LiteFold/InterPro · Datasets at Hugging Face

IPR007737

7,737

Mga helix-turn-helix domain

Mga_HTH

Domain

15,683

false

This domain is found in a group of positive transcriptional regulators, such as M regulator protein trans-acting positive regulator (Mga), a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [ ]. This domain i...

[]

0

[ "PFAM" ]

[ "PF05043" ]

[ "Mga" ]

[ 15683 ]

1

[]

0

[ "3sqn", "4r6i", "5way", "9atx" ]

4

[ "PUB00010185", "PUB00012972", "PUB00055459" ]

[ "11952907", "11988525", "12897001" ]

[ "Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus.", "Group A streptococcal RofA-type global regulators exhibit a strain-specific genomic presence and regulation pattern.", "Mannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assi...

[ 2002, 2002, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 15656, 9, 2, 16 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Mga helix-turn-helix domain

Mga_HTH

2

IPR007739

7,739

Rhamnan synthesis F-like domain

RgpF-like

Domain

3,143

false

This domain is found in a group of proteins which are related to the Streptococcal rhamnose-glucose polysaccharide assembly protein (RgpF), including Virulence protein VirA and Uncharacterized protein WxcX. In some members, this entry represents the C-terminal domain. Rhamnan backbones are found in several O-polysaccha...

[]

0

[ "PFAM" ]

[ "PF05045" ]

[ "RgpF" ]

[ 3143 ]

1

[]

0

[]

0

[ "PUB00010216" ]

[ "12010977" ]

[ "Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanospirillum hungatei", "Viruses", "metagenomes" ]

[ 3035, 25, 1, 10, 72 ]

5

[]

0

true

Domain

Rhamnan synthesis F-like domain

RgpF-like

5

IPR007740

7,740

Large ribosomal subunit protein mL49

Ribosomal_mL49

Family

3,096

false

This entry represents the large ribosomal subunit protein mL49. This family of proteins has been identified as part of the mitochondrial large ribosomal subunit in Saccharomyces cerevisiae [ ]. In yeast , this protein was previously known as IMG2 and in mammals as MRPL49. Ribosomes are the particles that catalyse mRNA-...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF05046", "PTHR13477" ]

[ "Img2", "" ]

[ 3010, 2992 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOM...

13

[ "3j6b", "3j7y", "3j9m", "4ce4", "4v1a", "5aj4", "5mrc", "5mre", "5mrf", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6z1p", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc"...

103

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00010175" ]

[ "11297922", "11290319", "11114498", "12392552" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." ]

[ 2001, 2001, 2000, 2002 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3096 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 3, 5, 3, 1, 3, 1, 1 ]

9

true

Family

Large ribosomal subunit protein mL49

Ribosomal_mL49

6

IPR007741

7,741

Ribosomal protein/NADH dehydrogenase domain

Ribosomal_mL43/mS25/NADH_DH

Domain

10,653

false

Proteins containing this domain are located in the mitochondrion and include large ribosomal subunit protein mL43 (known as MRPL51) and mL61 (MRP49), and small ribosomal subunit protein mS25 (S25). This domain is also found in mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) . It is not known whether all...

[]

0

[ "PFAM", "SMART" ]

[ "PF05047", "SM00916" ]

[ "L51_S25_CI-B8", "L51_S25_CI-B8" ]

[ 10241, 10315 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-BTA-9937383", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-611105", "R-HSA-6799198...

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME...

28

[ "1s3a", "3j6b", "3j7y", "3j9m", "3jd5", "4v1a", "5aj3", "5aj4", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5mrc", "5mre", "5mrf", "5o31", "5ool", "5oom", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gaw", "6gaz", "6gb2", "6gcs", "6hiv", "6hix"...

419

[]

0

[]

0

null

[ "Eukaryota", "Solihabitans fulvus" ]

[ 10652, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 3, 3, 3, 13, 7, 3, 6, 9, 2, 1, 14 ]

12

true

Domain

Ribosomal protein/NADH dehydrogenase domain

Ribosomal_mL43/mS25/NADH_DH

7

IPR007742

7,742

Periplasmic copper-binding protein NosD-like, beta helix domain

NosD_dom

Domain

9,934

false

This entry represents a parallel β helix domain found in several proteins, including NosD. NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ) [ ].

[]

0

[ "PFAM" ]

[ "PF05048" ]

[ "NosD" ]

[ 9934 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8951664", "R-HSA-983168", "R-MMU-8951664", "R-MMU-983168" ]

[ "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-8951664", "REACTOME:R-MMU-983168" ]

4

[ "7o0y", "7o10", "7o11", "7o12", "7o13", "7o14", "7o15", "7o16", "7o17", "7osf", "7osg", "7osh", "7osi", "7osj", "7qba", "7znq" ]

16

[ "PUB00010194" ]

[ "8626275" ]

[ "Identification and analysis of the dissimilatory nitrous oxide reduction genes, nosRZDFY, of Rhizobium meliloti." ]

[ 1996 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2354, 5879, 1171, 23, 507 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4, 3, 6 ]

5

true

Domain

Periplasmic copper-binding protein NosD-like, beta helix domain

NosD_dom

8

IPR007743

7,743

Immunity-related GTPases-like

Immunity-related_GTPase-like

Family

4,990

false

This entry represents a group of immunity-related GTPase-like proteins, including interferon-inducible GTPase from mammals. It also includes some uncharacterised proteins from bacteria, fungi and invertebrates. These proteins adopt an α/β fold with a Ras-like topology [ ].

[ "GO:0005525", "GO:0016020" ]

[ "GTP binding", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05049" ]

[ "IIGP" ]

[ 4990 ]

1

[ "EC" ]

[ "3.6.5.-" ]

[ "EC:3.6.5.-" ]

1

[ "1tpz", "1tq2", "1tq4", "1tq6", "1tqd", "4lv5", "4lv8", "5fph", "7c3k", "7ves", "7vex", "8h4m", "8h4o", "8jqy", "8jqz" ]

15

[ "PUB00010174", "PUB00031535" ]

[ "11907101", "15350217" ]

[ "The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.", "Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 67, 4921, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 25, 6, 54, 33 ]

6

true

Family

Immunity-related GTPases-like

Immunity-related_GTPase-like

3

IPR007745

7,745

Cytochrome c oxidase copper chaperone

Cyt_c_oxidase_Cu-chaperone

Family

3,607

false

Cox17p is essential for the assembly of functional cytochrome c oxidase (CCO). Binds and delivers two copper ions to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2) [ , ].

[ "GO:0005507", "GO:0016531", "GO:0005758" ]

[ "copper ion binding", "copper chaperone activity", "mitochondrial intermembrane space" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF05051", "PTHR16719" ]

[ "COX17", "" ]

[ 3606, 3341 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-9864848", "R-HSA-1268020", "R-HSA-9864848", "R-MMU-9864848" ]

[ "REACTOME:R-CFA-9864848", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

4

[ "1u96", "1u97", "1z2g", "2l0y", "2lgq", "2rn9", "2rnb", "8iuf", "8j9h", "8j9i", "8j9j" ]

11

[ "PUB00010145", "PUB00095325" ]

[ "12370308", "19393246" ]

[ "Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.", "Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase." ]

[ 2002, 2009 ]

2

[]

0

null

[ "Eukaryota", "Sodaliphilus pleomorphus" ]

[ 3606, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 1, 3, 3, 1, 4, 2, 1, 1, 4 ]

12

true

Family

Cytochrome c oxidase copper chaperone

Cyt_c_oxidase_Cu-chaperone

9

IPR007746

7,746

Broad mercury transporter MerE

MerE

Family

747

false

The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon often located on plasmids or transposons [ , ]. It has been suggested that MerE is a broad mercury transporter mediating transport across the bacterial membrane [ ].

[ "GO:0015097", "GO:0015694", "GO:0016020" ]

[ "mercury ion transmembrane transporter activity", "mercury ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05052" ]

[ "MerE" ]

[ 747 ]

1

[]

0

[]

0

[ "PUB00010524", "PUB00010525", "PUB00053838" ]

[ "9479042", "11763242", "19265693" ]

[ "Two aberrant mercury resistance transposons in the Pseudomonas stutzeri plasmid pPB.", "Mercury resistance transposons of gram-negative environmental bacteria and their classification.", "The MerE protein encoded by transposon Tn21 is a broad mercury transporter in Escherichia coli." ]

[ 1998, 2001, 2009 ]

3

[]

0

null

[ "Bacteria", "Rhizopus delemar", "ecological metagenomes", "plasmids" ]

[ 740, 1, 3, 3 ]

4

[]

0

true

Family

Broad mercury transporter MerE

MerE

4

IPR007747

7,747

Menin

Family

1,457

false

The tumour suppressor gene MEN1 is mutated in patients with a dominantly inherited tumour syndrome, multiple endocrine neoplasia type 1 (MEN1) [ ]. The MEN1 gene encodes a protein known as Menin, which is located predominantly in the nucleus. Menin has been shown to interact with the mixed lineage leukemia (MLL) protei...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "CDD" ]

[ "PF05053", "PTHR12693", "cd14456" ]

[ "Menin", "", "Menin" ]

[ 1454, 1449, 1169 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2067", "R-BTA-201722", "R-BTA-2173796", "R-BTA-381426", "R-BTA-5626467", "R-BTA-8957275", "R-BTA-9772755", "R-CFA-201722", "R-CFA-2173796", "R-CFA-381426", "R-CFA-8957275", "R-CFA-9772755", "R-HSA-201722", "R-HSA-2173796", "R-HSA-3769402", "R-HSA-381426", "R-HSA-5626467", "...

[ "GP:GenProp2067", "REACTOME:R-BTA-201722", "REACTOME:R-BTA-2173796", "REACTOME:R-BTA-381426", "REACTOME:R-BTA-5626467", "REACTOME:R-BTA-8957275", "REACTOME:R-BTA-9772755", "REACTOME:R-CFA-201722", "REACTOME:R-CFA-2173796", "REACTOME:R-CFA-381426", "REACTOME:R-CFA-8957275", "REACTOME:R-CFA-9772...

29

[ "3re2", "3u84", "3u85", "3u86", "3u88", "4gpq", "4gq3", "4gq4", "4gq6", "4i80", "4og3", "4og4", "4og5", "4og6", "4og7", "4og8", "4x5y", "4x5z", "5db0", "5db1", "5db2", "5db3", "5dd9", "5dda", "5ddb", "5ddc", "5ddd", "5dde", "5ddf", "6b41", "6bxh", "6bxy"...

61

[ "PUB00010184", "PUB00078407" ]

[ "12145286", "21740816" ]

[ "Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23.", "Menin expression is regulated by transforming growth factor beta signaling in leukemia cells." ]

[ 2002, 2011 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 1456, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 12, 8, 4 ]

5

true

Family

Menin

9

IPR007748

7,748

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf109

AcMNPV_Orf109

Family

144

false

This entry includes protein AC109 from Autographa californica nuclear polyhedrosis virus (AcMNPV). The gene (Orf1090) is essential and transcribed late in virus assembly, and protein AC109 has been shown to be important for the transport of the budded virion to the host nucleus. In mutants lacking the AC109 gene, virio...

[]

0

[ "PFAM" ]

[ "PF05054" ]

[ "AcMNPV_Ac109" ]

[ 144 ]

1

[]

0

[ "8i8b", "8vwi", "8vwj", "9h2a", "9h2b", "9h2j" ]

6

[ "PUB00082303", "PUB00082304" ]

[ "23049963", "23149091" ]

[ "AcMNPV core gene ac109 is required for budded virion transport to the nucleus and for occlusion of viral progeny.", "Autographa californica M nucleopolyhedrovirus open reading frame 109 affects infectious budded virus production and nucleocapsid envelopment in the nucleus of cells." ]

[ 2012, 2013 ]

2

[]

0

null

[ "Baculoviridae" ]

[ 144 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf109

AcMNPV_Orf109

6

IPR007749

7,749

Protein of unknown function DUF677

DUF677

Family

4,637

false

This entry contains proteins belonging to the UPF0496 family, found in plants. This family includes AT14A like proteins from Arabidopsis thaliana. At14a contains a small domain that has sequence similarities to integrins from fungi, insects and humans. Transcripts of At14a are found in all Arabidopsis tissues and the p...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05055", "PTHR31113" ]

[ "DUF677", "" ]

[ 4086, 4461 ]

2

[]

0

[]

0

[ "PUB00010152" ]

[ "10196471" ]

[ "Isolation and characterization of a cDNA clone from Arabidopsis thaliana with partial sequence similarity to integrins." ]

[ 1999 ]

1

[]

0

null

[ "Candidatus Sungiibacteriota", "Eukaryota" ]

[ 2, 4635 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 61, 20, 25 ]

3

true

Family

Protein of unknown function DUF677

DUF677

4

IPR007751

7,751

Domain of unknown function DUF676, lipase-like

DUF676_lipase-like

Domain

19,058

false

This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B [ ].

[]

0

[ "PFAM" ]

[ "PF05057" ]

[ "DUF676" ]

[ 19058 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9696273", "R-MMU-9696273" ]

[ "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-9696273" ]

2

[]

0

[ "PUB00073522" ]

[ "25014274" ]

[ "Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Natrialbaceae", "Viruses", "unclassified sequences" ]

[ 1204, 17827, 5, 3, 19 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 44, 3, 21, 3, 3, 9, 5, 25, 5, 4, 1, 90 ]

12

true

Domain

Domain of unknown function DUF676, lipase-like

DUF676_lipase-like

7

IPR007752

7,752

Virulence factor ActA

Virulence_actor_ActA

Family

862

false

The ActA family is found in Listeria and is associated with motility. ActA protein acts as a scaffold to assemble and activate host cell actin cytoskeletal factors at the bacterial surface, resulting in directional actin polymerisation and propulsion of the bacterium through the cytoplasm of the host cell [ , ].

[]

0

[ "PFAM" ]

[ "PF05058" ]

[ "ActA" ]

[ 862 ]

1

[]

0

[]

0

[ "PUB00010526", "PUB00010527" ]

[ "11886549", "11854187" ]

[ "Systematic mutational analysis of the amino-terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin-based motility.", "Intracellular induction of Listeria monocytogenes actA expression." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Listeria" ]

[ 862 ]

1

[]

0

true

Family

Virulence factor ActA

Virulence_actor_ActA

2

IPR007753

7,753

Orbivirus VP4 core

Orbi_VP4

Family

875

false

Orbivirus are double stranded RNA retroviruses of which the Bluetongue virus (BTV) is a member. The core of BTV is a multienzyme complex composed of two major proteins (VP7 and VP3) and three minor proteins (VP1, VP4 and VP6) in addition to the viral genome. VP4 has been shown to perform all RNA capping activities and ...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM", "CDD" ]

[ "PF05059", "cd20758" ]

[ "Orbi_VP4", "capping_2-OMTase_Orbivirus" ]

[ 875, 849 ]

2

[ "GP" ]

[ "GenProp1006" ]

[ "GP:GenProp1006" ]

1

[ "2jh8", "2jh9", "2jha", "2jhc", "2jhp" ]

5

[ "PUB00010198", "PUB00041935" ]

[ "9811835", "17417654" ]

[ "Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus.", "Bluetongue virus VP4 is an RNA-capping assembly line." ]

[ 1998, 2007 ]

2

[]

0

null

[ "Riboviria", "viral metagenome" ]

[ 874, 1 ]

2

[]

0

true

Family

Orbivirus VP4 core

Orbi_VP4

2

IPR007754

7,754

N-acetylglucosaminyltransferase II

GlcNAc_II

Family

2,987

false

N-acetylglucosaminyltransferase II ( ) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [ ]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased blee...

[ "GO:0008455", "GO:0009312", "GO:0005795", "GO:0016020" ]

[ "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "oligosaccharide biosynthetic process", "Golgi stack", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05060", "PTHR12871" ]

[ "MGAT2", "" ]

[ 2981, 2912 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.143", "GenProp1444", "GenProp1524", "PWY-7426", "PWY-7920", "R-HSA-4793952", "R-HSA-9694548", "R-HSA-975578", "R-MMU-975578", "R-RNO-975578" ]

[ "EC:2.4.1.143", "GP:GenProp1444", "GP:GenProp1524", "METACYC:PWY-7426", "METACYC:PWY-7920", "REACTOME:R-HSA-4793952", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-975578", "REACTOME:R-MMU-975578", "REACTOME:R-RNO-975578" ]

10

[ "5vcm", "5vcr", "5vcs" ]

3

[ "PUB00010179", "PUB00010180" ]

[ "7797505", "11596651" ]

[ "Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II.", "Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications." ]

[ 1995, 2001 ]

2

[]

0

null

[ "Eukaryota", "Undibacterium umbellatum" ]

[ 2986, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 2, 2, 7, 2, 4, 3, 2, 3 ]

9

true

Family

N-acetylglucosaminyltransferase II

GlcNAc_II

6

IPR007755

7,755

Poxvirus A11

Poxvirus_A11

Family

150

false

This entry represents Protein A11 from Vaccinia virus, also known as Protein OPG137, and similar sequences from poxvirus. A11 is required for viral crescent formation early during virus morphogenesis [ ]. A conserved region spans the entire protein in the majority of family members.

[]

0

[ "PFAM" ]

[ "PF05061" ]

[ "Pox_A11" ]

[ 150 ]

1

[]

0

[]

0

[ "PUB00103619" ]

[ "15890898" ]

[ "Vaccinia virus nonstructural protein encoded by the A11R gene is required for formation of the virion membrane." ]

[ 2005 ]

1

[]

0

null

[ "Poxviridae" ]

[ 150 ]

1

[]

0

true

Family

Poxvirus A11

Poxvirus_A11

5

IPR007756

7,756

RICH domain

RICH

Domain

420

false

This domain is about 85 residues in length and very rich in charged residues, hence the name RICH (Rich In CHarged residues). It is found in secreted proteins such as PspC , SpsA and IgA FC receptor from Streptococcus agalactiae. This domain could be involved in bacterial adherence or cell wall binding.

[]

0

[ "PFAM" ]

[ "PF05062" ]

[ "RICH" ]

[ 420 ]

1

[]

0

[ "2m6u", "4k12", "6lxw", "7s0r" ]

4

[]

0

[]

0

null

[ "Nitrosopumilus piranensis", "Streptococcus" ]

[ 1, 419 ]

2

[]

0

true

Domain

RICH domain

RICH

7

IPR007757

7,757

MT-A70-like

Family

12,660

false

N6-methyladenosine (m6A) is present at internal sites in some mRNAs. m6A affects different aspects of mRNA metabolism, such as half-life, splicing, and translation [ , , , , ]. MT-A70 (also known as METTL3) is the S-adenosylmethionine-binding subunit of human mRNA N6-adenosine-methyltransferase (MTase), an enzyme that ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05063", "PS51143" ]

[ "MT-A70", "MT_A70" ]

[ 12524, 12474 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51143", "R-DME-72203", "R-GGA-72203", "R-HSA-72203", "R-MMU-72203", "R-XTR-72203" ]

[ "PROSITEDOC:PDOC51143", "REACTOME:R-DME-72203", "REACTOME:R-GGA-72203", "REACTOME:R-HSA-72203", "REACTOME:R-MMU-72203", "REACTOME:R-XTR-72203" ]

6

[ "5il0", "5il1", "5il2", "5k7m", "5k7u", "5k7w", "5l6d", "5l6e", "5tey", "6ttp", "6ttt", "6ttv", "6ttw", "6ttx", "6tu1", "6y4g", "7acd", "7cv6", "7cv7", "7cv8", "7cv9", "7cva", "7dpe", "7f4l", "7f4m", "7f4n", "7f4o", "7f4p", "7f4q", "7f4r", "7f4s", "7f4t"...

92

[ "PUB00018586", "PUB00018587", "PUB00070693", "PUB00087331", "PUB00087332", "PUB00087333", "PUB00087334", "PUB00087335", "PUB00087338" ]

[ "12355263", "12384598", "24316715", "24284625", "26751643", "26593424", "26046440", "25799998", "17101777" ]

[ "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase.", "Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activ...

[ 2002, 2002, 2014, 2014, 2016, 2015, 2015, 2015, 2007 ]

9

[]

[ "IPR025848", "IPR045123" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 13, 2412, 9896, 86, 253 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 9, 4, 10, 11, 1, 15, 14, 2, 1, 15 ]

12

true

Family

MT-A70-like

2

IPR007758

7,758

Nucleoporin, NSP1-like, C-terminal

Nucleoporin_NSP1_C

Domain

4,502

false

The NSP1-like protein appears to be an essential component of the nuclear pore complex, for example preribosome nuclear export requires the Nup82p-Nup159p-Nsp1p complex. The C-terminal of Nsp1 is involved in binding Nup82 [ ], probably via coiled-coil formation [ , ]. The family is related to the rotavirus nonstructura...

[]

0

[ "PFAM" ]

[ "PF05064" ]

[ "Nsp1_C" ]

[ 4502 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

85

[ "3t97", "5c3l", "5cws", "5h1x", "5ijn", "5ijo", "7n85", "7n9f", "7per", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7tdz", "7vop", "7wkk", "7woo", "7wot", "8tj5", "9hcj", "9sob" ]

24

[ "PUB00010195", "PUB00034646" ]

[ "11689687", "17037504" ]

[ "The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.", "Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture." ]

[ 2001, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)", "Nora virus" ]

[ 2, 4498, 1, 1 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 4, 1, 7, 11, 1, 1, 5, 1, 1, 5 ]

11

true

Domain

Nucleoporin, NSP1-like, C-terminal

Nucleoporin_NSP1_C

4

IPR007759

7,759

ASXL, HARE-HTH domain

Asxl_HARE-HTH

Domain

10,035

false

This domain, known as the HARE-HTH domain, adopts the winged helix-turn-helix fold and is predicted to bind DNA. It can be found at the N terminus of the ASXL protein. It can also be found in several other eukaryotic chromatin proteins (such as HB1 in plants), diverse restriction endonucleases and DNA glycosylases, the...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05066", "PS51913" ]

[ "HARE-HTH", "HTH_HARE" ]

[ 9026, 9619 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5689603", "R-MMU-5689603" ]

[ "REACTOME:R-HSA-5689603", "REACTOME:R-MMU-5689603" ]

2

[ "2krc", "2m4k", "4nc7", "4nc8", "6zca", "6zfb", "7f75", "8h1t", "8svf", "8x6g", "8xa6", "8xa7", "8xa8" ]

13

[ "PUB00010212", "PUB00010213", "PUB00066749", "PUB00067481", "PUB00097400" ]

[ "10336502", "7545758", "16606617", "22186017", "20310067" ]

[ "Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis.", "Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase.", "Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-de...

[ 1999, 1995, 2006, 2012, 2010 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 18, 5199, 4780, 38 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 10, 24, 14, 4, 7, 111 ]

7

true

Domain

ASXL, HARE-HTH domain

Asxl_HARE-HTH

4

IPR007760

7,760

Manganese catalase

Mn_catalase

Family

9,203

false

Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via transition metals, this radical being able to damage a w...

[]

0

[ "PFAM" ]

[ "PF05067" ]

[ "Mn_catalase" ]

[ 9203 ]

1

[ "EC", "GP" ]

[ "1.11.1.6", "GenProp0213" ]

[ "EC:1.11.1.6", "GP:GenProp0213" ]

2

[ "1jku", "1jkv", "1o9i", "2cwl", "2v8t", "2v8u", "4r42", "6j42", "6kk8" ]

9

[ "PUB00010186", "PUB00015054", "PUB00015059" ]

[ "11587647", "14745498", "14871145" ]

[ "Crystal structure of manganese catalase from Lactobacillus plantarum.", "Diversity of structures and properties among catalases.", "Structural, spectroscopic, and reactivity models for the manganese catalases." ]

[ 2001, 2004, 2004 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 109, 9029, 8, 53, 4 ]

5

[]

0

true

Family

Manganese catalase

Mn_catalase

3

IPR007761

7,761

Mannitol repressor MtlR-like

MtlR-like

Family

2,227

false

The mannitol operon of Escherichia coli, encoding the mannitol-specific enzyme II of the phosphotransferase system (MtlA) and mannitol phosphate dehydrogenase (MtlD) contains an additional downstream open reading frame which encodes the mannitol repressor (MtlR). Although it is involved in the repression of the express...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05068", "PTHR37941" ]

[ "MtlR", "" ]

[ 2013, 2208 ]

2

[ "GP" ]

[ "GenProp1267" ]

[ "GP:GenProp1267" ]

1

[ "3brj", "3c8g", "6kcr" ]

3

[ "PUB00054509" ]

[ "19840941" ]

[ "The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Opisthokonta", "metagenomes" ]

[ 2211, 3, 2, 11 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Mannitol repressor MtlR-like

MtlR-like

6

IPR007763

7,763

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

NDUFA12

Family

10,441

false

This entry includes the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12) and the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (NDUFAF2). NDUFA12 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) [ , ], not involved in ca...

[ "GO:0016020", "GO:0045271" ]

[ "membrane", "respiratory chain complex I" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05071", "PTHR12910" ]

[ "NDUFA12", "" ]

[ 10388, 7479 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

6

[ "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6x89", "6y79", "6yj4"...

265

[ "PUB00014526", "PUB00060842", "PUB00086425", "PUB00086570", "PUB00156042" ]

[ "14741580", "12611891", "23648483", "27626371", "34069703" ]

[ "The gross structure of the respiratory complex I: a Lego System.", "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.", "Novel insights into the role of Neurospora crassa NDUFAF2, an evolutionarily conserved mitochondrial complex I assembly factor.", "Acce...

[ 2004, 2003, 2013, 2016, 2021 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2856, 7549, 36 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 2, 2, 3, 14, 9, 3, 9, 8, 17 ]

10

true

Family

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

NDUFA12

3

IPR007764

7,764

Herpesvirus UL43

Herpes_UL43

Family

223

false

UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component [ ]. Studies suggest that the N-terminal sequences target UL43 to protein aggregates and that C-terminal sequences are important for incorporation into particles.

[ "GO:0016020", "GO:0019033" ]

[ "membrane", "viral tegument" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05072" ]

[ "Herpes_UL43" ]

[ 223 ]

1

[]

0

[]

0

[ "PUB00010171" ]

[ "12029146" ]

[ "The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are tegument components." ]

[ 2002 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 223 ]

1

[]

0

true

Family

Herpesvirus UL43

Herpes_UL43

1

IPR007765

7,765

Baculovirus p24 capsid

Baculo_p24

Family

155

false

The Culex nigripalpus NPV (Culex nigripalpus nucleopolyhedrovirus) protein p24 is associated with nucleocapsids of budded and polyhedra-derived virions [ , ].

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05073" ]

[ "Baculo_p24" ]

[ 155 ]

1

[]

0

[]

0

[ "PUB00010528", "PUB00010529" ]

[ "11602755", "8423444" ]

[ "Genome sequence of a baculovirus pathogenic for Culex nigripalpus.", "Immunocytochemical characterization of p24, a baculovirus capsid-associated protein." ]

[ 2001, 1993 ]

2

[]

0

null

[ "Bacteria", "Baculoviridae", "Coelogyne serratoi" ]

[ 3, 151, 1 ]

3

[]

0

true

Family

Baculovirus p24 capsid

Baculo_p24

2

IPR007767

7,767

Protein of unknown function DUF684

DUF684

Family

319

false

This family contains uncharacterised proteins from Caenorhabditis species.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05075", "PTHR31464" ]

[ "DUF684", "" ]

[ 313, 301 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 319 ]

1

[ "Caenorhabditis elegans" ]

[ 11 ]

1

true

Family

Protein of unknown function DUF684

DUF684

5

IPR007768

7,768

Suppressor of fused

Suppressor_of_fused

Family

2,948

false

Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling [ ]. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [ ], and functions by binding these proteins and preventing their translocation...

[]

0

[ "PANTHER" ]

[ "PTHR10928" ]

[ "" ]

[ 2948 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5610780", "R-HSA-5610783", "R-HSA-5610785", "R-HSA-5610787", "R-HSA-5632684", "R-MMU-5610780", "R-MMU-5610785", "R-MMU-5610787", "R-MMU-5632684" ]

[ "REACTOME:R-HSA-5610780", "REACTOME:R-HSA-5610783", "REACTOME:R-HSA-5610785", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5632684", "REACTOME:R-MMU-5610780", "REACTOME:R-MMU-5610785", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5632684" ]

9

[ "1m1l", "4bl8", "4bl9", "4bla", "4blb", "4bld", "4km8", "4km9", "4kma", "4kmd", "4kmh", "6lph" ]

12

[ "PUB00010225", "PUB00010226", "PUB00101143" ]

[ "12150819", "12068298", "28965847" ]

[ "Medulloblastoma: a problem of developmental biology.", "Mutations in SUFU predispose to medulloblastoma.", "Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects." ]

[ 2002, 2002, 2017 ]

3

[]

[ "IPR016591", "IPR017429" ]

0

2

0

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 975, 1972, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 4, 4, 4 ]

5

true

Family

Suppressor of fused

Suppressor_of_fused

9

IPR007769

7,769

Poxvirus A19

Poxvirus_A19

Family

103

false

This entry represents Protein A19 from Vaccinia virus, also known as Protein OPG146, and similar sequences from poxvirus. A19 plays a role in the maturation of immature virions to infectious particles. It may also participate in viral transcription [ , ].

[]

0

[ "PFAM" ]

[ "PF05077" ]

[ "DUF678" ]

[ 103 ]

1

[]

0

[]

0

[ "PUB00103624", "PUB00103625" ]

[ "23885081", "23885084" ]

[ "Vaccinia virus A19 protein participates in the transformation of spherical immature particles to barrel-shaped infectious virions.", "Interactions of the vaccinia virus A19 protein." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Poxviridae" ]

[ 103 ]

1

[]

0

true

Family

Poxvirus A19

Poxvirus_A19

5

IPR007770

7,770

Protein DMP

DMP

Family

5,028

false

This entry includes plant protein DMP, including Arabidopsis AtDMP1-10. DMP1 is a membrane protein that may be involved in membrane fission during breakdown of the ER and the tonoplast during leaf senescence and in membrane fusion during vacuole biogenesis in roots [ ]. DMP8 and DMP9 have been shown to facilitate gamet...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05078", "PTHR31621" ]

[ "DUF679", "" ]

[ 5026, 4942 ]

2

[]

0

[]

0

[ "PUB00086645", "PUB00093467" ]

[ "22530652", "30850817" ]

[ "Arabidopsis senescence-associated protein DMP1 is involved in membrane remodeling of the ER and tonoplast.", "Gamete fusion is facilitated by two sperm cell-expressed DUF679 membrane proteins." ]

[ 2012, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5028 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 50, 36 ]

3

true

Family

Protein DMP

DMP

5

IPR007771

7,771

Protein of unknown function DUF680

DUF680

Family

423

false

This family contains several uncharacterised proteins which seem to be found exclusively in Rhizobiales.

[]

0

[ "PFAM" ]

[ "PF05079" ]

[ "DUF680" ]

[ 423 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Phyllobacteriaceae" ]

[ 423 ]

1

[]

0

true

Family

Protein of unknown function DUF680

DUF680

7

IPR007772

7,772

Beak and feather disease virus (BFDV), Orf5

BFDV_Orf5

Family

35

false

This entry is represented by Beak and feather disease virus (BFDV), Orf5; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF05080" ]

[ "DUF681" ]

[ 35 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Beak and feather disease virus" ]

[ 35 ]

1

[]

0

true

Family

Beak and feather disease virus (BFDV), Orf5

BFDV_Orf5

9

IPR007773

7,773

Autographa californica nuclear polyhedrosis virus (AcMNPV), P18

AcMNPV_P18

Family

127

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), P18; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF05081" ]

[ "AcMNPV_P18" ]

[ 127 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 127 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), P18

AcMNPV_P18

5

IPR007774

7,774

Putative nitrogen fixation protein

Put_N_fixation

Family

979

false

This family contains several uncharacterised bacterial proteins. These proteins are found in nitrogen fixation operons, so are likely to play some role in this process. They consist of two α helices which are joined by a four residue linker. The helices form an antiparallel bundle and cross towards their termini. They ...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05082", "PIRSF037676" ]

[ "Rop-like", "DUF683" ]

[ 979, 894 ]

2

[]

0

[ "2js5", "3csx" ]

2

[ "PUB00052824" ]

[ "19336042" ]

[ "Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 969, 10 ]

2

[]

0

true

Family

Putative nitrogen fixation protein

Put_N_fixation

7

IPR007775

7,775

Leukocyte-specific transcript 1, LST-1

Leukocyte-sp_tscrpt_1_LST1

Family

270

false

B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic change...

[ "GO:0000902", "GO:0006955", "GO:0016020" ]

[ "cell morphogenesis", "immune response", "membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05083", "PIRSF037638", "PTHR15452" ]

[ "LST1", "Leukocyte-sp_tscrpt_1_LST1", "" ]

[ 270, 26, 210 ]

3

[]

0

[]

0

[ "PUB00010178", "PUB00053473" ]

[ "11478849", "10706707" ]

[ "Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells.", "LST1: a gene with extensive alternative splicing and immunomodulatory function." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Bilateria" ]

[ 270 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 6, 5 ]

3

true

Family

Leukocyte-specific transcript 1, LST-1

Leukocyte-sp_tscrpt_1_LST1

1

IPR007777

7,777

Protein of unknown function DUF685

DUF685

Family

210

false

This family consists of uncharacterised proteins from Borrelia species. There is some evidence to suggest that the proteins may be outer surface proteins.

[]

0

[ "PFAM" ]

[ "PF05085" ]

[ "DUF685" ]

[ 210 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 210 ]

1

[]

0

true

Family

Protein of unknown function DUF685

DUF685

3

IPR007778

7,778

Dictyostelium REP

Dict_REP

Family

21

false

This family consists of REP proteins from a number of Dictyostelium species (Slime molds). REP protein is probably involved in transcription regulation and control of DNA replication, specifically the amplification of plasmid at low copy numbers. The formation of homomultimers may be required for their regulatory activ...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05086", "PIRSF018468" ]

[ "Dicty_REP", "Dict_REP" ]

[ 21, 6 ]

2

[]

0

[]

0

[ "PUB00010153" ]

[ "10366530" ]

[ "Mechanism of action of the Rep protein from the Dictyostelium Ddp2 plasmid family." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota", "uncultured bacterium (gcode 4)" ]

[ 20, 1 ]

2

[]

0

true

Family

Dictyostelium REP

Dict_REP

5

IPR007779

7,779

Rotavirus VP2

Rotavirus_VP2

Family

3,711

false

Rotavirus particles consist of three concentric proteinaceous capsid layers. The innermost capsid (core) is made of VP2. The genomic RNA and the two minor proteins VP1 and VP3 are encapsidated within this layer [ ]. The N terminus of rotavirus VP2 is necessary for the encapsidation of VP1 and VP3 [ ].

[ "GO:0003723", "GO:0019013" ]

[ "RNA binding", "viral nucleocapsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "HAMAP", "PFAM" ]

[ "MF_04123", "MF_04127", "PF05087" ]

[ "Rota_VP2", "Rota_VP2_A", "Rota_VP2" ]

[ 3043, 2783, 3635 ]

3

[]

0

[ "3gzu", "3kz4", "4f5x", "4v7q", "6ogy", "6ogz", "6oj3", "6oj4", "6oj5", "6oj6", "8bp8", "8co6", "8olb", "8olc", "9c1g", "9c1h", "9c1j", "9c1k", "9c1l" ]

19

[ "PUB00010218", "PUB00010219" ]

[ "8178489", "9420216" ]

[ "Characterization of rotavirus VP2 particles.", "The N terminus of rotavirus VP2 is necessary for encapsidation of VP1 and VP3." ]

[ 1994, 1998 ]

2

[]

0

null

[ "Sedoreoviridae" ]

[ 3711 ]

1

[]

0

true

Family

Rotavirus VP2

Rotavirus_VP2

7

IPR007780

7,780

NAD-glutamate dehydrogenase, bacteria

NAD_Glu_DH_bac

Family

10,171

false

This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to ketoglutarate and ammonia [ ].

[ "GO:0004069", "GO:0004352", "GO:0006538" ]

[ "L-aspartate:2-oxoglutarate aminotransferase activity", "glutamate dehydrogenase (NAD+) activity", "L-glutamate catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF036761", "PTHR43403" ]

[ "GDH_Mll4104", "" ]

[ 8883, 10171 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.4.1.2", "PWY-5022", "PWY-6728", "PWY-7126", "PWY-8190" ]

[ "EC:1.4.1.2", "METACYC:PWY-5022", "METACYC:PWY-6728", "METACYC:PWY-7126", "METACYC:PWY-8190" ]

5

[ "7a1d", "7jsr" ]

2

[ "PUB00010144" ]

[ "10924516" ]

[ "A new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9999, 48, 124 ]

3

[]

0

true

Family

NAD-glutamate dehydrogenase, bacteria

NAD_Glu_DH_bac

6

IPR007781

7,781

Alpha-N-acetylglucosaminidase

NAGLU

Family

6,260

false

Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate [ ]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mi...

[]

0

[ "PANTHER" ]

[ "PTHR12872" ]

[ "" ]

[ 6260 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2024096", "R-HSA-2206282" ]

[ "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-2206282" ]

2

[ "2vc9", "2vca", "2vcb", "2vcc", "4a4a", "4xwh", "7mfk", "7mfl" ]

8

[ "PUB00010190", "PUB00010191" ]

[ "10588735", "12049639" ]

[ "Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase.", "Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer." ]

[ 1999, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2307, 3925, 28 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 3, 1, 10, 2, 5, 5, 26 ]

9

true

Family

Alpha-N-acetylglucosaminidase

NAGLU

4

IPR007783

7,783

Eukaryotic translation initiation factor 3 subunit D

eIF3d

Family

5,321

false

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [ , ]. The gene coding for...

[ "GO:0003743", "GO:0005737", "GO:0005852" ]

[ "translation initiation factor activity", "cytoplasm", "eukaryotic translation initiation factor 3 complex" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_03003", "PF05091", "PIRSF016281", "PTHR12399" ]

[ "eIF3d", "eIF-3_zeta", "EIF-3_zeta", "" ]

[ 3950, 5316, 4075, 5222 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-CEL-156827", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "...

50

[ "5k4b", "5k4c", "5k4d", "6fec", "6w2t", "6yam", "6ybd", "6ybs", "6zmw", "6zon", "6zp4", "6zvj", "7a09", "7ase", "7qp6", "7qp7", "8oz0", "8pj1", "8pj2", "8pj3", "8pj4", "8pj5", "8pj6", "8ppl", "8rg0", "8xxn", "9bln", "9cpa" ]

28

[ "PUB00005773", "PUB00010249", "PUB00064801" ]

[ "8995409", "11733359", "15904532" ]

[ "Conservation and diversity of eukaryotic translation initiation factor eIF3.", "Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer.", "PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes." ]

[ 1997, 2001, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5321 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 7, 1, 1, 3, 7, 2, 1, 3, 4, 1, 9 ]

11

true

Family

Eukaryotic translation initiation factor 3 subunit D

eIF3d

4

IPR007784

7,784

Per os infectivity factor

PIR

Family

313

false

This entry represents a group of dsDNA Baculovirus proteins. It is required for the infectivity of the OBs or occlusion bodies. It is a structural protein of the ODV envelope required only in the first steps of per os larva infection, as viruses being produced in cells expressing the gene for this protein but not conta...

[]

0

[ "PFAM" ]

[ "PF05092" ]

[ "PIF" ]

[ 313 ]

1

[]

0

[]

0

[ "PUB00055949" ]

[ "12466478" ]

[ "Characterization of pif, a gene required for the per os infectivity of Spodoptera littoralis nucleopolyhedrovirus." ]

[ 2002 ]

1

[]

0

null

[ "Arthropoda", "Lefavirales" ]

[ 54, 259 ]

2

[]

0

true

Family

Per os infectivity factor

PIR

3

IPR007785

7,785

Anamorsin

Family

5,073

false

Anamorsin (also named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1), is the human homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis [ , , , ]. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [...

[ "GO:0051536", "GO:0016226", "GO:0005737" ]

[ "iron-sulfur cluster binding", "iron-sulfur cluster assembly", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PANTHER" ]

[ "MF_03115", "PTHR13273" ]

[ "Anamorsin", "" ]

[ 4304, 5007 ]

2

[ "REACTOME" ]

[ "R-HSA-2564830" ]

[ "REACTOME:R-HSA-2564830" ]

1

[ "2ld4", "2yui", "4m7r" ]

3

[ "PUB00053843", "PUB00055951", "PUB00055952", "PUB00056284", "PUB00059395", "PUB00064826", "PUB00067100" ]

[ "14970183", "18625724", "18299278", "21700214", "22487307", "20802492", "23596212" ]

[ "Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis.", "Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis.", "Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo.", ...

[ 2004, 2008, 2008, 2011, 2012, 2010, 2013 ]

7

[]

0

null

[ "Eukaryota" ]

[ 5073 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 1, 9, 3, 1, 3, 4, 1, 1, 13 ]

12

true

Family

Anamorsin

9

IPR007786

7,786

Late expression factor 9

LEF-9

Family

475

false

The baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) encodes a DNA-dependent RNA polymerase that is required for transcription of viral late genes. This polymerase is composed of four equimolar subunits, LEF-8, LEF-4, LEF-9, and p47. LEF-9 is homologous to the largest beta-subunit of prokaryotic D...

[ "GO:0019083" ]

[ "viral transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05094" ]

[ "LEF-9" ]

[ 475 ]

1

[]

0

[]

0

[ "PUB00008715" ]

[ "12124466" ]

[ "Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus." ]

[ 2002 ]

1

[]

0

null

[ "Baculoviridae", "Cotesia" ]

[ 472, 3 ]

2

[]

0

true

Family

Late expression factor 9

LEF-9

5

IPR007787

7,787

Protein of unknown function DUF687

DUF687

Family

61

false

This family contains uncharacterised Chlamydia proteins.

[]

0

[ "PFAM" ]

[ "PF05095" ]

[ "DUF687" ]

[ 61 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 60, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF687

DUF687

6

IPR007788

7,788

Glutaminyl-peptide cyclotransferase

QCT

Family

5,451

false

QCT converts glutamine and N-terminal glutamyl residues in peptides to 5-oxoproline and 5-oxoproline residues [ , ].

[ "GO:0016603", "GO:0017186" ]

[ "glutaminyl-peptide cyclotransferase activity", "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05096", "PTHR31270" ]

[ "Glu_cyclase_2", "" ]

[ 5450, 5367 ]

2

[]

0

[ "2faw", "2iwa", "3mbr", "3nok", "3nol", "3nom" ]

6

[ "PUB00053847", "PUB00053848" ]

[ "17261077", "18768907" ]

[ "Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.", "A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis." ]

[ 2007, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 22, 3937, 1414, 78 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 4, 7 ]

3

true

Family

Glutaminyl-peptide cyclotransferase

QCT

7

IPR007789

7,789

Protein of unknown function DUF688

DUF688

Family

4,515

false

This entry consists of uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF05097" ]

[ "DUF688" ]

[ 4515 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Clostridium novyi A str. 4552", "Embryophyta" ]

[ 1, 4514 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 69, 28, 37 ]

3

true

Family

Protein of unknown function DUF688

DUF688

3

IPR007790

7,790

Late expression factor 4

LEF-4

Family

208

false

The baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) virus encodes a DNA-dependent RNA polymerase that is required for transcription of viral late genes. This polymerase is composed of four equimolar subunits, LEF-8, LEF-4, LEF-9, and p47. LEF-4 carries out all the enzymatic functions related to m...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05098" ]

[ "LEF-4" ]

[ 208 ]

1

[]

0

[]

0

[ "PUB00008715" ]

[ "12124466" ]

[ "Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus." ]

[ 2002 ]

1

[]

0

null

[ "Arthropoda", "Lefavirales" ]

[ 29, 179 ]

2

[]

0

true

Family

Late expression factor 4

LEF-4

4

IPR007791

7,791

Co-chaperone DjlA, N-terminal

DjlA_N

Domain

19,374

false

This entry represents the N-terminal of the DjlA protein. This domain can also be found in the tellurium resistance protein TerB.

[]

0

[ "PFAM" ]

[ "PF05099" ]

[ "TerB" ]

[ 19374 ]

1

[]

0

[ "2h5n", "2jxu", "2ou3" ]

3

[ "PUB00053678", "PUB00053679", "PUB00069768" ]

[ "11758943", "11106641", "12655402" ]

[ "Characterization of the RcsC-->YojN-->RcsB phosphorelay signaling pathway involved in capsular synthesis in Escherichia coli.", "DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.", "The transmembrane domain of the DnaJ-lik...

[ 2001, 2001, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 15, 18934, 51, 19, 355 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Co-chaperone DjlA, N-terminal

DjlA_N

6

IPR007792

7,792

Type IV secretion system VirB3/TrbD-like

T4SS_VirB3/TrbD-like

Family

7,044

false

This entry represents type IV secretion system proteins VirB3, TrbD and AvhB. Type IV secretion systems are found in plant and animal pathogens, as well as in symbiotic bacteria. The tumour-inducing (Ti) plasmid of Rhizobium radiobacter (Agrobacterium tumefaciens) encodes two DNA transfer systems: VirB and Trb, where t...

[]

0

[ "PFAM" ]

[ "PF05101" ]

[ "VirB3" ]

[ 7044 ]

1

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[ "7o41", "7oiu", "8rtb", "8rtd" ]

4

[ "PUB00008409", "PUB00010244", "PUB00020483", "PUB00053381" ]

[ "8763954", "8405938", "9679196", "12169609" ]

[ "The conjugal transfer system of Agrobacterium tumefaciens octopine-type Ti plasmids is closely related to the transfer system of an IncP plasmid and distantly related to Ti plasmid vir genes.", "Membrane location of the Ti plasmid VirB proteins involved in the biosynthesis of a pilin-like conjugative structure o...

[ 1996, 1993, 1998, 2002 ]

4

[]

[ "IPR016704" ]

0

1

0

[ "Bacteria", "Opisthokonta", "metagenomes", "plasmids", "uncultured Caudovirales phage" ]

[ 6981, 9, 44, 9, 1 ]

5

[]

0

true

Family

Type IV secretion system VirB3/TrbD-like

T4SS_VirB3/TrbD-like

6

IPR007793

7,793

DivIVA

Family

15,589

false

The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate minicells [ ]. Inactivation of divIVA produces a minicell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype [ ]. These proteins appear to...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05103", "PTHR35794" ]

[ "DivIVA", "" ]

[ 14119, 14334 ]

2

[]

0

[ "2wuj", "2wuk", "4ug1", "4ug3", "4uos", "6gp7", "6gpz", "6gqa", "6gqn", "6lfa", "7o39", "8e2b", "8e2c", "9pv2" ]

14

[ "PUB00010155" ]

[ "9045828" ]

[ "The divIVA minicell locus of Bacillus subtilis." ]

[ 1997 ]

1

[]

[ "IPR011229" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 15356, 6, 2, 225 ]

4

[]

0

true

Family

DivIVA

1

IPR007794

7,794

Ribosome receptor lysine/proline rich

Rib_rcpt_KP

Domain

3,790

false

The ribosome receptor is an integral endoplasmic reticulum protein that has been suggested to be involved in secretion. This highly conserved region is found towards the C terminus of the transmembrane domain [ ]. The function is unclear.

[ "GO:0015031", "GO:0005789" ]

[ "protein transport", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05104" ]

[ "Rib_recp_KP_reg" ]

[ 3790 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-5625970", "R-HSA-8957275", "R-HSA-8980692", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013408", "R-HSA-9696264", "R-HSA-9696270", "R-HSA-9725370", "R-MMU-381426", "R-MMU-5625970", "R-MMU-8957275", "R-MMU-8980692", "R-MMU-9013148", "R-MMU-9013149", "R-MMU-9013408...

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-5625970", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-381426", "REACTOME:...

19

[]

0

[ "PUB00010217" ]

[ "11836413" ]

[ "An endoplasmic reticulum protein, p180, is highly expressed in human cytomegalovirus-permissive cells and interacts with the tegument protein encoded by UL48." ]

[ 2002 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 3790 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 15, 24, 12 ]

4

true

Domain

Ribosome receptor lysine/proline rich

Rib_rcpt_KP

1

IPR007795

7,795

Type VII secretion system EccB

T7SS_EccB

Family

5,525

false

The proteins in this family are found in Actinobacteria and are part of type VII secretion system (T7SS) [ ]. This entry represents the transmembrane protein EccB of actinobacterial type VII secretion systems. EccB (ESX conserved component B) is a core component of the T7SS architecture. Species such as Mycobacterium t...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF05108", "PTHR40765", "TIGR03919" ]

[ "T7SS_ESX1_EccB", "", "T7SS_EccB" ]

[ 5525, 5447, 5162 ]

3

[ "GP" ]

[ "GenProp0904" ]

[ "GP:GenProp0904" ]

1

[ "3x3m", "3x3n", "4kk7", "5cyu", "5ebc", "5ebd", "6lar", "6sgw", "6sgx", "6sgy", "6sgz", "6umm", "7b9f", "7b9s", "7np7", "7npr", "7nps", "7npu", "7npv" ]

19

[ "PUB00053896", "PUB00077094" ]

[ "19876390", "26396239" ]

[ "Systematic genetic nomenclature for type VII secretion systems.", "Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase." ]

[ 2009, 2015 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 5518, 7 ]

2

[]

0

true

Family

Type VII secretion system EccB

T7SS_EccB

5

IPR007796

7,796

Envelope glycoprotein GP350, N-terminal, A domain, herpervirus

GP350_N_A_dom_herpes

Domain

235

false

This entry represents domain A of the N-terminal region of GP350. This domain is located in the middle of the "L-shape" structure adopted by the N-terminal, bridging domain B on one side and domain C on the other [ ]. This entry includes Envelope glycoprotein GP350 from Epstein-Barr virus (also known as BLLF1 viral lat...

[]

0

[ "PFAM" ]

[ "PF05109" ]

[ "Herpes_gp350_A" ]

[ 235 ]

1

[]

0

[ "2h6o", "8sgn", "8sic", "8sm0", "8sm1", "8zni" ]

6

[ "PUB00010530", "PUB00041292", "PUB00100089" ]

[ "11024143", "17072314", "32650039" ]

[ "Infectious Epstein-Barr virus lacking major glycoprotein BLLF1 (gp350/220) demonstrates the existence of additional viral ligands.", "Structure of the Epstein-Barr virus major envelope glycoprotein.", "Recombinant Epstein-Barr virus glycoprotein 350 as a serological antigen." ]

[ 2000, 2006, 2020 ]

3

[]

0

null

[ "Lymphocryptovirus" ]

[ 235 ]

1

[]

0

true

Domain

Envelope glycoprotein GP350, N-terminal, A domain, herpervirus

GP350_N_A_dom_herpes

8

IPR007797

7,797

AF4/FMR2 family

AF4/FMR2

Family

6,327

false

The AFF (AF4/FMR2) family includes four members: AFF1/AF4, AFF2/FMR2, AFF3/LAF4 and AFF4/AF5q31. All AFF proteins are localized in the cell nucleus and are involved in regulation of gene expression [ , ]. In humans, AFF2/FMR2 is silenced in FRAXE intellectual disability, while the other three members have been reported...

[ "GO:0010468" ]

[ "regulation of gene expression" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR10528" ]

[ "" ]

[ 6327 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-112382", "R-DME-674695", "R-DME-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955" ]

[ "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955" ]

9

[ "4imy", "4ogr", "4or5", "5jw9", "5l1z", "6cyt", "6k7p", "6kn5", "6r80" ]

9

[ "PUB00010134", "PUB00010135", "PUB00094427", "PUB00101222" ]

[ "11171403", "11171404", "21330300", "32265480" ]

[ "Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth.", "Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian.", "Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the ...

[ 2001, 2001, 2011, 2020 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6327 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 3, 42, 18, 20 ]

5

true

Family

AF4/FMR2 family

AF4/FMR2

3

IPR007798

7,798

Ameloblastin precursor

Amelin

Family

334

false

This family consists of mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralization. One of the non-amelogenin proteins is amelobl...

[ "GO:0030345", "GO:0042475" ]

[ "structural constituent of tooth enamel", "odontogenesis of dentin-containing tooth" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "SMART" ]

[ "PF05111", "PTHR14115", "SM00817" ]

[ "Amelin", "", "Amelin" ]

[ 333, 318, 313 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275", "R-RNO-381426", "R-RNO-8957275", "R-SSC-381426", "R-SSC-8957275" ]

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275", "REACTOME:R-SSC-381426", "REACTOME:R-SSC-8957275" ]

8

[]

0

[ "PUB00010139" ]

[ "11867231" ]

[ "Identification and characterization of ameloblastin gene in a reptile." ]

[ 2002 ]

1

[]

0

null

[ "Sarcopterygii" ]

[ 334 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 5 ]

3

true

Family

Ameloblastin precursor

Amelin

6

IPR007799

7,799

Baculovirus p47

Baculo_p47

Family

158

false

This family consists of several baculoviral p47 proteins which is one of the primary components of Autographa californica nuclear polyhedrosis virus (AcMNPV) encoded RNA polymerase, which initiates transcription from late and very late promoters [ ].

[ "GO:0046782" ]

[ "regulation of viral transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05112" ]

[ "Baculo_p47" ]

[ 158 ]

1

[]

0

[]

0

[ "PUB00010531" ]

[ "9733837" ]

[ "A virus-encoded RNA polymerase purified from baculovirus-infected cells." ]

[ 1998 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 158 ]

1

[]

0

true

Family

Baculovirus p47

Baculo_p47

4

IPR007800

7,800

Protein of unknown function DUF693

DUF693

Family

180

false

This family consists of uncharacterised proteins from Borrelia burgdorferi.

[]

0

[ "PFAM" ]

[ "PF05113" ]

[ "DUF693" ]

[ 180 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 180 ]

1

[]

0

true

Family

Protein of unknown function DUF693

DUF693

6

IPR007801

7,801

RiPP precursor modification enzyme MbnB/TglH/ChrH

MbnB/TglH/ChrH

Family

9,427

false

This entry represents a family of multinuclear iron-containing proteins which are post-translational modification enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products, including the precursor modification enzymes MbnB, TglH, and ChrH, formerly...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PANTHER" ]

[ "MF_00697", "NF050167", "PF05114", "PTHR42194" ]

[ "UPF0276", "MNIO_BufB", "MbnB_TglH_ChrH", "" ]

[ 4200, 4565, 9427, 9171 ]

4

[]

0

[ "3bww", "7dz9", "7fc0", "7tcr", "7tcu", "7tcw", "7tcx", "8hci", "8hi7", "8hi8" ]

10

[ "PUB00106909", "PUB00153337", "PUB00153338", "PUB00161749" ]

[ "35320042", "35362960", "37252350", "39602266" ]

[ "A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis.", "Substrate Recognition by the Peptidyl-(<i>S</i>)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis.", "Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis ...

[ 2022, 2022, 2023, 2024 ]

4

[]

[ "IPR026431", "IPR060770" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9317, 21, 89 ]

3

[]

0

true

Family

RiPP precursor modification enzyme MbnB/TglH/ChrH

MbnB/TglH/ChrH

6

IPR007802

7,802

Cytochrome b6-f complex subunit 6

Cyt_b6/f_cplx_su6

Family

13,406

false

This family consists of several Cytochrome B6-F complex subunit VI (PetL) proteins found in a number of plant species. PetL is one of the small subunits which make up the cytochrome b(6)f complex. PetL is not absolutely required for either the accumulation or for the function of cytochrome b6f; in its absence, however,...

[ "GO:0009055", "GO:0009512" ]

[ "electron transfer activity", "cytochrome b6f complex" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00433", "PF05115", "PTHR37266" ]

[ "Cytb6_f_PetL", "PetL", "" ]

[ 13192, 13125, 12064 ]

3

[ "GP" ]

[ "GenProp1353" ]

[ "GP:GenProp1353" ]

1

[ "1q90", "1vf5", "2d2c", "2e74", "2e75", "2e76", "2zt9", "4h0l", "4h13", "4h44", "4i7z", "4ogq", "4pv1", "6rqf", "7qrm", "7zyv", "9es7", "9es8", "9es9" ]

19

[ "PUB00010203" ]

[ "11796719" ]

[ "Chimeric fusions of subunit IV and PetL in the b6f complex of Chlamydomonas reinhardtii: structural implications and consequences on state transitions." ]

[ 2002 ]

1

[]

0

null

[ "Cyanophyceae", "Eukaryota" ]

[ 214, 13192 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 2 ]

3

true

Family

Cytochrome b6-f complex subunit 6

Cyt_b6/f_cplx_su6

4

IPR007803

7,803

Aspartyl/asparaginy/proline hydroxylase

Asp/Arg/Pro-Hydrxlase

Domain

12,754

false

Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase (P3H) hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserve...

[ "GO:0018193" ]

[ "peptidyl-amino acid modification" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05118" ]

[ "Asp_Arg_Hydrox" ]

[ 12754 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11", "R-BTA-2672351", "R-BTA-5578775", "R-HSA-2672351", "R-HSA-5578775", "R-HSA-9629569", "R-MMU-2672351", "R-MMU-5578775" ]

[ "EC:1.14.11", "REACTOME:R-BTA-2672351", "REACTOME:R-BTA-5578775", "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-5578775", "REACTOME:R-HSA-9629569", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-5578775" ]

8

[ "1e5r", "1e5s", "4p7w", "4p7x", "5apa", "5jqy", "5jtc", "5jz6", "5jz8", "5jza", "5jzu", "6q9f", "6q9i", "6qa5", "6rk9", "6yyu", "6yyv", "6yyw", "6yyx", "6yyy", "6z6q", "6z6r", "7bmi", "7bmj", "7e6j", "7yb8", "7yb9", "7yba", "7ybb", "7ybc", "8re5", "8re6"...

35

[ "PUB00010142", "PUB00020183" ]

[ "8041771", "11737217" ]

[ "A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases.", "Structure of proline 3-hydroxylase. Evolution of the family o...

[ 1994, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Marine Group I thaumarchaeote", "Viruses", "unclassified sequences" ]

[ 7299, 5233, 1, 92, 129 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 7, 7, 17 ]

6

true

Domain

Aspartyl/asparaginy/proline hydroxylase

Asp/Arg/Pro-Hydrxlase

9

IPR007804

7,804

Gas vesicle protein G

GvpG

Family

2,402

false

Gas vesicles are intracellular, protein-coated, and hollow organelles found in cyanobacteria and halophilic archaea. They are permeable to ambient gases by diffusion and provide buoyancy, enabling cells to move upwards in water to access oxygen and/or light. This family represents Gas vesicle protein G from Streptomyce...

[]

0

[ "PFAM" ]

[ "PF05120" ]

[ "GvpG" ]

[ 2402 ]

1

[ "GP" ]

[ "GenProp0460" ]

[ "GP:GenProp0460" ]

1

[]

0

[ "PUB00010168", "PUB00151493" ]

[ "9573198", "31115635" ]

[ "Gas vesicle genes identified in Bacillus megaterium and functional expression in Escherichia coli.", "Discovery of gas vesicles in Streptomyces sp. CB03234-S and potential effects of gas vesicle gene overexpression on morphological and metabolic changes in streptomycetes." ]

[ 1998, 2019 ]

2

[]

[ "IPR054797" ]

0

1

0

[ "Bacteria", "Fungi", "Stenosarchaea group", "ecological metagenomes" ]

[ 2244, 4, 151, 3 ]

4

[]

0

true

Family

Gas vesicle protein G

GvpG

7

IPR007805

7,805

Gas vesicle protein K

GvpK

Family

2,480

false

Gas vesicles are intracellular, protein-coated, and hollow organelles found in cyanobacteria and halophilic archaea. They are permeable to ambient gases by diffusion and provide buoyancy, enabling cells to move upwards in liquid to access oxygen and/or light. This family represents Gas vesicle protein K from Streptomyc...

[ "GO:0031412" ]

[ "gas vesicle organization" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05121", "PTHR40137" ]

[ "GvpK", "" ]

[ 2480, 2467 ]

2

[ "GP" ]

[ "GenProp0460" ]

[ "GP:GenProp0460" ]

1

[]

0

[ "PUB00010169" ]

[ "1404376" ]

[ "Three different but related gene clusters encoding gas vesicles in halophilic archaea." ]

[ 1992 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)", "ecological metagenomes" ]

[ 160, 2317, 1, 2 ]

4

[]

0

true

Family

Gas vesicle protein K

GvpK

5

IPR007806

7,806

Mobile element transfer

SpdB

Family

964

false

This family is found in proteins involved in transferring a group of integrating conjugative DNA elements, such as pSAM2 from Streptomyces ambofaciens during mating [ ]. Their precise role is not known.

[]

0

[ "PFAM" ]

[ "PF05122" ]

[ "SpdB" ]

[ 964 ]

1

[]

0

[]

0

[ "PUB00010229" ]

[ "8366038" ]

[ "Transfer functions of the conjugative integrating element pSAM2 from Streptomyces ambofaciens: characterization of a kil-kor system associated with transfer." ]

[ 1993 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 964 ]

1

[]

0

true

Family

Mobile element transfer

SpdB

5

IPR007808

7,808

Transcription elongation factor 1

Elf1

Family

4,836

false

Transcription elongation factor 1 (Elf1) is a transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05129", "PTHR20934" ]

[ "Zn_ribbon_Elf1", "" ]

[ 4825, 4594 ]

2

[]

0

[ "1wii", "5xog", "6ir9", "6j4w", "6j4x", "6j4y", "6j51", "7wbv", "7wbw", "7wbx", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "8b3d", "8b3f", "8he5", "8jh2", "8ram", "8rap", "8tvy", "8xrm", "9bz0", "9er2", "9fd2", "9hwg", "9ii7", "9rtt" ]

31

[ "PUB00033659" ]

[ "16260625" ]

[ "Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Brevibacillus halotolerans", "Eukaryota", "metagenomes" ]

[ 147, 1, 4683, 5 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 4, 6, 2, 1, 5, 2, 1, 1, 31 ]

12

true

Family

Transcription elongation factor 1

Elf1

4

IPR007809

7,809

FlgN-like protein

FlgN-like

Family

9,066

false

Flagella synthesis protein FlgN is an export chaperone involved in flagellar synthesis [ ]. FlgN consists of a 4 long helices bundle, where the last helix is shorter than the three others. FlgN is required for the export of the hook-filament junction proteins, FlgK and FlgL. It is required for both swimming and swarmin...

[ "GO:0005515", "GO:0044780" ]

[ "protein binding", "bacterial-type flagellum assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05130" ]

[ "FlgN" ]

[ 9066 ]

1

[ "GP" ]

[ "GenProp0881" ]

[ "GP:GenProp0881" ]

1

[ "2fup", "3opc", "5b3d", "8ftx" ]

4

[ "PUB00010163", "PUB00076718" ]

[ "11169117", "24706744" ]

[ "Substrate complexes and domain organization of the Salmonella flagellar export chaperones FlgN and FliT.", "FlgN is required for flagellum-based motility by Bacillus subtilis." ]

[ 2001, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8943, 11, 112 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

FlgN-like protein

FlgN-like

1

IPR007812

7,812

Type II secretion system protein GspL

T2SS_protein-GspL

Family

5,048

false

This family consists of general secretion pathway protein L sequences from several Gram-negative bacteria. GspL is predicted to contain a large cytoplasmic domain and has been shown to interact with the autophosphorylating cytoplasmic membrane protein GspE. It is thought that the tri-molecular complex of GspL, GspE and...

[ "GO:0015628", "GO:0009276", "GO:0015627" ]

[ "protein secretion by the type II secretion system", "Gram-negative-bacterium-type cell wall", "type II protein secretion system complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF015761", "TIGR01709" ]

[ "Protein_L", "typeII_sec_gspL" ]

[ 3107, 5040 ]

2

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "1w97", "1yf5", "2bh1", "4pht", "5tkw" ]

5

[ "PUB00010089", "PUB00051842", "PUB00093998", "PUB00094002", "PUB00094004" ]

[ "10322014", "19217396", "30767847", "28258547", "22523076" ]

[ "Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae.", "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Architecture, Function, and Substrates of the Type II Secretion System.", "1H, ...

[ 1999, 2009, 2019, 2017, 2012 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4951, 8, 89 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Type II secretion system protein GspL

T2SS_protein-GspL

8

IPR007814

7,814

1,2-phenylacetyl-CoA epoxidase, subunit A/C

PaaA_PaaC

Family

15,088

false

This family includes PaaA and PaaC proteins, which are part of a catabolic pathway of phenylacetic acid [ ]. E. coli PaaA and PaaC are components of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyses the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. PaaA is the catal...

[ "GO:0010124" ]

[ "phenylacetate catabolic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05138" ]

[ "PaaA_PaaC" ]

[ 15088 ]

1

[]

0

[ "1otk", "3pvr", "3pvt", "3pvy", "3pw1", "3pw8", "3pwq", "4ii4", "4iit", "4mud" ]

10

[ "PUB00010200", "PUB00055817", "PUB00075378" ]

[ "9748275", "21247899", "20660314" ]

[ "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway.", "Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex.", "Bacterial phenylalanine and phenylacetate catabolic pathway revealed." ]

[ 1998, 2011, 2010 ]

3

[]

[ "IPR011881", "IPR011882" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 454, 14486, 11, 137 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

1,2-phenylacetyl-CoA epoxidase, subunit A/C

PaaA_PaaC

7

IPR007815

7,815

Erythromycin esterase

Emycin_Estase

Family

8,980

false

This entry contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "PFAM", "CDD" ]

[ "PF05139", "cd14728" ]

[ "Erythro_esteras", "Ere-like" ]

[ 8979, 8435 ]

2

[]

0

[ "2qgm", "2rad", "3b55", "6xcq", "6xcs" ]

5

[ "PUB00010533", "PUB00010534", "PUB00040938", "PUB00096158", "PUB00096159" ]

[ "3899861", "3523438", "16950397", "3326871", "22303981" ]

[ "Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli.", "Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II.", "Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.", "Origin and evolution of...

[ 1985, 1986, 2006, 1987, 2012 ]

5

[]

[ "IPR014622", "IPR016273" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 98, 8122, 726, 34 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Erythromycin esterase

Emycin_Estase

2

IPR007816

7,816

ResB-like domain

ResB-like_domain

Domain

13,499

false

This domain is found in a number of known and suspected cytochrome c biogenesis proteins, including ResB [ ]. Mutations in ResB indicate that they are essential for growth [ ]. ResB is predicted to be a transmembrane protein.

[]

0

[ "PFAM" ]

[ "PF05140" ]

[ "ResB" ]

[ 13499 ]

1

[ "GP" ]

[ "GenProp0680" ]

[ "GP:GenProp0680" ]

1

[ "7s9y", "7s9z" ]

2

[ "PUB00010215", "PUB00020239" ]

[ "10844653", "8631715" ]

[ "Genes required for cytochrome c synthesis in Bacillus subtilis.", "Regulators of aerobic and anaerobic respiration in Bacillus subtilis." ]

[ 2000, 1996 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured thaumarchaeote Rifle_16ft_4_minimus_1872" ]

[ 11977, 1210, 311, 1 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 5 ]

3

true

Domain

ResB-like domain

ResB-like_domain

1

IPR007817

7,817

Isocyanide synthase/Spore wall maturation protein DIT1

Isocyanide_synthase_DIT1

Family

3,435

false

Isocyanide synthases are required for the biosynthesis of isocyanides (or isonitriles), a class of microbial secondary metabolites that can be cytotoxic, antibacterial, and antiprotozoal [ ]. L-tyrosine isonitrile synthase from the Gammaproteobacteria Xenorhabdus nematophila participates in the biosynthesis of rhabdusc...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05141", "PTHR37285" ]

[ "DIT1_PvcA", "" ]

[ 3387, 3308 ]

2

[]

0

[ "3e59", "9dh4", "9dhm", "9dhn" ]

4

[ "PUB00010149", "PUB00010150", "PUB00090985", "PUB00100305", "PUB00100306" ]

[ "8183942", "8704959", "29844112", "24180436", "22711807" ]

[ "The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall.", "Novel pyoverdine biosynthesis gene(s) of Pseudomonas aeruginosa PAO.", "Fungal Isocyanide Synthases and Xanthocillin Biosynthesis ...

[ 1994, 1996, 2018, 2014, 2012 ]

5

[]

[ "IPR017133" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1069, 2361, 5 ]

3

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Isocyanide synthase/Spore wall maturation protein DIT1

Isocyanide_synthase_DIT1

5

IPR007818

7,818

SHI protein family

SHI

Family

3,720

false

This entry represents a group of plant proteins, including protein SHORT INTERNODES (SHI) and its paralogues from Arabidopsis. In Arabidopsis, the SHI family comprises ten members. They contain a RING finger-like zinc finger motif. SHI may act as a negative regulator of GA responses through transcriptional control bind...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR31604" ]

[ "" ]

[ 3720 ]

1

[]

0

[]

0

[ "PUB00083348", "PUB00099606" ]

[ "10368174", "30914468" ]

[ "The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein.", "OsSHI1 Regulates Plant Architecture Through Modulating the Transcriptional Activity of IPA1 in Rice." ]

[ 1999, 2019 ]

2

[]

0

null

[ "Bowmanella dokdonensis", "Streptophytina" ]

[ 1, 3719 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 45, 15, 27 ]

3

true

Family

SHI protein family

SHI

9

IPR007820

7,820

AbrB family

AbrB_fam

Family

9,148

false

AbrB is a multipass membrane protein [ ] that is probably involved in the regulation of alkylation damage induced protein AidB in Escherichia coli [ ].

[ "GO:0010468", "GO:0016020" ]

[ "regulation of gene expression", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05145", "PIRSF038991", "PTHR38457" ]

[ "AbrB", "Protein_AbrB", "" ]

[ 9148, 8256, 9078 ]

3

[]

0

[]

0

[ "PUB00019141", "PUB00042652" ]

[ "8002588", "15919996" ]

[ "Induction of the Escherichia coli aidB gene under oxygen-limiting conditions requires a functional rpoS (katF) gene.", "Global topology analysis of the Escherichia coli inner membrane proteome." ]

[ 1994, 2005 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9054, 14, 80 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

AbrB family

AbrB_fam

3

IPR007823

7,823

Ribosomal RNA processing protein 8

RRP8

Family

4,639

false

Ribosomal RNA processing protein 8 (Rrp8) is a nucleolar Rossman-fold like methyltransferase. In yeast, it is involved in pre-rRNA cleavage at site A2 [ ] and is responsible for a base methylation of the 25S rRNA [ ]. In humans it is also known as nucleomethylin (NML), and it is important for mediating the assembly of ...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05148", "PTHR12787" ]

[ "Methyltransf_8", "" ]

[ 4622, 4532 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

152

[ "2zfu" ]

1

[ "PUB00050320", "PUB00078606", "PUB00078607", "PUB00078608" ]

[ "18485871", "23180764", "10864042", "23897426" ]

[ "Epigenetic control of rDNA loci in response to intracellular energy status.", "Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.", "Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2.", "Regulation of SirT1-...

[ 2008, 2013, 2000, 2013 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "viral metagenome" ]

[ 4, 33, 4598, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 3, 1, 3, 3, 1, 3, 7, 1, 1, 6 ]

12

true

Family

Ribosomal RNA processing protein 8

RRP8

4

IPR007824

7,824

Paraflagellar rod

Flagellar_rod

Family

425

false

This family consists of several eukaryotic paraflagellar rod component proteins. The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains more than 250 proteins [ ]. In addition to its locomotive role, the flagellum is probably involved in nutrient uptake ...

[ "GO:0005516", "GO:0031514" ]

[ "calmodulin binding", "motile cilium" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05149" ]

[ "Flagellar_rod" ]

[ 425 ]

1

[]

0

[]

0

[ "PUB00010161", "PUB00010162" ]

[ "11112698", "11163437" ]

[ "Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei.", "Characterization and disruption of a new Trypanosoma brucei repetitive flagellum protein, using double-stranded RNA inhibition." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 425 ]

1

[]

0

true

Family

Paraflagellar rod

Flagellar_rod

9

IPR007825

7,825

Major outer membrane precursor, Legionella pneumophila-type

Major_OMP_Legionella

Family

1,128

false

This family consists of major outer membrane protein precursors from Legionella pneumophila and other bacteria.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05150", "PIRSF011407" ]

[ "Legionella_OMP", "Major_OMP_Legionella" ]

[ 1128, 70 ]

2

[]

0

[ "9nh1" ]

1

[]

0

[]

0

null

[ "Bacteria", "Durusdinium trenchii", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 1102, 1, 24, 1 ]

4

[]

0

true

Family

Major outer membrane precursor, Legionella pneumophila-type

Major_OMP_Legionella

5

IPR007826

7,826

Photosystem II PsbM

PSII_PsbM

Family

14,444

false

This entry represents the low molecular weight transmembrane protein PsbM found in PSII. PsbM is one of the most hydrophobic proteins in the thylakoid membrane. The function of this protein is unknown. Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria ...

[ "GO:0015979", "GO:0019684", "GO:0009523", "GO:0016020" ]

[ "photosynthesis", "photosynthesis, light reaction", "photosystem II", "membrane" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_00438", "PF05151", "PTHR35774", "TIGR03038" ]

[ "PSII_PsbM", "PsbM", "", "PS_II_psbM" ]

[ 13295, 14388, 13803, 14189 ]

4

[ "GP" ]

[ "GenProp0661" ]

[ "GP:GenProp0661" ]

1

[ "1s5l", "2axt", "3a0b", "3a0h", "3jcu", "3kzi", "3wu2", "4fby", "4il6", "4ixq", "4ixr", "4pbu", "4pj0", "4rvy", "4tnh", "4tni", "4tnj", "4tnk", "4ub6", "4ub8", "4v62", "4v82", "4yuu", "5b5e", "5b66", "5e79", "5e7c", "5gth", "5gti", "5kaf", "5kai", "5mdx"...

161

[ "PUB00015357", "PUB00015358", "PUB00015359", "PUB00097583", "PUB00152828" ]

[ "12518057", "15100025", "14871485", "30076221", "33846594" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement of photosystem 2.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "Thylakoid membrane lipid sulfoquinov...

[ 2003, 2004, 2004, 2018, 2021 ]

5

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 318, 14126 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 4, 2 ]

3

true

Family

Photosystem II PsbM

PSII_PsbM

5

IPR007827

7,827

Protein of unknown function DUF694

DUF705

Family

235

false

This family contains uncharacterised baculoviral proteins.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05152", "TIGR01684" ]

[ "DUF705", "viral_ppase" ]

[ 235, 157 ]

2

[]

0

[ "8i8b", "8vwi", "8vwj", "9h2a", "9h2b" ]

5

[]

0

[]

0

null

[ "Arthropoda", "Bacteria", "Viruses" ]

[ 12, 52, 171 ]

3

[]

0

true

Family

Protein of unknown function DUF694

DUF705

4

IPR007828

7,828

Inositol oxygenase

Inositol_oxygenase

Family

6,266

false

Inositol oxygenase ( ) is involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. It may be also involved in plant ascorbate biosynthesis [ , ].

[ "GO:0005506", "GO:0050113", "GO:0019310", "GO:0005737" ]

[ "iron ion binding", "inositol oxygenase activity", "inositol catabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05153", "PTHR12588" ]

[ "MIOX", "" ]

[ 6259, 6099 ]

2

[ "EC", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.99.1", "GenProp1347", "PWY-4841", "PWY-8142", "R-BTA-1855183", "R-DDI-1855183", "R-DRE-1855183", "R-HSA-1855183", "R-MMU-1855183", "R-RNO-1855183" ]

[ "EC:1.13.99.1", "GP:GenProp1347", "METACYC:PWY-4841", "METACYC:PWY-8142", "REACTOME:R-BTA-1855183", "REACTOME:R-DDI-1855183", "REACTOME:R-DRE-1855183", "REACTOME:R-HSA-1855183", "REACTOME:R-MMU-1855183", "REACTOME:R-RNO-1855183" ]

10

[ "2huo", "2ibn", "3bxd" ]

3

[ "PUB00053850", "PUB00053851" ]

[ "15660207", "14976233" ]

[ "The inositol oxygenase gene family of Arabidopsis is involved in the biosynthesis of nucleotide sugar precursors for cell-wall matrix polysaccharides.", "myo-inositol oxygenase offers a possible entry point into plant ascorbate biosynthesis." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 643, 5594, 8, 21 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 25, 1, 2, 2, 3, 2, 1, 4, 5, 5 ]

10

true

Family

Inositol oxygenase

Inositol_oxygenase

6

IPR007829

7,829

TM2 domain

TM2

Domain

18,514

false

This domain is composed of a pair of transmembrane α helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.

[]

0

[ "PFAM" ]

[ "PF05154" ]

[ "TM2" ]

[ 18514 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 87, 11237, 6996, 55, 139 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 6, 7, 6, 10 ]

6

true

Domain

TM2 domain

TM2

4

IPR007831

7,831

Type II secretion system protein GspE, N-terminal

T2SS_GspE_N

Domain

24,170

false

This domain is found at the N-terminal of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminal of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [ , , ], which modulates the activity of the respective protein. T...

[]

0

[ "PFAM" ]

[ "PF05157" ]

[ "MshEN" ]

[ 24170 ]

1

[]

0

[ "2d27", "2d28", "3jc8", "5htl", "5tsg", "5tsh", "5zfr", "6ejf", "6f8l", "6olj", "7lkm", "7lkn", "7lko", "8pdk", "8pe0", "8pfa", "8pkz", "8pqu", "9g1w", "9gl5", "9glg" ]

21

[ "PUB00010165", "PUB00033663", "PUB00033664", "PUB00104722", "PUB00106044", "PUB00151574" ]

[ "11073903", "15843017", "16162504", "34903052", "34903045", "27578558" ]

[ "Developmental aggregation of Myxococcus xanthus requires frgA, an frz-related gene.", "The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae.", "Structure and function of the XpsE N-terminal domain, an essential...

[ 2000, 2005, 2005, 2021, 2021, 2016 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 23599, 43, 2, 526 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Type II secretion system protein GspE, N-terminal

T2SS_GspE_N

6

IPR007832

7,832

RNA polymerase Rpc34

RNA_pol_Rpc34

Family

4,815

false

The family comprises a subunit specific to RNA Pol III, the tRNA specific polymerase. The C34 subunit of Saccharomyces cerevisiae RNA Pol III is part of a subcomplex of three subunits which have no counterpart in the other two nuclear RNA polymerases. This subunit interacts with TFIIIB70 and therefore participates in P...

[ "GO:0006383", "GO:0005666" ]

[ "transcription by RNA polymerase III", "RNA polymerase III complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF05158", "PIRSF028763" ]

[ "RNA_pol_Rpc34", "RNA_pol_Rpc34" ]

[ 4813, 3108 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-76061", "R-DDI-76066", "R-DME-76061", "R-DME-76066", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071", "R-SCE-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-DDI-76061", "REACTOME:R-DDI-76066", "REACTOME:R-DME-76061", "REACTOME:R-DME-76066", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-76061", "...

17

[ "2dk5", "2dk8", "2yu3", "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7ast", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l"...

57

[ "PUB00010211" ]

[ "9312031" ]

[ "Dual role of the C34 subunit of RNA polymerase III in transcription initiation." ]

[ 1997 ]

1

[ "IPR016049" ]

[]

1

0

1

[ "Eukaryota", "Sulfolobaceae" ]

[ 4810, 5 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 2, 13, 3, 1, 2, 5, 1, 1, 7 ]

12

true

Family

RNA polymerase Rpc34

RNA_pol_Rpc34

5

IPR007833

7,833

Capsule polysaccharide biosynthesis

Capsule_polysaccharide_synth

Family

7,594

false

This family includes export proteins involved in capsule polysaccharide biosynthesis, such as KpsS and LipB . Capsule polysaccharide modification protein lipB/A is involved in the phospholipid modification of the capsular polysaccharide and is a strong requirement for its translocation to the cell surface. The capsule ...

[ "GO:0000271", "GO:0015774" ]

[ "polysaccharide biosynthetic process", "polysaccharide transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF05159" ]

[ "Capsule_synth" ]

[ 7594 ]

1

[]

0

[ "5fa0", "5fa1", "6mgb", "6mgc", "6mgd", "8csb", "8csc", "8csd", "8cse", "8csf", "8fuw", "8fux" ]

12

[ "PUB00044063", "PUB00044064", "PUB00044065" ]

[ "15731047", "18430142", "17028279" ]

[ "Translocation and surface expression of lipidated serogroup B capsular Polysaccharide in Neisseria meningitidis.", "Identification and characterization of KpsS, a novel polysaccharide sulphotransferase in Mesorhizobium loti.", "Mesorhizobium loti produces nodPQ-dependent sulfated cell surface polysaccharides."...

[ 2005, 2008, 2006 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 66, 7420, 12, 96 ]

4

[]

0

true

Family

Capsule polysaccharide biosynthesis

Capsule_polysaccharide_synth

3

IPR007834

7,834

DSS1/SEM1

DSS1_SEM1

Family

4,140

false

This family includes yeast Sem1 and its mammalian homologue, DSS1. Sem1/DSS1 (also known as rpn15) is a component of lid subcomplex of 26S proteasome regulatory subunit [ , , ]. Besides being a subunit of the 26S proteasome, Sem1/DSS1 associates with other protein complexes [ ]. It is a component of the nuclear pore co...

[ "GO:0006406", "GO:0043248", "GO:0008541" ]

[ "mRNA export from nucleus", "proteasome assembly", "proteasome regulatory particle, lid subcomplex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER", "SMART" ]

[ "PF05160", "PTHR16771", "SM01385" ]

[ "DSS1_SEM1", "", "DSS1_SEM1" ]

[ 4074, 3828, 4108 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2012", "R-DME-209360", "R-DME-209406", "R-DME-209461", "R-DME-216167", "R-DME-432395", "R-DME-432524", "R-DME-432626", "R-DME-538864", "R-HSA-1169091", "R-HSA-1234176", "R-HSA-1236974", "R-HSA-1236978", "R-HSA-174084", "R-HSA-174113", "R-HSA-174154", "R-HSA-174178", "R-HSA-...

[ "GP:GenProp2012", "REACTOME:R-DME-209360", "REACTOME:R-DME-209406", "REACTOME:R-DME-209461", "REACTOME:R-DME-216167", "REACTOME:R-DME-432395", "REACTOME:R-DME-432524", "REACTOME:R-DME-432626", "REACTOME:R-DME-538864", "REACTOME:R-HSA-1169091", "REACTOME:R-HSA-1234176", "REACTOME:R-HSA-1236974"...

82

[ "1iyj", "1miu", "1mje", "3jck", "3jco", "3jcp", "3t5v", "3t5x", "4cr2", "4cr3", "4cr4", "4trq", "5a5b", "5g5p", "5gjq", "5gjr", "5l3t", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5ubp", "5vfp", "5vfq"...

132

[ "PUB00010536", "PUB00078011", "PUB00078012", "PUB00078013", "PUB00078014", "PUB00078015", "PUB00078016", "PUB00083352" ]

[ "8782053", "23643786", "19289793", "24412063", "15117943", "24896180", "26456823", "26944332" ]

[ "Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3.", "Localization of the regulatory particle subunit Sem1 in the 26S proteasome.", "Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery....

[ 1996, 2013, 2009, 2014, 2004, 2014, 2015, 2016 ]

8

[]

0

null

[ "Eukaryota", "Shewanella electrica" ]

[ 4139, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 1, 11, 2, 1, 5, 2, 1, 1, 6 ]

12

true

Family

DSS1/SEM1

DSS1_SEM1

9

IPR007835

7,835

MOFRL domain

MOFRL

Domain

8,604

false

The MOFRL(multi-organism fragment with rich Leucine) domain is found in bacteria and eukaryotes. The function of this domain is not clear, although it exists in some putative enzymes such as reductases and kinases.

[]

0

[ "PFAM" ]

[ "PF05161" ]

[ "MOFRL" ]

[ 8604 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "R-BTA-70350", "R-CEL-70350", "R-DME-70350", "R-DRE-70350", "R-HSA-70350", "R-MMU-70350", "R-RNO-70350" ]

[ "EC:2.7.1", "REACTOME:R-BTA-70350", "REACTOME:R-CEL-70350", "REACTOME:R-DME-70350", "REACTOME:R-DRE-70350", "REACTOME:R-HSA-70350", "REACTOME:R-MMU-70350", "REACTOME:R-RNO-70350" ]

8

[ "1x3l", "2b8n" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 634, 6156, 1683, 131 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 47, 2, 1, 3, 2 ]

6

true

Domain

MOFRL domain

MOFRL

7

IPR007836

7,836

Large ribosomal subunit protein eS32

Ribosomal_eS32

Family

759

false

This entry represents the large ribosomal subunit protein eS32 (previously known as eL41), which associates with the ribonucleoprotein particles of the 60S subunit late in the ribosomal maturation process. eS32 is encoded by the smallest known open reading frame and in yeast is composed of only 24 amino acids, 17 of wh...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05162" ]

[ "Ribosomal_L41" ]

[ 759 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-6791226", "R-HSA-72689", "R-HSA-72706", "R-HSA-72764", "R-HSA-9010553", "R-HSA-9633012", "R-HSA-975956", "R-HSA-975957" ]

[ "REACTOME:R-HSA-156827", "REACTOME:R-HSA-156902", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-192823", "REACTOME:R-HSA-2408557", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-72689", "REACTOME:R-HSA-72706", "REACTOME:R-HSA-72764", "REACTOME:R-HSA-9010553", "REACTOME:R-HSA-9633012", "REACTOME:R-HSA-9...

13

[ "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4d5y", "4d67", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y"...

495

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Cuniculiplasma divulgatum", "Eukaryota", "viral metagenome" ]

[ 1, 751, 7 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 3, 1, 1, 4, 1, 2, 2, 2 ]

12

true

Family

Large ribosomal subunit protein eS32

Ribosomal_eS32

1

IPR007837

7,837

DNA damage-inducible protein DinB

DinB

Family

14,859

false

This entry represents the DinB family, and includes DinB from Bacillus subtilis. DNA damage-inducible genes (dinA, dinB, and dinC) in Bacillus subtilis are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05163", "PTHR37302" ]

[ "DinB", "" ]

[ 14781, 9142 ]

2

[]

0

[ "2f22", "2qe9", "3di5", "3dka", "3gor", "6iz2" ]

6

[ "PUB00010154" ]

[ "1847907" ]

[ "Cloning and characterization of DNA damage-inducible promoter regions from Bacillus subtilis." ]

[ 1991 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 37, 14603, 111, 108 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

DNA damage-inducible protein DinB

DinB

4

IPR007838

7,838

Cell division protein ZapA-like

Cell_div_ZapA-like

Family

16,104

false

This entry represents a structural domain found in the cell division protein ZapA, as well as in related proteins. This domain has a core structure consisting of two layers alpha/beta, and has a long C-terminal helix that forms dimeric parallel and tetrameric antiparallel coiled coils [ ]. ZapA interacts with FtsZ, whe...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05164", "PTHR34981" ]

[ "ZapA", "" ]

[ 16082, 9791 ]

2

[]

0

[ "1t3u", "1w2e", "2mmv", "3hnw", "4p1m", "9isj", "9isk" ]

7

[ "PUB00021077" ]

[ "15288790" ]

[ "The crystal structure of ZapA and its modulation of FtsZ polymerisation." ]

[ 2004 ]

1

[]

[ "IPR023688", "IPR023771" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_76_C12" ]

[ 15824, 19, 260, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cell division protein ZapA-like

Cell_div_ZapA-like

1

IPR007839

7,839

GTP cyclohydrolase III

GTP_CycHdrlase_3

Family

747

false

GTP cyclohydrolase (GCH) III from Methanocaldococcus jannaschi catalyses the conversion of GTP to 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (FAPy). The reaction requires two bound magnesium ions for the catalysis and is activated by monovalent cations such as potassium and ammonium. The enzym...

[ "GO:0043740", "GO:0009058" ]

[ "GTP cyclohydrolase IIa activity", "biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_00608", "PF05165", "PIRSF009265", "PTHR42202" ]

[ "GTP_cyclohydro_3", "GCH_III", "GTP_cyclohydro_3", "" ]

[ 614, 747, 617, 631 ]

4

[ "EC", "METACYC" ]

[ "3.5.4.29", "PWY-6167" ]

[ "EC:3.5.4.29", "METACYC:PWY-6167" ]

2

[ "2qv6" ]

1

[ "PUB00049158" ]

[ "18052207" ]

[ "A new use for a familiar fold: the X-ray crystal structure of GTP-bound GTP cyclohydrolase III from Methanocaldococcus jannaschii reveals a two metal ion catalytic mechanism." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacillati", "ecological metagenomes" ]

[ 623, 115, 9 ]

3

[]

0

true

Family

GTP cyclohydrolase III

GTP_CycHdrlase_3

8

IPR007841

7,841

Uncharacterised protein family UPF0210

UPF0210

Family

4,788

false

The proteins in this family are functionally uncharacterised. The proteins are around 450 amino acids long and includes Streptococcus pneumoniae Sp0239 ( ) and similar uncharacterised proteins. Sp0239 is structurally similar to ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL), which are believed to have ...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PANTHER", "CDD" ]

[ "MF_01221", "NF003700", "PF05167", "PTHR37560", "cd08025" ]

[ "UPF0210", "PRK05313.1", "DUF711", "", "RNR_PFL_like_DUF711" ]

[ 3905, 4060, 4787, 4754, 3973 ]

5

[]

0

[ "2ha9" ]

1

[]

0

[]

[ "IPR014537" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 346, 4247, 118, 77 ]

4

[]

0

true

Family

Uncharacterised protein family UPF0210

UPF0210

9

IPR007842

7,842

HEPN domain

HEPN_dom

Domain

11,135

false

The HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain is a region of 110 residues found in the C terminus of sacsin, a chaperonin implicated in an early-onset neurodegenerative disease in human, and in many bacterial and archeabacterial proteins. There are three classes of proteins with HEPN domain: Si...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05168", "PS50910", "SM00748" ]

[ "HEPN", "HEPN", "HEPN" ]

[ 10971, 7003, 6556 ]

3

[ "PROSITEDOC" ]

[ "PDOC50910" ]

[ "PROSITEDOC:PDOC50910" ]

1

[ "1o3u", "1ufb", "1wol", "2hsb", "3o10", "4nqf", "9min" ]

7

[ "PUB00011826" ]

[ "12765831" ]

[ "HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 1597, 7068, 2183, 2, 285 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 2, 5 ]

4

true

Domain

HEPN domain

HEPN_dom

4

IPR007844

7,844

AsmA

Domain

16,939

false

The AsmA protein is involved in the assembly of outer membrane proteins in Escherichia coli [ ]. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant [ ]. AsmA may have a role in LPS biogenesis [ ].

[]

0

[ "PFAM" ]

[ "PF05170" ]

[ "AsmA" ]

[ 16939 ]

1

[]

0

[]

0

[ "PUB00010140", "PUB00010141" ]

[ "8866482", "7476172" ]

[ "Examination of AsmA and its effect on the assembly of Escherichia coli outer membrane proteins.", "Molecular analysis of asmA, a locus identified as the suppressor of OmpF assembly mutants of Escherichia coli K-12." ]

[ 1996, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16749, 26, 164 ]

3

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

AsmA

9

IPR007845

7,845

Haemin-degrading HemS/ChuX domain

HemS/ChuX_dom

Domain

3,857

false

The Yersinia enterocolitica O:8 periplasmic binding protein-dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS. The structure for HemS has been solved and con...

[ "GO:0006826" ]

[ "iron ion transport" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05171" ]

[ "HemS" ]

[ 3857 ]

1

[]

0

[ "1u9t", "2j0p", "2j0r", "4cdp", "4imh", "4mf9", "4mgf", "7qxv" ]

8

[ "PUB00019676" ]

[ "7997183" ]

[ "Transport of haemin across the cytoplasmic membrane through a haemin-specific periplasmic binding-protein-dependent transport system in Yersinia enterocolitica." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3831, 2, 24 ]

3

[]

0

true

Domain

Haemin-degrading HemS/ChuX domain

HemS/ChuX_dom

3

IPR007846

7,846

RNA-recognition motif (RRM) Nup35-type domain

RRM_NUP35_dom

Domain

3,495

false

The nuclear pore complex (NPC) mediates the transport of macromolecules across the nuclear envelope (NE). The NPC is composed of a relatively small number of proteins (~30), termed nucleoporins or Nups. The vertebrate nuclear pore protein Nup35, the ortholog of Saccharomyces cerevisiae Nup53p, is suggested to interact ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05172", "PS51472" ]

[ "RRM_Nup35", "RRM_NUP35" ]

[ 3462, 3368 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-DME-9615933", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-D...

97

[ "1wwh", "2m4m", "3p3d", "4lir", "5uaz", "7n85", "7n9f", "7r5j", "7r5k", "7tbj", "7tbk", "7tbl", "7tbm", "8ozb", "8tj5", "9hcj" ]

16

[ "PUB00038167" ]

[ "16962612" ]

[ "The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain." ]

[ 2006 ]

1

[ "IPR000504" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3495 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 3, 1, 2, 2, 2, 1, 5, 5, 2, 1, 13 ]

11

true

Domain

RNA-recognition motif (RRM) Nup35-type domain

RRM_NUP35_dom

1

IPR007849

7,849

ATPase assembly factor ATP10

ATP10

Family

2,950

false

This entry includes ATPase complex subunit ATP10, mostly from yeasts and plants. In budding yeasts, ATP10 is a mitochondria protein that is essential for the assembly of the mitochondrial F1-F0 complex [ ]. It assists assembly of Atp6 into the F0 unit of the yeast mitochondrial ATPase [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05176", "PTHR28106" ]

[ "ATP-synt_10", "" ]

[ 2783, 2889 ]

2

[]

0

[]

0

[ "PUB00010138", "PUB00072355" ]

[ "2141026", "14998992" ]

[ "ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex.", "Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase." ]

[ 1990, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "freshwater metagenome" ]

[ 97, 2808, 44, 1 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 2, 1, 1, 9 ]

6

true

Family

ATPase assembly factor ATP10

ATP10

7

IPR007852

7,852

Cdc73/Parafibromin

Family

5,068

false

This entry includes Cdc73 from budding yeasts and its animal homologue, parafibromin. They are part of the Paf1 complex involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [ ]. In budding yeasts, Paf1 is an RNA polymerase II-associated p...

[ "GO:0006368", "GO:0016593" ]

[ "transcription elongation by RNA polymerase II", "Cdc73/Paf1 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12466" ]

[ "" ]

[ 5068 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-112382", "R-CEL-201722", "R-CEL-674695", "R-CEL-75955", "R-GGA-201722", "R-GGA-5632684", "R-GGA-674695", "R-GGA-75955", "R-HSA-112382", "R-HSA-201722", "R-HSA-5632684", "R-HSA-674695", "R-HSA-75955", "R-HSA-8866654", "R-MMU-112382", "R-MMU-201722", "R-MMU-5632684", "R-MMU-67...

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-201722", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-75955", "REACTOME:R-GGA-201722", "REACTOME:R-GGA-5632684", "REACTOME:R-GGA-674695", "REACTOME:R-GGA-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-201722", "REACTOME:R-HSA-5632684", "REACTOME:R-HSA-674...

26

[ "3v46", "4dm4", "5yde", "5ydf", "6ted", "7oop", "7opc", "7opd", "7unc", "7und", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "8a3y", "9egx", "9egy", "9egz", "9eh0", "9eh2", "9hvq", "9rtt", "9s0u", "9s3g" ]

27

[ "PUB00010537", "PUB00074568", "PUB00074591", "PUB00074592" ]

[ "12242279", "20178742", "20363855", "20463090" ]

[ "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.", "The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.", "PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regul...

[ 2002, 2010, 2010, 2010 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5068 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 3, 11, 1, 1, 3, 4, 1, 1, 3 ]

12

true

Family

Cdc73/Parafibromin

1

IPR007853

7,853

Zinc finger, DNL-type

Znf_DNL-typ

Domain

5,260

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05180", "PS51501" ]

[ "zf-DNL", "ZF_DNL" ]

[ 5228, 5231 ]

2

[]

0

[ "2e2z" ]

1

[ "PUB00014077", "PUB00017068", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00047324", "PUB00055517" ]

[ "12665246", "15383543", "17210253", "15963892", "15718139", "10529348", "11179890", "17571076", "15642367" ]

[ "Zinc fingers--folds for many occasions.", "Zim17, a novel zinc finger protein essential for protein import into mitochondria.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zin...

[ 2002, 2004, 2007, 2005, 2005, 1999, 2001, 2007, 2005 ]

9

[]

0

null

[ "Eukaryota", "Pseudomonadota", "hydrothermal vent metagenome" ]

[ 5255, 4, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 1, 3, 1, 1, 1, 6, 2, 1, 1, 17 ]

12

true

Domain

Zinc finger, DNL-type

Znf_DNL-typ

7

IPR007855

7,855

RNA-dependent RNA polymerase

RDRP

Family

13,201

false

This entry also includes QDE-1 from the filamentous fungus Neurospora. QDE-1 is both an RdRP and a DNA-dependent RNA polymerase (DdRP). It is able to synthesize RNA from both ssRNA and single-stranded DNA (ssDNA) [ ]. RNA dependent RNA polymerases (RDRP) enzymes (RDRP; ) are involved in the amplification of regulatory ...

[ "GO:0003968" ]

[ "RNA-directed RNA polymerase activity" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR23079" ]

[ "" ]

[ 13201 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "2j7n", "2j7o", "5fsw", "7eu0", "7eu1", "7roz", "7rqs", "7w82", "7w84", "7w88", "7y7p", "7y7q", "7y7r", "7y7s", "7y7t", "8xmb", "8xmc", "8xmd", "8xme" ]

19

[ "PUB00016353", "PUB00035781", "PUB00092792" ]

[ "12553882", "16691418", "20957187" ]

[ "Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases.", "On the origin and functions of RNA-mediated silencing: from protists to man.", "The DNA/RNA-dependent RNA polymerase QDE-1 generates aberran...

[ 2003, 2006, 2010 ]

3

[]

0

null

[ "Bacillota", "Eukaryota", "Siphoviridae sp. ctGa111" ]

[ 10, 13190, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 41, 5, 3, 15, 1, 52 ]

6

true

Family

RNA-dependent RNA polymerase

RDRP

2

IPR007856

7,856

Saposin-like type B, region 1

SapB_1

Domain

9,077

false

Synonym(s):cerebroside sulphate activator, CSAct Saposin B is a small non-enzymatic glycoprotein required for the breakdown of cerebroside sulphates (sulphatides) in lysosomes. Saposin B contains three intramolecular disulphide bridges, exists as a dimer and is remarkably heat, protease, and pH stable. The crystal stru...

[ "GO:0006629" ]

[ "lipid metabolic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05184" ]

[ "SapB_1" ]

[ 9077 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-9840310", "R-DDI-9840310", "R-HSA-114608", "R-HSA-375276", "R-HSA-418594", "R-HSA-5683826", "R-HSA-5688031", "R-HSA-5688849", "R-HSA-5688890", "R-HSA-6798695", "R-HSA-9840310", "R-MMU-114608", "R-MMU-375276", "R-MMU-418594", "R-MMU-5683826", "R-MMU-6798695", "R-MMU-9840310", ...

[ "REACTOME:R-CEL-9840310", "REACTOME:R-DDI-9840310", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-5688031", "REACTOME:R-HSA-5688849", "REACTOME:R-HSA-5688890", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9840310", "REACTOME:R...

23

[ "1m12", "1nkl", "1qdm", "1sn6", "2dob", "2gtg", "2qyp", "2r0r", "2r1q", "2rb3", "2z9a", "3bqp", "3bqq", "3rfi", "4ddj", "4uex", "5nxb", "5u85", "6vyn", "6vzd", "6w1b", "7mbk", "7p4t", "8equ", "9i63" ]

25

[ "PUB00010538" ]

[ "12518053" ]

[ "Crystal structure of saposin B reveals a dimeric shell for lipid binding." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Kangiella spongicola", "viral metagenome" ]

[ 9075, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 26, 2, 9, 4, 12, 28, 25, 18, 104 ]

9

true

Domain

Saposin-like type B, region 1

SapB_1

9

IPR007857

7,857

Protein arginine N-methyltransferase PRMT5

Arg_MeTrfase_PRMT5

Family

4,058

false

This entry represents a group of arginine N-methyltransferases, including Skb1 from S. pombe [ ], Hsl7 from S. cerevisiae [ ] and their homologues PRMT5 from animals [ , , ] and plants [ ]. Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe [ ]. Plant PMRT15 is involved in the post-transcri...

[ "GO:0008168", "GO:0006479", "GO:0035246" ]

[ "methyltransferase activity", "protein methylation", "peptidyl-arginine N-methylation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF015894" ]

[ "Skb1_MeTrfase" ]

[ 4058 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.320", "R-DDI-3214858", "R-DME-3214858", "R-HSA-191859", "R-HSA-3214858", "R-HSA-6804760", "R-MMU-191859", "R-MMU-3214858", "R-MMU-6804760", "R-SPO-3214858" ]

[ "EC:2.1.1.320", "REACTOME:R-DDI-3214858", "REACTOME:R-DME-3214858", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-3214858", "REACTOME:R-HSA-6804760", "REACTOME:R-MMU-191859", "REACTOME:R-MMU-3214858", "REACTOME:R-MMU-6804760", "REACTOME:R-SPO-3214858" ]

10

[ "3ua3", "3ua4", "4g56", "4gqb", "4x60", "4x61", "4x63", "5c9z", "5emj", "5emk", "5eml", "5emm", "5fa5", "6ckc", "6k1s", "6rll", "6rlq", "6ugh", "6uxx", "6uxy", "6v0n", "6v0o", "6v0p", "7bo7", "7kib", "7kic", "7kid", "7l1g", "7m05", "7mx7", "7mxa", "7mxc"...

86

[ "PUB00010228", "PUB00020182", "PUB00058186", "PUB00073546", "PUB00073547", "PUB00073549", "PUB00073550", "PUB00073551" ]

[ "10531356", "11152681", "17709427", "11278267", "10903903", "17363895", "20962777", "22269951" ]

[ "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.", "Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.", "Two distinct arginine methyltransferases are required for biogenes...

[ 1999, 2001, 2007, 2001, 2000, 2007, 2010, 2012 ]

8

[ "IPR025799" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4058 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 1, 2, 3, 2, 2, 2, 4, 1, 11 ]

11

true

Family

Protein arginine N-methyltransferase PRMT5

Arg_MeTrfase_PRMT5

5

IPR007858

7,858

Dpy-30 motif

Dpy-30_motif

Conserved_site

9,200

false

This motif is about 40 residues long and is probably formed of two α-helices. It is found in the Dpy-30 proteins, hence the motifs name. Dpy-30 from Caenorhabditis elegans is an essential component of dosage compensation machinery and loss of dpy-30 activity results in XX-specific lethality; in XO animals, Dpy-30 is re...

[]

0

[ "PFAM" ]

[ "PF05186" ]

[ "Dpy-30" ]

[ 9200 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3214841", "R-HSA-499943", "R-HSA-5617472", "R-HSA-8936459", "R-HSA-9772755", "R-HSA-9818564", "R-HSA-9841922", "R-HSA-9944997", "R-MMU-499943" ]

[ "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-499943", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-9772755", "REACTOME:R-HSA-9818564", "REACTOME:R-HSA-9841922", "REACTOME:R-HSA-9944997", "REACTOME:R-MMU-499943" ]

9

[ "3g36", "4riq", "4rt4", "4rta", "6bx3", "6chg", "6e2h", "6pwv", "6ugm", "6uh5", "6ven", "7jrj", "7jtk", "7n6g", "7ud5", "8glv", "8j07", "8wzb", "8x2u", "9d2f", "9e5c", "9fqr", "9ijj", "9nw3" ]

24

[ "PUB00044078", "PUB00044079", "PUB00044080" ]

[ "11752412", "16260194", "7588066" ]

[ "A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.", "Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex.", "DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabdit...

[ 2002, 2005, 1995 ]

3

[]

0

null

[ "Eukaryota", "mine drainage metagenome" ]

[ 9199, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 4, 18, 6, 12, 9, 1, 14, 1, 1 ]

9

true

Conserved_site

Dpy-30 motif

Dpy-30_motif

6