interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR007256 | 7,256 | TM1367-like | TM1367-like | Family | 86 | false | false | This entry represents a group of proteins from bacteria and archaea, including TM1367 from Thermotoga maritima ( ) and AF2241 from Archaeoglobus fulgidus ( ). These proteins show cyclophilin-like assemblies but lack the conserved residues related to the peptidylprolyl isomerase (PPIase) activity typical of the enzyme C... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF006456"
] | [
"UCP006456"
] | [
86
] | 1 | [] | [] | [] | 0 | [
"1zx8",
"2ka0",
"2nnz"
] | 3 | [
"PUB00039053",
"PUB00048358"
] | [
"16544291",
"17610131"
] | [
"Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold.",
"Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold."
] | [
2006,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"marine sediment metagenome"
] | [
57,
21,
8
] | 3 | [] | [] | 0 | true | Family | TM1367-like | TM1367-like | TM1367-like | 2 |
IPR007258 | 7,258 | Vps52 | Vps52 | Family | 5,318 | false | false | Vps52 complexes with Vps53 and Vps54 to form the Golgi-associated retrograde protein (GARP) complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network, regulating membrane trafficking events [ , , ]. It is also part of the EARP (Endosome-Associated Recycling Protein) compl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14190"
] | [
""
] | [
5318
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-6811440",
"R-HSA-6811440",
"R-MMU-6811440",
"R-RNO-6811440"
] | [
"REACTOME:R-CFA-6811440",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440",
"REACTOME:R-RNO-6811440"
] | 4 | [] | 0 | [
"PUB00010592",
"PUB00077150",
"PUB00090044",
"PUB00090076"
] | [
"10637310",
"25799061",
"18367545",
"15878329"
] | [
"Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi.",
"EARP is a multisubunit tethering complex involved in endocytic recycling.",
"Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes... | [
2000,
2015,
2008,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
5316,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
2,
2,
10,
4,
1,
7,
3,
1,
1,
33
] | 12 | true | Family | Vps52 | Vps52 | Vps52 | 3 |
IPR007259 | 7,259 | Gamma-tubulin complex component protein | GCP | Family | 23,722 | false | false | The microtubule organizing centres (MTOCs) of eukaryotic cells are the sites of nucleation of microtubules, and are known as the centrosome in animal cells and the spindle pole body in yeast. Gamma-tubulin, which is 30% identical to alpha and beta tubulins that form microtubules, appears to be a key protein involved in... | [
"GO:0043015",
"GO:0000226",
"GO:0007020",
"GO:0000922",
"GO:0005815"
] | [
"gamma-tubulin binding",
"microtubule cytoskeleton organization",
"microtubule nucleation",
"spindle pole",
"microtubule organizing center"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component",
"cellular_component"
] | 5 | [
"PANTHER"
] | [
"PTHR19302"
] | [
""
] | [
23722
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-380270",
"R-HSA-380320",
"R-MMU-380270",
"R-MMU-380320"
] | [
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380320",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380320"
] | 4 | [
"3rip",
"5flz",
"5fm1",
"6tf9",
"6v69",
"6v6b",
"6v6c",
"6v6s",
"6x0u",
"6x0v",
"7anz",
"7as4",
"7m2w",
"7m2x",
"7m2y",
"7m2z",
"7qj0",
"7qj1",
"7qj2",
"7qj3",
"7qj4",
"7qj5",
"7qj6",
"7qj7",
"7qj8",
"7qj9",
"7qja",
"7qjb",
"7qjc",
"7qjd",
"7qje",
"8q62"... | 52 | [
"PUB00015122",
"PUB00045134",
"PUB00078445",
"PUB00078450",
"PUB00078451"
] | [
"11950928",
"11134079",
"23132930",
"24075308",
"21993292"
] | [
"Reconstitution and characterization of budding yeast gamma-tubulin complex.",
"Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits.",
"The where, when and how of microtubule nucleation - one ring to rule them all.",
"A ring for all: γ-tubulin-containing nucleation complexes ... | [
2002,
2000,
2012,
2013,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Shewanella electrica"
] | [
23721,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
43,
2,
9,
22,
40,
25,
5,
22,
23,
2,
3,
77
] | 12 | true | Family | Gamma-tubulin complex component protein | Gamma-tubulin complex component protein | GCP | 9 |
IPR007260 | 7,260 | Putative N-acetylmannosamine-6-phosphate epimerase | NanE | Family | 6,608 | false | false | This family represents a putative epimerase that converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6P) in the N-acetylmannosamine utilization pathway, found mainly in pathogenic bacteria. It is encoded by the yhcJ/nanE gene [ ]. This reaction is part of the pathway that al... | [
"GO:0047465",
"GO:0006051"
] | [
"N-acylglucosamine-6-phosphate 2-epimerase activity",
"N-acetylmannosamine metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PANTHER",
"CDD"
] | [
"MF_01235",
"NF002231",
"PF04131",
"PTHR36204",
"cd04729"
] | [
"ManNAc6P_epimer",
"PRK01130.1",
"NanE",
"",
"NanE"
] | [
5732,
6390,
6588,
6582,
5815
] | 5 | [
"EC"
] | [
"5.1.3.9"
] | [
"EC:5.1.3.9"
] | 1 | [
"1y0e",
"1yxy",
"3igs",
"3q58",
"4utt",
"4utu",
"4utw",
"5zjb",
"5zjn",
"5zjp",
"5zkn",
"6vva",
"7mfn",
"7mfs",
"7mqt"
] | 15 | [
"PUB00019912",
"PUB00081071"
] | [
"9864311",
"10419949"
] | [
"Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli.",
"Cloning, sequence, and transcriptional regulation of the operon encoding a putative N-acetylmannosamine-6-phosphate epimerase (nanE) and sialic acid lyase (nanA) i... | [
1999,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA259E17",
"unclassified sequences"
] | [
6573,
9,
1,
25
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Putative N-acetylmannosamine-6-phosphate epimerase | Putative N-acetylmannosamine-6-phosphate epimerase | NanE | 2 |
IPR007262 | 7,262 | Vps55/LEPROT | Vps55/LEPROT | Family | 5,816 | false | false | This entry includes Vps55 from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals. Both Vps55 and OB-RGRP are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [ ]. Vps55 is involved in the secretion of the Golgi form of the soluble vacuola... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04133",
"PTHR12050"
] | [
"Vps55",
""
] | [
5813,
5621
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009857",
"PUB00092550",
"PUB00092551"
] | [
"12006663",
"27106118",
"19907080"
] | [
"Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.",
"Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO.",
"LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone acti... | [
2002,
2016,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
5812
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
2,
2,
14,
4,
1,
7,
8,
1,
1,
11
] | 12 | true | Family | Vps55/LEPROT | Vps55/LEPROT | Vps55/LEPROT | 8 |
IPR007263 | 7,263 | DCC1-like thiol-disulfide oxidoreductase family | DCC1-like | Family | 15,950 | false | false | Members of this family have two highly conserved cysteine residues within the DxxCxxC motif at the N-terminal. This motif is conserved in the thiol-disulfide oxidoreductase family [ ]. This family includes At5g50100 (also known as DCC1) from Arabidopsis thaliana, a thioredoxin that modulates ROS homeostasis resulting i... | [
"GO:0015035"
] | [
"protein-disulfide reductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04134"
] | [
"DCC1-like"
] | [
15950
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096851"
] | [
"28724620"
] | [
"Thioredoxin-Mediated ROS Homeostasis Explains Natural Variation in Plant Regeneration."
] | [
2018
] | 1 | [] | [
"IPR044691"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
493,
12944,
2298,
215
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
7,
13
] | 3 | true | Family | DCC1-like thiol-disulfide oxidoreductase family | DCC1-like thiol-disulfide oxidoreductase family | DCC1-like | 3 |
IPR007264 | 7,264 | H/ACA ribonucleoprotein complex, subunit Nop10 | H/ACA_rnp_Nop10 | Family | 3,887 | false | false | H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular pr... | [
"GO:0030515",
"GO:0001522",
"GO:0042254"
] | [
"snoRNA binding",
"pseudouridine synthesis",
"ribosome biogenesis"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04135",
"PTHR13305"
] | [
"Nop10p",
""
] | [
3872,
3261
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-171319",
"R-HSA-6790901",
"R-MMU-171319"
] | [
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-6790901",
"REACTOME:R-MMU-171319"
] | 3 | [
"1y2y",
"2apo",
"2aqa",
"2aqc",
"2aus",
"2ey4",
"2hvy",
"2rfk",
"3hax",
"3hay",
"3hjw",
"3hjy",
"3lwo",
"3lwp",
"3lwq",
"3lwr",
"3lwv",
"3mqk",
"3u28",
"3uai",
"7bgb",
"7trc",
"7v9a",
"8oue",
"8ouf",
"9g25",
"9g28",
"9qb2",
"9qb3"
] | 29 | [
"PUB00009858",
"PUB00053435",
"PUB00053436",
"PUB00088317"
] | [
"9843512",
"16647858",
"19917616",
"10871366"
] | [
"Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs.",
"How a single protein complex accommodates many different H/ACA RNAs.",
"The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification.",
"Evolutionary appearance of genes encoding ... | [
1998,
2006,
2009,
2000
] | 4 | [] | [
"IPR023532"
] | 0 | 1 | 0 | [
"Archaea",
"Eukaryota",
"Fervidobacterium pennivorans",
"ecological metagenomes"
] | [
792,
3073,
1,
21
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
7,
1,
1,
3,
4,
1,
1,
7
] | 12 | true | Family | H/ACA ribonucleoprotein complex, subunit Nop10 | H/ACA ribonucleoprotein complex, subunit Nop10 | H/ACA_rnp_Nop10 | 7 |
IPR007265 | 7,265 | Conserved oligomeric Golgi complex, subunit 3 | COG_su3 | Family | 5,398 | false | false | This entry includes Conserved oligomeric Golgi complex subunit 3 (COG3, also known as Sec34), a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking [ ]. COG is a member of the complexes associated with tethering containing helical rods (CATCHR) family which also includes... | [
"GO:0006886",
"GO:0005801",
"GO:0016020"
] | [
"intracellular protein transport",
"cis-Golgi network",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR13302"
] | [
""
] | [
5398
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6807878",
"R-DDI-6811438",
"R-DME-6807878",
"R-DME-6811438",
"R-DME-6811440",
"R-HSA-6807878",
"R-HSA-6811438",
"R-HSA-6811440",
"R-MMU-6807878",
"R-MMU-6811438",
"R-MMU-6811440"
] | [
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-6811438",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811438",
"REACTOME:R-DME-6811440",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-6811438",
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6807878",
"REACTOME:R-MMU-6811438",
"REACTOME:R-MMU-6811440"
] | 11 | [] | 0 | [
"PUB00009854",
"PUB00100047",
"PUB00100048"
] | [
"11703943",
"34061181",
"29335562"
] | [
"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.",
"Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.",
"Cryo-EM structure of the exocyst complex."
] | [
2001,
2021,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5398
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
3,
2,
1,
4,
3,
1,
2,
8,
1,
1,
12
] | 12 | true | Family | Conserved oligomeric Golgi complex, subunit 3 | Conserved oligomeric Golgi complex, subunit 3 | COG_su3 | 8 |
IPR007266 | 7,266 | Endoplasmic reticulum oxidoreductin 1 | Ero1 | Family | 7,110 | false | false | Ero1 and PDI form the disulfide relay system of the ER that supports correct disulfide bond formation of secretory proteins. This entry represents Ero1 (endoplasmic oxidoreductin-1) from yeasts and its homologues from mammals, Ero1-alpha and Ero1-beta. Ero1 is an flavoprotein that directly transfers disulfide bonds to ... | [
"GO:0015035",
"GO:0016972",
"GO:0071949",
"GO:0034975",
"GO:0005783"
] | [
"protein-disulfide reductase activity",
"thiol oxidase activity",
"FAD binding",
"protein folding in endoplasmic reticulum",
"endoplasmic reticulum"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04137",
"PIRSF017205",
"PTHR12613"
] | [
"ERO1",
"ERO1",
""
] | [
7074,
5654,
6987
] | 3 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.8.3.2",
"PWY-7533",
"R-BTA-3299685",
"R-CEL-264876",
"R-DME-264876",
"R-DRE-3299685",
"R-HSA-264876",
"R-HSA-3299685",
"R-MMU-264876",
"R-MMU-3299685",
"R-RNO-3299685",
"R-SSC-3299685",
"R-XTR-3299685"
] | [
"EC:1.8.3.2",
"METACYC:PWY-7533",
"REACTOME:R-BTA-3299685",
"REACTOME:R-CEL-264876",
"REACTOME:R-DME-264876",
"REACTOME:R-DRE-3299685",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-3299685",
"REACTOME:R-MMU-264876",
"REACTOME:R-MMU-3299685",
"REACTOME:R-RNO-3299685",
"REACTOME:R-SSC-3299685",
"R... | 13 | [
"1rp4",
"1rq1",
"3ahq",
"3ahr",
"3m31",
"3nvj"
] | 6 | [
"PUB00009860",
"PUB00009861",
"PUB00068103",
"PUB00068104",
"PUB00097443",
"PUB00097444",
"PUB00097445",
"PUB00097446"
] | [
"10754564",
"10982384",
"22412017",
"18971943",
"22145624",
"25697776",
"22220984",
"32201313"
] | [
"Pathways for protein disulphide bond formation.",
"Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum.",
"Balanced Ero1 activation and inactivation establishes ER redox homeostasis.",
"Low reduction potential of E... | [
2000,
2000,
2012,
2008,
2012,
2015,
2012,
2020
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pectobacterium polaris"
] | [
7109,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
3,
8,
1,
8,
9,
1,
6,
16,
1,
2,
11
] | 12 | true | Family | Endoplasmic reticulum oxidoreductin 1 | Endoplasmic reticulum oxidoreductin 1 | Ero1 | 9 |
IPR007267 | 7,267 | GtrA/DPMS, transmembrane domain | GtrA_DPMS_TM | Domain | 35,143 | false | false | This entry represents a domain found in prokaryotic members of the GtrA family, which are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. GtrA is involved in O antigen modification by Shigella flexneri bacteriophage X... | [
"GO:0000271",
"GO:0016020"
] | [
"polysaccharide biosynthetic process",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04138"
] | [
"GtrA_DPMS_TM"
] | [
35143
] | 1 | [] | [] | [] | 0 | [
"5mlz",
"5mm0",
"5mm1",
"9ep0"
] | 4 | [
"PUB00009862",
"PUB00009863",
"PUB00009864",
"PUB00101943"
] | [
"10376843",
"10358040",
"11029438",
"28743912"
] | [
"Functional analysis of the O antigen glucosylation gene cluster of Shigella flexneri bacteriophage SfX.",
"A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose.",
"A sheep in wolf's clothing: Listeria innocua strains with teichoic acid-associated surfa... | [
1999,
1999,
2000,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
852,
33873,
16,
46,
356
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | GtrA/DPMS, transmembrane domain | GtrA/DPMS, transmembrane domain | GtrA_DPMS_TM | 4 |
IPR007268 | 7,268 | Rad9/Ddc1 | Rad9/Ddc1 | Family | 5,405 | false | false | This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ... | [
"GO:0000077",
"GO:0030896"
] | [
"DNA damage checkpoint signaling",
"checkpoint clamp complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04139",
"PTHR15237"
] | [
"Rad9",
""
] | [
5292,
5296
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-176187",
"R-CEL-5693607",
"R-DME-176187",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"... | [
"REACTOME:R-CEL-176187",
"REACTOME:R-CEL-5693607",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-H... | 25 | [
"3a1j",
"3g65",
"3ggr",
"6j8y",
"7sgz",
"7sh2",
"7st9",
"7stb",
"7z6h",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8",
"8gnn",
"8wu8"
] | 18 | [
"PUB00059229",
"PUB00060228",
"PUB00060720",
"PUB00062256",
"PUB00062275",
"PUB00062277",
"PUB00062279",
"PUB00062280"
] | [
"12604797",
"9311982",
"22034047",
"21978893",
"20005839",
"22925454",
"10713044",
"20729201"
] | [
"Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.",
"The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.",
"Contributions of Rad9 to tumorigenesis.",
"9-1-1: PCNA's specialized cousin.",
"The ... | [
2003,
1997,
2012,
2011,
2009,
2012,
2000,
2010
] | 8 | [] | [
"IPR026217",
"IPR026584"
] | 0 | 2 | 0 | [
"Eukaryota",
"Methanosphaera cuniculi",
"organismal metagenomes"
] | [
5400,
1,
4
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
3,
12,
1,
10,
10,
2,
4,
9,
1,
1,
7
] | 12 | true | Family | Rad9/Ddc1 | Rad9/Ddc1 | Rad9/Ddc1 | 4 |
IPR007269 | 7,269 | Isoprenylcysteine carboxyl methyltransferase | ICMT_MeTrfase | Family | 14,128 | false | false | The isoprenylcysteine o-methyltransferase ( ) carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae, this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine... | [
"GO:0004671",
"GO:0006481",
"GO:0016020"
] | [
"protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity",
"C-terminal protein methylation",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04140"
] | [
"ICMT"
] | [
14128
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.100",
"R-DDI-163841",
"R-HSA-163841",
"R-HSA-9648002",
"R-MMU-163841",
"R-MMU-9648002",
"R-RNO-163841",
"R-RNO-9648002",
"R-SCE-163841",
"R-SPO-163841"
] | [
"EC:2.1.1.100",
"REACTOME:R-DDI-163841",
"REACTOME:R-HSA-163841",
"REACTOME:R-HSA-9648002",
"REACTOME:R-MMU-163841",
"REACTOME:R-MMU-9648002",
"REACTOME:R-RNO-163841",
"REACTOME:R-RNO-9648002",
"REACTOME:R-SCE-163841",
"REACTOME:R-SPO-163841"
] | 10 | [
"4a2n",
"5v7p",
"5vg9"
] | 3 | [
"PUB00009873",
"PUB00065859"
] | [
"11451995",
"22195972"
] | [
"Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family.",
"Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT."
] | [
2001,
2011
] | 2 | [] | [
"IPR025770"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Fadolivirus FV1/VV64",
"unclassified sequences"
] | [
116,
6823,
7067,
1,
121
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
2,
1,
1,
2,
2,
2,
4,
1,
1,
1,
8
] | 12 | true | Family | Isoprenylcysteine carboxyl methyltransferase | Isoprenylcysteine carboxyl methyltransferase | ICMT_MeTrfase | 3 |
IPR007271 | 7,271 | Nucleotide-sugar transporter | Nuc_sug_transpt | Family | 19,693 | false | false | This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles. SLC35A1 ( ) transports CMP-sialic acid, SLC35A2 ( ) transports UDP-galactose and SLC35A3 ( ) transports UDP-GlcNAc [ ]. | [
"GO:0015165",
"GO:0090481",
"GO:0000139",
"GO:0016020"
] | [
"pyrimidine nucleotide-sugar transmembrane transporter activity",
"pyrimidine nucleotide-sugar transmembrane transport",
"Golgi membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04142",
"PIRSF005799",
"PTHR10231"
] | [
"Nuc_sug_transp",
"UDP-gal_transpt",
""
] | [
19401,
11012,
17128
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-727802",
"R-CEL-4085001",
"R-CEL-727802",
"R-CEL-9939291",
"R-CFA-727802",
"R-DRE-9939291",
"R-HSA-4085001",
"R-HSA-5619037",
"R-HSA-5619072",
"R-HSA-5619083",
"R-HSA-5663020",
"R-HSA-727802",
"R-HSA-9939291",
"R-MMU-4085001",
"R-MMU-727802",
"R-MMU-9939291",
"R-RNO-727802",
... | [
"REACTOME:R-BTA-727802",
"REACTOME:R-CEL-4085001",
"REACTOME:R-CEL-727802",
"REACTOME:R-CEL-9939291",
"REACTOME:R-CFA-727802",
"REACTOME:R-DRE-9939291",
"REACTOME:R-HSA-4085001",
"REACTOME:R-HSA-5619037",
"REACTOME:R-HSA-5619072",
"REACTOME:R-HSA-5619083",
"REACTOME:R-HSA-5663020",
"REACTOME:R... | 21 | [
"6i1r",
"6i1z",
"6oh2",
"6oh3",
"6oh4",
"6xbo"
] | 6 | [
"PUB00076708"
] | [
"25210595"
] | [
"Structure and function of nucleotide sugar transporters: Current progress."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
19693
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
17,
15,
14,
3,
48,
25,
2,
13,
21,
2,
63
] | 11 | true | Family | Nucleotide-sugar transporter | Nucleotide-sugar transporter | Nuc_sug_transpt | 1 |
IPR007272 | 7,272 | Sulphur transport TsuA/YedE | Sulf_transp_TsuA/YedE | Family | 23,869 | false | false | This family represents transporter proteins that are primarily involved in the uptake of thiosulfate, a sulfur-containing oxyanion. Members of this family are characterised by their ability to mediate the transport of thiosulfate across the cellular membrane, which is essential for sulfur metabolism in various organism... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04143",
"PTHR30574"
] | [
"Sulf_transp",
""
] | [
21696,
20121
] | 2 | [] | [] | [] | 0 | [
"6leo",
"6lep",
"8j4c",
"8k1r"
] | 4 | [
"PUB00057481",
"PUB00155410"
] | [
"21183667",
"32923628"
] | [
"PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules.",
"Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake."
] | [
2011,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
685,
20804,
2023,
357
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2,
1
] | 2 | true | Family | Sulphur transport TsuA/YedE | Sulphur transport TsuA/YedE | Sulf_transp_TsuA/YedE | 8 |
IPR007273 | 7,273 | SCAMP | SCAMP | Family | 10,899 | false | false | In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain... | [
"GO:0015031",
"GO:0016020"
] | [
"protein transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04144",
"PTHR10687"
] | [
"SCAMP",
""
] | [
10845,
10643
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695",
"R-SSC-6798695"
] | [
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-6798695"
] | 5 | [] | 0 | [
"PUB00009874"
] | [
"11050114"
] | [
"Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10899
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
31,
3,
13,
2,
43,
25,
12,
30,
63
] | 9 | true | Family | SCAMP | SCAMP | SCAMP | 2 |
IPR007274 | 7,274 | Ctr copper transporter | Cop_transporter | Family | 14,868 | false | false | This entry represents the high-affinity copper transporter Ctr1 proteins. The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper tran... | [
"GO:0005375",
"GO:0035434",
"GO:0016020"
] | [
"copper ion transmembrane transporter activity",
"copper ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04145",
"PTHR12483"
] | [
"Ctr",
""
] | [
14806,
14156
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-425410",
"R-MMU-425410",
"R-RNO-425410",
"R-SCE-425410",
"R-SPO-425410",
"R-SSC-425410"
] | [
"REACTOME:R-HSA-425410",
"REACTOME:R-MMU-425410",
"REACTOME:R-RNO-425410",
"REACTOME:R-SCE-425410",
"REACTOME:R-SPO-425410",
"REACTOME:R-SSC-425410"
] | 6 | [
"2ls3",
"6m97",
"6m98"
] | 3 | [
"PUB00019362",
"PUB00093980"
] | [
"11983704",
"11734551"
] | [
"Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake.",
"Biochemical characterization of the human copper transporter Ctr1."
] | [
2002,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Hyphomicrobiales"
] | [
14865,
3
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
19,
15,
4,
8,
6,
7,
4,
19,
6,
3,
3,
20
] | 12 | true | Family | Ctr copper transporter | Ctr copper transporter | Cop_transporter | 2 |
IPR007275 | 7,275 | YTH domain | YTH_domain | Domain | 19,445 | false | false | The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain [ ]. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1. In Saccharomyces cerevisiae, Pho92 is a post... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"CDD"
] | [
"PF04146",
"PS50882",
"cd21134"
] | [
"YTH",
"YTH",
"YTH"
] | [
19183,
19251,
18765
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50882",
"R-DME-9930044",
"R-HSA-9930044",
"R-MMU-9930044",
"R-RNO-9930044"
] | [
"PROSITEDOC:PDOC50882",
"REACTOME:R-DME-9930044",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-9930044",
"REACTOME:R-RNO-9930044"
] | 5 | [
"2mtv",
"2yu6",
"2yud",
"4r3h",
"4r3i",
"4rci",
"4rcj",
"4rcm",
"4rdn",
"4rdo",
"4u8t",
"4wqn",
"5dno",
"5dnp",
"5eim",
"5eip",
"5h8a",
"5hfz",
"5o8m",
"5zuu",
"6fpp",
"6fpq",
"6fpx",
"6k6u",
"6lr2",
"6rt4",
"6rt5",
"6rt6",
"6rt7",
"6syz",
"6sz1",
"6sz2"... | 177 | [
"PUB00045176",
"PUB00077942",
"PUB00077943",
"PUB00077945"
] | [
"16823445",
"24206186",
"26318451",
"25389274"
] | [
"Selective elimination of messenger RNA prevents an incidence of untimely meiosis.",
"A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae.",
"Structural Basis for the Discriminative Recognition of N6-Methylade... | [
2006,
2014,
2015,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
5,
112,
19308,
17,
3
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
107,
10,
2,
18,
14,
1,
48,
19,
1,
1,
160
] | 11 | true | Domain | YTH domain | YTH domain | YTH_domain | 5 |
IPR007276 | 7,276 | Nucleolar protein 14 | Nop14 | Family | 5,263 | false | false | Nucleolar protein 14 (Nop14) is involved in nucleolar processing of pre-18S ribosomal RNA and has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm [ , ]. | [
"GO:0032040"
] | [
"small-subunit processome"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04147",
"PTHR23183"
] | [
"Nop14",
""
] | [
5225,
5197
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 6 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"6zqg",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa"... | 50 | [
"PUB00008496",
"PUB00063036"
] | [
"12068309",
"12446671"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits."
] | [
2002,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5263
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
2,
4,
5,
1,
5,
6,
1,
1,
7
] | 12 | true | Family | Nucleolar protein 14 | Nucleolar protein 14 | Nop14 | 4 |
IPR007277 | 7,277 | Svp26/Tex261 | Svp26/Tex261 | Family | 3,069 | false | false | This entry includes Svp26 from yeasts and Tex261 from animals. Budding yeast Svp26 is a integral membrane protein found in the ER and early Golgi compartment [ ]. It functions as an ER exit adaptor protein of mannosyltransferases Mnt2 and Mnt3 [ ]. The function of Tex261 is not clear. | [
"GO:0097020",
"GO:0006888",
"GO:0016020"
] | [
"COPII receptor activity",
"endoplasmic reticulum to Golgi vesicle-mediated transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04148",
"PTHR13144"
] | [
"Erv26",
""
] | [
3066,
2998
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092553",
"PUB00092554"
] | [
"20236934",
"30700649"
] | [
"Svp26 facilitates endoplasmic reticulum to golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae.",
"Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae."
] | [
2010,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lactobacillales",
"bird metagenome"
] | [
3066,
2,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
8,
1,
1,
6,
1,
1
] | 8 | true | Family | Svp26/Tex261 | Svp26/Tex261 | Svp26/Tex261 | 6 |
IPR007278 | 7,278 | Domain of unknown function DUF397 | DUF397 | Domain | 40,418 | false | false | The function of this family is unknown. It has been suggested that some members of this family are regulators of transcription. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04149"
] | [
"DUF397"
] | [
40418
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Elysia marginata"
] | [
40411,
6,
1
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF397 | Domain of unknown function DUF397 | DUF397 | 5 |
IPR007280 | 7,280 | Peptidase, C-terminal, archaeal/bacterial | Peptidase_C_arc/bac | Domain | 11,010 | false | false | This domain is normally found at the C terminus of secreted archaeal and bacterial peptidases, the majority of which belong to MEROPS peptidase families M4 (vibriolysin, ), M09 (microbial collagenases ColA, ColQ1 and ColT ), M28 (aminopeptidase Ap1, ) and S8 (subtilisin family peptidases, ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04151"
] | [
"PPC"
] | [
11010
] | 1 | [] | [] | [] | 0 | [
"1nqd",
"1nqj",
"1wmd",
"1wme",
"1wmf",
"2luw",
"2o8o",
"3afg",
"3jqw",
"3jqx",
"4dxz",
"4dy3",
"4dy5",
"4dzg",
"4g9s",
"4hpk",
"5fax",
"5fbz",
"5iku",
"5sv5"
] | 20 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
173,
10723,
42,
72
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Peptidase, C-terminal, archaeal/bacterial | Peptidase, C-terminal, archaeal/bacterial | Peptidase_C_arc/bac | 9 |
IPR007281 | 7,281 | Mre11, DNA-binding | Mre11_DNA-bd | Domain | 5,074 | false | false | This entry represents the DNA binding domain of Double-strand break repair protein Mre11 and similar eukaryotic sequences. The MRN complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling, double-strand break (DSB) repair, DNA replication, maintenance ... | [
"GO:0004519",
"GO:0030145",
"GO:0006302",
"GO:0005634"
] | [
"endonuclease activity",
"manganese ion binding",
"double-strand break repair",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"SMART"
] | [
"PF04152",
"SM01347"
] | [
"Mre11_DNA_bind",
"Mre11_DNA_bind"
] | [
5045,
5014
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1834949",
"R-CEL-5685939",
"R-CEL-5693548",
"R-CEL-5693607",
"R-GGA-217106",
"R-GGA-351442",
"R-GGA-351444",
"R-HSA-1834949",
"R-HSA-2559586",
"R-HSA-3270619",
"R-HSA-5685938",
"R-HSA-5685939",
"R-HSA-5685942",
"R-HSA-5693548",
"R-HSA-5693554",
"R-HSA-5693565",
"R-HSA-5693568"... | [
"REACTOME:R-CEL-1834949",
"REACTOME:R-CEL-5685939",
"REACTOME:R-CEL-5693548",
"REACTOME:R-CEL-5693607",
"REACTOME:R-GGA-217106",
"REACTOME:R-GGA-351442",
"REACTOME:R-GGA-351444",
"REACTOME:R-HSA-1834949",
"REACTOME:R-HSA-2559586",
"REACTOME:R-HSA-3270619",
"REACTOME:R-HSA-5685938",
"REACTOME:R... | 67 | [
"3t1i",
"4fbk",
"4fbq",
"4fbw",
"4fcx",
"4yke",
"5da9",
"7zr1",
"8bah",
"9bi4",
"9bi5",
"9q9h",
"9q9i",
"9q9j",
"9q9k",
"9q9m"
] | 16 | [
"PUB00009878",
"PUB00009879",
"PUB00017210",
"PUB00061220",
"PUB00062772",
"PUB00103967",
"PUB00103968"
] | [
"10823903",
"11988766",
"11741547",
"22705791",
"9590181",
"29670289",
"26057807"
] | [
"A mechanistic basis for Mre11-directed DNA joining at microhomologies.",
"The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.",
"Human Rad50/Mre11 is a flexible complex that can tether DNA ends.",
"Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disea... | [
2000,
2002,
2001,
2012,
1998,
2018,
2015
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"candidate division MSBL1"
] | [
5072,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
17,
3,
5,
1,
4,
7,
1,
1,
16
] | 12 | true | Domain | Mre11, DNA-binding | Mre11, DNA-binding | Mre11_DNA-bd | 9 |
IPR007282 | 7,282 | NOT2/NOT3/NOT5, C-terminal | NOT2/3/5_C | Domain | 13,480 | false | false | The Ccr4-Not complex controls mRNA metabolism at multiple levels in eukaryotic cells [ , , ]. This complex is a major cytoplasmic deadenylase consisting of a combination of at least nine subunits, four of which have deadenylase activity [ ]. The conserved core of the CCR4-NOT complex consists of two major modules: a ca... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04153"
] | [
"NOT2_3_5_C"
] | [
13480
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115"
] | [
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115"
] | 5 | [
"4by6",
"4c0d",
"4c0f",
"4c0g",
"5fu6",
"5fu7",
"8k82"
] | 7 | [
"PUB00010587",
"PUB00088275",
"PUB00088276",
"PUB00088277",
"PUB00088315",
"PUB00088316"
] | [
"7926748",
"14707134",
"16712523",
"21299754",
"24121232",
"22027279"
] | [
"NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.",
"Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.",
"Involvement of the SMRT/NCoR-HDAC3 complex in transcript... | [
1994,
2004,
2006,
2011,
2013,
2012
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mycobacterium tuberculosis",
"bird metagenome"
] | [
13478,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
8,
11,
5,
17,
9,
3,
17,
16,
3,
2,
58
] | 12 | true | Domain | NOT2/NOT3/NOT5, C-terminal | NOT2/NOT3/NOT5, C-terminal | NOT2/3/5_C | 9 |
IPR007284 | 7,284 | Ground-like domain | Ground-like_dom | Domain | 2,572 | false | false | This group of proteins contain one or more copies of the ground-like domain, which are specific to Caenorhabditis elegans and Caenorhabditis briggsae. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04155"
] | [
"Ground-like"
] | [
2572
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016650"
] | [
"10523520"
] | [
"Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
2572
] | 1 | [
"Caenorhabditis elegans"
] | [
55
] | 1 | true | Domain | Ground-like domain | Ground-like domain | Ground-like_dom | 2 |
IPR007287 | 7,287 | Sof1-like protein | Sof1 | Domain | 4,498 | false | false | Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04158"
] | [
"Sof1"
] | [
4498
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6791226",
"R-DDI-8951664",
"R-DRE-8951664",
"R-HSA-6790901",
"R-HSA-6791226",
"R-HSA-8951664",
"R-MMU-6791226",
"R-MMU-8951664",
"R-SCE-6791226",
"R-SPO-6791226",
"R-SPO-8951664",
"R-XTR-8951664"
] | [
"REACTOME:R-DDI-6791226",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DRE-8951664",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-6791226",
"REACTOME:R-MMU-8951664",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226",
"REACTOME:R-SPO-8951664",
"REACTOM... | 12 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 41 | [
"PUB00009882"
] | [
"8508778"
] | [
"A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4498
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
3,
2,
1,
1,
2,
3,
1,
1,
4
] | 12 | true | Domain | Sof1-like protein | Sof1-like protein | Sof1 | 1 |
IPR007288 | 7,288 | Influenzavirus B, glycoprotein NB | InfluenzaB_glycoprotein_NB | Family | 11,251 | false | false | The NB glycoprotein is found in Influenza type B virus. It forms putative viral proton channel and may play a role in virus entry [ ]. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04159"
] | [
"NB"
] | [
11251
] | 1 | [
"GP"
] | [
"GenProp1013"
] | [
"GP:GenProp1013"
] | 1 | [] | 0 | [
"PUB00066816"
] | [
"15042345"
] | [
"An amino-acid substitution in the influenza-B NB protein affects ion-channel gating."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Influenza B virus"
] | [
11251
] | 1 | [] | [] | 0 | true | Family | Influenzavirus B, glycoprotein NB | Influenzavirus B, glycoprotein NB | InfluenzaB_glycoprotein_NB | 9 |
IPR007289 | 7,289 | Jaagsiekte sheep retrovirus, Vpu | JSRV_Vpu | Family | 39 | false | false | This short protein has no known function and is found in Jaagsiekte sheep retrovirus. Jaagsiekte sheep retrovirus (JSRV) is the etiological agent of a contagious lung tumour of sheep known as sheep pulmonary adenomatosis. JSRV exhibits a simple genetic organisation, characteristic of the type D and type B retroviruses,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04160"
] | [
"Borrelia_orfX"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010092"
] | [
"10653922"
] | [
"An accessory open reading frame (orf-x) of jaagsiekte sheep retrovirus is conserved between different virus isolates."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Ortervirales",
"Ovis aries"
] | [
20,
19
] | 2 | [] | [] | 0 | true | Family | Jaagsiekte sheep retrovirus, Vpu | Jaagsiekte sheep retrovirus, Vpu | JSRV_Vpu | 3 |
IPR007290 | 7,290 | Arv1 protein | Arv1 | Family | 4,308 | false | false | Arv1 is a transmembrane protein, with potential zinc-binding motifs, that mediates sterol homeostasis. Its action is important in lipid homeostasis, which prevents free sterol toxicity [ ]. Arv1 contains a homology domain (AHD), which consists of an N-terminal cysteine-rich subdomain with a putative zinc-binding motif,... | [
"GO:0032366"
] | [
"intracellular sterol transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04161",
"PTHR14467"
] | [
"Arv1",
""
] | [
4305,
4131
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-191273",
"R-HSA-191273",
"R-MMU-191273",
"R-SCE-191273",
"R-SPO-191273"
] | [
"REACTOME:R-DDI-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-MMU-191273",
"REACTOME:R-SCE-191273",
"REACTOME:R-SPO-191273"
] | 5 | [] | 0 | [
"PUB00009883",
"PUB00043518",
"PUB00043519",
"PUB00043520"
] | [
"11063737",
"16725371",
"18287539",
"12145310"
] | [
"Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1.",
"Arabidopsis thaliana expresses two functional isoforms of Arvp, a protein involved in the regulation of cellular lipid homeostasis.",
"Yeast ARV1 is required for efficient delivery of an early GPI intermediat... | [
2000,
2006,
2008,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4308
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
1,
1,
4,
5,
4,
1,
4,
2,
1,
1,
11
] | 12 | true | Family | Arv1 protein | Arv1 protein | Arv1 | 6 |
IPR007291 | 7,291 | Capsid protein | Capsid_protein | Family | 1,055 | false | false | Capsid protein (CA1, also known as VP1) self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. It is essential for the initial attachment to host... | [
"GO:0019028"
] | [
"viral capsid"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04162"
] | [
"Gyro_capsid"
] | [
1055
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062399"
] | [
"9880024"
] | [
"Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Shotokuvirae"
] | [
1055
] | 1 | [] | [] | 0 | true | Family | Capsid protein | Capsid protein | Capsid_protein | 1 |
IPR007292 | 7,292 | Nuclear fusion protein Kar5 | Nuclear_fusion_Kar5 | Family | 1,477 | false | false | Nuclear fusion protein KAR5 is an integral membrane protein that is thought to be required for the fusion of nuclear envelopes during karyogamy [ ]. | [
"GO:0000742",
"GO:0048288"
] | [
"karyogamy involved in conjugation with cellular fusion",
"nuclear membrane fusion involved in karyogamy"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04163",
"PTHR28012"
] | [
"Tht1",
""
] | [
887,
1452
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091080"
] | [
"10069807"
] | [
"Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomadura fulvescens",
"Eukaryota"
] | [
1,
1476
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Nuclear fusion protein Kar5 | Nuclear fusion protein Kar5 | Nuclear_fusion_Kar5 | 3 |
IPR007293 | 7,293 | Flagellar protein FlgP | FlgP | Family | 924 | false | false | This family includes FlgP from Vibrio cholerae, which is part of an operon with two genes, flgO and flgP, positively regulated by FlrC, the activator of class III flagellar genes. FlgP is an outer membrane lipoprotein required for motility that functions as a colonization factor [ , , ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF028687"
] | [
"UCP028687"
] | [
924
] | 1 | [] | [] | [] | 0 | [
"8z5n",
"8z60",
"9hmf"
] | 3 | [
"PUB00078827",
"PUB00078828",
"PUB00094404"
] | [
"17981980",
"19592588",
"30559113"
] | [
"Lipidation of an FlrC-dependent protein is required for enhanced intestinal colonization by Vibrio cholerae.",
"Characterization of two outer membrane proteins, FlgO and FlgP, that influence vibrio cholerae motility.",
"Characterization of FlgP, an Essential Protein for Flagellar Assembly in Rhodobacter sphaer... | [
2008,
2009,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
919,
5
] | 2 | [] | [] | 0 | true | Family | Flagellar protein FlgP | Flagellar protein FlgP | FlgP | 8 |
IPR007294 | 7,294 | Protein of unknown function DUF401 | DUF401 | Family | 591 | false | false | Members of this family are predicted to have 10 transmembrane regions. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04165",
"PTHR39556"
] | [
"DUF401",
""
] | [
587,
578
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR005253"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
100,
427,
8,
56
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF401 | Protein of unknown function DUF401 | DUF401 | 6 |
IPR007295 | 7,295 | Domain of unknown function DUF402 | DUF402 | Domain | 10,534 | false | false | This β-barrel domain is found in Cytidylyl-2-hydroxypropylphosphonate hydrolase from Streptomyces wedmorensis (FomD), a protein encoded in the fosfomycin biosynthesis gene cluster [ , ]. This domain is also found in Ntdp (nucleoside tri- and diphosphatase, also known as Sa1684) from Staphylococcus aureus [ ] and relate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04167"
] | [
"DUF402"
] | [
10534
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.15",
"3.6.1.6",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:3.6.1.15",
"EC:3.6.1.6",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 7 | [
"2p12",
"3cbt",
"3exm",
"5zdm",
"5zdn",
"7d8g",
"7d8i",
"7d8l",
"7d8q",
"8rza",
"8rzf",
"8wo8"
] | 12 | [
"PUB00009885",
"PUB00100530",
"PUB00100531"
] | [
"7500951",
"30010320",
"33955674"
] | [
"Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.",
"Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl ( S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis.",
"The structural mechanism for the nucleoside tri- and diphosphate... | [
1995,
2018,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
550,
9949,
3,
32
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF402 | Domain of unknown function DUF402 | DUF402 | 6 |
IPR007298 | 7,298 | NlpE-like, N-terminal domain | NlpE-like_N | Domain | 4,584 | false | false | This entry represents the N-terminal domain in NlpE proteins. This domain also covers the whole length in the 17 kDa lipoprotein from Treponema pallidum. Lipoprotein NlpE is a multifunctional outer membrane lipoprotein implicated in copper homeostasis, potentially contributing to both copper efflux and the delivery of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04170"
] | [
"NlpE"
] | [
4584
] | 1 | [] | [] | [] | 0 | [
"2z4h",
"2z4i",
"3lhn",
"4u3q"
] | 4 | [
"PUB00009886",
"PUB00010108",
"PUB00050195",
"PUB00159866",
"PUB00163368"
] | [
"7635807",
"11830644",
"17698001",
"15252048",
"7635808"
] | [
"Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli.",
"Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway.",
"Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli.",
"Effects of lipoprot... | [
1995,
2002,
2007,
2004,
1995
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Myoviridae sp. cta6i12",
"Trichuris trichiura",
"unclassified sequences"
] | [
4561,
1,
1,
21
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | NlpE-like, N-terminal domain | NlpE-like, N-terminal domain | NlpE-like_N | 1 |
IPR007301 | 7,301 | TQO small subunit DoxD | DoxD | Domain | 1,404 | false | false | is a subunit of the terminal quinol oxidase present in the plasma membrane of Acidianus ambivalens, with calculated molecular mass of 20.4kDa [ ]. Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation. A novel TQO enzyme was purified from the thermo-acidophilic archaeon A. a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04173"
] | [
"DoxD"
] | [
1404
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015233"
] | [
"15306018"
] | [
"Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
174,
1164,
66
] | 3 | [] | [] | 0 | true | Domain | TQO small subunit DoxD | TQO small subunit DoxD | DoxD | 1 |
IPR007302 | 7,302 | Circularly permuted ATPgrasp domain | CP_ATPgrasp | Domain | 696 | false | false | This ATP-grasp domain is present both as catalytically active and inactive versions. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system that additionally contains a transglutaminase, an NTN-hydrolase, the Alpha-E domain, and a transglutaminase fused N-terminal to a circul... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04174"
] | [
"CP_ATPgrasp_1"
] | [
696
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057486"
] | [
"20023723"
] | [
"Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
682,
7,
7
] | 3 | [] | [] | 0 | true | Domain | Circularly permuted ATPgrasp domain | Circularly permuted ATPgrasp domain | CP_ATPgrasp | 5 |
IPR007303 | 7,303 | TIP41-like protein | TIP41-like | Family | 4,688 | false | false | In budding yeast, TIP41 interacts with TAP42 to regulate protein phosphatase activity [ ]. In mammalian cells, TIP41-like protein (TIPRL) does not directly bind TAP42, but rather primarily interacts with PP2A, PP4 or PP6 catalytic subunits. TIPRL inhibits PP4 activity to allow for H2AX phosphorylation and the subsequen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04176"
] | [
"TIP41"
] | [
4688
] | 1 | [] | [] | [] | 0 | [
"5d9g",
"5w0w",
"5w0x"
] | 3 | [
"PUB00009890",
"PUB00092555"
] | [
"11741537",
"26717153"
] | [
"TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.",
"TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response."
] | [
2001,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4688
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
1,
1,
2,
1,
2,
6,
1,
1,
9
] | 12 | true | Family | TIP41-like protein | TIP41-like protein | TIP41-like | 1 |
IPR007304 | 7,304 | TAP46-like protein | TAP46-like | Family | 4,655 | false | false | This entry represents a family of proteins involved in the regulation of phosphatases. It includes TAP46 and TAP42, as well as others. TAP46 is involved in the positive regulation of the TOR signaling pathway in plants, acting as a negative regulator of PP2A catalytic activity [ ]. The TOR signalling pathway activates ... | [
"GO:0009966"
] | [
"regulation of signal transduction"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04177",
"PTHR10933"
] | [
"TAP42",
""
] | [
4650,
4557
] | 2 | [] | [] | [] | 0 | [
"2v0p",
"3qc1",
"4iyp"
] | 3 | [
"PUB00009889",
"PUB00009890",
"PUB00088253"
] | [
"10604478",
"11741537",
"21216945"
] | [
"The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.",
"TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.",
"The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants."
] | [
1999,
2001,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4655
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S... | [
5,
1,
1,
2,
3,
1,
7,
4,
1,
1,
12
] | 11 | true | Family | TAP46-like protein | TAP46-like protein | TAP46-like | 4 |
IPR007305 | 7,305 | Vesicle transport protein, Got1/SFT2-like | Vesicle_transpt_Got1/SFT2 | Family | 15,302 | false | false | Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events [ ]. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like prote... | [
"GO:0016192"
] | [
"vesicle-mediated transport"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04178"
] | [
"Got1"
] | [
15302
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009891",
"PUB00015208"
] | [
"10406798",
"7596416"
] | [
"Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex.",
"A SNARE-like protein required for traffic through the Golgi complex."
] | [
1999,
1995
] | 2 | [] | [
"IPR011691",
"IPR045176"
] | 0 | 2 | 0 | [
"Eukaryota",
"Halobacillus litoralis",
"Klosneuvirinae",
"metagenomes"
] | [
15294,
1,
4,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
32,
6,
9,
9,
7,
8,
2,
23,
19,
2,
2,
42
] | 12 | true | Family | Vesicle transport protein, Got1/SFT2-like | Vesicle transport protein, Got1/SFT2-like | Vesicle_transpt_Got1/SFT2 | 1 |
IPR007306 | 7,306 | tRNA A64-2'-O-ribosylphosphate transferase | Rit1 | Family | 2,761 | false | false | This entry includes tRNA A64-2'-O-ribosylphosphate transferase Rit1 from budding yeasts. Rit1 is a phospho-ribosyl transferase that exclusively modifies the initiator tRNA (tRNAMet(i)) by the addition of a 2'-O-ribosyl phosphate group to Adenosine 64 [ , ]. This entry also includes the C3F10.06c protein from Schizosacc... | [
"GO:0043399",
"GO:0019988"
] | [
"tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity",
"charged-tRNA amino acid modification"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF007747",
"PTHR31811"
] | [
"Ribosyl_Ptfrase",
""
] | [
1879,
2761
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009892",
"PUB00073576"
] | [
"7954819",
"10485288"
] | [
"Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.",
"Genetic interactions between a null allele of the RIT1 gene encoding an initiator tRNA-specific modification enzyme and genes encoding translation factors in Saccharomyces cerevisiae."
] | [
1994,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2761
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
1,
3,
1,
1,
8
] | 6 | true | Family | tRNA A64-2'-O-ribosylphosphate transferase | tRNA A64-2'-O-ribosylphosphate transferase | Rit1 | 3 |
IPR007307 | 7,307 | Low temperature viability protein Ltv1 | Ltv1 | Family | 4,818 | false | false | The low-temperature viability protein Ltv1 is required for 40S subunit biogenesis in yeast [ ]. It may facilitate the incorporation of Rps3, Rps10, and Asc1/RACK1 into the small ribosomal subunit head [ ]. | [
"GO:0042274"
] | [
"ribosomal small subunit biogenesis"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04180",
"PTHR21531"
] | [
"LTV",
""
] | [
3826,
4700
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6791226",
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226"
] | [
"REACTOME:R-BTA-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226"
] | 4 | [
"5wwo",
"6fai",
"6g18",
"6g4s",
"6g51",
"6g53",
"6y7c",
"7wtt",
"7wtu",
"7wtw",
"7wtx",
"7wtz",
"7wu0",
"8cbj",
"8zdc",
"8zdd"
] | 16 | [
"PUB00092557",
"PUB00092558"
] | [
"16888326",
"30348748"
] | [
"Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae.",
"Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head."
] | [
2006,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4818
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
3,
1,
3,
1,
1,
7,
3,
1,
1,
16
] | 12 | true | Family | Low temperature viability protein Ltv1 | Low temperature viability protein Ltv1 | Ltv1 | 1 |
IPR007308 | 7,308 | Rtr1/RPAP2 domain | Rtr1/RPAP2_dom | Domain | 4,062 | false | false | This entry represents a domain found in RPAP2 (RNAP II associated polypeptide) protein and the yeast Rtr1 proteins. It has been suggested that this family of proteins are regulators of core RNA polymerase II function [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF04181",
"PS51479"
] | [
"RPAP2_Rtr1",
"ZF_RTR1"
] | [
3922,
4059
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.16",
"R-CEL-6807505",
"R-DRE-6807505",
"R-HSA-6807505",
"R-MMU-6807505",
"R-RNO-6807505",
"R-SCE-6807505"
] | [
"EC:3.1.3.16",
"REACTOME:R-CEL-6807505",
"REACTOME:R-DRE-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505",
"REACTOME:R-RNO-6807505",
"REACTOME:R-SCE-6807505"
] | 7 | [
"4fc8",
"4m3o",
"5c2y",
"7b7u",
"7f4g"
] | 5 | [
"PUB00045120"
] | [
"18408053"
] | [
"Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3,
4057,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
3,
1,
2,
1,
1,
15,
2,
1,
10
] | 12 | true | Domain | Rtr1/RPAP2 domain | Rtr1/RPAP2 domain | Rtr1/RPAP2_dom | 7 |
IPR007309 | 7,309 | B-block binding subunit of TFIIIC | TFIIIC_Bblock-bd | Domain | 4,682 | false | false | Yeast transcription factor IIIC (TFIIIC) is a multisubunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding [ ]. Although defined as a yeast protein, it is also found in a number of oth... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04182"
] | [
"B-block_TFIIIC"
] | [
4682
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-749476",
"R-HSA-76061",
"R-HSA-76066",
"R-MMU-76061",
"R-MMU-76066",
"R-RNO-76061",
"R-RNO-76066",
"R-SCE-76066",
"R-SPO-76061",
"R-SPO-76066"
] | [
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76061",
"REACTOME:R-HSA-76066",
"REACTOME:R-MMU-76061",
"REACTOME:R-MMU-76066",
"REACTOME:R-RNO-76061",
"REACTOME:R-RNO-76066",
"REACTOME:R-SCE-76066",
"REACTOME:R-SPO-76061",
"REACTOME:R-SPO-76066"
] | 10 | [
"8cli",
"8clj",
"8clk",
"8cll",
"8ffz",
"9gc3",
"9gck"
] | 7 | [
"PUB00009893"
] | [
"1279682"
] | [
"TFC3: gene encoding the B-block binding subunit of the yeast transcription factor IIIC."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
178,
13,
4488,
3
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
18,
3,
1,
3,
9,
1,
11,
9,
1,
1,
30
] | 11 | true | Domain | B-block binding subunit of TFIIIC | B-block binding subunit of TFIIIC | TFIIIC_Bblock-bd | 2 |
IPR007310 | 7,310 | Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal | Aerobactin_biosyn_IucA/IucC_N | Domain | 14,062 | false | false | Bacteria solve the iron supply problem caused by the insolubility of Fe(3) by synthesizing iron-complexing compounds, called siderophores, and by using iron sources of their hosts, such as haem and iron bound to transferrin and lactoferrin. Escherichia coli, as an example of a Gram-negative bacterium, forms sophisticat... | [
"GO:0019290"
] | [
"siderophore biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04183"
] | [
"IucA_IucC"
] | [
14062
] | 1 | [
"GP"
] | [
"GenProp1593"
] | [
"GP:GenProp1593"
] | 1 | [
"2w02",
"2w03",
"2w04",
"2x0o",
"2x0p",
"2x0q",
"2x3j",
"2x3k",
"3ffe",
"3to3",
"5jm7",
"5jm8",
"5o7o",
"6cn7",
"6nl2",
"6p63",
"6xrc",
"7cbb",
"7tgj",
"7tgk",
"7tgl",
"7tgm",
"7tgn",
"9nom"
] | 24 | [
"PUB00009894",
"PUB00092857",
"PUB00154502",
"PUB00154503"
] | [
"3087960",
"19775248",
"18956041",
"36702957"
] | [
"Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli.",
"Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.",
"Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy... | [
1986,
2009,
2008,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
13102,
691,
249,
20
] | 4 | [] | [] | 0 | true | Domain | Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal | Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal | Aerobactin_biosyn_IucA/IucC_N | 9 |
IPR007311 | 7,311 | ST7 | ST7 | Family | 5,562 | false | false | The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene [ ]. It localises to the cytoplasm and plasma membrane and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure [ ]. The molecular function of this prot... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF04184",
"PTHR12745",
"cd11557"
] | [
"ST7",
"",
"ST7"
] | [
5561,
5418,
4826
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092559",
"PUB00098159"
] | [
"16474848",
"20238225"
] | [
"ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix.",
"Localization and characterization of ST7 in cancer."
] | [
2006,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanoculleus",
"ecological metagenomes"
] | [
161,
5393,
4,
4
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
2,
31,
10,
22
] | 6 | true | Family | ST7 | ST7 | ST7 | 1 |
IPR007312 | 7,312 | Phosphoesterase | Phosphoesterase | Family | 23,141 | false | false | This entry includes both bacterial phospholipase C enzymes ( ) and eukaryotic acid phosphatases ( ). | [
"GO:0016788"
] | [
"hydrolase activity, acting on ester bonds"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04185",
"PTHR31956"
] | [
"Phosphoesterase",
""
] | [
23026,
21597
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"3.1.4.3",
"PWY-7782",
"PWY-7783",
"PWY-8052",
"R-HSA-9636383",
"R-HSA-9636569"
] | [
"EC:3.1.4.3",
"METACYC:PWY-7782",
"METACYC:PWY-7783",
"METACYC:PWY-8052",
"REACTOME:R-HSA-9636383",
"REACTOME:R-HSA-9636569"
] | 6 | [
"2d1g",
"8hav",
"8haw",
"8k3g",
"8yk5",
"9gy2",
"9gye"
] | 7 | [] | [] | [] | [] | 0 | [] | [
"IPR017767",
"IPR017768"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
99,
15299,
7623,
5,
115
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
1,
18,
18
] | 4 | true | Family | Phosphoesterase | Phosphoesterase | Phosphoesterase | 7 |
IPR007313 | 7,313 | FxsA cytoplasmic membrane protein | FxsA | Family | 11,690 | false | false | This is a bacterial family of cytoplasmic membrane proteins. It includes two transmembrane regions. The molecular function of FxsA is unknown, but in Escherichia coli its overexpression has been shown to alleviate the exclusion of phage T7 in those cells with an F plasmid. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM",
"PFAM",
"PANTHER"
] | [
"NF008528",
"PF04186",
"PTHR35335"
] | [
"PRK11463.1-2",
"FxsA",
""
] | [
11620,
11665,
11443
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019587"
] | [
"10497017"
] | [
"Increased synthesis of an Escherichia coli membrane protein suppresses F exclusion of bacteriophage T7."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
368,
11080,
11,
231
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | FxsA cytoplasmic membrane protein | FxsA cytoplasmic membrane protein | FxsA | 2 |
IPR007314 | 7,314 | Haem-binding uptake, Tiki superfamily, ChaN | Cofac_haem-bd_dom | Domain | 6,177 | false | false | This entry represents a domain found in ChaN family members. ChaN is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron. The structure of , , comprises a large parallel β-sheet with flanking α-helices and a smaller domain consisting of α-helices. Two cofacial haem groups bind in a pocket ... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF04187",
"cd14727"
] | [
"Cofac_haem_bdg",
"ChanN-like"
] | [
6177,
5487
] | 2 | [] | [] | [] | 0 | [
"2g5g"
] | 1 | [
"PUB00040938",
"PUB00075535",
"PUB00075716"
] | [
"16950397",
"23868957",
"23596191"
] | [
"Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.",
"Tiki, at the head of a new superfamily of enzymes.",
"Functional Redundancy and Divergence within the Arabidopsis RETICULATA-RELATED Gene Family."
] | [
2006,
2013,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5012,
1094,
71
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
5,
11
] | 3 | true | Domain | Haem-binding uptake, Tiki superfamily, ChaN | Haem-binding uptake, Tiki superfamily, ChaN | Cofac_haem-bd_dom | 6 |
IPR007315 | 7,315 | GPI mannosyltransferase 2 | PIG-V/Gpi18 | Family | 9,838 | false | false | This entry represents GPI mannosyltransferase 2, also known as PIG-V in humans or Gpi18 in fungi. PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol (GPI) biosynthesis [ , , ]. GPI is a glycolipid that anchors many proteins to the eukaryotic cell surface [ ]. | [
"GO:0000009",
"GO:0004376",
"GO:0006506"
] | [
"alpha-1,6-mannosyltransferase activity",
"GPI mannosyltransferase activity",
"GPI anchor biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF04188",
"PTHR12468"
] | [
"Mannosyl_trans2",
""
] | [
6164,
9711
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 207 | [] | 0 | [
"PUB00019834",
"PUB00019835",
"PUB00044430"
] | [
"15623507",
"15720390",
"17615295"
] | [
"PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol.",
"Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly.",
"Pga1 is an essential component of Glycosylphosphatidylinosito... | [
2005,
2005,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
9,
5120,
4626,
83
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
1,
1,
12,
1,
1,
3,
4,
1,
1,
14
] | 12 | true | Family | GPI mannosyltransferase 2 | GPI mannosyltransferase 2 | PIG-V/Gpi18 | 8 |
IPR007317 | 7,317 | Golgi to ER traffic protein 4 | GET4 | Family | 4,738 | false | false | In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [ , ]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the end... | [
"GO:0045048"
] | [
"protein insertion into ER membrane"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04190",
"PTHR12875"
] | [
"GET4",
""
] | [
4708,
4649
] | 2 | [
"REACTOME"
] | [
"R-HSA-9609523"
] | [
"REACTOME:R-HSA-9609523"
] | 1 | [
"2wpv",
"3lku",
"3lpz",
"4pwx",
"5bw8",
"5bwk",
"6au8",
"7ru9",
"7rua",
"7ruc",
"9ns5"
] | 11 | [
"PUB00086005",
"PUB00086007",
"PUB00086008",
"PUB00092560",
"PUB00092561",
"PUB00092562",
"PUB00092563"
] | [
"21636303",
"21743475",
"28104892",
"20676083",
"22190685",
"24727835",
"25535373"
] | [
"A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.",
"Protein targeting and degradation are coupled for elimination of mislocalized proteins.",
"Mechanistic basis for a molecular triage reaction.",
"A ribosome-associating factor chaperones tai... | [
2011,
2011,
2017,
2010,
2012,
2014,
2015
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4738
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
2,
4,
3,
1,
3,
3,
1,
1,
17
] | 12 | true | Family | Golgi to ER traffic protein 4 | Golgi to ER traffic protein 4 | GET4 | 9 |
IPR007318 | 7,318 | Phospholipid methyltransferase | Phopholipid_MeTrfase | Domain | 20,315 | false | false | This entry includes Saccharomyces cerevisiae phospholipid methyltransferase , which has a broad substrate specificity of unsaturated phospholipids [ ], and related enzymes such as methanethiol S-methyltransferase ( ), which catalyses the methylation of methanethiol to yield dimethylsulphide (a volatile compound importa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04191"
] | [
"PEMT"
] | [
20315
] | 1 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.17",
"GenProp1516",
"PWY-6825",
"R-BTA-1483191",
"R-DDI-1483191",
"R-HSA-1483191",
"R-MMU-1483191",
"R-RNO-1483191",
"R-SCE-1483191",
"R-SPO-1483191"
] | [
"EC:2.1.1.17",
"GP:GenProp1516",
"METACYC:PWY-6825",
"REACTOME:R-BTA-1483191",
"REACTOME:R-DDI-1483191",
"REACTOME:R-HSA-1483191",
"REACTOME:R-MMU-1483191",
"REACTOME:R-RNO-1483191",
"REACTOME:R-SCE-1483191",
"REACTOME:R-SPO-1483191"
] | 10 | [
"8xku",
"8xkv"
] | 2 | [
"PUB00009897",
"PUB00089624"
] | [
"2445736",
"25807229"
] | [
"Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes.",
"A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments."
] | [
1987,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
341,
12953,
6624,
397
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
12,
7,
3,
3,
2,
3,
8,
2,
2,
2
] | 10 | true | Domain | Phospholipid methyltransferase | Phospholipid methyltransferase | Phopholipid_MeTrfase | 8 |
IPR007319 | 7,319 | WDR36/Utp21, C-terminal domain | WDR36/Utp21_C | Domain | 4,766 | false | false | Utp21 is a component of the SSU processome, which is required for pre-18S rRNA processing. It interacts with Utp18 [ ]. Utp21 from yeast and WDR36 its orthologue in animals are part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit. They are involved in the nucleolar p... | [
"GO:0006364",
"GO:0032040"
] | [
"rRNA processing",
"small-subunit processome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04192"
] | [
"Utp21"
] | [
4766
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 4 | [
"5ica",
"5jpq",
"5oql",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t"... | 50 | [
"PUB00008496",
"PUB00035836",
"PUB00035837",
"PUB00090524",
"PUB00151110"
] | [
"12068309",
"15590835",
"15489292",
"21051332",
"34516797"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"The small-subunit processome is a ribosome assembly intermediate.",
"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.",
"Lack of WDR36 leads to preimplantation embryoni... | [
2002,
2004,
2004,
2011,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4766
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
2,
1,
5,
1,
3,
7,
1,
1,
15
] | 12 | true | Domain | WDR36/Utp21, C-terminal domain | WDR36/Utp21, C-terminal domain | WDR36/Utp21_C | 3 |
IPR007320 | 7,320 | Programmed cell death protein 2, C-terminal | PDCD2_C | Domain | 6,967 | false | false | PDCD2 is localized predominantly in the cytosol of cells situated at the opposite pole of the germinal centre from the centroblasts as well as in cells in the mantle zone. It is a chaperone for ribosomal protein uS5. It cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the... | [
"GO:0005737"
] | [
"cytoplasm"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04194"
] | [
"PDCD2_C"
] | [
6967
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00163284",
"PUB00163285"
] | [
"27697862",
"33245768"
] | [
"Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.",
"PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)."
] | [
2016,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6967
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
7,
5,
4,
3,
1,
8,
4,
1,
2,
25
] | 12 | true | Domain | Programmed cell death protein 2, C-terminal | Programmed cell death protein 2, C-terminal | PDCD2_C | 3 |
IPR007321 | 7,321 | Transposase (putative), gypsy type | Transposase_28 | Domain | 11,895 | false | false | This domain is found in a family of plant gene products and is thought to be related to gypsy type transposons. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04195"
] | [
"Transposase_28"
] | [
11895
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Inquilinus limosus",
"Mesangiospermae"
] | [
1,
11894
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
613,
27
] | 3 | true | Domain | Transposase (putative), gypsy type | Transposase (putative), gypsy type | Transposase_28 | 6 |
IPR007322 | 7,322 | RNA-dependent RNA polymerase, bunyaviral | RNA_pol_bunyavir | Domain | 5,857 | false | false | The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encoded by the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment. | [
"GO:0003968",
"GO:0006351",
"GO:0019079"
] | [
"RNA-directed RNA polymerase activity",
"DNA-templated transcription",
"viral genome replication"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04196"
] | [
"Bunya_RdRp"
] | [
5857
] | 1 | [
"EC",
"GP"
] | [
"2.7.7.48",
"GenProp1007"
] | [
"EC:2.7.7.48",
"GP:GenProp1007"
] | 2 | [
"5amq",
"5amr",
"6l42",
"6y6k",
"6z6b",
"6z6g",
"6z8k",
"7alp",
"7eei",
"7ori",
"7orj",
"7ork",
"7orl",
"7orm",
"7orn",
"7oro",
"8as6",
"8as7",
"8asb",
"8asd",
"8asg",
"8c4s",
"8c4t",
"8c4u",
"8c4v",
"8ci5",
"8ki6",
"8ki7",
"8ki8",
"8ki9",
"8kia",
"8p1j"... | 46 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Viruses"
] | [
22,
5835
] | 2 | [] | [] | 0 | true | Domain | RNA-dependent RNA polymerase, bunyaviral | RNA-dependent RNA polymerase, bunyaviral | RNA_pol_bunyavir | 5 |
IPR007324 | 7,324 | Sugar-binding domain, putative | Sugar-bd_dom_put | Domain | 19,121 | false | false | This probable domain is found in bacterial transcriptional regulators such as DeoR, SorC and CggR. One of these proteins, , has an N-terminal helix-turn-helix that binds to DNA. This domain is probably the ligand regulator binding region. SorC is regulated by sorbose and other members of this family are likely to be re... | [
"GO:0030246"
] | [
"carbohydrate binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04198"
] | [
"Sugar-bind"
] | [
19121
] | 1 | [] | [] | [] | 0 | [
"2gnp",
"2o0m",
"2okg",
"2r5f",
"2w48",
"3bxe",
"3bxf",
"3bxg",
"3bxh",
"3efb",
"3kv1",
"3nze",
"4go1",
"4l4y",
"4l4z",
"4l50",
"4l51",
"4l5i",
"4l5j",
"4oqp",
"4oqq",
"4r9n",
"8r3g",
"8r7y"
] | 24 | [
"PUB00057833",
"PUB00067928"
] | [
"12622823",
"10714997"
] | [
"Regulation of the central glycolytic genes in Bacillus subtilis: binding of the repressor CggR to its single DNA target sequence is modulated by fructose-1,6-bisphosphate.",
"Purification and characterization of the DeoR repressor of Bacillus subtilis."
] | [
2003,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
18995,
12,
114
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Sugar-binding domain, putative | Sugar-binding domain, putative | Sugar-bd_dom_put | 3 |
IPR007325 | 7,325 | Kynurenine formamidase/cyclase-like | KFase/CYL | Family | 32,140 | false | false | Kynurenine formamidase catalyses the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation [ ]. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form a part of the active site. This family also includes cyclase-like proteins from pla... | [
"GO:0004061",
"GO:0019441"
] | [
"arylformamidase activity",
"L-tryptophan catabolic process to L-kynurenine"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04199",
"PTHR31118"
] | [
"Cyclase",
""
] | [
31977,
16684
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.5.1.9",
"PWY-5651",
"PWY-6309",
"PWY-7717",
"PWY-7733",
"PWY-7734",
"PWY-7765"
] | [
"EC:3.5.1.9",
"METACYC:PWY-5651",
"METACYC:PWY-6309",
"METACYC:PWY-7717",
"METACYC:PWY-7733",
"METACYC:PWY-7734",
"METACYC:PWY-7765"
] | 7 | [
"1r61",
"2b0a",
"3krv",
"4co9",
"4cob",
"4cog",
"4cz1",
"4j0n",
"4m8d",
"5ibz",
"5nmp",
"5nna",
"5nnb",
"8f9x",
"8hmo"
] | 15 | [
"PUB00043036",
"PUB00088719",
"PUB00090512"
] | [
"14592712",
"25974367",
"24917679"
] | [
"Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase.",
"Characterization of a novel cyclase-like gene family involved in controlling stress tolerance in rice.",
"A proton wire and water channel revealed in the crystal structure of isatin hydrolase."
] | [
2003,
2015,
2014
] | 3 | [] | [
"IPR017484"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
997,
22375,
8290,
478
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
1,
7,
27
] | 4 | true | Family | Kynurenine formamidase/cyclase-like | Kynurenine formamidase/cyclase-like | KFase/CYL | 9 |
IPR007326 | 7,326 | Lipoprotein-associated domain | Lipoprotein-assoc_dom | Domain | 501 | false | false | This presumed domain is about 100 amino acids in length. It is found in lipoproteins of unknown function. The domain is found in up to five copies in some proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04200"
] | [
"Lipoprotein_17"
] | [
501
] | 1 | [] | [] | [] | 0 | [
"2krt",
"3jvc",
"3k63"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Elysia marginata"
] | [
500,
1
] | 2 | [] | [] | 0 | true | Domain | Lipoprotein-associated domain | Lipoprotein-associated domain | Lipoprotein-assoc_dom | 1 |
IPR007327 | 7,327 | Tumour protein D52 | TPD52 | Family | 7,834 | false | false | The hD52 gene was originally identified through its elevated expression level in human breast carcinoma [ ]. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been iden... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04201",
"PTHR19307"
] | [
"TPD52",
""
] | [
7805,
7771
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-432722",
"R-GGA-432722",
"R-HSA-432722",
"R-MMU-432722"
] | [
"REACTOME:R-CEL-432722",
"REACTOME:R-GGA-432722",
"REACTOME:R-HSA-432722",
"REACTOME:R-MMU-432722"
] | 4 | [] | 0 | [
"PUB00009900",
"PUB00152873"
] | [
"9484778",
"15555543"
] | [
"Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.",
"The tumor protein D52 family: many pieces, many puzzles."
] | [
1998,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
7834
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
41,
12,
21,
21,
32
] | 6 | true | Family | Tumour protein D52 | Tumour protein D52 | TPD52 | 3 |
IPR007328 | 7,328 | Foot protein 3 | Mfp-3 | Family | 74 | false | false | Mytilus foot protein-3 (Mfp-3) is a highly polymorphic protein family located in the byssal adhesive plaques of blue mussels [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04202"
] | [
"Mfp-3"
] | [
74
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019856"
] | [
"8706704"
] | [
"Cloning, sequencing and sites of expression of genes for the hydroxyarginine-containing adhesive-plaque protein of the mussel Mytilus galloprovincialis."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Protostomia",
"Pseudomonadati"
] | [
69,
5
] | 2 | [] | [] | 0 | true | Family | Foot protein 3 | Foot protein 3 | Mfp-3 | 3 |
IPR007329 | 7,329 | FMN-binding | FMN-bd | Domain | 25,128 | false | false | This conserved region includes the FMN-binding site of the NqrC protein [ ] as well as the NosR and NirI regulatory proteins. This domain is post-translationally flavinylated and may facilitate electron transfer, resembling multiheme cytochromes [ ]. It is also found in NADH:(hydroxy)cinnamate reductase subunit CrdB th... | [
"GO:0010181",
"GO:0016020"
] | [
"FMN binding",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF04205",
"SM00900"
] | [
"FMN_bind",
"FMN_bind"
] | [
24543,
24485
] | 2 | [] | [] | [] | 0 | [
"2kzx",
"3dcz",
"3lwx",
"3o6u",
"4u9s",
"4xa7",
"4xhf",
"7xk3",
"7xk4",
"7xk5",
"7xk6",
"7xk7",
"7zc6",
"8a1t",
"8a1u",
"8a1v",
"8a1w",
"8a1x",
"8a1y",
"8acw",
"8acy",
"8ad0",
"8ahx",
"8evu",
"8ew3",
"8p2a",
"8p2b",
"8rb8",
"8rb9",
"8rbm",
"8rbq",
"9eri"... | 48 | [
"PUB00010090",
"PUB00098250",
"PUB00154570"
] | [
"11248234",
"34032212",
"38622093"
] | [
"Expression and mutagenesis of the NqrC subunit of the NQR respiratory Na(+) pump from Vibrio cholerae with covalently attached FMN.",
"Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life.",
"A Redox-Regulated, Heterodimeric NADH:cinnamate R... | [
2001,
2021,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
52,
24512,
24,
539,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | FMN-binding | FMN-binding | FMN-bd | 8 |
IPR007330 | 7,330 | MIT domain | MIT_dom | Domain | 21,472 | false | false | The MIT domain forms an asymmetric three-helix bundle. It is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. A 'variant' MIT domain has been described at the N-termin... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF04212",
"SM00745"
] | [
"MIT",
"MIT"
] | [
16936,
19312
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-917729",
"R-BTA-9668328",
"R-DDI-917729",
"R-DDI-9668328",
"R-DME-9668328",
"R-DRE-9668328",
"R-GGA-9668328",
"R-HSA-1474228",
"R-HSA-162588",
"R-HSA-5632684",
"R-HSA-917729",
"R-HSA-9610379",
"R-HSA-9668328",
"R-MMU-1474228",
"R-MMU-5632684",
"R-MMU-917729",
"R-MMU-9668328",
... | [
"REACTOME:R-BTA-917729",
"REACTOME:R-BTA-9668328",
"REACTOME:R-DDI-917729",
"REACTOME:R-DDI-9668328",
"REACTOME:R-DME-9668328",
"REACTOME:R-DRE-9668328",
"REACTOME:R-GGA-9668328",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-162588",
"REACTOME:R-HSA-5632684",
"REACTOME:R-HSA-917729",
"REACTOME:R-... | 26 | [
"1wfd",
"1wr0",
"1yxr",
"2cpt",
"2dl1",
"2jq9",
"2jqh",
"2jqk",
"2k3w",
"2mpk",
"2v6x",
"2v6y",
"2w2u",
"2ymb",
"2zam",
"2zan",
"2zao",
"3eab",
"4a5x",
"4lcb",
"4niq",
"4u7i",
"4u7y",
"4wzx",
"5fvk",
"5fvl",
"5uie",
"5xmi",
"5xmk",
"6p07",
"6pek",
"6pen"... | 36 | [
"PUB00069769"
] | [
"20339000"
] | [
"A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization."
] | [
2010
] | 1 | [] | [
"IPR045253",
"IPR045331"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
165,
2,
21281,
24
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
4,
25,
15,
60,
25,
2,
9,
44,
1,
1,
27
] | 12 | true | Domain | MIT domain | MIT domain | MIT_dom | 7 |
IPR007331 | 7,331 | Htaa | Htaa | Domain | 2,269 | false | false | This domain is found in HtaA, a secreted protein implicated in iron acquisition and transport [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04213"
] | [
"HtaA"
] | [
2269
] | 1 | [] | [] | [] | 0 | [
"6js9",
"6jsa",
"6jsb",
"6jsc",
"6jsd",
"8smu",
"9o0j",
"9o0k"
] | 8 | [
"PUB00009904"
] | [
"10760164"
] | [
"Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
2264,
5
] | 2 | [] | [] | 0 | true | Domain | Htaa | Htaa | Htaa | 9 |
IPR007332 | 7,332 | Protein of unknown function DUF411 | DUF411 | Family | 7,076 | false | false | The function of the members of this bacterial protein family is unknown. Some members may be involved in conferring cation resistance. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04214"
] | [
"DUF411"
] | [
7076
] | 1 | [] | [] | [] | 0 | [
"6wis",
"6wje"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
100,
6873,
11,
92
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF411 | Protein of unknown function DUF411 | DUF411 | 5 |
IPR007334 | 7,334 | Uncharacterised protein family UPF0208 | UPF0208 | Family | 2,113 | false | false | This family consists of bacterial uncharacterised proteins. | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM",
"PFAM"
] | [
"MF_01101",
"NF002493",
"PF04217"
] | [
"UPF0208",
"PRK01816.1",
"DUF412"
] | [
1424,
2086,
2113
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104115"
] | [
"22532809"
] | [
"Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eumetazoa",
"metagenomes"
] | [
2107,
2,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Uncharacterised protein family UPF0208 | Uncharacterised protein family UPF0208 | UPF0208 | 4 |
IPR007335 | 7,335 | Protein of unknown function DUF413 | DUF413 | Family | 2,178 | false | false | This is a family of uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04219"
] | [
"DUF413"
] | [
2178
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Trichuris trichiura",
"ecological metagenomes"
] | [
2168,
1,
9
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF413 | Protein of unknown function DUF413 | DUF413 | 7 |
IPR007336 | 7,336 | Der GTPase-activating protein YihI | YihI | Family | 2,277 | false | false | This entry represents Der GTPase-activating protein YihI from Escherichia coli (strain K12) and similar proteins predominantly found in Gammaproteobacteria. YihI is a GTPase activating protein (GAP) that modifies the activity of Der, a 50S ribosomal subunit stability factor. The stimulation is specific to Der as YihI d... | [
"GO:0005096"
] | [
"GTPase activator activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM",
"PFAM"
] | [
"MF_01058",
"NF003560",
"PF04220"
] | [
"GAP_YihI",
"PRK05244.1-1",
"YihI"
] | [
2105,
2220,
2277
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053968"
] | [
"20434458"
] | [
"A bacterial GAP-like protein, YihI, regulating the GTPase of Der, an essential GTP-binding protein in Escherichia coli."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
2271,
3,
3
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Der GTPase-activating protein YihI | Der GTPase-activating protein YihI | YihI | 2 |
IPR007337 | 7,337 | RelB antitoxin/Antitoxin DinJ | RelB/DinJ | Family | 9,818 | false | false | Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF04221",
"PTHR38781",
"TIGR02384"
] | [
"RelB",
"",
"RelB_DinJ"
] | [
9791,
6923,
8166
] | 3 | [
"GP",
"GP",
"GP"
] | [
"GenProp0321",
"GenProp0324",
"GenProp1193"
] | [
"GP:GenProp0321",
"GP:GenProp0324",
"GP:GenProp1193"
] | 3 | [
"2k29",
"2kc8",
"4fxe",
"4ml0",
"4q2u",
"9lew"
] | 6 | [
"PUB00009906",
"PUB00009907",
"PUB00057354",
"PUB00060311",
"PUB00060312",
"PUB00064223",
"PUB00095315"
] | [
"11274135",
"12123459",
"17263853",
"19210620",
"19707553",
"22981948",
"24923448"
] | [
"Purification of the RelB and RelE proteins of Escherichia coli: RelE binds to RelB and to ribosomes.",
"Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins.",
"Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module.",
"Bacterial toxin YafQ is... | [
2001,
2002,
2007,
2009,
2009,
2012,
2014
] | 7 | [] | [
"IPR026262"
] | 0 | 1 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriati",
"Sym plasmid",
"unclassified sequences"
] | [
9674,
7,
10,
5,
1,
121
] | 6 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | RelB antitoxin/Antitoxin DinJ | RelB antitoxin/Antitoxin DinJ | RelB/DinJ | 7 |
IPR007338 | 7,338 | Protein of unknown function DUF416 | DUF416 | Family | 2,671 | false | false | This is a bacterial family of uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04222"
] | [
"DUF416"
] | [
2671
] | 1 | [] | [] | [] | 0 | [
"2q9r",
"3f7c"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2660,
6,
5
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF416 | Protein of unknown function DUF416 | DUF416 | 1 |
IPR007339 | 7,339 | Inner membrane protein RclC-like | RclC-like | Family | 3,545 | false | false | This family of uncharacterised proteins appears to be restricted to proteobacteria. It includes inner membrane protein RclC (YkgD) from Escherichia coli , which is a reactive chlorine-specific transcription factor [ ]. These proteins are related to the DoxX family . Members of this family form a confident homodimeric s... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04224",
"PTHR40106"
] | [
"DUF417",
""
] | [
3545,
3416
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00085116"
] | [
"24078635"
] | [
"The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli."
] | [
2013
] | 1 | [] | [
"IPR016865"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3537,
4,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Inner membrane protein RclC-like | Inner membrane protein RclC-like | RclC-like | 9 |
IPR007340 | 7,340 | Opacity-associated protein A, LysM-like domain | LysM_Opacity-associatedA | Domain | 5,021 | false | false | The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A [ ]. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colo... | [
"GO:0042834"
] | [
"peptidoglycan binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF04225"
] | [
"LysM_OapA"
] | [
5021
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.24.-",
"PWY-8119"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119"
] | 2 | [
"2gu1",
"6u2a",
"6ue4"
] | 3 | [
"PUB00020973",
"PUB00094178",
"PUB00094179",
"PUB00160317",
"PUB00160318"
] | [
"8559074",
"29686141",
"23565292",
"23834664",
"30782657"
] | [
"Identification and characterization of a cell envelope protein of Haemophilus influenzae contributing to phase variation in colony opacity and nasopharyngeal colonization.",
"YtfB, an OapA Domain-Containing Protein, Is a New Cell Division Protein in Escherichia coli.",
"Harnessing single cell sorting to identi... | [
1995,
2018,
2013,
2013,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
4983,
4,
34
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Opacity-associated protein A, LysM-like domain | Opacity-associated protein A, LysM-like domain | LysM_Opacity-associatedA | 7 |
IPR007342 | 7,342 | Pseudouridine-5'-phosphate glycosidase | PsuG | Family | 10,530 | false | false | Members of this entry catalyse the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil [ ]. It is also reported to be involved in the synthesis of indigoidine, which is a blue pigment synthesised by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA... | [
"GO:0004730"
] | [
"pseudouridylate synthase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PFAM"
] | [
"MF_01876",
"PF04227"
] | [
"PsiMP_glycosidase",
"Indigoidine_A"
] | [
8876,
10530
] | 2 | [
"EC",
"METACYC"
] | [
"4.2.1.70",
"PWY-6019"
] | [
"EC:4.2.1.70",
"METACYC:PWY-6019"
] | 2 | [
"1vkm",
"4ex8",
"4ex9",
"4gij",
"4gik",
"4gil",
"4gim",
"8k05",
"8k06",
"8k07"
] | 10 | [
"PUB00009588",
"PUB00064226"
] | [
"11790734",
"23066817"
] | [
"Characterization of indigoidine biosynthetic genes in Erwinia chrysanthemi and role of this blue pigment in pathogenicity.",
"Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."
] | [
2002,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanocrinis alkalitolerans",
"Eukaryota",
"metagenomes"
] | [
6054,
1,
4270,
205
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
5,
1,
2,
2,
1,
1,
5,
1,
11
] | 9 | true | Family | Pseudouridine-5'-phosphate glycosidase | Pseudouridine-5'-phosphate glycosidase | PsuG | 1 |
IPR007343 | 7,343 | Uncharacterised protein family, zinc metallopeptidase putative | Uncharacterised_pept_Zn_put | Family | 15,161 | false | false | Members of this family of bacterial proteins are described as hypothetical proteins or zinc metallopeptidases. The majority have a HExxH zinc-binding motif characteristic of neutral zinc metallopeptidases, however there is no evidence to support their function as metallopeptidases. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04228",
"PTHR30168"
] | [
"Zn_peptidase",
""
] | [
15145,
14562
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Rhodococcus phage Weasels2",
"unclassified sequences"
] | [
3,
15081,
12,
1,
64
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Uncharacterised protein family, zinc metallopeptidase putative | Uncharacterised protein family, zinc metallopeptidase putative | Uncharacterised_pept_Zn_put | 8 |
IPR007345 | 7,345 | Polysaccharide pyruvyl transferase | Polysacch_pyruvyl_Trfase | Domain | 20,695 | false | false | Pyruvyl-transferases are involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04230"
] | [
"PS_pyruv_trans"
] | [
20695
] | 1 | [] | [] | [] | 0 | [
"5ax7",
"6x1l"
] | 2 | [
"PUB00005717",
"PUB00009913"
] | [
"8118055",
"10970841"
] | [
"Analysis of the Rhizobium meliloti genes exoU, exoV, exoW, exoT, and exoI involved in exopolysaccharide biosynthesis and nodule invasion: exoU and exoW probably encode glucosyltransferases.",
"Bacterial SLH domain proteins are non-covalently anchored to the cell surface via a conserved mechanism involving wall p... | [
1993,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
223,
19677,
498,
35,
262
] | 5 | [
"Escherichia coli (strain K12)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Polysaccharide pyruvyl transferase | Polysaccharide pyruvyl transferase | Polysacch_pyruvyl_Trfase | 3 |
IPR007346 | 7,346 | Endonuclease I | Endonuclease-I | Family | 9,975 | false | false | Bacterial periplasmic or secreted ( ) Escherichia coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species. It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it gen... | [
"GO:0004518"
] | [
"nuclease activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04231",
"PTHR33607"
] | [
"Endonuclease_1",
""
] | [
9954,
9688
] | 2 | [
"EC"
] | [
"3.1.21"
] | [
"EC:3.1.21"
] | 1 | [
"1ouo",
"1oup",
"2g7e",
"2g7f",
"2ivk",
"2pu3",
"2vnd"
] | 7 | [
"PUB00009914",
"PUB00009915",
"PUB00009916"
] | [
"7867949",
"3036665",
"1396690"
] | [
"The periplasmic endonuclease I of Escherichia coli has amino-acid sequence homology to the extracellular DNases of Vibrio cholerae and Aeromonas hydrophila.",
"Extracellular proteins of Vibrio cholerae: molecular cloning, nucleotide sequence and characterization of the deoxyribonuclease (DNase) together with its... | [
1995,
1987,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group I thaumarchaeote",
"Viruses",
"unclassified sequences"
] | [
9236,
619,
1,
10,
109
] | 5 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
1,
6
] | 2 | true | Family | Endonuclease I | Endonuclease I | Endonuclease-I | 8 |
IPR007347 | 7,347 | Sporulation stage V, protein S | SpoVS | Family | 3,201 | false | false | In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG. SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation. Null mutations in the spoVS gene block sporulation at stage V, impairing the development ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04232",
"PTHR35331"
] | [
"SpoVS",
""
] | [
3188,
3041
] | 2 | [] | [] | [] | 0 | [
"2eh1",
"2ek0"
] | 2 | [
"PUB00009917"
] | [
"7559352"
] | [
"Identification and characterization of sporulation gene spoVS from Bacillus subtilis."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
2833,
23,
313,
32
] | 4 | [] | [] | 0 | true | Family | Sporulation stage V, protein S | Sporulation stage V, protein S | SpoVS | 2 |
IPR007348 | 7,348 | CopC domain | CopC_dom | Domain | 15,044 | false | false | Copper resistance protein C (CopC) is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm [ ]. The structure of CopC consists of a Greek key β-barrel fold [ ]. | [
"GO:0005507",
"GO:0046688",
"GO:0042597"
] | [
"copper ion binding",
"response to copper ion",
"periplasmic space"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04234"
] | [
"CopC"
] | [
15044
] | 1 | [] | [] | [] | 0 | [
"1ix2",
"1lyq",
"1m42",
"1nm4",
"1ot4",
"2c9p",
"2c9q",
"2c9r",
"5icu",
"5n1t",
"6nfq",
"6nfr",
"6nfs",
"6tpb",
"7bk5",
"7bk6",
"7bk7",
"8ytq",
"8ytr",
"9c14"
] | 20 | [
"PUB00009918",
"PUB00022139"
] | [
"1924351",
"12377120"
] | [
"Copper resistance in Pseudomonas syringae mediated by periplasmic and outer membrane proteins.",
"Solution structure of CopC: a cupredoxin-like protein involved in copper homeostasis."
] | [
1991,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
119,
14539,
12,
374
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | CopC domain | CopC domain | CopC_dom | 5 |
IPR007349 | 7,349 | Domain of unknown function DUF418 | DUF418 | Domain | 14,151 | false | false | This domain of unknown function is found in probable integral membrane proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04235"
] | [
"DUF418"
] | [
14151
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
121,
13910,
27,
93
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF418 | Domain of unknown function DUF418 | DUF418 | 3 |
IPR007350 | 7,350 | Transposase, Tc5, C-terminal | Transposase_Tc5_C | Domain | 336 | false | false | This domain corresponds to a C-terminal cysteine rich region that probably binds to a metal ion and could be DNA-binding. It is found in association with the DDE superfamily domain ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04236"
] | [
"Transp_Tc5_C"
] | [
336
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Nitrosocosmicus franklandianus",
"Pandoravirus celtis",
"Protostomia"
] | [
1,
1,
334
] | 3 | [
"Caenorhabditis elegans"
] | [
2
] | 1 | true | Domain | Transposase, Tc5, C-terminal | Transposase, Tc5, C-terminal | Transposase_Tc5_C | 5 |
IPR007351 | 7,351 | YjbR | YjbR | Family | 13,418 | false | false | YjbR is predicted to contain the DNA binding domain comprising the 'double wing' motif [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35145"
] | [
""
] | [
13418
] | 1 | [] | [] | [] | 0 | [
"2a1v",
"2fki",
"2kfp",
"3h9x"
] | 4 | [
"PUB00040706"
] | [
"17266124"
] | [
"NMR structure of protein yjbR from Escherichia coli reveals 'double-wing' DNA binding motif."
] | [
2007
] | 1 | [
"IPR058532"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
13303,
4,
11,
100
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | YjbR | YjbR | YjbR | 5 |
IPR007352 | 7,352 | Protein of unknown function DUF420 | DUF420 | Family | 5,035 | false | false | This is a predicted membrane protein with four transmembrane helices. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04238",
"PTHR37692"
] | [
"DUF420",
""
] | [
5034,
4839
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
660,
4295,
3,
77
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF420 | Protein of unknown function DUF420 | DUF420 | 8 |
IPR007353 | 7,353 | YetF, C-terminal domain | DUF421 | Domain | 19,153 | false | false | This domain is found at the C-terminal end of the YetF protein, which contains three N-terminal transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04239"
] | [
"DUF421"
] | [
19153
] | 1 | [] | [] | [] | 0 | [
"3c6f"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
47,
18948,
68,
90
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Domain | YetF, C-terminal domain | YetF, C-terminal domain | DUF421 | 1 |
IPR007354 | 7,354 | Bisanhydrobacterioruberin hydratase CruF-like | CruF-like | Family | 3,471 | false | false | This family consists of bacterial and archaeal proteins. The representative member is CruF, a C50 carotenoid 2',3'-hydratase involved in the synthesis of the C50 carotenoid bacterioruberin in the halophilic archaeon Haloarcula japonica [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04240",
"PTHR39419"
] | [
"Caroten_synth",
""
] | [
3470,
3344
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00077981"
] | [
"25712483"
] | [
"Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica."
] | [
2015
] | 1 | [] | [
"IPR017823",
"IPR054684"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
465,
2826,
17,
163
] | 4 | [] | [] | 0 | true | Family | Bisanhydrobacterioruberin hydratase CruF-like | Bisanhydrobacterioruberin hydratase CruF-like | CruF-like | 7 |
IPR007355 | 7,355 | Protein of unknown function DUF424 | DUF424 | Family | 896 | false | false | Members of this family of uncharacterised proteins are found in archaea and viruses including Uncharacterized 14.4 kDa protein and 14,6 kDa from virus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04242"
] | [
"DUF424"
] | [
896
] | 1 | [] | [] | [] | 0 | [
"2qya"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphabaculovirus",
"Archaea",
"unclassified sequences"
] | [
87,
778,
31
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF424 | Protein of unknown function DUF424 | DUF424 | 5 |
IPR007356 | 7,356 | tRNA (guanine(9)-N1)-methyltransferase, eukaryotic | tRNA_m1G_MeTrfase_euk | Family | 8,369 | false | false | Transfer RNA molecules contain numerous modified nucleosides, particularly within the anticodon region, which are introduced by various tRNA-modifying enzymes prior to the formation of mature tRNA. Among these modifications, N1-methylguanine (m1G) at position 37 is catalysed by tRNA (guanine-N1)-methyltransferase , whi... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF27710",
"PTHR13563"
] | [
"TRM10_TRM10A",
""
] | [
8291,
8002
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1",
"2.1.1.221",
"R-HSA-6782315",
"R-HSA-6785470",
"R-HSA-6787450",
"R-HSA-8868766"
] | [
"EC:2.1.1",
"EC:2.1.1.221",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6785470",
"REACTOME:R-HSA-6787450",
"REACTOME:R-HSA-8868766"
] | 6 | [
"4fmw",
"4jwf",
"4jwg",
"4jwh",
"4jwj",
"5nfj",
"6ems",
"6emt",
"6emu",
"6emv",
"7onu",
"8cbk",
"8cbl",
"8cbm",
"8cbo",
"8rr1",
"8rr3",
"8rr4",
"9ey0",
"9ey1",
"9ey2",
"9gch"
] | 22 | [
"PUB00006251",
"PUB00006289",
"PUB00006365",
"PUB00058128",
"PUB00058129",
"PUB00088046"
] | [
"2207153",
"7689113",
"9047363",
"12702816",
"15640439",
"25053765"
] | [
"Role of tRNA modification in translational fidelity.",
"Deficiency of 1-methylguanosine in tRNA from Salmonella typhimurium induces frameshifting by quadruplet translocation.",
"Structural requirements for the formation of 1-methylguanosine in vivo in tRNA(Pro)GGG of Salmonella typhimurium.",
"Identification... | [
1990,
1993,
1997,
2003,
2005,
2014
] | 6 | [] | [
"IPR016653"
] | 0 | 1 | 0 | [
"Archaea",
"Desulfurobacterium",
"Eukaryota",
"uncultured organism MedDCM-OCT-S04-C12"
] | [
54,
2,
8312,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
4,
5,
2,
9,
8,
1,
5,
11,
1,
1,
10
] | 12 | true | Family | tRNA (guanine(9)-N1)-methyltransferase, eukaryotic | tRNA (guanine(9)-N1)-methyltransferase, eukaryotic | tRNA_m1G_MeTrfase_euk | 1 |
IPR007357 | 7,357 | Photolyase PhrB-like | PhrB-like | Family | 6,434 | false | false | This entry includes PhrB from Agrobacterium fabrum and related proteins. PhrB is a photolyase involved in the repair of UV-induced (6-4) lesions in DNA. It catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04244"
] | [
"DPRP"
] | [
6434
] | 1 | [] | [] | [] | 0 | [
"3zxs",
"4dja",
"5kcm",
"5lfa",
"6dd6",
"7ykn",
"8a1h",
"8ijy",
"9hnk",
"9hnl",
"9hnm",
"9hnn",
"9hno",
"9q8f"
] | 14 | [
"PUB00067229"
] | [
"23589886"
] | [
"Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Imitervirales",
"unclassified sequences"
] | [
230,
5995,
22,
30,
157
] | 5 | [] | [] | 0 | true | Family | Photolyase PhrB-like | Photolyase PhrB-like | PhrB-like | 6 |
IPR007358 | 7,358 | Nucleoid-associated protein NdpA | Nucleoid_associated_NdpA | Family | 8,422 | false | false | The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I revealed significant amounts of two proteins not previously detected in wild-type E. coli. Partial amino-terminal sequencing has identified them as... | [
"GO:0009295"
] | [
"nucleoid"
] | [
"cellular_component"
] | 1 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PANTHER"
] | [
"MF_00730",
"NF001557",
"PF04245",
"PTHR38772"
] | [
"NdpA",
"PRK00378.1",
"NA37",
""
] | [
2554,
3338,
8419,
4445
] | 4 | [] | [] | [] | 0 | [
"9be2"
] | 1 | [
"PUB00010123"
] | [
"10368163"
] | [
"Identification of two new proteins in spermidine nucleoids isolated from Escherichia coli."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
8337,
24,
8,
6,
47
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Nucleoid-associated protein NdpA | Nucleoid-associated protein NdpA | Nucleoid_associated_NdpA | 3 |
IPR007359 | 7,359 | Positive regulator of sigma(E), RseC/MucC | SigmaE_reg_RseC_MucC | Family | 4,746 | false | false | This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cell... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35867"
] | [
""
] | [
4746
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009919",
"PUB00009920"
] | [
"9159522",
"9335303"
] | [
"Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins.",
"Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium."
] | [
1997,
1997
] | 2 | [
"IPR059252"
] | [
"IPR026268"
] | 1 | 1 | 0 | [
"Bacteria",
"Neoptera",
"unclassified sequences"
] | [
4637,
2,
107
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Positive regulator of sigma(E), RseC/MucC | Positive regulator of sigma(E), RseC/MucC | SigmaE_reg_RseC_MucC | 9 |
IPR007360 | 7,360 | Invasion gene expression up-regulator, SirB | SirB | Family | 3,755 | false | false | SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04247",
"PIRSF005610",
"PTHR39594"
] | [
"SirB",
"SirB",
""
] | [
3748,
3501,
3439
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009921"
] | [
"10322010"
] | [
"A HilA-independent pathway to Salmonella typhimurium invasion gene transcription."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"unclassified sequences"
] | [
3716,
3,
36
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Invasion gene expression up-regulator, SirB | Invasion gene expression up-regulator, SirB | SirB | 7 |
IPR007361 | 7,361 | Domain of unknown function DUF427 | DUF427 | Domain | 13,764 | false | false | This domain consists of 10 β-strands and 2 short α-helices forming a β-tent fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04248"
] | [
"NTP_transf_9"
] | [
13764
] | 1 | [] | [] | [] | 0 | [
"3djm"
] | 1 | [
"PUB00078711"
] | [
"25569776"
] | [
"The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
62,
11244,
2368,
90
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF427 | Domain of unknown function DUF427 | DUF427 | 6 |
IPR007362 | 7,362 | Protein of unknown function DUF429 | DUF429 | Family | 3,983 | false | false | This family of prokaryotic uncharacterised proteins are predicted to show an RNase H fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04250"
] | [
"DUF429"
] | [
3983
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR008306",
"IPR018036"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Ustilaginomycotina",
"unclassified sequences"
] | [
393,
3515,
3,
72
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF429 | Protein of unknown function DUF429 | DUF429 | 9 |
IPR007365 | 7,365 | Transferrin receptor-like, dimerisation domain | TFR-like_dimer_dom | Domain | 12,069 | false | false | This entry represents the dimerisation domain found in the transferrin receptor, as well as in a number of other proteins including glutamate carboxypeptidase II and N-acetylated-alpha-linked acidic dipeptidase like protein. The transferrin receptor (TfR) assists iron uptake into vertebrate cells through a cycle of end... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04253"
] | [
"TFR_dimer"
] | [
12069
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-432722",
"R-CEL-8963693",
"R-CEL-8980692",
"R-CEL-9013026",
"R-CEL-9013149",
"R-CEL-9013404",
"R-CEL-9013406",
"R-CEL-9013407",
"R-CEL-9013408",
"R-CEL-9013423",
"R-HSA-432722",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8963693",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106... | [
"REACTOME:R-CEL-432722",
"REACTOME:R-CEL-8963693",
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013404",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013407",
"REACTOME:R-CEL-9013408",
"REACTOME:R-CEL-9013423",
"REACTOME:R-HSA-432722",
"REACTOME:... | 89 | [
"1cx8",
"1de4",
"1suv",
"1z8l",
"2c6c",
"2c6g",
"2c6p",
"2cij",
"2jbj",
"2jbk",
"2nsu",
"2oot",
"2or4",
"2pvv",
"2pvw",
"2xef",
"2xeg",
"2xei",
"2xej",
"3bhx",
"3bi0",
"3bi1",
"3bxm",
"3d7d",
"3d7f",
"3d7g",
"3d7h",
"3fec",
"3fed",
"3fee",
"3ff3",
"3iww"... | 112 | [
"PUB00015088"
] | [
"10531064"
] | [
"Crystal structure of the ectodomain of human transferrin receptor."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
611,
11441,
17
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
8,
3,
9,
22,
11,
2,
15,
18,
3,
1,
29
] | 11 | true | Domain | Transferrin receptor-like, dimerisation domain | Transferrin receptor-like, dimerisation domain | TFR-like_dimer_dom | 8 |
IPR007366 | 7,366 | Protein of unknown function DUF432 | DUF432 | Family | 676 | false | false | Proteins in this entry are functionally uncharacterised, found in bacteria and archaea. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF04254",
"PIRSF019202"
] | [
"DUF432",
"UCP019202"
] | [
676,
193
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
249,
419,
3,
5
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF432 | Protein of unknown function DUF432 | DUF432 | 9 |
IPR007367 | 7,367 | VapB45-like, C-terminal | VapB45_C | Domain | 9,929 | false | false | This entry (ex DUF433) includes a group of uncharacterised proteins, including VapB45 from Mycobacterium tuberculosis. VapB45 is possibly the antitoxin component of a type II toxin-antitoxin (TA) module. Its cognate toxin is VapC45 [ ]. This entry also includes AF_0609 (Archaeoglobus fulgidus), y4eO (Sinorhizobium fred... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04255"
] | [
"DUF433"
] | [
9929
] | 1 | [] | [] | [] | 0 | [
"2ga1",
"5af3"
] | 2 | [
"PUB00077551"
] | [
"24662523"
] | [
"Multiple toxin-antitoxin systems in Mycobacterium tuberculosis."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
448,
9281,
6,
10,
184
] | 5 | [] | [] | 0 | true | Domain | VapB45-like, C-terminal | VapB45-like, C-terminal | VapB45_C | 4 |
IPR007368 | 7,368 | Domain of unknown function DUF434 | DUF434 | Domain | 732 | false | false | The function of DUF434 is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04256"
] | [
"DUF434"
] | [
732
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Tanacetum cinerariifolium",
"ecological metagenomes"
] | [
260,
458,
1,
13
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF434 | Domain of unknown function DUF434 | DUF434 | 3 |
IPR007369 | 7,369 | Peptidase A22B, signal peptide peptidase | Peptidase_A22B_SPP | Family | 15,719 | false | false | This group of sequences contain aspartic endopeptidases that belong to MEROPS peptidase family A22 (presenilin family), subfamily A22B. These are intramembrane cleaving proteases (I-CLiPs). They are also known as signal peptide peptidases (SPPs) [ ]. SPP cleaves remnant signal peptides left behind in the membrane by th... | [
"GO:0042500",
"GO:0016020"
] | [
"aspartic endopeptidase activity, intramembrane cleaving",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04258",
"PTHR12174"
] | [
"Peptidase_A22B",
""
] | [
15535,
15365
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.23.-",
"R-HSA-5357905",
"R-HSA-9707587",
"R-MMU-5357905",
"R-MMU-9707587",
"R-RNO-5357905"
] | [
"EC:3.4.23.-",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-9707587",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-9707587",
"REACTOME:R-RNO-5357905"
] | 6 | [
"9k92",
"9k93"
] | 2 | [
"PUB00000093",
"PUB00000349",
"PUB00000522",
"PUB00001330",
"PUB00011023",
"PUB00011707",
"PUB00021296",
"PUB00035898",
"PUB00035899",
"PUB00035900",
"PUB00042504",
"PUB00065205",
"PUB00066803",
"PUB00076784",
"PUB00076785",
"PUB00076786"
] | [
"2194475",
"1851433",
"8439290",
"6795036",
"10331925",
"11566868",
"10864493",
"14741365",
"12966028",
"17517891",
"2682266",
"23254940",
"21765428",
"4912600",
"10497172",
"21751400"
] | [
"The structure and function of the aspartic proteinases.",
"Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.",
"Evolutionary families of peptidases.",
"Gastric proteinases--structure, function, evolution and mechanism of action.",
"Crystal structure of the hy... | [
1990,
1991,
1993,
1981,
1999,
2001,
2000,
2004,
2003,
2007,
1989,
2013,
2011,
1970,
1999,
2011
] | 16 | [
"IPR006639"
] | [] | 1 | 0 | 1 | [
"Bacteria candidate phyla",
"Eukaryota",
"Megaviridae environmental sample",
"Methanosarcinaceae"
] | [
5,
15702,
1,
11
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
34,
7,
17,
6,
30,
19,
1,
14,
26,
1,
1,
60
] | 12 | true | Family | Peptidase A22B, signal peptide peptidase | Peptidase A22B, signal peptide peptidase | Peptidase_A22B_SPP | 7 |
IPR007370 | 7,370 | Glutamate--cysteine ligase | Glu_cys_ligase | Domain | 7,766 | false | false | This is a group of bacterial glutamate-cysteine ligases that carry out the first step of the glutathione biosynthesis pathway according to the following equation: ATP + L-glutamate + L-cysteine = ADP + phosphate + L-glutamyl-L-cysteine (L-aminohexanoate can replace glutamate). | [
"GO:0004357",
"GO:0006750"
] | [
"glutamate-cysteine ligase activity",
"glutathione biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04262"
] | [
"Glu_cys_ligase"
] | [
7766
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.2.2",
"PWY-6840",
"PWY-7255",
"PWY-8043"
] | [
"EC:6.3.2.2",
"METACYC:PWY-6840",
"METACYC:PWY-7255",
"METACYC:PWY-8043"
] | 4 | [
"1v4g",
"1va6",
"2d32",
"2d33",
"3ln6",
"3ln7",
"3nzt"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriaceae",
"metagenomes"
] | [
7641,
6,
21,
98
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Glutamate--cysteine ligase | Glutamate--cysteine ligase | Glu_cys_ligase | 4 |
IPR007371 | 7,371 | Thiamin pyrophosphokinase, catalytic domain | TPK_catalytic | Domain | 14,934 | false | false | Thiamin pyrophosphokinase (TPK, ) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggests that t... | [
"GO:0004788",
"GO:0005524",
"GO:0009229"
] | [
"thiamine diphosphokinase activity",
"ATP binding",
"thiamine diphosphate biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF04263"
] | [
"TPK_catalytic"
] | [
14934
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.6.2",
"PWY-6898",
"PWY-6907",
"PWY-6908",
"PWY-7356",
"R-BTA-196819",
"R-CEL-196819",
"R-HSA-196819",
"R-MMU-196819",
"R-SCE-196819",
"R-SPO-196819"
] | [
"EC:2.7.6.2",
"METACYC:PWY-6898",
"METACYC:PWY-6907",
"METACYC:PWY-6908",
"METACYC:PWY-7356",
"REACTOME:R-BTA-196819",
"REACTOME:R-CEL-196819",
"REACTOME:R-HSA-196819",
"REACTOME:R-MMU-196819",
"REACTOME:R-SCE-196819",
"REACTOME:R-SPO-196819"
] | 11 | [
"1ig0",
"1ig3",
"2f17",
"2g9z",
"2hh9",
"2omk",
"3cq9",
"3ihk",
"3k94",
"3l8m",
"3lm8",
"3mel",
"3s4y",
"9hjc"
] | 14 | [
"PUB00009922"
] | [
"11435118"
] | [
"The crystal structure of yeast thiamin pyrophosphokinase."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
31,
9628,
5096,
179
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
4,
2,
6,
1,
1,
5,
7,
1,
1,
16
] | 12 | true | Domain | Thiamin pyrophosphokinase, catalytic domain | Thiamin pyrophosphokinase, catalytic domain | TPK_catalytic | 9 |
IPR007372 | 7,372 | Lipid/polyisoprenoid-binding, YceI-like | Lipid/polyisoprenoid-bd_YceI | Domain | 40,073 | false | false | This entry represents the lipid-binding protein YceI from Escherichia coli [ ] and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus [ ]. Both these proteins share a common domain with an 8-stranded β-barrel fold, which resembles the lipocalin fold, although no sequence homology exists with lipocali... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF04264",
"SM00867"
] | [
"YceI",
"YceI"
] | [
40049,
37476
] | 2 | [] | [] | [] | 0 | [
"1wub",
"1y0g",
"2fgs",
"2x32",
"2x34",
"3hpe",
"3q34",
"5ixg",
"5ixh",
"5w17",
"5w2d",
"5w2k",
"5w2r",
"5w2v",
"5w2x",
"5w2z",
"5w30",
"5w31",
"5w32",
"5w37",
"5w39",
"5w3a",
"5w3b",
"5w3c",
"7bwl"
] | 25 | [
"PUB00009923",
"PUB00032324"
] | [
"12107143",
"15741337"
] | [
"pH-dependent expression of periplasmic proteins and amino acid catabolism in Escherichia coli.",
"Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8."
] | [
2002,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10,
39558,
77,
428
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Lipid/polyisoprenoid-binding, YceI-like | Lipid/polyisoprenoid-binding, YceI-like | Lipid/polyisoprenoid-bd_YceI | 4 |
IPR007374 | 7,374 | ASCH domain | ASCH_domain | Domain | 16,544 | false | false | The ASCH domain adopts a β-barrel fold similar to that of the PUA domain ( ). It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation [ ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF04266",
"SM01022"
] | [
"ASCH",
"ASCH"
] | [
15705,
13197
] | 2 | [
"EC"
] | [
"3.5.1.135"
] | [
"EC:3.5.1.135"
] | 1 | [
"1s04",
"1t62",
"1te7",
"1wk2",
"1xne",
"2dp9",
"2e5o",
"2z0t",
"3iuw",
"3s9x",
"5guq",
"5gus",
"5y6b",
"5y6c",
"5y7d",
"6kir",
"6kis",
"6kit",
"8alz",
"8yew",
"8yey",
"8yfi",
"8yfj",
"8yxw",
"8yxx",
"9kyf",
"9kyg",
"9kyh",
"9kyi",
"9kyj",
"9kyk",
"9kyl"... | 32 | [
"PUB00044668"
] | [
"16322048"
] | [
"The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
608,
11738,
3969,
95,
134
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
23,
2,
2,
1,
5,
3,
8,
13,
13
] | 9 | true | Domain | ASCH domain | ASCH domain | ASCH_domain | 9 |
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