAP65-1a with microtubules in vivo.",
"Two microtubule-associated proteins of the Arabidopsis MAP65 famil... | [
2003,
2003,
2005,
2005,
2005,
2006,
2006,
1998,
2002,
2004,
2005,
2006,
2010,
2009
] | 14 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11236
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
42,
1,
10,
4,
6,
8,
1,
43,
7,
1,
2,
122
] | 12 | true | Family | Microtubule-associated protein, MAP65/Ase1/PRC1 | Microtubule-associated protein, MAP65/Ase1/PRC1 | MAP65_Ase1_PRC1 | 6 |
IPR007147 | 7,147 | Transcription factor Vhr | TF_Vhr | Family | 207 | false | false | The Vhr1 family of budding yeast transcription factors consists of Vhr1 and Vhr2 [ ]. Vhr1 regulates the biotin-dependent expression of transporters VHT1 and BIO5 [ ]. Vhr2 regulates ERG9, but seems to have a more global function in transcription [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04001"
] | [
"Vhr1"
] | [
207
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045167",
"PUB00066185",
"PUB00066186"
] | [
"16533810",
"22189060",
"11342098"
] | [
"Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5.",
"Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights.",
"Positive and negative regulation of squalene synthase (ERG9), ... | [
2006,
2011,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
207
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2
] | 1 | true | Family | Transcription factor Vhr | Transcription factor Vhr | TF_Vhr | 3 |
IPR007148 | 7,148 | Small-subunit processome, Utp12 | SSU_processome_Utp12 | Domain | 13,643 | false | false | A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA -the small-subunit (SSU) processome [ , ]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties: They are nucleolar. They are able to coimmunoprecipitate with ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04003"
] | [
"Utp12"
] | [
13643
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 7 | [
"5ic9",
"5ica",
"5oql",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t"... | 51 | [
"PUB00008496",
"PUB00035836",
"PUB00035837"
] | [
"12068309",
"15590835",
"15489292"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"The small-subunit processome is a ribosome assembly intermediate.",
"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
] | [
2002,
2004,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
13643
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
24,
3,
4,
4,
6,
8,
3,
13,
9,
3,
4,
21
] | 12 | true | Domain | Small-subunit processome, Utp12 | Small-subunit processome, Utp12 | SSU_processome_Utp12 | 2 |
IPR007149 | 7,149 | Leo1-like protein | Leo1 | Family | 4,966 | false | false | In budding yeasts, Leo1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [ ]. | [
"GO:0006368",
"GO:0016593"
] | [
"transcription elongation by RNA polymerase II",
"Cdc73/Paf1 complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04004",
"PTHR23146"
] | [
"Leo1",
""
] | [
4885,
4907
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-112382",
"R-CEL-201722",
"R-CEL-674695",
"R-CEL-75955",
"R-DME-112382",
"R-DME-201722",
"R-DME-674695",
"R-DME-75955",
"R-DME-8866654",
"R-HSA-112382",
"R-HSA-201722",
"R-HSA-674695",
"R-HSA-75955",
"R-HSA-8866654",
"R-MMU-112382",
"R-MMU-201722",
"R-MMU-674695",
"R-MMU-7595... | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-201722",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-75955",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-201722",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-75955",
"REACTOME:R-DME-8866654",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-201722",
"REACTOME:R-HSA-6746... | 24 | [
"4m6t",
"6gmh",
"6ted",
"7oop",
"7opc",
"7opd",
"7unc",
"7und",
"7xn7",
"7xse",
"7xsx",
"7xsz",
"7xt7",
"7xtd",
"7xti",
"8a3y",
"9egx",
"9egy",
"9egz",
"9eh0",
"9eh1",
"9eh2",
"9hvq",
"9rtt",
"9s0u",
"9s3g"
] | 26 | [
"PUB00074568",
"PUB00074571",
"PUB00074589"
] | [
"20178742",
"15791002",
"21799800"
] | [
"The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.",
"Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.",
"Identification of the Arabidopsis REDUCED DORM... | [
2010,
2005,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4966
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
2,
2,
1,
1,
8,
5,
1,
1,
19
] | 12 | true | Family | Leo1-like protein | Leo1-like protein | Leo1 | 2 |
IPR007150 | 7,150 | HUS1/Mec3 | HUS1/Mec3 | Family | 4,666 | false | false | This entry consists of the human HUS1 protein and budding yeast Mec3. They are components of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes [ , ]. | [
"GO:0000077",
"GO:0030896"
] | [
"DNA damage checkpoint signaling",
"checkpoint clamp complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04005",
"PTHR12900"
] | [
"Hus1",
""
] | [
4664,
4451
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-176187",
"R-DME-176187",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"R-MMU-69473",
"R-... | [
"REACTOME:R-DDI-176187",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA... | 19 | [
"3a1j",
"3g65",
"3ggr",
"6j8y",
"7sgz",
"7sh2",
"7st9",
"7stb",
"7z6h",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8",
"8gnn",
"8wu8"
] | 18 | [
"PUB00060227",
"PUB00060228",
"PUB00062233",
"PUB00062256"
] | [
"9891048",
"9311982",
"9180692",
"21978893"
] | [
"Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.",
"The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.",
"Molecular analysis of hus1+, a fission yeast gene required for ... | [
1999,
1997,
1997,
2011
] | 4 | [] | [
"IPR016580"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
4666
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
7,
3,
1,
4,
4,
1,
1,
13
] | 12 | true | Family | HUS1/Mec3 | HUS1/Mec3 | HUS1/Mec3 | 1 |
IPR007152 | 7,152 | Protein of unknown function DUF354 | DUF354 | Family | 1,384 | false | false | Members of this family are around 350 amino acids in length. They are found in archaea and some bacteria and have no known function. This entry includes Uncharacterized protein MJ0665. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04007",
"PIRSF005357",
"PTHR39662"
] | [
"DUF354",
"UCP005357",
""
] | [
1297,
950,
1358
] | 3 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
933,
378,
73
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF354 | Protein of unknown function DUF354 | DUF354 | 3 |
IPR007153 | 7,153 | Adenosine specific kinase | Adenosine_kinase | Family | 1,316 | false | false | The structure of a member of this family from the hyperthermophilic archaeon Pyrobaculum aerophilum contains a modified histidine residue which is interpreted as stable phosphorylation. In vitro binding studies confirmed that adenosine and AMP but not ADP or ATP bind to the protein [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04008",
"PTHR36155"
] | [
"Adenosine_kin",
""
] | [
1316,
1307
] | 2 | [] | [] | [] | 0 | [
"1rlh",
"1vgg",
"1wvq",
"2d16",
"2ekm",
"2gl0",
"2jb7"
] | 7 | [
"PUB00041095"
] | [
"16737961"
] | [
"The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
270,
969,
35,
42
] | 4 | [] | [] | 0 | true | Family | Adenosine specific kinase | Adenosine specific kinase | Adenosine_kinase | 5 |
IPR007154 | 7,154 | Protein of unknown function DUF356 | DUF356 | Family | 194 | false | false | Members of this family are around 120 amino acids in length and are found in some archaebacteria. The function of this family is unknown. However it contains a conserved motif IHPPAH that may be involved in its function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04009",
"PIRSF006606"
] | [
"DUF356",
"UCP006606"
] | [
194,
174
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriota",
"metagenomes"
] | [
192,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF356 | Protein of unknown function DUF356 | DUF356 | 2 |
IPR007157 | 7,157 | PspA/VIPP1 | PspA_VIPP1 | Family | 18,782 | false | false | In Gram-negative organisms, PspA is part of the multi-gene Phage shock protein (Psp) response system that mitigates envelope damage by preventing proton leakage across a damaged membrane, thereby maintaining proton motive force [ ]. In Mycobacterium tuberculosis, PspA has been shown to integrate envelope stress-sensing... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04012",
"PTHR31088"
] | [
"PspA_IM30",
""
] | [
18580,
16340
] | 2 | [] | [] | [] | 0 | [
"4whe",
"6zvr",
"6zvs",
"6zvt",
"6zw4",
"6zw5",
"6zw6",
"6zw7",
"7abk",
"7o3w",
"7o3x",
"7o3y",
"7o3z",
"7o40",
"8akq",
"8akr",
"8aks",
"8akt",
"8aku",
"8akv",
"8akw",
"8akx",
"8aky",
"8akz",
"8al0",
"8qbr",
"8qbs",
"8qbv",
"8qbw",
"8qfv",
"8qhv",
"8qhw"... | 62 | [
"PUB00009806",
"PUB00095086",
"PUB00095109"
] | [
"12079332",
"25899163",
"27002134"
] | [
"Mechanism of action of the Escherichia coli phage shock protein PspA in repression of the AAA family transcription factor PspF.",
"The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.",
"Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeos... | [
2002,
2015,
2016
] | 3 | [] | [
"IPR014319"
] | 0 | 1 | 0 | [
"Ackermannviridae",
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7,
441,
16989,
1222,
123
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
2,
1,
19
] | 4 | true | Family | PspA/VIPP1 | PspA/VIPP1 | PspA_VIPP1 | 9 |
IPR007159 | 7,159 | SpoVT-AbrB domain | SpoVT-AbrB_dom | Domain | 56,258 | false | false | The SpoVT-AbrB domain is a DNA-binding domain found in a large protein superfamily [ , ], which includes: Bacterial antibiotic resistance protein B (AbrB), a transition-state regulator. Bacterial SpoVT, a late sporulation factor that modulates forespore-specific sigma G-dependent transcription. Bacterial PrlF, an antit... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART",
"NCBIFAM"
] | [
"PF04014",
"PS51740",
"SM00966",
"TIGR01439"
] | [
"MazE_antitoxin",
"SPOVT_ABRB",
"SpoVT_AbrB",
"lp_hng_hel_AbrB"
] | [
29484,
42173,
30591,
17754
] | 4 | [] | [] | [] | 0 | [
"1mvf",
"1n0e",
"1n0f",
"1n0g",
"1ub4",
"1yfb",
"1ysf",
"1z0r",
"2fy9",
"2glw",
"2k1n",
"2l66",
"2mrn",
"2mru",
"2ro3",
"2ro4",
"2ro5",
"2w1t",
"3o27",
"3tnd",
"3zvk",
"5itj",
"5itm",
"6ifm",
"6nkl",
"6sd6",
"7d2n",
"7d2p",
"7d2q",
"9h6a",
"9h6c",
"9h6d"... | 32 | [
"PUB00038491",
"PUB00038698"
] | [
"15939023",
"16223496"
] | [
"AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels.",
"Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins."
] | [
2005,
2005
] | 2 | [] | [
"IPR020603"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"IncL/M plasmid R446b",
"Viruses",
"unclassified sequences"
] | [
4605,
50346,
74,
1,
70,
1162
] | 6 | [
"Escherichia coli (strain K12)"
] | [
6
] | 1 | true | Domain | SpoVT-AbrB domain | SpoVT-AbrB domain | SpoVT-AbrB_dom | 9 |
IPR007160 | 7,160 | Domain of unknown function DUF362 | DUF362 | Domain | 7,218 | false | false | This domain is found in some iron-sulphur proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04015"
] | [
"DUF362"
] | [
7218
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
797,
5808,
40,
573
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF362 | Domain of unknown function DUF362 | DUF362 | 5 |
IPR007161 | 7,161 | Putative heavy-metal chelation domain | DUF364 | Domain | 2,331 | false | false | This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C terminus of proteins containing DUF4213 ( ). The structure of UniProtKB , PDB:3l5o, suggests that the protein has an ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04016"
] | [
"DUF364"
] | [
2331
] | 1 | [] | [] | [] | 0 | [
"3l5o",
"3npg"
] | 2 | [
"PUB00075371"
] | [
"20944207"
] | [
"Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
398,
1868,
65
] | 3 | [] | [] | 0 | true | Domain | Putative heavy-metal chelation domain | Putative heavy-metal chelation domain | DUF364 | 5 |
IPR007162 | 7,162 | Protein of unknown function DUF366 | DUF366 | Family | 310 | false | false | This is an archaeal family of unknown function, including Uncharacterized protein MJ0805 from Methanocaldococcus jannaschii. This protein has a BPL/LPL fold. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04017",
"PIRSF006503"
] | [
"DUF366",
"UCP006503"
] | [
310,
284
] | 2 | [] | [] | [] | 0 | [
"2ddz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
208,
93,
8,
1
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF366 | Protein of unknown function DUF366 | DUF366 | 2 |
IPR007163 | 7,163 | Undecaprenyl phosphate translocase-like | VCA0040-like | Family | 7,244 | false | false | This entry represents a group of prokaryotic proteins associated with transmembrane transport of undecaprenyl phosphate lipids, which is required for the biogenesis of microbial cell surface polymers, including from Vibrio cholerae (VCA0040) [ ]. Members of this family usually have between 6 and 9 predicted transmembra... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04018",
"PTHR37308"
] | [
"VCA0040-like",
""
] | [
7243,
7225
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103953"
] | [
"36450355"
] | [
"Undecaprenyl phosphate translocases confer conditional microbial fitness."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Microviridae sp. ctHN216",
"metagenomes"
] | [
472,
6657,
5,
1,
109
] | 5 | [] | [] | 0 | true | Family | Undecaprenyl phosphate translocase-like | Undecaprenyl phosphate translocase-like | VCA0040-like | 8 |
IPR007164 | 7,164 | GTP-dependent dephospho-CoA kinase | GTP-dep_dephospho-CoA_kin | Family | 1,053 | false | false | Dephospho-coenzyme A kinase (DPCK) catalyzes the ATP-dependent phosphorylation of dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis. This entry represents a group of DPCKs, including TK1697 from T. kodakarensis [ ]. | [
"GO:0016301",
"GO:0015937"
] | [
"kinase activity",
"coenzyme A biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER"
] | [
"MF_00590",
"PF04019",
"PIRSF006533",
"PTHR40732"
] | [
"Dephospho_CoA_kinase_GTP_dep",
"DUF359",
"UCP006533",
""
] | [
1007,
1051,
777,
1045
] | 4 | [
"EC",
"METACYC"
] | [
"2.7.1.237",
"PWY-8342"
] | [
"EC:2.7.1.237",
"METACYC:PWY-8342"
] | 2 | [
"8jvc",
"8jvf",
"8jvg"
] | 3 | [
"PUB00093757"
] | [
"31337720"
] | [
"Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
902,
113,
38
] | 3 | [] | [] | 0 | true | Family | GTP-dependent dephospho-CoA kinase | GTP-dependent dephospho-CoA kinase | GTP-dep_dephospho-CoA_kin | 2 |
IPR007165 | 7,165 | Mycobacterial 4 TMS phage holin, superfamily IV | Phage_holin_4_2 | Family | 14,106 | false | false | These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04020",
"PTHR37309"
] | [
"Phage_holin_4_2",
""
] | [
14105,
12378
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075704"
] | [
"23043507"
] | [
"Diversity in bacterial lysis systems: bacteriophages show the way."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Alveolata",
"Bacteria",
"Methanobacteriaceae",
"unclassified sequences"
] | [
2,
13893,
42,
169
] | 4 | [] | [] | 0 | true | Family | Mycobacterial 4 TMS phage holin, superfamily IV | Mycobacterial 4 TMS phage holin, superfamily IV | Phage_holin_4_2 | 2 |
IPR007166 | 7,166 | Class III signal peptide motif | Class3_signal_pept_motif | Conserved_site | 695 | false | false | This entry represents the class III signal peptide motif QXSXEXXXL found at the N-terminal in major and minor structural pili proteins in archaea. The Q residue is the +1 residue of the signal peptidase cleavage site [ ]. Two proteins containing this motif are cleaved by a type IV pilin-like signal peptidase. The archa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04021"
] | [
"Class_IIIsignal"
] | [
695
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044084",
"PUB00160387"
] | [
"17114255",
"21075925"
] | [
"Identification of diverse archaeal proteins with class III signal peptides cleaved by distinct archaeal prepilin peptidases.",
"Genetic and mass spectrometry analyses of the unusual type IV-like pili of the archaeon Methanococcus maripaludis."
] | [
2007,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
636,
52,
7
] | 3 | [] | [] | 0 | true | Conserved_site | Class III signal peptide motif | Class III signal peptide motif | Class3_signal_pept_motif | 5 |
IPR007167 | 7,167 | Ferrous iron transporter FeoA-like domain | Fe-transptr_FeoA-like | Domain | 28,589 | false | false | This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria. This domain also occurs at the C terminus in related proteins. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese. The transporter Feo is composed of t... | [
"GO:0046914"
] | [
"transition metal ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF04023",
"SM00899"
] | [
"FeoA",
"FeoA"
] | [
27648,
26250
] | 2 | [
"GP",
"REACTOME"
] | [
"GenProp1075",
"R-HSA-9638482"
] | [
"GP:GenProp1075",
"REACTOME:R-HSA-9638482"
] | 2 | [
"1fx7",
"1u8r",
"2gcx",
"2h3j",
"2k4y",
"2k5f",
"2k5i",
"2k5l",
"2lx9",
"3e19",
"3hrs",
"3hrt",
"3hru",
"3mhx",
"4o5v",
"4o6j",
"5cvi",
"5zr4",
"5zr6",
"6e55",
"6o5c",
"7b1v",
"7b1y",
"7b20",
"7b23",
"7b24",
"7b25",
"7r7b"
] | 28 | [
"PUB00009526",
"PUB00035969",
"PUB00064151"
] | [
"8407793",
"16718600",
"23104801"
] | [
"Characterization of the ferrous iron uptake system of Escherichia coli.",
"Feo--transport of ferrous iron into bacteria.",
"Solution structure of Escherichia coli FeoA and its potential role in bacterial ferrous iron transport."
] | [
1993,
2006,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"unclassified Caudoviricetes"
] | [
1254,
26859,
42,
432,
2
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Ferrous iron transporter FeoA-like domain | Ferrous iron transporter FeoA-like domain | Fe-transptr_FeoA-like | 5 |
IPR007168 | 7,168 | Phage shock protein, PspC, N-terminal | Phageshock_PspC_N | Domain | 25,396 | false | false | This domain is found in Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04024"
] | [
"PspC"
] | [
25396
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
201,
24992,
4,
2,
197
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Phage shock protein, PspC, N-terminal | Phage shock protein, PspC, N-terminal | Phageshock_PspC_N | 2 |
IPR007170 | 7,170 | Stage V sporulation protein G | SpoVG | Family | 4,222 | false | false | This entry represents the stage V sporulation protein G (SpoVG). It is essential for sporulation and specific to stage V sporulation in Bacillus megaterium and Bacillus subtilis [ ]. In B. subtilis, expression decreases after 30-60 minutes of cold shock [ ]. | [
"GO:0030435"
] | [
"sporulation resulting in formation of a cellular spore"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_00819",
"PF04026",
"PTHR38429"
] | [
"SpoVG",
"SpoVG",
""
] | [
2938,
4220,
4025
] | 3 | [] | [] | [] | 0 | [
"2i9x",
"2i9z",
"2ia9"
] | 3 | [
"PUB00009812",
"PUB00009813"
] | [
"1373326",
"8755892"
] | [
"spoVG sequence of Bacillus megaterium and Bacillus subtilis.",
"Cold shock stress-induced proteins in Bacillus subtilis."
] | [
1992,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaeoglobaceae",
"Bacteria",
"Sar",
"Viruses",
"unclassified sequences"
] | [
16,
4118,
3,
12,
73
] | 5 | [] | [] | 0 | true | Family | Stage V sporulation protein G | Stage V sporulation protein G | SpoVG | 9 |
IPR007171 | 7,171 | Protein of unknown function DUF371 | DUF371 | Family | 827 | false | false | This entry represents Uncharacterized protein MJ0206 and similar mainly archaeal proteins. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04027",
"PTHR40696"
] | [
"DUF371",
""
] | [
827,
815
] | 2 | [] | [] | [] | 0 | [
"3cbn",
"7y7n"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
753,
46,
28
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF371 | Protein of unknown function DUF371 | DUF371 | 9 |
IPR007172 | 7,172 | Domain of unknown function DUF374 | DUF374 | Domain | 3,082 | false | false | This is a bacterial domain of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF04028",
"cd07983"
] | [
"DUF374",
"LPLAT_DUF374-like"
] | [
3082,
2567
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2965,
5,
112
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF374 | Domain of unknown function DUF374 | DUF374 | 7 |
IPR007173 | 7,173 | D-arabinono-1,4-lactone oxidase, C-terminal domain | ALO_C | Domain | 17,703 | false | false | This domain is found at the C-terminal of the fungal protein D-arabinono-1,4-lactone oxidase , which is involved in the final step of the biosynthesis pathway of D-erythroascorbic acid, an important antioxidant and one of the virulence factors [ , ]. L-gulonolactone oxidase transforms L-gulono-1,4-lactone to L-xylo-hex... | [
"GO:0003885",
"GO:0016020"
] | [
"D-arabinono-1,4-lactone oxidase activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04030"
] | [
"ALO"
] | [
17703
] | 1 | [
"EC"
] | [
"1.1.3"
] | [
"EC:1.1.3"
] | 1 | [
"2vfr",
"2vfs",
"2vft",
"2vfu",
"2vfv",
"4aut",
"4f4q",
"4fdn",
"4fdo",
"4fdp",
"4feh",
"4ff6",
"4g3t",
"4g3u",
"4kw5",
"4ncr",
"4p8c",
"4p8h",
"4p8k",
"4p8l",
"4p8m",
"4p8n",
"4p8p",
"4p8t",
"4p8y",
"4pfa",
"4pfd",
"5oel",
"5oep",
"5oeq",
"6g83",
"6hez"... | 43 | [
"PUB00010580",
"PUB00074288",
"PUB00100405",
"PUB00100406",
"PUB00100407",
"PUB00100408"
] | [
"10094636",
"20622436",
"14962674",
"11349062",
"17517896",
"16956367"
] | [
"D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.",
"The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid.",
"Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of m... | [
1998,
2010,
2004,
2001,
2007,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
31,
10507,
7014,
13,
138
] | 5 | [
"Arabidopsis thaliana",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea may... | [
30,
3,
1,
25,
3,
1,
1,
36
] | 8 | true | Domain | D-arabinono-1,4-lactone oxidase, C-terminal domain | D-arabinono-1,4-lactone oxidase, C-terminal domain | ALO_C | 6 |
IPR007175 | 7,175 | Ribonuclease P subunit, Rpr2/Snm1/Rpp21 | Rpr2/Snm1/Rpp21 | Family | 5,364 | false | false | This entry contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) [ , ]. Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five protei... | [
"GO:0006396"
] | [
"RNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04032"
] | [
"Rpr2"
] | [
5364
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.26.5",
"R-HSA-6784531",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:3.1.26.5",
"REACTOME:R-HSA-6784531",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 4 | [
"1x0t",
"2k3r",
"2ki7",
"2zae",
"6agb",
"6ah3",
"6ahr",
"6ahu",
"6k0a",
"6k0b",
"6w6v",
"7c79",
"7c7a"
] | 13 | [
"PUB00006321",
"PUB00007201",
"PUB00010581",
"PUB00017140",
"PUB00068031",
"PUB00097410",
"PUB00097413",
"PUB00100655"
] | [
"7731988",
"10024167",
"11497433",
"10523674",
"11880623",
"16829535",
"28715256",
"30262633"
] | [
"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.",
"Rpp14 and Rpp29, two protein subunits of human ribonuclease P.",
"Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P.",
"Mutagenesis of SNM1, which encodes a protein component... | [
1995,
1999,
2001,
1999,
2002,
2006,
2017,
2018
] | 8 | [] | [
"IPR016432"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
856,
3,
4481,
24
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
1,
3,
14,
2,
2,
4,
3,
2,
2,
4
] | 11 | true | Family | Ribonuclease P subunit, Rpr2/Snm1/Rpp21 | Ribonuclease P subunit, Rpr2/Snm1/Rpp21 | Rpr2/Snm1/Rpp21 | 2 |
IPR007176 | 7,176 | Protein of unknown function DUF365 | DUF365 | Family | 78 | false | false | This is an archaeal family of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04033",
"PIRSF006031"
] | [
"DUF365",
"UCP006031"
] | [
78,
41
] | 2 | [] | [] | [] | 0 | [
"2kku"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Anncaliia algerae PRA339",
"Archaea",
"hydrocarbon metagenome"
] | [
1,
75,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF365 | Protein of unknown function DUF365 | DUF365 | 2 |
IPR007177 | 7,177 | 16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal | Tsr3_C | Domain | 5,310 | false | false | This domain can be found in the eukaryotic ribosome biogenesis protein Tsr3, which is involved in ribosomal RNA biogenesis [ ]. This domain is also found in the C terminus of Tsr3 homologues from archaea. It is usually associated with a putative metal-binding region in RNase L inhibitor, RLI ( ). Tsr3 from fungi and an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04034"
] | [
"Ribo_biogen_C"
] | [
5310
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"2.5.1.157",
"PWY-8341",
"R-HSA-6790901"
] | [
"EC:2.5.1.157",
"METACYC:PWY-8341",
"REACTOME:R-HSA-6790901"
] | 3 | [
"5ap8",
"5apg"
] | 2 | [
"PUB00076727",
"PUB00094251"
] | [
"25566315",
"27084949"
] | [
"Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis.",
"Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans."
] | [
2014,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Planctomycetia",
"unclassified sequences"
] | [
772,
4500,
5,
33
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
1,
7,
1,
4,
4,
1,
1,
6
] | 12 | true | Domain | 16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal | 16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal | Tsr3_C | 3 |
IPR007178 | 7,178 | Transcription elongation factor Spt4, archaea | Spt4_arch | Family | 918 | false | false | This entry represents Spt4 from Sulfolobus acidocaldarius (also known as RpoE2) and similar sequences mainly found in archaea. Spt4, of about 64 amino acids, forms a heterodimer with Spt5. The Spt4/5 heterodimer is considered a transcription elongation factor, responsible for making the archaeal DNA-directed RNA polyme... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"NCBIFAM",
"PANTHER"
] | [
"MF_00949",
"NF041664",
"PTHR40704"
] | [
"Spt4_arch",
"RNAP_arch_Epp",
""
] | [
899,
918,
917
] | 3 | [] | [] | [] | 0 | [
"1ryq",
"3lpe",
"3p8b",
"3qqc",
"4zn1",
"4zn3",
"8oki",
"8p2i",
"9bct",
"9bcu"
] | 10 | [
"PUB00010582",
"PUB00059148",
"PUB00059149",
"PUB00061569",
"PUB00068843",
"PUB00152956"
] | [
"8127719",
"19419240",
"19880312",
"20197319",
"21386817",
"28248297"
] | [
"A subunit of an archaeal DNA-dependent RNA polymerase contains the S1 motif.",
"Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure.",
"Archaeal RNA polymerase.",
"Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.",
"Architecture... | [
1994,
2009,
2009,
2010,
2011,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria candidate phyla",
"Palpitomonas bilix",
"unclassified sequences"
] | [
876,
2,
1,
39
] | 4 | [] | [] | 0 | true | Family | Transcription elongation factor Spt4, archaea | Transcription elongation factor Spt4, archaea | Spt4_arch | 1 |
IPR007180 | 7,180 | Domain of unknown function DUF382 | DUF382 | Domain | 5,062 | false | false | This domain is specific to the human splicing factor 3b subunit 2 and its orthologs. | [
"GO:0005634"
] | [
"nucleus"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04037"
] | [
"DUF382"
] | [
5062
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165"
] | 4 | [
"5gm6",
"5nrl",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ff4",
"6ff7",
"6g90",
"6qx9",
"6y50",
"6y53",
"6y5q",
"7abg",
"7abh",
"7abi",
"7dco",
"7dvq",
"7evo",
"7onb",
"7oqb",
"7oqe",
"7q3l",
"7q4o",
"7q4p",
"7qtt",
"7vpx",
"8ch6",
"8h6e"... | 51 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
5061,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
1,
3,
1,
1,
2,
2,
1,
1,
15
] | 12 | true | Domain | Domain of unknown function DUF382 | Domain of unknown function DUF382 | DUF382 | 5 |
IPR007181 | 7,181 | Dihydroneopterin aldolase MtpD, C-terminal domain | MtpD_C | Domain | 659 | false | false | This domain contains a strongly conserved YPLM motif and it is found at the C terminus of archaeal specific 7,8-dihydroneopterin aldolase (DHNA) MtpD, an enzyme involved in the synthesis of 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) [ ]. 6-HMDP is the precursor of the pterin containing moiety of the essenti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04038"
] | [
"DHNA"
] | [
659
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.1.2.25",
"PWY-6147",
"PWY-6148",
"PWY-6797",
"PWY-7539"
] | [
"EC:4.1.2.25",
"METACYC:PWY-6147",
"METACYC:PWY-6148",
"METACYC:PWY-6797",
"METACYC:PWY-7539"
] | 5 | [
"2i52",
"2iec",
"2ogf"
] | 3 | [
"PUB00061602"
] | [
"22931285"
] | [
"Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of methanopterin and tetrahydrofolate."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
630,
29
] | 2 | [] | [] | 0 | true | Domain | Dihydroneopterin aldolase MtpD, C-terminal domain | Dihydroneopterin aldolase MtpD, C-terminal domain | MtpD_C | 2 |
IPR007182 | 7,182 | Na+/H+ antiporter MnhB subunit-related protein | MnhB | Domain | 14,135 | false | false | This domain is found a subunit of the Na + /H + antiporter [ , , ], as well as in the bacterial NADH dehydrogenase subunit. Usually four transmembrane regions are found in this domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04039"
] | [
"MnhB"
] | [
14135
] | 1 | [] | [] | [] | 0 | [
"6cfw",
"6u8y",
"6z16",
"7d3u",
"7qru"
] | 5 | [
"PUB00009819",
"PUB00010583",
"PUB00057356"
] | [
"11356194",
"9852009",
"17293423"
] | [
"Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters.",
"A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus.",
"Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/pr... | [
2001,
1998,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
858,
13098,
15,
164
] | 4 | [] | [] | 0 | true | Domain | Na+/H+ antiporter MnhB subunit-related protein | Na+/H+ antiporter MnhB subunit-related protein | MnhB | 6 |
IPR007183 | 7,183 | Uncharacterised protein family UPF0280 | UPF0280 | Family | 1,231 | false | false | This family consists of bacterial and archaeal proteins. MA1715 from the archaeon Methanosarcina acetivorans is required for optimal growth with sulfide as the sole sulfur source and has been shown to support both cysteine and homocysteine biosynthesis [ ]. The protein is thought to capture environmental sulfide, catal... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF006421"
] | [
"UCP006421"
] | [
1231
] | 1 | [] | [] | [] | 0 | [
"2o34"
] | 1 | [
"PUB00086973",
"PUB00158972",
"PUB00158993"
] | [
"27137504",
"30932481",
"28165724"
] | [
"Efficient Sulfide Assimilation in Methanosarcina acetivorans Is Mediated by the MA1715 Protein.",
"Identification of an Enzyme Catalyzing the Conversion of Sulfoacetaldehyde to 2-Mercaptoethanesulfonic Acid in Methanogens.",
"Persulfide Formation Mediates Cysteine and Homocysteine Biosynthesis in Methanosarcin... | [
2016,
2019,
2017
] | 3 | [] | [
"IPR037456"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
250,
951,
30
] | 3 | [] | [] | 0 | true | Family | Uncharacterised protein family UPF0280 | Uncharacterised protein family UPF0280 | UPF0280 | 7 |
IPR007184 | 7,184 | Mannoside phosphorylase | Mannoside_phosphorylase | Family | 9,325 | false | false | This family of glycosyl hydrolases include 4-O-beta-D-mannosyl-D-glucose phosphorylase (RaMP1) and beta-1,4-mannooligosaccharide phosphorylase (RaMP2). The first one converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose, while the second one catalyses the phosphorolysis... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04041",
"PIRSF016202",
"PTHR34106"
] | [
"Glyco_hydro_130",
"PH1107",
""
] | [
9268,
5824,
9231
] | 3 | [] | [] | [] | 0 | [
"1vkd",
"3qc2",
"3r67",
"3taw",
"3was",
"3wat",
"3wau",
"4kmi",
"4onz",
"4udg",
"4udi",
"4udj",
"4udk",
"5a7v",
"5ay9",
"5ayc",
"5ayd",
"5aye",
"5b0p",
"5b0q",
"5b0r",
"5b0s",
"7fip",
"7fiq",
"7fir",
"7fis",
"9eqq",
"9erg",
"9erh",
"9fj8",
"9fjz",
"9gph"... | 33 | [
"PUB00068791"
] | [
"23093406"
] | [
"Metabolic mechanism of mannan in a ruminal bacterium, Ruminococcus albus, involving two mannoside phosphorylases and cellobiose 2-epimerase: discovery of a new carbohydrate phosphorylase, β-1,4-mannooligosaccharide phosphorylase."
] | [
2012
] | 1 | [] | [
"IPR028583"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
193,
8437,
344,
1,
350
] | 5 | [] | [] | 0 | true | Family | Mannoside phosphorylase | Mannoside phosphorylase | Mannoside_phosphorylase | 7 |
IPR007185 | 7,185 | DNA polymerase alpha/delta/epsilon, subunit B | DNA_pol_a/d/e_bsu | Domain | 14,942 | false | false | DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA p... | [
"GO:0003677",
"GO:0006260"
] | [
"DNA binding",
"DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04042"
] | [
"DNA_pol_E_B"
] | [
14942
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110314",
"R-BTA-174411",
"R-BTA-174414",
"R-BTA-174417",
"R-BTA-174437",
"R-BTA-5358565",
"R-BTA-5358606",
"R-BTA-5651801",
"R-BTA-5656169",
"R-BTA-5685942",
"R-BTA-5696397",
"R-BTA-5696400",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-69091",
"R-BTA-69166",
"R-BTA-69183",
"R-C... | [
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-174411",
"REACTOME:R-BTA-174414",
"REACTOME:R-BTA-174417",
"REACTOME:R-BTA-174437",
"REACTOME:R-BTA-5358565",
"REACTOME:R-BTA-5358606",
"REACTOME:R-BTA-5651801",
"REACTOME:R-BTA-5656169",
"REACTOME:R-BTA-5685942",
"REACTOME:R-BTA-5696397",
"REACTOME:R-B... | 149 | [
"3e0j",
"3flo",
"4y97",
"5exr",
"5vbn",
"6hmf",
"6hms",
"6hv8",
"6hv9",
"6knb",
"6knc",
"6p1h",
"6s1m",
"6s1n",
"6s1o",
"6t8h",
"6tny",
"6tnz",
"6v8p",
"6v93",
"6wjv",
"7kc0",
"7lxd",
"7opl",
"7pfo",
"7plo",
"7pmk",
"7pmn",
"7qhs",
"7s0t",
"7u5c",
"7uy8"... | 75 | [
"PUB00010584"
] | [
"11872158"
] | [
"The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA."
] | [
2002
] | 1 | [] | [
"IPR041863"
] | 0 | 1 | 0 | [
"Archaea",
"Clandestinovirus",
"Eukaryota",
"metagenomes"
] | [
742,
1,
14172,
27
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
19,
3,
7,
4,
21,
11,
3,
12,
15,
3,
3,
18
] | 12 | true | Domain | DNA polymerase alpha/delta/epsilon, subunit B | DNA polymerase alpha/delta/epsilon, subunit B | DNA_pol_a/d/e_bsu | 5 |
IPR007188 | 7,188 | Actin-related protein 2/3 complex subunit 2 | ARPC2 | Family | 5,617 | false | false | Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [ ]. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family prot... | [
"GO:0034314",
"GO:0005885",
"GO:0015629"
] | [
"Arp2/3 complex-mediated actin nucleation",
"Arp2/3 protein complex",
"actin cytoskeleton"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04045",
"PTHR12058"
] | [
"P34-Arc",
""
] | [
5487,
5532
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2029482",
"R-BTA-3928662",
"R-BTA-5663213",
"R-BTA-8856828",
"R-CEL-2029482",
"R-CEL-3928662",
"R-CEL-5663213",
"R-CEL-8856828",
"R-DDI-2029482",
"R-DDI-5663213",
"R-DME-2029482",
"R-DME-3928662",
"R-DME-5663213",
"R-DME-8856828",
"R-HSA-2029482",
"R-HSA-3928662",
"R-HSA-56632... | [
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-5663213",
"REACTOME:R-BTA-8856828",
"REACTOME:R-CEL-2029482",
"REACTOME:R-CEL-3928662",
"REACTOME:R-CEL-5663213",
"REACTOME:R-CEL-8856828",
"REACTOME:R-DDI-2029482",
"REACTOME:R-DDI-5663213",
"REACTOME:R-DME-2029482",
"REACTOM... | 32 | [
"1k8k",
"1tyq",
"1u2v",
"2p9i",
"2p9k",
"2p9l",
"2p9n",
"2p9p",
"2p9s",
"2p9u",
"3dwl",
"3dxk",
"3dxm",
"3rse",
"3ukr",
"3uku",
"3ule",
"4jd2",
"4xei",
"4xf2",
"6dec",
"6uhc",
"6w17",
"6w18",
"6yw6",
"6yw7",
"7aqk",
"7jpn",
"7t5q",
"7tpt",
"8e9b",
"8p94"... | 40 | [
"PUB00020552",
"PUB00022758",
"PUB00035127",
"PUB00035128"
] | [
"9889097",
"15505213",
"9600938",
"11752435"
] | [
"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.",
"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.",
"The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formati... | [
1998,
2004,
1998,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5617
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
1,
2,
6,
4,
1,
6,
7,
1,
1,
18
] | 12 | true | Family | Actin-related protein 2/3 complex subunit 2 | Actin-related protein 2/3 complex subunit 2 | ARPC2 | 4 |
IPR007191 | 7,191 | Exocyst complex component Sec8, N-terminal | Sec8_exocyst_N | Domain | 4,496 | false | false | Sec8 is a component of the exocyst complex, composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane. The exocyst promotes the assembly of SNARE complex for membrane fusion and it is also involved in many cellular processes s... | [
"GO:0006887",
"GO:0000145"
] | [
"exocytosis",
"exocyst"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04048"
] | [
"Sec8_N"
] | [
4496
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-264876",
"R-CEL-5620916",
"R-DDI-264876",
"R-DME-264876",
"R-DME-5620916",
"R-HSA-1445148",
"R-HSA-264876",
"R-HSA-5620916",
"R-MMU-264876",
"R-MMU-5620916",
"R-RNO-264876",
"R-RNO-5620916"
] | [
"REACTOME:R-CEL-264876",
"REACTOME:R-CEL-5620916",
"REACTOME:R-DDI-264876",
"REACTOME:R-DME-264876",
"REACTOME:R-DME-5620916",
"REACTOME:R-HSA-1445148",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-5620916",
"REACTOME:R-MMU-264876",
"REACTOME:R-MMU-5620916",
"REACTOME:R-RNO-264876",
"REACTOME:R-RN... | 12 | [
"5yfp",
"6vkl"
] | 2 | [
"PUB00100047",
"PUB00100048"
] | [
"34061181",
"29335562"
] | [
"Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.",
"Cryo-EM structure of the exocyst complex."
] | [
2021,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4496
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
2,
3,
7,
1,
3,
4,
1,
1,
13
] | 12 | true | Domain | Exocyst complex component Sec8, N-terminal | Exocyst complex component Sec8, N-terminal | Sec8_exocyst_N | 8 |
IPR007192 | 7,192 | Cdc23 | APC8 | Domain | 5,527 | false | false | The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8). This entry is for CDC23. | [
"GO:0005680"
] | [
"anaphase-promoting complex"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04049"
] | [
"ANAPC8"
] | [
5527
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-141430",
"R-BTA-174048",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-176407",
"R-BTA-176408",
"R-BTA-176409",
"R-BTA-176412",
"R-BTA-179409",
"R-BTA-2467813",
"R-BTA-2559582",
"R-BTA-68867",
"R-BTA-69017",
"R-BTA-983168",
"R-CEL-983168",
"R-DDI-141... | [
"REACTOME:R-BTA-141430",
"REACTOME:R-BTA-174048",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-176407",
"REACTOME:R-BTA-176408",
"REACTOME:R-BTA-176409",
"REACTOME:R-BTA-176412",
"REACTOME:R-BTA-179409",
"REACTOME:R-BTA-246... | 68 | [
"3zn3",
"4ui9",
"5a31",
"5ftp",
"5g04",
"5g05",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"6q6g",
"6q6h",
"6tlj",
"6tm5",
"6tnt",
"8a3t",
"8a5y",
"8a61",
"8pkp",
"8tar",
"8tau",
"9gaw",
"9n9r",
"9n9s"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
6,
5520,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
4,
1,
4,
1,
5,
7,
1,
1,
6
] | 12 | true | Domain | Cdc23 | Cdc23 | APC8 | 6 |
IPR007193 | 7,193 | Up-frameshift suppressor 2, C-terminal | Upf2/Nmd2_C | Domain | 4,767 | false | false | This entry represents the C-terminal domain found in Up-frameshift suppressor 2 (also known as Nonsense-mediated mRNA decay protein 2). Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04050"
] | [
"Upf2"
] | [
4767
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9010553",
"R-HSA-975957",
"R-MMU-975957",
"R-SCE-975957",
"R-SPO-975957"
] | [
"REACTOME:R-HSA-9010553",
"REACTOME:R-HSA-975957",
"REACTOME:R-MMU-975957",
"REACTOME:R-SCE-975957",
"REACTOME:R-SPO-975957"
] | 5 | [
"2wjv"
] | 1 | [
"PUB00010602"
] | [
"11073994"
] | [
"Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4767
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
2,
3,
1,
3,
2,
1,
6,
5,
1,
1,
38
] | 12 | true | Domain | Up-frameshift suppressor 2, C-terminal | Up-frameshift suppressor 2, C-terminal | Upf2/Nmd2_C | 4 |
IPR007194 | 7,194 | Transport protein particle (TRAPP) component | TRAPP_component | Family | 14,739 | false | false | TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterised TRAPP proteins and has a d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04051"
] | [
"TRAPP"
] | [
14739
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-204005",
"R-BTA-8876198",
"R-CEL-204005",
"R-CEL-8876198",
"R-DDI-204005",
"R-DDI-8876198",
"R-DRE-204005",
"R-GGA-204005",
"R-HSA-204005",
"R-HSA-8876198",
"R-MMU-204005",
"R-MMU-8876198",
"R-PFA-204005",
"R-PFA-8876198",
"R-RNO-204005",
"R-RNO-8876198",
"R-SCE-204005",
"R-... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-8876198",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DRE-204005",
"REACTOME:R-GGA-204005",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU... | 20 | [
"1sz7",
"1wc8",
"1wc9",
"2bjn",
"2c0j",
"2cfh",
"2j3r",
"2j3t",
"2j3w",
"2pwn",
"3cue",
"3kxc",
"6aq3",
"7b6d",
"7b6r",
"7b6x",
"7b70",
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7kmt",
"7u05",
"7u06",
"7yh2",
"7yh3"
] | 29 | [
"PUB00020479",
"PUB00020480"
] | [
"9564032",
"15608655"
] | [
"TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.",
"Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP."
] | [
1998,
2005
] | 2 | [] | [
"IPR016696",
"IPR016721",
"IPR037992"
] | 0 | 3 | 0 | [
"Archaea",
"Eukaryota"
] | [
3,
14736
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
3,
4,
3,
15,
11,
4,
13,
24,
3,
3,
36
] | 12 | true | Family | Transport protein particle (TRAPP) component | Transport protein particle (TRAPP) component | TRAPP_component | 2 |
IPR007195 | 7,195 | TolB, N-terminal | TolB_N | Domain | 9,955 | false | false | TolB is a periplasmic protein from Escherichia coli that is part of the Tol-dependent translocation system involving group A and E colicins that is used to penetrate and kill cells [ , , ]. TolB has two domains, an α-helical N-terminal domain that shares structural similarity with the C-terminal domain of transfer RNA ... | [
"GO:0015031",
"GO:0042597"
] | [
"protein transport",
"periplasmic space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04052"
] | [
"TolB_N"
] | [
9955
] | 1 | [] | [] | [] | 0 | [
"1c5k",
"1crz",
"2hqs",
"2ivz",
"2w8b",
"3iax",
"4jml",
"4pwz",
"4r40",
"6pnv",
"7mx5",
"7nst",
"7nsu"
] | 13 | [
"PUB00014149",
"PUB00014150",
"PUB00052731"
] | [
"10545334",
"10673426",
"19696740"
] | [
"Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.",
"The structure of TolB, an essential component of the tol-dependent translocation system, and its protein-protein interaction with the translocation domain of colicin E9.",
"Allosteric beta-propeller signalling in ... | [
1999,
2000,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote AD1000_06_A03"
] | [
9759,
27,
168,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | TolB, N-terminal | TolB, N-terminal | TolB_N | 9 |
IPR007196 | 7,196 | CCR4-Not complex component, Not1, C-terminal | CCR4-Not_Not1_C | Domain | 7,531 | false | false | The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the fiv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04054"
] | [
"Not1"
] | [
7531
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-6804115",
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115",
"R-XTR-429947",
"R-XTR-6804115"
] | [
"REACTOME:R-DRE-6804115",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115",
"REACTOME:R-XTR-429947",
"REACTOME:R-XTR-6804115"
] | 8 | [
"4by6",
"4c0d",
"4c0e",
"4cqo",
"5ajd",
"5fu6",
"5fu7"
] | 7 | [
"PUB00010586",
"PUB00044101",
"PUB00044102",
"PUB00044103"
] | [
"11696541",
"10637334",
"12957374",
"18430587"
] | [
"Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.",
"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.",
"Global control of gene expression in yeast by the Ccr4-Not complex.",
"Biophysic... | [
2002,
2000,
2003,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7531
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
1,
8,
6,
5,
1,
10,
6,
1,
1,
69
] | 12 | true | Domain | CCR4-Not complex component, Not1, C-terminal | CCR4-Not complex component, Not1, C-terminal | CCR4-Not_Not1_C | 2 |
IPR007197 | 7,197 | Radical SAM | rSAM | Domain | 455,997 | false | false | The Radical SAM domain is organised in a fold related to the β-barrel or TIM barrel, in which β-strands are arranged in a barrel-like array, with peripheral helices intervening between β-strands. The [4Fe-4S] clusters and substrates are bound within the barrels, as is typical of TIM barrel enzymes [ , ]. Radical SAM pr... | [
"GO:0003824",
"GO:0051536"
] | [
"catalytic activity",
"iron-sulfur cluster binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE",
"SFLD"
] | [
"PF04055",
"PS51918",
"SFLDS00029"
] | [
"Radical_SAM",
"RADICAL_SAM",
"Radical_SAM"
] | [
425242,
406031,
445608
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-947581",
"R-BTA-9857492",
"R-DDI-947581",
"R-DME-947581",
"R-DME-9857492",
"R-DRE-9857492",
"R-HSA-3214847",
"R-HSA-6782315",
"R-HSA-6782861",
"R-HSA-909733",
"R-HSA-947581",
"R-HSA-9857492",
"R-MMU-947581",
"R-MMU-9857492",
"R-RNO-9857492"
] | [
"REACTOME:R-BTA-947581",
"REACTOME:R-BTA-9857492",
"REACTOME:R-DDI-947581",
"REACTOME:R-DME-947581",
"REACTOME:R-DME-9857492",
"REACTOME:R-DRE-9857492",
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6782861",
"REACTOME:R-HSA-909733",
"REACTOME:R-HSA-947581",
"REACTOME:R-H... | 15 | [
"1olt",
"1r30",
"1tv7",
"1tv8",
"2a5h",
"2fb2",
"2fb3",
"2qgq",
"2yx0",
"2z2u",
"3c8f",
"3can",
"3cb8",
"3ciw",
"3cix",
"3iix",
"3iiz",
"3rf9",
"3rfa",
"3t7v",
"4fhc",
"4fhd",
"4fhe",
"4fhf",
"4fhg",
"4jc0",
"4jxc",
"4jy8",
"4jy9",
"4jyd",
"4jye",
"4jyf"... | 174 | [
"PUB00010539",
"PUB00015124",
"PUB00065909",
"PUB00097555",
"PUB00097556",
"PUB00097557"
] | [
"11222759",
"15317939",
"22761404",
"18307109",
"22579873",
"28893989"
] | [
"Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.",
"Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybd... | [
2001,
2004,
2012,
2008,
2012,
2017
] | 6 | [] | [
"IPR006638"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
18642,
389799,
36466,
1137,
9953
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
49,
8,
16,
5,
20,
34,
16,
8,
38,
34,
4,
4,
93
] | 13 | true | Domain | Radical SAM | Radical SAM | rSAM | 8 |
IPR007199 | 7,199 | Replication factor-A protein 1, N-terminal | Rep_factor-A_N | Domain | 6,452 | false | false | Replication factor-a protein 1 (RPA1) forms a multiprotein complex with RPA2 and RPA3 that binds single-stranded DNA and functions in the recognition of DNA damage for nucleotide excision repair. The complex binds to single-stranded DNA sequences participating in DNA replication in addition to those mediating transcrip... | [
"GO:0003677",
"GO:0006260",
"GO:0005634"
] | [
"DNA binding",
"DNA replication",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"CDD"
] | [
"PF04057",
"cd04477"
] | [
"Rep-A_N",
"RPA1N"
] | [
6415,
4508
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-110312",
"R-DME-110314",
"R-DME-110320",
"R-DME-176187",
"R-DME-3108214",
"R-DME-3371453",
"R-DME-5358565",
"R-DME-5651801",
"R-DME-5655862",
"R-DME-5656121",
"R-DME-5656169",
"R-DME-5693607",
"R-DME-5696395",
"R-DME-5696397",
"R-DME-5696400",
"R-DME-6782135",
"R-DME-6782210",... | [
"REACTOME:R-DME-110312",
"REACTOME:R-DME-110314",
"REACTOME:R-DME-110320",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3371453",
"REACTOME:R-DME-5358565",
"REACTOME:R-DME-5651801",
"REACTOME:R-DME-5655862",
"REACTOME:R-DME-5656121",
"REACTOME:R-DME-5656169",
"REACTOME:R-... | 160 | [
"1ewi",
"2b29",
"2b3g",
"4ijh",
"4ijl",
"4ipc",
"4ipd",
"4ipg",
"4iph",
"4luo",
"4luv",
"4luz",
"4lw1",
"4lwc",
"4nb3",
"4o0a",
"4r4c",
"4r4i",
"4r4o",
"4r4q",
"4r4t",
"5e7n",
"5eay",
"5m1x",
"5n85",
"5n8a",
"5omb",
"5omc",
"7xut",
"7xuv",
"7xuw",
"7xv0"... | 41 | [
"PUB00028097"
] | [
"7753855"
] | [
"Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6452
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
20,
1,
1,
3,
3,
1,
5,
4,
1,
1,
14
] | 11 | true | Domain | Replication factor-A protein 1, N-terminal | Replication factor-A protein 1, N-terminal | Rep_factor-A_N | 1 |
IPR007201 | 7,201 | Mei2-like, C-terminal RNA recognition motif | Mei2-like_Rrm_C | Domain | 9,258 | false | false | This RNA recognition motif 2 is found in meiosis protein mei2 and mei2-like proteins [ ]. It is found C-terminal to the RNA-binding region RNP-1 ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04059"
] | [
"RRM_2"
] | [
9258
] | 1 | [] | [] | [] | 0 | [
"6yyl",
"6yym",
"7dus",
"7eio",
"7eiu"
] | 5 | [
"PUB00020274"
] | [
"14986133"
] | [
"A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context."
] | [
2004
] | 1 | [] | [
"IPR034454",
"IPR034458"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
9258
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
46,
1,
13,
1,
108
] | 5 | true | Domain | Mei2-like, C-terminal RNA recognition motif | Mei2-like, C-terminal RNA recognition motif | Mei2-like_Rrm_C | 3 |
IPR007202 | 7,202 | 4Fe-4S domain | 4Fe-4S_dom | Domain | 13,844 | false | false | The cobalt- and iron-containing corrinoid iron-sulfur protein (CoFeSP) is functional in the acetyl-CoA pathway of autotrophic carbon fixation in various bacteria and acrchaea, where it is essential for the biosynthesis of acetyl- CoA. CoFeSP acts in two methylation reactions: the transfer of a methyl group from methylt... | [
"GO:0051536"
] | [
"iron-sulfur cluster binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF04060",
"PS51656"
] | [
"FeS",
"4FE4S"
] | [
13210,
13816
] | 2 | [] | [] | [] | 0 | [
"2h9a",
"2ycl",
"4c1n",
"4djd",
"4dje",
"4djf",
"7zc6",
"8ahx",
"8rb8",
"8rb9",
"8rbm",
"8rbq",
"9eri",
"9erj",
"9erk",
"9erl",
"9fzy",
"9fzz",
"9g00"
] | 19 | [
"PUB00041329",
"PUB00056300",
"PUB00063922"
] | [
"16983091",
"21640123",
"22419154"
] | [
"Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis.",
"Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway.",
"Visualizing molecular juggling within a B12-dependent... | [
2006,
2011,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
901,
12605,
8,
330
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | 4Fe-4S domain | 4Fe-4S domain | 4Fe-4S_dom | 4 |
IPR007203 | 7,203 | ORMDL family | ORMDL | Family | 6,158 | false | false | ORMDL family members include ORMDL1/2/3 from humans and their homologues, such as protein Orm1 and Orm2 from budding yeasts. ORMDLs may be involved in protein folding in the endoplasmic reticulum [ ]. In budding yeast, Orm1 and Orm2 proteins mediate sphingolipid homeostasis [ ]. | [
"GO:0005789",
"GO:0016020"
] | [
"endoplasmic reticulum membrane",
"membrane"
] | [
"cellular_component",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04061",
"PIRSF018147",
"PTHR12665"
] | [
"ORMDL",
"ORMDL",
""
] | [
6155,
4403,
6066
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1660661",
"R-BTA-6798695",
"R-DME-1660661",
"R-DME-6798695",
"R-DRE-1660661",
"R-DRE-6798695",
"R-HSA-1660661",
"R-HSA-6798695",
"R-MMU-1660661",
"R-MMU-6798695",
"R-RNO-1660661",
"R-RNO-6798695",
"R-SCE-6798695",
"R-SPO-6798695"
] | [
"REACTOME:R-BTA-1660661",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DME-1660661",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-1660661",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-1660661",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-1660661",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-1660661",
"REACTOM... | 14 | [
"6m4n",
"6m4o",
"7cqi",
"7cqk",
"7k0m",
"7k0n",
"7k0o",
"7k0p",
"7k0q",
"7yiu",
"7yiy",
"7yj1",
"7yj2",
"7yjk",
"7yjm",
"7yjn",
"7yjo",
"8c80",
"8c81",
"8c82",
"8iaj",
"8iak",
"8iam",
"8qof",
"8qog"
] | 25 | [
"PUB00019967",
"PUB00071216"
] | [
"12093374",
"20182505"
] | [
"ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins.",
"Orm family proteins mediate sphingolipid homeostasis."
] | [
2002,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6158
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
7,
5,
2,
10,
5,
1,
8,
9,
2,
1,
21
] | 11 | true | Family | ORMDL family | ORMDL family | ORMDL | 8 |
IPR007204 | 7,204 | Actin-related protein 2/3 complex subunit 3 | ARPC3 | Family | 4,499 | false | false | Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [ ]. The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, prov... | [
"GO:0034314",
"GO:0005856",
"GO:0005885"
] | [
"Arp2/3 complex-mediated actin nucleation",
"cytoskeleton",
"Arp2/3 protein complex"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04062",
"PIRSF016315",
"PTHR12391"
] | [
"P21-Arc",
"ARP2/3_P21-Arc",
""
] | [
4495,
3848,
4383
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2029482",
"R-BTA-3928662",
"R-BTA-5663213",
"R-BTA-8856828",
"R-CEL-2029482",
"R-CEL-3928662",
"R-CEL-5663213",
"R-CEL-8856828",
"R-DDI-2029482",
"R-DDI-5663213",
"R-HSA-2029482",
"R-HSA-3928662",
"R-HSA-5663213",
"R-HSA-8856828",
"R-HSA-9664422",
"R-MMU-2029482",
"R-MMU-39286... | [
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-5663213",
"REACTOME:R-BTA-8856828",
"REACTOME:R-CEL-2029482",
"REACTOME:R-CEL-3928662",
"REACTOME:R-CEL-5663213",
"REACTOME:R-CEL-8856828",
"REACTOME:R-DDI-2029482",
"REACTOME:R-DDI-5663213",
"REACTOME:R-HSA-2029482",
"REACTOM... | 24 | [
"1k8k",
"1tyq",
"1u2v",
"2p9i",
"2p9k",
"2p9l",
"2p9n",
"2p9p",
"2p9s",
"2p9u",
"3dwl",
"3dxk",
"3dxm",
"3rse",
"3ukr",
"3uku",
"3ule",
"4jd2",
"4xei",
"4xf2",
"6dec",
"6uhc",
"6w17",
"6w18",
"6yw6",
"6yw7",
"7aqk",
"7jpn",
"7t5q",
"7tpt",
"8e9b",
"8p94"... | 40 | [
"PUB00008558",
"PUB00020552",
"PUB00022758",
"PUB00035127",
"PUB00035128",
"PUB00101759"
] | [
"9230079",
"9889097",
"15505213",
"9600938",
"11752435",
"29925947"
] | [
"The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.",
"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.",
"Crystal structures of actin-related ... | [
1997,
1998,
2004,
1998,
2001,
2018
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4499
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
4,
6,
5,
1,
5,
5,
1,
1,
18
] | 12 | true | Family | Actin-related protein 2/3 complex subunit 3 | Actin-related protein 2/3 complex subunit 3 | ARPC3 | 3 |
IPR007205 | 7,205 | Protein HGH1 N-terminal | Protein_HGH1_N | Domain | 3,867 | false | false | This entry represents a domain within Protein HGH1, of unknown function. It is found N-terminal to another domain of unknown function ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04063"
] | [
"DUF383"
] | [
3867
] | 1 | [] | [] | [] | 0 | [
"6hb1",
"6hb2",
"6hb3"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3867
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
2,
1,
1,
5,
1,
1,
1,
4
] | 12 | true | Domain | Protein HGH1 N-terminal | Protein HGH1 N-terminal | Protein_HGH1_N | 3 |
IPR007206 | 7,206 | Protein HGH1 C-terminal | Protein_HGH1_C | Domain | 3,792 | false | false | This entry represents a domain within Protein HGH1, of unknown function. It is found C-terminal to another domain of unknown function ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04064"
] | [
"DUF384"
] | [
3792
] | 1 | [] | [] | [] | 0 | [
"6hb1",
"6hb2",
"6hb3"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3792
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
4,
1,
1,
4,
1,
1,
1,
4
] | 12 | true | Domain | Protein HGH1 C-terminal | Protein HGH1 C-terminal | Protein_HGH1_C | 7 |
IPR007207 | 7,207 | CCR4-Not complex component, Not N-terminal domain | Not_N | Domain | 6,523 | false | false | The Ccr4-Not complex (Not1, Not2, Not3, Not4 and Not5) is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [ ]. This domain is the N-terminal region of the Not proteins. | [
"GO:0006355",
"GO:0005634"
] | [
"regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04065"
] | [
"Not3"
] | [
6523
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115"
] | [
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115"
] | 5 | [
"6tb3",
"8bhf",
"8k82",
"9c3h",
"9c3i"
] | 5 | [
"PUB00010587"
] | [
"7926748"
] | [
"NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paenibacillus apii",
"bird metagenome"
] | [
6521,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
7,
1,
8,
5,
1,
4,
1,
2,
1,
27
] | 12 | true | Domain | CCR4-Not complex component, Not N-terminal domain | CCR4-Not complex component, Not N-terminal domain | Not_N | 9 |
IPR007208 | 7,208 | Na(+)/H(+) antiporter subunit F-like | MrpF/PhaF-like | Family | 12,846 | false | false | Members of this family are predicted to be integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti (Sinorhizobium meliloti) [ ]. MrpF is a part of a Na + /H + an... | [
"GO:0015075",
"GO:0034220",
"GO:0016020"
] | [
"monoatomic ion transmembrane transporter activity",
"monoatomic ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04066",
"PIRSF028784",
"PTHR34702"
] | [
"MrpF_PhaF",
"MrpF",
""
] | [
12825,
5595,
11883
] | 3 | [] | [] | [] | 0 | [
"6cfw",
"6u8y",
"6z16",
"7d3u",
"7qru"
] | 5 | [
"PUB00009818",
"PUB00009819",
"PUB00010603"
] | [
"10198001",
"11356194",
"9680201"
] | [
"mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.",
"Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters.",
"The pha gene cluster of Rhizobiu... | [
1999,
2001,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
807,
11878,
7,
154
] | 4 | [] | [] | 0 | true | Family | Na(+)/H(+) antiporter subunit F-like | Na(+)/H(+) antiporter subunit F-like | MrpF/PhaF-like | 7 |
IPR007209 | 7,209 | RNase L inhibitor RLI-like, possible metal-binding domain | RNaseL-inhib-like_metal-bd_dom | Domain | 10,820 | false | false | This is part of a possible metal-binding domain in endoribonuclease RNase L inhibitor. It is found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, . Also often found adjacent to in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-prol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04068"
] | [
"Fer4_RLI"
] | [
10820
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.157",
"PWY-8341",
"R-HSA-6790901",
"R-HSA-8983711",
"R-HSA-909733",
"R-MMU-8983711",
"R-MMU-909733"
] | [
"EC:2.5.1.157",
"METACYC:PWY-8341",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-8983711",
"REACTOME:R-HSA-909733",
"REACTOME:R-MMU-8983711",
"REACTOME:R-MMU-909733"
] | 7 | [
"3bk7",
"3j15",
"3j16",
"3jag",
"3jah",
"3jai",
"4crm",
"5ap8",
"5ll6",
"5lw7",
"5lzv",
"6hcf",
"6hcm",
"6tmf",
"6yal",
"6yam",
"6zce",
"6zme",
"6zu9",
"6zvj",
"7a09",
"7a1g",
"7o80",
"8cah",
"8cas",
"8p03",
"8p09",
"8scb"
] | 28 | [
"PUB00009821",
"PUB00009822",
"PUB00045430",
"PUB00096731"
] | [
"9524254",
"7539425",
"15660135",
"15277527"
] | [
"cDNA cloning and expression analysis of the murine ribonuclease L inhibitor.",
"Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway.",
"Functional link between ribosome formation and biogenesis of iron-sulfur proteins.",
"The essential ATP-binding cas... | [
1998,
1995,
2005,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"unclassified sequences"
] | [
1539,
3,
9221,
6,
51
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
3,
2,
4,
12,
2,
13,
5,
2,
2,
14
] | 12 | true | Domain | RNase L inhibitor RLI-like, possible metal-binding domain | RNase L inhibitor RLI-like, possible metal-binding domain | RNaseL-inhib-like_metal-bd_dom | 1 |
IPR007210 | 7,210 | ABC-type glycine betaine transport system, substrate-binding domain | ABC_Gly_betaine_transp_sub-bd | Domain | 46,797 | false | false | This domain is a part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. It is often found in integral membrane proteins or proteins predicted to be attached to the membrane b... | [
"GO:0022857",
"GO:0055085",
"GO:0043190"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"ATP-binding cassette (ABC) transporter complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04069"
] | [
"OpuAC"
] | [
46797
] | 1 | [
"GP"
] | [
"GenProp1126"
] | [
"GP:GenProp1126"
] | 1 | [
"1r9l",
"1r9q",
"1sw1",
"1sw2",
"1sw4",
"1sw5",
"2b4l",
"2b4m",
"2reg",
"2rej",
"2rf1",
"2rin",
"3chg",
"3hcq",
"3l6g",
"3l6h",
"3mam",
"3o66",
"3ppn",
"3ppo",
"3ppp",
"3ppq",
"3ppr",
"3r6u",
"3tmg",
"4nd9",
"4ne4",
"4wep",
"4xz6",
"4z7e",
"5nxx",
"5nxy"... | 64 | [
"PUB00009831",
"PUB00009832"
] | [
"7622480",
"10216873"
] | [
"OpuA, an osmotically regulated binding protein-dependent transport system for the osmoprotectant glycine betaine in Bacillus subtilis.",
"Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis."
] | [
1995,
1999
] | 2 | [] | [
"IPR041894",
"IPR058089"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Siphoviridae sp. ctuHu10",
"unclassified sequences"
] | [
45881,
228,
319,
1,
368
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
3
] | 2 | true | Domain | ABC-type glycine betaine transport system, substrate-binding domain | ABC-type glycine betaine transport system, substrate-binding domain | ABC_Gly_betaine_transp_sub-bd | 1 |
IPR007211 | 7,211 | Protein of unknown function DUF378 | DUF378 | Family | 4,080 | false | false | These are predicted membrane proteins of unknown function. The majority of the proteins have two predicted transmembrane regions. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04070",
"PTHR37304"
] | [
"DUF378",
""
] | [
4078,
3889
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Blyttiomyces helicus",
"Viruses",
"unclassified sequences"
] | [
114,
3891,
1,
19,
55
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function DUF378 | Protein of unknown function DUF378 | DUF378 | 5 |
IPR007212 | 7,212 | Cysteine-rich small domain | Zf-like | Domain | 939 | false | false | This is a probable metal-binding domain. It is found in a probable precorrin-3B C17-methyltransferase from Methanobacterium thermoautotrophicum, that catalyses the methylation of C-17 in precorrin-3B to form precorrin-4. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04071"
] | [
"zf-like"
] | [
939
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
290,
631,
18
] | 3 | [] | [] | 0 | true | Domain | Cysteine-rich small domain | Cysteine-rich small domain | Zf-like | 2 |
IPR007214 | 7,214 | YbaK/aminoacyl-tRNA synthetase-associated domain | YbaK/aa-tRNA-synth-assoc-dom | Domain | 60,741 | false | false | Bacterial prolyl-tRNA synthetases and some smaller paralogues, YbaK and ProX, can hydrolyse misacylated Cys-tRNA(Pro) or Ala-tRNA(Pro) [ ]. The small bacterial protein Ybak preferentially hydrolyses Cys-tRNA(Pro) and Cys-tRNA(Cys) [ , ]. ProX functions in trans to edit the amino acid moiety from incorrectly charged Ala... | [
"GO:0002161"
] | [
"aminoacyl-tRNA deacylase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04073"
] | [
"tRNA_edit"
] | [
60741
] | 1 | [
"EC"
] | [
"6.1.1.15"
] | [
"EC:6.1.1.15"
] | 1 | [
"1dbu",
"1dbx",
"1vjf",
"1vki",
"1wdv",
"2cx5",
"2dxa",
"2j3l",
"2j3m",
"2z0k",
"2z0x",
"3op6",
"3ri0",
"3rij",
"5ucm",
"5vxb",
"5znj",
"5znk",
"8huz",
"8w8j",
"8w8l",
"8w9i",
"9bu5",
"9qzk"
] | 24 | [
"PUB00063636",
"PUB00063637",
"PUB00063639",
"PUB00063640"
] | [
"15886196",
"23185990",
"14663147",
"10642548"
] | [
"The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase.",
"Aminoacyl-tRNA Substrate and Enzyme Backbone Atoms Contribute to Translational Quality Control by YbaK.",
"Trans-editing of mischarged tRNAs.",
"One polypeptide with two aminoacyl-tRNA synthetase activities."
] | [
2005,
2012,
2003,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
365,
55718,
3753,
5,
900
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
12,
1,
3,
1,
1,
5,
3,
1,
5
] | 9 | true | Domain | YbaK/aminoacyl-tRNA synthetase-associated domain | YbaK/aminoacyl-tRNA synthetase-associated domain | YbaK/aa-tRNA-synth-assoc-dom | 9 |
IPR007215 | 7,215 | Sulphur relay, TusB/DsrH | Sulphur_relay_TusB/DsrH | Family | 4,226 | false | false | The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulphur relay reaction [ ]. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulphide moiety, delivered by the cysteine desulphurase IscS to TusA, then to TusBCD. The activated sulphur group is then transfer... | [
"GO:0002143",
"GO:0005737"
] | [
"tRNA wobble position uridine thiolation",
"cytoplasm"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF04077",
"PTHR37526",
"TIGR03011"
] | [
"DsrH",
"",
"sulf_tusB_dsrH"
] | [
4226,
3555,
3705
] | 3 | [
"GP",
"GP"
] | [
"GenProp0654",
"GenProp1555"
] | [
"GP:GenProp0654",
"GP:GenProp1555"
] | 2 | [
"1rhx",
"1x9a",
"2d1p",
"2hy5",
"2hyb"
] | 5 | [
"PUB00008255",
"PUB00040153",
"PUB00043028",
"PUB00060601"
] | [
"9695921",
"16472754",
"16387657",
"22815818"
] | [
"Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.",
"Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex.",
"Mechanistic insights into sulfur relay by multiple sulfur media... | [
1998,
2006,
2006,
2012
] | 4 | [] | [
"IPR023526"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
59,
4080,
2,
84,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Sulphur relay, TusB/DsrH | Sulphur relay, TusB/DsrH | Sulphur_relay_TusB/DsrH | 8 |
IPR007216 | 7,216 | CCR4-NOT transcription complex subunit 9 | CNOT9 | Family | 6,548 | false | false | This entry includes CCR4-NOT transcription complex subunit 9 (CNOT9 or Rcd1). Mammalian CNOT9 is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression durin... | [
"GO:0006402",
"GO:0030014"
] | [
"mRNA catabolic process",
"CCR4-NOT complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04078",
"PTHR12262"
] | [
"Rcd1",
""
] | [
6527,
6465
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-429947",
"R-BTA-6804115",
"R-DRE-6804115",
"R-HSA-429947",
"R-HSA-5617472",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115",
"R-RNO-6804115",
"R-XTR-429947",
"R-XTR-6804115"
] | [
"REACTOME:R-BTA-429947",
"REACTOME:R-BTA-6804115",
"REACTOME:R-DRE-6804115",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-5617472",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115",
"REACTOME:R-RNO-6804115",
"REACTOME:R-XTR-429947",
"REACTOME:R-... | 12 | [
"2fv2",
"4cru",
"4crv",
"4ct6",
"4ct7",
"4cv5",
"5lsw",
"5ona",
"5onb",
"6hom",
"6hon",
"9fl8",
"9jnj",
"9jnl",
"9jnm"
] | 15 | [
"PUB00010590",
"PUB00010591",
"PUB00020225",
"PUB00075516"
] | [
"9671458",
"9447985",
"12356739",
"18180299"
] | [
"An RNA binding protein negatively controlling differentiation in fission yeast.",
"Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.",
"Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.",
"Components of the ... | [
1998,
1998,
2002,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6548
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
1,
1,
8,
6,
1,
1,
14,
4,
1,
1,
21
] | 12 | true | Family | CCR4-NOT transcription complex subunit 9 | CCR4-NOT transcription complex subunit 9 | CNOT9 | 8 |
IPR007217 | 7,217 | Per1-like | Per1-like | Family | 5,564 | false | false | PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins [ ]. PER1 is part of the CREST superfamily [ ]. Human PERLD1 is a functional homologue of PER1, and is also known as PGAP3. Mutations in PGAP3 cause hyperphosphatasia with mental retardation syndrome [ ]. | [
"GO:0006506"
] | [
"GPI anchor biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04080",
"PTHR13148"
] | [
"Per1",
""
] | [
5558,
5458
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.1.-",
"PWY-1921",
"PWY-5835",
"PWY-6190",
"PWY-6308",
"PWY-6322",
"PWY-6339",
"PWY-6415",
"PWY-6558",
"PWY-6848",
"PWY-7002",
"PWY-7352",
"PWY-7367",
"PWY-7521",
"PWY-7599",
"PWY-7660",
"PWY-7712",
"PWY-7713",
"PWY-7730",
"PWY-7769",
"PWY-7982",
"PWY-8058",
"PWY-8143... | [
"EC:3.1.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5835",
"METACYC:PWY-6190",
"METACYC:PWY-6308",
"METACYC:PWY-6322",
"METACYC:PWY-6339",
"METACYC:PWY-6415",
"METACYC:PWY-6558",
"METACYC:PWY-6848",
"METACYC:PWY-7002",
"METACYC:PWY-7352",
"METACYC:PWY-7367",
"METACYC:PWY-7521",
"METACYC:PWY-7... | 28 | [] | 0 | [
"PUB00045071",
"PUB00085069",
"PUB00089777"
] | [
"17021251",
"21733186",
"28390064"
] | [
"PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins.",
"CREST--a large and diverse superfamily of putative transmembrane hydrolases.",
"PGAP3-related hyperphosphatasia with mental retardation syndrome: Report of 10 new patients and a homozygous founder m... | [
2006,
2011,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavobacterium gawalongense",
"bird metagenome"
] | [
5562,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
2,
1,
5,
2,
1,
4,
5,
1,
1,
42
] | 12 | true | Family | Per1-like | Per1-like | Per1-like | 3 |
IPR007218 | 7,218 | DNA polymerase delta, subunit 4 | DNA_pol_delta_4 | Family | 3,124 | false | false | DNA polymerase delta (Pol delta) is responsible for effective DNA replication, playing a key role in the elongation of both the leading and the lagging strands of DNA and the maturation of Okazaki fragments [ ]. It consists of four subunits: the catalytic and largest subunit p125, p50 that interacts with p125 to form t... | [
"GO:0000731",
"GO:0006260"
] | [
"DNA synthesis involved in DNA repair",
"DNA replication"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04081",
"PTHR14303"
] | [
"DNA_pol_delta_4",
""
] | [
3094,
2977
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-110314",
"R-HSA-174411",
"R-HSA-174414",
"R-HSA-174417",
"R-HSA-174437",
"R-HSA-5358565",
"R-HSA-5358606",
"R-HSA-5651801",
"R-HSA-5656169",
"R-HSA-5685942",
"R-HSA-5696397",
"R-HSA-5696400",
"R-HSA-6782135",
"R-HSA-6782210",
"R-HSA-69091",
"R-HSA-69166",
"R-HSA-69183",
"R-M... | [
"REACTOME:R-HSA-110314",
"REACTOME:R-HSA-174411",
"REACTOME:R-HSA-174414",
"REACTOME:R-HSA-174417",
"REACTOME:R-HSA-174437",
"REACTOME:R-HSA-5358565",
"REACTOME:R-HSA-5358606",
"REACTOME:R-HSA-5651801",
"REACTOME:R-HSA-5656169",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5696397",
"REACTOME:R-H... | 47 | [
"6s1m",
"6s1n",
"6s1o",
"6tny",
"6tnz",
"9ekb"
] | 6 | [
"PUB00092482",
"PUB00092483",
"PUB00094534",
"PUB00094535",
"PUB00094536",
"PUB00094537"
] | [
"16510448",
"24035200",
"20334433",
"19074196",
"24022480",
"24310611"
] | [
"Functional roles of p12, the fourth subunit of human DNA polymerase delta.",
"Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.",
"The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.",
"DNA da... | [
2006,
2013,
2010,
2009,
2013,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses"
] | [
3122,
2
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
1,
3,
4,
1,
8,
5,
1,
10
] | 9 | true | Family | DNA polymerase delta, subunit 4 | DNA polymerase delta, subunit 4 | DNA_pol_delta_4 | 9 |
IPR007219 | 7,219 | Xylanolytic transcriptional activator, regulatory domain | XnlR_reg_dom | Domain | 201,102 | false | false | This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain ( ) [ , ], including Xylanolytic transcriptional activator (XnlR) and related transcriptional factors. It has been suggested that this region plays a ... | [
"GO:0003677",
"GO:0008270",
"GO:0006351"
] | [
"DNA binding",
"zinc ion binding",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"SMART"
] | [
"PF04082",
"SM00906"
] | [
"Fungal_trans",
"Fungal_trans"
] | [
196123,
139878
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096370",
"PUB00096371",
"PUB00100821",
"PUB00100822"
] | [
"16959962",
"19686338",
"21484208",
"18420433"
] | [
"A fungal family of transcriptional regulators: the zinc cluster proteins.",
"Transcriptional regulation of nonfermentable carbon utilization in budding yeast.",
"Regulation of pentose utilisation by AraR, but not XlnR, differs in Aspergillus nidulans and Aspergillus niger.",
"CreA mediates repression of the ... | [
2006,
2010,
2011,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
2,
201100
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
81,
27,
27
] | 3 | true | Domain | Xylanolytic transcriptional activator, regulatory domain | Xylanolytic transcriptional activator, regulatory domain | XnlR_reg_dom | 7 |
IPR007220 | 7,220 | Origin recognition complex, subunit 2 | ORC2 | Family | 4,754 | false | false | The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded by ORC1-6 [ ]. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle [ ]. ORC directs DNA replication throughout the genome and is required for its in... | [
"GO:0006260",
"GO:0000808",
"GO:0005634"
] | [
"DNA replication",
"origin recognition complex",
"nucleus"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR14052"
] | [
""
] | [
4754
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-68616",
"R-CEL-68949",
"R-CEL-68962",
"R-DDI-68616",
"R-DDI-68689",
"R-DDI-68962",
"R-DME-176187",
"R-DME-68616",
"R-DME-68689",
"R-DME-68949",
"R-DME-68962",
"R-HSA-113507",
"R-HSA-176187",
"R-HSA-68616",
"R-HSA-68689",
"R-HSA-68867",
"R-HSA-68949",
"R-HSA-68962",
"R-MMU-... | [
"REACTOME:R-CEL-68616",
"REACTOME:R-CEL-68949",
"REACTOME:R-CEL-68962",
"REACTOME:R-DDI-68616",
"REACTOME:R-DDI-68689",
"REACTOME:R-DDI-68962",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-68616",
"REACTOME:R-DME-68689",
"REACTOME:R-DME-68949",
"REACTOME:R-DME-68962",
"REACTOME:R-HSA-113507",
"R... | 37 | [
"4xgc",
"5c8h",
"5uj8",
"5ujm",
"5v8f",
"5zr1",
"6rqc",
"6wgc",
"6wgg",
"6wgi",
"7cte",
"7ctf",
"7ctg",
"7jgr",
"7jgs",
"7jk2",
"7jk3",
"7jk4",
"7jk5",
"7jk6",
"7jpo",
"7jpp",
"7jpq",
"7jpr",
"7jps",
"7mca",
"7tjf",
"7tjh",
"7tji",
"7tjj",
"7tjk",
"8rwv"... | 44 | [
"PUB00052559",
"PUB00052560",
"PUB00052561",
"PUB00052562",
"PUB00052563",
"PUB00052564",
"PUB00052565",
"PUB00052566",
"PUB00052567",
"PUB00052568",
"PUB00052569",
"PUB00052570",
"PUB00052571",
"PUB00052572",
"PUB00052573",
"PUB00052574",
"PUB00052575",
"PUB00052576",
"PUB000525... | [
"17241905",
"17825065",
"1579162",
"7585959",
"16716188",
"7892251",
"7781615",
"16228006",
"10966477",
"12045100",
"15680967",
"11572976",
"11429609",
"16024805",
"8622770",
"9171055",
"9038340",
"11459976",
"15610739",
"16387651",
"17053779",
"9442876",
"31160578",
"3... | [
"Multiple functions of the origin recognition complex.",
"Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.",
"ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.... | [
2007,
2007,
1992,
1995,
2006,
1995,
1995,
2005,
2000,
2002,
2005,
2001,
2001,
2005,
1996,
1997,
1997,
2001,
2004,
2006,
2006,
1997,
2019,
2020
] | 24 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4754
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
2,
3,
1,
1,
4,
1,
2,
4
] | 12 | true | Family | Origin recognition complex, subunit 2 | Origin recognition complex, subunit 2 | ORC2 | 9 |
IPR007221 | 7,221 | Rod shape-determining protein MreC | MreC | Family | 20,686 | false | false | MreC (murein formation C) is involved in the rod shape determination in Escherichia coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped [ ]. | [
"GO:0008360"
] | [
"regulation of cell shape"
] | [
"biological_process"
] | 1 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF038471",
"PTHR34138",
"TIGR00219"
] | [
"MreC",
"",
"mreC"
] | [
12814,
20678,
14300
] | 3 | [
"GP"
] | [
"GenProp0166"
] | [
"GP:GenProp0166"
] | 1 | [
"2j5u",
"2qf4",
"2qf5",
"5lp5",
"6zlv",
"6zm0",
"7eft",
"9dvb",
"9dvc"
] | 9 | [
"PUB00056833"
] | [
"2687239"
] | [
"New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
20114,
25,
547
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Rod shape-determining protein MreC | Rod shape-determining protein MreC | MreC | 1 |
IPR007222 | 7,222 | Signal recognition particle receptor, alpha subunit, N-terminal | SRPRA_N | Domain | 4,879 | false | false | This entry represents the N-terminal domain of the alpha subunit of the SR receptor (SRPA). This domain is responsible for tethering the SRPA to the ER membrane bound subunit beta (SRPB or SRbeta) [ , ]. The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is invo... | [
"GO:0003924",
"GO:0005047",
"GO:0005525",
"GO:0006886",
"GO:0005785"
] | [
"GTPase activity",
"signal recognition particle binding",
"GTP binding",
"intracellular protein transport",
"signal recognition particle receptor complex"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PFAM"
] | [
"PF04086"
] | [
"SRP-alpha_N"
] | [
4879
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1799339",
"R-HSA-381038"
] | [
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-381038"
] | 2 | [
"2fh5",
"2go5",
"5ck3",
"5l3q",
"6frk",
"7nfx",
"7obq"
] | 7 | [
"PUB00022264",
"PUB00028143",
"PUB00035998",
"PUB00035999",
"PUB00036002",
"PUB00036003",
"PUB00041125",
"PUB00043979",
"PUB00053948",
"PUB00063486",
"PUB00100261",
"PUB00163186"
] | [
"12654246",
"16469117",
"17622352",
"17507650",
"7844142",
"10859309",
"16675701",
"16439358",
"12364595",
"12605305",
"34020957",
"27241309"
] | [
"Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor.",
"Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.",
"X-ray structures of the signal recognition particle receptor reveal targeting... | [
2003,
2006,
2007,
2007,
1995,
2000,
2006,
2006,
2002,
2003,
2021,
2016
] | 12 | [] | [] | 0 | 0 | null | [
"Corynebacterium appendicis CIP 107643",
"Eukaryota"
] | [
1,
4878
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
3,
1,
1,
2,
2,
4,
1,
5,
2,
1,
8
] | 11 | true | Domain | Signal recognition particle receptor, alpha subunit, N-terminal | Signal recognition particle receptor, alpha subunit, N-terminal | SRPRA_N | 5 |
IPR007223 | 7,223 | Peroxin 13, N-terminal | Peroxin-13_N | Domain | 3,316 | false | false | Peroxin-13 is a component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor [ , , ]. This complex forms a large import pore which can be opened to a diameter of about 9 nm [ ]. Members of this group of proteins also contai... | [
"GO:0016560",
"GO:0005777",
"GO:0016020"
] | [
"protein import into peroxisome matrix, docking",
"peroxisome",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04088"
] | [
"Peroxin-13_N"
] | [
3316
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-8866654",
"R-BTA-9033241",
"R-BTA-9603798",
"R-CEL-8866654",
"R-CEL-9033241",
"R-CEL-9603798",
"R-DDI-8866654",
"R-DDI-9033241",
"R-DDI-9603798",
"R-HSA-8866654",
"R-HSA-9033241",
"R-HSA-9603798",
"R-MMU-8866654",
"R-MMU-9033241",
"R-MMU-9603798",
"R-RNO-8866654",
"R-RNO-90332... | [
"REACTOME:R-BTA-8866654",
"REACTOME:R-BTA-9033241",
"REACTOME:R-BTA-9603798",
"REACTOME:R-CEL-8866654",
"REACTOME:R-CEL-9033241",
"REACTOME:R-CEL-9603798",
"REACTOME:R-DDI-8866654",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DDI-9603798",
"REACTOME:R-HSA-8866654",
"REACTOME:R-HSA-9033241",
"REACTOM... | 24 | [] | 0 | [
"PUB00008654",
"PUB00101870",
"PUB00101939",
"PUB00101940",
"PUB00101941"
] | [
"10882522",
"28765278",
"8858165",
"20154681",
"9653144"
] | [
"Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart.",
"The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.",
"Pex13p is an SH3 protein of the peroxisome membrane and a dockin... | [
2000,
2017,
1996,
2010,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Hymenobacter duratus"
] | [
3315,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
2,
1,
1,
1,
2,
1,
1
] | 9 | true | Domain | Peroxin 13, N-terminal | Peroxin 13, N-terminal | Peroxin-13_N | 2 |
IPR007224 | 7,224 | Transcription initiation factor Rrn11, conserved region | TIF_Rrn11 | Domain | 1,184 | false | false | The RNA polymerase I specific transcription initiation factor Rrn11 is a member of a multiprotein complex essential for the initiation of transcription by RNA polymerase I, together with Rrn6 and Rrn7 subunits [ , ]. Binding to the DNA template is dependent on the initial binding of other factors [ ]. Rrn11 contains a ... | [
"GO:0001164",
"GO:0001181",
"GO:0006361"
] | [
"RNA polymerase I core promoter sequence-specific DNA binding",
"RNA polymerase I general transcription initiation factor activity",
"transcription initiation at RNA polymerase I promoter"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04090"
] | [
"Rrn11"
] | [
1184
] | 1 | [] | [] | [] | 0 | [
"5n5y",
"5n5z",
"5n60",
"5n61",
"5o7x",
"5oa1",
"5w5y",
"5w64",
"5w65",
"5w66",
"6rqh",
"6rql",
"6rrd",
"6rui",
"6ruo",
"6rwe",
"6tps"
] | 17 | [
"PUB00020262",
"PUB00099775",
"PUB00100002"
] | [
"12095692",
"28340337",
"28623663"
] | [
"Characterization of a fission yeast subunit of an RNA polymerase I essential transcription initiation factor, SpRrn7h/TAF(I)68, that bridges yeast and mammals: association with SpRrn11h and the core ribosomal RNA gene promoter.",
"Structural Basis of RNA Polymerase I Transcription Initiation.",
"Structural mec... | [
2002,
2017,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Eukaryota"
] | [
6,
1178
] | 2 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Transcription initiation factor Rrn11, conserved region | Transcription initiation factor Rrn11, conserved region | TIF_Rrn11 | 6 |
IPR007225 | 7,225 | Exocyst complex component EXOC6/Sec15 | EXOC6/Sec15 | Family | 8,538 | false | false | Sec15 is a component of the exocyst complex involved in the the tethering of post-Golgi Golgi secretory vesicles to the plasma membrane during exocytosis and plays a role in several cellular functions such as cell polarisation, cytokinesis, ciliogenesis and tumour invasion. The exocyst is one of the members of the comp... | [
"GO:0006886",
"GO:0090522"
] | [
"intracellular protein transport",
"vesicle tethering involved in exocytosis"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF025007",
"PTHR12702"
] | [
"Sec15",
""
] | [
6608,
8538
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-264876",
"R-CEL-5620916",
"R-DDI-264876",
"R-DME-264876",
"R-DME-5620916",
"R-HSA-1445148",
"R-HSA-264876",
"R-HSA-5620916",
"R-MMU-264876",
"R-MMU-5620916",
"R-RNO-264876",
"R-RNO-5620916"
] | [
"REACTOME:R-CEL-264876",
"REACTOME:R-CEL-5620916",
"REACTOME:R-DDI-264876",
"REACTOME:R-DME-264876",
"REACTOME:R-DME-5620916",
"REACTOME:R-HSA-1445148",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-5620916",
"REACTOME:R-MMU-264876",
"REACTOME:R-MMU-5620916",
"REACTOME:R-RNO-264876",
"REACTOME:R-RN... | 12 | [
"2a2f",
"5yfp",
"6vkl"
] | 3 | [
"PUB00039114",
"PUB00100047",
"PUB00100048"
] | [
"16155582",
"34061181",
"29335562"
] | [
"Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.",
"Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.",
"Cryo-EM structure of the exocyst complex."
] | [
2005,
2021,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8538
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
14,
1,
16,
13,
1,
8,
13,
1,
1,
24
] | 12 | true | Family | Exocyst complex component EXOC6/Sec15 | Exocyst complex component EXOC6/Sec15 | EXOC6/Sec15 | 3 |
IPR007226 | 7,226 | SRS domain | SRS_dom | Domain | 2,350 | false | false | Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment ... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04092"
] | [
"SAG"
] | [
2350
] | 1 | [] | [] | [] | 0 | [
"1kzq",
"1ynt",
"2jks",
"2wnk",
"2x28",
"5wa2",
"8ddp"
] | 7 | [
"PUB00020298"
] | [
"12091874"
] | [
"Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2350
] | 1 | [] | [] | 0 | true | Domain | SRS domain | SRS domain | SRS_dom | 4 |
IPR007227 | 7,227 | Cell shape-determining protein MreD | Cell_shape_determining_MreD | Family | 14,612 | false | false | The MreD (murein formation D) protein is involved in bacterial cell shape determination [ , ]. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as w... | [
"GO:0008360",
"GO:0016020"
] | [
"regulation of cell shape",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"NCBIFAM"
] | [
"PF04093",
"TIGR03426"
] | [
"MreD",
"shape_MreD"
] | [
12798,
14031
] | 2 | [
"GP"
] | [
"GenProp0166"
] | [
"GP:GenProp0166"
] | 1 | [
"9dvb",
"9dvc"
] | 2 | [
"PUB00056833",
"PUB00059314"
] | [
"2687239",
"1937035"
] | [
"New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells.",
"Sequence of the downstream flanking region of the shape-determining genes mreBCD of Escherichia coli."
] | [
1989,
1991
] | 2 | [] | [
"IPR017225",
"IPR026034"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
14241,
8,
363
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cell shape-determining protein MreD | Cell shape-determining protein MreD | Cell_shape_determining_MreD | 6 |
IPR007229 | 7,229 | Nicotinate phosphoribosyltransferase family | Nic_PRibTrfase-Fam | Family | 27,510 | false | false | Nicotinate phosphoribosyltransferase ( ) is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis [ ]. Members in this family can be split into two further subfamilies represented in and . Members in have a different (longer) spacing of several key motifs and have an additional C-termi... | [
"GO:0004516"
] | [
"nicotinate phosphoribosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000484",
"PTHR11098"
] | [
"NAPRT",
""
] | [
25705,
26232
] | 2 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.4.21",
"GenProp1296",
"PWY-5381",
"R-CEL-196807",
"R-CEL-6798695",
"R-DDI-196807",
"R-DDI-6798695",
"R-DME-196807",
"R-DME-6798695",
"R-DRE-196807",
"R-DRE-6798695",
"R-HSA-196807",
"R-HSA-6798695",
"R-MMU-196807",
"R-MMU-6798695",
"R-RNO-196807",
"R-RNO-6798695",
"R-SCE-19680... | [
"EC:6.3.4.21",
"GP:GenProp1296",
"METACYC:PWY-5381",
"REACTOME:R-CEL-196807",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-196807",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-196807",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-196807",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-196807",
"REACTOME:... | 21 | [
"1vlp",
"1ybe",
"1yir",
"1ytd",
"1yte",
"1ytk",
"2f7f",
"2i14",
"2i1o",
"2im5",
"3os4",
"4hl7",
"4mzy",
"4yub"
] | 14 | [
"PUB00067936"
] | [
"18490451"
] | [
"Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli."
] | [
2008
] | 1 | [] | [
"IPR006405",
"IPR006406",
"IPR035809"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
408,
21279,
5650,
10,
163
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
1,
3,
4,
1,
7,
2,
1,
7,
6,
1,
1,
27
] | 13 | true | Family | Nicotinate phosphoribosyltransferase family | Nicotinate phosphoribosyltransferase family | Nic_PRibTrfase-Fam | 6 |
IPR007230 | 7,230 | Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain | Nup98_auto-Pept-S59_dom | Domain | 7,562 | false | false | Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport in eukaryotic cells, playing essential roles in cellular homeostasis. The NPC is a modular structure composed of multiple copies of ~30 proteins (nucleoporins, Nups) arranged into distinct subcomplexes [ , ]. A number of these peptides are synthes... | [
"GO:0017056",
"GO:0006913",
"GO:0005643"
] | [
"structural constituent of nuclear pore",
"nucleocytoplasmic transport",
"nuclear pore"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF04096",
"PS51434"
] | [
"Nucleoporin2",
"NUP_C"
] | [
7435,
7543
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-9615933",
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-HSA-141444",
"R-HSA-159227",
"R-HSA-159230",
"... | [
"REACTOME:R-CEL-9615933",
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-D... | 108 | [
"1ko6",
"2aiv",
"2q5x",
"2q5y",
"3kep",
"3kes",
"3nf5",
"3pbp",
"3tkn",
"5cww",
"5e0q",
"5hb5",
"5hb6",
"7f60",
"7f90",
"7fik",
"7mni",
"7now",
"7nq6",
"7nqa",
"7r5j",
"7r5k",
"7tbi",
"7tbl",
"7tbm",
"8tie",
"9hcj"
] | 27 | [
"PUB00011901",
"PUB00011902",
"PUB00019948",
"PUB00039297",
"PUB00050622",
"PUB00062537",
"PUB00099726",
"PUB00099727",
"PUB00099728",
"PUB00099729",
"PUB00099730",
"PUB00106933"
] | [
"10542288",
"12191480",
"12191467",
"16105837",
"18160040",
"20310066",
"30943044",
"33159083",
"33247142",
"21326946",
"19855394",
"28221134"
] | [
"Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor.",
"The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98.",
"Cleave to leave: structural insights into the dynamic organization of the nuclear pore complex.",
"Multiple conformat... | [
1999,
2002,
2002,
2005,
2007,
2010,
2019,
2020,
2020,
2010,
2009,
2017
] | 12 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Coxsackievirus A4",
"Eukaryota",
"marine sediment metagenome"
] | [
28,
1,
7532,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
1,
2,
8,
15,
10,
1,
13,
5,
3,
1,
27
] | 12 | true | Domain | Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain | Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain | Nup98_auto-Pept-S59_dom | 5 |
IPR007231 | 7,231 | Nucleoporin interacting component Nup93/Nic96 | Nucleoporin_int_Nup93/Nic96 | Family | 5,593 | false | false | Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex [ ]. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1 [ ]. The structure of Nic96 has revealed a mostly α helical ... | [
"GO:0017056",
"GO:0005643"
] | [
"structural constituent of nuclear pore",
"nuclear pore"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04097",
"PTHR11225"
] | [
"Nic96",
""
] | [
5290,
5512
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-159227",
"R-BTA-159230",
"R-BTA-159231",
"R-BTA-159236",
"R-BTA-170822",
"R-BTA-191859",
"R-BTA-3108214",
"R-BTA-3232142",
"R-BTA-3301854",
"R-BTA-3371453",
"R-BTA-4085377",
"R-BTA-4551638",
"R-BTA-4570464",
"R-BTA-4615885",
"R-BTA-5578749",
"R-BTA-9615933",
"R-HSA-1169408",
... | [
"REACTOME:R-BTA-159227",
"REACTOME:R-BTA-159230",
"REACTOME:R-BTA-159231",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-170822",
"REACTOME:R-BTA-191859",
"REACTOME:R-BTA-3108214",
"REACTOME:R-BTA-3232142",
"REACTOME:R-BTA-3301854",
"REACTOME:R-BTA-3371453",
"REACTOME:R-BTA-4085377",
"REACTOME:R-BT... | 101 | [
"2qx5",
"2rfo",
"5cws",
"5hb2",
"5hb3",
"5ijn",
"5ijo",
"6x07",
"7fik",
"7mvt",
"7mvu",
"7mvv",
"7mvx",
"7mvy",
"7mvz",
"7mw0",
"7mw1",
"7n85",
"7n9f",
"7per",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7vci",
"7vop",
"7wb4",
"7wkk",
"7woo"... | 37 | [
"PUB00019923",
"PUB00044737",
"PUB00044738"
] | [
"9372936",
"17897938",
"9348540"
] | [
"Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.",
"Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture.",
"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with... | [
1997,
2007,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5593
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
2,
4,
5,
13,
3,
1,
2,
6,
1,
2,
10
] | 12 | true | Family | Nucleoporin interacting component Nup93/Nic96 | Nucleoporin interacting component Nup93/Nic96 | Nucleoporin_int_Nup93/Nic96 | 6 |
IPR007232 | 7,232 | DNA repair protein Rad52/59/22 | Rad52_Rad59_Rad22 | Family | 3,690 | false | false | The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs [ ]. | [
"GO:0006281",
"GO:0006310"
] | [
"DNA repair",
"DNA recombination"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR12132"
] | [
""
] | [
3690
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3108214",
"R-HSA-5685938",
"R-HSA-5685939",
"R-MMU-3108214",
"R-MMU-5685938",
"R-MMU-5685939",
"R-SCE-3108214",
"R-SCE-5685938",
"R-SPO-3108214",
"R-SPO-5685938"
] | [
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5685939",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5685939",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SCE-5685938",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5685938"
] | 10 | [
"1h2i",
"1kn0",
"5jrb",
"5xrz",
"5xs0",
"8bjm",
"8g3g",
"8h1p",
"8ril",
"8rj3",
"8rjw",
"8tkq"
] | 12 | [
"PUB00009986"
] | [
"11914131"
] | [
"Classification and evolutionary history of the single-strand annealing proteins, RecT, Redbeta, ERF and RAD52."
] | [
2002
] | 1 | [
"IPR041247"
] | [
"IPR004585",
"IPR016810"
] | 1 | 2 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
94,
3,
3588,
5
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
12,
4,
1,
4,
2,
2
] | 7 | true | Family | DNA repair protein Rad52/59/22 | DNA repair protein Rad52/59/22 | Rad52_Rad59_Rad22 | 7 |
IPR007233 | 7,233 | Trafficking protein particle complex subunit | TRAPPC | Family | 8,761 | false | false | This entry includes a group of trafficking protein particle complex subunit (TRAPPC) proteins, such as TPPC1/4 from humans and Trs23/Bet5 from yeasts. | [
"GO:0016192",
"GO:0030008"
] | [
"vesicle-mediated transport",
"TRAPP complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER",
"SMART"
] | [
"PF04099",
"PTHR23249",
"SM01399"
] | [
"Sybindin",
"",
"Sybindin"
] | [
8433,
8099,
8594
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-204005",
"R-BTA-6798695",
"R-BTA-8876198",
"R-DDI-204005",
"R-DDI-6798695",
"R-DDI-8876198",
"R-HSA-204005",
"R-HSA-3000170",
"R-HSA-6798695",
"R-HSA-8876198",
"R-MMU-204005",
"R-MMU-6798695",
"R-MMU-8876198",
"R-RNO-204005",
"R-RNO-6798695",
"R-RNO-8876198",
"R-SCE-204005",
... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8876198",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-8876198",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-3000170",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-204005",
"REACTOME:R-... | 22 | [
"2j3t",
"2zmv",
"3cue",
"7b6d",
"7b6r",
"7b6x",
"7b70",
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7kmt",
"7u05",
"7u06"
] | 17 | [
"PUB00055557",
"PUB00056043",
"PUB00078813"
] | [
"11239471",
"20375281",
"20972447"
] | [
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.",
"Molecular architecture of the TRAPPII complex and implications for vesicle tethering."
] | [
2001,
2010,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
8760,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
2,
3,
2,
14,
7,
3,
11,
17,
2,
3,
16
] | 12 | true | Family | Trafficking protein particle complex subunit | Trafficking protein particle complex subunit | TRAPPC | 4 |
IPR007234 | 7,234 | Vps53, N-terminal | Vps53_N | Domain | 5,744 | false | false | Vps53 complexes with Vps52 and Vps54 to form a multi-subunit complex called Golgi-Associated Retrograde Protein complex (GARP) involved in retrograde transport from early and late endosomes to late Golgi [ , , ]. They are members of the CATCHR (complexes associated with tethering containing helical rods) which includes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04100"
] | [
"Vps53_N"
] | [
5744
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-6811440",
"R-HSA-6811440",
"R-MMU-6811440"
] | [
"REACTOME:R-GGA-6811440",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440"
] | 3 | [] | 0 | [
"PUB00010592",
"PUB00100038",
"PUB00100047"
] | [
"10637310",
"20660722",
"34061181"
] | [
"Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi.",
"Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes.",
"Homology and Modular Evo... | [
2000,
2010,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5744
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
1,
3,
2,
42,
11,
1,
1,
5,
1,
1,
7
] | 12 | true | Domain | Vps53, N-terminal | Vps53, N-terminal | Vps53_N | 7 |
IPR007235 | 7,235 | Glycosyl transferase, family 28, C-terminal | Glyco_trans_28_C | Domain | 47,679 | false | false | The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferas... | [
"GO:0016758"
] | [
"hexosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04101"
] | [
"Glyco_tran_28_C"
] | [
47679
] | 1 | [
"CAZY",
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GT28",
"2.4.1",
"2.4.1.227",
"GenProp1302",
"PWY-5265",
"PWY-6385",
"PWY-6470",
"PWY-6471",
"R-HSA-446193",
"R-HSA-5633231",
"R-RNO-446193",
"R-SPO-446193"
] | [
"CAZY:GT28",
"EC:2.4.1",
"EC:2.4.1.227",
"GP:GenProp1302",
"METACYC:PWY-5265",
"METACYC:PWY-6385",
"METACYC:PWY-6470",
"METACYC:PWY-6471",
"REACTOME:R-HSA-446193",
"REACTOME:R-HSA-5633231",
"REACTOME:R-RNO-446193",
"REACTOME:R-SPO-446193"
] | 12 | [
"1f0k",
"1nlm",
"2jzc",
"2ks6",
"3s2u",
"4wyi",
"4x1t",
"7d1i"
] | 8 | [
"PUB00009409"
] | [
"9334165"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities."
] | [
1997
] | 1 | [] | [
"IPR048097"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctKHS5",
"unclassified sequences"
] | [
386,
39507,
7011,
1,
774
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
23,
1,
1,
2,
1,
8,
5,
2,
14,
2,
1,
1,
24
] | 13 | true | Domain | Glycosyl transferase, family 28, C-terminal | Glycosyl transferase, family 28, C-terminal | Glyco_trans_28_C | 5 |
IPR007236 | 7,236 | SlyX | SlyX | Family | 7,281 | false | false | The SlyX protein has no known function. It is short, less than 80 amino acids, and its gene is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C terminus. The protein may be a coiled-coil structure. | [] | [] | [] | 0 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_00715",
"PF04102",
"PTHR36508"
] | [
"SlyX",
"SlyX",
""
] | [
4487,
7281,
6040
] | 3 | [] | [] | [] | 0 | [
"3efg"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Gordonia phage Avazak",
"Halobacteriales",
"metagenomes"
] | [
7177,
7,
1,
21,
75
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | SlyX | SlyX | SlyX | 9 |
IPR007237 | 7,237 | CD20-like, transmembrane domain | CD20-like_TM | Domain | 11,487 | false | false | This entry represents the multipass transmembrane domain of B-lymphocyte antigen CD20 and other members of the membrane-spanning 4-domains subfamily A (MS4A), and closely related TMEM176 proteins [ , ]. It also includes sarcospan and some uncharacterised proteins. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04103"
] | [
"CD20"
] | [
11487
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2454202",
"R-HSA-2730905",
"R-HSA-2871796",
"R-HSA-2871809",
"R-HSA-2871837",
"R-HSA-6798695",
"R-HSA-9913351",
"R-MMU-2454202",
"R-MMU-2730905",
"R-MMU-2871796",
"R-MMU-2871809",
"R-MMU-2871837",
"R-MMU-6798695",
"R-MMU-9913351",
"R-RNO-2454202",
"R-RNO-2730905",
"R-RNO-28717... | [
"REACTOME:R-HSA-2454202",
"REACTOME:R-HSA-2730905",
"REACTOME:R-HSA-2871796",
"REACTOME:R-HSA-2871809",
"REACTOME:R-HSA-2871837",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9913351",
"REACTOME:R-MMU-2454202",
"REACTOME:R-MMU-2730905",
"REACTOME:R-MMU-2871796",
"REACTOME:R-MMU-2871809",
"REACTOM... | 19 | [
"6vja",
"6y90",
"6y92",
"6y97",
"6y9a",
"8k7t",
"8vgn",
"8vgo",
"8y81",
"8y84",
"8yrj",
"8yt8",
"8yvu",
"8ywa",
"8zgs",
"8zgt",
"9c3c"
] | 17 | [
"PUB00053411",
"PUB00072758",
"PUB00072760",
"PUB00072762",
"PUB00072763"
] | [
"10441321",
"11245982",
"11401424",
"23874341",
"20186339"
] | [
"Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice.",
"Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.",
"Identification of a CD20-, FcepsilonRIbeta-, and HTm4-... | [
1999,
2001,
2001,
2013,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eumetazoa"
] | [
131,
5,
11351
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
80,
2,
73,
71,
74
] | 6 | true | Domain | CD20-like, transmembrane domain | CD20-like, transmembrane domain | CD20-like_TM | 4 |
IPR007238 | 7,238 | DNA primase large subunit, eukaryotic/archaeal | DNA_primase_lsu_euk/arc | Family | 5,854 | false | false | DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archa... | [
"GO:0006269"
] | [
"DNA replication, synthesis of primer"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR10537"
] | [
""
] | [
5854
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-113501",
"R-CEL-68952",
"R-CEL-68962",
"R-CEL-69091",
"R-CEL-69166",
"R-CEL-69183",
"R-DDI-113501",
"R-DDI-68952",
"R-DDI-68962",
"R-DDI-69091",
"R-DDI-69166",
"R-DDI-69183",
"R-DME-113501",
"R-DME-68952",
"R-DME-68962",
"R-DME-69091",
"R-DME-69166",
"R-DME-69183",
"R-HSA-... | [
"REACTOME:R-CEL-113501",
"REACTOME:R-CEL-68952",
"REACTOME:R-CEL-68962",
"REACTOME:R-CEL-69091",
"REACTOME:R-CEL-69166",
"REACTOME:R-CEL-69183",
"REACTOME:R-DDI-113501",
"REACTOME:R-DDI-68952",
"REACTOME:R-DDI-68962",
"REACTOME:R-DDI-69091",
"REACTOME:R-DDI-69166",
"REACTOME:R-DDI-69183",
"R... | 55 | [
"3l9q",
"3lgb",
"3q36",
"4bpu",
"4bpw",
"4bpx",
"4rr2",
"5dqo",
"5exr",
"5f0q",
"5f0s",
"5i7m",
"6dhw",
"6di2",
"6di6",
"6dtv",
"6dtz",
"6du0",
"7opl",
"7tl2",
"7tl3",
"7tl4",
"7u5c",
"7uy8",
"8b9a",
"8b9b",
"8b9c",
"8b9d",
"8d0b",
"8d0k",
"8d96",
"8d9d"... | 53 | [
"PUB00005693",
"PUB00009835",
"PUB00009837",
"PUB00039010"
] | [
"2023935",
"2528682",
"8026492",
"16273105"
] | [
"Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.",
"A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae.",
"DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.",
"Structure of the heterodimeric core primase."
] | [
1991,
1989,
1994,
2005
] | 4 | [] | [
"IPR016558",
"IPR023642"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Methanophagales virus PBV300",
"ecological metagenomes"
] | [
556,
2,
5273,
1,
22
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
2,
3,
2,
8,
3,
1,
3,
4,
1,
1,
10
] | 12 | true | Family | DNA primase large subunit, eukaryotic/archaeal | DNA primase large subunit, eukaryotic/archaeal | DNA_primase_lsu_euk/arc | 8 |
IPR007239 | 7,239 | Autophagy-related protein 5 | Atg5 | Family | 4,968 | false | false | This entry represents autophagy protein 5 (Atg5). Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16... | [
"GO:0006914",
"GO:0005737"
] | [
"autophagy",
"cytoplasm"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR13040"
] | [
""
] | [
4968
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1632852",
"R-BTA-5205685",
"R-BTA-8934903",
"R-CEL-1632852",
"R-CEL-5205685",
"R-CEL-8934903",
"R-DDI-1632852",
"R-DDI-5205685",
"R-DDI-8934903",
"R-DME-1632852",
"R-HSA-1632852",
"R-HSA-5205685",
"R-HSA-8934903",
"R-HSA-936440",
"R-MMU-1632852",
"R-MMU-5205685",
"R-MMU-893490... | [
"REACTOME:R-BTA-1632852",
"REACTOME:R-BTA-5205685",
"REACTOME:R-BTA-8934903",
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-5205685",
"REACTOME:R-CEL-8934903",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-5205685",
"REACTOME:R-DDI-8934903",
"REACTOME:R-DME-1632852",
"REACTOME:R-HSA-1632852",
"REACTOM... | 24 | [
"2dym",
"2dyo",
"3vqi",
"3w1s",
"4gdk",
"4gdl",
"4naw",
"4tq0",
"4tq1",
"5d7g",
"5npv",
"5npw",
"7w36"
] | 13 | [
"PUB00009838",
"PUB00009839",
"PUB00033271",
"PUB00097434"
] | [
"10712513",
"11689437",
"10406794",
"2306415"
] | [
"Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways.",
"The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.",
"Apg16p is required for the function of the Apg12p-Apg5p conjugate in the ye... | [
2000,
2001,
1999,
1990
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4968
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
8,
3,
1,
2,
6,
1,
1,
8
] | 12 | true | Family | Autophagy-related protein 5 | Autophagy-related protein 5 | Atg5 | 4 |
IPR007240 | 7,240 | Autophagy-related protein 17 | Atg17 | Family | 1,617 | false | false | Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [ , ]. The C-terminal glyc... | [
"GO:0006914"
] | [
"autophagy"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR28005"
] | [
""
] | [
1617
] | 1 | [] | [] | [] | 0 | [
"4hpq",
"4p1w",
"5jhf"
] | 3 | [
"PUB00009838",
"PUB00009839",
"PUB00033271",
"PUB00076874",
"PUB00097434"
] | [
"10712513",
"11689437",
"10406794",
"23219485",
"2306415"
] | [
"Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways.",
"The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.",
"Apg16p is required for the function of the Apg12p-Apg5p conjugate in the ye... | [
2000,
2001,
1999,
2012,
1990
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1617
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Autophagy-related protein 17 | Autophagy-related protein 17 | Atg17 | 4 |
IPR007242 | 7,242 | Ubiquitin-like protein Atg12 | Atg12 | Family | 3,953 | false | false | Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [ , ]. The C-terminal glyc... | [
"GO:0000045",
"GO:0005737"
] | [
"autophagosome assembly",
"cytoplasm"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04110",
"PTHR13385"
] | [
"APG12",
""
] | [
3950,
3801
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1632852",
"R-CEL-5205685",
"R-CEL-8934903",
"R-DDI-1632852",
"R-DDI-5205685",
"R-DDI-8934903",
"R-DME-1632852",
"R-HSA-1632852",
"R-HSA-5205685",
"R-HSA-8934903",
"R-HSA-936440",
"R-MMU-1632852",
"R-MMU-5205685",
"R-MMU-8934903",
"R-RNO-1632852",
"R-RNO-5205685",
"R-RNO-893490... | [
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-5205685",
"REACTOME:R-CEL-8934903",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-5205685",
"REACTOME:R-DDI-8934903",
"REACTOME:R-DME-1632852",
"REACTOME:R-HSA-1632852",
"REACTOME:R-HSA-5205685",
"REACTOME:R-HSA-8934903",
"REACTOME:R-HSA-936440",
"REACTOME... | 21 | [
"1wz3",
"3w1s",
"4gdk",
"4gdl",
"4naw",
"7eu4"
] | 6 | [
"PUB00009838",
"PUB00009839",
"PUB00009842",
"PUB00033271",
"PUB00097434"
] | [
"10712513",
"11689437",
"9852036",
"10406794",
"2306415"
] | [
"Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways.",
"The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.",
"A new protein conjugation system in human. The counterpart of the yeast Apg... | [
2000,
2001,
1998,
1999,
1990
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3953
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
3,
1,
3,
1,
1,
1,
5,
1,
1,
3
] | 12 | true | Family | Ubiquitin-like protein Atg12 | Ubiquitin-like protein Atg12 | Atg12 | 6 |
IPR007243 | 7,243 | Atg6/Beclin | Atg6/Beclin | Family | 5,616 | false | false | In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 lin... | [
"GO:0006914"
] | [
"autophagy"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR12768"
] | [
""
] | [
5616
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169408",
"R-BTA-1632852",
"R-BTA-5689880",
"R-CEL-1169408",
"R-CEL-1632852",
"R-DDI-1169408",
"R-DDI-1632852",
"R-DDI-5689880",
"R-DME-1169408",
"R-DME-1632852",
"R-DME-5689880",
"R-DRE-5689880",
"R-HSA-1169408",
"R-HSA-1632852",
"R-HSA-5689880",
"R-HSA-9679504",
"R-HSA-96946... | [
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-1632852",
"REACTOME:R-BTA-5689880",
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-1632852",
"REACTOME:R-DDI-1169408",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-5689880",
"REACTOME:R-DME-1169408",
"REACTOME:R-DME-1632852",
"REACTOME:R-DME-5689880",
"REACTOM... | 30 | [
"3q8t",
"3vp7",
"4ddp",
"5dfz",
"5hhe",
"5k7b",
"5k9l",
"7bl1",
"8gt9",
"8gu7",
"8sor",
"9c82",
"9mhf",
"9mhg",
"9mhh"
] | 15 | [
"PUB00069993",
"PUB00069995",
"PUB00069997"
] | [
"21311563",
"22437838",
"22170155"
] | [
"The Beclin 1 network regulates autophagy and apoptosis.",
"Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.",
"Beclin1: a role in membrane dynamics and beyond."
] | [
2011,
2012,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactobacillales",
"Viruses"
] | [
5601,
8,
7
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
13,
6,
1,
8,
5,
1,
1,
19
] | 12 | true | Family | Atg6/Beclin | Atg6/Beclin | Atg6/Beclin | 7 |
IPR007244 | 7,244 | NAA35-like | Naa35_N | Family | 5,268 | false | false | In budding yeasts, NatC N(alpha)-terminal acetyltransferases contain Mak10, Mak31 and Mak3 subunits. All three subunits are associated with each other to form the active complex [ ]. Naa35, also known as MAK10, catalyses acetylation of the N-terminal Met of the L-A virus Gag protein. MAK10 has a role in the propagation... | [
"GO:0017196",
"GO:0031417"
] | [
"N-terminal peptidyl-methionine acetylation",
"NatC complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR21373"
] | [
""
] | [
5268
] | 1 | [
"GP",
"REACTOME"
] | [
"GenProp1491",
"R-HSA-6811440"
] | [
"GP:GenProp1491",
"REACTOME:R-HSA-6811440"
] | 2 | [
"6yga",
"6ygb",
"6ygc",
"6ygd",
"7l1k",
"7mx2",
"7rb3"
] | 7 | [
"PUB00009844",
"PUB00091098",
"PUB00155198"
] | [
"11274203",
"19398576",
"37891180"
] | [
"NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p.",
"Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.",
"N-terminal acetylation shields proteins from degradation and promotes... | [
2001,
2009,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5268
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
1,
2,
2,
7,
1,
3,
7,
1,
1,
12
] | 12 | true | Family | NAA35-like | NAA35-like | Naa35_N | 6 |
IPR007245 | 7,245 | GPI transamidase component PIG-T | PIG-T | Family | 5,602 | false | false | Phosphatidylinositol-glycan biosynthesis class T protein (PIG-T, also known as Gpi16 in budding yeasts) is a component of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [ ]. Mammalian GPI transamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG... | [
"GO:0016255",
"GO:0042765"
] | [
"attachment of GPI anchor to protein",
"GPI-anchor transamidase complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04113",
"PTHR12959"
] | [
"Gpi16",
""
] | [
5578,
5517
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-162791",
"R-MMU-162791"
] | [
"REACTOME:R-HSA-162791",
"REACTOME:R-MMU-162791"
] | 2 | [
"7w72",
"7wld",
"8imx",
"8imy"
] | 4 | [
"PUB00009845",
"PUB00044439"
] | [
"11598210",
"14660601"
] | [
"The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p.",
"A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase."
] | [
2001,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5602
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
2,
3,
1,
43,
5,
1,
4,
6,
1,
1,
8
] | 12 | true | Family | GPI transamidase component PIG-T | GPI transamidase component PIG-T | PIG-T | 8 |
IPR007246 | 7,246 | GPI transamidase component Gaa1 | Gaa1 | Family | 4,647 | false | false | GPI (glycosyl phosphatidyl inositol) transamidase is a multiprotein complex required for a terminal step of adding the glycosylphosphatidylinositol (GPI) anchor attachment onto proteins. Gpi16, Gpi8 and Gaa1 form a sub-complex of the GPI transamidase. | [
"GO:0016020",
"GO:0042765"
] | [
"membrane",
"GPI-anchor transamidase complex"
] | [
"cellular_component",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04114",
"PIRSF036762",
"PTHR13304"
] | [
"Gaa1",
"GAA1",
""
] | [
4536,
2757,
4502
] | 3 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-162791",
"R-MMU-162791"
] | [
"REACTOME:R-HSA-162791",
"REACTOME:R-MMU-162791"
] | 2 | [
"7w72",
"7wld",
"8imx",
"8imy"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4647
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
9,
3,
3,
27,
4,
1,
3,
5,
1,
1,
11
] | 12 | true | Family | GPI transamidase component Gaa1 | GPI transamidase component Gaa1 | Gaa1 | 9 |
IPR007247 | 7,247 | Ureidoglycolate lyase | Ureidogly_lyase | Family | 7,663 | false | false | Ureidoglycolate lyase ( ) is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. It breaks down (S)-ureidoglycolate to produce glyoxylate and urea [ ]. This family of ureidoglycolate lyases were initially annotated as ureidoglycolate hydrolases, but this has since been corrected [ ]. | [
"GO:0050385",
"GO:0000256"
] | [
"ureidoglycolate lyase activity",
"allantoin catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04115",
"PIRSF017306",
"PTHR21221"
] | [
"Ureidogly_lyase",
"Ureidogly_hydro",
""
] | [
7663,
4456,
6125
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC"
] | [
"4.3.2.3",
"GenProp0686",
"GenProp1257",
"GenProp1416",
"PWY-5694",
"PWY-5705"
] | [
"EC:4.3.2.3",
"GP:GenProp0686",
"GP:GenProp1257",
"GP:GenProp1416",
"METACYC:PWY-5694",
"METACYC:PWY-5705"
] | 6 | [
"1xsq",
"1xsr",
"1yqc",
"2bdr"
] | 4 | [
"PUB00074208",
"PUB00078751"
] | [
"24107613",
"19935661"
] | [
"Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa.",
"Ureide catabolism in Arabidopsis thaliana and Escherichia coli."
] | [
2013,
2010
] | 2 | [] | [
"IPR023525"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA259A05",
"unclassified sequences"
] | [
5659,
1914,
1,
89
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1,
1
] | 4 | true | Family | Ureidoglycolate lyase | Ureidoglycolate lyase | Ureidogly_lyase | 1 |
IPR007248 | 7,248 | Mpv17/PMP22 | Mpv17_PMP22 | Family | 24,292 | false | false | The 22kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by ... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04117",
"PTHR11266"
] | [
"Mpv17_PMP22",
""
] | [
22553,
23450
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9033241",
"R-CEL-9033241",
"R-DDI-9033241",
"R-DDI-9603798",
"R-DME-9033241",
"R-HSA-389661",
"R-HSA-9033241",
"R-HSA-9603798",
"R-MMU-9033241",
"R-MMU-9603798",
"R-RNO-9033241",
"R-RNO-9603798",
"R-SCE-9033241",
"R-SPO-9033241"
] | [
"REACTOME:R-BTA-9033241",
"REACTOME:R-CEL-9033241",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DDI-9603798",
"REACTOME:R-DME-9033241",
"REACTOME:R-HSA-389661",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9603798",
"REACTOME:R-MMU-9033241",
"REACTOME:R-MMU-9603798",
"REACTOME:R-RNO-9033241",
"REACTOME... | 14 | [] | 0 | [
"PUB00009846",
"PUB00009847",
"PUB00015286",
"PUB00101094",
"PUB00101095"
] | [
"11590176",
"11327696",
"15189984",
"18227279",
"26760297"
] | [
"Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes.",
"Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family.",
"SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mamm... | [
2002,
2001,
2004,
2008,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Candidatus Kerfeldbacteria bacterium CG08_land_8_20_14_0_20_40_16",
"Eukaryota",
"Megaviricetes",
"viral metagenome"
] | [
2,
24280,
9,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
48,
2,
9,
25,
18,
14,
6,
27,
19,
2,
2,
37
] | 12 | true | Family | Mpv17/PMP22 | Mpv17/PMP22 | Mpv17_PMP22 | 9 |
IPR007252 | 7,252 | Nuclear pore protein 84/107 | Nup84/Nup107 | Family | 5,532 | false | false | Nup84 forms a complex with five proteins, including Nup120, Nup85, Sec13, and a Sec13 homologue. This Nup84 complex in conjunction with Sec13-type proteins is required for correct nuclear pore biogenesis [ ]. Nup107 is the vertebrate homologue of Nup84. The Nup107-160 complex (Nup84 complex in yeast) forms the cytoplas... | [
"GO:0017056",
"GO:0005643"
] | [
"structural constituent of nuclear pore",
"nuclear pore"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04121",
"PTHR13003"
] | [
"Nup84_Nup100",
""
] | [
5367,
5380
] | 2 | [
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2036",
"GenProp2037",
"GenProp2043",
"R-CEL-9615933",
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-H... | [
"GP:GenProp2036",
"GP:GenProp2037",
"GP:GenProp2043",
"REACTOME:R-CEL-9615933",
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME... | 111 | [
"3cqc",
"3cqg",
"3i4r",
"3iko",
"3jro",
"4xmm",
"4xmn",
"5a9q",
"6lk8",
"6x02",
"6x03",
"7fik",
"7n84",
"7n9f",
"7peq",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7tdz",
"7vci",
"7vop",
"7wb4",
"8tie",
"9hcj",
"9sob"
] | 29 | [
"PUB00009851",
"PUB00087280"
] | [
"8565072",
"24315095"
] | [
"A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores.",
"Integrated structural analysis of the human nuclear pore complex scaffold."
] | [
1996,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5532
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
12,
3,
5,
1,
4,
11,
1,
1,
53
] | 12 | true | Family | Nuclear pore protein 84/107 | Nuclear pore protein 84/107 | Nup84/Nup107 | 6 |
IPR007253 | 7,253 | Cell wall binding repeat 2 | Cell_wall-bd_2 | Repeat | 6,522 | false | false | This repeat, also known as CWB2, is found in multiple tandem copies in proteins including amidase enhancers [ ], N-acetylmuramoyl-L-alanine amidase LytC [ ] and adhesins [ ]. CWB2 is found in Cwp8 protein from C. difficile whose structure was determined [ ]. Cwp8 contains 3 CWB2 arranged in triangular trimer. Each CWB2... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04122"
] | [
"CW_binding_2"
] | [
6522
] | 1 | [] | [] | [] | 0 | [
"5j6q",
"5j72",
"7acx",
"7acy",
"7acz",
"7qgq",
"8bby",
"9f8e",
"9f8f"
] | 9 | [
"PUB00009852",
"PUB00009853",
"PUB00106918",
"PUB00154387",
"PUB00154388"
] | [
"1356138",
"11254569",
"28132783",
"35217634",
"19542270"
] | [
"Molecular cloning and sequencing of the upstream region of the major Bacillus subtilis autolysin gene: a modifier protein exhibiting sequence homology to the major autolysin and the spoIID product.",
"Characterization of a cell surface protein of Clostridium difficile with adhesive properties.",
"The CWB2 Cell... | [
1992,
2001,
2017,
2022,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"Siphoviridae sp. ctNs77",
"ecological metagenomes"
] | [
79,
6379,
4,
1,
59
] | 5 | [] | [] | 0 | true | Repeat | Cell wall binding repeat 2 | Cell wall binding repeat 2 | Cell_wall-bd_2 | 2 |
IPR007254 | 7,254 | Protein of unknown function DUF373 | DUF373 | Family | 1,211 | false | false | This family consists of functionally uncharacterised archaeal proteins with six transmembrane regions including AF_2058 and MJ1032. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04123",
"PTHR38815"
] | [
"DUF373",
""
] | [
1211,
1205
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria candidate phyla",
"ecological metagenomes"
] | [
1177,
2,
32
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF373 | Protein of unknown function DUF373 | DUF373 | 2 |
IPR007255 | 7,255 | Conserved oligomeric Golgi complex subunit 8 | COG8 | Family | 4,740 | false | false | Conserved oligomeric Golgi complex subunit 8 acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking [ ]. | [
"GO:0017119"
] | [
"Golgi transport complex"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04124",
"PTHR21311"
] | [
"Dor1",
""
] | [
4627,
4625
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6807878",
"R-CEL-6811438",
"R-DDI-6807878",
"R-DDI-6811438",
"R-DME-6807878",
"R-DME-6811438",
"R-DME-6811440",
"R-HSA-6807878",
"R-HSA-6811438",
"R-HSA-6811440",
"R-MMU-6807878",
"R-MMU-6811438",
"R-MMU-6811440"
] | [
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811438",
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-6811438",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811438",
"REACTOME:R-DME-6811440",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-6811438",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6807878",
"REACTOM... | 13 | [] | 0 | [
"PUB00009854"
] | [
"11703943"
] | [
"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
] | [
2001
] | 1 | [] | [
"IPR016632"
] | 0 | 1 | 0 | [
"Bacillati",
"Eukaryota"
] | [
3,
4737
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
8,
4,
1,
2,
3,
1,
1,
27
] | 12 | true | Family | Conserved oligomeric Golgi complex subunit 8 | Conserved oligomeric Golgi complex subunit 8 | COG8 | 1 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.