LiteFold/InterPro · Datasets at Hugging Face

IPR007859

7,859

ETF-QO/FixX, C-terminal domain

ETF-QO/FixX_C

Domain

14,895

false

This domain is found at the C-terminal of Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO), which accepts electrons from a electron-transfer flavoprotein that is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4F...

[ "GO:0051536" ]

[ "iron-sulfur cluster binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05187" ]

[ "Fer4_ETF_QO" ]

[ 14895 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.5.5.1", "R-CEL-611105", "R-DDI-611105", "R-HSA-611105", "R-MMU-611105", "R-RNO-611105", "R-SCE-611105", "R-SPO-611105" ]

[ "EC:1.5.5.1", "REACTOME:R-CEL-611105", "REACTOME:R-DDI-611105", "REACTOME:R-HSA-611105", "REACTOME:R-MMU-611105", "REACTOME:R-RNO-611105", "REACTOME:R-SCE-611105", "REACTOME:R-SPO-611105" ]

8

[ "2gmh", "2gmj", "7koe" ]

3

[ "PUB00010157" ]

[ "8306995" ]

[ "Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase." ]

[ 1994 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 95, 9798, 4861, 141 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 13, 2, 1, 3, 8, 1, 1, 8 ]

12

true

Domain

ETF-QO/FixX, C-terminal domain

ETF-QO/FixX_C

5

IPR007860

7,860

DNA mismatch repair protein MutS, connector domain

DNA_mmatch_repair_MutS_con_dom

Domain

37,043

false

This entry represents the connector domain (domain 2) found in proteins of the MutS family. The structure of the MutS connector domain consists of a parallel β-sheet surrounded by four α helices, which is similar to the structure of the Holliday junction resolvase ruvC. Mismatch repair contributes to the overall fideli...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05188" ]

[ "MutS_II" ]

[ 37043 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5358565", "R-BTA-5358606", "R-DDI-5358565", "R-DDI-5358606", "R-DME-5358565", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5632927", "R-HSA-5632928", "R-HSA-5632968", "R-HSA-6796648", "R-HSA-912446", "R-MMU-5358565", "R-MMU-5358606", "R-RNO-5358565", "R-SCE-5358565", "R-SCE-535860...

[ "REACTOME:R-BTA-5358565", "REACTOME:R-BTA-5358606", "REACTOME:R-DDI-5358565", "REACTOME:R-DDI-5358606", "REACTOME:R-DME-5358565", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5632927", "REACTOME:R-HSA-5632928", "REACTOME:R-HSA-5632968", "REACTOME:R-HSA-6796648", "REACTOM...

19

[ "1e3m", "1ewq", "1ewr", "1fw6", "1ng9", "1nne", "1oh5", "1oh6", "1oh7", "1oh8", "1w7a", "1wb9", "1wbb", "1wbd", "2o8b", "2o8c", "2o8d", "2o8e", "2o8f", "2wtu", "3k0s", "3thw", "3thx", "3thy", "3thz", "3zlj", "5akb", "5akc", "5akd", "5x9w", "5yk4", "6i5f"...

62

[ "PUB00004486", "PUB00010188", "PUB00024413", "PUB00042218", "PUB00042612", "PUB00042613", "PUB00042614", "PUB00042615" ]

[ "9722651", "8036718", "11048711", "17426027", "17919654", "17599803", "17951114", "17965091" ]

[ "A phylogenomic study of the MutS family of proteins.", "Colon cancer and DNA repair: have mismatches met their match?", "The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.", "Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramer...

[ 1998, 1994, 2000, 2007, 2007, 2007, 2008, 2007 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 805, 19945, 16029, 264 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 23, 1, 21, 5, 1, 35, 18, 4, 7, 10, 5, 4, 30 ]

13

true

Domain

DNA mismatch repair protein MutS, connector domain

DNA_mmatch_repair_MutS_con_dom

3

IPR007861

7,861

DNA mismatch repair protein MutS, clamp

DNA_mismatch_repair_MutS_clamp

Domain

36,246

false

Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The post-replicative Mismatch Repair Sys...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05190" ]

[ "MutS_IV" ]

[ 36246 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5358565", "R-BTA-5358606", "R-DDI-5358565", "R-DDI-5358606", "R-DME-5358565", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5632927", "R-HSA-5632928", "R-HSA-5632968", "R-HSA-6796648", "R-HSA-912446", "R-MMU-5358565", "R-MMU-5358606", "R-RNO-5358565", "R-SCE-5358565", "R-SCE-535860...

[ "REACTOME:R-BTA-5358565", "REACTOME:R-BTA-5358606", "REACTOME:R-DDI-5358565", "REACTOME:R-DDI-5358606", "REACTOME:R-DME-5358565", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5632927", "REACTOME:R-HSA-5632928", "REACTOME:R-HSA-5632968", "REACTOME:R-HSA-6796648", "REACTOM...

19

[ "1e3m", "1ewq", "1ewr", "1fw6", "1ng9", "1nne", "1oh5", "1oh6", "1oh7", "1oh8", "1w7a", "1wb9", "1wbb", "1wbd", "2o8b", "2o8c", "2o8d", "2o8e", "2o8f", "2wtu", "3k0s", "3thw", "3thx", "3thy", "3thz", "3zlj", "5akb", "5akc", "5akd", "5x9w", "5yk4", "6i5f"...

62

[ "PUB00004486", "PUB00010188", "PUB00010189", "PUB00024413", "PUB00042218", "PUB00042612", "PUB00042613", "PUB00042614", "PUB00042615" ]

[ "9722651", "8036718", "11048710", "11048711", "17426027", "17919654", "17599803", "17951114", "17965091" ]

[ "A phylogenomic study of the MutS family of proteins.", "Colon cancer and DNA repair: have mismatches met their match?", "Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.", "The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.", "Esch...

[ 1998, 1994, 2000, 2000, 2007, 2007, 2007, 2008, 2007 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 811, 20243, 14922, 270 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 23, 3, 18, 5, 1, 47, 15, 3, 8, 12, 4, 3, 37 ]

13

true

Domain

DNA mismatch repair protein MutS, clamp

DNA_mismatch_repair_MutS_clamp

3

IPR007862

7,862

Adenylate kinase, active site lid domain

Adenylate_kinase_lid-dom

Domain

29,269

false

Adenylate kinases (ADK; ) are phosphotransferases that catalyse the Mg-dependent reversible conversion of ATP and AMP to two molecules of ADP, an essential reaction for many processes in living cells. In large variants of adenylate kinase, the AMP and ATP substrates are buried in a domain that undergoes conformational ...

[ "GO:0004017" ]

[ "AMP kinase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05191" ]

[ "ADK_lid" ]

[ 29269 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.4", "2.7.4.3", "PWY-7219", "R-BTA-499943", "R-BTA-983231", "R-CEL-499943", "R-DDI-499943", "R-DDI-983231", "R-DME-499943", "R-DME-983231", "R-DRE-499943", "R-HSA-499943", "R-HSA-983231", "R-MMU-499943", "R-MMU-983231", "R-PFA-499943", "R-PFA-983231", "R-RNO-499943", "R-RNO-9...

[ "EC:2.7.4", "EC:2.7.4.3", "METACYC:PWY-7219", "REACTOME:R-BTA-499943", "REACTOME:R-BTA-983231", "REACTOME:R-CEL-499943", "REACTOME:R-DDI-499943", "REACTOME:R-DDI-983231", "REACTOME:R-DME-499943", "REACTOME:R-DME-983231", "REACTOME:R-DRE-499943", "REACTOME:R-HSA-499943", "REACTOME:R-HSA-98323...

23

[ "1ak2", "1ake", "1aky", "1ank", "1dvr", "1e4v", "1e4y", "1p3j", "1s3g", "1zd8", "1zin", "1zio", "1zip", "2ak2", "2ak3", "2aky", "2ar7", "2bbw", "2c9y", "2eck", "2eu8", "2oo7", "2ori", "2osb", "2p3s", "2qaj", "3aky", "3be4", "3dkv", "3dl0", "3fb4", "3gmt"...

82

[ "PUB00010133", "PUB00042567" ]

[ "9715904", "17299745" ]

[ "Crystal structures of Bacillus stearothermophilus adenylate kinase with bound Ap5A, Mg2+ Ap5A, and Mn2+ Ap5A reveal an intermediate lid position and six coordinate octahedral geometry for bound Mg2+ and Mn2+.", "Essential dynamics sampling study of adenylate kinase: comparison to citrate synthase and implication...

[ 1998, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 456, 18034, 10439, 340 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 2, 4, 2, 2, 13, 9, 2, 2, 11, 2, 1, 13 ]

13

true

Domain

Adenylate kinase, active site lid domain

Adenylate_kinase_lid-dom

2

IPR007863

7,863

Peptidase M16, C-terminal

Peptidase_M16_C

Domain

109,199

false

These metallopeptidases belong to MEROPS peptidase family M16 (clan ME). They include proteins, which are classified as non-peptidase homologues either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity. The peptidase...

[]

0

[ "PFAM" ]

[ "PF05193" ]

[ "Peptidase_M16_C" ]

[ 109199 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.4.24", "GenProp1637", "R-BTA-5689880", "R-BTA-611105", "R-BTA-77387", "R-BTA-8949664", "R-BTA-9033241", "R-BTA-9837999", "R-BTA-9865881", "R-CEL-611105", "R-CEL-8949664", "R-CEL-9837999", "R-CEL-9865881", "R-DDI-611105", "R-DDI-9033241", "R-DDI-9837999", "R-DME-1268020", "R-DME-...

[ "EC:3.4.24", "GP:GenProp1637", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-8949664", "REACTOME:R-BTA-9033241", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9865881", "REACTOME:R-CEL-611105", "REACTOME:R-CEL-8949664", "REACTOME:R-CEL-9837999", "REAC...

54

[ "1bcc", "1be3", "1bgy", "1ezv", "1hr6", "1hr7", "1hr8", "1hr9", "1kb9", "1kyo", "1l0l", "1l0n", "1ntk", "1ntm", "1ntz", "1nu1", "1p84", "1pp9", "1ppj", "1q2l", "1qcr", "1sqb", "1sqp", "1sqq", "1sqv", "1sqx", "2a06", "2bcc", "2fge", "2fyu", "2g47", "2g48"...

299

[ "PUB00004194", "PUB00010202" ]

[ "7990931", "11470436" ]

[ "A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.", "Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences." ]

[ 1994, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 41, 68478, 39453, 53, 1174 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 56, 16, 17, 10, 3, 60, 24, 6, 39, 37, 6, 6, 140 ]

13

true

Domain

Peptidase M16, C-terminal

Peptidase_M16_C

1

IPR007865

7,865

Aminopeptidase P, N-terminal

Aminopep_P_N

Domain

26,160

false

This entry represents the N-terminal domain of aminopeptidase P (X-Pro aminopeptidase I,II and III ) and related sequences belonging to the peptidase M24B family. The domain is structurally very similar [ ] to the creatinase N-terminal domain ( ).

[ "GO:0030145", "GO:0070006" ]

[ "manganese ion binding", "metalloaminopeptidase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART" ]

[ "PF05195", "SM01011" ]

[ "AMP_N", "AMP_N" ]

[ 26135, 25849 ]

2

[ "EC" ]

[ "3.4.11.9" ]

[ "EC:3.4.11.9" ]

1

[ "1a16", "1jaw", "1m35", "1n51", "1w2m", "1w7v", "1wbq", "1wl6", "1wl9", "1wlr", "2bh3", "2bha", "2bhb", "2bhc", "2bhd", "2bn7", "2bws", "2bwt", "2bwu", "2bwv", "2bww", "2bwx", "2bwy", "2iw2", "2okn", "2v3x", "2v3y", "2v3z", "3ig4", "4pv4", "5m4g", "5m4j"...

54

[ "PUB00010137" ]

[ "9520390" ]

[ "Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Klosneuvirinae", "Methanobacteriati", "unclassified sequences" ]

[ 15295, 10556, 2, 8, 299 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 3, 3, 4, 1, 16, 3, 4, 5, 9, 2, 1, 19 ]

13

true

Domain

Aminopeptidase P, N-terminal

Aminopep_P_N

1

IPR007866

7,866

TRIC channel

TRIC_channel

Family

2,921

false

TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalen...

[ "GO:0005267", "GO:0042802", "GO:0071805", "GO:0016020" ]

[ "potassium channel activity", "identical protein binding", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05197", "PTHR12454" ]

[ "TRIC", "" ]

[ 2910, 2805 ]

2

[]

0

[ "5egi", "5eik", "6iyu", "6iyx", "6iyz", "6iz0", "6iz1", "6iz3", "6iz4", "6iz5", "6iz6", "6izf" ]

12

[ "PUB00053854" ]

[ "17611541" ]

[ "TRIC channels are essential for Ca2+ handling in intracellular stores." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Pantoea vagans" ]

[ 2920, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 6, 7, 5, 10 ]

6

true

Family

TRIC channel

TRIC_channel

5

IPR007867

7,867

Glucose-methanol-choline oxidoreductase, C-terminal

GMC_OxRtase_C

Domain

114,629

false

The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases [ , ]. These enzymes include a variety of proteins; choline dehydrogenase (CHD), methanol oxidase (MOX) and cellobiose dehydrogenase ( ) [ ] which share a number of regions of sequence similarities. The function of this C-terminal ...

[ "GO:0016614" ]

[ "oxidoreductase activity, acting on CH-OH group of donors" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05199" ]

[ "GMC_oxred_C" ]

[ 114629 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798163", "R-MMU-6798163", "R-RNO-6798163" ]

[ "REACTOME:R-HSA-6798163", "REACTOME:R-MMU-6798163", "REACTOME:R-RNO-6798163" ]

3

[ "1b4v", "1b8s", "1cbo", "1cc2", "1cf3", "1coy", "1gal", "1gpe", "1ijh", "1ju2", "1kdg", "1mxt", "1n1p", "1n4u", "1n4v", "1n4w", "1naa", "1tt0", "1tzl", "2f5v", "2f6c", "2gew", "2igk", "2igm", "2ign", "2igo", "2jbv", "3b3r", "3b6d", "3bg6", "3bg7", "3bly"...

189

[ "PUB00000376", "PUB00003282", "PUB00006692" ]

[ "8218217", "1542121", "10725534" ]

[ "Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases.", "GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.", "A critical review of cellobiose dehydrogenases." ]

[ 1993, 1992, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 587, 57670, 55432, 1, 105, 834 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 73, 1, 1, 43, 1, 2, 3, 10, 40, 3, 49 ]

11

true

Domain

Glucose-methanol-choline oxidoreductase, C-terminal

GMC_OxRtase_C

1

IPR007868

7,868

Hom-end-associated Hint

Hom_end_hint

Domain

975

false

Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [ ] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a second dom...

[ "GO:0030908" ]

[ "protein splicing" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05203" ]

[ "Hom_end_hint" ]

[ 975 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-1222556", "R-SCE-77387", "R-SCE-917977", "R-SCE-9639288" ]

[ "REACTOME:R-SCE-1222556", "REACTOME:R-SCE-77387", "REACTOME:R-SCE-917977", "REACTOME:R-SCE-9639288" ]

4

[ "1dfa", "1ef0", "1gpp", "1jva", "1lws", "1lwt", "1um2", "1vde", "6mwy", "6mx6", "6myl", "6owu", "9cop" ]

13

[ "PUB00010172" ]

[ "12219083" ]

[ "Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 197, 559, 96, 123 ]

4

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Domain

Hom-end-associated Hint

Hom_end_hint

3

IPR007869

7,869

Homing endonuclease PI-Sce

Homing_endonuc_PI-Sce

Domain

718

false

Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [ ] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a second dom...

[ "GO:0003677", "GO:0004519", "GO:0030908" ]

[ "DNA binding", "endonuclease activity", "protein splicing" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05204" ]

[ "Hom_end" ]

[ 718 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-1222556", "R-SCE-77387", "R-SCE-917977", "R-SCE-9639288" ]

[ "REACTOME:R-SCE-1222556", "REACTOME:R-SCE-77387", "REACTOME:R-SCE-917977", "REACTOME:R-SCE-9639288" ]

4

[ "1dfa", "1ef0", "1jva", "1lws", "1lwt", "1um2", "1vde", "9cop" ]

8

[ "PUB00010172" ]

[ "12219083" ]

[ "Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrososphaera gargensis (strain Ga9.2)", "Viruses", "metagenomes" ]

[ 114, 439, 1, 76, 88 ]

5

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Domain

Homing endonuclease PI-Sce

Homing_endonuc_PI-Sce

1

IPR007871

7,871

Methyltransferase TRM13

Methyltransferase_TRM13

Domain

3,263

false

This entry consists of eukaryotic and bacterial proteins that specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signatures [ ]. The alignment contains some conserved cysteines and histidines that might form a zinc binding site.

[ "GO:0008168", "GO:0008033" ]

[ "methyltransferase activity", "tRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05206" ]

[ "TRM13" ]

[ 3263 ]

1

[ "EC", "METACYC", "REACTOME" ]

[ "2.1.1.225", "PWY-6829", "R-HSA-6782315" ]

[ "EC:2.1.1.225", "METACYC:PWY-6829", "REACTOME:R-HSA-6782315" ]

3

[]

0

[ "PUB00045160" ]

[ "17242307" ]

[ "The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Klosneuvirinae" ]

[ 3260, 3 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 7, 1, 1, 1, 2, 4, 2, 2, 1, 1, 7 ]

11

true

Domain

Methyltransferase TRM13

Methyltransferase_TRM13

2

IPR007872

7,872

DPH-type metal-binding domain

DPH_MB_dom

Domain

7,716

false

This entry represents the DPH-type metal binding domain consists of a three-stranded β-sandwich with one sheet comprising two parallel strands: (i) β1 and (ii) β6 and one antiparallel strand: β5. The second sheet in the β-sandwich is comprised of strands β2, β3, and β4 running anti-parallel to each other. The two β-she...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05207", "PS51074" ]

[ "Zn_ribbon_CSL", "DPH_MB" ]

[ 7599, 7590 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51074", "R-BTA-5358493", "R-CEL-5358493", "R-DME-5358493", "R-HSA-5358493", "R-MMU-5358493", "R-SCE-5358493", "R-SPO-5358493" ]

[ "PROSITEDOC:PDOC51074", "REACTOME:R-BTA-5358493", "REACTOME:R-CEL-5358493", "REACTOME:R-DME-5358493", "REACTOME:R-HSA-5358493", "REACTOME:R-MMU-5358493", "REACTOME:R-SCE-5358493", "REACTOME:R-SPO-5358493" ]

8

[ "1wge", "1yop", "1yws", "2jr7", "2l6l", "4d4o", "4d4p", "4x33", "5ax2" ]

9

[ "PUB00017069", "PUB00017070", "PUB00017080", "PUB00021079", "PUB00046549", "PUB00093536", "PUB00093772" ]

[ "14527407", "15485916", "11595641", "15952786", "18021800", "22367199", "25543256" ]

[ "Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins.", "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.", ...

[ 2003, 2004, 2001, 2005, 2008, 2012, 2015 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 42, 7673, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 51, 3, 3, 5, 2, 6, 4, 2, 2, 11 ]

12

true

Domain

DPH-type metal-binding domain

DPH_MB_dom

9

IPR007873

7,873

Glycosyltransferase, ALG3

Glycosyltransferase_ALG3

Family

4,870

false

The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions fr...

[ "GO:0000030" ]

[ "mannosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05208", "PTHR12646" ]

[ "ALG3", "" ]

[ 4870, 4746 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.258", "R-DDI-446193", "R-DME-446193", "R-HSA-446193", "R-HSA-4720475", "R-MMU-446193", "R-SCE-446193", "R-SPO-446193" ]

[ "EC:2.4.1.258", "REACTOME:R-DDI-446193", "REACTOME:R-DME-446193", "REACTOME:R-HSA-446193", "REACTOME:R-HSA-4720475", "REACTOME:R-MMU-446193", "REACTOME:R-SCE-446193", "REACTOME:R-SPO-446193" ]

8

[]

0

[ "PUB00010136" ]

[ "11308030" ]

[ "Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)", "freshwater metagenome" ]

[ 32, 4833, 1, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 5, 3, 5, 9, 1, 4, 5, 1, 1, 6 ]

12

true

Family

Glycosyltransferase, ALG3

Glycosyltransferase_ALG3

1

IPR007874

7,874

Septum formation inhibitor MinC, N-terminal

MinC_N

Domain

6,776

false

In Escherichia coli FtsZ ( ) assembles into a Z ring at midcell. Its assembly at polar sites is prevented by the min system. MinC , a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with the MinDE proteins. MinC is an oligomer, probably a dimer [ ]. The C-ter...

[ "GO:0051302" ]

[ "regulation of cell division" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05209" ]

[ "MinC_N" ]

[ 6776 ]

1

[]

0

[ "1hf2", "3ghf", "4l1c" ]

3

[ "PUB00008426" ]

[ "10869074" ]

[ "Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6717, 12, 47 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Septum formation inhibitor MinC, N-terminal

MinC_N

6

IPR007875

7,875

Sprouty

Family

6,829

false

Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [ , ]. These proteins share a conserved, C-terminal cy...

[ "GO:0007275", "GO:0009966", "GO:0016020" ]

[ "multicellular organism development", "regulation of signal transduction", "membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PROFILE" ]

[ "PF05210", "PS51227" ]

[ "Sprouty", "SPR" ]

[ 6829, 6679 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51227", "R-BTA-1295596", "R-BTA-182971", "R-DME-1295596", "R-DME-182971", "R-DRE-5658623", "R-HSA-1295596", "R-HSA-182971", "R-HSA-5658442", "R-HSA-5658623", "R-HSA-6802953", "R-MMU-1295596", "R-MMU-182971", "R-MMU-5658442", "R-MMU-5658623", "R-RNO-5658442", "R-RNO-5658623", "...

[ "PROSITEDOC:PDOC51227", "REACTOME:R-BTA-1295596", "REACTOME:R-BTA-182971", "REACTOME:R-DME-1295596", "REACTOME:R-DME-182971", "REACTOME:R-DRE-5658623", "REACTOME:R-HSA-1295596", "REACTOME:R-HSA-182971", "REACTOME:R-HSA-5658442", "REACTOME:R-HSA-5658623", "REACTOME:R-HSA-6802953", "REACTOME:R-M...

18

[]

0

[ "PUB00010235", "PUB00035330", "PUB00035331", "PUB00035332", "PUB00035333" ]

[ "12391162", "15683364", "10887178", "11493923", "12402043" ]

[ "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.", "Distinct requirements for the Sprouty domain for functional activity of Spred proteins.", "Sprouty proteins are targeted to membrane ruffl...

[ 2002, 2005, 2000, 2001, 2002 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 6829 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 5, 14, 13, 24 ]

5

true

Family

Sprouty

6

IPR007876

7,876

Neuraminyllactose-binding hemagglutinin

NeuraminylLac-bd_hemagglutn

Family

351

false

This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding haemagglutinin precursor (NLBH or HpaA) or N-acetylneuraminyllactose-binding fibrillar haemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bin...

[ "GO:0009279" ]

[ "cell outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05211", "PIRSF019714" ]

[ "NLBH", "Neuraminyllac-bd_haemagglutn" ]

[ 351, 315 ]

2

[]

0

[ "2i9i", "3bgh", "8t8d" ]

3

[ "PUB00010192", "PUB00033190" ]

[ "11855744", "7592366" ]

[ "Inhibition of Helicobacter pylori adherence by a peptide derived from neuraminyl lactose binding adhesin.", "The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein." ]

[ 2001, 1995 ]

2

[]

0

null

[ "Bacteria" ]

[ 351 ]

1

[]

0

true

Family

Neuraminyllactose-binding hemagglutinin

NeuraminylLac-bd_hemagglutn

6

IPR007877

7,877

Protein of unknown function DUF707

DUF707

Family

7,477

false

This family consists of uncharacterised proteins from Arabidopsis thaliana.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05212", "PTHR31210" ]

[ "DUF707", "" ]

[ 7466, 6993 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "Megaviridae environmental sample", "viral metagenome" ]

[ 149, 1, 7323, 1, 3 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 86, 37, 100 ]

3

true

Family

Protein of unknown function DUF707

DUF707

4

IPR007878

7,878

Coronavirus NS2A

Coronavirus_NS2A

Family

125

false

This entry is represented by Coronavirus non-structural protein 2A (32kDa); it is a family of uncharacterised viral proteins. Members have a phosphoesterase module (2H) [ ] and are predicted to be involved in RNA modification. The viral group of 2H phosphoesterases contains proteins from two unrelated virus types: the ...

[]

0

[ "PIRSF" ]

[ "PIRSF003890" ]

[ "LigT_coronavirus" ]

[ 125 ]

1

[]

0

[]

0

[ "PUB00013642" ]

[ "12466548" ]

[ "Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily." ]

[ 2002 ]

1

[]

0

null

[ "Embecovirus" ]

[ 125 ]

1

[]

0

true

Family

Coronavirus NS2A

Coronavirus_NS2A

4

IPR007879

7,879

FAD-linked sulfhydryl oxidase

Baculo_p33

Family

153

false

This family consists of a series of baculoviral 33kDa early protein homologues. Autographa californica nuclear polyhedrosis virus (AcMNPV) p33 has been shown to be a functional FAD-linked sulfhydryl oxidase [ ].

[]

0

[ "PFAM" ]

[ "PF05214" ]

[ "Baculo_p33" ]

[ 153 ]

1

[]

0

[ "3p0k", "3qzy", "3ust", "5xki", "5xtn", "5xto", "5xtp", "5xtq", "5xtr" ]

9

[ "PUB00082585" ]

[ "19409596" ]

[ "The conserved baculovirus protein p33 (Ac92) is a flavin adenine dinucleotide-linked sulfhydryl oxidase." ]

[ 2009 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 153 ]

1

[]

0

true

Family

FAD-linked sulfhydryl oxidase

Baculo_p33

4

IPR007880

7,880

Spiralin, C-terminal domain

Spiralin_C

Domain

290

false

This entry represents the C-terminal domain of Spiralin from Spiroplasma citri and similar proteins from Tenericutes. The surface of spiroplasma bacteria is crowded with the membrane-anchored lipoprotein spiralin, whose structure and function are unknown, although its cellular function is thought to be a structural and...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05215" ]

[ "Spiralin" ]

[ 290 ]

1

[]

0

[]

0

[ "PUB00010230" ]

[ "11988221" ]

[ "Secondary structure of spiralin in solution, at the air/water interface, and in interaction with lipid monolayers." ]

[ 2002 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 290 ]

1

[]

0

true

Domain

Spiralin, C-terminal domain

Spiralin_C

8

IPR007881

7,881

UNC-50

Family

3,986

false

This family contains several eukaryotic transmembrane proteins which are related to the Caenorhabditis elegans protein UNC-50 . A mammalian homologue, UNCL is a novel inner nuclear membrane protein that associates with RNA and is involved in the cell-surface expression of neuronal nicotinic receptors. UNCL plays a broa...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05216", "PTHR12841" ]

[ "UNC-50", "" ]

[ 3985, 3886 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Schaedlerella arabinosiphila" ]

[ 3985, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 7, 1, 2, 1, 6, 4, 2, 2, 1, 1, 13 ]

11

true

Family

UNC-50

8

IPR007882

7,882

Microtubule-associated protein 6

MAP6

Family

1,583

false

Microtubule-associated protein 6 (MAP6) is a calmodulin binding protein that is involved in microtubule stabilisation [ ]. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal deve...

[ "GO:0005516", "GO:0008017", "GO:0000226", "GO:0005874" ]

[ "calmodulin binding", "microtubule binding", "microtubule cytoskeleton organization", "microtubule" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PANTHER" ]

[ "PTHR14759" ]

[ "" ]

[ 1583 ]

1

[]

0

[]

0

[ "PUB00010224", "PUB00063868", "PUB00070924", "PUB00095380" ]

[ "12231625", "16806091", "24357581", "28521134" ]

[ "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.", "Microtubule stabilizer ameliorates synaptic function and behavior in a mouse model for schizophrenia.", "The FTLD risk factor TMEM106B and MAP6 control dendritic tra...

[ 2002, 2006, 2014, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1583 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 4, 4, 8 ]

4

true

Family

Microtubule-associated protein 6

MAP6

3

IPR007883

7,883

Protein of unknown function DUF713

DUF713

Family

262

false

This family contains proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05218", "PTHR21566" ]

[ "DUF713", "" ]

[ 217, 243 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditina", "Thermus brockianus" ]

[ 261, 1 ]

2

[ "Caenorhabditis elegans" ]

[ 21 ]

1

true

Family

Protein of unknown function DUF713

DUF713

1

IPR007884

7,884

Protein-L-histidine N-pros-methyltransferase

METL9

Family

2,131

false

This family contains protein-histidine N-methyltransferases (also known as DORA reverse strand protein DREV) that specifically catalyse 1-methylhistidine (pros-methylhistidine) methylation of target proteins, such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12 [ , ]. They mediate methylation of proteins with a ...

[ "GO:0106370" ]

[ "protein-L-histidine N-pros-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05219", "PTHR12890" ]

[ "DREV", "" ]

[ 2127, 2083 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[ "7y9c", "7yf2", "7yf3", "7yf4", "8bvi", "8gze", "8gzf" ]

7

[ "PUB00010151", "PUB00097903" ]

[ "11132146", "33563959" ]

[ "The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function.", "The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes." ]

[ 2000, 2021 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2129, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 7, 3, 7 ]

6

true

Family

Protein-L-histidine N-pros-methyltransferase

METL9

5

IPR007885

7,885

MgpC adhesin

MgpC

Family

259

false

This family contains several Mycoplasma MgpC-like proteins. MgpC encode antigenic proteins associated with attachment [ ]. The structure of MGP3 shows that this entry is a partial match to a large β propeller domain that binds to sialic acid [ ].

[]

0

[ "PFAM" ]

[ "PF05220" ]

[ "MgpC" ]

[ 259 ]

1

[]

0

[ "5ox7", "6r3t", "6r41", "6r43", "6rj1", "6rut", "6se5", "6se7", "6tlz", "6tm0", "6yrk", "8pbx", "8pby", "8pbz", "8pc0", "8pc1" ]

16

[ "PUB00053856", "PUB00098629" ]

[ "17880423", "30367053" ]

[ "mgpB and mgpC sequence diversity in Mycoplasma genitalium is generated by segmental reciprocal recombination with repetitive chromosomal sequences.", "Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors." ]

[ 2007, 2018 ]

2

[]

0

null

[ "Mycoplasmoides" ]

[ 259 ]

1

[]

0

true

Family

MgpC adhesin

MgpC

6

IPR007886

7,886

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal

AlaDH/PNT_N

Domain

45,238

false

Alanine dehydrogenase catalyses the NAD-dependent reversible reductive amination of pyruvate into alanine. Pyridine nucleotide transhydrogenase catalyses the reduction of NADP + to NADPH with the concomitant oxidation of NADH to NAD + . This enzyme is located in the plasma membrane of prokaryotes and in the inner membr...

[]

0

[ "PFAM", "SMART" ]

[ "PF05222", "SM01003" ]

[ "AlaDh_PNT_N", "AlaDh_PNT_N" ]

[ 45144, 44901 ]

2

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1487", "R-BTA-71064", "R-BTA-71403", "R-HSA-71064", "R-HSA-71403", "R-MMU-71064", "R-MMU-71403", "R-RNO-71064" ]

[ "GP:GenProp1487", "REACTOME:R-BTA-71064", "REACTOME:R-BTA-71403", "REACTOME:R-HSA-71064", "REACTOME:R-HSA-71403", "REACTOME:R-MMU-71064", "REACTOME:R-MMU-71403", "REACTOME:R-RNO-71064" ]

8

[ "1f8g", "1hzz", "1l7d", "1l7e", "1nm5", "1pjb", "1pjc", "1ptj", "1say", "1u28", "1u2d", "1u2g", "1x13", "1x14", "1x15", "1xlt", "2bru", "2eez", "2fr8", "2frd", "2fsv", "2oo5", "2oor", "2q99", "2qrj", "2qrk", "2qrl", "2vhv", "2vhw", "2vhx", "2vhy", "2vhz"...

55

[ "PUB00000218", "PUB00019119" ]

[ "8439307", "11354603" ]

[ "Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis.", "Lysine metabolism in higher plants." ]

[ 1993, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 83, 34780, 9554, 7, 814 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 3, 37, 2, 1, 17, 13, 2, 2, 13, 1, 1, 15 ]

13

true

Domain

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal

AlaDH/PNT_N

1

IPR007887

7,887

Penicillin-binding protein 3-like, N-terminal domain

MecA_N

Domain

7,380

false

The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. Methicillin resistance in MRSA strains is due to the acquisition of the mecA gene via horizontal transfer from an unidentified species which encodes penicillin-binding prote...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05223" ]

[ "MecA_N" ]

[ 7380 ]

1

[]

0

[ "1mwr", "1mws", "1mwt", "1mwu", "1vqq", "3zfz", "3zg0", "3zg5", "4bl2", "4bl3", "4cjn", "4cpk", "4dki", "5dvy", "5e31", "5m18", "5m19", "5m1a", "6bsq", "6bsr", "6c84", "6g0k", "6g88", "6h5o", "6mka", "6mkf", "6mkg", "6mkh", "6mki", "6mkj", "6q9n", "7bn9"...

54

[ "PUB00010424", "PUB00163286", "PUB00163287" ]

[ "12389036", "28792086", "35659317" ]

[ "Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.", "Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis.", "Transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding prote...

[ 2002, 2017, 2022 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 7352, 3, 5, 20 ]

4

[]

0

true

Domain

Penicillin-binding protein 3-like, N-terminal domain

MecA_N

7

IPR007889

7,889

DNA binding HTH domain, Psq-type

HTH_Psq

Domain

24,939

false

The psq-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50 amino acids present in eukaryotic proteins of the Pipsqueak family. This family is named after the Drosophila pipsqueak protein, containing a DNA-binding domain that consists of four tandem repeats of the psq motif [ ]. Proteins of the ...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PFAM", "PROFILE" ]

[ "PF04218", "PF05225", "PS50960" ]

[ "CENP-B_N", "HTH_psq", "HTH_PSQ" ]

[ 10135, 14267, 10133 ]

3

[]

0

[ "1bw6", "1hlv", "2cob", "2elh" ]

4

[ "PUB00010427", "PUB00014772", "PUB00025705" ]

[ "9774480", "11976954", "11726497" ]

[ "The pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain.", "The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins.", "Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks ...

[ 1998, 2002, 2001 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 14, 1014, 23857, 36, 18 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 8, 50, 31, 15, 2, 19 ]

7

true

Domain

DNA binding HTH domain, Psq-type

HTH_Psq

6

IPR007890

7,890

CHASE2

Domain

10,408

false

CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are upstream of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodie...

[]

0

[ "PFAM", "SMART" ]

[ "PF05226", "SM01080" ]

[ "CHASE2", "CHASE2" ]

[ 10364, 9985 ]

2

[]

0

[]

0

[ "PUB00010429" ]

[ "12486065" ]

[ "Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 10126, 3, 14, 13, 252 ]

5

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

CHASE2

2

IPR007891

7,891

CHASE3

Domain

14,721

false

CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are upstream of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclase...

[]

0

[ "PFAM" ]

[ "PF05227" ]

[ "CHASE3" ]

[ 14721 ]

1

[]

0

[ "3va9" ]

1

[ "PUB00010429" ]

[ "12486065" ]

[ "Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sylvanvirus sp.", "unclassified sequences" ]

[ 4, 14679, 4, 1, 33 ]

5

[]

0

true

Domain

CHASE3

1

IPR007892

7,892

CHASE4

Domain

4,553

false

CHASE4 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are upstream of signal transduction pathways in prokaryotes. Specifically, CHASE4 domains are found in histidine kinases in archaea and in predicted diguanylate cyclases/phosphodiesterases in bacteria. Environ...

[]

0

[ "PFAM" ]

[ "PF05228" ]

[ "CHASE4" ]

[ 4553 ]

1

[]

0

[ "8wct", "8z5k", "8z6n", "8z84" ]

4

[ "PUB00010429" ]

[ "12486065" ]

[ "Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 207, 4297, 28, 21 ]

4

[]

0

true

Domain

CHASE4

3

IPR007893

7,893

Spore coat protein U/FanG

Spore_coat_U/FanG

Domain

7,522

false

This domain is found in protein U, a spore coat protein produced at the late stage of development of Myxococcus xanthus. Protein U is produced as a secretory precursor, pro-protein U, which is then secreted across the membrane to assemble on the spore surface [ ]. This domain is also found in a number of the genes with...

[]

0

[ "PFAM" ]

[ "PF05229" ]

[ "SCPU" ]

[ 7522 ]

1

[]

0

[ "5d6h", "6fjy", "6fm5", "6fq0", "6fqa", "7zl4", "8cio" ]

7

[ "PUB00010430", "PUB00015046", "PUB00154350" ]

[ "1904442", "14663080", "1687753" ]

[ "Protein U, a late-developmental spore coat protein of Myxococcus xanthus, is a secretory protein.", "Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system.", "Localization and function of FanH and FanG, minor components o...

[ 1991, 2003, 1991 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7474, 20, 28 ]

3

[]

0

true

Domain

Spore coat protein U/FanG

Spore_coat_U/FanG

7

IPR007895

7,895

MASE1

Domain

13,008

false

This domain has been reported to bind aspartate [ ] and participate in protein-protein interactions [ ].

[]

0

[ "PFAM" ]

[ "PF05231" ]

[ "MASE1" ]

[ 13008 ]

1

[]

0

[]

0

[ "PUB00100646", "PUB00100647" ]

[ "23740576", "31022167" ]

[ "Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate.", "Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system." ]

[ 2013, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Ectocarpus siliculosus virus 1 (isolate New Zealand/Kaikoura/1988)", "Eukaryota", "unclassified sequences" ]

[ 8, 12845, 1, 87, 67 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

MASE1

9

IPR007896

7,896

Chlorhexidine efflux transporter

BTP_bacteria

Domain

5,473

false

This entry represents a conserved pair of two transmembrane α-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and...

[]

0

[ "PFAM" ]

[ "PF05232" ]

[ "BTP" ]

[ 5473 ]

1

[]

0

[]

0

[ "PUB00075703" ]

[ "24277845" ]

[ "Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5444, 7, 22 ]

3

[]

0

true

Domain

Chlorhexidine efflux transporter

BTP_bacteria

9

IPR007897

7,897

PHB accumulation regulatory

PHB_accumulat

Domain

4,572

false

The proteins this domain is found in are typically involved in regulating polymer accumulation in bacteria, for example the production of poly-beta-hydroxybutyrate (PHB) which is formed via the polymerisation of D(-)-3-hydroxybutyryl-CoA [ ]. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF05233" ]

[ "PHB_acc" ]

[ 4572 ]

1

[]

0

[]

0

[ "PUB00010431" ]

[ "9922249" ]

[ "PhaF, a polyhydroxyalkanoate-granule-associated protein of Pseudomonas oleovorans GPo1 involved in the regulatory expression system for pha genes." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4531, 4, 37 ]

3

[]

0

true

Domain

PHB accumulation regulatory

PHB_accumulat

8

IPR007898

7,898

RNA polymerase I-specific transcription initiation factor Rrn10, Saccharomycetes

Rrn10_Saccharomycetes

Family

32

false

The protein Rrn10 has been identified as a component of the Upstream Activating Factor (UAF), an RNA polymerase I (pol I) specific transcription stimulatory factor that recognises the upstream ribosomal RNA (rRNA) gene promoter in a sequence specific manner and which stimulates rRNA synthesis [ ]. This entry represents...

[ "GO:0001165", "GO:0042790", "GO:0000500" ]

[ "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "nucleolar large rRNA transcription by RNA polymerase I", "RNA polymerase I upstream activating factor complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF009867" ]

[ "UAF_Rrn10" ]

[ 32 ]

1

[]

0

[ "7z0o" ]

1

[ "PUB00010432" ]

[ "12490702" ]

[ "Characterization of the fission yeast ribosomal DNA binding factor: components share homology with Upstream Activating Factor and with SWI/SNF subunits." ]

[ 2002 ]

1

[ "IPR022793" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 32 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

RNA polymerase I-specific transcription initiation factor Rrn10, Saccharomycetes

Rrn10_Saccharomycetes

4

IPR007899

7,899

CHAD domain

CHAD_dom

Domain

14,203

false

The CHAD (conserved histidine α-helical) domain has been identified as a specific binding module for inorganic polyphosphates (polyPs), linear polymers of orthophosphate units linked by phosphoanhydride bonds. This binding has been observed in bacterial, archaeal, and eukaryotic CHAD domains, which are formed by two fo...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05235", "PS51708", "SM00880" ]

[ "CHAD", "CHAD", "CHAD" ]

[ 14028, 13571, 11804 ]

3

[]

0

[ "3e0s", "5a60", "5a61", "6qv5", "6qv7", "6qva", "6rn5" ]

7

[ "PUB00010433", "PUB00151087" ]

[ "12456267", "31133615" ]

[ "The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates.", "Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules." ]

[ 2002, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 105, 13945, 19, 134 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

CHAD domain

CHAD_dom

6

IPR007900

7,900

Transcription initiation factor TFIID component TAF4, C-terminal

TAF4_C

Domain

7,364

false

Accurate transcription initiation at protein-coding genes by RNA polymerase II requires the assembly of a multiprotein complex around the mRNA start site. Transcription factor TFIID is one of the general factors involved in this process. Yeast TFIID comprises the TATA binding protein and 14 TBP-associated factors (TAFI...

[ "GO:0006352", "GO:0005669" ]

[ "DNA-templated transcription initiation", "transcription factor TFIID complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF05236", "cd08045" ]

[ "TAF4", "HFD_TAF4" ]

[ 7347, 5826 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp2054", "GenProp2057", "R-CEL-674695", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6804756", ...

[ "GP:GenProp2054", "GP:GenProp2057", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-...

33

[ "1h3o", "6hqa", "6mzc", "6mzd", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq", "8war", "8was" ]

31

[ "PUB00010434", "PUB00028598", "PUB00079563", "PUB00098146" ]

[ "12237303", "12237304", "19635797", "30442764" ]

[ "Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain.", "Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).", "TAF4/4b x T...

[ 2002, 2002, 2009, 2018 ]

4

[]

0

null

[ "Eukaryota" ]

[ 7364 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 1, 10, 8, 9, 7, 1, 9, 8, 1, 1, 28 ]

12

true

Domain

Transcription initiation factor TFIID component TAF4, C-terminal

TAF4_C

6

IPR007902

7,902

Centromere protein Chl4/mis15/CENP-N

Chl4/mis15/CENP-N

Family

2,384

false

This family includes Chl4 from budding yeasts, mis15 from fission yeasts and centromere protein N (CENP-N) from animals. In Saccharomyces cerevisiae, Chl4 is an outer kinetochore structural component required for chromosome stability [ ]. Chl4 is a component of the Ctf19 kinetochore complex that interacts with Ctf19p, ...

[ "GO:0007059", "GO:0034080" ]

[ "chromosome segregation", "CENP-A containing chromatin assembly" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF05238" ]

[ "CENP-N" ]

[ 2384 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-5663220", "R-GGA-606279", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", ...

[ "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-5663220", "REACTOME:R-GGA-606279", "REACTOME:R-GGA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-606279", "REACTOME:R-...

34

[ "4je3", "6buz", "6c0w", "6eqt", "6muo", "6mup", "6nuw", "6qld", "6qle", "6qlf", "7bxt", "7pkn", "7qoo", "7r5s", "7r5v", "7u46", "7u47", "7u4d", "7xhn", "7xho", "7ywx", "7yyh", "8ovw", "8ow0", "8ow1" ]

25

[ "PUB00044194", "PUB00044930", "PUB00066486", "PUB00066487", "PUB00066488", "PUB00066973", "PUB00066974" ]

[ "16622419", "12589047", "16716197", "19543270", "9339342", "16855021", "21445296" ]

[ "The human CENP-A centromeric nucleosome-associated complex.", "Chl4p and iml3p are two new members of the budding yeast outer kinetochore.", "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.", "Centromere assembly requires the dire...

[ 2006, 2003, 2006, 2009, 1997, 2006, 2011 ]

7

[]

0

null

[ "Eukaryota" ]

[ 2384 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 4, 2, 1, 6, 1, 1 ]

7

true

Family

Centromere protein Chl4/mis15/CENP-N

Chl4/mis15/CENP-N

3

IPR007905

7,905

Emopamil-binding protein

EBP

Family

5,339

false

Emopamil binding protein (EBP) is a nonglycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activi...

[ "GO:0047750", "GO:0016125", "GO:0016020" ]

[ "cholestenol delta-isomerase activity", "sterol metabolic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR14207" ]

[ "" ]

[ 5339 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.3", "R-DDI-6807047", "R-DDI-6807062", "R-HSA-6807047", "R-HSA-6807062", "R-MMU-6807047", "R-MMU-6807062", "R-RNO-6807047", "R-RNO-6807062" ]

[ "EC:5.3.3", "REACTOME:R-DDI-6807047", "REACTOME:R-DDI-6807062", "REACTOME:R-HSA-6807047", "REACTOME:R-HSA-6807062", "REACTOME:R-MMU-6807047", "REACTOME:R-MMU-6807062", "REACTOME:R-RNO-6807047", "REACTOME:R-RNO-6807062" ]

9

[ "6oht", "6ohu", "8w0r", "8w0s" ]

4

[ "PUB00010438" ]

[ "11471053" ]

[ "Mouse Tdho abnormality results from double point mutations of the emopamil binding protein gene (Ebp)." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "bird metagenome" ]

[ 52, 5286, 1 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 2, 7, 3, 2, 3, 5, 12 ]

8

true

Family

Emopamil-binding protein

EBP

7

IPR007908

7,908

Outer membrane protein 2, Brucella

OMP2_Brucella

Family

20

false

This family consists of several outer membrane proteins (2a and 2b) from Brucella abortus. B. abortus is Gram-negative, facultative intracellular bacteria that can infect many species of animals and Homo sapiens [ ].

[]

0

[ "PFAM" ]

[ "PF05244" ]

[ "Brucella_OMP2" ]

[ 20 ]

1

[]

0

[]

0

[ "PUB00010440" ]

[ "9884218" ]

[ "Phenotypic and molecular characterization of a Brucella strain isolated from a minke whale (Balaenoptera acutorostrata)." ]

[ 1998 ]

1

[]

0

null

[ "Hyphomicrobiales" ]

[ 20 ]

1

[]

0

true

Family

Outer membrane protein 2, Brucella

OMP2_Brucella

6

IPR007910

7,910

Protein of unknown function DUF735

DUF735

Family

171

false

This family consists of several uncharacterised Borrelia burgdorferi proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF05246" ]

[ "DUF735" ]

[ 171 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 171 ]

1

[]

0

true

Family

Protein of unknown function DUF735

DUF735

2

IPR007912

7,912

Adenovirus E3A

Adeno_E3A

Family

210

false

Adenoviruses have evolved multiple mechanisms to evade the host immune response. Several of the immunomodulatory adenoviral proteins are encoded in early transcription unit 3 (E3). The E3A/19K protein interferes with antigen presentation and T cell recognition [ ].

[]

0

[ "PFAM" ]

[ "PF05248" ]

[ "Adeno_E3A" ]

[ 210 ]

1

[]

0

[]

0

[ "PUB00010442" ]

[ "9707602" ]

[ "The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization." ]

[ 1998 ]

1

[]

0

null

[ "Mastadenovirus" ]

[ 210 ]

1

[]

0

true

Family

Adenovirus E3A

Adeno_E3A

3

IPR007914

7,914

Uncharacterised protein family UPF0193

UPF0193

Family

1,804

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05250", "PTHR28348" ]

[ "UPF0193", "" ]

[ 1799, 1724 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1804 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4, 11, 6 ]

5

true

Family

Uncharacterised protein family UPF0193

UPF0193

3

IPR007918

7,918

Mitochondrial distribution/morphology family 35/apoptosis

MDM35_apoptosis

Family

3,490

false

This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM) [ ]; wherease in Homo sapiens (Human), p53CSV, is a direct transcriptional target for p53 an...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05254", "PTHR46403" ]

[ "UPF0203", "" ]

[ 3490, 3120 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6803204", "R-HSA-9837999", "R-MMU-6803204", "R-SCE-6803204", "R-SPO-6803204" ]

[ "REACTOME:R-HSA-6803204", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-6803204", "REACTOME:R-SCE-6803204", "REACTOME:R-SPO-6803204" ]

5

[ "4xhr", "4xiz", "4xzs", "4xzv", "4ytv", "4ytw", "4ytx", "5jql", "5jqm", "6i3v", "6i3y", "6i4y", "6kyl", "8ag0" ]

14

[ "PUB00033261", "PUB00033262" ]

[ "11907266", "15735003" ]

[ "Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.", "p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway." ]

[ 2002, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3490 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 2, 1, 1, 1, 3, 2, 1, 1, 3 ]

12

true

Family

Mitochondrial distribution/morphology family 35/apoptosis

MDM35_apoptosis

4

IPR007919

7,919

Uncharacterised protein family UPF0220

UPF0220

Family

5,316

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05255", "PTHR13180" ]

[ "UPF0220", "" ]

[ 5287, 5201 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5316 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 9, 3, 1, 10, 5, 1, 1, 11 ]

12

true

Family

Uncharacterised protein family UPF0220

UPF0220

5

IPR007920

7,920

Protein of unknown function UPF0223

UPF0223

Family

2,432

false

This family of proteins is functionally uncharacterised.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_01041", "NF003353", "PF05256", "PIRSF037260" ]

[ "UPF0223", "PRK04387.1", "UPF0223", "UPF0223" ]

[ 1410, 2299, 2432, 2215 ]

4

[]

0

[ "2oy9" ]

1

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2427, 1, 4 ]

3

[]

0

true

Family

Protein of unknown function UPF0223

UPF0223

2

IPR007921

7,921

CHAP domain

CHAP_dom

Domain

18,089

false

The CHAP (cysteine, histidine-dependent amidohydrolases/peptidases) domain is a region between 110 and 140 amino acids that is found in proteins from bacteria, bacteriophages, archaea and eukaryotes of the Trypanosomidae family. Many of these proteins are uncharacterised, but it has been proposed that they may function...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05257", "PS50911" ]

[ "CHAP", "CHAP" ]

[ 17739, 12891 ]

2

[ "PROSITEDOC" ]

[ "PDOC50911" ]

[ "PROSITEDOC:PDOC50911" ]

1

[ "2io7", "2io8", "2io9", "2ioa", "2iob", "2k3a", "2lrj", "2vob", "2vpm", "2vps", "3a2y", "3a2z", "3a30", "3o98", "4cgk", "4csh", "4ct3", "4f88", "4olk", "5d74", "5d76", "5t1q", "5udm", "5udn", "6ist", "8ej5", "8h1i", "8xyf", "9euf", "9eug", "9euh", "9eum"...

32

[ "PUB00011839", "PUB00011840" ]

[ "12765833", "12765834" ]

[ "Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases.", "The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinales", "Viruses", "metagenomes" ]

[ 15903, 1033, 3, 1059, 91 ]

5

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 1, 1 ]

2

true

Domain

CHAP domain

CHAP_dom

8

IPR007922

7,922

DciA-like

Family

16,645

false

This family include DciA from Pseudomonas aeruginosa ( ) and similar sequences mainly found in bacteria. DciA is a replicative helicase operator essential for bacterial replication initiation [ ].

[]

0

[ "PFAM" ]

[ "PF05258" ]

[ "DciA" ]

[ 16645 ]

1

[]

0

[ "7ykm", "8a3v" ]

2

[ "PUB00085163" ]

[ "27830752" ]

[ "DciA is an ancestral replicative helicase operator essential for bacterial replication initiation." ]

[ 2016 ]

1

[]

[ "IPR010593", "IPR016507", "IPR023007" ]

0

3

0

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "Streptomyces phage ZL12", "unclassified sequences" ]

[ 16234, 1, 14, 1, 395 ]

5

[]

0

true

Family

DciA-like

4

IPR007923

7,923

Herpesvirus glycoprotein L, N-terminal

Herpes_gL_N

Domain

224

false

Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. No single glycoprotein associated with the virion membrane has b...

[]

0

[ "PFAM" ]

[ "PF05259" ]

[ "Herpes_UL1" ]

[ 224 ]

1

[]

0

[ "3m1c", "4xhj", "4xi5" ]

3

[ "PUB00009448", "PUB00009449", "PUB00045942", "PUB00045943", "PUB00045944", "PUB00045945" ]

[ "9526546", "9267002", "17299053", "7769724", "3016991", "2552150" ]

[ "Identification and characterization of the guinea-pig cytomegalovirus glycoprotein H gene.", "Analysis of the biochemical properties of, and complex formation between, glycoproteins H and L of the gamma2 herpesvirus bovine herpesvirus-4.", "Herpes simplex virus type 1 mediates fusion through a hemifusion inter...

[ 1996, 1997, 2007, 1995, 1986, 1989 ]

6

[]

0

null

[ "Alphaherpesvirinae" ]

[ 224 ]

1

[]

0

true

Domain

Herpesvirus glycoprotein L, N-terminal

Herpes_gL_N

9

IPR007925

7,925

Relaxosome protein TraM

TRelaxosome_TraM

Family

856

false

TraM is a plasmid encoded DNA-binding protein that is essential for conjugative transfer of F-like plasmids (e.g. F, R1, R100 and pED208) between bacterial cells. Bacterial conjugation, a form of horizontal gene transfer between cells, is an important contributor to bacterial genetic diversity, enabling virulence and a...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PFAM", "CDD" ]

[ "NF010267", "PF05261", "cd14804" ]

[ "PRK13713.1", "Tra_M", "Tra_M" ]

[ 667, 856, 653 ]

3

[]

0

[ "1dp3", "2g7o", "2g9e", "3d8a", "3omy", "3on0", "4qpo", "4qpq" ]

8

[ "PUB00010445", "PUB00016452", "PUB00051289", "PUB00058835", "PUB00079457" ]

[ "11258958", "7915817", "18717787", "21565799", "22788760" ]

[ "Solution structure of the DNA-binding domain of TraM.", "Analysis of the sequence and gene products of the transfer region of the F sex factor.", "Structural basis of specific TraD-TraM recognition during F plasmid-mediated bacterial conjugation.", "Structural basis of cooperative DNA recognition by the plas...

[ 2001, 1994, 2008, 2011, 2012 ]

5

[]

0

null

[ "Bacteria", "Eumetazoa", "metagenomes" ]

[ 850, 4, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Relaxosome protein TraM

TRelaxosome_TraM

8

IPR007926

7,926

Borrelia P83100

Borrelia_P83

Family

324

false

This family consists of several Borrelia P83/P100 antigen proteins.

[]

0

[ "PFAM" ]

[ "PF05262" ]

[ "Borrelia_P83" ]

[ 324 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured Caudovirales phage" ]

[ 317, 6, 1 ]

3

[]

0

true

Family

Borrelia P83100

Borrelia_P83

3

IPR007928

7,928

Choristoneura fumiferana antifreeze

Antifreeze_CF

Family

50

false

Antifreeze proteins (AFPs) are a class of proteins that are able to bind to and inhibit the growth of macromolecular ice, thereby permitting an organism to survive subzero temperatures by decreasing the probability of ice nucleation in their bodies [ ]. These proteins have been characterised from a variety of organisms...

[]

0

[ "PFAM" ]

[ "PF05264" ]

[ "CfAFP" ]

[ 50 ]

1

[]

0

[ "1eww", "1l0s", "1m8n", "1n4i", "1z2f" ]

5

[ "PUB00015094", "PUB00015095" ]

[ "15291806", "12015145" ]

[ "Cold survival in freeze-intolerant insects: the structure and function of beta-helical antifreeze proteins.", "Crystal structure of beta-helical antifreeze protein points to a general ice binding model." ]

[ 2004, 2002 ]

2

[]

0

null

[ "Choristoneura" ]

[ 50 ]

1

[]

0

true

Family

Choristoneura fumiferana antifreeze

Antifreeze_CF

5

IPR007929

7,929

Protein of unknown function DUF723

DUF723

Family

786

false

This family contains uncharacterised proteins from Bacteria and viruses. These proteins may have a role in DNA binding.

[]

0

[ "PFAM" ]

[ "PF05265" ]

[ "DUF723" ]

[ 786 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 288, 40, 427, 31 ]

4

[]

0

true

Family

Protein of unknown function DUF723

DUF723

2

IPR007930

7,930

Protein of unknown function DUF724

DUF724

Family

2,256

false

Proteins in this family may be involved in the polar growth of plant cells via transportation of RNAs [ ].

[]

0

[ "PFAM" ]

[ "PF05266" ]

[ "DUF724" ]

[ 2256 ]

1

[]

0

[]

0

[ "PUB00086467" ]

[ "19795213" ]

[ "Characterization of DUF724 gene family in Arabidopsis thaliana." ]

[ 2010 ]

1

[]

0

null

[ "Mesangiospermae" ]

[ 2256 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 49, 21, 23 ]

3

true

Family

Protein of unknown function DUF724

DUF724

5

IPR007931

7,931

Protein TsetseEP

TsetseEP

Domain

652

false

This domain can be found in tsetseEP, a gut protein from the tsetse Glossina morsitans. Towards the C terminus, the protein contains 59 (EP) repeats [ ].

[]

0

[ "PFAM" ]

[ "PF05267" ]

[ "DUF725" ]

[ 652 ]

1

[]

0

[]

0

[ "PUB00086468" ]

[ "15522612" ]

[ "TsetseEP, a gut protein from the tsetse Glossina morsitans, is related to a major surface glycoprotein of trypanosomes transmitted by the fly and to the products of a Drosophila gene family." ]

[ 2004 ]

1

[]

0

null

[ "Neoptera" ]

[ 652 ]

1

[ "Drosophila melanogaster" ]

[ 39 ]

1

true

Domain

Protein TsetseEP

TsetseEP

4

IPR007932

7,932

Receptor-recognising protein Gp38

Receptor-recog_Gp38

Domain

474

false

T-even bacteriophages recognise their cellular receptors with the free ends of their six long tail fibres. The Gp38 protein from bacteriophage T2 and related phages is located at the tip of the tail fibre, where it recognises the host receptor [ ]. OmpC has been identified as the host receptor, and sequence variations ...

[]

0

[ "PFAM" ]

[ "PF05268" ]

[ "GP38" ]

[ 474 ]

1

[]

0

[ "6f45" ]

1

[ "PUB00056598", "PUB00056599" ]

[ "3543378", "11029414" ]

[ "Morphogenesis of the long tail fibers of bacteriophage T2 involves proteolytic processing of the polypeptide (gene product 37) constituting the distal part of the fiber.", "Characterization of the distal tail fiber locus and determination of the receptor for phage AR1, which specifically infects Escherichia coli...

[ 1986, 2000 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 229, 2, 237, 6 ]

4

[]

0

true

Domain

Receptor-recognising protein Gp38

Receptor-recog_Gp38

8

IPR007933

7,933

Transcription activator CII

Transcrpt_activ_CII

Family

1,775

false

The CII protein is a transcription activator, conserved in bacteriophage lambda and related phages, that plays a key role in the decision between lytic or lysogenic phage development. CII is regulated at multiple levels including transcription, translation initiation, mRNA stability, and proteolysis [ ]. Conditions tha...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05269" ]

[ "Phage_CII" ]

[ 1775 ]

1

[]

0

[ "1xwr", "1zpq", "1zs4", "8igr" ]

4

[ "PUB00010448", "PUB00038382", "PUB00038981" ]

[ "12397182", "16061804", "16039594" ]

[ "The phage lambda CII transcriptional activator carries a C-terminal domain signaling for rapid proteolysis.", "Structure of lambda CII: implications for recognition of direct-repeat DNA by an unusual tetrameric organization.", "Crystal structure of bacteriophage lambda cII and its DNA complex." ]

[ 2002, 2005, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 1632, 3, 140 ]

3

[]

0

true

Family

Transcription activator CII

Transcrpt_activ_CII

3

IPR007935

7,935

Tobravirus 2B

Tobravirus_2B

Family

22

false

This family consists of several tobravirus 2B proteins. It is known that the 2B protein is required for transmission by both Paratrichodorus pachydermus and Paratrichodorus anemones nematodes [ ]. Transmission of the tobraviruses Tobacco rattle virus by trichodorid vector nematodes requires the viral coat protein (CP) ...

[]

0

[ "PFAM" ]

[ "PF05271" ]

[ "Tobravirus_2B" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00010450", "PUB00010451" ]

[ "11162804", "12202212" ]

[ "Tobravirus 2b protein acts in trans to facilitate transmission by nematodes.", "Immunogold localization of tobravirus 2b nematode transmission helper protein associated with virus particles." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Tobravirus" ]

[ 22 ]

1

[]

0

true

Family

Tobravirus 2B

Tobravirus_2B

9

IPR007936

7,936

Virulence-associated protein E-like domain

VapE-like_dom

Domain

6,536

false

This domain is found in VapE (virulence-associated protein E, ) from Dichelobacter nodosus and similar proteins, mainly from bacteria.

[]

0

[ "PFAM" ]

[ "PF05272" ]

[ "VapE-like_dom" ]

[ 6536 ]

1

[]

0

[ "7pds" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomethylophilus alvi", "Viruses", "unclassified sequences" ]

[ 6055, 13, 2, 364, 102 ]

5

[]

0

true

Domain

Virulence-associated protein E-like domain

VapE-like_dom

4

IPR007937

7,937

RNA polymerase, 22kDa subunit, poxviral

RNA_Pol_22kDa_poxvir

Family

106

false

Vaccinia viral RNA synthesis is carried out by a virus coded, multi-subunit, eukaryotic-like RNA polymerase. RNA polymerase subunits are synthesized throughout infection and the assembled RNA polymerase is packaged into nascent virions late in infection. The RNA polymerase exists in two different forms, one specific fo...

[ "GO:0003677", "GO:0003899", "GO:0019083" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "viral transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF" ]

[ "PF05273", "PIRSF000744" ]

[ "Pox_RNA_Pol_22", "RPO22" ]

[ 106, 97 ]

2

[ "EC" ]

[ "2.7.7.6" ]

[ "EC:2.7.7.6" ]

1

[ "6rfl", "6ric", "6rid", "6rie", "7amv", "7aof", "7aoh", "7aoz", "7ap8", "7ap9", "8c8h", "8p0j", "8p0k", "8p0n", "8rqk", "9ex9", "9fpy", "9fq6" ]

18

[]

0

[]

0

null

[ "Chordopoxvirinae" ]

[ 106 ]

1

[]

0

true

Family

RNA polymerase, 22kDa subunit, poxviral

RNA_Pol_22kDa_poxvir

2

IPR007938

7,938

Baculovirus occlusion-derived virus envelope, E25

Baculo_ODV-E25

Family

137

false

This family consists of several nucleopolyhedrovirus occlusion-derived virus envelope E25 proteins. The N terminus of this protein is extremely hydrophobic, studies suggest that this defined hydrophobic domain is sufficient to direct the protein to induced membrane microvesicles within a baculovirus-infected cell nucle...

[ "GO:0019031" ]

[ "viral envelope" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05274" ]

[ "Baculo_E25" ]

[ 137 ]

1

[]

0

[]

0

[ "PUB00008001" ]

[ "9108103" ]

[ "N-terminal sequences from Autographa californica nuclear polyhedrosis virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct reporter proteins to the nuclear envelope, intranuclear microvesicles and the envelope of occlusion derived virus." ]

[ 1997 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 137 ]

1

[]

0

true

Family

Baculovirus occlusion-derived virus envelope, E25

Baculo_ODV-E25

7

IPR007939

7,939

Copper resistance B precursor

Cu-R_B_prcur

Family

4,955

false

This family consists of several bacterial copper resistance proteins. Copper is essential and serves as a cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to free radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organism. CopB serves...

[ "GO:0005507", "GO:0006878", "GO:0009279" ]

[ "copper ion binding", "intracellular copper ion homeostasis", "cell outer membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05275" ]

[ "CopB" ]

[ 4955 ]

1

[]

0

[ "7pge" ]

1

[ "PUB00010452" ]

[ "11696373" ]

[ "Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4885, 11, 59 ]

3

[ "Oryza sativa subsp. japonica" ]

[ 1 ]

1

true

Family

Copper resistance B precursor

Cu-R_B_prcur

8

IPR007941

7,941

Protein of unknown function DUF726

DUF726

Family

8,229

false

This family consists of transmembrane and coiled-coil domain-containing proteins found in animal and plant organisms, uncharacterised membrane proteins in eukaryotes, and uncharacterised proteins in prokaryotes. Some of these proteins have an alpha/beta hydrolase domain .

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05277", "PTHR17920" ]

[ "DUF726", "" ]

[ 8123, 7899 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 159, 544, 7522, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 16, 1, 5, 3, 1, 3, 4, 4, 1, 2, 15 ]

11

true

Family

Protein of unknown function DUF726

DUF726

7

IPR007942

7,942

Phospholipase-like

PLipase-like

Family

1,928

false

This family contains several phospholipase-like proteins from Arabidopsis thaliana and other members of the Streptophyta which are homologous to PEARLI 4.

[]

0

[ "PFAM" ]

[ "PF05278" ]

[ "PEARLI-4" ]

[ 1928 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Azospirillum formosense", "Mesangiospermae", "Plutella xylostella granulovirus", "hydrothermal vent metagenome" ]

[ 1, 1924, 2, 1 ]

4

[ "Arabidopsis thaliana" ]

[ 72 ]

1

true

Family

Phospholipase-like

PLipase-like

4

IPR007943

7,943

Aspartyl beta-hydroxylase/Triadin domain

Asp-B-hydro/Triadin_dom

Domain

4,301

false

This domain is found in members of the junctin, junctate and aspartyl beta-hydroxylase protein families. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin [ ]. Aspartyl beta-hydroxylase cat...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05279" ]

[ "Asp-B-Hydro_N" ]

[ 4301 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2672351", "R-BTA-5578775", "R-HSA-2672351", "R-HSA-5578775", "R-HSA-9629569", "R-MMU-2672351", "R-MMU-5578775", "R-RNO-2672351", "R-RNO-5578775" ]

[ "REACTOME:R-BTA-2672351", "REACTOME:R-BTA-5578775", "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-5578775", "REACTOME:R-HSA-9629569", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-5578775", "REACTOME:R-RNO-2672351", "REACTOME:R-RNO-5578775" ]

9

[]

0

[ "PUB00010454", "PUB00010455", "PUB00013026" ]

[ "11735129", "11773073", "11707337" ]

[ "Molecular cloning and characterization of mouse cardiac junctate isoforms.", "Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia.", "Molecular cloning and characterization of mous...

[ 2001, 2002, 2001 ]

3

[]

0

null

[ "Chordata", "Kangiella spongicola" ]

[ 4300, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 21, 30, 19 ]

4

true

Domain

Aspartyl beta-hydroxylase/Triadin domain

Asp-B-hydro/Triadin_dom

3

IPR007944

7,944

Flagellar transcriptional activator FlhC

FlhC

Family

3,520

false

This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in Escherichia coli, this complex has been shown to be a global regulator involved in many cellular processes as well as a flagellar transcriptional activator [ ].

[ "GO:0003677", "GO:0045893", "GO:1902208" ]

[ "DNA binding", "positive regulation of DNA-templated transcription", "regulation of bacterial-type flagellum assembly" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_01891", "NF009365", "PF05280", "PIRSF003159" ]

[ "FhlC", "PRK12722.1", "FlhC", "FlhC" ]

[ 2726, 2782, 3520, 2750 ]

4

[]

0

[ "2avu", "8j56" ]

2

[ "PUB00010441", "PUB00056774", "PUB00104122", "PUB00104123" ]

[ "11287152", "7961507", "10586519", "9287017" ]

[ "FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions.", "The FlhD/FlhC complex, a transcriptional activator of the Escherichia coli flagellar class II operons.", "Structure and transcriptional control of the flagellar master operon of Salmonella typhimurium.", "Negative feedback from a ...

[ 2001, 1994, 1999, 1997 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3492, 8, 20 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar transcriptional activator FlhC

FlhC

7

IPR007945

7,945

Neuroendocrine 7B2 precursor

Secretogranin_V

Family

1,865

false

Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [ ]. Protein 7B2 (secretogranin V) functions as a molecular chaperone for PC2, preventing its premature activation in the regulated secretory pathway [ ]. 7B2 represents a p...

[ "GO:0007218", "GO:0030141" ]

[ "neuropeptide signaling pathway", "secretory granule" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05281", "PTHR12738" ]

[ "Secretogranin_V", "" ]

[ 1801, 1823 ]

2

[]

0

[]

0

[ "PUB00014512", "PUB00071624", "PUB00071625", "PUB00071626", "PUB00093453", "PUB00093454" ]

[ "10506829", "10701998", "11439082", "7913882", "29955078", "23172224" ]

[ "The cell biology of the prohormone convertases PC1 and PC2.", "Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.", "Neuroendocrine secretory protein 7B2: structure, expression and functions.", "7B2 is a neuroendocrine chaperone that transiently interacts...

[ 1999, 1999, 2001, 1994, 2018, 2013 ]

6

[]

0

null

[ "Bilateria" ]

[ 1865 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 6, 2, 3 ]

6

true

Family

Neuroendocrine 7B2 precursor

Secretogranin_V

2

IPR007946

7,946

A1 cistron-splicing factor, AAR2

AAR2

Family

4,197

false

This family consists of several eukaryotic AAR2-like proteins. The Saccharomyces cerevisiae protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth [ ].

[]

0

[ "PANTHER" ]

[ "PTHR12689" ]

[ "" ]

[ 4197 ]

1

[]

0

[ "3sbs", "3sbt", "3zef", "4i43", "4ilg", "4ilh", "4ili", "5qy1", "5qy2", "5qy3", "5qy4", "5qy5", "5qy6", "5qy7", "5qy8", "5qy9", "5qya", "5qyb", "5qyc", "5qyd", "5qye", "5qyf", "5qyg", "5qyh", "5qyi", "5qyj", "5qyk", "5qyl", "5qym", "5qyn", "5qyo", "5qyp"...

402

[ "PUB00010457" ]

[ "1922071" ]

[ "AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae." ]

[ 1991 ]

1

[]

0

null

[ "Cyanophyceae", "Eukaryota", "marine sediment metagenome" ]

[ 5, 4189, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 2, 3, 4, 4, 1, 4, 4, 1, 1, 12 ]

12

true

Family

A1 cistron-splicing factor, AAR2

AAR2

6

IPR007947

7,947

CD164-related protein

CD164_MGC24

Family

2,937

false

CD164 is a mucin-like receptor, or sialomucin, with specificity in receptor/ ligand interactions that depends on the structural characteristics of the mucin-like receptor. Its functions include mediating, or regulating, haematopoietic progenitor cell adhesion and the negative regulation of their growth and/or-different...

[]

0

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF05283", "PR01701", "PTHR11337" ]

[ "MGC-24", "CD164ANTIGEN", "" ]

[ 2761, 503, 2834 ]

3

[]

0

[]

0

[ "PUB00010336", "PUB00010352", "PUB00010372" ]

[ "9763543", "10491205", "11027692" ]

[ "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis.", "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164.", "Relationship between novel isoforms, funct...

[ 1998, 1999, 2001 ]

3

[]

0

null

[ "Amycolatopsis thermalba", "Eukaryota" ]

[ 1, 2936 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 3, 8, 8, 12 ]

6

true

Family

CD164-related protein

CD164_MGC24

7

IPR007948

7,948

Protein of unknown function DUF736

DUF736

Family

5,247

false

This family consists of several uncharacterised bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF05284" ]

[ "DUF736" ]

[ 5247 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaeoglobaceae", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 4, 5188, 3, 20, 32 ]

5

[]

0

true

Family

Protein of unknown function DUF736

DUF736

5

IPR007949

7,949

SDA1, middle domain

SDA1_MD

Domain

3,897

false

This domain is found in several SDA1 protein homologues. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localised in the nucleus [ ].

[]

0

[ "PFAM" ]

[ "PF05285" ]

[ "SDA1_dom" ]

[ 3897 ]

1

[]

0

[ "5jcs", "6ylg", "6ylh", "8fl2", "8fl3", "8fl4", "8idy", "8inf", "8ink", "8ipy", "8pv4", "8pv6", "8pv8" ]

13

[ "PUB00010459" ]

[ "10704371" ]

[ "The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3897 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", ...

[ 1, 1, 1, 3, 3, 1, 2, 4, 1, 1, 1 ]

11

true

Domain

SDA1, middle domain

SDA1_MD

9

IPR007951

7,951

Keratin-associated protein, PMG type

KRTAP_PMG

Family

1,535

false

This entry represents the keratin-associated proteins, PMG type [ ]. The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which a...

[]

0

[ "PFAM" ]

[ "PF05287" ]

[ "PMG" ]

[ 1535 ]

1

[ "REACTOME" ]

[ "R-HSA-6805567" ]

[ "REACTOME:R-HSA-6805567" ]

1

[]

0

[ "PUB00010461" ]

[ "10446281" ]

[ "Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota", "Streptococcus ovuberis" ]

[ 1534, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 18, 23 ]

3

true

Family

Keratin-associated protein, PMG type

KRTAP_PMG

3

IPR007952

7,952

Poxvirus A2.5L

Poxvirus_A2.5L

Family

153

false

This family represents A2.5L from Vaccinia virus, also known as Protein OPG128, and similar sequences from poxvirus. A2.5L is a late protein which probably participates in disulfide bond formation by functioning as a thiol-disulfide transfer protein between membrane-associated OPG072 and OPG08 [ ]. It is an all-α-helic...

[]

0

[ "PFAM" ]

[ "PF05288" ]

[ "Pox_A3L" ]

[ 153 ]

1

[]

0

[]

0

[ "PUB00010462", "PUB00010463", "PUB00013605" ]

[ "10729126", "12350360", "11983854" ]

[ "Characterization of vaccinia virus intracellular cores: implications for viral uncoating and core structure.", "Expression of the vaccinia virus A2.5L redox protein is required for virion morphogenesis.", "Complete pathway for protein disulfide bond formation encoded by poxviruses." ]

[ 2000, 2002, 2002 ]

3

[]

0

null

[ "Poxviridae" ]

[ 153 ]

1

[]

0

true

Family

Poxvirus A2.5L

Poxvirus_A2.5L

8

IPR007953

7,953

Holin-like, BlyB

Holin-like_BlyB

Family

318

false

This entry represents the borrelial prophage-encoded protein BlyB. Originally BlyB and its partner, the membrane-bound protein BlyA, were thought to comprise a haemolysis system. It is now thought, however, that BlyA and BlyB function instead as a holin or holin-like system [ ].

[]

0

[ "PFAM" ]

[ "PF05289" ]

[ "BLYB" ]

[ 318 ]

1

[]

0

[]

0

[ "PUB00009741" ]

[ "11073925" ]

[ "Characterization of Borrelia burgdorferi BlyA and BlyB proteins: a prophage-encoded holin-like system." ]

[ 2000 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 318 ]

1

[]

0

true

Family

Holin-like, BlyB

Holin-like_BlyB

5

IPR007954

7,954

Baculovirus immediate-early

Baculo_IE-1

Family

105

false

This entry contains the Baculovirus immediate-early protein IE-0.

[]

0

[ "PFAM" ]

[ "PF05290" ]

[ "Baculo_IE-1" ]

[ 105 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphabaculovirus" ]

[ 105 ]

1

[]

0

true

Family

Baculovirus immediate-early

Baculo_IE-1

9

IPR007955

7,955

Bystin

Family

4,893

false

Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast inv...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05291", "PTHR12821" ]

[ "Bystin", "" ]

[ 4796, 4817 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226" ]

4

[ "5wlc", "5wwo", "5wyj", "6eml", "6fai", "6g18", "6g4s", "6g4w", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqu", "6lqv", "6rbd", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6y7c", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "6zqg", "7ajt", "7aju"...

66

[ "PUB00010465", "PUB00010466", "PUB00010467" ]

[ "9560222", "9034325", "12527778" ]

[ "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells.", "ENP1, an essential gene encoding a nuclear protein that is highly conserved from yeast to humans.", "Enp1, a yeast pr...

[ 1998, 1997, 2003 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4892, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 3, 2, 1, 5, 3, 1, 1, 9 ]

12

true

Family

Bystin

2

IPR007957

7,957

African swine fever virus L11L

ASFV_L11L

Family

18

false

L11L is an integral membrane protein of the African swine fever virus, which is expressed late in the virus replication cycle. The protein is thought to be non-essential for growth in vitro and for virus virulence in domestic pigs ].

[]

0

[ "PFAM" ]

[ "PF05293" ]

[ "ASFV_L11L" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00010469" ]

[ "9603334" ]

[ "A conserved African swine fever virus right variable region gene, l11L, is non-essential for growth in vitro and virulence in domestic swine." ]

[ 1998 ]

1

[]

0

null

[ "African swine fever virus" ]

[ 18 ]

1

[]

0

true

Family

African swine fever virus L11L

ASFV_L11L

6

IPR007958

7,958

Scorpion short chain toxin, chloride channel inhibitor

Scorpion_toxinS_Cl_inh

Family

78

false

Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulphide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8 [ , , ]. The global fold of the scorpion short t...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05294", "PS51200" ]

[ "Toxin_5", "SHORT_SCORPION_CHLORIDE" ]

[ 40, 78 ]

2

[ "PROSITEDOC" ]

[ "PDOC51200" ]

[ "PROSITEDOC:PDOC51200" ]

1

[ "1chl", "1sis", "5l1c", "6atw", "6ava", "7soh", "7x41", "7x43", "7x44", "7x4d", "8c5g" ]

11

[ "PUB00000410", "PUB00033808", "PUB00033809" ]

[ "7819188", "9210487", "10048185" ]

[ "NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels.", "Solution structure of Lqh-8/6, a toxin-like peptide from a scorpion venom--structural heterogeneity induced by proline cis/trans isomerization.", "Purification and primary structure of low...

[ 1995, 1997, 1998 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 78 ]

1

[]

0

true

Family

Scorpion short chain toxin, chloride channel inhibitor

Scorpion_toxinS_Cl_inh

5

IPR007959

7,959

Dinoflagellate luciferase, N-terminal

Dino_Luciferase_N

Domain

71

false

Proteins in this entry belong to a family of dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme ...

[]

0

[ "PFAM" ]

[ "PF05295" ]

[ "Luciferase_N" ]

[ 71 ]

1

[]

0

[]

0

[ "PUB00010470" ]

[ "11747464" ]

[ "Members of a dinoflagellate luciferase gene family differ in synonymous substitution rates." ]

[ 2001 ]

1

[]

0

null

[ "Sar" ]

[ 71 ]

1

[]

0

true

Domain

Dinoflagellate luciferase, N-terminal

Dino_Luciferase_N

6

IPR007960

7,960

Taste receptor type 2

TAS2R

Family

6,876

false

This family consists of several forms of taste receptor proteins (TAS2Rs) predominantly found in mammals. TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organised in the genome in clusters. The proteins are genetically linked to loci that i...

[ "GO:0004930", "GO:0033038", "GO:0007186", "GO:0050909", "GO:0016020" ]

[ "G protein-coupled receptor activity", "bitter taste receptor activity", "G protein-coupled receptor signaling pathway", "sensory perception of taste", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF05296" ]

[ "TAS2R" ]

[ 6876 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-418594", "R-GGA-420499", "R-GGA-9717207", "R-HSA-418594", "R-HSA-420499", "R-HSA-9717207", "R-MMU-418594", "R-MMU-420499", "R-MMU-9717207", "R-RNO-418594", "R-RNO-420499", "R-RNO-9717207" ]

[ "REACTOME:R-GGA-418594", "REACTOME:R-GGA-420499", "REACTOME:R-GGA-9717207", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-420499", "REACTOME:R-HSA-9717207", "REACTOME:R-MMU-418594", "REACTOME:R-MMU-420499", "REACTOME:R-MMU-9717207", "REACTOME:R-RNO-418594", "REACTOME:R-RNO-420499", "REACTOME:R-RNO-...

12

[ "7xp4", "7xp5", "7xp6", "8rql", "8vy7", "8vy9", "8xql", "8xqn", "8xqo", "8xqp", "8xqr", "8xqs", "8xqt", "8yky", "9iiw", "9iix", "9ij9", "9ija", "9k6l", "9kpd", "9kpe", "9kpf" ]

22

[ "PUB00010471" ]

[ "10761934" ]

[ "A novel family of mammalian taste receptors." ]

[ 2000 ]

1

[]

[ "IPR030050", "IPR030055" ]

0

2

0

[ "Bacillota", "Eukaryota" ]

[ 4, 6872 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 107, 50, 68 ]

4

true

Family

Taste receptor type 2

TAS2R

9

IPR007961

7,961

Herpesvirus latent membrane 1

Herpes_LMP1

Family

1,719

false

This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4). LMP1 of HHV-4 is a 62-65kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N terminus and a long cytoplasmic carboxy tail of 200 amino acid...

[ "GO:0019087", "GO:0016020" ]

[ "symbiont-mediated transformation of host cell", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05297" ]

[ "Herpes_LMP1" ]

[ 1719 ]

1

[]

0

[ "8xh6", "8xh7" ]

2

[ "PUB00010472" ]

[ "12457963" ]

[ "Characterization of the Cyno-EBV LMP1 homologue and comparison with LMP1s of EBV and other EBV-like viruses." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Lymphocryptovirus", "Staphylococcus" ]

[ 6, 1708, 5 ]

3

[]

0

true

Family

Herpesvirus latent membrane 1

Herpes_LMP1

4

IPR007963

7,963

Peptidase M61, catalytic domain

Peptidase_M61_catalytic

Domain

8,130

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[]

0

[ "PFAM" ]

[ "PF05299" ]

[ "Peptidase_M61" ]

[ 8130 ]

1

[]

0

[ "4fgm", "7xyo", "8j9c", "8j9d" ]

4

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 60, 7902, 77, 91 ]

4

[]

0

true

Domain

Peptidase M61, catalytic domain

Peptidase_M61_catalytic

6

IPR007964

7,964

MICOS complex subunit MIC19/MIC25

MIC19/MIC25

Family

2,961

false

MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane [ , ]. MIC19 p...

[ "GO:0005739", "GO:0061617" ]

[ "mitochondrion", "MICOS complex" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05300" ]

[ "MIC19_MIC25" ]

[ 2961 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-1268020", "R-HSA-8949613" ]

[ "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-8949613" ]

2

[]

0

[ "PUB00086469", "PUB00086470" ]

[ "21081504", "22228767" ]

[ "ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.", "CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology." ]

[ 2011, 2012 ]

2

[]

[ "IPR042860" ]

0

1

0

[ "Opisthokonta" ]

[ 2961 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 10, 10, 11 ]

4

true

Family

MICOS complex subunit MIC19/MIC25

MIC19/MIC25

1

IPR007965

7,965

Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type

GNAT_ATAT

Domain

2,791

false

The N-acetyltransferases (NAT) (EC 2.3.1.-) are enzymes that use acetyl coenzyme A (CoA) to transfer an acetyl group to a substrate, a reaction implicated in various functions from bacterial antibiotic resistance to mammalian circadian rhythm and chromatin remodeling. The Gcn5-related N-acetyltransferases (GNAT) cataly...

[ "GO:0019799", "GO:0071929", "GO:0005874" ]

[ "tubulin N-acetyltransferase activity", "alpha-tubulin acetylation", "microtubule" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PROFILE" ]

[ "MF_03130", "PF05301", "PS51730" ]

[ "mec17", "Acetyltransf_16", "GNAT_ATAT" ]

[ 2272, 2769, 2776 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1.108", "R-BTA-5617833", "R-HSA-5617833", "R-MMU-5617833", "R-PFA-5617833", "R-RNO-5617833", "R-XTR-5617833" ]

[ "EC:2.3.1.108", "REACTOME:R-BTA-5617833", "REACTOME:R-HSA-5617833", "REACTOME:R-MMU-5617833", "REACTOME:R-PFA-5617833", "REACTOME:R-RNO-5617833", "REACTOME:R-XTR-5617833" ]

7

[ "3vwd", "3vwe", "4b5o", "4b5p", "4gs4", "4h6u", "4h6z", "4hkf", "4if5", "4pk2", "4pk3", "4u9y", "4u9z", "4yrh", "8y9f", "8yaj", "8yal", "8yar" ]

18

[ "PUB00005463", "PUB00025257", "PUB00027579", "PUB00033792", "PUB00033793", "PUB00053857", "PUB00064792", "PUB00074836", "PUB00074837" ]

[ "9175471", "12527305", "12592013", "10940244", "15581578", "12124626", "20829795", "23894642", "23105108" ]

[ "GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.", "Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.", "X-ray structure of the AAC(6')-Ii antibiotic resistance enz...

[ 1997, 2003, 2003, 2000, 2005, 2002, 2010, 2013, 2012 ]

9

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 2789 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 3, 5, 4, 11 ]

6

true

Domain

Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type

GNAT_ATAT

7

IPR007966

7,966

Protein of unknown function DUF720

DUF720

Family

89

false

This family consists of several uncharacterised Chlamydia proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF05302" ]

[ "DUF720" ]

[ 89 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 89 ]

1

[]

0

true

Family

Protein of unknown function DUF720

DUF720

4

IPR007967

7,967

GSKIP domain

GSKIP_dom

Domain

3,697

false

This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta [ ]. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria [ , , ].

[]

0

[ "PFAM" ]

[ "PF05303" ]

[ "GSKIP_dom" ]

[ 3697 ]

1

[]

0

[ "1sgo" ]

1

[ "PUB00054079", "PUB00064791", "PUB00068099", "PUB00068100" ]

[ "16981698", "19638420", "14617080", "9601101" ]

[ "GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.", "Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.", "The genetic control of plant mitochondrial morphology and dynamics."...

[ 2006, 2009, 2003, 1998 ]

4

[]

0

null

[ "Eukaryota", "Ruminococcus intestinalis" ]

[ 3696, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 7, 12, 2, 5, 3, 3, 3, 38 ]

8

true

Domain

GSKIP domain

GSKIP_dom

2

IPR007969

7,969

Domain of unknown function DUF732

DUF732

Domain

6,361

false

This entry represents several uncharacterised Mycobacterium tuberculosis proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF05305" ]

[ "DUF732" ]

[ 6361 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Caudoviricetes", "Phytophthora fragariaefolia", "freshwater metagenome" ]

[ 6003, 354, 1, 3 ]

4

[]

0

true

Domain

Domain of unknown function DUF732

DUF732

9

IPR007972

7,972

Mitochondrial fission regulator 1

Mtfr1

Family

3,491

false

Mitochondrial fission regulator 1 has been described in mammals, where it induces mitochondrial fission [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05308", "PTHR14215" ]

[ "Mito_fiss_reg", "" ]

[ 3353, 3420 ]

2

[]

0

[]

0

[ "PUB00057499", "PUB00057500" ]

[ "15389597", "20568109" ]

[ "Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission.", "The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration." ]

[ 2004, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3491 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 24, 14, 16 ]

4

true

Family

Mitochondrial fission regulator 1

Mtfr1

9

IPR007973

7,973

Pilus assembly TraE

Pilus_assembly_TraE

Family

2,639

false

This family consists of several bacterial sex pilus assembly and synthesis proteins (TraE). Conjugal transfer of plasmids from donor to recipient cells is a complex process in which a cell-to-cell contact plays a key role. Many genes encoded by self-transmissible plasmids are required for various processes of conjugati...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05309", "TIGR02761" ]

[ "TraE", "TraE_TIGR" ]

[ 2639, 886 ]

2

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[]

0

[ "PUB00010475" ]

[ "10760136" ]

[ "The transfer region of IncI1 plasmid R64: similarities between R64 tra and legionella icm/dot genes." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2617, 10, 12 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pilus assembly TraE

Pilus_assembly_TraE

3

IPR007974

7,974

Tenuivirus movement protein

Tenui_movmnt_prot

Family

195

false

This family of ssRNA negative-strand crop plant tenuivirus proteins appears to combine PV2 [ ], NS2 [ ], NS3, and PV3 proteins. Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-depe...

[]

0

[ "PFAM" ]

[ "PF05310" ]

[ "Tenui_NS3" ]

[ 195 ]

1

[]

0

[ "3ajf" ]

1

[ "PUB00013120", "PUB00055606", "PUB00055607" ]

[ "8883361", "18818319", "19251298" ]

[ "Maize stripe tenuivirus RNA2 transcripts in plant and insect hosts and analysis of pvc2, a protein similar to the Phlebovirus virion membrane glycoproteins.", "Identification of a movement protein of the tenuivirus rice stripe virus.", "Characterization and subcellular localization of an RNA silencing suppress...

[ 1996, 2008, 2009 ]

3

[]

0

null

[ "Tenuivirus" ]

[ 195 ]

1

[]

0

true

Family

Tenuivirus movement protein

Tenui_movmnt_prot

7

IPR007978

7,978

Baculovirus occlusion-derived virus envelope EC27

Baculo_ODV-E27

Family

134

false

This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 or E27) which appear to act as a multifuntional cyclins during the host cell cycle. The ODV-E27 protein has distinct functional characteristics compared to cellular and viral cyclins. When associated with cdc2, it exhibits cycli...

[ "GO:0019031" ]

[ "viral envelope" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05314" ]

[ "Baculo_ODV-E27" ]

[ 134 ]

1

[]

0

[ "8i8b", "8i8c", "8vwi", "8vwj", "9h2a", "9h2b", "9h2c", "9h2h", "9h2j" ]

9

[ "PUB00010479" ]

[ "9736714" ]

[ "The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin." ]

[ 1998 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 134 ]

1

[]

0

true

Family

Baculovirus occlusion-derived virus envelope EC27

Baculo_ODV-E27

9

IPR007979

7,979

Type II restriction enzyme NlaIII/ICEA1

NlaIII/ICEA1

Family

190

false

Endonuclease NlaIII recognises the double-stranded sequence CATG and cleaves after G-4 [ ]. This family also includes ICEA1, a CATG-recognising restriction endonuclease from Helicobacter pylori [ ]. ICEA1 is speculated to be associated with peptic ulcer disease [ ].

[]

0

[ "PFAM" ]

[ "PF05315" ]

[ "ICEA" ]

[ 190 ]

1

[]

0

[]

0

[ "PUB00010480", "PUB00062153", "PUB00062154" ]

[ "11843964", "8996109", "12202769" ]

[ "Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong.", "Molecular cloning and expression of NlaIII restriction-modification system in E. coli.", "Functional analysis of iceA1, a CATG-recognizing restriction endonuclease gene in Helicobacter pylori." ]

[ 2001, 1996, 2002 ]

3

[]

0

null

[ "Bacteria", "Haloferacaceae", "Imitervirales", "metagenomes" ]

[ 168, 8, 3, 11 ]

4

[]

0

true

Family

Type II restriction enzyme NlaIII/ICEA1

NlaIII/ICEA1

3

IPR007980

7,980

Small ribosomal subunit protein uS3m, fungi

Ribosomal_uS3m_fun

Family

638

false

This entry represents the fungal small ribosomal subunit protein uS3m, previously known as VAR1. This family consists of the VAR1 mitochondrial ribosomal proteins found in yeast and related proteins which are essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits [ ]. ...

[ "GO:0003735", "GO:0006412" ]

[ "structural constituent of ribosome", "translation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05316" ]

[ "VAR1" ]

[ 638 ]

1

[]

0

[ "5mrc", "5mre", "5mrf", "8d8k", "8d8l", "8om2", "8om3", "8om4" ]

8

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00010481", "PUB00010482", "PUB00098057" ]

[ "11297922", "11290319", "11114498", "8988258", "7770043", "28154081" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Molecular genetics of the peptidyl transferase center and the unusual Var1 protein in yeast mitochondrial ribosomes.", "Incorporation of the yeast mitochondri...

[ 2001, 2001, 2000, 1996, 1995, 2017 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 636 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Small ribosomal subunit protein uS3m, fungi

Ribosomal_uS3m_fun

2

IPR007981

7,981

Peptidase A5, thermopsin

Peptidase_A5

Family

409

false

This group of aspartic peptidases belong to the MEROPS peptidase family A5 (thermopsin family, clan A-). Currently the protein fold and active site residues are not known for any members of this family. The type example is thermopsin from Sulfolobus acidocaldarius. Thermopsin is a thermostable acid protease which is ca...

[]

0

[ "PFAM" ]

[ "PF05317" ]

[ "Thermopsin" ]

[ 409 ]

1

[]

0

[]

0

[ "PUB00000093", "PUB00000349", "PUB00000522", "PUB00001330", "PUB00010483", "PUB00011023", "PUB00011707", "PUB00021296", "PUB00042504", "PUB00065205", "PUB00066803", "PUB00076784", "PUB00076785", "PUB00076786" ]

[ "2194475", "1851433", "8439290", "6795036", "2104844", "10331925", "11566868", "10864493", "2682266", "23254940", "21765428", "4912600", "10497172", "21751400" ]

[ "The structure and function of the aspartic proteinases.", "Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.", "Evolutionary families of peptidases.", "Gastric proteinases--structure, function, evolution and mechanism of action.", "Enzymic properties of therm...

[ 1990, 1991, 1993, 1981, 1990, 1999, 2001, 2000, 1989, 2013, 2011, 1970, 1999, 2011 ]

14

[]

0

null

[ "Archaea", "mine drainage metagenome" ]

[ 387, 22 ]

2

[]

0

true

Family

Peptidase A5, thermopsin

Peptidase_A5

8

IPR007982

7,982

Tombusvirus movement

Tombusvirus_movement

Family

136

false

This family consists of several Tombusvirus movement proteins. These proteins allow the virus to move from cell-to-cell and allow host-specific systemic spread [ ].

[]

0

[ "PFAM" ]

[ "PF05318" ]

[ "Tombus_movement" ]

[ 136 ]

1

[]

0

[]

0

[ "PUB00010484" ]

[ "11483749" ]

[ "Conversion in the requirement of coat protein in cell-to-cell movement mediated by the cucumber mosaic virus movement protein." ]

[ 2001 ]

1

[]

0

null

[ "Riboviria" ]

[ 136 ]

1

[]

0

true

Family

Tombusvirus movement

Tombusvirus_movement

2

IPR007984

7,984

DNA-directed RNA polymerase, 19kDa subunit, poxviral

DNA-dir_RNA_Pol_19kDa_poxvir

Family

116

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF" ]

[ "PF05320", "PIRSF000743" ]

[ "Pox_RNA_Pol_19", "RPO19" ]

[ 116, 110 ]

2

[ "EC" ]

[ "2.7.7.6" ]

[ "EC:2.7.7.6" ]

1

[ "6rfl", "6ric", "6rid", "6rie", "7amv", "7aof", "7aoh", "7aoz", "7ap8", "7ap9", "8c8h", "8p0j", "8p0k", "8p0n", "8rqk", "9ex9", "9fpy", "9fq6" ]

18

[ "PUB00000061", "PUB00033173" ]

[ "3052291", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 1999 ]

2

[]

0

null

[ "Poxviridae" ]

[ 116 ]

1

[]

0

true

Family

DNA-directed RNA polymerase, 19kDa subunit, poxviral

DNA-dir_RNA_Pol_19kDa_poxvir

1

IPR007985

7,985

Haemolysin expression modulating, HHA

Hemolysn_expr_modulating_HHA

Family

3,037

false

This family consists of haemolysin expression modulating protein (Hha) from Escherichia coli and its enterobacterial homologues, such as YmoA from Yersinia enterocolitica, and RmoA encoded on the R100 plasmid. These proteins act as modulators of bacterial gene expression. Members of the Hha/YmoA/RmoA family act in conj...

[]

0

[ "PFAM" ]

[ "PF05321" ]

[ "HHA" ]

[ 3037 ]

1

[ "GP", "GP" ]

[ "GenProp1182", "GenProp1206" ]

[ "GP:GenProp1182", "GP:GenProp1206" ]

2

[ "1jw2", "2jqt", "2k5s", "2mw2", "4icg" ]

5

[ "PUB00014317", "PUB00014318", "PUB00014319" ]

[ "11790731", "11890540", "9851035" ]

[ "Evidence for direct protein-protein interaction between members of the enterobacterial Hha/YmoA and H-NS families of proteins.", "Role of the Hha/YmoA family of proteins in the thermoregulation of the expression of virulence factors.", "Sequence, identification and effect on conjugation of the rmoA gene of pla...

[ 2002, 2002, 1998 ]

3

[]

0

null

[ "Bacteria", "Thelohanellus kitauei", "metagenomes" ]

[ 3032, 1, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Haemolysin expression modulating, HHA

Hemolysn_expr_modulating_HHA

3

IPR007986

7,986

NINE

Family

948

false

This family consists of NINE proteins from several bacteriophage and from Escherichia coli.

[]

0

[ "PFAM" ]

[ "PF05322" ]

[ "NinE" ]

[ 948 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 861, 87 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NINE

1

IPR007987

7,987

Poxvirus A21

Poxvirus_A21

Family

128

false

This entry represents A21 from Vaccinia virus, also known as Virion membrane protein OPG147, and similar proteins from poxvirus. A21 is an envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. It also plays a role in cell-cell fusion (syn...

[]

0

[ "PFAM" ]

[ "PF05323" ]

[ "Pox_A21" ]

[ 128 ]

1

[]

0

[ "8u0r" ]

1

[ "PUB00103641" ]

[ "16014909" ]

[ "Vaccinia virus A21 virion membrane protein is required for cell entry and fusion." ]

[ 2005 ]

1

[]

0

null

[ "Poxviridae" ]

[ 128 ]

1

[]

0

true

Family

Poxvirus A21

Poxvirus_A21

8