LiteFold/InterPro · Datasets at Hugging Face

IPR007619

7,619

Herpesvirus U44

Herpes_U44

Family

174

false

This entry represents uncharacterised proteins from dsDNA beta-herpesvirinae and gamma-herpesvirinae viruses. They are named variously as U44, BSRF1, UL71, and M71. The entry also includes BSRF1.

[]

0

[ "PFAM" ]

[ "PF04533" ]

[ "Herpes_U44" ]

[ 174 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "6lqo" ]

1

[]

0

[]

0

null

[ "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 173 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus U44

Herpes_U44

8

IPR007620

7,620

Herpesvirus UL56

Herpes_UL56

Family

104

false

In herpes simplex virus type 2, UL56 is thought to be a tail-anchored type II membrane protein involved in vesicular trafficking. The C-terminal hydrophobic region is required for association with the cytoplasmic membrane, and the N-terminal proline-rich region is important for the translocation of UL56 to the Golgi ap...

[]

0

[ "PFAM" ]

[ "PF04534" ]

[ "Herpes_UL56" ]

[ 104 ]

1

[]

0

[]

0

[ "PUB00010040" ]

[ "12050385" ]

[ "Identification and characterization of the UL56 gene product of herpes simplex virus type 2." ]

[ 2002 ]

1

[]

0

null

[ "Simplexvirus" ]

[ 104 ]

1

[]

0

true

Family

Herpesvirus UL56

Herpes_UL56

9

IPR007621

7,621

TPM domain

TPM_dom

Domain

23,871

false

TPM domain is named after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold [ ]. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in...

[]

0

[ "PFAM" ]

[ "PF04536" ]

[ "TPM_phosphatase" ]

[ 23871 ]

1

[]

0

[ "2kpt", "2kw7", "2lt2", "2mpb", "3ptj", "3pvh", "3pw9", "4oa3", "5anp", "7tbr", "8c7i", "9h70" ]

12

[ "PUB00056969", "PUB00057495", "PUB00078747", "PUB00078748" ]

[ "21908686", "17576201", "21653280", "22922783" ]

[ "Structural and Functional Assays of AtTLP18.3 Identify Its Novel Acid Phosphatase Activity in Thylakoid Lumen.", "TLP18.3, a novel thylakoid lumen protein regulating photosystem II repair cycle.", "The Psb32 protein aids in repairing photodamaged photosystem II in the cyanobacterium Synechocystis 6803.", "Po...

[ 2011, 2007, 2011, 2012 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 15, 22172, 1508, 3, 173 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 3, 6 ]

4

true

Domain

TPM domain

TPM_dom

4

IPR007622

7,622

Herpesvirus UL55

Herpes_UL55

Family

115

false

In infected cells, UL55 is associated with the nuclear matrix, and found adjacent to compartments containing the capsid protein ICP35. UL55 was not detected in assembled virions. It is thought that UL55 may play a role in virion assembly or maturation [ ].

[ "GO:0019058" ]

[ "viral life cycle" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04537" ]

[ "Herpes_UL55" ]

[ 115 ]

1

[]

0

[]

0

[ "PUB00010041" ]

[ "9714248" ]

[ "Characterization of the UL55 gene product of herpes simplex virus type 2." ]

[ 1998 ]

1

[]

0

null

[ "Alphaherpesvirinae", "Corallococcus aberystwythensis" ]

[ 114, 1 ]

2

[]

0

true

Family

Herpesvirus UL55

Herpes_UL55

8

IPR007623

7,623

Brain-expressed X-linked protein

BEX

Family

906

false

This family includes the brain-expressed X-liked proteins (which include)human p75NTR-associated cell death executor), which may be a signalling adaptor molecule involved in p75NTR-apoptosis induced by nerve growth factor. It may be important in neurogenetic diseases [ ].

[]

0

[ "PIRSF", "PANTHER", "PANTHER" ]

[ "PIRSF008633", "PTHR13987", "PTHR19430" ]

[ "BEX", "", "" ]

[ 708, 189, 717 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-205025", "R-HSA-205025", "R-MMU-205025", "R-RNO-205025" ]

[ "REACTOME:R-BTA-205025", "REACTOME:R-HSA-205025", "REACTOME:R-MMU-205025", "REACTOME:R-RNO-205025" ]

4

[]

0

[ "PUB00073473" ]

[ "16498402" ]

[ "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." ]

[ 2006 ]

1

[ "IPR021156" ]

[]

1

0

1

[ "Eutheria" ]

[ 906 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 6, 10 ]

3

true

Family

Brain-expressed X-linked protein

BEX

1

IPR007624

7,624

RNA polymerase sigma-70 region 3

RNA_pol_sigma70_r3

Domain

75,600

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003700", "GO:0006352", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF04539" ]

[ "Sigma70_r3" ]

[ 75600 ]

1

[]

0

[ "1iw7", "1ku2", "1l0o", "1l9u", "1l9z", "1rp3", "1sc5", "1smy", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "3dxj", "3eql", "3iyd", "3ugo", "3ugp", "3wod", "4g7h", "4g7o", "4g7z", "4jk1", "4jk2", "4jkr", "4ki2", "4kmu", "4kn4", "4kn7", "4ljz"...

337

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "11931761", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Structure of the bacterial RNA polymerase promoter specificity sigma subunit.", "...

[ 1988, 1992, 1986, 2002, 2015 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2, 70061, 4504, 19, 1014 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 3, 23, 44 ]

4

true

Domain

RNA polymerase sigma-70 region 3

RNA_pol_sigma70_r3

2

IPR007626

7,626

Herpesvirus viron egress-type

Herpesvirus_viron_egress-type

Family

423

false

During primary envelopment Human herpesvirus 1 (HHV-1, HSV-1) nucleocapsids translocate from the nucleus to the cytoplasm. Lining the inside of the INM is the nuclear lamina, which is composed of a meshwork of proteins with spaces too small for the capsid to move through without some disruption of the lamina. The lamin...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_04024", "PF04541" ]

[ "HSV_NEC2", "Herpes_U34" ]

[ 378, 423 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "4z3u", "4zxs", "5a3g", "5d5n", "5dob", "5e8c", "5fki", "6t3x", "6t3z", "7pab", "7t7i", "8g6d" ]

12

[ "PUB00008381", "PUB00035844", "PUB00053591", "PUB00053592" ]

[ "11507225", "15140953", "12805460", "15140956" ]

[ "U(L)31 and U(L)34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids.", "Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34.", "Effects of charged cluster mu...

[ 2001, 2004, 2003, 2004 ]

4

[]

0

null

[ "Herpesvirales", "Homo sapiens" ]

[ 422, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus viron egress-type

Herpesvirus_viron_egress-type

9

IPR007627

7,627

RNA polymerase sigma-70 region 2

RNA_pol_sigma70_r2

Domain

409,595

false

This entry represents region 2 of RNA polymerase sigma-70. Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase ...

[ "GO:0003700", "GO:0006352", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF04542" ]

[ "Sigma70_r2" ]

[ 409595 ]

1

[]

0

[ "1h3l", "1iw7", "1ku2", "1l0o", "1l9u", "1l9z", "1or7", "1rp3", "1sc5", "1sig", "1smy", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2mao", "2map", "2o7g", "2q1z", "2z2s", "3dxj", "3eql", "3iyd", "3les", "3lev", "3mzy", "3ugo", "3ugp", "3wod"...

386

[ "PUB00000061", "PUB00000942", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00088319" ]

[ "3052291", "8858155", "1597408", "3092189", "11931761", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "...

[ 1988, 1996, 1992, 1986, 2002, 2015 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 17, 399937, 5208, 333, 4100 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 22, 6, 23, 45 ]

4

true

Domain

RNA polymerase sigma-70 region 2

RNA_pol_sigma70_r2

5

IPR007629

7,629

Herpesvirus UL20, egress protein

Herpes_UL20

Family

162

false

UL20 is predicted to be a transmembrane protein with multiple membrane spans. It is involved in the trans-cellular transport of enveloped virions, and is therefore important for viral egress. However, UL20 operates in different cellular compartments and different stages of egress in Suid herpesvirus 1 (Pseudorabies vir...

[ "GO:0019058" ]

[ "viral life cycle" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04544" ]

[ "Herpes_UL20" ]

[ 162 ]

1

[]

0

[]

0

[ "PUB00010047" ]

[ "9188641" ]

[ "The UL20 gene product of pseudorabies virus functions in virus egress." ]

[ 1997 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 162 ]

1

[]

0

true

Family

Herpesvirus UL20, egress protein

Herpes_UL20

7

IPR007630

7,630

RNA polymerase sigma-70 region 4

RNA_pol_sigma70_r4

Domain

126,649

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003700", "GO:0006352", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF04545" ]

[ "Sigma70_r4" ]

[ 126649 ]

1

[]

0

[ "1iw7", "1ku3", "1ku7", "1l0o", "1l9u", "1l9z", "1rio", "1rp3", "1sc5", "1smy", "1tlh", "1tty", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2p7v", "2q1z", "2w48", "2z2s", "3dxj", "3eql", "3hug", "3iyd", "3n97", "3t72", "3wod", "4g6d", "4g7h"...

373

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "11931761", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Structure of the bacterial RNA polymerase promoter specificity sigma subunit.", "...

[ 1988, 1992, 1986, 2002, 2015 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 421, 119710, 4500, 295, 1723 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 4, 21, 38 ]

4

true

Domain

RNA polymerase sigma-70 region 4

RNA_pol_sigma70_r4

9

IPR007631

7,631

RNA polymerase sigma factor 70, non-essential domain

RNA_pol_sigma_70_non-ess

Domain

17,832

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "PFAM" ]

[ "PF04546" ]

[ "Sigma70_ner" ]

[ 17832 ]

1

[]

0

[ "1sig", "3iyd", "4jk1", "4jk2", "4jkr", "4kmu", "4kn4", "4kn7", "4ljz", "4lk0", "4lk1", "4llg", "4mex", "4mey", "4xsx", "4xsy", "4xsz", "4yfk", "4yfn", "4yfx", "4yg2", "4yln", "4ylo", "4ylp", "4zh2", "4zh3", "4zh4", "5uac", "5uag", "5uah", "5uaj", "5ual"...

117

[ "PUB00000061", "PUB00000942", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00088319" ]

[ "3052291", "8858155", "1597408", "3092189", "11931761", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "...

[ 1988, 1996, 1992, 1986, 2002, 2015 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Peduoviridae", "unclassified sequences" ]

[ 17660, 41, 2, 129 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RNA polymerase sigma factor 70, non-essential domain

RNA_pol_sigma_70_non-ess

8

IPR007632

7,632

Anoctamin

Family

28,396

false

This entry represents the anoctamin family, which includes anoctamin1-10 (Ano1-10 or TMEM16A-J); 7 members could be divided into two subfamilies, Ca(2+)-dependent Cl(-) channels (TMEM16A and 16B) and Ca(2+)-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J) [ , ]. This entry also includes anoctamin-like prot...

[]

0

[ "PANTHER" ]

[ "PTHR12308" ]

[ "" ]

[ 28396 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2672351", "R-DRE-2672351", "R-HSA-2672351", "R-HSA-381426", "R-HSA-381753", "R-HSA-6798695", "R-HSA-8957275", "R-HSA-9733458", "R-MMU-2672351", "R-MMU-381426", "R-MMU-6798695", "R-MMU-8957275", "R-RNO-2672351", "R-SCE-2672351", "R-SCE-6798695", "R-SPO-2672351", "R-SPO-6798695"...

[ "REACTOME:R-BTA-2672351", "REACTOME:R-DRE-2672351", "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-381753", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-9733458", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-6798695", "REACTOME:R...

17

[ "4wis", "4wit", "5nl2", "5oc9", "5oyb", "5oyg", "6bgi", "6bgj", "6dz7", "6e0h", "6e1o", "6oy3", "6p46", "6p47", "6p48", "6p49", "6qm4", "6qm5", "6qm6", "6qm9", "6qma", "6qmb", "6qp6", "6qpb", "6qpc", "6qpi", "6r65", "6r7x", "6r7y", "6r7z", "7b5c", "7b5d"...

70

[ "PUB00069342", "PUB00069343", "PUB00069344", "PUB00069345", "PUB00069346", "PUB00069347", "PUB00152621" ]

[ "18724360", "19474308", "15701790", "23532839", "17308099", "20056604", "25383531" ]

[ "TMEM16A confers receptor-activated calcium-dependent chloride conductance.", "TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.", "Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the v...

[ 2008, 2009, 2005, 2013, 2007, 2010, 2014 ]

7

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 28395, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 4, 74, 23, 49, 35, 1, 2, 57, 1, 1, 33 ]

12

true

Family

Anoctamin

9

IPR007633

7,633

Bacteriophage P2, Holin

Phage_P2_Holin

Family

873

false

This entry represents Holin from Bacteriophage P2 and similar proteins from tailed bacteriophages (Caudovirales) and prophages found in Proteobacteria. Holin determines the precise timing of host cell lysis [ ]. Holins form large oligomeric flexible pores in the cytoplasmic membranes of bacteria to allow the endolysins...

[ "GO:0044660" ]

[ "viral release via pore formation in host cell membrane" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04550" ]

[ "Phage_holin_3_2" ]

[ 873 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00010120", "PUB00100006", "PUB00105459" ]

[ "11459934", "23335412", "25157079" ]

[ "Holins kill without warning.", "Functional analysis of a class I holin, P2 Y.", "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications." ]

[ 2001, 2013, 2015 ]

3

[]

0

null

[ "Caudoviricetes", "Opisthokonta", "Pseudomonadati" ]

[ 49, 5, 819 ]

3

[]

0

true

Family

Bacteriophage P2, Holin

Phage_P2_Holin

1

IPR007634

7,634

RNA polymerase sigma factor 54, DNA-binding

RNA_pol_sigma_54_DNA-bd

Domain

17,343

false

This DNA-binding domain is based on peptide fragmentation data. This domain has a three-helical bundle (helix-turn-helix motif) with a strongly positive patch that binds DNA [ , ].

[ "GO:0001216" ]

[ "DNA-binding transcription activator activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04552" ]

[ "Sigma54_DBD" ]

[ 17343 ]

1

[]

0

[ "2ahq", "2mt3", "2o8k", "2o9l", "5nsr", "5nss", "5nwt", "5ui5", "5ui8", "6gfw", "6gh5", "6gh6", "7qv9", "7qwp", "7qxi", "8f1i", "8f1j", "8f1k", "8re4", "8rea", "8reb", "8rec", "8red", "8ree", "9mse", "9msf", "9msg", "9msh", "9msj", "9q90", "9q91", "9q92"...

38

[ "PUB00008721", "PUB00048281" ]

[ "10894718", "19426742" ]

[ "The bacterial enhancer-dependent sigma(54) (sigma(N)) transcription factor.", "Structure of the RNA polymerase core-binding domain of sigma(54) reveals a likely conformational fracture point." ]

[ 2000, 2009 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 17016, 26, 299 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RNA polymerase sigma factor 54, DNA-binding

RNA_pol_sigma_54_DNA-bd

9

IPR007635

7,635

Tis11B-like protein, N-terminal

Tis11B_N

Domain

1,379

false

All proteins of containing this domain also contain a tandem repeat of CCCH zinc fingers ( ). Tis11B, Tis11D and their homologues are thought to be regulatory proteins involved in the response to growth factors [ ]. Tis11B ( ) is thought to be involved in calcium signalling-induced apoptosis in B cells [ ]. The functio...

[]

0

[ "PFAM" ]

[ "PF04553" ]

[ "Tis11B_N" ]

[ 1379 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-450385", "R-HSA-9820841", "R-MMU-450385", "R-RNO-450385" ]

[ "REACTOME:R-HSA-450385", "REACTOME:R-HSA-9820841", "REACTOME:R-MMU-450385", "REACTOME:R-RNO-450385" ]

4

[]

0

[ "PUB00017050", "PUB00017051" ]

[ "1695727", "8898945" ]

[ "The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes.", "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36." ...

[ 1990, 1996 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1379 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 8, 5, 8 ]

4

true

Domain

Tis11B-like protein, N-terminal

Tis11B_N

9

IPR007636

7,636

Restriction endonuclease, type II, XhoI

Restrct_endonuc_II_XhoI

Family

438

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF" ]

[ "PF04555", "PIRSF000994" ]

[ "XhoI", "Restrict_endonuc_II_XhoI" ]

[ 438, 104 ]

2

[ "EC" ]

[ "3.1.21.4" ]

[ "EC:3.1.21.4" ]

1

[]

0

[ "PUB00017052", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "3001639", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Nucleotide sequence of the PaeR7 restriction/modification system and partial characterization of its protein products.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between ...

[ 1985, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Bacteria", "Stenosarchaea group", "ecological metagenomes" ]

[ 411, 14, 13 ]

3

[]

0

true

Family

Restriction endonuclease, type II, XhoI

Restrct_endonuc_II_XhoI

9

IPR007637

7,637

Restriction endonuclease, type II, DpnII-like

Restrct_endonuc_II_DpnII-like

Domain

844

false

This entry is found in type II restriction enzymes such as DpnII ( ), which recognises the double-stranded unmethylated sequence GATC and cleave before G-1 [ ], where it encompasess the full length of the protein. It is also found in a number of proteins of unknown function, where it is located adjacent to a DNA adenin...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF04556" ]

[ "DpnII" ]

[ 844 ]

1

[ "EC" ]

[ "3.1.21.4" ]

[ "EC:3.1.21.4" ]

1

[]

0

[ "PUB00010050", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "11133943", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different...

[ 2001, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 39, 776, 11, 17, 1 ]

5

[]

0

true

Domain

Restriction endonuclease, type II, DpnII-like

Restrct_endonuc_II_DpnII-like

3

IPR007638

7,638

Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2

Gln-tRNA-synth_Ib_RNA-bd_2

Domain

3,649

false

Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through a highly specific two-step reaction [ , ]. These enzymes vary widely in size and oligomeric state, and share limited sequence homology [ ]. The 20 aminoacyl-tRNA synth...

[ "GO:0000166", "GO:0004819", "GO:0005524", "GO:0006425", "GO:0005737" ]

[ "nucleotide binding", "glutamine-tRNA ligase activity", "ATP binding", "glutaminyl-tRNA aminoacylation", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF04557" ]

[ "tRNA_synt_1c_R2" ]

[ 3649 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.1.1.18", "R-BTA-9856649", "R-DDI-9856649", "R-DME-9856649", "R-HSA-2408522", "R-HSA-379716", "R-HSA-379726", "R-HSA-9856649", "R-MMU-9856649", "R-RNO-9856649" ]

[ "EC:6.1.1.18", "REACTOME:R-BTA-9856649", "REACTOME:R-DDI-9856649", "REACTOME:R-DME-9856649", "REACTOME:R-HSA-2408522", "REACTOME:R-HSA-379716", "REACTOME:R-HSA-379726", "REACTOME:R-HSA-9856649", "REACTOME:R-MMU-9856649", "REACTOME:R-RNO-9856649" ]

10

[ "3tl4", "4h3s", "4r3z", "4ye6", "4ye8", "4ye9", "8uk6" ]

7

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00010051", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10347214", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 1999, 2000, 2002 ]

10

[]

0

null

[ "Eukaryota" ]

[ 3649 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 4, 2, 2, 1, 18, 9, 4, 5, 1, 1, 15 ]

11

true

Domain

Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2

Gln-tRNA-synth_Ib_RNA-bd_2

6

IPR007639

7,639

Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal

Gln-tRNA-synth_Ib_RNA-bd_N

Domain

3,695

false

Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through a highly specific two-step reaction [ , ]. These enzymes vary widely in size and oligomeric state, and share limited sequence homology [ ]. The 20 aminoacyl-tRNA synth...

[ "GO:0000166", "GO:0004812", "GO:0005524", "GO:0006418", "GO:0005737" ]

[ "nucleotide binding", "aminoacyl-tRNA ligase activity", "ATP binding", "tRNA aminoacylation for protein translation", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF04558" ]

[ "tRNA_synt_1c_R1" ]

[ 3695 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.1.1.18", "R-BTA-9856649", "R-DDI-9856649", "R-DME-9856649", "R-HSA-2408522", "R-HSA-379716", "R-HSA-379726", "R-HSA-9856649", "R-MMU-9856649", "R-RNO-9856649" ]

[ "EC:6.1.1.18", "REACTOME:R-BTA-9856649", "REACTOME:R-DDI-9856649", "REACTOME:R-DME-9856649", "REACTOME:R-HSA-2408522", "REACTOME:R-HSA-379716", "REACTOME:R-HSA-379726", "REACTOME:R-HSA-9856649", "REACTOME:R-MMU-9856649", "REACTOME:R-RNO-9856649" ]

10

[ "3tl4", "4h3s", "4r3z", "4ye6", "4ye8", "4ye9", "8uk6" ]

7

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00010051", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10347214", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 1999, 2000, 2002 ]

10

[]

0

null

[ "Eukaryota" ]

[ 3695 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 4, 1, 2, 1, 18, 9, 5, 4, 1, 1, 13 ]

11

true

Domain

Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal

Gln-tRNA-synth_Ib_RNA-bd_N

2

IPR007640

7,640

Herpesvirus capsid vertex component 1

UL17-like

Family

616

false

This entry represents a group of capsid vertex components from Herpesvirus, including UL17 from Human herpesvirus 1. UL17 is a capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes [ ]...

[ "GO:0051276", "GO:0044423" ]

[ "chromosome organization", "virion component" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_04017", "PF04559" ]

[ "HSV_CVC1", "Herpes_UL17" ]

[ 485, 616 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "5zz8", "6cgr", "6m6g", "6m6h", "6odm", "6ppb", "6pph", "6w2d", "6w2e", "7bqx", "7br7", "7et3", "7etj", "7eto", "7fj1", "8hex", "8hey", "8tep", "8tes", "8tet", "8teu", "8tew", "8x9w", "8xa0", "9no1" ]

25

[ "PUB00076447" ]

[ "21632758" ]

[ "The herpes simplex virus 1 UL17 protein is the second constituent of the capsid vertex-specific component required for DNA packaging and retention." ]

[ 2011 ]

1

[]

0

null

[ "Actinomyces oris", "Herpesvirales", "Homo sapiens" ]

[ 2, 613, 1 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus capsid vertex component 1

UL17-like

9

IPR007641

7,641

RNA polymerase Rpb2, domain 7

RNA_pol_Rpb2_7

Domain

60,931

false

RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and cl...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF04560" ]

[ "RNA_pol_Rpb2_7" ]

[ 60931 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.6", "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953",...

[ "EC:2.7.7.6", "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086",...

214

[ "1hqm", "1i3q", "1i50", "1i6h", "1i6v", "1iw7", "1k83", "1l9u", "1l9z", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1smy", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "1ynj", "1ynn", "1zyr", "2a68", "2a69"...

1,214

[ "PUB00008731" ]

[ "11313498" ]

[ "Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1162, 26539, 31868, 432, 930 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 23, 3, 4, 4, 1, 17, 5, 3, 25, 8, 3, 3, 65 ]

13

true

Domain

RNA polymerase Rpb2, domain 7

RNA_pol_Rpb2_7

7

IPR007643

7,643

Dictyostelium spore coat protein, N-terminal

Dict_spore_N

Domain

78

false

The Dictyostelium discoideum (Slime mold) spore coat is a polarised extracellular matrix composed of glycoproteins and cellulose. Four of the major coat glycoproteins exist as a multi-protein complex within the prespore vesicles before secretion. Of these, SP96 and SP70 are members of this family. The presence of SP96 ...

[]

0

[ "PFAM" ]

[ "PF04562" ]

[ "Dicty_spore_N" ]

[ 78 ]

1

[]

0

[]

0

[ "PUB00010055" ]

[ "10931888" ]

[ "The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum." ]

[ 2000 ]

1

[]

0

null

[ "Dictyostelia" ]

[ 78 ]

1

[]

0

true

Domain

Dictyostelium spore coat protein, N-terminal

Dict_spore_N

7

IPR007644

7,644

RNA polymerase, beta subunit, protrusion

RNA_pol_bsu_protrusion

Domain

53,194

false

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion d...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF04563" ]

[ "RNA_pol_Rpb2_1" ]

[ 53194 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.6", "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953",...

[ "EC:2.7.7.6", "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086",...

214

[ "1hqm", "1i3q", "1i50", "1i6h", "1i6v", "1iw7", "1k83", "1l9u", "1l9z", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1smy", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "1ynj", "1ynn", "1zyr", "2a68", "2a69"...

1,195

[ "PUB00003220" ]

[ "3116266" ]

[ "RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase." ]

[ 1987 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 938, 27514, 23589, 247, 906 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 22, 3, 4, 4, 1, 14, 6, 3, 18, 9, 3, 3, 73 ]

13

true

Domain

RNA polymerase, beta subunit, protrusion

RNA_pol_bsu_protrusion

2

IPR007647

7,647

RNA polymerase Rpb2, domain 5

RNA_pol_Rpb2_5

Domain

42,872

false

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). Domain 5 is also known as the external 2 domain [ ].

[ "GO:0006351" ]

[ "DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04567" ]

[ "RNA_pol_Rpb2_5" ]

[ 42872 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.6", "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953",...

[ "EC:2.7.7.6", "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086",...

189

[ "1i3q", "1i50", "1i6h", "1k83", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "2b63", "2b8k", "2e2h", "2e2i", "2e2j", "2ja5", "2ja6", "2ja7", "2ja8", "2nvq", "2nvt"...

487

[ "PUB00008731" ]

[ "11313498" ]

[ "Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Eukaryota", "SAR86 cluster bacterium SAR86B", "Viruses", "unclassified sequences" ]

[ 1095, 41289, 1, 255, 232 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 3, 10, 2, 2, 14, 5, 2, 2, 71 ]

12

true

Domain

RNA polymerase Rpb2, domain 5

RNA_pol_Rpb2_5

2

IPR007648

7,648

Mitochondrial ATPase inhibitor

ATPase_inhibitor_mt

Family

3,942

false

ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [ ] ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the α-β interface. It is thought to inhibit ATP synthesis by...

[ "GO:0042030", "GO:0032780", "GO:0005739" ]

[ "ATPase inhibitor activity", "negative regulation of ATP-dependent activity", "mitochondrion" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04568" ]

[ "IATP" ]

[ 3942 ]

1

[]

0

[ "1gmj", "1ohh", "2v7q", "3zia", "4tsf", "4tt3", "4z1m", "5lqx", "5lqy", "5lqz", "6j5i", "6j5j", "6j5k", "6yw5", "6ywe", "6ywx", "6ywy", "6yy0", "6z1r", "6z1u", "6zpo", "6zqm", "6zqn", "7ajb", "7ajc", "7ajd", "7aje", "7ajf", "7ajg", "7ajh", "7aji", "7ajj"...

42

[ "PUB00010058", "PUB00019733" ]

[ "8961923", "12186878" ]

[ "The ATPase inhibitor protein from bovine heart mitochondria: the minimal inhibitory sequence.", "Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases." ]

[ 1996, 2002 ]

2

[]

0

null

[ "Eukaryota", "Nocardioides humilatus" ]

[ 3941, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 5, 2, 2, 5, 2, 3, 1, 4, 2, 1, 5 ]

11

true

Family

Mitochondrial ATPase inhibitor

ATPase_inhibitor_mt

2

IPR007650

7,650

Zf-FLZ domain

Zf-FLZ_dom

Domain

9,965

false

Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. The FCS-type zinc finger is a highly diverged group of C2-C2 zinc finger, named after the conserved phenylalanine and serine residues associated with the third cysteine. The FCS-type zinc finger is a structurall...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04570", "PS51795" ]

[ "zf-FLZ", "ZF_FLZ" ]

[ 9928, 9748 ]

2

[]

0

[]

0

[ "PUB00070912", "PUB00084258", "PUB00084259", "PUB00084260" ]

[ "24901469", "15159630", "26252898", "26442059" ]

[ "DUF581 Is Plant Specific FCS-Like Zinc Finger Involved in Protein-Protein Interaction.", "A novel zinc-finger protein with a proline-rich domain mediates ABA-regulated seed dormancy in Arabidopsis.", "Comprehensive Evolutionary and Expression Analysis of FCS-Like Zinc finger Gene Family Yields Insights into Th...

[ 2014, 2004, 2015, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Pyramimonas orientalis virus", "viral metagenome" ]

[ 8, 9952, 1, 4 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 66, 82, 137 ]

3

true

Domain

Zf-FLZ domain

Zf-FLZ_dom

8

IPR007651

7,651

Lipin, N-terminal

Lipin_N

Domain

10,556

false

Mutations in the lipin gene lead to fatty liver dystrophy in mice. The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. This entry represents a conserved domain found at the N terminus of the member proteins [ , ].

[]

0

[ "PFAM" ]

[ "PF04571" ]

[ "Lipin_N" ]

[ 10556 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.1.3.4", "PWY-6453", "PWY-7782", "PWY-8051", "PWY-8052", "PWY-8053", "PWY-8055", "R-HSA-1483191", "R-HSA-1483213", "R-HSA-4419969", "R-HSA-75109", "R-HSA-9841922", "R-MMU-1483191", "R-MMU-1483213", "R-MMU-4419969", "R-MMU-75109", "R-SCE-1483191", "R-SCE-1483213", "R-SCE-4419969...

[ "EC:3.1.3.4", "METACYC:PWY-6453", "METACYC:PWY-7782", "METACYC:PWY-8051", "METACYC:PWY-8052", "METACYC:PWY-8053", "METACYC:PWY-8055", "REACTOME:R-HSA-1483191", "REACTOME:R-HSA-1483213", "REACTOME:R-HSA-4419969", "REACTOME:R-HSA-75109", "REACTOME:R-HSA-9841922", "REACTOME:R-MMU-1483191", "R...

24

[]

0

[ "PUB00010059", "PUB00010121" ]

[ "11138012", "11792863" ]

[ "Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.", "Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 10556 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 12, 8, 9, 19, 1, 5, 14, 1, 1, 24 ]

12

true

Domain

Lipin, N-terminal

Lipin_N

6

IPR007652

7,652

Alpha 1,4-glycosyltransferase domain

A1-4-GlycosylTfrase_dom

Domain

5,279

false

The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vert...

[]

0

[ "PFAM" ]

[ "PF04572" ]

[ "Gb3_synth" ]

[ 5279 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1", "GenProp1304", "R-DME-913709", "R-DME-9840309", "R-HSA-913709", "R-HSA-9840309", "R-MMU-913709", "R-MMU-9840309", "R-RNO-9840309" ]

[ "EC:2.4.1", "GP:GenProp1304", "REACTOME:R-DME-913709", "REACTOME:R-DME-9840309", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-9840309", "REACTOME:R-MMU-913709", "REACTOME:R-MMU-9840309", "REACTOME:R-RNO-9840309" ]

9

[]

0

[ "PUB00010060" ]

[ "10854428" ]

[ "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Megamimivirinae", "metagenomes" ]

[ 177, 5097, 3, 2 ]

4

[ "Arabidopsis thaliana", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 25, 3, 22, 5, 7, 4, 5 ]

7

true

Domain

Alpha 1,4-glycosyltransferase domain

A1-4-GlycosylTfrase_dom

9

IPR007653

7,653

Signal peptidase complex subunit 3

SPC3

Family

4,814

false

This entry includes signal peptidase complex subunit 3 (Spc3, also known as SPC22) and its homologues from fungi, plants and animals. Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal...

[ "GO:0006465", "GO:0005787", "GO:0016020" ]

[ "signal peptide processing", "signal peptidase complex", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF04573", "PIRSF016089", "PTHR12804" ]

[ "SPC22", "SPC22", "" ]

[ 4810, 4041, 4618 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2038", "R-BTA-422085", "R-BTA-9768727", "R-CFA-422085", "R-CFA-9768727", "R-DME-9768727", "R-GGA-422085", "R-GGA-9768727", "R-HSA-1799339", "R-HSA-381771", "R-HSA-400511", "R-HSA-422085", "R-HSA-9768727", "R-HSA-9828806", "R-MMU-422085", "R-MMU-9768727" ]

[ "GP:GenProp2038", "REACTOME:R-BTA-422085", "REACTOME:R-BTA-9768727", "REACTOME:R-CFA-422085", "REACTOME:R-CFA-9768727", "REACTOME:R-DME-9768727", "REACTOME:R-GGA-422085", "REACTOME:R-GGA-9768727", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-381771", "REACTOME:R-HSA-400511", "REACTOME:R-HSA-42208...

16

[ "7p2p", "7p2q" ]

2

[ "PUB00010061", "PUB00010062" ]

[ "8632014", "9148931" ]

[ "Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex.", "The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity." ]

[ 1996, 1997 ]

2

[]

0

null

[ "Eukaryota", "Shewanella electrica" ]

[ 4813, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 1, 3, 1, 7, 6, 1, 1, 16 ]

12

true

Family

Signal peptidase complex subunit 3

SPC3

1

IPR007654

7,654

NAD-dependent histone deacetylase Sir2, N-terminal

NAD-dep_histone_deAcase_SIR2_N

Domain

402

false

This N-terminal region is found in SIR2 proteins ( ) and its homologues. Its function is uncharacterised.

[]

0

[ "PFAM" ]

[ "PF04574" ]

[ "DUF592" ]

[ 402 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "2.3.1.286", "R-SCE-427359", "R-SPO-427359" ]

[ "EC:2.3.1.286", "REACTOME:R-SCE-427359", "REACTOME:R-SPO-427359" ]

3

[ "2hjh", "4iao" ]

2

[]

0

[]

0

null

[ "Fungi" ]

[ 402 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

NAD-dependent histone deacetylase Sir2, N-terminal

NAD-dep_histone_deAcase_SIR2_N

1

IPR007655

7,655

Surface lipoprotein assembly modifier, C-terminal domain

Slam_C

Domain

2,426

false

Slam, also known as NTHI1171 in Haemophilus influenzae, is a surface lipoprotein that may have a role in virulence [ ]. In Neisseria, it is required for the surface display of lipidated virulence factors [ ]. This entry represents the C-terminal eight-stranded β-barrel domain [ ].

[]

0

[ "PFAM" ]

[ "PF04575" ]

[ "SlipAM" ]

[ 2426 ]

1

[]

0

[]

0

[ "PUB00095100", "PUB00095101" ]

[ "28620585", "27572441" ]

[ "Identification of a Large Family of Slam-Dependent Surface Lipoproteins in Gram-Negative Bacteria.", "Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria." ]

[ 2017, 2016 ]

2

[]

0

null

[ "Bacteria", "Knufia peltigerae", "metagenomes" ]

[ 2401, 1, 24 ]

3

[]

0

true

Domain

Surface lipoprotein assembly modifier, C-terminal domain

Slam_C

7

IPR007656

7,656

GTD-binding domain

GTD-bd

Domain

7,628

false

The GTD-binding domain is a plant-specific protein-protein interaction domain. It emerged in primitive land plants and founded a multigene family that is conserved in all flowering plants. Proteins with GTD-binding domains fall into four groups, where group 1-3 contain the GTD-binding domain at the C-terminal half of t...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04576", "PS51775" ]

[ "Zein-binding", "GTD_BINDING" ]

[ 7565, 7544 ]

2

[]

0

[]

0

[ "PUB00057496", "PUB00072955", "PUB00084274", "PUB00084275" ]

[ "17693529", "23995081", "25387880", "24944111" ]

[ "The maize floury1 gene encodes a novel endoplasmic reticulum protein involved in zein protein body formation.", "Identification of myosin XI receptors in Arabidopsis defines a distinct class of transport vesicles.", "RISAP is a TGN-associated RAC5 effector regulating membrane traffic during polar cell growth i...

[ 2007, 2013, 2014, 2014 ]

4

[]

0

null

[ "Pseudomonas", "Streptophyta" ]

[ 2, 7626 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 80, 40, 88 ]

3

true

Domain

GTD-binding domain

GTD-bd

7

IPR007657

7,657

Glycosyltransferase 61

Glycosyltransferase_61

Family

19,356

false

Glycosyltransferase 61 family members are further processed into a mature form. Proteins in this family includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as EOGTL) [ ] and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) [ ]. This entry also includes plant beta...

[ "GO:0016757" ]

[ "glycosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PANTHER", "PANTHER" ]

[ "PTHR20961", "PTHR48437" ]

[ "", "" ]

[ 18611, 745 ]

2

[ "EC", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1", "GenProp1444", "GenProp1455", "R-BTA-8932505", "R-CFA-8932505", "R-DRE-8932505", "R-GGA-8932505", "R-HSA-8932505", "R-MMU-8932505", "R-RNO-8932505", "R-XTR-8932505" ]

[ "EC:2.4.1", "GP:GenProp1444", "GP:GenProp1455", "REACTOME:R-BTA-8932505", "REACTOME:R-CFA-8932505", "REACTOME:R-DRE-8932505", "REACTOME:R-GGA-8932505", "REACTOME:R-HSA-8932505", "REACTOME:R-MMU-8932505", "REACTOME:R-RNO-8932505", "REACTOME:R-XTR-8932505" ]

11

[ "6xfi", "6xi2", "7e9j", "7e9k", "7e9l", "8kb7" ]

6

[ "PUB00083303", "PUB00083304", "PUB00083305" ]

[ "23929950", "23671640", "10781814" ]

[ "SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.", "The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila.", "Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from A...

[ 2013, 2013, 2000 ]

3

[]

[ "IPR024698" ]

0

1

0

[ "Bacteria", "Eukaryota", "Florenciella sp. virus SA2", "Methanobacteriota", "metagenomes" ]

[ 1622, 17637, 1, 66, 30 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 59, 1, 5, 2, 4, 2, 79, 7, 149 ]

9

true

Family

Glycosyltransferase 61

Glycosyltransferase_61

9

IPR007658

7,658

Protein of unknown function DUF594

DUF594

Family

10,277

false

This is a family of uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF04578" ]

[ "DUF594" ]

[ 10277 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 10277 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 40, 319, 124 ]

3

true

Family

Protein of unknown function DUF594

DUF594

5

IPR007659

7,659

Keratin, high-sulphur matrix protein

Keratin_matx

Family

1,245

false

This is a family of keratins, high-sulphur matrix proteins. The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulphur and high-tyrosine keratins, having molecular weights of 6-20kDa, wh...

[ "GO:0005198", "GO:0045095" ]

[ "structural molecule activity", "keratin filament" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04579", "PTHR23260" ]

[ "Keratin_matx", "" ]

[ 394, 1224 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6805567", "R-HSA-6805567", "R-MMU-6805567" ]

[ "REACTOME:R-BTA-6805567", "REACTOME:R-HSA-6805567", "REACTOME:R-MMU-6805567" ]

3

[]

0

[ "PUB00010063" ]

[ "4678578" ]

[ "The amino acid sequence of protein SCMK-B2C from the high-sulphur fraction of wool keratin." ]

[ 1972 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1245 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 10, 10 ]

3

true

Family

Keratin, high-sulphur matrix protein

Keratin_matx

3

IPR007660

7,660

Poxvirus D3

Poxvirus_D3

Family

155

false

This entry represents Protein D3 from Vaccinia virus, also known as Core protein OPG115, and similar sequences from poxvirus. D3 is a late protein which is part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal contents...

[]

0

[ "PFAM" ]

[ "PF04580" ]

[ "Pox_D3" ]

[ 155 ]

1

[]

0

[]

0

[ "PUB00078900" ]

[ "15567438" ]

[ "A complex of seven vaccinia virus proteins conserved in all chordopoxviruses is required for the association of membranes and viroplasm to form immature virions." ]

[ 2004 ]

1

[]

0

null

[ "Poxviridae" ]

[ 155 ]

1

[]

0

true

Family

Poxvirus D3

Poxvirus_D3

1

IPR007662

7,662

Reovirus sigma C capsid protein, C-terminal

SigmaC_C

Domain

867

false

Protein sigmaC in its native state was shown to be a homotrimer. It was demonstrated that the sigmaC subunits are not covalently bound via disulphide linkages and the formation of an intrachain disulphide bond between the two cysteine residues of the sigmaC polypeptide may have a negative effect on oligomer stability. ...

[]

0

[ "PFAM" ]

[ "PF04582" ]

[ "Reo_sigmaC" ]

[ 867 ]

1

[]

0

[ "2bsf", "2bt7", "2bt8", "2jjl", "2vrs" ]

5

[ "PUB00010107" ]

[ "11752709" ]

[ "Subunit composition and conformational stability of the oligomeric form of the avian reovirus cell-attachment protein sigmaC." ]

[ 2002 ]

1

[]

0

null

[ "Orthoreovirus" ]

[ 867 ]

1

[]

0

true

Domain

Reovirus sigma C capsid protein, C-terminal

SigmaC_C

6

IPR007663

7,663

Baculoviridae p74

Baculo_p74

Family

270

false

Baculoviruses are distinct from other virus families in that there are two viral phenotypes: budded virus (BV) and occlusion-derived virus (ODV). BVs disseminate viral infection throughout the tissues of the host and ODVs transmit baculovirus between insect hosts. In the Autographa californica nuclear polyhedrosis viru...

[ "GO:0019058" ]

[ "viral life cycle" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04583" ]

[ "Baculo_p74" ]

[ 270 ]

1

[]

0

[]

0

[ "PUB00082602", "PUB00082603", "PUB00082604" ]

[ "15744572", "15194753", "20007360" ]

[ "The function of envelope protein P74 from Autographa californica multiple nucleopolyhedrovirus in primary infection to host.", "P74 mediates specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to primary cellular targets in the midgut epithelia of Heliothis virescens Larvae....

[ 2005, 2004, 2010 ]

3

[]

0

null

[ "Protostomia", "Viruses", "viral metagenome" ]

[ 37, 232, 1 ]

3

[]

0

true

Family

Baculoviridae p74

Baculo_p74

4

IPR007664

7,664

Poxvirus A28

Poxvirus_A28

Family

137

false

The poxvirus A28 protein, also known as Envelope protein OPG155, is expressed at late times during the virus replication cycle and is a membrane component of the intracellular mature virion. Repression of A28 inhibits cell-to-cell spread, suggesting that all poxviruses use a common A28-dependent mechanism of cell penet...

[ "GO:0016032", "GO:0019031" ]

[ "viral process", "viral envelope" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04584" ]

[ "Pox_A28" ]

[ 137 ]

1

[]

0

[ "8gqo" ]

1

[ "PUB00014940", "PUB00014941" ]

[ "14963132", "14963131" ]

[ "Vaccinia virus entry into cells is dependent on a virion surface protein encoded by the A28L gene.", "Vaccinia virus A28L gene encodes an essential protein component of the virion membrane with intramolecular disulfide bonds formed by the viral cytoplasmic redox pathway." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Poxviridae" ]

[ 137 ]

1

[]

0

true

Family

Poxvirus A28

Poxvirus_A28

2

IPR007666

7,666

ADP-specific phosphofructokinase/glucokinase

ADP_PFK/GK

Family

3,046

false

Although ATP is the most common phosphoryl group donor for kinases, certain hyperthermophilic archaea, such as Thermococcus litoralis and Pyrococcus furiosus, utilise unusual ADP-dependent glucokinases (ADPGKs) and phosphofructokinases (ADPPKKs) in their glycolytic pathways [ , , ]. ADPGKs and ADPPFKs exhibit significa...

[ "GO:0016773", "GO:0005975" ]

[ "phosphotransferase activity, alcohol group as acceptor", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE", "PANTHER" ]

[ "PF04587", "PS51255", "PTHR21208" ]

[ "ADP_PFK_GK", "ADPK", "" ]

[ 2889, 2843, 2852 ]

3

[ "EC", "EC", "GP", "METACYC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "2.7.1.147", "GenProp1522", "PWY-6855", "PDOC51255", "R-BTA-70171", "R-CEL-70171", "R-HSA-70171", "R-MMU-70171" ]

[ "EC:2.7.1", "EC:2.7.1.147", "GP:GenProp1522", "METACYC:PWY-6855", "PROSITEDOC:PDOC51255", "REACTOME:R-BTA-70171", "REACTOME:R-CEL-70171", "REACTOME:R-HSA-70171", "REACTOME:R-MMU-70171" ]

9

[ "1gc5", "1l2l", "1u2x", "1ua4", "3drw", "4b8r", "4b8s", "5ccf", "5ck7", "5k27", "5kkg", "5o0i", "5o0j", "5o5x", "5o5y", "5o5z", "5od2", "6c8z", "6xio" ]

19

[ "PUB00013528", "PUB00015867", "PUB00025218", "PUB00026897", "PUB00031716", "PUB00099921" ]

[ "11778837", "11717273", "11286887", "12237466", "12909015", "26555263" ]

[ "The biochemical properties and phylogenies of phosphofructokinases from extremophiles.", "ADP-dependent phosphofructokinases in mesophilic and thermophilic methanogenic archaea.", "Structural basis for the ADP-specificity of a novel glucokinase from a hyperthermophilic archaeon.", "Crystal structure of the A...

[ 2001, 2001, 2001, 2002, 2003, 2016 ]

6

[]

[ "IPR015990" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 312, 343, 2381, 10 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 2, 6, 5, 5 ]

6

true

Family

ADP-specific phosphofructokinase/glucokinase

ADP_PFK/GK

9

IPR007668

7,668

RFX1 transcription activation region

RFX1_trans_act

Domain

4,364

false

The RFX family is a family of winged-helix DNA-binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is found N-terminal to the RFX DNA-binding region ( ) in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analy...

[ "GO:0003677", "GO:0006355", "GO:0005634" ]

[ "DNA binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04589" ]

[ "RFX1_trans_act" ]

[ 4364 ]

1

[]

0

[]

0

[ "PUB00010068" ]

[ "9278482" ]

[ "The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities." ]

[ 1997 ]

1

[]

0

null

[ "Bilateria" ]

[ 4364 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 16, 11, 15 ]

4

true

Domain

RFX1 transcription activation region

RFX1_trans_act

3

IPR007669

7,669

Carbohydrate sulfotransferase Chst-1-like

Chst-1-like

Family

1,172

false

A chondroitin sulfate (CS) sulfotransferase has been identified in the nematode Caenorhabditis elegans, and has been named as chst-1 (CarboHydrate SulfoTransferase) [ ]. This chondroitin 4-O-sulfotransferase plays an important role in protecting nematodes from oxidative stress [ ].

[ "GO:0047756", "GO:0050650", "GO:1902884" ]

[ "chondroitin 4-sulfotransferase activity", "chondroitin sulfate proteoglycan biosynthetic process", "positive regulation of response to oxidative stress" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PANTHER" ]

[ "PTHR22900" ]

[ "" ]

[ 1172 ]

1

[]

0

[]

0

[ "PUB00085650", "PUB00085656" ]

[ "27645998", "27703236" ]

[ "Chondroitin 4-O-Sulfotransferase Is Indispensable for Sulfation of Chondroitin and Plays an Important Role in Maintaining Normal Life Span and Oxidative Stress Responses in Nematodes.", "Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransfer...

[ 2016, 2016 ]

2

[ "IPR005331" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1172 ]

1

[ "Caenorhabditis elegans" ]

[ 31 ]

1

true

Family

Carbohydrate sulfotransferase Chst-1-like

Chst-1-like

4

IPR007670

7,670

Protein of unknown function DUF596

DUF596

Family

391

false

This family contains several uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF04591" ]

[ "DUF596" ]

[ 391 ]

1

[]

0

[ "2o5h" ]

1

[]

0

[]

0

null

[ "Bacteria", "Diploscapter pachys" ]

[ 390, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF596

DUF596

6

IPR007671

7,671

Selenoprotein P, N-terminal

Selenoprotein-P_N

Domain

1,814

false

SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [ ]. It is thought to be glycosylated [ ]. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascula...

[]

0

[ "PFAM" ]

[ "PF04592" ]

[ "SelP_N" ]

[ 1814 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114608", "R-DRE-114608", "R-HSA-114608", "R-MMU-114608", "R-RNO-114608" ]

[ "REACTOME:R-BTA-114608", "REACTOME:R-DRE-114608", "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608", "REACTOME:R-RNO-114608" ]

5

[]

0

[ "PUB00010069", "PUB00010070", "PUB00010071", "PUB00099818" ]

[ "10775431", "11168591", "9358058", "17311913" ]

[ "Selenoprotein P: properties, functions, and regulation.", "Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.", "Analysis of bovine selenoprotein P-like protein gene and availability of metal responsive element (MRE) located ...

[ 2000, 2000, 1997, 2007 ]

4

[]

0

null

[ "Eukaryota", "Pseudomonadati", "marine metagenome" ]

[ 1804, 8, 2 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 4, 2 ]

4

true

Domain

Selenoprotein P, N-terminal

Selenoprotein-P_N

8

IPR007672

7,672

Selenoprotein P, C-terminal

SelP_C

Domain

105

false

SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [ ]. It is thought to be glycosylated [ ]. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascula...

[]

0

[ "PFAM" ]

[ "PF04593" ]

[ "SelP_C" ]

[ 105 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114608", "R-DRE-114608", "R-HSA-114608", "R-MMU-114608", "R-RNO-114608" ]

[ "REACTOME:R-BTA-114608", "REACTOME:R-DRE-114608", "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608", "REACTOME:R-RNO-114608" ]

5

[]

0

[ "PUB00010069", "PUB00010070", "PUB00010071" ]

[ "10775431", "11168591", "9358058" ]

[ "Selenoprotein P: properties, functions, and regulation.", "Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.", "Analysis of bovine selenoprotein P-like protein gene and availability of metal responsive element (MRE) located ...

[ 2000, 2000, 1997 ]

3

[]

0

null

[ "Euteleostomi" ]

[ 105 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 1 ]

4

true

Domain

Selenoprotein P, C-terminal

SelP_C

7

IPR007673

7,673

Condensin subunit 1

Condensin_cplx_su1

Family

3,827

false

This entry includes condensin subunit 1 (CND1). CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like ...

[ "GO:0000278", "GO:0030261", "GO:0005634" ]

[ "mitotic cell cycle", "chromosome condensation", "nucleus" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF017127" ]

[ "Condensin_D2" ]

[ 3827 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2514853", "R-MMU-2514853", "R-SCE-2514853", "R-SPO-2514853" ]

[ "REACTOME:R-HSA-2514853", "REACTOME:R-MMU-2514853", "REACTOME:R-SCE-2514853", "REACTOME:R-SPO-2514853" ]

4

[ "6qj3", "6qj4", "6yvu", "6yvv", "7q2x", "7q2y", "7qen" ]

7

[ "PUB00007177", "PUB00010072", "PUB00056005", "PUB00062096", "PUB00062097", "PUB00100765" ]

[ "12138188", "9774278", "20442714", "11854418", "11136719", "27737959" ]

[ "Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.", "Phosphorylation and activation of 13S condensin by Cdc2 in vitro.", "Condensin and cohesin complexity: the expanding repertoire of functions.", "Mutation of YCS4, a budding yeast condensin subunit, affects mi...

[ 2002, 1998, 2010, 2002, 2001, 2016 ]

6

[ "IPR026971" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3827 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 1, 1, 6, 2, 1, 3, 4, 1, 1, 11 ]

12

true

Family

Condensin subunit 1

Condensin_cplx_su1

1

IPR007674

7,674

Poxvirus F5/Telomere-binding protein I6 domain

Poxvirus_F5/I6_dom

Domain

234

false

This entry represents a domain found in 36 kDa major membrane protein F5 and Telomere-binding protein I6 from Vaccinia virus, and similar sequences from poxvirus. F5, also named Protein OPG049, plays a role in the spread of virus to neighbouring cells ex vivo [ ]. I6, also known as Telomere-binding protein OPG082, bind...

[ "GO:0016032" ]

[ "viral process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04595" ]

[ "Pox_I6" ]

[ 234 ]

1

[]

0

[]

0

[ "PUB00010106", "PUB00103698", "PUB00103699" ]

[ "11581377", "14512543", "24889234" ]

[ "Vaccinia virus telomeres: interaction with the viral I1, I6, and K4 proteins.", "Genetic analysis of the vaccinia virus I6 telomere-binding protein uncovers a key role in genome encapsidation.", "Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or...

[ 2001, 2003, 2014 ]

3

[]

0

null

[ "Poxviridae" ]

[ 234 ]

1

[]

0

true

Domain

Poxvirus F5/Telomere-binding protein I6 domain

Poxvirus_F5/I6_dom

2

IPR007675

7,675

Poxvirus F15

Poxvirus_F15

Family

103

false

This entry represents Protein F15 from Vaccinia virus, also known as Protein OPG060, and similar sequences from poxvirus. The function of this protein is still unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04596", "PIRSF015694" ]

[ "Pox_F15", "VAC_F15L" ]

[ 103, 94 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Poxviridae" ]

[ 103 ]

1

[]

0

true

Family

Poxvirus F15

Poxvirus_F15

6

IPR007676

7,676

Ribophorin I

Ribophorin_I

Family

6,254

false

Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase, ( ). OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocat...

[ "GO:0009101", "GO:0016020" ]

[ "glycoprotein biosynthetic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04597", "PTHR21049" ]

[ "Ribophorin_I", "" ]

[ 6193, 6157 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-9768727", "R-HSA-1799339", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-9768727" ]

[ "REACTOME:R-CFA-9768727", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-446203", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-9768727", "REACTOME:R-MMU-9768727", "REACTOME:R-RNO-9768727" ]

7

[ "6c26", "6ezn", "6ftj", "6s7o", "6s7t", "7oci", "8agb", "8agc", "8age", "8b6l", "8pn9" ]

11

[ "PUB00010074", "PUB00010075", "PUB00093744" ]

[ "7720878", "11443278", "31810196" ]

[ "The essential yeast NLT1 gene encodes the 64 kDa glycoprotein subunit of the oligosaccharyl transferase.", "The oligosaccharyltransferase complex from pig liver: cDNA cloning, expression and functional characterisation.", "Oligosaccharyltransferase: A Gatekeeper of Health and Tumor Progression." ]

[ 1995, 2000, 2019 ]

3

[]

0

null

[ "Archaea", "Eukaryota", "marine sediment metagenome" ]

[ 7, 6241, 6 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 4, 8, 5, 1, 6, 5, 1, 1, 17 ]

12

true

Family

Ribophorin I

Ribophorin_I

8

IPR007677

7,677

Gasdermin

Family

1,574

false

The precise function of this protein is unknown. However, it is thought that this entry represents the gasdermin family which plays a role as a secretory or metabolic product involved in the secretory pathway and includes gasdermins A-E (GSDMA-E). A N-terminal fragment released by proteolysis of gasmerdin A binds to li...

[]

0

[ "PANTHER" ]

[ "PTHR16399" ]

[ "" ]

[ 1574 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-111457", "R-HSA-448706", "R-HSA-5620971", "R-HSA-5686938", "R-HSA-6798695", "R-HSA-9660826", "R-MMU-111457", "R-MMU-448706", "R-MMU-5620971", "R-MMU-5686938", "R-MMU-6798695" ]

[ "REACTOME:R-HSA-111457", "REACTOME:R-HSA-448706", "REACTOME:R-HSA-5620971", "REACTOME:R-HSA-5686938", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9660826", "REACTOME:R-MMU-111457", "REACTOME:R-MMU-448706", "REACTOME:R-MMU-5620971", "REACTOME:R-MMU-5686938", "REACTOME:R-MMU-6798695" ]

11

[ "5b5r", "5nh1", "5wqt", "6ao3", "6ao4", "6cb8", "6kmv", "6kmz", "6kn0", "6n9n", "6n9o", "6vfe", "6vie", "7wjq", "7z1x", "8efp", "8et1", "8et2", "8gbe", "8gtj", "8gtk", "8gtn", "9hjp" ]

23

[ "PUB00010076", "PUB00053860", "PUB00053861", "PUB00088058", "PUB00088060", "PUB00091059" ]

[ "9771715", "15010812", "18038310", "27281216", "28459430", "29990470" ]

[ "Nonsyndromic hearing impairment is associated with a mutation in DFNA5.", "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon.", "Differential expression and localisation of gasdermin-like (GSDML), a novel...

[ 1998, 2004, 2008, 2016, 2017, 2018 ]

6

[]

0

null

[ "Bilateria", "Eptesipox virus" ]

[ 1573, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 17, 16 ]

3

true

Family

Gasdermin

4

IPR007678

7,678

Poxvirus G5

Poxvirus_G5

Family

186

false

This entry represents Protein G5 from Vaccinia virus, also known as Putative nuclease OPG089, and similar sequences from poxvirus. G5 seems to be required for double-strand break repair, homologous recombination, and production of full-length viral genomic DNA [ , ].

[]

0

[ "PFAM" ]

[ "PF04599" ]

[ "Pox_G5" ]

[ 186 ]

1

[]

0

[]

0

[ "PUB00103617", "PUB00103618" ]

[ "19805122", "15367589" ]

[ "Predicted poxvirus FEN1-like nuclease required for homologous recombination, double-strand break repair and full-size genome formation.", "Vaccinia virus mutants with alanine substitutions in the conserved G5R gene fail to initiate morphogenesis at the nonpermissive temperature." ]

[ 2009, 2004 ]

2

[]

0

null

[ "Poxviridae" ]

[ 186 ]

1

[]

0

true

Family

Poxvirus G5

Poxvirus_G5

8

IPR007679

7,679

Beta-trefoil domain of unknown function DUF569

DUF569

Domain

3,310

false

This domain is found in a family of hypothetical proteins mainly from plants. Some family members contain two copies of the domain. It is predicted to adopt a β-trefoil fold.

[]

0

[ "PFAM" ]

[ "PF04601" ]

[ "DUF569" ]

[ 3310 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3310 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 35, 36, 64 ]

3

true

Domain

Beta-trefoil domain of unknown function DUF569

DUF569

9

IPR007680

7,680

Arabinofuranosyltransferase, central domain

Arabino_trans_central

Domain

3,262

false

Arabinosyltransferases EmbA, EmbB and EmbC are known to be involved in arabinogalactan (AG) and lipoarabinomannan (LAM) biosynthesis in mycobacteria. Synthesis of LAM, but not AG, ceases after inactivation of EmbC, while the arabinan of AG is affected by EmbA or EmbB disruption [ ]. The arabinans of the mycobacterial c...

[ "GO:0052636", "GO:0071766" ]

[ "arabinosyltransferase activity", "Actinobacterium-type cell wall biogenesis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04602" ]

[ "Arabinose_trans" ]

[ 3262 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.2.-", "PWY-5381", "PWY-5800", "PWY-6148", "PWY-6720", "PWY-7018", "PWY-7025", "PWY-7450", "PWY-7817", "PWY-7981" ]

[ "EC:2.4.2.-", "METACYC:PWY-5381", "METACYC:PWY-5800", "METACYC:PWY-6148", "METACYC:PWY-6720", "METACYC:PWY-7018", "METACYC:PWY-7025", "METACYC:PWY-7450", "METACYC:PWY-7817", "METACYC:PWY-7981" ]

10

[ "6x0o", "7bvc", "7bve", "7bvf", "7bvg", "7bvh", "7bwr", "7bx8" ]

8

[ "PUB00010078", "PUB00059156" ]

[ "8876238", "14507364" ]

[ "The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.", "The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition regio...

[ 1996, 2003 ]

2

[]

0

null

[ "Bacillati", "Cladonia borealis", "freshwater metagenome" ]

[ 3259, 1, 2 ]

3

[]

0

true

Domain

Arabinofuranosyltransferase, central domain

Arabino_trans_central

6

IPR007681

7,681

Ran-interacting Mog1 protein

Mog1

Family

4,229

false

Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. ...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF04603", "PTHR15837", "cd00224" ]

[ "Mog1", "", "Mog1" ]

[ 3492, 4114, 229 ]

3

[ "REACTOME" ]

[ "R-HSA-5576892" ]

[ "REACTOME:R-HSA-5576892" ]

1

[ "1eq6", "1jhs", "5yfg" ]

3

[ "PUB00015069" ]

[ "11733047" ]

[ "Identification of a conserved loop in Mog1 that releases GTP from Ran." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4229 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 4, 1, 1, 2, 2, 3, 3, 1, 1, 3 ]

10

true

Family

Ran-interacting Mog1 protein

Mog1

1

IPR007682

7,682

Lantibiotic, type A, Lactobacillales-type

Lantibiotic_typ-A_Lactobact

Family

213

false

Lantibiotics are heavily-modified bacteriocin-like peptides from Gram-positive bacteria. They contain alpha,beta-unsaturated amino acids (dehydroalanine and dehydrobutyrine) and lanthionine or 3-methyllanthionine rings (collectively known as thioether rings). There are 2 types of lantibiotic: Type A (which include nisi...

[ "GO:0042742", "GO:0005576" ]

[ "defense response to bacterium", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04604" ]

[ "L_biotic_typeA" ]

[ 213 ]

1

[]

0

[ "5z5q", "5z5r" ]

2

[]

0

[]

0

null

[ "Bacteria" ]

[ 213 ]

1

[]

0

true

Family

Lantibiotic, type A, Lactobacillales-type

Lantibiotic_typ-A_Lactobact

9

IPR007684

7,684

Zinc finger, Ogr/Delta-type

Znf_Ogr/Delta

Domain

4,513

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[]

0

[ "PFAM" ]

[ "PF04606" ]

[ "Ogr_Delta" ]

[ 4513 ]

1

[]

0

[]

0

[ "PUB00010081", "PUB00010082", "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "1597424", "9143285", "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Escherichia coli K-12 and B contain functional bacteriophage P2 ogr genes.", "The two P2 Ogr-like domains of the delta protein from bacteriophage P4 are required for activity.", "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA ...

[ 1992, 1997, 2002, 2007, 2005, 2005, 1999, 2001 ]

8

[]

0

null

[ "Bacteria", "Thelohanellus kitauei", "Viruses", "metagenomes" ]

[ 4378, 1, 121, 13 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Zinc finger, Ogr/Delta-type

Znf_Ogr/Delta

2

IPR007687

7,687

Methyl-coenzyme M reductase, protein C

Me_CoM_Rdtase_prot-C

Family

247

false

Members of this protein family are protein C, a non-structural protein, of the operon for methyl coenzyme M reductase [ ], also called coenzyme-B sulfoethylthiotransferase ( ). That enzyme, with alpha, beta, and gamma subunits, catalyzes the last step in methanogenesis; it has several modified sites, so accessory prote...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF003137", "TIGR03264" ]

[ "McrC", "met_CoM_red_C" ]

[ 240, 247 ]

2

[ "GP", "GP" ]

[ "GenProp0719", "GenProp0722" ]

[ "GP:GenProp0719", "GP:GenProp0722" ]

2

[ "8s7v", "8s7x", "9h1l" ]

3

[ "PUB00013556", "PUB00043078" ]

[ "8359675", "8177216" ]

[ "Identification of the mcrC gene product in Methanococcus vannielii.", "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus." ]

[ 1993, 1994 ]

2

[ "IPR026327" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 242, 5 ]

2

[]

0

true

Family

Methyl-coenzyme M reductase, protein C

Me_CoM_Rdtase_prot-C

2

IPR007688

7,688

Plasmid conjugal transfer TrbL/VirB6

Conjugal_tfr_TrbL/VirB6

Family

10,002

false

VirB proteins are suggested to act at the bacterial surface and there play an important role in directing t-DNA transfer to plant cells. VirB6 from Agrobacterium tumefaciens is an essential component of the type IV secretion machinery for T pilus formation and genetic transformation of plants. Absence of VirB6 leads to...

[ "GO:0030255" ]

[ "protein secretion by the type IV secretion system" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04610" ]

[ "TrbL" ]

[ 10002 ]

1

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[ "7o3v", "8rt9", "8rtb", "8rtd" ]

4

[ "PUB00019242", "PUB00020483" ]

[ "10438776", "9679196" ]

[ "Essential components of the Ti plasmid trb system, a type IV macromolecular transporter.", "Structural characterization of the virB operon on the hairy-root-inducing plasmid A4." ]

[ 1999, 1998 ]

2

[]

[ "IPR014150" ]

0

1

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 9884, 3, 53, 8, 54 ]

5

[]

0

true

Family

Plasmid conjugal transfer TrbL/VirB6

Conjugal_tfr_TrbL/VirB6

1

IPR007689

7,689

A-alpha-Y mating type-dependent binding domain

AalphaY_mating_typ-dep-bd-dom

Domain

7

false

Mating-type protein A-alpha specifies the A-alpha-Y mating type. The A-alpha-Y protein binds to the AalphaZ protein of another mating type in Schizophyllum commune [ ] and may also regulate gene expression of the homokaryotic cell.

[ "GO:0006355", "GO:0019953" ]

[ "regulation of DNA-templated transcription", "sexual reproduction" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF04611" ]

[ "AalphaY_MDB" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00010087" ]

[ "9286672" ]

[ "Schizophyllum commune A alpha mating-type proteins, Y and Z, form complexes in all combinations in vitro." ]

[ 1997 ]

1

[]

0

null

[ "Schizophyllum" ]

[ 7 ]

1

[]

0

true

Domain

A-alpha-Y mating type-dependent binding domain

AalphaY_mating_typ-dep-bd-dom

6

IPR007690

7,690

Type II secretion system protein GspM

T2SS_GspM

Family

5,362

false

GspM is part of the inner membrane component of the type II secretion system (T2SS). It consists of a short cytosolic N-terminal domain, a transmembrane domain, and a C-terminal periplasmic domain. The precise function of this protein is unknown [ ]. However, though in Vibrio cholerae, the EpsM protein interacts with t...

[ "GO:0015628", "GO:0015627" ]

[ "protein secretion by the type II secretion system", "type II protein secretion system complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF04612", "PIRSF006291" ]

[ "T2SSM", "GspM" ]

[ 5362, 1608 ]

2

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "1uv7", "7ze0", "8a9x", "8ab1" ]

4

[ "PUB00010089", "PUB00051842", "PUB00093998", "PUB00094002", "PUB00094004", "PUB00094009" ]

[ "10322014", "19217396", "30767847", "28258547", "22523076", "24223969" ]

[ "Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae.", "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Architecture, Function, and Substrates of the Type II Secretion System.", "1H, ...

[ 1999, 2009, 2019, 2017, 2012, 2013 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5253, 13, 96 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Type II secretion system protein GspM

T2SS_GspM

6

IPR007691

7,691

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD

LpxD

Family

17,166

false

This entry represents LpxD, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species. This protein represents the third step from UDP-N-acetyl-D-glucosamine [ ]. T...

[ "GO:0016410", "GO:0009245" ]

[ "N-acyltransferase activity", "lipid A biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00523", "PTHR43378", "TIGR01853", "cd03352" ]

[ "LpxD", "", "lipid_A_lpxD", "LbH_LpxD" ]

[ 13815, 17113, 14670, 16804 ]

4

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.191", "GenProp0204", "GenProp1290", "PWY-8073", "PWY-8245", "PWY-8283" ]

[ "EC:2.3.1.191", "GP:GenProp0204", "GP:GenProp1290", "METACYC:PWY-8073", "METACYC:PWY-8245", "METACYC:PWY-8283" ]

6

[ "2iu8", "2iu9", "2iua", "3eh0", "3pmo", "4e75", "4e79", "4ihf", "4ihg", "4ihh", "6p83", "6p84", "6p85", "6p86", "6p87", "6p88", "6p89", "6p8a", "6p8b", "6uec", "6ued" ]

21

[ "PUB00010088", "PUB00013504", "PUB00080090", "PUB00080096" ]

[ "8366125", "10753930", "21709257", "15498873" ]

[ "The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis.", "Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid a of the lipopolysaccharide from the...

[ 1993, 2000, 2011, 2004 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 34, 16019, 2, 789, 322 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 1, 3, 19 ]

4

true

Family

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD

LpxD

4

IPR007692

7,692

DNA helicase, DnaB type

DNA_helicase_DnaB

Family

28,082

false

This family includes the replicative DNA helicase DnaB, which exhibits DNA-dependent ATPase activity. Helicase DnaB is a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of more than 400 residues is found at a conserved ...

[ "GO:0003677", "GO:0003678", "GO:0005524", "GO:0006260" ]

[ "DNA binding", "DNA helicase activity", "ATP binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR00665" ]

[ "DnaB" ]

[ 28082 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "5.6.2.3", "GenProp0806", "GenProp1118", "GenProp1123", "GenProp1130", "GenProp1152", "GenProp1187", "GenProp1200", "GenProp1208" ]

[ "EC:5.6.2.3", "GP:GenProp0806", "GP:GenProp1118", "GP:GenProp1123", "GP:GenProp1130", "GP:GenProp1152", "GP:GenProp1187", "GP:GenProp1200", "GP:GenProp1208" ]

9

[ "2q6t", "2r6a", "2r6c", "2r6d", "2r6e", "2vye", "2vyf", "3bgw", "4esv", "4m4w", "4nmn", "4zc0", "6bbm", "6kza", "6qel", "6qem", "6t66", "7qxm", "7t20", "7t21", "7t22", "8a3v", "9dls", "9eco", "9oa1", "9oa2" ]

26

[ "PUB00019435" ]

[ "10404598" ]

[ "Crystal structure of the N-terminal domain of the DnaB hexameric helicase." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 27313, 283, 54, 432 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA helicase, DnaB type

DNA_helicase_DnaB

4

IPR007693

7,693

DNA helicase, DnaB-like, N-terminal

DNA_helicase_DnaB-like_N

Domain

34,414

false

The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-ter...

[ "GO:0003678", "GO:0005524", "GO:0006260" ]

[ "DNA helicase activity", "ATP binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF00772" ]

[ "DnaB" ]

[ 34414 ]

1

[ "EC" ]

[ "5.6.2.3" ]

[ "EC:5.6.2.3" ]

1

[ "1b79", "1jwe", "2lzn", "2q6t", "2r5u", "2r6a", "2r6c", "2r6d", "2r6e", "2vye", "2vyf", "3bgw", "3gxv", "4esv", "4m4w", "4nmn", "4zc0", "6bbm", "6qel", "6qem", "6t66", "7qxm", "7t20", "7t21", "7t22", "8a3v", "9dls", "9eco", "9oa1", "9oa2" ]

30

[ "PUB00019435", "PUB00154574" ]

[ "10404598", "7711902" ]

[ "Crystal structure of the N-terminal domain of the DnaB hexameric helicase.", "The Bacillus subtilis dnaC gene encodes a protein homologous to the DnaB helicase of Escherichia coli." ]

[ 1999, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3, 32847, 427, 381, 756 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA helicase, DnaB-like, N-terminal

DNA_helicase_DnaB-like_N

9

IPR007694

7,694

DNA helicase, DnaB-like, C-terminal

DNA_helicase_DnaB-like_C

Domain

43,007

false

This entry represents the C-terminal domain of DNAB-like helicases. DnaB helicase unwinds the DNA duplex at the Escherichia coli chromosome replication fork. The mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, however, a change in the quaternary struct...

[ "GO:0003678", "GO:0005524", "GO:0006260" ]

[ "DNA helicase activity", "ATP binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PROFILE", "CDD" ]

[ "PF03796", "PS51199", "cd00984" ]

[ "DnaB_C", "SF4_HELICASE", "DnaB_C" ]

[ 39926, 41026, 30449 ]

3

[ "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.3", "PDOC51199", "R-DME-9837999", "R-DME-9913635", "R-HSA-2151201", "R-HSA-9837999", "R-HSA-9913635", "R-MMU-9837999", "R-MMU-9913635" ]

[ "EC:5.6.2.3", "PROSITEDOC:PDOC51199", "REACTOME:R-DME-9837999", "REACTOME:R-DME-9913635", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9913635", "REACTOME:R-MMU-9837999", "REACTOME:R-MMU-9913635" ]

9

[ "1cr0", "1cr1", "1cr2", "1cr4", "1e0j", "1e0k", "1q57", "2q6t", "2r6a", "2r6c", "2r6d", "2r6e", "2vye", "2vyf", "3bgw", "3bh0", "4a1f", "4esv", "4m4w", "4nmn", "4zc0", "5ikn", "6bbm", "6kza", "6n7i", "6n7n", "6n7s", "6n7t", "6n7v", "6n9u", "6n9v", "6n9w"...

56

[ "PUB00033777", "PUB00079934", "PUB00079935" ]

[ "10645945", "10049800", "1569588" ]

[ "The bacterial replicative helicase DnaB evolved from a RecA duplication.", "Bacterial helicases.", "Organization and evolution of bacterial and bacteriophage primase-helicase systems." ]

[ 2000, 1998, 1992 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 10, 35060, 3439, 3357, 1141 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 4, 1, 1, 1, 6, 4, 5, 3, 7 ]

10

true

Domain

DNA helicase, DnaB-like, C-terminal

DNA_helicase_DnaB-like_C

3

IPR007695

7,695

DNA mismatch repair protein MutS-like, N-terminal

DNA_mismatch_repair_MutS-lik_N

Domain

40,382

false

Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The post-replicative Mismatch Repair Sys...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF01624" ]

[ "MutS_I" ]

[ 40382 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5358565", "R-BTA-5358606", "R-DDI-5358565", "R-DDI-5358606", "R-DME-5358565", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5632927", "R-HSA-5632928", "R-HSA-5632968", "R-HSA-6796648", "R-MMU-5358565", "R-MMU-5358606", "R-RNO-5358565", "R-SCE-5358565", "R-SCE-5358606", "R-SPO-53585...

[ "REACTOME:R-BTA-5358565", "REACTOME:R-BTA-5358606", "REACTOME:R-DDI-5358565", "REACTOME:R-DDI-5358606", "REACTOME:R-DME-5358565", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5632927", "REACTOME:R-HSA-5632928", "REACTOME:R-HSA-5632968", "REACTOME:R-HSA-6796648", "REACTOM...

18

[ "1e3m", "1ewq", "1fw6", "1ng9", "1nne", "1oh5", "1oh6", "1oh7", "1oh8", "1w7a", "1wb9", "1wbb", "1wbd", "2o8b", "2o8c", "2o8d", "2o8e", "2o8f", "2wtu", "3k0s", "3thw", "3thx", "3thy", "3thz", "3zlj", "5akb", "5akc", "5akd", "5x9w", "5yk4", "6i5f", "7ai5"...

61

[ "PUB00003761", "PUB00004486", "PUB00010188", "PUB00024413", "PUB00042218", "PUB00042612", "PUB00042613", "PUB00042614", "PUB00042615" ]

[ "8510668", "9722651", "8036718", "11048711", "17426027", "17919654", "17599803", "17951114", "17965091" ]

[ "The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.", "A phylogenomic study of the MutS family of proteins.", "Colon cancer and DNA repair: have mismatches met their match?", "The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.", "Escherichia coli MutS ...

[ 1993, 1998, 1994, 2000, 2007, 2007, 2007, 2008, 2007 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 811, 21227, 17770, 65, 509 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 27, 2, 15, 5, 1, 36, 14, 4, 16, 8, 4, 4, 50 ]

13

true

Domain

DNA mismatch repair protein MutS-like, N-terminal

DNA_mismatch_repair_MutS-lik_N

1

IPR007696

7,696

DNA mismatch repair protein MutS, core

DNA_mismatch_repair_MutS_core

Domain

60,477

false

This entry represents the core domain (domain 3) found in proteins of the MutS family. The core domain of MutS adopts a multi-helical structure comprised of two subdomains, which are interrupted by the clamp domain. Two of the helices in the core domain comprise the levers that extend towards the DNA. This domain is fo...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF05192", "SM00533" ]

[ "MutS_III", "MUTSd" ]

[ 47097, 58173 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5358565", "R-BTA-5358606", "R-DDI-5358565", "R-DDI-5358606", "R-DME-5358565", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5632927", "R-HSA-5632928", "R-HSA-5632968", "R-HSA-6796648", "R-HSA-912446", "R-MMU-5358565", "R-MMU-5358606", "R-RNO-5358565", "R-SCE-5358565", "R-SCE-535860...

[ "REACTOME:R-BTA-5358565", "REACTOME:R-BTA-5358606", "REACTOME:R-DDI-5358565", "REACTOME:R-DDI-5358606", "REACTOME:R-DME-5358565", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5632927", "REACTOME:R-HSA-5632928", "REACTOME:R-HSA-5632968", "REACTOME:R-HSA-6796648", "REACTOM...

19

[ "1e3m", "1ewq", "1ewr", "1fw6", "1ng9", "1nne", "1oh5", "1oh6", "1oh7", "1oh8", "1w7a", "1wb9", "1wbb", "1wbd", "2o8b", "2o8c", "2o8d", "2o8e", "2o8f", "2wtu", "3k0s", "3thw", "3thx", "3thy", "3thz", "3zlj", "5akb", "5akc", "5akd", "5x9w", "5yk4", "6i5f"...

68

[ "PUB00004486", "PUB00010188", "PUB00010189", "PUB00024413", "PUB00042218", "PUB00042612", "PUB00042613", "PUB00042614", "PUB00042615" ]

[ "9722651", "8036718", "11048710", "11048711", "17426027", "17919654", "17599803", "17951114", "17965091" ]

[ "A phylogenomic study of the MutS family of proteins.", "Colon cancer and DNA repair: have mismatches met their match?", "Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.", "The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.", "Esch...

[ 1998, 1994, 2000, 2000, 2007, 2007, 2007, 2008, 2007 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 908, 33059, 25797, 67, 646 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 48, 4, 25, 5, 1, 60, 23, 6, 20, 14, 6, 4, 62 ]

13

true

Domain

DNA mismatch repair protein MutS, core

DNA_mismatch_repair_MutS_core

3

IPR007698

7,698

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain

AlaDH/PNT_NAD(H)-bd

Domain

47,385

false

Alanine dehydrogenase catalyses the NAD-dependent reversible reductive amination of pyruvate into alanine. Pyridine nucleotide transhydrogenase catalyses the reduction of NADP + to NADPH with the concomitant oxidation of NADH to NAD + . This enzyme is located in the plasma membrane of prokaryotes and in the inner membr...

[]

0

[ "PFAM", "SMART" ]

[ "PF01262", "SM01002" ]

[ "AlaDh_PNT_C", "AlaDh_PNT_C" ]

[ 41266, 44484 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-71064", "R-BTA-71403", "R-HSA-71064", "R-HSA-71403", "R-MMU-71064", "R-MMU-71403", "R-RNO-71064" ]

[ "REACTOME:R-BTA-71064", "REACTOME:R-BTA-71403", "REACTOME:R-HSA-71064", "REACTOME:R-HSA-71403", "REACTOME:R-MMU-71064", "REACTOME:R-MMU-71403", "REACTOME:R-RNO-71064" ]

7

[ "1f8g", "1hzz", "1kol", "1l7d", "1l7e", "1nm5", "1pjb", "1pjc", "1ptj", "1say", "1u28", "1u2d", "1u2g", "1x13", "1x14", "1x15", "1xlt", "2bru", "2eez", "2fr8", "2frd", "2fsv", "2oo5", "2oor", "2q99", "2qrj", "2qrk", "2qrl", "2rir", "2vhv", "2vhw", "2vhx"...

58

[ "PUB00000218", "PUB00019119" ]

[ "8439307", "11354603" ]

[ "Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis.", "Lysine metabolism in higher plants." ]

[ 1993, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 91, 36888, 9552, 3, 851 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 3, 37, 2, 1, 13, 12, 2, 6, 14, 1, 1, 18 ]

13

true

Domain

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain

AlaDH/PNT_NAD(H)-bd

8

IPR007700

7,700

Domain of unknown function DUF668

DUF668

Domain

5,950

false

This entry represents the C-terminal domain of PSI proteins from Arabidopsis. This domain is found associated with DUF3475 ( ). PSI1 was identified as a gene that is co-expressed with the phytosulfokine (PSK) receptor genes PSKR1 and PSKR2 in Arabidopsis thaliana. PSI proteins are plant-specific and promote growth [ ].

[ "GO:0045927" ]

[ "positive regulation of growth" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05003" ]

[ "DUF668" ]

[ 5950 ]

1

[]

0

[]

0

[ "PUB00093967" ]

[ "25062973" ]

[ "The PSI family of nuclear proteins is required for growth in arabidopsis." ]

[ 2014 ]

1

[]

0

null

[ "Streptophyta" ]

[ 5950 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 41, 92 ]

3

true

Domain

Domain of unknown function DUF668

DUF668

5

IPR007701

7,701

Interferon-related developmental regulator, N-terminal

Interferon-rel_develop_reg_N

Domain

6,552

false

This entry represents the N-terminal domain of IFRD1 and similar eukaryotic sequences. Interferon-related developmental regulator (IFRD1) is the human homologue of the Rattus norvegicus early response protein PC4 and its murine homologue TIS7 [ ]. IFRD1 is a transcriptional coactivator/repressor controlling patterns of...

[]

0

[ "PFAM" ]

[ "PF05004" ]

[ "IFRD" ]

[ 6552 ]

1

[]

0

[ "6mtc", "6xu6" ]

2

[ "PUB00008660", "PUB00010173", "PUB00090213", "PUB00103871" ]

[ "9722946", "9050919", "26391411", "30355441" ]

[ "Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.", "The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chrom...

[ 1998, 1997, 2016, 2018 ]

4

[]

0

null

[ "Eukaryota", "Marinicrinis lubricantis" ]

[ 6551, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 6, 1, 3, 1, 18, 10, 1, 16, 6, 1, 29 ]

11

true

Domain

Interferon-related developmental regulator, N-terminal

Interferon-rel_develop_reg_N

1

IPR007702

7,702

Janus

Family

2,595

false

This family is comprised of the 14kDa phosphohistidine phosphatase from mammals and Janus-A/Janus-B proteins from Drosophila melanogaster. Janus-A and Janus-B regulate somatic sex differentiation and have been found to be testes specific [ ]. 14kDa phosphohistidine phosphatase is a histidine phosphatase that may play a...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05005", "PTHR12258" ]

[ "Ocnus", "" ]

[ 2594, 2400 ]

2

[]

0

[ "2ai6", "2hw4", "2nmm", "2ozw", "2ozx" ]

5

[ "PUB00010197", "PUB00068409" ]

[ "11319264", "12468887" ]

[ "Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup.", "Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 8, 2587 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 14, 3, 1, 2 ]

6

true

Family

Janus

1

IPR007703

7,703

Per os infectivity factor 3

PIF3

Family

216

false

This family contains viral proteins, and includes Baculovirus Per os infectivity factor 3 (PIF3). PIF3 forms a complex on the occlusion-derived virus surface with PIF1, PIF2, and P74 which has an essential function in the initial stages of baculovirus oral infection [ ].

[]

0

[ "PFAM" ]

[ "PF05006" ]

[ "PIF3" ]

[ 216 ]

1

[]

0

[]

0

[ "PUB00082562" ]

[ "20610731" ]

[ "Baculovirus per os infectivity factors form a complex on the surface of occlusion-derived virus." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Viruses" ]

[ 18, 198 ]

2

[]

0

true

Family

Per os infectivity factor 3

PIF3

7

IPR007704

7,704

GPI mannosyltransferase 1

PIG-M

Family

4,670

false

PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilise nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates [ ].

[ "GO:0004376", "GO:0051751", "GO:0006506", "GO:0016020" ]

[ "GPI mannosyltransferase activity", "alpha-1,4-mannosyltransferase activity", "GPI anchor biosynthetic process", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05007", "PTHR12886" ]

[ "Mannosyl_trans", "" ]

[ 4522, 4408 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

205

[]

0

[ "PUB00010183" ]

[ "11226175" ]

[ "PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "freshwater metagenome" ]

[ 10, 204, 4455, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 2, 1, 1, 1, 1, 4, 2, 1, 1, 8 ]

12

true

Family

GPI mannosyltransferase 1

PIG-M

4

IPR007705

7,705

Vesicle transport v-SNARE, N-terminal

Vesicle_trsprt_v-SNARE_N

Domain

7,587

false

v-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this [ ]. This domain is the N-terminal half of the v-SNARE proteins.

[ "GO:0006886", "GO:0016020" ]

[ "intracellular protein transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05008" ]

[ "V-SNARE" ]

[ 7587 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-114608", "R-DDI-6811438", "R-DDI-6811440", "R-HSA-114608", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-114608", "R-MMU-6811438", "R-MMU-6811440", "R-RNO-114608", "R-RNO-6811438", "R-RNO-6811440", "R-SCE-114608", "R-SCE-6811440", "R-SPO-114608", "R-SPO-6811440" ]

[ "REACTOME:R-DDI-114608", "REACTOME:R-DDI-6811438", "REACTOME:R-DDI-6811440", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-114608", "REACTOME:R-MMU-6811438", "REACTOME:R-MMU-6811440", "REACTOME:R-RNO-114608", "REACTOME:R-RNO-6811438", "REACTOME:R-...

16

[ "1vcs", "2qyw", "2v8s", "3onj", "3onl", "7xad" ]

6

[ "PUB00010242" ]

[ "10359592" ]

[ "The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 10, 7573, 2, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 1, 5, 1, 6, 11, 1, 6, 13, 1, 1, 22 ]

12

true

Domain

Vesicle transport v-SNARE, N-terminal

Vesicle_trsprt_v-SNARE_N

5

IPR007707

7,707

Transforming acidic coiled-coil-containing protein, C-terminal

TACC_C

Domain

6,665

false

This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possib...

[]

0

[ "PFAM" ]

[ "PF05010" ]

[ "TACC_C" ]

[ 6665 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9013507", "R-HSA-9604323" ]

[ "REACTOME:R-HSA-9013507", "REACTOME:R-HSA-9604323" ]

2

[ "4pky", "5lxn", "5lxo", "9opf" ]

4

[ "PUB00010236", "PUB00045149", "PUB00084761", "PUB00084766" ]

[ "11121038", "14742702", "10635326", "25262927" ]

[ "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.", "Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.", "Maskin is a CPEB-associated factor that transiently interacts with elF-4E.", ...

[ 2000, 2004, 1999, 2014 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6665 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 58, 12, 24, 22, 24 ]

6

true

Domain

Transforming acidic coiled-coil-containing protein, C-terminal

TACC_C

5

IPR007708

7,708

Lariat debranching enzyme, C-terminal

DBR1_C

Domain

4,698

false

This presumed domain is found at the C terminus of lariat debranching enzyme. This domain is always found in association with a metallo-phosphoesterase domain . RNA lariat debranching enzyme is capable of digesting a variety of branched nucleic acid substrates and multicopy single-stranded DNAs. The enzyme degrades int...

[ "GO:0016788", "GO:0006397" ]

[ "hydrolase activity, acting on ester bonds", "mRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF05011", "SM01124" ]

[ "DBR1", "DBR1" ]

[ 4697, 4493 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.4.-", "PWY-5978", "PWY-6129", "PWY-6689", "PWY-7119", "PWY-7366" ]

[ "EC:3.1.4.-", "METACYC:PWY-5978", "METACYC:PWY-6129", "METACYC:PWY-6689", "METACYC:PWY-7119", "METACYC:PWY-7366" ]

6

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4698 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 7, 4, 1, 3, 3, 1, 1, 6 ]

12

true

Domain

Lariat debranching enzyme, C-terminal

DBR1_C

8

IPR007709

7,709

N-formylglutamate amidohydrolase

N-FG_amidohydro

Family

14,938

false

Formylglutamate amidohydrolase (FGase, also known as N-formylglutamate deformylase) catalyses the terminal reaction in the five-step pathway for histidine utilization in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolysed to produce L-glutamate plus formate [ ].

[]

0

[ "PFAM" ]

[ "PF05013" ]

[ "FGase" ]

[ 14938 ]

1

[]

0

[ "2odf", "2q7s" ]

2

[ "PUB00010158" ]

[ "3308850" ]

[ "Purification and properties of formylglutamate amidohydrolase from Pseudomonas putida." ]

[ 1987 ]

1

[]

[ "IPR010247", "IPR011227" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 45, 14693, 40, 160 ]

4

[]

0

true

Family

N-formylglutamate amidohydrolase

N-FG_amidohydro

2

IPR007710

7,710

Nucleoside 2-deoxyribosyltransferase

Nucleoside_deoxyribTrfase

Family

6,352

false

Nucleoside 2-deoxyribosyltransferase (NDT) ( ) catalyses the cleavage of the glycosidic bonds of 2-deoxyribonucleosides. Nucleoside 2-deoxyribosyltransferases can be divided into two groups based on their substrate specificity: class I enzymes are specific for the transfer of deoxyribose between two purines, while clas...

[]

0

[ "PFAM" ]

[ "PF05014" ]

[ "Nuc_deoxyrib_tr" ]

[ 6352 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.2.2.-", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-7342", "PWY-7564", "PWY-8106", "R-DRE-74259", "R-HSA-74259", "R-MMU-74259", "R-RNO-74259" ]

[ "EC:3.2.2.-", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-8106", "REACTOME:R-DRE-74259", "REACTOME:R-HSA-74259", "REACTOME:R-MMU-74259", "REACTOME:R-RNO-74259" ]

11

[ "1f8x", "1f8y", "1s2d", "1s2g", "1s2i", "1s2l", "1s3f", "2a0k", "2f2t", "2f62", "2f64", "2f67", "2khz", "2klh", "4fyh", "4fyi", "4fyk", "4hx9", "4jel", "4jem", "4kxl", "4kxm", "4kxn", "4mej", "4ohr", "4p5d", "4p5e", "6evs", "6qai", "7m5h", "7o62", "8os9"...

65

[ "PUB00015073", "PUB00015074", "PUB00068837", "PUB00088377", "PUB00088378" ]

[ "14992575", "8805514", "17234634", "29273295", "11526483" ]

[ "Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution.", "Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.", "The c-Myc target gene Rcl (C6orf108) encod...

[ 2004, 1996, 2007, 2018, 2001 ]

5

[]

[ "IPR028607" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 257, 5172, 728, 73, 122 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1, 2, 1 ]

5

true

Family

Nucleoside 2-deoxyribosyltransferase

Nucleoside_deoxyribTrfase

2

IPR007711

7,711

Toxin HigB-1

HigB-1

Family

7,314

false

Bacterial toxin-antitoxin loci consist of two genes in an operon encoding a 'toxin' and an 'antitoxin' respectively. Ectopic expression of the toxins severely reduces cell growth and prevents colony formation. This entry includes HigB-1, one of the toxins found in Vibrio cholerae. It inhibits translation by sequence-sp...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05015", "PTHR40266" ]

[ "HigB-like_toxin", "" ]

[ 7288, 6654 ]

2

[ "GP", "GP" ]

[ "GenProp0321", "GenProp0322" ]

[ "GP:GenProp0321", "GP:GenProp0322" ]

2

[ "4mct", "4mcx", "4px8", "4w4g", "4ypb", "4yy3", "4yzv", "4zsn", "5iwh", "5ixl", "6f8s", "9chl", "9chn" ]

13

[ "PUB00063680", "PUB00076680", "PUB00100108", "PUB00156065" ]

[ "17020579", "17085558", "24257752", "19423702" ]

[ "Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids.", "Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae.", "Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex.", "Bacterial toxin HigB associates with ribosom...

[ 2006, 2007, 2014, 2009 ]

4

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Thermococcus litoralis", "unclassified sequences" ]

[ 7124, 7, 15, 1, 167 ]

5

[]

0

true

Family

Toxin HigB-1

HigB-1

8

IPR007712

7,712

Toxin-antitoxin system, RelE/ParE toxin family

RelE/ParE_toxin

Family

47,233

false

The RelE/ParE family encompasses several toxin components of toxin-antitoxin modules. RelE is a sequence-specific, ribosome-dependent mRNA endoribonuclease which inhibits translation during amino acid starvation [ ]. ParE is involved in plasmid partition. ParE acts by inhibiting DNA gyrase, converting supercoiled plasm...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05016", "TIGR02385" ]

[ "ParE_toxin", "RelE_StbE" ]

[ 40941, 15541 ]

2

[ "GP", "GP", "GP", "GP" ]

[ "GenProp0321", "GenProp0323", "GenProp0324", "GenProp1193" ]

[ "GP:GenProp0321", "GP:GenProp0323", "GP:GenProp0324", "GP:GenProp1193" ]

4

[ "1wmi", "1z8m", "2kc8", "2kc9", "2khe", "2otr", "3bpq", "3g5o", "3kxe", "4fxe", "4fxh", "4fxi", "4ls4", "4lsy", "4ltt", "4ml0", "4ml2", "4mmg", "4mmj", "4nrn", "4q2u", "4v7j", "4v7k", "5ceg", "5cw7", "5cze", "5czf", "6x0a", "6xrw", "7bwf", "7etr", "7r5a"...

37

[ "PUB00056596", "PUB00057357", "PUB00057358" ]

[ "15718296", "8133518", "12010492" ]

[ "Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.", "The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss.", "ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyra...

[ 2005, 1994, 2002 ]

3

[]

[ "IPR004386", "IPR028344" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 947, 45325, 43, 56, 7, 855 ]

6

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Toxin-antitoxin system, RelE/ParE toxin family

RelE/ParE_toxin

7

IPR007713

7,713

TMP repeat

TMP_rpt

Repeat

255

false

This short repeat consists of the motif WXXh where X can be any residue and h is a hydrophobic residue. The repeat is named TMP after its occurrence in the tape measure protein (TMP). Tape measure protein is a component of phage tail and probably forms a β-helix. Truncated forms of TMP lead to shortened tail fibres [ ]...

[]

0

[ "PFAM" ]

[ "PF05017" ]

[ "TMP" ]

[ 255 ]

1

[]

0

[]

0

[ "PUB00010241" ]

[ "11040123" ]

[ "Mutational analysis of two structural genes of the temperate lactococcal bacteriophage TP901-1 involved in tail length determination and baseplate assembly." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "marine sediment metagenome" ]

[ 143, 82, 27, 3 ]

4

[]

0

true

Repeat

TMP repeat

TMP_rpt

7

IPR007714

7,714

CFA20 domain

CFA20_dom

Domain

8,476

false

This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [ , ]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a sc...

[]

0

[ "PFAM" ]

[ "PF05018" ]

[ "CFA20_dom" ]

[ 8476 ]

1

[]

0

[ "6u42", "6ve7", "7rro", "7som", "7ung", "8g2z", "8g3d", "8glv", "8i7o", "8i7r", "8iyj", "8j07", "8otz", "8sf7", "8snb", "8tek", "8tid", "8to0", "9cpb", "9cpc", "9d5n", "9e2g", "9e5c", "9e78", "9fqr", "9ijj" ]

26

[ "PUB00072946", "PUB00072975", "PUB00072976" ]

[ "20118210", "24574454", "24259666" ]

[ "Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.", "FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas.", "The conserve...

[ 2010, 2014, 2014 ]

3

[]

0

null

[ "Eukaryota", "hydrothermal vent metagenome" ]

[ 8475, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 8, 3, 10, 8, 3, 13, 6 ]

9

true

Domain

CFA20 domain

CFA20_dom

1

IPR007716

7,716

NPL4, zinc-binding putative

NPL4_Zn-bd_put

Domain

4,145

false

The HRD4 gene is identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their re...

[]

0

[ "PFAM" ]

[ "PF05020" ]

[ "zf-NPL4" ]

[ 4145 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-110320", "R-CEL-8951664", "R-CEL-9755511", "R-DME-110320", "R-DME-8951664", "R-DME-9755511", "R-HSA-110320", "R-HSA-8951664", "R-HSA-9755511", "R-MMU-110320", "R-MMU-8951664", "R-MMU-9755511", "R-RNO-110320", "R-RNO-8951664", "R-RNO-9755511", "R-SCE-110320", "R-SCE-8951664", ...

[ "REACTOME:R-CEL-110320", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-9755511", "REACTOME:R-DME-110320", "REACTOME:R-DME-8951664", "REACTOME:R-DME-9755511", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9755511", "REACTOME:R-MMU-110320", "REACTOME:R-MMU-8951664", "REACTOME:R-...

21

[ "6cdd", "6chs", "6jwh", "6jwi", "6jwj", "6oa9", "6oaa", "7wwp", "7wwq", "8dar", "8das", "8dat", "8dau", "8dav", "8daw", "9ofv" ]

16

[ "PUB00010193" ]

[ "11739805" ]

[ "HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4145 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 1, 1, 4, 4, 2, 7, 1, 1 ]

9

true

Domain

NPL4, zinc-binding putative

NPL4_Zn-bd_put

4

IPR007717

7,717

Nuclear pore localisation protein NPL4, C-terminal

NPL4_C

Domain

5,430

false

The HRD4 gene is identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation following ubiquitination of target proteins but preceding t...

[]

0

[ "PFAM", "CDD" ]

[ "PF05021", "cd08061" ]

[ "NPL4", "MPN_NPL4" ]

[ 5418, 4959 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-110320", "R-CEL-8951664", "R-CEL-9755511", "R-DDI-8951664", "R-DDI-9755511", "R-DME-110320", "R-DME-8951664", "R-DME-9755511", "R-HSA-110320", "R-HSA-8951664", "R-HSA-9755511", "R-MMU-110320", "R-MMU-8951664", "R-MMU-9755511", "R-RNO-110320", "R-RNO-8951664", "R-RNO-9755511", ...

[ "REACTOME:R-CEL-110320", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-9755511", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-9755511", "REACTOME:R-DME-110320", "REACTOME:R-DME-8951664", "REACTOME:R-DME-9755511", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9755511", "REACTOME:R...

23

[ "6cdd", "6chs", "6jwh", "6jwi", "6jwj", "6oa9", "6oaa", "7wwp", "7wwq", "8dar", "8das", "8dat", "8dau", "8dav", "8daw", "9m3z", "9ofv" ]

17

[ "PUB00010193", "PUB00019939" ]

[ "11739805", "11574150" ]

[ "HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins.", "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5430 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 1, 1, 6, 4, 2, 2, 7, 1, 1, 10 ]

12

true

Domain

Nuclear pore localisation protein NPL4, C-terminal

NPL4_C

8

IPR007718

7,718

Srp40, C-terminal

Srp40_C

Domain

4,259

false

This presumed domain is found at the C terminus of the budding yeast Srp40 and mammalian NOLC1 (also known as Nopp140) proteins. They are nucleolar proteins that contain a central domain consisting of ten repeats of acidic serine clusters alternating with lysine-, alanine- and proline-rich basic stretches [ ]. Srp40 ma...

[]

0

[ "PFAM" ]

[ "PF05022" ]

[ "SRP40_C" ]

[ 4259 ]

1

[]

0

[]

0

[ "PUB00020370", "PUB00089266", "PUB00089267", "PUB00089268" ]

[ "9364927", "10567578", "26399832", "22906532" ]

[ "The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton.", "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organizatio...

[ 1997, 1999, 2015, 2013 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4259 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 5, 2, 4, 4, 1, 4, 3, 1, 1, 10 ]

12

true

Domain

Srp40, C-terminal

Srp40_C

4

IPR007719

7,719

Phytochelatin synthase, N-terminal catalytic domain

PCS_N

Domain

3,344

false

Phytochelatins are well known as the heavy metal-detoxifying peptides in higher plants, eukaryotic algae, fungi, nematode and cyanobacteria. Phytochelatin synthase (PCS, also known as glutathione gamma-glutamylcysteinyltransferase; ) is involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC). This...

[ "GO:0016756", "GO:0046872", "GO:0010038", "GO:0046938" ]

[ "glutathione gamma-glutamylcysteinyltransferase activity", "metal ion binding", "response to metal ion", "phytochelatin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PFAM", "PROFILE" ]

[ "PF05023", "PS51443" ]

[ "Phytochelatin", "PCS" ]

[ 3220, 3261 ]

2

[ "EC", "METACYC" ]

[ "2.3.2.15", "PWY-6745" ]

[ "EC:2.3.2.15", "METACYC:PWY-6745" ]

2

[ "2btw", "2bu3", "6th5", "6tho", "6tjl" ]

5

[ "PUB00039759", "PUB00044775" ]

[ "16339904", "18270423" ]

[ "A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis.", "Chelation of cadmium ions by phytochelatin synthase: role of the cysteine-rich C-terminal." ]

[ 2005, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanoculleus thermophilus", "metagenomes" ]

[ 687, 2651, 1, 5 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 9, 1, 16, 1, 6 ]

5

true

Domain

Phytochelatin synthase, N-terminal catalytic domain

PCS_N

2

IPR007720

7,720

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1

PigQ/GPI1

Family

5,008

false

Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four gen...

[ "GO:0006506", "GO:0016020" ]

[ "GPI anchor biosynthetic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05024", "PTHR21329" ]

[ "Gpi1", "" ]

[ 4903, 3980 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-162710", "R-MMU-162710" ]

[ "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710" ]

2

[]

0

[ "PUB00010167", "PUB00019646", "PUB00100133" ]

[ "11849707", "8910381", "10373468" ]

[ "The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant.", "Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.", "GPI1 stabilizes an enzyme essential in the first step of glycosylphosp...

[ 2002, 1996, 1999 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5008 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 3, 3, 13, 14, 1, 3, 3, 1, 1, 8 ]

12

true

Family

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1

PigQ/GPI1

6

IPR007721

7,721

D-ribose pyranase RbsD/L-fucose mutarotase FucU

RbsD_FucU

Family

11,838

false

RbsD is a component of the ribose operon. It was originally thought to be a high affinity ribose transport protein, but further analysis [ ] shows that it is a D-ribose pyranase . It catalyses the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose ...

[ "GO:0016853", "GO:0048029", "GO:0005996" ]

[ "isomerase activity", "monosaccharide binding", "monosaccharide metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05025" ]

[ "RbsD_FucU" ]

[ 11838 ]

1

[ "EC", "GP", "GP", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.4.99.62", "GenProp0458", "GenProp1680", "R-DRE-6787639", "R-HSA-6787639", "R-MMU-6787639" ]

[ "EC:5.4.99.62", "GP:GenProp0458", "GP:GenProp1680", "REACTOME:R-DRE-6787639", "REACTOME:R-HSA-6787639", "REACTOME:R-MMU-6787639" ]

6

[ "1ogc", "1ogd", "1oge", "1ogf", "2ob5", "2wcu", "2wcv", "3e7n", "3mvk", "3p12", "3p13", "4a34" ]

12

[ "PUB00053834" ]

[ "16731978" ]

[ "Stepwise disassembly and apparent nonstepwise reassembly for the oligomeric RbsD protein." ]

[ 2006 ]

1

[]

[ "IPR023064", "IPR023751" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8, 10895, 820, 115 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4, 5, 10 ]

6

true

Family

D-ribose pyranase RbsD/L-fucose mutarotase FucU

RbsD_FucU

4

IPR007722

7,722

mRNA decapping protein 2, Box A domain

DCP2_BoxA

Domain

4,528

false

This presumed domain is always found to the N-terminal side of the NUDIX hydrolase domain . This domain appears to be specific to mRNA decapping protein 2 (DCP2) and its close homologues. This region has been termed Box A [ ].

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF05026", "SM01125" ]

[ "DCP2", "DCP2" ]

[ 4498, 4485 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.1.62", "R-CEL-430039", "R-CEL-450385", "R-CEL-450513", "R-HSA-380994", "R-HSA-430039", "R-HSA-450385", "R-HSA-450513", "R-HSA-450604", "R-MMU-430039", "R-MMU-450385", "R-MMU-450513", "R-MMU-450604", "R-SCE-430039", "R-SCE-450385", "R-SCE-450513" ]

[ "EC:3.6.1.62", "REACTOME:R-CEL-430039", "REACTOME:R-CEL-450385", "REACTOME:R-CEL-450513", "REACTOME:R-HSA-380994", "REACTOME:R-HSA-430039", "REACTOME:R-HSA-450385", "REACTOME:R-HSA-450513", "REACTOME:R-HSA-450604", "REACTOME:R-MMU-430039", "REACTOME:R-MMU-450385", "REACTOME:R-MMU-450513", "R...

16

[ "2a6t", "2qkl", "2qkm", "5j3t", "5j3y", "5kq1", "5kq4", "5lon", "5lop", "5n2v", "6am0", "6y3z" ]

12

[ "PUB00010148" ]

[ "12218187" ]

[ "The hDcp2 protein is a mammalian mRNA decapping enzyme." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4528 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 3, 2, 3, 1, 3, 4, 1, 1, 17 ]

12

true

Domain

mRNA decapping protein 2, Box A domain

DCP2_BoxA

4

IPR007724

7,724

Poly(ADP-ribose) glycohydrolase

Poly_GlycHdrlase

Family

5,569

false

Poly(ADP-ribose) glycohydrolase (PARG) ( ) is a ubiquitously expressed exo- and endoglycohydrolase which catalyses the hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) [ , , , , ]. It generates mono-ADP-ribosylated proteins in cells, due to its ability of degradi...

[ "GO:0004649", "GO:0005975", "GO:0006282" ]

[ "poly(ADP-ribose) glycohydrolase activity", "carbohydrate metabolic process", "regulation of DNA repair" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PANTHER" ]

[ "PTHR12837" ]

[ "" ]

[ 5569 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.2.1.143", "R-DME-110362", "R-HSA-110362", "R-MMU-110362", "R-RNO-110362" ]

[ "EC:3.2.1.143", "REACTOME:R-DME-110362", "REACTOME:R-HSA-110362", "REACTOME:R-MMU-110362", "REACTOME:R-RNO-110362" ]

5

[ "3uek", "3uel", "4a0d", "4b1g", "4b1h", "4b1i", "4b1j", "4epp", "4epq", "4fc2", "4l2h", "4n9y", "4n9z", "4na0", "4na4", "4na5", "4na6", "5a7r", "5lhb", "6hh6", "6hmk", "6hml", "6hmm", "6hmn", "6o9x", "6o9y", "6oa0", "6oa1", "6oa3", "6oak", "6oal", "7kfp"...

39

[ "PUB00010199", "PUB00064006", "PUB00100178", "PUB00100423", "PUB00100424", "PUB00100425", "PUB00100426", "PUB00100427", "PUB00100428" ]

[ "11593040", "23251397", "22609859", "33186521", "34019811", "34321462", "27257257", "34592134", "26516022" ]

[ "Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death.", "Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives.", "Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible...

[ 2001, 2012, 2012, 2020, 2021, 2021, 2016, 2021, 2015 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "viral metagenome" ]

[ 22, 5530, 14, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 9, 15, 1, 6, 6, 5, 8, 6 ]

9

true

Family

Poly(ADP-ribose) glycohydrolase

Poly_GlycHdrlase

9

IPR007725

7,725

Timeless, PAB domain

TIMELESS_PAB

Domain

3,424

false

This entry represents the PAB (PARP-1-binding domain) domain found in the Timeless (TIM) proteins [ ]. This domain can be found in TIM homologues mostly from animals. This domain found in hTIM has been shown to bind to the PARP-1 catalytic domain [ ]. The timeless gene in Drosophila melanogaster is involved in circadia...

[]

0

[ "PFAM" ]

[ "PF05029" ]

[ "TIMELESS_C" ]

[ 3424 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-432395", "R-DME-432490", "R-DME-432501", "R-DME-432553", "R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-MMU-5693607", "R-RNO-5693607" ]

[ "REACTOME:R-DME-432395", "REACTOME:R-DME-432490", "REACTOME:R-DME-432501", "REACTOME:R-DME-432553", "REACTOME:R-DME-432620", "REACTOME:R-DME-538898", "REACTOME:R-HSA-5693607", "REACTOME:R-MMU-5693607", "REACTOME:R-RNO-5693607" ]

9

[ "4xht", "4xhu", "4xhw", "6skl", "7pfo", "7plo", "7pmk", "7pmn", "8b9a", "8b9b", "8b9c", "8b9d", "8dd7", "8kg6", "8xgc", "9e2w", "9e2x" ]

17

[ "PUB00008650", "PUB00010237", "PUB00016387", "PUB00045036", "PUB00093466", "PUB00097687", "PUB00097689", "PUB00097690", "PUB00097691", "PUB00097692" ]

[ "11710984", "11237000", "15367656", "12944972", "26344098", "19819872", "23418588", "10417378", "10899011", "32469068" ]

[ "Flies, clocks and evolution.", "Keeping time with the human genome.", "Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.", "S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.", "Timeless Interacts with PARP-1 to Promote Homologous Reco...

[ 2001, 2001, 2004, 2003, 2015, 2009, 2013, 1999, 2000, 2020 ]

10

[]

0

null

[ "Eukaryota" ]

[ 3424 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 6, 3, 3, 1, 4, 1, 1 ]

8

true

Domain

Timeless, PAB domain

TIMELESS_PAB

4

IPR007726

7,726

SS18, N-terminal

SS18_N

Domain

6,115

false

This entry represents the N-terminal domain of SS18 and related proteins. SSXT (also known as SS18) appears to function synergistically with RBM14 as a transcriptional coactivator [ ]. The SSXT protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) ...

[]

0

[ "PFAM" ]

[ "PF05030" ]

[ "SSXT" ]

[ 6115 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9933937", "R-BTA-9933947", "R-HSA-9824585", "R-HSA-9845323", "R-HSA-9933937", "R-HSA-9933946", "R-HSA-9933947", "R-HSA-9934037", "R-MMU-9933937", "R-MMU-9933946", "R-MMU-9933947", "R-MMU-9934037", "R-RNO-9933937", "R-RNO-9933947" ]

[ "REACTOME:R-BTA-9933937", "REACTOME:R-BTA-9933947", "REACTOME:R-HSA-9824585", "REACTOME:R-HSA-9845323", "REACTOME:R-HSA-9933937", "REACTOME:R-HSA-9933946", "REACTOME:R-HSA-9933947", "REACTOME:R-HSA-9934037", "REACTOME:R-MMU-9933937", "REACTOME:R-MMU-9933946", "REACTOME:R-MMU-9933947", "REACTOM...

14

[ "7vrb" ]

1

[ "PUB00010223", "PUB00053835", "PUB00053836", "PUB00053837", "PUB00068030" ]

[ "12173050", "15919756", "14716005", "19081374", "19648231" ]

[ "The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery.", "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.", "Dendrite development regulated by CREST, a calcium-regul...

[ 2002, 2005, 2004, 2008, 2009 ]

5

[]

0

null

[ "Eukaryota" ]

[ 6115 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 1, 3, 2, 29, 15, 6, 15, 11 ]

9

true

Domain

SS18, N-terminal

SS18_N

6

IPR007727

7,727

Spo12

Family

1,693

false

This entry includes budding yeast Spo12 and its paralogue, Bns1, that arose from the whole genome duplication. Spo12 plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive [ ]. Spo12 is a nuclear protein [ ]. Spo12 is a componen...

[]

0

[ "PFAM" ]

[ "PF05032" ]

[ "Spo12" ]

[ 1693 ]

1

[]

0

[]

0

[ "PUB00010231", "PUB00010232", "PUB00010233" ]

[ "11729145", "11278742", "11832211" ]

[ "The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex.", "Nuclear import of Spo12p, a protein essential for meiosis.", "Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network...

[ 2001, 2001, 2002 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1693 ]

1

[ "Caenorhabditis elegans", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 1 ]

4

true

Family

Spo12

6

IPR007728

7,728

Pre-SET domain

Pre-SET_dom

Domain

20,995

false

This region is found in a number of histone lysine methyltransferases (HMTase), N-terminal to the SET domain; it is generally described as the pre-SET domain. Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. Histone lysine methyltransferas...

[ "GO:0008270", "GO:0042054", "GO:0005634" ]

[ "zinc ion binding", "histone methyltransferase activity", "nucleus" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05033", "PS50867", "SM00468" ]

[ "Pre-SET", "PRE_SET", "PreSET" ]

[ 19704, 19486, 19074 ]

3

[ "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.1.1", "PDOC50280", "R-CEL-3214841", "R-DME-3214841", "R-DME-427359", "R-DME-9843940", "R-DRE-3214841", "R-DRE-9843940", "R-DRE-9843970", "R-HSA-2559582", "R-HSA-3214841", "R-HSA-427359", "R-HSA-427389", "R-HSA-6804760", "R-HSA-73762", "R-HSA-8853884", "R-HSA-8953750", "R-HSA-984...

[ "EC:2.1.1", "PROSITEDOC:PDOC50280", "REACTOME:R-CEL-3214841", "REACTOME:R-DME-3214841", "REACTOME:R-DME-427359", "REACTOME:R-DME-9843940", "REACTOME:R-DRE-3214841", "REACTOME:R-DRE-9843940", "REACTOME:R-DRE-9843970", "REACTOME:R-HSA-2559582", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-427359", ...

25

[ "1ml9", "1mvh", "1mvx", "1peg", "2igq", "2o8j", "2r3a", "2rfi", "3bo5", "3fpd", "3hna", "3k5k", "3mo0", "3mo2", "3mo5", "3rjw", "3sw9", "3swc", "4i51", "4nj5", "4nvq", "4qen", "4qeo", "4qep", "5jhn", "5jin", "5jiy", "5jj0", "5t0k", "5t0m", "5ttf", "5ttg"...

68

[ "PUB00010205", "PUB00015425", "PUB00018235", "PUB00029363", "PUB00029821", "PUB00033352", "PUB00033353" ]

[ "12389037", "11691919", "12372305", "12540855", "12887903", "12123582", "11893494" ]

[ "Structure of the SET domain histone lysine methyltransferase Clr4.", "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes.", "Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyl...

[ 2002, 2001, 2002, 2003, 2003, 2002, 2002 ]

7

[]

0

null

[ "Eukaryota" ]

[ 20995 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 75, 3, 102, 9, 27, 32, 1, 45, 36, 1, 100 ]

11

true

Domain

Pre-SET domain

Pre-SET_dom

2

IPR007729

7,729

2-keto-3-deoxy-galactonokinase

DGOK

Family

6,124

false

2-keto-3-deoxy-galactonokinase is a bacterial transferase that catalyses the second step in D-galactonate degradation. ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate D-Galactonate is catabolized in saprophytic mycobacteria to give pyruvate and glyceraldehyde-3-phosphate by a p...

[ "GO:0008671", "GO:0034194" ]

[ "2-dehydro-3-deoxygalactonokinase activity", "D-galactonate catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05035" ]

[ "DGOK" ]

[ 6124 ]

1

[ "GP" ]

[ "GenProp1566" ]

[ "GP:GenProp1566" ]

1

[ "3r1x", "3t69" ]

2

[ "PUB00019410" ]

[ "7287628" ]

[ "Pathway for D-galactonate catabolism in nonpathogenic mycobacteria." ]

[ 1981 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6087, 6, 31 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

2-keto-3-deoxy-galactonokinase

DGOK

1

IPR007730

7,730

Sporulation-like domain

SPOR-like_dom

Domain

49,777

false

This 70 residue domain, known as SPOR domain, is composed of two 35 residue repeats that are found in bacterial proteins involved in sporulation and cell division, such as FtsN, CwlM and RlpA. The SPOR domains in the FtsN cell division proteins from Escherichia coli and Caulobacter crescentus have been shown to bind pe...

[ "GO:0042834" ]

[ "peptidoglycan binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05036", "PS51724" ]

[ "SPOR", "SPOR" ]

[ 48278, 43989 ]

2

[]

0

[ "1uta", "1x60", "2lfv", "6i05", "6i09", "6i0a", "6i0n", "6ozd", "6ztg" ]

9

[ "PUB00003751", "PUB00009978", "PUB00014942", "PUB00077005", "PUB00077033", "PUB00097385" ]

[ "1495475", "3316191", "15101973", "19880599", "26305949", "25496160" ]

[ "Genetic structure, isolation and characterization of a Bacillus licheniformis cell wall hydrolase.", "Genes encoding two lipoproteins in the leuS-dacA region of the Escherichia coli chromosome.", "Solution structure and domain architecture of the divisome protein FtsN.", "Discovery and characterization of th...

[ 1992, 1987, 2004, 2010, 2015, 2015 ]

6

[]

0

null

[ "Bacteria", "Candidatus Methanogaster sp.", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 48912, 1, 65, 34, 765 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

Sporulation-like domain

SPOR-like_dom

3

IPR007731

7,731

Protein of unknown function DUF669

DUF669

Family

1,427

false

Members of this family are found in various phages and bacteria.

[]

0

[ "PFAM" ]

[ "PF05037" ]

[ "DUF669" ]

[ 1427 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Durusdinium trenchii", "Viruses", "metagenomes" ]

[ 1052, 1, 1, 312, 61 ]

5

[]

0

true

Family

Protein of unknown function DUF669

DUF669

4

IPR007732

7,732

Cytochrome b558 alpha-subunit

Cyt_b558_asu

Family

963

false

Flavocytochrome b558 is the catalytic core of the respiratory-burst oxidase, an enzyme complex that catalyzes the NADPH-dependent reduction of O2 into the superoxide anion O2 in phagocytic cells. Flavocytochrome b558 is anchored in the plasma membrane. It is a heterodimer that consists of a large glycoprotein gp91phox ...

[ "GO:0020037" ]

[ "heme binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05038", "PIRSF019635", "PTHR15168" ]

[ "Cytochrom_B558a", "Cytochr_b558a", "" ]

[ 960, 354, 940 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1222556", "R-BTA-1236973", "R-BTA-3299685", "R-BTA-4420097", "R-BTA-5668599", "R-BTA-6798695", "R-BTA-9013149", "R-BTA-9013404", "R-BTA-9013423", "R-HSA-1222556", "R-HSA-1236973", "R-HSA-3299685", "R-HSA-4420097", "R-HSA-5668599", "R-HSA-6798695", "R-HSA-9013149", "R-HSA-90134...

[ "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-1236973", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-4420097", "REACTOME:R-BTA-5668599", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9013149", "REACTOME:R-BTA-9013404", "REACTOME:R-BTA-9013423", "REACTOME:R-HSA-1222556", "REACTOME:R-HSA-1236973", "REACTOM...

36

[ "7u8g", "8gz3", "8kei", "8wej", "8x2l" ]

5

[ "PUB00010247" ]

[ "8798532" ]

[ "p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells." ]

[ 1996 ]

1

[]

0

null

[ "Candidatus Ryanbacteria bacterium RIFCSPHIGHO2_01_FULL_45_22", "Eukaryota" ]

[ 1, 962 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 14, 4, 4 ]

4

true

Family

Cytochrome b558 alpha-subunit

Cyt_b558_asu

2

IPR007734

7,734

Heparan sulphate 2-O-sulfotransferase

Heparan_SO4_2-O-STrfase

Family

4,438

false

Heparan sulphate (HS) is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix, where it acts as a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS-O-sulphotransferase (Hs2st) occupies a critical position in th...

[ "GO:0008146", "GO:0016020" ]

[ "sulfotransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12129" ]

[ "" ]

[ 4438 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.2.-", "PWY-6546", "PWY-6558", "PWY-6567", "PWY-6568", "PWY-7831", "PWY-8045", "PWY-8358", "PWY-8381", "R-CEL-2022928", "R-DME-2022870", "R-DME-2022923", "R-DME-2022928", "R-GGA-2022928", "R-HSA-2022870", "R-HSA-2022923", "R-HSA-2022928", "R-MMU-2022870", "R-MMU-2022923", "...

[ "EC:2.8.2.-", "METACYC:PWY-6546", "METACYC:PWY-6558", "METACYC:PWY-6567", "METACYC:PWY-6568", "METACYC:PWY-7831", "METACYC:PWY-8045", "METACYC:PWY-8358", "METACYC:PWY-8381", "REACTOME:R-CEL-2022928", "REACTOME:R-DME-2022870", "REACTOME:R-DME-2022923", "REACTOME:R-DME-2022928", "REACTOME:R-...

20

[]

0

[ "PUB00010170", "PUB00158970", "PUB00158971" ]

[ "11956326", "10187838", "17227754" ]

[ "Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.", "Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in der...

[ 2002, 1999, 2007 ]

3

[ "IPR005331" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 51, 4384, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 8, 2, 8, 3, 7 ]

6

true

Family

Heparan sulphate 2-O-sulfotransferase

Heparan_SO4_2-O-STrfase

9

IPR007735

7,735

Pecanex, C-terminal

Pecanex_C

Domain

5,591

false

This entry represents the C-terminal domain of pecanex protein. The pecanex protein is a maternal-effect neurogenic gene found in Drosophila [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05041" ]

[ "Pecanex_C" ]

[ 5591 ]

1

[]

0

[]

0

[ "PUB00010201" ]

[ "1460533" ]

[ "A mammalian homologue of a transcript from the Drosophila pecanex locus." ]

[ 1992 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5591 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 11, 3, 9, 12, 18 ]

6

true

Domain

Pecanex, C-terminal

Pecanex_C

6

IPR007736

7,736

Caleosin-related

Family

4,657

false

Caleosins are a family of lipid-associated proteins that are ubiquitous in plants and true fungi. In plants, caleosinss are Ca(2+)-binding oil-body surface proteins [ ]. Later, caleosin was identified as a putative peroxygenase, which is involved in oxylipin metabolism during biotic and abiotic stress responses in Arab...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05042", "PTHR31495" ]

[ "Caleosin", "" ]

[ 4652, 4540 ]

2

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.11.2.3", "PWY-321", "PWY-5410", "PWY-6917" ]

[ "EC:1.11.2.3", "METACYC:PWY-321", "METACYC:PWY-5410", "METACYC:PWY-6917" ]

4

[]

0

[ "PUB00075528", "PUB00075529" ]

[ "16961733", "19467604" ]

[ "A role for caleosin in degradation of oil-body storage lipid during seed germination.", "Roles of a membrane-bound caleosin and putative peroxygenase in biotic and abiotic stress responses in Arabidopsis." ]

[ 2006, 2009 ]

2

[]

0

null

[ "Bacteria", "Edafosvirus sp.", "Eukaryota" ]

[ 21, 1, 4635 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 1, 33, 64 ]

4

true

Family

Caleosin-related

3