LiteFold/InterPro · Datasets at Hugging Face

IPR007502

7,502

Helicase-associated domain

Helicase-assoc_dom

Domain

84,263

false

This is the helicase associated domain (HA2) found as a diverse set of RNA helicases. It has an all α-helical fold that can be divided in two subdomains, an N-terminal degenerated winged helix (WH) and a C-terminal ratchet-like domain [ , , , ]. This domain collaborates with the RecA domains at the N-terminal in the fo...

[]

0

[ "SMART" ]

[ "SM00847" ]

[ "HA2" ]

[ 84263 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.13", "R-BTA-159236", "R-BTA-1810476", "R-BTA-3134963", "R-BTA-72163", "R-BTA-72187", "R-BTA-73856", "R-BTA-9833482", "R-CEL-159236", "R-CEL-3134963", "R-CEL-6791226", "R-CEL-72163", "R-CEL-72187", "R-CEL-73856", "R-CEL-9833482", "R-DDI-72163", "R-DME-1810476", "R-DME-3134963...

[ "EC:3.6.4.13", "REACTOME:R-BTA-159236", "REACTOME:R-BTA-1810476", "REACTOME:R-BTA-3134963", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-9833482", "REACTOME:R-CEL-159236", "REACTOME:R-CEL-3134963", "REACTOME:R-CEL-6791226", "REACTOME:R-CEL-72163", "...

42

[ "2xau", "3i4u", "3kx2", "5aor", "5d0u", "5gm6", "5i8q", "5jpt", "5lj5", "5lqw", "5lta", "5ltj", "5ltk", "5mq0", "5mqf", "5n8r", "5n8s", "5n8u", "5n8z", "5n90", "5n94", "5n96", "5n98", "5n9a", "5n9d", "5n9e", "5n9f", "5vha", "5vhc", "5vhd", "5vhe", "5wsg"...

159

[ "PUB00100845", "PUB00100846", "PUB00100847", "PUB00100848" ]

[ "26545078", "31409651", "32179686", "33243853" ]

[ "Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling.", "Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.", "Structural basis for DEAH-helicase activation by G-pat...

[ 2015, 2019, 2020, 2021 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 23486, 60624, 9, 144 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 108, 14, 49, 85, 2, 59, 48, 9, 52, 59, 7, 9, 156 ]

13

true

Domain

Helicase-associated domain

Helicase-assoc_dom

9

IPR007503

7,503

Protein of unknown function DUF530

DUF530

Family

137

false

This is a family of hypothetical archaeal proteins.

[]

0

[ "PFAM" ]

[ "PF04409" ]

[ "DUF530" ]

[ 137 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014496" ]

0

1

0

[ "Methanobacteriota", "bioreactor metagenome" ]

[ 136, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF530

DUF530

3

IPR007504

7,504

H/ACA ribonucleoprotein complex, subunit Gar1/Naf1

H/ACA_rnp_Gar1/Naf1

Family

9,221

false

H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular pr...

[ "GO:0001522", "GO:0042254" ]

[ "pseudouridine synthesis", "ribosome biogenesis" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF04410" ]

[ "Gar1" ]

[ 9221 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-171319", "R-HSA-6790901", "R-MMU-171319", "R-RNO-171319" ]

[ "REACTOME:R-HSA-171319", "REACTOME:R-HSA-6790901", "REACTOME:R-MMU-171319", "REACTOME:R-RNO-171319" ]

4

[ "2eqn", "2ey4", "2hvy", "2rfk", "2v3m", "3hay", "3mqk", "3u28", "3uai", "7bgb", "7trc", "7v9a", "8oue", "8ouf", "9g25", "9g28", "9qb2", "9qb3" ]

18

[ "PUB00049556", "PUB00053435", "PUB00053436", "PUB00088317" ]

[ "17612558", "16647858", "19917616", "10871366" ]

[ "The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.", "How a single protein complex accommodates many different H/ACA RNAs.", "The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modificatio...

[ 2007, 2006, 2009, 2000 ]

4

[]

[ "IPR040309" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 568, 8645, 8 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 2, 3, 4, 2, 6, 2, 5, 10, 2, 2, 14 ]

12

true

Family

H/ACA ribonucleoprotein complex, subunit Gar1/Naf1

H/ACA_rnp_Gar1/Naf1

8

IPR007505

7,505

PD-(D/E)XK nuclease superfamily 7

PDDEXK_7

Family

1,364

false

This domain has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches [ ]. The domain has two additional β-strands inserted to the core fold after the first core α-helix. It has been speculated that it could function as s methylation-dependent restriction [ ]. The d...

[]

0

[ "PFAM" ]

[ "PF04411" ]

[ "PDDEXK_7" ]

[ 1364 ]

1

[]

0

[]

0

[ "PUB00044133" ]

[ "17584917" ]

[ "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "unclassified sequences" ]

[ 1310, 42, 12 ]

3

[]

0

true

Family

PD-(D/E)XK nuclease superfamily 7

PDDEXK_7

9

IPR007506

7,506

Phosphomevalonate dehydratase large subunit-like domain

PMDh-L-like_dom

Domain

1,683

false

This entry represents a domain that covers the whole sequence in Phosphomevalonate dehydratase large subunit from Aeropyrum pernix (PMDh-L) and similar proteins mainly found in archaea, proteobacteria and fungi. PMDh-L is a component of a hydro-lyase that catalyses the dehydration of mevalonate 5-phosphate (MVA5P) to f...

[]

0

[ "CDD" ]

[ "cd01355" ]

[ "AcnX" ]

[ 1683 ]

1

[ "EC" ]

[ "4.2.1.182" ]

[ "EC:4.2.1.182" ]

1

[ "7cnp", "7cnq", "7cnr", "7cns", "7d2r" ]

5

[ "PUB00080857", "PUB00088769", "PUB00098043", "PUB00154970", "PUB00154971" ]

[ "14568143", "27929065", "30224495", "31924615", "36992929" ]

[ "Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysis.", "Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.", "Modified mevalonate pathway of the archaeon <i>Aeropyrum pernix</i> proceeds via <i>trans</i>-anhydrome...

[ 2003, 2016, 2018, 2020, 2023 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 318, 886, 452, 27 ]

4

[]

0

true

Domain

Phosphomevalonate dehydratase large subunit-like domain

PMDh-L-like_dom

5

IPR007507

7,507

3-deoxy-D-manno-octulosonic-acid transferase, N-terminal

Glycos_transf_N

Domain

15,378

false

This is a domain found in proteins that transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. Proteins bearing this domain transfer UDP, ADP, GDP or CMP linked sugars. This region is flanked at the N terminus by a signal peptide and at the C terminus by ...

[]

0

[ "PFAM" ]

[ "PF04413" ]

[ "Glycos_transf_N" ]

[ 15378 ]

1

[ "EC", "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.99", "2.4.99.12", "GenProp0204", "GenProp1325", "GenProp1647", "GenProp1684", "PWY-7675", "PWY-8074", "PWY-8246", "PWY-8284" ]

[ "EC:2.4.99", "EC:2.4.99.12", "GP:GenProp0204", "GP:GenProp1325", "GP:GenProp1647", "GP:GenProp1684", "METACYC:PWY-7675", "METACYC:PWY-8074", "METACYC:PWY-8246", "METACYC:PWY-8284" ]

10

[ "2xci", "2xcu" ]

2

[ "PUB00009991" ]

[ "10952982" ]

[ "3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14256, 814, 308 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 2, 9 ]

4

true

Domain

3-deoxy-D-manno-octulosonic-acid transferase, N-terminal

Glycos_transf_N

6

IPR007508

7,508

D-aminoacyl-tRNA deacylase DtdA

DtdA

Family

1,890

false

D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules. Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tR...

[ "GO:0016788", "GO:0051499" ]

[ "hydrolase activity, acting on ester bonds", "D-aminoacyl-tRNA deacylase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04414", "PTHR34667" ]

[ "tRNA_deacylase", "" ]

[ 1819, 1822 ]

2

[ "EC" ]

[ "3.1.1.96" ]

[ "EC:3.1.1.96" ]

1

[ "1yqe", "2gfq" ]

2

[ "PUB00045161", "PUB00053895" ]

[ "17251192", "16844682" ]

[ "GEK1, a gene product of Arabidopsis thaliana involved in ethanol tolerance, is a D-aminoacyl-tRNA deacylase.", "Identification in archaea of a novel D-Tyr-tRNATyr deacylase." ]

[ 2007, 2006 ]

2

[]

[ "IPR018033" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 841, 53, 941, 55 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 9, 13 ]

3

true

Family

D-aminoacyl-tRNA deacylase DtdA

DtdA

1

IPR007509

7,509

Protein of unknown function DUF515

DUF515

Family

122

false

This is a family of hypothetical archaeal proteins.

[]

0

[ "PFAM" ]

[ "PF04415" ]

[ "DUF515" ]

[ 122 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "Vagococcus bubulae", "bioreactor metagenome" ]

[ 120, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF515

DUF515

4

IPR007511

7,511

Protein of unknown function DUF501

DUF501

Family

5,395

false

Family of uncharacterised bacterial proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04417", "PTHR37163" ]

[ "DUF501", "" ]

[ 5395, 5191 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4897, 319, 179 ]

3

[]

0

true

Family

Protein of unknown function DUF501

DUF501

5

IPR007512

7,512

MICOS complex subunit Mic10

Mic10

Family

4,337

false

Mic10 (also known as MINOS1) is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane [ ].

[ "GO:0005743", "GO:0061617" ]

[ "mitochondrial inner membrane", "MICOS complex" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04418", "PTHR21304" ]

[ "DUF543", "" ]

[ 4310, 4127 ]

2

[ "REACTOME" ]

[ "R-HSA-8949613" ]

[ "REACTOME:R-HSA-8949613" ]

1

[]

0

[ "PUB00083140" ]

[ "22114354" ]

[ "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 4335, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 5, 5, 1, 1, 2, 2, 1, 1, 9 ]

12

true

Family

MICOS complex subunit Mic10

Mic10

8

IPR007513

7,513

Small EDRK-rich factor-like, N-terminal

SERF-like_N

Domain

7,549

false

This entry represents the N-terminal domain of Small EDRK-rich factors (SERFs), including SERF1/2 from human. Proteins containing this domain are short proteins that are rich in aspartate, glutamate, lysine and arginine [ ]. SERF1/2 are positive regulators of amyloid protein aggregation and proteotoxicity; they induce ...

[]

0

[ "PFAM" ]

[ "PF04419" ]

[ "SERF-like_N" ]

[ 7549 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-212436", "R-HSA-212436", "R-MMU-212436" ]

[ "REACTOME:R-GGA-212436", "REACTOME:R-HSA-212436", "REACTOME:R-MMU-212436" ]

3

[ "1wvk", "9dt0" ]

2

[ "PUB00009992", "PUB00101830", "PUB00101831", "PUB00101832" ]

[ "9731538", "22854022", "20723760", "31034892" ]

[ "Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics.", "SERF protein is a direct modifier of amyloid fiber assembly.", "Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.", "Increased Aggregation Tendency of Alpha-Synuclein in a Fully Diso...

[ 1998, 2012, 2010, 2019 ]

4

[]

0

null

[ "Eukaryota" ]

[ 7549 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 4, 5, 6, 12, 10, 2, 17, 7, 1, 1, 17 ]

12

true

Domain

Small EDRK-rich factor-like, N-terminal

SERF-like_N

7

IPR007515

7,515

Mss4

Family

2,025

false

MSS4 (mammalian suppressor of Sec4) is an evolutionarily highly conserved protein, which is expressed in all mammalian tissues. Although it was first proposed to function as a guanine exchange factor (GEF) for Rab GTPases, it was soon described as a quite inefficient GEF and was thus suggested to function rather as a c...

[ "GO:0005085", "GO:0007264" ]

[ "guanyl-nucleotide exchange factor activity", "small GTPase-mediated signal transduction" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE", "PANTHER", "CDD" ]

[ "PF04421", "PS51796", "PTHR13276", "cd00246" ]

[ "Mss4", "MSS4", "", "RabGEF" ]

[ 1992, 2009, 1692, 364 ]

4

[]

0

[ "1fwq", "1hxr", "2fu5" ]

3

[ "PUB00014250", "PUB00019890", "PUB00040811", "PUB00084256" ]

[ "11258916", "7651540", "16541104", "22495352" ]

[ "A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release.", "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface.", "Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.", "Mss4 pr...

[ 2001, 1995, 2006, 2012 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2025 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 2, 2, 3, 3, 1, 1 ]

8

true

Family

Mss4

7

IPR007516

7,516

Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal

Co_F420_Hydgase/DH_bsu_N

Domain

4,274

false

Coenzyme F420 hydrogenase ( ) reduces the low-potential two-electron acceptor coenzyme F420. This entry contains the N termini of F420 hydrogenase and dehydrogenase beta subunits [ , ]. The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain ( , ) is also represented in this entry [ ]. This regio...

[]

0

[ "PFAM" ]

[ "PF04422" ]

[ "FrhB_FdhB_N" ]

[ 4274 ]

1

[]

0

[ "3zfs", "4ci0", "4omf", "5dqr", "6qgr", "6qgt", "6qii", "7bkb", "7bkc", "7bkd", "7bke", "7np8", "7npa", "8riu", "8rja", "8rvu", "8rvv", "8rvy", "9r51", "9r52", "9r5i", "9r6z" ]

22

[ "PUB00009571", "PUB00009738", "PUB00009994" ]

[ "2207102", "3531194", "10751389" ]

[ "Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.", "Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium form...

[ 1990, 1986, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1238, 2071, 756, 209 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 6 ]

3

true

Domain

Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal

Co_F420_Hydgase/DH_bsu_N

6

IPR007518

7,518

MINDY deubiquitinase

MINDY

Family

5,997

false

This entry represents a group of deubiquitinating (DUB) enzymes known as the MINDY family (MIU-containing novel DUB). Ubiquitin (Ub) is released one molecule at a time from the distal end of proteins with Lys48-linked polyubiquitin chains. Long polyubiquitin chains are preferred. The catalytic Cys and His residues have...

[ "GO:0004843", "GO:1990380" ]

[ "cysteine-type deubiquitinase activity", "K48-linked deubiquitinase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PANTHER" ]

[ "PTHR18063" ]

[ "" ]

[ 5997 ]

1

[ "EC" ]

[ "3.4.19.12" ]

[ "EC:3.4.19.12" ]

1

[ "5jkn", "5jqs", "6k6l", "6tuv", "6txb", "6y6r", "6yjg", "6z49", "6z7v", "6z90", "7npi" ]

11

[ "PUB00081935" ]

[ "27292798" ]

[ "MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5997 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 10, 2, 3, 6, 5, 1, 13, 9, 2, 1, 53 ]

11

true

Family

MINDY deubiquitinase

MINDY

2

IPR007519

7,519

Bul1, N-terminal

Bul1_N

Domain

600

false

This domain is the N terminus of Saccharomyces cerevisiae (Baker's yeast) Bul1 and Bul2. Bul1 binds the ubiquitin ligase Rsp5, via an N-terminal PPSY motif (157-160 in ) [ ]. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1 [ ], degradation of Rog1 in...

[]

0

[ "PFAM" ]

[ "PF04425" ]

[ "Bul1_N" ]

[ 600 ]

1

[]

0

[]

0

[ "PUB00009998", "PUB00009999", "PUB00010000", "PUB00010116" ]

[ "9931424", "10958669", "10366593", "11500494" ]

[ "The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions.", "Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5.", "A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisia...

[ 1998, 2000, 1999, 2001 ]

4

[]

0

null

[ "Dikarya" ]

[ 600 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 3 ]

1

true

Domain

Bul1, N-terminal

Bul1_N

8

IPR007521

7,521

Choline kinase, N-terminal

Choline_kin_N

Domain

1,291

false

This domain is found N-terminal to choline/ethanolamine kinase regions in some plant and fungal choline kinase enzymes ( ). This region is only found in some members of the choline kinase family, and is therefore unlikely to contribute to catalysis.

[ "GO:0016773" ]

[ "phosphotransferase activity, alcohol group as acceptor" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04428" ]

[ "Choline_kin_N" ]

[ 1291 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.32", "GenProp1351", "PWY-7782", "PWY-7818", "PWY-7886", "R-SCE-1483191", "R-SCE-1483213", "R-SPO-1483191", "R-SPO-1483213" ]

[ "EC:2.7.1.32", "GP:GenProp1351", "METACYC:PWY-7782", "METACYC:PWY-7818", "METACYC:PWY-7886", "REACTOME:R-SCE-1483191", "REACTOME:R-SCE-1483213", "REACTOME:R-SPO-1483191", "REACTOME:R-SPO-1483213" ]

9

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1291 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 3, 7, 2, 1 ]

5

true

Domain

Choline kinase, N-terminal

Choline_kin_N

8

IPR007522

7,522

CRISPR-associated protein TM1795

CRISPR-assoc_prot_TM1795

Family

751

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. This entry represents the N-terminal region from a family of Cas proteins that includes TM1795 from Thermotoga maritima. The N-terminal half of thes...

[]

0

[ "NCBIFAM" ]

[ "TIGR01894" ]

[ "cas_TM1795_cmr1" ]

[ 751 ]

1

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0316" ]

[ "GP:GenProp0021", "GP:GenProp0316" ]

2

[ "4l6u", "4w8x", "4w8z", "6s6b", "6s8b", "6s8e", "6s91", "6sh8", "6shb", "6sic" ]

10

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 124, 618, 9 ]

3

[]

0

true

Family

CRISPR-associated protein TM1795

CRISPR-assoc_prot_TM1795

7

IPR007523

7,523

NDUFAF3/Mth938 domain-containing protein

NDUFAF3/AAMDC

Family

10,298

false

This entry includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) [ ], and the Mth938 domain-containing protein [ ]. The crystal structure of NDUFAF3 revealed a 3-layer β+α/β/α topology [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04430", "PTHR21192" ]

[ "DUF498", "" ]

[ 10215, 8451 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6799198", "R-DME-6799198", "R-HSA-6799198", "R-MMU-6799198", "R-RNO-6799198", "R-XTR-6799198" ]

[ "REACTOME:R-BTA-6799198", "REACTOME:R-DME-6799198", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-6799198", "REACTOME:R-XTR-6799198" ]

6

[ "1ihn", "2ab1", "2cyj", "2fi9", "2fvt", "2gm2", "2k2e", "2q4q", "3cpk" ]

9

[ "PUB00005074", "PUB00019473", "PUB00043561", "PUB00045437", "PUB00053862", "PUB00076352" ]

[ "1470679", "11746696", "10940377", "18394423", "19463981", "22279136" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound...

[ 1992, 2001, 2000, 2008, 2009, 2012 ]

6

[]

[ "IPR034095", "IPR034096" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Mimiviridae", "unclassified sequences" ]

[ 178, 4994, 4977, 4, 145 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 13, 2, 3, 1, 7, 8, 1, 7, 12, 9 ]

10

true

Family

NDUFAF3/Mth938 domain-containing protein

NDUFAF3/AAMDC

8

IPR007524

7,524

Pectate lyase, N-terminal

Pec_lyase_N

Domain

2,284

false

This region is found N-terminal to the pectate lyase domain ( ) in some plant pectate lyase enzymes.

[ "GO:0030570" ]

[ "pectate lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04431" ]

[ "Pec_lyase_N" ]

[ 2284 ]

1

[ "EC" ]

[ "4.2.2.2" ]

[ "EC:4.2.2.2" ]

1

[]

0

[]

0

[]

0

null

[ "Magnoliopsida" ]

[ 2284 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 12, 25 ]

3

true

Domain

Pectate lyase, N-terminal

Pec_lyase_N

7

IPR007525

7,525

Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal

FrhB_FdhB_C

Domain

5,641

false

Coenzyme F420 hydrogenase ( ) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C-termini of F420 hydrogenase and dehydrogenase beta subunits [ , ]. The C terminus of Methanobacterium formicicum formate dehydrogenase beta chain ( , ) is also represented in this entry [ ]. This regi...

[]

0

[ "PFAM" ]

[ "PF04432" ]

[ "FrhB_FdhB_C" ]

[ 5641 ]

1

[]

0

[ "3zfs", "4ci0", "4omf", "5dqr", "6qgr", "6qgt", "6qii", "7bkb", "7bkc", "7bkd", "7bke", "7np8", "7npa", "8riu", "8rja", "8rvu", "8rvv", "8rvy", "9r51", "9r52", "9r5i", "9r6z" ]

22

[ "PUB00009571", "PUB00009738", "PUB00009994" ]

[ "2207102", "3531194", "10751389" ]

[ "Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.", "Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium form...

[ 1990, 1986, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1269, 3353, 750, 269 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 5 ]

3

true

Domain

Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal

FrhB_FdhB_C

7

IPR007526

7,526

SWIRM domain

SWIRM

Domain

24,514

false

The SWIRM domain is a small α-helical domain of about 85 amino acid residues found in eukaryotic chromosomal proteins. It is named after the proteins SWI3, RSC8 and MOIRA in which it was first recognised. This domain mediates protein-protein interactions in the assembly of chromatin-protein complexes [ , ]. The yeast S...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF04433", "PS50934" ]

[ "SWIRM", "SWIRM" ]

[ 22752, 24096 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50934", "R-BTA-9772755", "R-CEL-3214842", "R-DDI-5689901", "R-DME-3214815", "R-DME-5625886", "R-DME-9018519", "R-DME-9764725", "R-DME-983231", "R-DRE-5689901", "R-HSA-3214815", "R-HSA-3214842", "R-HSA-3214847", "R-HSA-3214858", "R-HSA-5625886", "R-HSA-5689603", "R-HSA-5689901", ...

[ "PROSITEDOC:PDOC50934", "REACTOME:R-BTA-9772755", "REACTOME:R-CEL-3214842", "REACTOME:R-DDI-5689901", "REACTOME:R-DME-3214815", "REACTOME:R-DME-5625886", "REACTOME:R-DME-9018519", "REACTOME:R-DME-9764725", "REACTOME:R-DME-983231", "REACTOME:R-DRE-5689901", "REACTOME:R-HSA-3214815", "REACTOME:R...

66

[ "2aqe", "2aqf", "2com", "2cuj", "2dce", "2dw4", "2ejr", "2elj", "2fq3", "2h94", "2hko", "2iw5", "2l3d", "2uxn", "2uxx", "2v1d", "2x0l", "2xaf", "2xag", "2xah", "2xaj", "2xaq", "2xas", "2y48", "2z3y", "2z5u", "3abt", "3abu", "3zms", "3zmt", "3zmu", "3zmv"...

165

[ "PUB00040775", "PUB00057211" ]

[ "16461455", "12186646" ]

[ "Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes.", "The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities." ]

[ 2006, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Staphylothermus marinus", "ecological metagenomes" ]

[ 34, 24477, 1, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 51, 7, 17, 9, 39, 14, 4, 27, 23, 5, 7, 76 ]

12

true

Domain

SWIRM domain

SWIRM

3

IPR007527

7,527

Zinc finger, SWIM-type

Znf_SWIM

Domain

93,701

false

This entry represents the SWIM (SWI2/SNF2 and MuDR) zinc-binding domain, which is found in a variety of prokaryotic and eukaryotic proteins, such as mitogen-activated protein kinase kinase kinase 1 (or MEKK1). It is also found in the related protein MEX (MEKK1-related protein X), a testis-expressed protein that acts as...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF04434", "PS50966" ]

[ "SWIM", "ZF_SWIM" ]

[ 58532, 92933 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50966", "R-HSA-166058", "R-HSA-2871796", "R-HSA-9010553", "R-HSA-933542", "R-HSA-975138", "R-HSA-975871", "R-MMU-166058", "R-MMU-2871796", "R-MMU-975138", "R-MMU-975871", "R-RNO-166058", "R-RNO-2871796", "R-RNO-975138", "R-RNO-975871" ]

[ "PROSITEDOC:PDOC50966", "REACTOME:R-HSA-166058", "REACTOME:R-HSA-2871796", "REACTOME:R-HSA-9010553", "REACTOME:R-HSA-933542", "REACTOME:R-HSA-975138", "REACTOME:R-HSA-975871", "REACTOME:R-MMU-166058", "REACTOME:R-MMU-2871796", "REACTOME:R-MMU-975138", "REACTOME:R-MMU-975871", "REACTOME:R-RNO-1...

15

[]

0

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00035845", "PUB00035846" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "16522193", "16710300" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 2006, 2006 ]

8

[]

[ "IPR006564" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2369, 22893, 67960, 152, 327 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 278, 5, 16, 1, 1, 19, 20, 5, 548, 27, 1, 106 ]

12

true

Domain

Zinc finger, SWIM-type

Znf_SWIM

7

IPR007528

7,528

RINT-1/Tip20

RINT1_Tip20

Family

5,226

false

This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity [ ]. They are part of the CATCHR (complexes associated with ...

[ "GO:0006890", "GO:0070939" ]

[ "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "Dsl1/NZR complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PROFILE", "PANTHER" ]

[ "PF04437", "PS51386", "PTHR13520" ]

[ "RINT1_TIP1", "RINT1_TIP20", "" ]

[ 5031, 4967, 5106 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6811434", "R-HSA-6811434", "R-MMU-6811434", "R-SCE-6811434", "R-SPO-6811434" ]

[ "REACTOME:R-DME-6811434", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-6811434", "REACTOME:R-SCE-6811434", "REACTOME:R-SPO-6811434" ]

5

[ "3fhn", "6wc3", "8eki" ]

3

[ "PUB00010001", "PUB00010117", "PUB00043787", "PUB00043788", "PUB00051798", "PUB00072705", "PUB00072936", "PUB00100047" ]

[ "8334998", "11096100", "16600870", "16571679", "19151722", "17194767", "24118572", "34061181" ]

[ "The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.", "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.", "The Rb-related p130 protein controls telomere lengthening through a...

[ 1993, 2001, 2006, 2006, 2009, 2006, 2013, 2021 ]

8

[]

0

null

[ "Eukaryota", "Microbacterium maritypicum", "marine sediment metagenome" ]

[ 5223, 2, 1 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 9, 1, 2, 3, 2, 1, 7, 5, 1, 1, 10 ]

11

true

Family

RINT-1/Tip20

RINT1_Tip20

3

IPR007530

7,530

Aminoglycoside 6-adenylyltransferase

Aminoglycoside_adenylylTfrase

Family

3,028

false

Also known as aminoglycoside 6-adenylyltransferase ( ), this protein confers resistance to aminoglycoside antibiotics.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04439", "PIRSF000812" ]

[ "Adenyl_transf", "AAD" ]

[ 3028, 1634 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.-", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179" ]

[ "EC:2.7.7.-", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719", "METACYC:PWY-7735", "METACYC:PWY-7737", "METACYC:PWY-7769", "METACYC:PWY-7...

18

[ "2pbe", "8vxb" ]

2

[]

0

[]

0

null

[ "Bacteria", "Corchorus olitorius", "Salinirubellus salinus", "Transposon Tn4551", "metagenomes" ]

[ 2994, 1, 1, 1, 31 ]

5

[]

0

true

Family

Aminoglycoside 6-adenylyltransferase

Aminoglycoside_adenylylTfrase

2

IPR007532

7,532

Poxvirus early transcription factor, large subunit

Poxvirus_early-TF_lsu

Family

172

false

The poxvirus early transcription factor (VETF), in addition to the viral RNA polymerase, is required for efficient transcription of early genes in vitro . VETF is a heterodimeric protein that binds specifically to early gene promoters. The heterodimer is comprised of an 82kDa (this family) subunit and a 70kDa subunit.

[ "GO:0045893" ]

[ "positive regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04441" ]

[ "Pox_VERT_large" ]

[ 172 ]

1

[]

0

[ "6rfl", "7amv", "8c8h", "8rqk" ]

4

[]

0

[]

0

null

[ "Poxviridae" ]

[ 172 ]

1

[]

0

true

Family

Poxvirus early transcription factor, large subunit

Poxvirus_early-TF_lsu

3

IPR007533

7,533

Cytochrome c oxidase assembly protein CtaG/Cox11

Cyt_c_oxidase_assmbl_CtaG

Family

10,994

false

Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in s...

[ "GO:0005507" ]

[ "copper ion binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00155", "PF04442", "PIRSF005413" ]

[ "CtaG", "CtaG_Cox11", "COX11" ]

[ 6140, 10994, 6991 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0614", "R-BTA-9864848", "R-HSA-9864848", "R-MMU-9864848" ]

[ "GP:GenProp0614", "REACTOME:R-BTA-9864848", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

4

[ "1so9", "1sp0" ]

2

[ "PUB00010096", "PUB00010118" ]

[ "10617659", "12063264" ]

[ "Cox11p is required for stable formation of the Cu(B) and magnesium centers of cytochrome c oxidase.", "Yeast Cox11, a protein essential for cytochrome c oxidase assembly, is a Cu(I)-binding protein." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6331, 4584, 79 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 1, 1, 4, 2, 1, 5, 2, 1, 2, 4 ]

12

true

Family

Cytochrome c oxidase assembly protein CtaG/Cox11

Cyt_c_oxidase_assmbl_CtaG

8

IPR007534

7,534

Acyl-protein synthetase, LuxE

LuxE

Domain

3,573

false

LuxE is an acyl-protein synthetase found in bioluminescent bacteria. LuxE catalyses the formation of an acyl-protein thiolester from a fatty acid and a protein. This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-cataly...

[ "GO:0047474", "GO:0008218" ]

[ "long-chain fatty acid--protein ligase activity", "bioluminescence" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04443" ]

[ "LuxE" ]

[ 3573 ]

1

[ "EC", "METACYC" ]

[ "6.2.1.19", "PWY-7723" ]

[ "EC:6.2.1.19", "METACYC:PWY-7723" ]

2

[ "7xc6" ]

1

[ "PUB00010003", "PUB00010004" ]

[ "2023262", "8941351" ]

[ "Identification of the acyl transfer site of fatty acyl-protein synthetase from bioluminescent bacteria.", "Nucleotide sequence and functional analysis of the luxE gene encoding acyl-protein synthetase of the lux operon from Photobacterium leiognathi." ]

[ 1991, 1996 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Linnemannia gamsii", "metagenomes" ]

[ 27, 3498, 1, 47 ]

4

[]

0

true

Domain

Acyl-protein synthetase, LuxE

LuxE

3

IPR007536

7,536

Ribosomal RNA small subunit methyltransferase J

16SrRNA_methylTrfase_J

Family

7,396

false

Ribosomal RNA small subunit methyltransferase J specifically methylates the guanosine in position 1516 of 16S rRNA in Escherichia coli [ ].

[ "GO:0008990", "GO:0031167" ]

[ "rRNA (guanine-N2-)-methyltransferase activity", "rRNA methylation" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01523", "PF04445", "PTHR36112" ]

[ "16SrRNA_methyltr_J", "SAM_MT", "" ]

[ 5192, 7380, 7341 ]

3

[ "EC" ]

[ "2.1.1.242" ]

[ "EC:2.1.1.242" ]

1

[ "2oyr", "2pgx", "2pkw", "2r6z" ]

4

[ "PUB00057487" ]

[ "22079366" ]

[ "YhiQ is RsmJ, the methyltransferase responsible for methylation of G1516 in 16S rRNA of E. coli." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctiv53", "unclassified sequences" ]

[ 7258, 81, 1, 56 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribosomal RNA small subunit methyltransferase J

16SrRNA_methylTrfase_J

4

IPR007537

7,537

tRNAHis guanylyltransferase Thg1

tRNAHis_GuaTrfase_Thg1

Family

5,761

false

tRNA His molecules are unusual in having an extra 5' GMP residue (G(-1)) that, in eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G(-1) residue is a rare example of nucleotide addition occurring at an RNA 5' end in a normal phosphodiester linkage. In Saccharomyces cerevisiae, YGR024...

[ "GO:0000287", "GO:0008193", "GO:0006400" ]

[ "magnesium ion binding", "tRNA guanylyltransferase activity", "tRNA modification" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF028980", "PTHR12729" ]

[ "tRNAHis_guanylyltransferase", "" ]

[ 2791, 5761 ]

2

[ "EC", "REACTOME" ]

[ "2.7.7.79", "R-HSA-6782315" ]

[ "EC:2.7.7.79", "REACTOME:R-HSA-6782315" ]

2

[ "3otb", "3otc", "3otd", "3ote", "3wbz", "3wc0", "3wc1", "3wc2", "4kgk", "4kgm", "5axk", "5axl", "5axm", "5axn", "5xox", "7cv1" ]

16

[ "PUB00020433", "PUB00035946", "PUB00058206", "PUB00058207" ]

[ "14633974", "15821142", "20080734", "16731615" ]

[ "tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis.", "The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae.", "Tem...

[ 2003, 2005, 2010, 2006 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 199, 575, 4871, 90, 26 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 32, 2, 1, 4, 4, 1, 4, 6, 1, 1, 9 ]

11

true

Family

tRNAHis guanylyltransferase Thg1

tRNAHis_GuaTrfase_Thg1

4

IPR007538

7,538

dATP/dGTP diphosphohydrolase MazZ

dATP/dGTP_dipphydrolase_MazZ

Domain

744

false

This domain is found in phage proteins, such as from Acinetobacter phage SH-Ab 15497 and from cyanophage S-2L, which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity [ ]. This domain has...

[]

0

[ "PFAM" ]

[ "PF04447" ]

[ "dATP-dGTP_PPHyd" ]

[ 744 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.9", "PWY-6545", "PWY-7184", "PWY-7187", "PWY-7206", "PWY-7821" ]

[ "EC:3.6.1.9", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7187", "METACYC:PWY-7206", "METACYC:PWY-7821" ]

6

[ "7ody" ]

1

[ "PUB00097959", "PUB00099838" ]

[ "33926954", "34354070" ]

[ "A widespread pathway for substitution of adenine by diaminopurine in phage genomes.", "Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA." ]

[ 2021, 2021 ]

2

[]

0

null

[ "Bacteria", "Viruses", "ecological metagenomes" ]

[ 596, 133, 15 ]

3

[]

0

true

Domain

dATP/dGTP diphosphohydrolase MazZ

dATP/dGTP_dipphydrolase_MazZ

6

IPR007539

7,539

Domain of unknown function DUF551

DUF551

Domain

2,811

false

This entry represents the C terminus of a protein of unknown function, found in dsDNA viruses with no RNA stage, including bacteriophages lambda and P22, and also in some Escherichia coli prophages.

[]

0

[ "PFAM" ]

[ "PF04448" ]

[ "DUF551" ]

[ 2811 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2319, 4, 386, 102 ]

4

[]

0

true

Domain

Domain of unknown function DUF551

DUF551

9

IPR007540

7,540

Fimbrial major subunit, CS1-type

Fimbrial_CS1-type

Family

1,602

false

Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major ...

[ "GO:0009289" ]

[ "pilus" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04449" ]

[ "Fimbrial_CS1" ]

[ 1602 ]

1

[]

0

[ "3f83", "3f84", "3f85", "4hji", "4y2l", "4y2n", "4y2o", "6nrv", "8ehr", "8ehs" ]

10

[ "PUB00010006", "PUB00010008" ]

[ "10094617", "10417651" ]

[ "New tools in an old trade: CS1 pilus morphogenesis.", "Multiple insertions of fimbrial operons correlate with the evolution of Salmonella serovars responsible for human disease." ]

[ 1998, 1999 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1598, 4 ]

2

[]

0

true

Family

Fimbrial major subunit, CS1-type

Fimbrial_CS1-type

5

IPR007541

7,541

Uncharacterised protein family, basic secretory protein

Uncharacterised_BSP

Family

4,983

false

Proteins in this entry include basic secretory proteins (BSPs) believed to be part of the plants defence mechanism against pathogens [ ]. In plants, this group of proteins are known as PR-17 family, including At2g15120 from Arabidopsis, NtPRp27 from Nicotiana tabacum and StPRp27 from potatoes [ , ]. This entry also inc...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04450", "PTHR33321" ]

[ "BSP", "" ]

[ 4970, 4684 ]

2

[]

0

[]

0

[ "PUB00010009", "PUB00093362", "PUB00093363" ]

[ "10202814", "21667110", "20569319" ]

[ "Abscisic acid-induced secretory proteins in suspension-cultured cells of winter wheat.", "A potato pathogenesis-related protein gene, StPRp27, contributes to race-nonspecific resistance against Phytophthora infestans.", "The molecular characterization of two barley proteins establishes the novel PR-17 family o...

[ 1999, 2012, 2002 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1067, 3908, 8 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 2, 13, 11 ]

4

true

Family

Uncharacterised protein family, basic secretory protein

Uncharacterised_BSP

4

IPR007542

7,542

Major capsid protein, C-terminal

MCP_C

Domain

3,733

false

The entry includes major capsid proteins (vp54 and vp72) found in Iridoviruses, Phycodnaviruses, Asfarviruses and Ascoviruses, which are all type II dsDNA viruses with no RNA stage. This is the most abundant structural protein and can account for up to 45% of virion protein [ ]. The structure of vp54 has been determine...

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04451" ]

[ "Capsid_NCLDV" ]

[ 3733 ]

1

[]

0

[ "1m4x", "3kk5", "5j7o", "5j7u", "5j7v", "5tip", "5tiq", "6ku9", "6l2t", "6ncl", "6ojn", "7yjl", "8h2i", "8hif", "8rbs", "8rbt", "8y3o", "8y3p", "8y3q", "8y3r", "8zl9" ]

21

[ "PUB00010097", "PUB00022136" ]

[ "10082389", "12411581" ]

[ "Comparison of the major capsid protein genes, terminal redundancies, and DNA-DNA homologies of two New Zealand iridoviruses.", "The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus." ]

[ 1999, 2002 ]

2

[]

0

null

[ "Eukaryota", "Viruses", "metagenomes" ]

[ 74, 2978, 681 ]

3

[]

0

true

Domain

Major capsid protein, C-terminal

MCP_C

5

IPR007543

7,543

LptD, C-terminal

LptD_C

Domain

10,979

false

Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. Struct...

[ "GO:0061024", "GO:0019867" ]

[ "membrane organization", "outer membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04453" ]

[ "LptD" ]

[ 10979 ]

1

[ "GP" ]

[ "GenProp1079" ]

[ "GP:GenProp1079" ]

1

[ "4n4r", "4q35", "4rhb", "5iv8", "5iv9", "5iva", "5ixm", "7omm", "8h1r", "8h1s", "9fz5", "9i92", "9i93", "9i94", "9i95", "9i96", "9i97", "9i98", "9kn3", "9q8n" ]

20

[ "PUB00091048", "PUB00091049", "PUB00091050", "PUB00091051" ]

[ "24990744", "27161977", "27922123", "21257904" ]

[ "Structural basis for outer membrane lipopolysaccharide insertion.", "Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens.", "LptD is a promising vaccine antigen and potential immunotherapeutic target for protection against Vibrio species infection.", "The comp...

[ 2014, 2016, 2016, 2011 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10791, 17, 171 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

LptD, C-terminal

LptD_C

8

IPR007544

7,544

Type 1 encapsulin shell protein

ENCAP

Family

2,350

false

This protein family includes Type 1 encapsulin shell proteins found in prokaryotes. These proteins form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-termina...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF041155", "PF04454", "PIRSF019254" ]

[ "encap_f1", "Linocin_M18", "CFP29" ]

[ 2216, 2350, 2018 ]

3

[ "GP" ]

[ "GenProp0810" ]

[ "GP:GenProp0810" ]

1

[ "2e0z", "3dkt", "4pt2", "6i9g", "6nj8", "6wkv", "7bcv", "7boj", "7k5w", "7kq5", "7lii", "7lij", "7lik", "7lil", "7lim", "7lis", "7lit", "7mh2", "7mu1", "7odw", "7oe2", "7oeu", "7p1t", "7phm", "7s20", "7s21", "7s2t", "7s4q", "8dn9", "8dna", "8dnl", "8ika"...

55

[ "PUB00074202", "PUB00100749" ]

[ "19172747", "28263314" ]

[ "Structural basis of enzyme encapsulation into a bacterial nanocompartment.", "Widespread distribution of encapsulin nanocompartments reveals functional diversity." ]

[ 2008, 2017 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Diploscapter pachys", "metagenomes" ]

[ 98, 2234, 1, 17 ]

4

[]

0

true

Family

Type 1 encapsulin shell protein

ENCAP

9

IPR007545

7,545

LOR/SDH bifunctional enzyme, conserved domain

LOR/SDH_bifunc_enz_cons_dom

Domain

1,956

false

Lysine-oxoglutarate reductase/Saccharopine dehydrogenase (LOR/SDH) is a bifunctional enzyme. This conserved region is commonly found immediately N-terminal to saccharopine dehydrogenase conserved region ( ) in eukaryotes [ , ]. It is also found in Bifunctional arginine dihydrolase/ornithine cyclodeaminase ArgZ and ArgE...

[]

0

[ "PFAM", "CDD" ]

[ "PF04455", "cd12144" ]

[ "Saccharop_dh_N", "SDH_N_domain" ]

[ 1956, 1769 ]

2

[ "EC", "METACYC" ]

[ "4.3.1.12", "PWY-4981" ]

[ "EC:4.3.1.12", "METACYC:PWY-4981" ]

2

[ "3mgj", "6juy", "6lrf", "6lrg", "6lrh" ]

5

[ "PUB00010016", "PUB00010017", "PUB00154571", "PUB00154572", "PUB00154573" ]

[ "9426595", "9654071", "29632414", "30636068", "30656751" ]

[ "Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana: nucleotide sequence and characterization.", "Structure and regulation of the bifunctional enzyme lysine-oxoglutarate reductase-saccharopine dehydrogenase in maize.", "The cyanobacterial ornithine-ammonia cycle involves an ...

[ 1997, 1998, 2018, 2019, 2019 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 458, 601, 867, 30 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 3, 24 ]

3

true

Domain

LOR/SDH bifunctional enzyme, conserved domain

LOR/SDH_bifunc_enz_cons_dom

4

IPR007546

7,546

Protein of unknown function DUF503

DUF503

Family

5,648

false

This is a family of conserved hypothetical bacterial proteins, including TT1725 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579), which has a ferredoxin-like α+β-sandwich fold [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04456", "PTHR36441" ]

[ "DUF503", "" ]

[ 5648, 5382 ]

2

[]

0

[ "1j27" ]

1

[ "PUB00026233" ]

[ "14579367" ]

[ "Crystal structure of a hypothetical protein, TT1725, from Thermus thermophilus HB8 at 1.7 A resolution." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus litoralis", "metagenomes" ]

[ 5532, 2, 1, 113 ]

4

[]

0

true

Family

Protein of unknown function DUF503

DUF503

6

IPR007547

7,547

Uncharacterised protein family UPF0248

UPF0248

Family

170

false

This is a family of uncharacterised archaeal proteins, which contain the MJ1316 RNA cyclic group end recognition domain ( ).

[]

0

[ "HAMAP" ]

[ "MF_01245" ]

[ "UPF0248" ]

[ 170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 170 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0248

UPF0248

5

IPR007548

7,548

Protein of unknown function DUF505

DUF505

Family

102

false

This is a family of uncharacterised prokaryotic proteins.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04458", "PIRSF029056" ]

[ "DUF505", "DUF505" ]

[ 102, 9 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria" ]

[ 34, 68 ]

2

[]

0

true

Family

Protein of unknown function DUF505

DUF505

2

IPR007549

7,549

Domain of unknown function DUF512

DUF512

Domain

2,296

false

This entry represents a domain found in a group of putative radical SAM proteins mostly from bacteria. It is associated with the N-terminal domain [ ].

[]

0

[ "PFAM" ]

[ "PF04459" ]

[ "DUF512" ]

[ 2296 ]

1

[]

0

[ "9cg1", "9cg2" ]

2

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Paulinella", "unclassified sequences" ]

[ 2144, 30, 5, 117 ]

4

[]

0

true

Domain

Domain of unknown function DUF512

DUF512

3

IPR007553

7,553

2-thiouracil desulfurase

2-thiour_desulf

Family

10,732

false

This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity [ ].

[]

0

[ "PFAM" ]

[ "PF04463" ]

[ "2-thiour_desulf" ]

[ 10732 ]

1

[]

0

[ "6z92", "6z93", "6z94", "6z96", "6zw9" ]

5

[ "PUB00098595" ]

[ "29194984" ]

[ "A gene encoding a DUF523 domain protein is involved in the conversion of 2-thiouracil into uracil." ]

[ 2018 ]

1

[]

[ "IPR017087" ]

0

1

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 162, 10392, 3, 51, 124 ]

5

[]

0

true

Family

2-thiouracil desulfurase

2-thiour_desulf

4

IPR007554

7,554

CDP-glycerol glycerophosphotransferase

Glycerophosphate_synth

Family

16,929

false

Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of Gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(gly...

[ "GO:0047355", "GO:0016020" ]

[ "CDP-glycerol glycerophosphotransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04464" ]

[ "Glyphos_transf" ]

[ 16929 ]

1

[ "EC", "GP", "GP" ]

[ "2.7.8", "GenProp1398", "GenProp1756" ]

[ "EC:2.7.8", "GP:GenProp1398", "GP:GenProp1756" ]

3

[ "3l7i", "3l7j", "3l7k", "3l7l", "3l7m", "8a0c", "8a0m", "8qoy", "8va1" ]

9

[ "PUB00010019", "PUB00083232", "PUB00083233" ]

[ "10648531", "19520862", "21035733" ]

[ "Molecular analysis of the tagF gene, encoding CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase of Staphylococcus epidermidis ATCC 14990.", "The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis.", "Staphylococcus aureus and Baci...

[ 2000, 2009, 2010 ]

3

[]

[ "IPR016886", "IPR016993", "IPR049698", "IPR049700", "IPR049702" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctPAi1", "unclassified sequences" ]

[ 244, 16454, 4, 1, 226 ]

5

[]

0

true

Family

CDP-glycerol glycerophosphotransferase

Glycerophosphate_synth

7

IPR007555

7,555

Domain of unknown function DUF499

DUF499

Domain

1,793

false

This is a family of uncharacterised hypothetical prokaryotic proteins.

[]

0

[ "PFAM" ]

[ "PF04465" ]

[ "DUF499" ]

[ 1793 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 253, 1510, 2, 28 ]

4

[]

0

true

Domain

Domain of unknown function DUF499

DUF499

9

IPR007556

7,556

Protein of unknown function DUF483

DUF483

Family

77

false

This entry represents Uncharacterized protein MTH_236, AF_0426, MJ1106 and other uncharacterised archaeal proteins.

[]

0

[ "PFAM" ]

[ "PF04467" ]

[ "DUF483" ]

[ 77 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria" ]

[ 70, 7 ]

2

[]

0

true

Family

Protein of unknown function DUF483

DUF483

1

IPR007557

7,557

PSP1, C-terminal

PSP1_C

Domain

11,307

false

The yeast polymerase suppressor 1 (PSP1) protein partially suppresses mutations in DNA polymerases alpha and delta [ ]. The C-terminal half of PSP1 contains a domain, which is also found in several hypothetical proteins from both eukaryotic and prokaryotic sources: Crithidia fasciculata RBP45 and RBP33, subunits of the...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04468", "PS51411" ]

[ "PSP1", "PSP1_C" ]

[ 11219, 11200 ]

2

[]

0

[]

0

[ "PUB00010018", "PUB00052611", "PUB00052612", "PUB00075458", "PUB00106189" ]

[ "9529527", "15470247", "12270811", "23490197", "28295778" ]

[ "Suppressors of the temperature sensitivity of DNA polymerase alpha mutations in Saccharomyces cerevisiae.", "Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II.", "Mutation in yaaT leads to significa...

[ 1998, 2004, 2002, 2013, 2017 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8419, 2731, 157 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Domain

PSP1, C-terminal

PSP1_C

4

IPR007560

7,560

Restriction endonuclease type IV, Mrr

Restrct_endonuc_IV_Mrr

Domain

21,447

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0004519", "GO:0009307" ]

[ "DNA binding", "endonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF04471" ]

[ "Mrr_cat" ]

[ 21447 ]

1

[]

0

[ "1y88", "4f0p", "4f0q", "4oc8", "4r28" ]

5

[ "PUB00010098", "PUB00010100", "PUB00035705", "PUB00035707", "PUB00035708" ]

[ "1650347", "11313145", "15121719", "12665693", "16313623" ]

[ "Characterization and expression of the Escherichia coli Mrr restriction system.", "Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs.", "S-Adenosyl-L-methionine-dependent restriction enzymes.", ...

[ 1991, 2001, 2004, 2003, 2005 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "IncN plasmid pKM101", "Viruses", "metagenomes" ]

[ 1184, 19400, 583, 1, 32, 247 ]

6

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Restriction endonuclease type IV, Mrr

Restrct_endonuc_IV_Mrr

4

IPR007561

7,561

Cell division protein SepF/SepF-related

Cell_div_SepF/SepF-rel

Family

12,892

false

This entry represents a cell division protein, designated SepF, which is conserved in Gram-positive bacteria. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation [ , ]. This protein uses an amphipathic helix for membrane binding and polymerises into large r...

[ "GO:0090529" ]

[ "cell septum assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04472" ]

[ "SepF" ]

[ 12892 ]

1

[]

0

[ "3p04", "3zie", "3zig", "3zih", "3zii", "6sat", "6scp", "6scq", "6scs", "7al1", "7al2", "8hzq", "8hzt" ]

13

[ "PUB00043574", "PUB00099723", "PUB00099724", "PUB00099725" ]

[ "16420366", "34103513", "22912848", "24218584" ]

[ "SepF, a novel FtsZ-interacting protein required for a late step in cell division.", "The archaeal protein SepF is essential for cell division in Haloferax volcanii.", "Bacillus subtilis SepF binds to the C-terminus of FtsZ.", "Structural and genetic analyses reveal the protein SepF as a new membrane anchor f...

[ 2006, 2021, 2012, 2013 ]

4

[]

[ "IPR012426", "IPR023052" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 717, 11865, 19, 291 ]

4

[]

0

true

Family

Cell division protein SepF/SepF-related

Cell_div_SepF/SepF-rel

3

IPR007562

7,562

Transglutaminase-like domain

Transglutaminase-like_domain

Domain

415

false

This entry represents a transglutaminase-like domain found in a family of uncharacterised archaeal proteins that had previously been called DUF553 and UPF0252.

[]

0

[ "PFAM" ]

[ "PF04473" ]

[ "DUF553" ]

[ 415 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Geoglobus acetivorans pleomorphic virus 1", "metagenomes" ]

[ 214, 177, 5, 1, 18 ]

5

[]

0

true

Domain

Transglutaminase-like domain

Transglutaminase-like_domain

3

IPR007563

7,563

Protein of unknown function DUF554

DUF554

Family

5,992

false

This is a family of uncharacterised prokaryotic proteins. Multiple predicted transmembrane regions suggest that the protein is membrane associated.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04474", "PTHR36111" ]

[ "DUF554", "" ]

[ 5992, 5911 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 30, 5754, 4, 204 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF554

DUF554

1

IPR007565

7,565

(5-formylfuran-3-yl)methyl phosphate synthase

4HFCP_synth

Family

1,315

false

This entry represents the (5-formylfuran-3-yl)methyl phosphate synthase (also known as 4-HFC-P synthase or MfnB), which has a classical TIM-barrel structure whose biological unit is a homohexamer. It is involved in the production of methanofuran. MfnB from Methanocaldococcus jannaschii catalyzed at least 10 separate ch...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04476", "PIRSF015957" ]

[ "4HFCP_synth", "UCP015957" ]

[ 1315, 1100 ]

2

[ "EC", "METACYC" ]

[ "4.2.3.153", "PWY-5254" ]

[ "EC:4.2.3.153", "METACYC:PWY-5254" ]

2

[ "4rc1", "4u9p" ]

2

[ "PUB00077121" ]

[ "25905665" ]

[ "Mechanism of the Enzymatic Synthesis of 4-(Hydroxymethyl)-2- furancarboxaldehyde-phosphate (4-HFC-P) from Glyceraldehyde-3-phosphate Catalyzed by 4-HFC-P Synthase." ]

[ 2015 ]

1

[]

[ "IPR035081" ]

0

1

0

[ "Archaea", "Bacteria", "Ricinus communis", "ecological metagenomes" ]

[ 273, 997, 1, 44 ]

4

[]

0

true

Family

(5-formylfuran-3-yl)methyl phosphate synthase

4HFCP_synth

7

IPR007566

7,566

Phosphoenolpyruvate carboxylase, archaeal-type

PEP_COase_arc-type

Family

589

false

Phosphoenolpyruvate carboxylase (PEPCase), an enzyme found in all multicellular plants, catalyses the formation of oxaloacetate from phosphoenolpyruvate (PEP) and a hydrocarbonate ion [ ]. This reaction is harnessed by C4 plants to capture and concentrate carbon dioxide into the photosynthetic bundle sheath cells. It a...

[ "GO:0008964", "GO:0006099", "GO:0015977" ]

[ "phosphoenolpyruvate carboxylase activity", "tricarboxylic acid cycle", "carbon fixation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "PFAM", "PIRSF", "NCBIFAM" ]

[ "MF_01904", "PF14010", "PIRSF006677", "TIGR02751" ]

[ "PEPcase_type2", "PEPcase_2", "UCP006677", "PEPCase_arch" ]

[ 406, 589, 514, 558 ]

4

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.1.31", "PWY-1622", "PWY-241", "PWY-5913", "PWY-6142", "PWY-6146", "PWY-6549", "PWY-7115", "PWY-7117", "PWY-7124" ]

[ "EC:4.1.1.31", "METACYC:PWY-1622", "METACYC:PWY-241", "METACYC:PWY-5913", "METACYC:PWY-6142", "METACYC:PWY-6146", "METACYC:PWY-6549", "METACYC:PWY-7115", "METACYC:PWY-7117", "METACYC:PWY-7124" ]

10

[ "3odm" ]

1

[ "PUB00003734", "PUB00003752", "PUB00004559", "PUB00004561" ]

[ "2779518", "1508152", "1421147", "1450389" ]

[ "The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression.", "Homologous genes for the C4 isoform of phosphoenolpyruvate carboxylase in a C3 and a C4 Flaveria species.", "Alfalfa root nodule phosphoenolpyruvate carboxylase: characterization o...

[ 1989, 1992, 1992, 1992 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 273, 288, 2, 26 ]

4

[]

0

true

Family

Phosphoenolpyruvate carboxylase, archaeal-type

PEP_COase_arc-type

7

IPR007567

7,567

Mid2 domain

Mid2_dom

Domain

976

false

This domain is found near the C terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress. The C-terminal cytoplasmic region of Mid2 i...

[]

0

[ "PFAM" ]

[ "PF04478" ]

[ "Mid2" ]

[ 976 ]

1

[]

0

[]

0

[ "PUB00019860" ]

[ "11113201" ]

[ "Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "Staphylococcus" ]

[ 973, 3 ]

2

[ "Arabidopsis thaliana", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2 ]

2

true

Domain

Mid2 domain

Mid2_dom

5

IPR007568

7,568

RTA-like protein

RTA1

Family

21,166

false

This family is comprised of fungal proteins with multiple transmembrane regions. RTA1 ( ) is involved in resistance to 7-aminocholesterol [ ], while RTM1 ( ) confers resistance to an unknown toxic chemical in molasses [ ]. RSB1 is also a member of this family; it is sphingoid long-chain base transporter [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04479", "PTHR31465" ]

[ "RTA1", "" ]

[ 21087, 20843 ]

2

[]

0

[]

0

[ "PUB00010021", "PUB00010022", "PUB00089254" ]

[ "8660468", "7672593", "28175317" ]

[ "Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance.", "RTM1: a member of a new family of telomeric repeated genes in yeast.", "Loop 5 region is important for the activity of the long-chain base transporter Rsb1." ]

[ 1996, 1995, 2017 ]

3

[]

0

null

[ "Eukaryota", "Streptococcus salivarius", "marine metagenome" ]

[ 21164, 1, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 4, 1 ]

3

true

Family

RTA-like protein

RTA1

3

IPR007569

7,569

Domain of unknown function DUF559

DUF559

Domain

16,473

false

This entry represents a domain of unknown function found in Type II nicking enzyme V.HpaIIP from Haemophilus parainfluenzae, an endonuclease that may nick HpaII sequences that contain GT mismatches resulting from m5C-deamination and play a role in the very short patch (VSP) repair process, counteracting mutations [ ]. ...

[]

0

[ "PFAM" ]

[ "PF04480" ]

[ "DUF559" ]

[ 16473 ]

1

[]

0

[ "3hrl", "3r3p" ]

2

[ "PUB00013622", "PUB00022328", "PUB00035701", "PUB00056992" ]

[ "10612397", "12626704", "12067333", "21890897" ]

[ "Recognition of a TG mismatch: the crystal structure of very short patch repair endonuclease in complex with a DNA duplex.", "Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix.", "Cooperation and competition in mismatch ...

[ 1999, 2003, 2002, 2011 ]

4

[]

[ "IPR047216" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 32, 16093, 21, 61, 266 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF559

DUF559

6

IPR007570

7,570

Uncharacterised protein family Ycf23

Uncharacterised_Ycf23

Family

1,158

false

Protein in this entry are of unknown function and are found in cyanobacteria and the chloroplasts of algae. As the family is exclusively found in phototrophic organisms it may play a role in photosynthesis.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04481", "PTHR36895" ]

[ "DUF561", "" ]

[ 1155, 1131 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 373, 785 ]

2

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 17 ]

2

true

Family

Uncharacterised protein family Ycf23

Uncharacterised_Ycf23

9

IPR007572

7,572

Uncharacterised protein family Ycf20

Uncharacterised_Ycf20

Family

2,497

false

This family represents Ycf20, it is found in cyanobacteria and is also encoded in plant and algal chloroplasts; its function is unknown. As the family is exclusively found in phototrophic organisms it may therefore play a role in photosynthesis.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04483", "PTHR33787" ]

[ "DUF565", "" ]

[ 2389, 2273 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 393, 2104 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 14, 12 ]

3

true

Family

Uncharacterised protein family Ycf20

Uncharacterised_Ycf20

5

IPR007574

7,574

Phycobilisome degradation protein NblA

NblA

Family

813

false

In the cyanobacterium Synechococcus species PCC 7942 ( ), nblA triggers degradation of light-harvesting phycobiliproteins in response to deprivation nutrients including nitrogen, phosphorus and sulphur. The mechanism of nblA function is not known, but it has been hypothesised that nblA may act by disrupting phycobiliso...

[]

0

[ "PFAM" ]

[ "PF04485" ]

[ "NblA" ]

[ 813 ]

1

[]

0

[ "1ojh", "2q8v", "2qdo", "3cs5" ]

4

[]

0

[]

0

null

[ "Cyanobacteriota", "Rhodophyta", "Viruses" ]

[ 584, 225, 4 ]

3

[]

0

true

Family

Phycobilisome degradation protein NblA

NblA

2

IPR007575

7,575

SchA/CurD-like domain

SchA_CurD-like

Domain

958

false

Proteins having this domain have been identified mainly in species of the Streptomyces genus. Two of them are known to be part of gene clusters involved in the synthesis of polyketide-based spore pigments, homologous to clusters involved in the synthesis of polyketide antibiotics. Their function is unknown, but they ha...

[]

0

[ "PFAM" ]

[ "PF04486" ]

[ "SchA_CurD" ]

[ 958 ]

1

[]

0

[]

0

[ "PUB00010020" ]

[ "8344517" ]

[ "Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp." ]

[ 1993 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 958 ]

1

[]

0

true

Domain

SchA/CurD-like domain

SchA_CurD-like

8

IPR007576

7,576

CITED

Family

1,950

false

CITED, CBP/p300-interacting transactivator with ED-rich tail, is characterised by a conserved 32-amino acid sequence at the C terminus. CITED protein does not bind DNA directly and is thought to function as a transcriptional co-activator [ ].

[ "GO:0006355", "GO:0005634" ]

[ "regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04487", "PTHR17045" ]

[ "CITED", "" ]

[ 1930, 1911 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1234158", "R-BTA-8866907", "R-BTA-9018519", "R-GGA-8866907", "R-HSA-1234158", "R-HSA-8866906", "R-HSA-8866907", "R-HSA-9018519", "R-HSA-9614657", "R-MMU-1234158", "R-MMU-8866907", "R-MMU-9018519", "R-RNO-8866907" ]

[ "REACTOME:R-BTA-1234158", "REACTOME:R-BTA-8866907", "REACTOME:R-BTA-9018519", "REACTOME:R-GGA-8866907", "REACTOME:R-HSA-1234158", "REACTOME:R-HSA-8866906", "REACTOME:R-HSA-8866907", "REACTOME:R-HSA-9018519", "REACTOME:R-HSA-9614657", "REACTOME:R-MMU-1234158", "REACTOME:R-MMU-8866907", "REACTOM...

13

[ "1p4q", "1r8u", "7lvs" ]

3

[ "PUB00010119" ]

[ "11744733" ]

[ "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2." ]

[ 2002 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1950 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 10, 7, 10 ]

4

true

Family

CITED

6

IPR007577

7,577

Glycosyltransferase, DXD sugar-binding motif

GlycoTrfase_DXD_sugar-bd_CS

Conserved_site

22,566

false

This entry represents those sugar-binding regions of glycosyltransferases that contain a DXD motif. The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleos...

[]

0

[ "PFAM" ]

[ "PF04488" ]

[ "Gly_transf_sug" ]

[ 22566 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1", "R-DME-913709", "R-DME-9840309", "R-HSA-913709", "R-HSA-9840309", "R-MMU-913709", "R-MMU-9840309", "R-RNO-9840309" ]

[ "EC:2.4.1", "REACTOME:R-DME-913709", "REACTOME:R-DME-9840309", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-9840309", "REACTOME:R-MMU-913709", "REACTOME:R-MMU-9840309", "REACTOME:R-RNO-9840309" ]

8

[ "4mix", "8ovs", "8ovt", "8x4j", "8x4k", "8x4m", "9n3s" ]

7

[ "PUB00010023" ]

[ "9653120" ]

[ "Activity of the yeast MNN1 alpha-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)", "Viruses", "metagenomes" ]

[ 4426, 17660, 1, 136, 343 ]

5

[ "Arabidopsis thaliana", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyc...

[ 26, 3, 21, 5, 4, 7, 4, 4, 4, 6 ]

10

true

Conserved_site

Glycosyltransferase, DXD sugar-binding motif

GlycoTrfase_DXD_sugar-bd_CS

8

IPR007578

7,578

Herpesvirus U10

Herpes_U10

Family

123

false

This proteins in this entry belong to the herpesvirus U10 family. Family member Protein UL31 is involved in the inhibition of the host innate immune system. It targets host CGAS, promoting dissociation of DNA from CGAS, thus inhibiting the enzymatic activity of CGAS [ ].

[]

0

[ "PFAM" ]

[ "PF04489" ]

[ "DUF570" ]

[ 123 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[]

0

[ "PUB00091694" ]

[ "29937271" ]

[ "Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion." ]

[ 2018 ]

1

[]

0

null

[ "Herpesvirales", "Homo sapiens" ]

[ 122, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus U10

Herpes_U10

1

IPR007579

7,579

Poxvirus T4 protein, C-terminal

Poxvirus_T4p_C

Domain

88

false

This entry represents the C-terminal domain of T4 protein from Sheeppox virus, Protein OPG195 from Monkeypox virus, and similar sequences from poxvirus. T4 is thought to be retained in the endoplasmic reticulum. M-T4 of myxoma virus ( ) is thought to protect infected lymphocytes from apoptosis and modulate the inflamma...

[]

0

[ "PFAM" ]

[ "PF04490" ]

[ "Pox_T4_C" ]

[ 88 ]

1

[]

0

[ "4hkj" ]

1

[ "PUB00010024", "PUB00103697" ]

[ "10544103", "23209377" ]

[ "Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis.", "Structural mechanism of ER retrieval of MHC class I by cowpox." ]

[ 1999, 2012 ]

2

[]

0

null

[ "Chordopoxvirinae" ]

[ 88 ]

1

[]

0

true

Domain

Poxvirus T4 protein, C-terminal

Poxvirus_T4p_C

5

IPR007580

7,580

Poxvirus T4 protein, N-terminal

Poxvirus_T4p_N

Domain

103

false

This entry represents the N-terminal domain of T4 protein from Sheeppox virus, Protein OPG195 from Monkeypox virus, and similar sequences from poxvirus. T4 protein is thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C-terminal region ( ). M-T4 of myxoma virus ( ...

[]

0

[ "PFAM" ]

[ "PF04491" ]

[ "Pox_T4_N" ]

[ 103 ]

1

[]

0

[ "4hkj" ]

1

[ "PUB00010024", "PUB00103697" ]

[ "10544103", "23209377" ]

[ "Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis.", "Structural mechanism of ER retrieval of MHC class I by cowpox." ]

[ 1999, 2012 ]

2

[]

0

null

[ "Chordopoxvirinae" ]

[ 103 ]

1

[]

0

true

Domain

Poxvirus T4 protein, N-terminal

Poxvirus_T4p_N

6

IPR007581

7,581

Endonuclease V

Endonuclease-V

Family

9,978

false

This entry includes Endonuclease V from bacteria and eukaryotes which cleaves the second phosphodiester bond 3' to a deaminated adenosine (inosine). In bacteria, it is specific for single-stranded DNA, for duplex DNA that contains uracil, or that is damaged [ , ]. Despite being highly conserved, EndoV homologues change...

[ "GO:0004519" ]

[ "endonuclease activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PANTHER", "CDD" ]

[ "MF_00801", "PF04493", "PTHR28511", "cd06559" ]

[ "Endonuclease_5", "Endonuclease_5", "", "Endonuclease_V" ]

[ 6995, 9928, 9162, 8451 ]

4

[ "EC", "REACTOME" ]

[ "3.1.21.7", "R-CEL-446193" ]

[ "EC:3.1.21.7", "REACTOME:R-CEL-446193" ]

2

[ "2w35", "2w36", "3ga2", "3goc", "3hd0", "4b20", "4nsp", "4xpu", "5aoy", "6oze", "6ozf", "6ozg", "6ozh", "6ozi", "6ozj", "6ozk", "6ozl", "6ozm", "6ozn", "6ozo", "6ozp", "6ozq", "6ozr", "6ozs" ]

24

[ "PUB00010026", "PUB00162575", "PUB00162576", "PUB00162577", "PUB00162578", "PUB00162579", "PUB00162580" ]

[ "8990280", "23912683", "23912718", "25195743", "27573237", "31444105", "31703097" ]

[ "nfi, the gene for endonuclease V in Escherichia coli K-12.", "Endonuclease V cleaves at inosines in RNA.", "Human endonuclease V is a ribonuclease specific for inosine-containing RNA.", "Structure of human endonuclease V as an inosine-specific ribonuclease.", "Regulation of Human Endonuclease V Activity an...

[ 1997, 2013, 2013, 2014, 2016, 2019, 2019 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 668, 6052, 3150, 17, 91 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 1, 12, 5, 3, 6, 1, 31 ]

9

true

Family

Endonuclease V

Endonuclease-V

9

IPR007582

7,582

TFIID subunit TAF5, NTD2 domain

TFIID_NTD2

Domain

5,995

false

This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly [ ]. The...

[]

0

[ "PFAM", "CDD" ]

[ "PF04494", "cd08044" ]

[ "TFIID_NTD2", "TAF5_NTD2" ]

[ 5995, 5392 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-674695", "R-CEL-6807505", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-CEL-9907900", "R-DME-674695", "R-DME-6804756", "R-DME-6807505", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-DME-9907900", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172...

[ "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6807505", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-CEL-9907900", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-6807505", "REACTOME:R-DME-73776", "REACTOME:R-DME-7377...

46

[ "2j49", "2j4b", "2nxp", "6f3t", "6hqa", "6mzc", "6mzd", "6mzl", "6mzm", "6t9i", "6t9k", "6tb4", "6tbm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egi", "7egj", "7ena", "7enc", "7ktr", "7kts", "8gxq", "8gxs"...

41

[ "PUB00042067", "PUB00047787", "PUB00079481", "PUB00079482" ]

[ "17227857", "17397863", "10664584", "16206511" ]

[ "Structural analysis and dimerization potential of the human TAF5 subunit of TFIID.", "Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.", "TBP-associated factors (TAFIIs): multiple, selective transcriptional mediato...

[ 2007, 2007, 2000, 2005 ]

4

[]

0

null

[ "Eukaryota", "mine drainage metagenome" ]

[ 5994, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 4, 2, 3, 5, 1, 6, 8, 1, 2, 7 ]

12

true

Domain

TFIID subunit TAF5, NTD2 domain

TFIID_NTD2

3

IPR007583

7,583

GRASP55/65

GRASP55_65

Family

5,460

false

GRASP55 (Golgi reassembly stacking protein of 55kDa) and GRASP65 (a 65kDa) protein are highly homologous. GRASP55 is a component of the Golgi stacking machinery. GRASP65 is an N-ethylmaleimide-sensitive membrane protein required for the stacking of Golgi cisternae in a cell-free system [ ].

[]

0

[ "PANTHER" ]

[ "PTHR12893" ]

[ "" ]

[ 5460 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162658", "R-HSA-204005", "R-HSA-6807878", "R-MMU-162658", "R-MMU-204005", "R-MMU-6807878", "R-RNO-162658", "R-RNO-204005", "R-RNO-6807878", "R-SCE-162658", "R-SCE-204005", "R-SPO-162658", "R-SPO-204005" ]

[ "REACTOME:R-HSA-162658", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-6807878", "REACTOME:R-MMU-162658", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-6807878", "REACTOME:R-RNO-162658", "REACTOME:R-RNO-204005", "REACTOME:R-RNO-6807878", "REACTOME:R-SCE-162658", "REACTOME:R-SCE-204005", "REACTOME:R-SPO-...

13

[ "3rle", "4edj", "4kfv", "4kfw", "4rey", "5gmi", "5gmj", "5gml", "5h3j", "6g8t", "6g8w" ]

11

[ "PUB00010027" ]

[ "10487747" ]

[ "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5460 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 7, 1, 31, 10, 1, 11, 1, 1 ]

9

true

Family

GRASP55/65

GRASP55_65

2

IPR007584

7,584

Herpesvirus UL35

Herpes_UL35

Family

105

false

The small capsomere-interacting protein (SCP, also known as UL35 or VP26) represents a true late gene which encodes a 12kDa capsid protein [ ]. SCP forms a complex with the major capsid protein in the cytoplasm which is translocated to the nucleus. SCP decorates the outer surface of the capsid shell during capsid assem...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04020", "PF04496" ]

[ "HSV_SCP_alphahv", "Herpes_UL35" ]

[ 102, 104 ]

2

[]

0

[ "5zap", "5zz8", "6cgr", "6lgl", "6lgn", "6m6g", "6m6h", "6m6i", "6odm", "7bw6", "7fj1", "7fj3", "8x9x", "8x9y", "8xa3", "9no1" ]

16

[ "PUB00010028", "PUB00084214" ]

[ "1313892", "15117959" ]

[ "Identification and characterization of the herpes simplex virus type 1 virion protein encoded by the UL35 open reading frame.", "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport." ]

[ 1992, 2004 ]

2

[]

0

null

[ "Alphaherpesvirinae" ]

[ 105 ]

1

[]

0

true

Family

Herpesvirus UL35

Herpes_UL35

9

IPR007585

7,585

Poxvirus E2

Poxvirus_E2

Family

177

false

This entry represents Protein E2 from Vaccinia virus, also known as Protein OPG064, and similar sequences from poxvirus. E2 plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. Together with protein OPG056/F12, it forms a complex that interacts with host KLC2 (kinesin light...

[]

0

[ "PIRSF" ]

[ "PIRSF015692" ]

[ "VAC_E2L" ]

[ 177 ]

1

[]

0

[ "7phy" ]

1

[ "PUB00103568", "PUB00103612", "PUB00103613" ]

[ "19207726", "25760349", "35020582" ]

[ "An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection.", "Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex.", "The crystal structure of vaccinia virus protein E2 and perspectives on the pre...

[ 2009, 2015, 2022 ]

3

[ "IPR021155" ]

[]

1

0

1

[ "Poxviridae" ]

[ 177 ]

1

[]

0

true

Family

Poxvirus E2

Poxvirus_E2

4

IPR007586

7,586

Poxvirus VP8/L4R, nucleic acid binding

VP8_pox_nuc-bd

Family

113

false

The 25kDa product of Vaccinia virus gene L4R is also known as VP8. VP8 is found in the cores of Vaccinia virions and is essential for the formation of transcriptionally competent viral particles. It binds both single stranded and double stranded DNA and RNA with similar affinities. Binding is thought to involve coopera...

[ "GO:0005198", "GO:0019028" ]

[ "structural molecule activity", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04498" ]

[ "Pox_VP8_L4R" ]

[ 113 ]

1

[]

0

[]

0

[ "PUB00010030" ]

[ "9321647" ]

[ "Vaccinia virion protein VP8, the 25 kDa product of the L4R gene, binds single-stranded DNA and RNA with similar affinity." ]

[ 1997 ]

1

[]

0

null

[ "Poxviridae" ]

[ 113 ]

1

[]

0

true

Family

Poxvirus VP8/L4R, nucleic acid binding

VP8_pox_nuc-bd

1

IPR007587

7,587

SIT4 phosphatase-associated protein family

SAPS

Family

12,220

false

This entry includes budding yeast Sit4-associated proteins, such as Sap155, Sap185, and Sap190. Sit4 is a phosphatase involved in a variety of processes including transcription, translation, bud formation, glycogen metabolism, monovalent ion homeostasis, H+ transport, and telomere function [ ]. This entry also includes...

[ "GO:0019903" ]

[ "protein phosphatase binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04499", "PTHR12634" ]

[ "SAPS", "" ]

[ 11341, 12060 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-204005", "R-HSA-171319", "R-HSA-204005", "R-MMU-171319", "R-MMU-204005", "R-SCE-204005" ]

[ "REACTOME:R-GGA-204005", "REACTOME:R-HSA-171319", "REACTOME:R-HSA-204005", "REACTOME:R-MMU-171319", "REACTOME:R-MMU-204005", "REACTOME:R-SCE-204005" ]

6

[]

0

[ "PUB00092454" ]

[ "16769727" ]

[ "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota", "Shewanella electrica" ]

[ 12219, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 28, 1, 53, 4, 22, 17, 2, 11, 13, 4, 1, 90 ]

12

true

Family

SIT4 phosphatase-associated protein family

SAPS

1

IPR007588

7,588

Zinc finger, FLYWCH-type

Znf_FLYWCH

Domain

11,282

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[]

0

[ "PFAM" ]

[ "PF04500" ]

[ "FLYWCH" ]

[ 11282 ]

1

[]

0

[ "2rpr" ]

1

[ "PUB00014077", "PUB00019570", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035808", "PUB00035809", "PUB00035811", "PUB00035812", "PUB00035848", "PUB00043274" ]

[ "12665246", "12723696", "17210253", "15963892", "15718139", "10529348", "11361095", "10664601", "10940247", "11179890", "16944302", "18253864" ]

[ "Zinc fingers--folds for many occasions.", "The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on R...

[ 2002, 2003, 2007, 2005, 2005, 1999, 2001, 2000, 2000, 2001, 2006, 2008 ]

12

[]

0

null

[ "Eukaryota", "Lambdina fiscellaria nucleopolyhedrovirus", "Paenibacillus albus" ]

[ 11280, 1, 1 ]

3

[ "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 47, 7, 3, 4 ]

5

true

Domain

Zinc finger, FLYWCH-type

Znf_FLYWCH

7

IPR007589

7,589

Baculovirus major capsid protein VP39

Baculo_VP39

Family

161

false

This family constitutes the 39kDa major capsid protein of the Baculoviridae [ ].

[ "GO:0005198", "GO:0019028" ]

[ "structural molecule activity", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04501" ]

[ "Baculo_VP39" ]

[ 161 ]

1

[]

0

[ "8i8a", "8i8b", "8taf", "8vwh", "8vwi", "8vwj", "9h1s", "9h2a", "9h2b", "9h2j", "9jpr", "9jps", "9jpt", "9k2o" ]

14

[ "PUB00010031" ]

[ "2644736" ]

[ "Nucleotide sequence, transcriptional mapping, and temporal expression of the gene encoding p39, a major structural protein of the multicapsid nuclear polyhedrosis virus of Orgyia pseudotsugata." ]

[ 1989 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 161 ]

1

[]

0

true

Family

Baculovirus major capsid protein VP39

Baculo_VP39

7

IPR007590

7,590

Saf4/Yju2 protein

Saf4/Yju2

Family

10,002

false

This entry includes Probable splicing factor YJU2B (also known as CCDC130) and Splicing factor YJU2 (also known as CCDC94) from humans, Saf4 from fission yeasts and Yju2 from budding yeasts. Saf4 (also known as cwc16) is involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the s...

[ "GO:0000398" ]

[ "mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04502", "PTHR12111" ]

[ "Saf4_Yju2", "" ]

[ 9990, 9725 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-SPO-72163" ]

[ "REACTOME:R-DDI-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-SPO-72163" ]

5

[ "5gmk", "5lj3", "5lj5", "5y88", "5yzg", "6exn", "6j6q", "6zym", "7a5p", "7b9v", "8i0w", "9esi" ]

12

[ "PUB00008533", "PUB00079198", "PUB00094479" ]

[ "11884590", "17515604", "29301961" ]

[ "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.", "A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing...

[ 2002, 2007, 2018 ]

3

[]

[ "IPR043701" ]

0

1

0

[ "Bifidobacterium pullorum subsp. saeculare", "Eukaryota", "bird metagenome" ]

[ 1, 9999, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 26, 2, 3, 2, 10, 5, 2, 8, 11, 1, 2, 11 ]

12

true

Family

Saf4/Yju2 protein

Saf4/Yju2

6

IPR007592

7,592

GLABROUS1 enhancer-binding protein-like

GEBP

Family

4,640

false

This family of plant transcription factors includes GLABROUS1 enhancer-binding protein (GeBP) and GeBP-like proteins, and storekeeper and storekeeper-like (STKL) transcription factors. GeBP and GeBP-like proteins play a redundant role in cytokinin hormone pathway regulation [ ]. Storekeeper was identified as a B-box mo...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR31662" ]

[ "" ]

[ 4640 ]

1

[]

0

[]

0

[ "PUB00081457", "PUB00081459", "PUB00081460" ]

[ "18162594", "27031427", "12028578" ]

[ "GeBP and GeBP-like proteins are noncanonical leucine-zipper transcription factors that regulate cytokinin response in Arabidopsis.", "Regulation of Arabidopsis thaliana plasma membrane glucose-responsive regulator (AtPGR) expression by A. thaliana storekeeper-like transcription factor, AtSTKL, modulates glucose ...

[ 2008, 2016, 2002 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4640 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 78, 48, 83 ]

3

true

Family

GLABROUS1 enhancer-binding protein-like

GEBP

6

IPR007593

7,593

CD225/Dispanin family

CD225/Dispanin_fam

Family

14,259

false

This family represents a set of transmembrane proteins including various interferon-induced transmembrane proteins, synapse differentiation-inducing gene protein 1, and tumor suppressor candidate 5 and homologues. Interferon-induced transmembrane protein 1 (also known as human leukocyte antigen CD225) regulates vesicul...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04505" ]

[ "CD225" ]

[ 14259 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-198933", "R-HSA-909733", "R-MMU-198933", "R-RNO-198933" ]

[ "REACTOME:R-HSA-198933", "REACTOME:R-HSA-909733", "REACTOME:R-MMU-198933", "REACTOME:R-RNO-198933" ]

4

[]

0

[ "PUB00010032", "PUB00099674", "PUB00099675" ]

[ "7559564", "22363774", "33518406" ]

[ "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.", "The dispanins: a novel gene family of ancient origin that contains 14 human members.", "CD225 Proteins: A Family Portrait of Fusion Regulators." ]

[ 1995, 2012, 2021 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2193, 12035, 31 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 31, 62, 32, 47 ]

4

true

Family

CD225/Dispanin family

CD225/Dispanin_fam

1

IPR007594

7,594

RFT1

Family

5,270

false

This entry represents the Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1, and related proteins, requited for the translocation of lipid-linked oligosaccharides across the ER membrane [ ]. Rft1 may have a critical accessory role in translocating Man(5)GlcNAc(2)-PP-Dol in vivo [ ]. Asymmetric lipid distribution i...

[ "GO:0006488", "GO:0016020" ]

[ "dolichol-linked oligosaccharide biosynthetic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04506", "PTHR13117" ]

[ "Rft-1", "" ]

[ 5259, 5177 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-446193", "R-HSA-4570571" ]

[ "REACTOME:R-HSA-446193", "REACTOME:R-HSA-4570571" ]

2

[]

0

[ "PUB00016717", "PUB00128045" ]

[ "11807558", "18668045" ]

[ "Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.", "Does Rft1 flip an N-glycan lipid precursor?" ]

[ 2002, 2008 ]

2

[]

0

null

[ "Eukaryota", "Streptococcus cristatus" ]

[ 5269, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 1, 7, 4, 1, 5, 5, 1, 1, 8 ]

12

true

Family

RFT1

8

IPR007595

7,595

Csa family

Csa

Family

861

false

This family contains several uncharacterised proteins mostly from staphylococcal. These proteins have been called conserved staphylococcal antigens (Csa) [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04507", "TIGR01742" ]

[ "DUF576", "SA_tandem_lipo" ]

[ 861, 747 ]

2

[]

0

[ "4big", "4bih", "4eg9", "4egd" ]

4

[ "PUB00081214" ]

[ "23895222" ]

[ "Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 859, 2 ]

2

[]

0

true

Family

Csa family

Csa

5

IPR007596

7,596

Viral A-type inclusion protein repeat

Pox_A_type_inc

Repeat

336

false

The repeat is found in the A-type inclusion protein of the Poxvirus family [ ].

[ "GO:0016032" ]

[ "viral process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04508" ]

[ "Pox_A_type_inc" ]

[ 336 ]

1

[]

0

[]

0

[ "PUB00010033" ]

[ "2826668" ]

[ "Cloning and characterization of the gene encoding the major protein of the A-type inclusion body of cowpox virus." ]

[ 1988 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus barophilus", "Viruses", "metagenomes" ]

[ 16, 59, 1, 257, 3 ]

5

[]

0

true

Repeat

Viral A-type inclusion protein repeat

Pox_A_type_inc

2

IPR007597

7,597

CheC-like protein

CheC

Domain

6,660

false

The precise function of these proteins is unclear, but some of them are involved in flagella motor switch [ ]. The region represented in this entry is found in the CheC, CheX, CheA and FliY proteins. In some cases, this region is repeated in multiple copies.

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04509" ]

[ "CheC" ]

[ 6660 ]

1

[]

0

[ "1xkr", "2f9z", "4hyn" ]

3

[ "PUB00010034" ]

[ "11722727" ]

[ "CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 806, 5792, 2, 60 ]

4

[]

0

true

Domain

CheC-like protein

CheC

9

IPR007598

7,598

Domain of unknown function DUF577

DUF577

Domain

370

false

This domain is found in Arabidopsis thaliana (Mouse-ear cress) putative proteins which are specifically expressed during meiosis [ ]. Many of these members contain a repeated region.

[]

0

[ "PFAM" ]

[ "PF04510" ]

[ "DUF577" ]

[ 370 ]

1

[]

0

[]

0

[ "PUB00097819" ]

[ "25653662" ]

[ "Analysis of Arabidopsis floral transcriptome: detection of new florally expressed genes and expansion of Brassicaceae-specific gene families." ]

[ 2014 ]

1

[]

0

null

[ "rosids" ]

[ 370 ]

1

[ "Arabidopsis thaliana" ]

[ 76 ]

1

true

Domain

Domain of unknown function DUF577

DUF577

9

IPR007599

7,599

Derlin

DER1

Family

11,813

false

The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae (Baker's yeast) contains a proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For examination of the components involved in this degradation process, mutants were isolated. They could be divided into four complementat...

[]

0

[ "PFAM" ]

[ "PF04511" ]

[ "DER1" ]

[ 11813 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-382556", "R-BTA-532668", "R-CEL-382556", "R-CEL-532668", "R-CEL-5358346", "R-DDI-5358346", "R-DME-382556", "R-DME-532668", "R-HSA-382556", "R-HSA-532668", "R-HSA-5358346", "R-HSA-5362768", "R-HSA-5678895", "R-HSA-8866654", "R-HSA-901032", "R-MMU-382556", "R-MMU-532668", "R-M...

[ "REACTOME:R-BTA-382556", "REACTOME:R-BTA-532668", "REACTOME:R-CEL-382556", "REACTOME:R-CEL-532668", "REACTOME:R-CEL-5358346", "REACTOME:R-DDI-5358346", "REACTOME:R-DME-382556", "REACTOME:R-DME-532668", "REACTOME:R-HSA-382556", "REACTOME:R-HSA-532668", "REACTOME:R-HSA-5358346", "REACTOME:R-HSA-...

19

[ "6vjz", "6vk0", "7czb", "7y4w", "7y53", "7y59", "9llk" ]

7

[ "PUB00010035" ]

[ "8631297" ]

[ "Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 13, 11800 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 3, 3, 13, 8, 3, 4, 17, 2, 2, 27 ]

12

true

Family

Derlin

DER1

6

IPR007600

7,600

Baculovirus polyhedron envelope protein PEP, N-terminal

Baculo_PEP_N

Domain

232

false

Polyhedra are large crystalline occlusion bodies containing nucleopolyhedrovirus virions, and surrounded by an electron-dense structure called the polyhedron envelope or polyhedron calyx. The polyhedron envelope (associated) protein PEP is thought to be an integral part of the polyhedron envelope. PEP is concentrated a...

[ "GO:0005198", "GO:0019028", "GO:0019031" ]

[ "structural molecule activity", "viral capsid", "viral envelope" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04512" ]

[ "Baculo_PEP_N" ]

[ 232 ]

1

[]

0

[ "4ye7" ]

1

[ "PUB00010036" ]

[ "8176372" ]

[ "Orgyia pseudotsugata baculovirus p10 and polyhedron envelope protein genes: analysis of their relative expression levels and role in polyhedron structure." ]

[ 1994 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 232 ]

1

[]

0

true

Domain

Baculovirus polyhedron envelope protein PEP, N-terminal

Baculo_PEP_N

3

IPR007601

7,601

Baculovirus polyhedron envelope protein PEP, C-terminal

Baculo_PEP_C

Domain

176

false

Polyhedra are large crystalline occlusion bodies containing nucleopolyhedrovirus virions, and surrounded by an electron-dense structure called the polyhedron envelope or polyhedron calyx. The polyhedron envelope (associated) protein PEP is thought to be an integral part of the polyhedron envelope. PEP is concentrated a...

[ "GO:0005198", "GO:0019028", "GO:0019031" ]

[ "structural molecule activity", "viral capsid", "viral envelope" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04513" ]

[ "Baculo_PEP_C" ]

[ 176 ]

1

[]

0

[]

0

[ "PUB00010036" ]

[ "8176372" ]

[ "Orgyia pseudotsugata baculovirus p10 and polyhedron envelope protein genes: analysis of their relative expression levels and role in polyhedron structure." ]

[ 1994 ]

1

[]

0

null

[ "Bacillati", "Viruses" ]

[ 20, 156 ]

2

[]

0

true

Domain

Baculovirus polyhedron envelope protein PEP, C-terminal

Baculo_PEP_C

9

IPR007602

7,602

Bluetongue virus nonstructural protein NS2

BTV_NS2

Family

782

false

This family includes NS2 proteins from other members of the Orbivirus genus. NS2 is a non-specific single-stranded RNA-binding protein that forms large homomultimers and accumulates in viral inclusion bodies of infected cells. Three RNA-binding regions have been identified in Bluetongue virus 17 ( ) at residues 2-11, 1...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04514" ]

[ "BTV_NS2" ]

[ 782 ]

1

[ "GP" ]

[ "GenProp1006" ]

[ "GP:GenProp1006" ]

1

[ "1uty" ]

1

[ "PUB00010037", "PUB00010102" ]

[ "11752140", "11162836" ]

[ "Localization of the single-stranded RNA-binding domains of bluetongue virus nonstructural protein NS2.", "Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Riboviria" ]

[ 782 ]

1

[]

0

true

Family

Bluetongue virus nonstructural protein NS2

BTV_NS2

3

IPR007603

7,603

Choline transporter-like

Choline_transptr-like

Family

21,422

false

This entry includes a group of choline transporter-like protein, including SLC44A1/2/3/4/5 from humans, Pns1 from budding yeasts, and Ctl1 from fission yeasts [ ]. In humans, mutations of this family of proteins have been linked to several human diseases [ ].

[ "GO:0022857", "GO:0055085" ]

[ "transmembrane transporter activity", "transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04515", "PTHR12385" ]

[ "Choline_transpo", "" ]

[ 20952, 20955 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1483191", "R-BTA-425366", "R-BTA-6798695", "R-CEL-1483191", "R-CEL-425366", "R-CEL-6798695", "R-DDI-1483191", "R-DDI-425366", "R-DDI-6798163", "R-DDI-6798695", "R-DME-1483191", "R-DME-425366", "R-DME-6798163", "R-DME-6798695", "R-DRE-1483191", "R-DRE-425366", "R-DRE-6798695", ...

[ "REACTOME:R-BTA-1483191", "REACTOME:R-BTA-425366", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-1483191", "REACTOME:R-CEL-425366", "REACTOME:R-CEL-6798695", "REACTOME:R-DDI-1483191", "REACTOME:R-DDI-425366", "REACTOME:R-DDI-6798163", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-1483191", "REACTOME:R...

34

[ "7wwb", "9f63", "9qu3" ]

3

[ "PUB00053886", "PUB00095102", "PUB00095103", "PUB00095104" ]

[ "15002745", "19357133", "22483272", "23506897" ]

[ "Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport.", "The solute carrier 44A1 is a mitochondrial protein and mediates choline transport.", "The ubiquitous choline transporter SLC44A1.", "The choline transporter-like family SLC44: properties and roles in human diseases." ]

[ 2004, 2009, 2012, 2013 ]

4

[]

0

null

[ "Candidatus Heimdallarchaeum", "Candidatus Methanofishera endochildressiae", "Eukaryota", "marine sediment metagenome" ]

[ 2, 1, 21418, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 38, 1, 50, 6, 31, 17, 2, 16, 33, 1, 1, 24 ]

12

true

Family

Choline transporter-like

Choline_transptr-like

9

IPR007604

7,604

CP2 transcription factor

CP2

Domain

11,963

false

This entry represents a domain found in animal and fungal Grh/CP2 transcription factors (TFs), key regulators of epithelial differentiation, organ development and skin barrier formation. The Grh/CP2 family of TFs comprises two distinct divisions, CP2 (CCAAT box-binding protein 2) and Grh (grainyhead). Proteins of the C...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04516", "PS51968" ]

[ "CP2", "GRH_CP2_DB" ]

[ 11845, 11931 ]

2

[ "REACTOME" ]

[ "R-HSA-1989781" ]

[ "REACTOME:R-HSA-1989781" ]

1

[ "5mpf", "5mph", "5mpi", "5mr7", "8y7v" ]

5

[ "PUB00090637", "PUB00100931", "PUB00100932" ]

[ "29309642", "22305158", "22590528" ]

[ "Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.", "Grainy head and its target genes in epithelial morphogenesis and wound healing.", "The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers." ]

[ 2018, 2012, 2012 ]

3

[]

0

null

[ "Eukaryota" ]

[ 11963 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 18, 5, 17, 15, 2, 18 ]

7

true

Domain

CP2 transcription factor

CP2

3

IPR007605

7,605

Microvirus lysis protein (E)

Micrvir_lysisE

Family

110

false

E protein causes host cell lysis by inhibiting MraY, a peptidoglycan biosynthesis enzyme. This leads to cell wall failure at septation [ ]. The N-terminal transmembrane region matches the signal peptide model and must be omitted from the family.

[ "GO:0004857" ]

[ "enzyme inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04517" ]

[ "Microvir_lysis" ]

[ 110 ]

1

[]

0

[ "8g01", "8g02" ]

2

[ "PUB00010039" ]

[ "12100551" ]

[ "The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Bullavirinae", "Methanoculleus chikugoensis" ]

[ 3, 106, 1 ]

3

[]

0

true

Family

Microvirus lysis protein (E)

Micrvir_lysisE

1

IPR007606

7,606

Type III secretion system effector

T3SS_effector

Family

148

false

This is a family of Chlamydial effector proteins which are secreted by the type III secretion system [ , ]. The precise function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF04518" ]

[ "Effector_1" ]

[ 148 ]

1

[]

0

[]

0

[ "PUB00057488", "PUB00057489" ]

[ "19682078", "21078856" ]

[ "Identification of Chlamydia trachomatis CT621, a protein delivered through the type III secretion system to the host cell cytoplasm and nucleus.", "Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae." ]

[ 2009, 2011 ]

2

[]

0

null

[ "Plasmodium knowlesi", "Pseudomonadati" ]

[ 3, 145 ]

2

[]

0

true

Family

Type III secretion system effector

T3SS_effector

7

IPR007607

7,607

Bactofilin A/B

BacA/B

Family

13,124

false

This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria, such as BacP, BacN and BacO from Myxococcus xanthus, which are non-essential components of the chromosome segregation machinery [ ]. These proteins position the ParA-ParB-par...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04519", "PTHR35024" ]

[ "Bactofilin", "" ]

[ 12969, 12195 ]

2

[]

0

[ "2n3d", "6ria", "6rib" ]

3

[ "PUB00086465", "PUB00153757" ]

[ "19959992", "29180656" ]

[ "Bactofilins, a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus.", "Bactofilin-mediated organization of the ParABS chromosome segregation system in Myxococcus xanthus." ]

[ 2010, 2017 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 528, 12110, 159, 4, 323 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bactofilin A/B

BacA/B

8

IPR007608

7,608

Senescence regulator S40

Senescence_reg_S40

Family

6,572

false

Proteins in this family include AtS40-3 from Arabidopsis thaliana and similar sequences from plants. AtS40-3 is induced during senescence and is also regulated in response to dark treatment, ABA, salicylic acid and pathogen attack [ ]. It also affects the natural variation of cyst nematodes sex ratio and susceptibility...

[]

0

[ "PFAM" ]

[ "PF04520" ]

[ "Senescence_reg" ]

[ 6572 ]

1

[]

0

[]

0

[ "PUB00057491", "PUB00057492", "PUB00103614" ]

[ "12427984", "20238146", "29378065" ]

[ "A novel nucleus-targeted protein is expressed in barley leaves during senescence and pathogen infection.", "Nuclear targeted AtS40 modulates senescence associated gene expression in Arabidopsis thaliana during natural development and in darkness.", "Genome-wide association study uncovers a novel QTL allele of ...

[ 2002, 2010, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6572 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 52, 48, 57 ]

3

true

Family

Senescence regulator S40

Senescence_reg_S40

1

IPR007609

7,609

ssRNA positive strand viral 18kDa cysteine-rich protein

Viral_P18

Family

30

false

This family represents the 18kDa cysteine-rich protein from ssRNA positive strand viruses. This entry includes Suppressor of RNA silencing . This protein is a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-sp...

[]

0

[ "PFAM" ]

[ "PF04521" ]

[ "Viral_P18" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00151925" ]

[ "15740624" ]

[ "Soilborne wheat mosaic virus (SBWMV) 19K protein belongs to a class of cysteine rich proteins that suppress RNA silencing." ]

[ 2005 ]

1

[]

[ "IPR016567" ]

0

1

0

[ "Virgaviridae" ]

[ 30 ]

1

[]

0

true

Family

ssRNA positive strand viral 18kDa cysteine-rich protein

Viral_P18

2

IPR007610

7,610

Broad bean mottle virus, Gp1, N-terminal

BBMV_Gp1_N

Domain

26

false

This region represents the N-termini of Broad bean mottle virus, Gp1 (2a protein), and is always found N-terminal to a predicted RNA dependent RNA polymerase region ( ).

[ "GO:0003723", "GO:0003968", "GO:0006351" ]

[ "RNA binding", "RNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF04522" ]

[ "BBMV_Gp1_N" ]

[ 26 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[]

0

[]

0

[]

0

null

[ "Bromoviridae" ]

[ 26 ]

1

[]

0

true

Domain

Broad bean mottle virus, Gp1, N-terminal

BBMV_Gp1_N

2

IPR007611

7,611

Herpesvirus tegument protein U30

Herpes_U30

Family

438

false

This family is named after the human herpesvirus protein, but has been characterised in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86. A UL4...

[ "GO:0019068" ]

[ "virion assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04523" ]

[ "Herpes_U30" ]

[ 438 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "8qln", "8tep" ]

2

[ "PUB00010038" ]

[ "11773380" ]

[ "Human cytomegalovirus UL47 tegument protein functions after entry and before immediate-early gene expression." ]

[ 2002 ]

1

[ "IPR034738" ]

[]

1

0

1

[ "Gammaproteobacteria", "Herpesvirales", "Homo sapiens" ]

[ 2, 435, 1 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus tegument protein U30

Herpes_U30

5

IPR007612

7,612

LURP-one-related

LOR

Family

17,502

false

The structure of protein LURP-one-related 15 (At5g01750) has been solved. It comprises a 12-stranded β-barrel with a central C-terminal α-helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein [ ]. In plants LURP1 plays a role in defense agains...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04525", "PTHR31087" ]

[ "LOR", "" ]

[ 17488, 10815 ]

2

[]

0

[ "1zxu", "2q4m" ]

2

[ "PUB00057493", "PUB00057494" ]

[ "19010806", "18346188" ]

[ "Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors.", "The oomycete response gene LURP1 is required for defense against Hyaloperonospora parasitica in Arabidopsis thaliana." ]

[ 2009, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 364, 4576, 12510, 52 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 76, 61, 82 ]

3

true

Family

LURP-one-related

LOR

9

IPR007614

7,614

Retinin-like protein

Retinin_C

Family

819

false

This entry consists of a number of Drosophila proteins which share a conserved C-terminal region related to that of the fly Retinin protein.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04527", "PTHR34931" ]

[ "Retinin_C", "" ]

[ 672, 759 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pterygota" ]

[ 819 ]

1

[ "Drosophila melanogaster" ]

[ 16 ]

1

true

Family

Retinin-like protein

Retinin_C

4

IPR007615

7,615

Adenovirus E4 30/34kDa protein

Adenovirus_E4_30/34

Family

329

false

This entry describes early region 4 open reading frame 3 (E4 ORF3) proteins, including E4 30k, 31k, 33k and 34k proteins. Adenoviruses E4 is essential for DNA replication and late protein synthesis [ ]. The adenovirus E4 ORF3 protein is required for viral DNA replication during the interferon (IFN)-induced antiviral st...

[]

0

[ "PFAM" ]

[ "PF04528" ]

[ "Adeno_E4_34" ]

[ 329 ]

1

[]

0

[]

0

[ "PUB00043450", "PUB00043451", "PUB00043452", "PUB00043453", "PUB00043454" ]

[ "18562516", "18480450", "17287283", "15890904", "10747932" ]

[ "Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.", "Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.", "The adenovirus E4 ORF3 protein binds and reorganizes the TRIM...

[ 2008, 2008, 2007, 2005, 2000 ]

5

[]

0

null

[ "Adenoviridae" ]

[ 329 ]

1

[]

0

true

Family

Adenovirus E4 30/34kDa protein

Adenovirus_E4_30/34

5

IPR007616

7,616

Herpesvirus U59/UL88

Herpes_U59/UL88

Family

113

false

The proteins in this family have no known function. Cytomegalovirus UL88 is also a member of this family.

[]

0

[ "PFAM" ]

[ "PF04529" ]

[ "Herpes_U59" ]

[ 113 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[]

0

[]

0

[]

0

null

[ "Betaherpesvirinae", "Cytophagales", "Homo sapiens" ]

[ 110, 2, 1 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus U59/UL88

Herpes_U59/UL88

7

IPR007617

7,617

Viral beta C/D-like

Viral_beta_CD

Family

60

false

This is a family of ssRNA positive-strand viral proteins. Conserved region is found in the Beta C and Beta D transcripts.

[]

0

[ "PFAM" ]

[ "PF04530" ]

[ "Viral_Beta_CD" ]

[ 60 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Virgaviridae" ]

[ 60 ]

1

[]

0

true

Family

Viral beta C/D-like

Viral_beta_CD

2

IPR007618

7,618

Herpesvirus UL87, N-terminal

Herpes_UL87_N

Domain

160

false

This domain is found at the N termini of some human herpesvirus U58 proteins, and some cytomegalovirus UL87 proteins. This region is always found N-terminal to the UL87 ( ), which has no known function.

[]

0

[ "PFAM" ]

[ "PF04532" ]

[ "DUF587" ]

[ 160 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[]

0

[]

0

[]

0

null

[ "Betaherpesvirinae", "Homo sapiens" ]

[ 159, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Herpesvirus UL87, N-terminal

Herpes_UL87_N

9