LiteFold/InterPro · Datasets at Hugging Face

IPR007988

7,988

Sperm-associated antigen 11 A/B

Sperm_Ag_11A_B

Family

345

false

This family consists of several variants of the human and chimpanzee (Pan troglodytes) sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins, known as sperm-associated antigen 11. The EP2 gene uses alternative promoters and diffe...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05324", "PTHR14081" ]

[ "Sperm_Ag_HE2", "" ]

[ 252, 343 ]

2

[]

0

[]

0

[ "PUB00010486" ]

[ "10819450" ]

[ "Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2." ]

[ 2000 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 345 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 4, 11 ]

3

true

Family

Sperm-associated antigen 11 A/B

Sperm_Ag_11A_B

6

IPR007989

7,989

Protein of unknown function DUF730

DUF730

Family

49

false

This family consists of several uncharacterised proteins of unknown function, from Arabidopsis and Brassica genera.

[]

0

[ "PFAM" ]

[ "PF05325" ]

[ "DUF730" ]

[ 49 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Brassicaceae" ]

[ 49 ]

1

[ "Arabidopsis thaliana" ]

[ 11 ]

1

true

Family

Protein of unknown function DUF730

DUF730

2

IPR007990

7,990

Prolactin-inducible protein

PIP

Family

279

false

Prolactin-inducible (PIP) is a 17kDa glycoprotein that binds to many proteins including fibrinogen, actin, keratin, myosin, immunoglobulin G, CD4, and human zinc-alpha-2 glycoprotein [ ]. It forms a complex with human serum albumin (HSA) in seminal plasma and may affect male fertility/infertility [ ]. It also acts as a...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05326", "PIRSF002572", "PTHR15096" ]

[ "SVA", "PIP-GCDFP-15", "" ]

[ 279, 129, 265 ]

3

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5223345", "R-MMU-5223345", "R-RNO-5223345" ]

[ "REACTOME:R-HSA-5223345", "REACTOME:R-MMU-5223345", "REACTOME:R-RNO-5223345" ]

3

[ "3es6" ]

1

[ "PUB00010487", "PUB00071415" ]

[ "11178965", "22209935" ]

[ "Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein.", "Human serum albumin as a new interacting partner of prolactin inducible protein in human seminal plasma." ]

[ 2001, 2012 ]

2

[]

0

null

[ "Euteleostomi" ]

[ 279 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 13, 13 ]

3

true

Family

Prolactin-inducible protein

PIP

4

IPR007991

7,991

RNA polymerase I specific transcription initiation factor RRN3

RNA_pol_I_trans_ini_fac_RRN3

Family

5,452

false

This family consists of several eukaryotic proteins which are homologous to the Saccharomyces cerevisiae RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in the S. cerevisiae [ ] RNA polymerase I complex within the nucleolus. In mammalian cells, ...

[ "GO:0001181", "GO:0006361" ]

[ "RNA polymerase I general transcription initiation factor activity", "transcription initiation at RNA polymerase I promoter" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05327", "PTHR12790" ]

[ "RRN3", "" ]

[ 5443, 5370 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-73762", "R-CEL-73772", "R-HSA-73762", "R-HSA-73772", "R-MMU-73762", "R-MMU-73772", "R-SCE-73762", "R-SCE-73772", "R-SPO-73762", "R-SPO-73772" ]

[ "REACTOME:R-CEL-73762", "REACTOME:R-CEL-73772", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73772", "REACTOME:R-MMU-73762", "REACTOME:R-MMU-73772", "REACTOME:R-SCE-73762", "REACTOME:R-SCE-73772", "REACTOME:R-SPO-73762", "REACTOME:R-SPO-73772" ]

10

[ "3tj1", "5g5l", "5n5y", "5n5z", "5n60", "5n61", "5oa1", "6rqh", "6rql", "6rqt", "6rrd", "6rui", "6ruo", "6rwe", "6tps", "7oba" ]

16

[ "PUB00010488", "PUB00010489" ]

[ "8670901", "12015311" ]

[ "RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template.", "Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis." ]

[ 1996, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5452 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 1, 1, 1, 12, 2, 1, 5, 3, 1, 1, 15 ]

12

true

Family

RNA polymerase I specific transcription initiation factor RRN3

RNA_pol_I_trans_ini_fac_RRN3

5

IPR007992

7,992

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS

CybS

Family

3,980

false

This family consists of mitochondrial succinate dehydrogenase [ubiquinone] cytochrome b small subunit CybS (also known an SQR) and import inner membrane translocase subunit Tim18. Members of this subfamily are classified as Type C SQRs because they contain two transmembrane subunits and one heme group. CybS and CybL ar...

[ "GO:0005740", "GO:0016020" ]

[ "mitochondrial envelope", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PANTHER", "CDD" ]

[ "PTHR13337", "cd03496" ]

[ "", "SQR_TypeC_CybS" ]

[ 3938, 3113 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-71403", "R-DME-71403", "R-DRE-71403", "R-HSA-611105", "R-HSA-71403", "R-HSA-9854311", "R-MMU-71403", "R-MMU-9854311", "R-RNO-71403", "R-SCE-71403", "R-SPO-71403", "R-XTR-71403", "R-XTR-9854311" ]

[ "REACTOME:R-CEL-71403", "REACTOME:R-DME-71403", "REACTOME:R-DRE-71403", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-71403", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-71403", "REACTOME:R-MMU-9854311", "REACTOME:R-RNO-71403", "REACTOME:R-SCE-71403", "REACTOME:R-SPO-71403", "REACTOME:R-XTR-71403", ...

13

[ "1yq3", "1yq4", "1zoy", "1zp0", "2fbw", "2h88", "2h89", "2wqy", "3abv", "3ae1", "3ae2", "3ae3", "3ae4", "3ae5", "3ae6", "3ae7", "3ae8", "3ae9", "3aea", "3aeb", "3aec", "3aed", "3aee", "3aef", "3aeg", "3sfd", "3sfe", "3vr8", "3vr9", "3vra", "3vrb", "4ysx"...

54

[ "PUB00038975", "PUB00062970", "PUB00062971", "PUB00062972", "PUB00080935", "PUB00080936", "PUB00080937", "PUB00080938" ]

[ "15989954", "10648604", "10637294", "14504216", "15883710", "16288654", "12844553", "16143825" ]

[ "Crystal structure of mitochondrial respiratory membrane protein complex II.", "Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane.", "Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.",...

[ 2005, 2000, 2000, 2003, 2005, 2005, 2003, 2005 ]

8

[]

0

null

[ "Eukaryota" ]

[ 3980 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 3, 1, 8, 2, 1, 4, 3, 1 ]

9

true

Family

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS

CybS

4

IPR007995

7,995

Protein of unknown function DUF742

DUF742

Family

16,166

false

This family consists of several uncharacterised Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05331", "PTHR36221" ]

[ "DUF742", "" ]

[ 16166, 16066 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 16161, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF742

DUF742

4

IPR007996

7,996

Vesivirus VP2

Vesivirus_VP2

Family

70

false

This family consists of several Calicivirus VP2 proteins [ ]. VP2 is a minor capsid protein encoded by all caliciviruses. It forms a large portal-like assembly at a unique three-fold axis of symmetry, following receptor engagement. This assembly-which was not detected in undecorated virions-is formed of twelve copies o...

[]

0

[ "PFAM" ]

[ "PF05332" ]

[ "Vesi_VP2" ]

[ 70 ]

1

[]

0

[ "6gsi" ]

1

[ "PUB00097361" ]

[ "30626974" ]

[ "Calicivirus VP2 forms a portal-like assembly following receptor engagement." ]

[ 2019 ]

1

[]

0

null

[ "Vesivirus" ]

[ 70 ]

1

[]

0

true

Family

Vesivirus VP2

Vesivirus_VP2

5

IPR007998

7,998

Protein of unknown function DUF719

DUF719

Family

2,922

false

This family consists of several eukaryotic proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05334", "PTHR12842" ]

[ "DUF719", "" ]

[ 2864, 2860 ]

2

[ "REACTOME" ]

[ "R-HSA-6802952" ]

[ "REACTOME:R-HSA-6802952" ]

1

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2922 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 16, 3, 9 ]

5

true

Family

Protein of unknown function DUF719

DUF719

6

IPR007999

7,999

Protein of unknown function DUF745

DUF745

Family

1,001

false

This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05335", "PTHR37161" ]

[ "DUF745", "" ]

[ 893, 975 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pancrustacea" ]

[ 1001 ]

1

[ "Drosophila melanogaster" ]

[ 20 ]

1

true

Family

Protein of unknown function DUF745

DUF745

8

IPR008000

8,000

Rhamnose/fucose mutarotase

Rham/fucose_mutarotase

Family

12,047

false

Mutarotases are enzymes which interconvert the alpha and beta stereoisomers of monosaccharides, enhancing the rate of their metabolism. Proteins in this entry are homologues of the rhamnose mutarotase YiiL ( ) from Escherichia coli, and are often encoded in rhamnose utilisation operons. YiiL is an enzyme which intercon...

[ "GO:0016857" ]

[ "racemase and epimerase activity, acting on carbohydrates and derivatives" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05336" ]

[ "rhaM" ]

[ 12047 ]

1

[ "EC", "GP" ]

[ "5.1.3.32", "GenProp0457" ]

[ "EC:5.1.3.32", "GP:GenProp0457" ]

2

[ "1x8d", "2qlw", "2qlx", "6hhn", "7byu", "7byw" ]

6

[ "PUB00020761", "PUB00020762", "PUB00041539" ]

[ "15876375", "15060078", "17144652" ]

[ "Structural insights into the monosaccharide specificity of Escherichia coli rhamnose mutarotase.", "NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration.", "Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas c...

[ 2005, 2004, 2006 ]

3

[]

[ "IPR013448" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 10577, 1201, 76, 193 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Family

Rhamnose/fucose mutarotase

Rham/fucose_mutarotase

8

IPR008001

8,001

Macrophage colony stimulating factor-1

MCSF-1

Family

1,239

false

Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, os...

[ "GO:0005125", "GO:0008083", "GO:0016020" ]

[ "cytokine activity", "growth factor activity", "membrane" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05337", "PIRSF001948", "PTHR10058" ]

[ "CSF-1", "MCSF-1", "" ]

[ 1168, 164, 1237 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-449836", "R-HSA-6783783", "R-HSA-8957275", "R-HSA-9680350", "R-HSA-9856649", "R-MMU-381426", "R-MMU-449836", "R-MMU-8957275", "R-MMU-9856649", "R-RNO-381426", "R-RNO-449836", "R-RNO-8957275", "R-RNO-9856649" ]

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-449836", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-9680350", "REACTOME:R-HSA-9856649", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-449836", "REACTOME:R-MMU-8957275", "REACTOME:R-MMU-9856649", "REACTOME:R-RNO-381426", "REACTOME:R-R...

14

[ "1hmc", "3ejj", "3uez", "3uf2", "3uf5", "4adf", "4adq", "4fa8", "4wrl", "4wrm", "5lxf" ]

11

[ "PUB00010491", "PUB00010492" ]

[ "11897698", "12379742" ]

[ "Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice.", "The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Euteleostomi", "Lymphocystis disease virus 3" ]

[ 1238, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 8, 7, 7 ]

4

true

Family

Macrophage colony stimulating factor-1

MCSF-1

4

IPR008002

8,002

Herpesvirus, Orf30

Herpes_Orf30

Family

38

false

This entry is represented by the Human herpesvirus 8, Orf30 protein; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF05338" ]

[ "DUF717" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Orthoherpesviridae" ]

[ 38 ]

1

[]

0

true

Family

Herpesvirus, Orf30

Herpes_Orf30

5

IPR008003

8,003

Protein of unknown function DUF739

DUF739

Family

541

false

This entry includes Bacteriophage bIL285, Orf5. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family contains several bacteriophage proteins. Three of the proteins in this family have been labelled putative cro repressor proteins.

[]

0

[ "PFAM" ]

[ "PF05339" ]

[ "DUF739" ]

[ 541 ]

1

[]

0

[ "6to6", "6tri" ]

2

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 379, 159, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF739

DUF739

8

IPR008004

8,004

Protein OCTOPUS-like

OCTOPUS-like

Family

3,472

false

This family consists of several plant proteins, including protein OCTOPUS (OPS, At3g09070) and OPSL1 (At5g01170) from Arabidopsis [ ]. OPS is a membrane-associated protein that regulates phloem differentiation entry [ ]. It is a positive regulator of the brassinosteroid (BR) signaling pathway and sequesters BIN2 to the...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05340", "PTHR31659" ]

[ "DUF740", "" ]

[ 3455, 1854 ]

2

[]

0

[]

0

[ "PUB00091094", "PUB00091095", "PUB00091096" ]

[ "22395740", "26387715", "28652362" ]

[ "OCTOPUS, a polarly localised membrane-associated protein, regulates phloem differentiation entry in Arabidopsis thaliana.", "OCTOPUS Negatively Regulates BIN2 to Control Phloem Differentiation in Arabidopsis thaliana.", "Phosphosite charge rather than shootward localization determines OCTOPUS activity in root ...

[ 2012, 2015, 2017 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3472 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 35, 52 ]

3

true

Family

Protein OCTOPUS-like

OCTOPUS-like

7

IPR008005

8,005

Per os infectivity factor 6

PIF6

Family

138

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) Orf68 (also known as per os infectivity factor 6, PIF6 or ac68). PIF6 is present in both the budded virus (BV) and the occluded-derived virus (ODV). The ac68 gene overlaps the lef3 gene which encodes the single-stranded DNA binding ...

[]

0

[ "PFAM" ]

[ "PF05341" ]

[ "PIF6" ]

[ 138 ]

1

[]

0

[]

0

[ "PUB00082605" ]

[ "22278232" ]

[ "Analysis of the autographa californica multiple nucleopolyhedrovirus overlapping gene pair lef3 and ac68 reveals that AC68 is a per os infectivity factor and that LEF3 is critical, but not essential, for virus replication." ]

[ 2012 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 138 ]

1

[]

0

true

Family

Per os infectivity factor 6

PIF6

6

IPR008006

8,006

Peptidase M26, N-terminal domain

Peptidase_M26_N_dom

Domain

1,146

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004222", "GO:0008270", "GO:0016020" ]

[ "metalloendopeptidase activity", "zinc ion binding", "membrane" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05342" ]

[ "Peptidase_M26_N" ]

[ 1146 ]

1

[ "EC" ]

[ "3.4.24" ]

[ "EC:3.4.24" ]

1

[ "6xja", "6xjb", "7jgj", "7uvk", "7uvl" ]

5

[ "PUB00003579", "PUB00014734", "PUB00036030" ]

[ "7674922", "12841855", "12933834" ]

[ "Evolutionary families of metallopeptidases.", "The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.", "ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract." ...

[ 1995, 2003, 2003 ]

3

[]

0

null

[ "Bacteria", "Halobacteria", "ecological metagenomes" ]

[ 1130, 13, 3 ]

3

[]

0

true

Domain

Peptidase M26, N-terminal domain

Peptidase_M26_N_dom

7

IPR008007

8,007

Peptidase M42

Peptidase_M42

Family

22,734

false

These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk [ ]. Pyrococcus horikoshii contain a thermostable de-blocking aminopeptidase member of this family, which is used commercially for N-terminal protein sequencing [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05343", "PIRSF001123" ]

[ "Peptidase_M42", "PepA_GA" ]

[ 19762, 20141 ]

2

[]

0

[ "1vhe", "1vho", "1xfo", "1y0r", "1y0y", "1ylo", "2cf4", "2fvg", "2gre", "2pe3", "2wyr", "2wzn", "3cpx", "3gb0", "3isx", "3kl9", "3rza", "4p6y", "4wwv", "4x8i", "5ds0", "5l6z", "5ne6", "5ne7", "5ne8", "5ne9", "6f3k", "6nw5", "6r8n" ]

29

[ "PUB00016805", "PUB00020049" ]

[ "8535515", "11798173" ]

[ "A non-essential glutamyl aminopeptidase is required for optimal growth of Lactococcus lactis MG1363 in milk.", "Active site of deblocking aminopeptidase from Pyrococcus horikoshii." ]

[ 1995, 2002 ]

2

[]

[ "IPR017537", "IPR017538" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1130, 21231, 42, 24, 307 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 3 ]

2

true

Family

Peptidase M42

Peptidase_M42

2

IPR008008

8,008

Domain of unknown function DUF746

DUF746

Domain

112

false

This is a short conserved region found in some transposons.

[]

0

[ "PFAM" ]

[ "PF05344" ]

[ "DUF746" ]

[ 112 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ricinus communis" ]

[ 111, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF746

DUF746

3

IPR008010

8,010

Tapt1 family

Tatp1

Family

5,783

false

This family of membrane proteins is conserved in eukaryotes. It includes Tapt1 (transmembrane anterior posterior transformation 1) and homologues. Analysis of mouse Tapt1 has shown it to be involved in patterning of the vertebrate axial skeleton [ ]. Its cellular function is not known, but defective Tapt1 disrupts Golg...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05346", "PTHR13317" ]

[ "DUF747", "" ]

[ 5651, 5730 ]

2

[]

0

[]

0

[ "PUB00044752", "PUB00061987", "PUB00078090", "PUB00078091" ]

[ "17151244", "19325107", "26365339", "21954464" ]

[ "Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.", "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochon...

[ 2007, 2009, 2015, 2011 ]

4

[]

0

null

[ "Eukaryota", "Mycoplasmopsis ciconiae" ]

[ 5782, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 4, 6, 2, 4, 2, 1, 5, 2, 1, 1, 11 ]

12

true

Family

Tapt1 family

Tatp1

4

IPR008011

8,011

Complex 1 LYR protein domain

Complex1_LYR_dom

Domain

23,718

false

Proteins containing this domain include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein ( ) has been shown to play a role in Fe/S cluster biogenesis in mitochondria [ , ]. This group of proteins was named LYR after a highly conserved tripeptide mo...

[]

0

[ "PFAM", "PFAM" ]

[ "PF05347", "PF13232" ]

[ "Complex1_LYR", "Complex1_LYR_1" ]

[ 23666, 52 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1362409", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9854311", "R-BTA-9865881", "R-DDI-1362409", "R-DDI-9865881", "R-DME-1362409", "R-DME-9865881", "R-DRE-1362409", "R-DRE-9865881", "R-HSA-1362409", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9854311", "R-HSA-9865881", "R-MMU-1362409...

[ "REACTOME:R-BTA-1362409", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9854311", "REACTOME:R-BTA-9865881", "REACTOME:R-DDI-1362409", "REACTOME:R-DDI-9865881", "REACTOME:R-DME-1362409", "REACTOME:R-DME-9865881", "REACTOME:R-DRE-1362409", "REACTOME:R-DRE-9865881", "REACTOME...

28

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5ool", "5oom", "5usr", "5wgb", "5wkp", "5wlw", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6nzu", "6odd", "6q9b", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7"...

305

[ "PUB00033646", "PUB00033647" ]

[ "16341090", "16341089" ]

[ "The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria.", "Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins." ]

[ 2006, 2006 ]

2

[]

[ "IPR045291", "IPR045292", "IPR045293", "IPR045294", "IPR045295", "IPR045296", "IPR045297", "IPR045298", "IPR045299", "IPR045300" ]

0

10

0

[ "Eukaryota" ]

[ 23718 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 3, 14, 11, 29, 12, 5, 27, 22, 2, 3, 36 ]

12

true

Domain

Complex 1 LYR protein domain

Complex1_LYR_dom

6

IPR008012

8,012

Proteasome maturation factor Ump1

Ump1

Family

4,254

false

Ump1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Ump1 is required for the correct assembly and enzymatic activation of the proteasome. Ump1 seems to be degraded by the proteasome upon its formation [ , ].

[ "GO:0043248" ]

[ "proteasome assembly" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR12828" ]

[ "" ]

[ 4254 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9907900", "R-DDI-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-SCE-9907900", "R-SPO-9907900" ]

[ "REACTOME:R-BTA-9907900", "REACTOME:R-DDI-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-SCE-9907900", "REACTOME:R-SPO-9907900" ]

6

[ "7ls6", "7lsx", "8qyj", "8qyl", "8qym", "8qyn", "8qys", "8qz9", "8rvl", "8rvo", "8rvp", "8t08", "8tm4", "8tm5", "8tm6", "8u6y", "8yix", "8yiy", "9d0t", "9d35", "9d3i", "9d4u" ]

22

[ "PUB00020523", "PUB00053375" ]

[ "9491890", "17431397" ]

[ "Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.", "beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint." ]

[ 1998, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4254 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 10, 1, 1, 4, 3, 1, 13, 4, 1, 1, 9 ]

11

true

Family

Proteasome maturation factor Ump1

Ump1

4

IPR008013

8,013

GATA-type transcription activator, N-terminal

GATA_N

Domain

2,481

false

GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutations are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors fu...

[ "GO:0003677", "GO:0008270", "GO:0045893", "GO:0005634" ]

[ "DNA binding", "zinc ion binding", "positive regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF05349" ]

[ "GATA-N" ]

[ 2481 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-983231", "R-CFA-983231", "R-GGA-5683826", "R-GGA-983231", "R-HSA-2032785", "R-HSA-400511", "R-HSA-5578768", "R-HSA-5683826", "R-HSA-9690406", "R-HSA-9733709", "R-HSA-9758920", "R-HSA-9823730", "R-HSA-983231", "R-HSA-9925561", "R-HSA-9925563", "R-HSA-9937080", "R-MMU-5683826", ...

[ "REACTOME:R-BTA-983231", "REACTOME:R-CFA-983231", "REACTOME:R-GGA-5683826", "REACTOME:R-GGA-983231", "REACTOME:R-HSA-2032785", "REACTOME:R-HSA-400511", "REACTOME:R-HSA-5578768", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-9690406", "REACTOME:R-HSA-9733709", "REACTOME:R-HSA-9758920", "REACTOME:R-...

20

[ "8vg0", "8vg1" ]

2

[]

0

[]

0

null

[ "Eukaryota", "Paenibacillus monticola" ]

[ 2480, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 6, 11, 9, 10, 1 ]

5

true

Domain

GATA-type transcription activator, N-terminal

GATA_N

6

IPR008014

8,014

Glycogen synthase kinase-3 binding protein

GSK3-bd

Family

769

false

Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived fr...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05350", "PTHR35154" ]

[ "GSK-3_bind", "" ]

[ 744, 745 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-196299", "R-HSA-4641262", "R-MMU-196299", "R-MMU-4641262" ]

[ "REACTOME:R-HSA-196299", "REACTOME:R-HSA-4641262", "REACTOME:R-MMU-196299", "REACTOME:R-MMU-4641262" ]

4

[ "1gng", "3zrk", "3zrl", "3zrm", "4afj", "5oy4" ]

6

[ "PUB00010493" ]

[ "11738041" ]

[ "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation." ]

[ 2001 ]

1

[]

0

null

[ "Bilateria" ]

[ 769 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4, 3 ]

4

true

Family

Glycogen synthase kinase-3 binding protein

GSK3-bd

9

IPR008015

8,015

GMP phosphodiesterase, delta subunit

PDED_dom

Domain

5,273

false

This entry represents a domain found in GMP-PDE delta subunit and related proteins.

[]

0

[ "PFAM" ]

[ "PF05351" ]

[ "GMP_PDE_delta" ]

[ 5273 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5624958", "R-BTA-9648002", "R-CEL-5624138", "R-CEL-9648002", "R-CFA-5624958", "R-CFA-9648002", "R-DME-9648002", "R-DRE-5624138", "R-HSA-5624138", "R-HSA-5624958", "R-HSA-9648002", "R-MMU-5624138", "R-MMU-5624958", "R-MMU-9648002" ]

[ "REACTOME:R-BTA-5624958", "REACTOME:R-BTA-9648002", "REACTOME:R-CEL-5624138", "REACTOME:R-CEL-9648002", "REACTOME:R-CFA-5624958", "REACTOME:R-CFA-9648002", "REACTOME:R-DME-9648002", "REACTOME:R-DRE-5624138", "REACTOME:R-HSA-5624138", "REACTOME:R-HSA-5624958", "REACTOME:R-HSA-9648002", "REACTOM...

14

[ "1ksg", "1ksh", "1ksj", "3gqq", "3rbq", "3t5g", "3t5i", "4goj", "4gok", "4jhp", "4jv6", "4jv8", "4jvb", "4jvf", "5e80", "5e8f", "5f2u", "5l7k", "5ml2", "5ml3", "5ml4", "5ml6", "5ml8", "5nal", "5t4x", "5tar", "5tb5", "5x72", "5x73", "5x74", "5yav", "5yaw"...

49

[ "PUB00010494" ]

[ "11980706" ]

[ "The complex of Arl2-GTP and PDE delta: from structure to function." ]

[ 2002 ]

1

[]

0

null

[ "Blautia caccae", "Eukaryota" ]

[ 1, 5272 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 9, 8, 15, 10, 13 ]

6

true

Domain

GMP phosphodiesterase, delta subunit

PDED_dom

1

IPR008016

8,016

Portal protein Gp10

Gp10

Family

197

false

This entry represents the upper collar protein (also known as portal protein Gp10) from various bacteriophage. The upper collar protein of Bacteriophage phi-29 is composed of twelve 36kDa subunits with 12-fold symmetry. It consists of two domains: an α-helical bundle domain and a β-barrel domain. This protein is locate...

[]

0

[ "PFAM" ]

[ "PF05352" ]

[ "Phage_connector" ]

[ 197 ]

1

[]

0

[ "1fou", "1h5w", "1ijg", "1jnb", "6iac", "6q3g", "6qx7", "6qyj", "6qym", "6qz9", "6qzf", "7pv2", "7pv4", "8egr" ]

14

[ "PUB00010495", "PUB00077561" ]

[ "9891587", "15886394" ]

[ "Tailed bacteriophages: the order caudovirales.", "Binding of pRNA to the N-terminal 14 amino acids of connector protein of bacteriophage phi29." ]

[ 1998, 2005 ]

2

[]

0

null

[ "Bacteria", "Ecdysozoa", "Viruses", "bioreactor metagenome" ]

[ 13, 4, 179, 1 ]

4

[]

0

true

Family

Portal protein Gp10

Gp10

8

IPR008017

8,017

Delta-hexatoxin

Family

24

false

Delta-hexatoxin (also known as delta-atracotoxin) is an arachnid toxin that produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels [ ]. Effects are an increase in resting tension, a muscle fasciculation and a decrease in indirect twitch tension. In vivo, ...

[ "GO:0019871", "GO:0005576" ]

[ "sodium channel inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PROSITE" ]

[ "PF05353", "PS60018" ]

[ "Atracotoxin", "DELTA_ACTX" ]

[ 24, 10 ]

2

[ "PROSITEDOC" ]

[ "PDOC60018" ]

[ "PROSITEDOC:PDOC60018" ]

1

[ "1qdp", "1vtx", "2roo" ]

3

[ "PUB00010496", "PUB00153368" ]

[ "9384567", "14596942" ]

[ "The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.", "Isolation of delta-missulenatoxin-Mb1a, the major vertebrate-active spider delta-toxin from the venom of Missulena bradleyi (Actinopodidae)." ]

[ 1997, 2003 ]

2

[]

0

null

[ "Avicularoidea" ]

[ 24 ]

1

[]

0

true

Family

Delta-hexatoxin

9

IPR008018

8,018

Bacteriophage tail attachment protein FII

Phage_tail_attach_FII

Family

2,744

false

The phage head-tail attachment protein is required for the joining of phage heads and tails at the last step of morphogenesis [ ]. FII is incorporated into the base vertex of DNA-filled heads to facilitate head-tail joining and may determine the specificity of tail attachment. There are 5-6 copies of protein FII per ma...

[ "GO:0019068" ]

[ "virion assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05354" ]

[ "Phage_attach" ]

[ 2744 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "1k0h", "2kx4", "8gtf", "8k37", "8xow", "8xpm", "8xqb" ]

7

[ "PUB00010497" ]

[ "12083526" ]

[ "The solution structure of the bacteriophage lambda head-tail joining protein, gpFII." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2675, 4, 49, 16 ]

4

[]

0

true

Family

Bacteriophage tail attachment protein FII

Phage_tail_attach_FII

6

IPR008019

8,019

Apolipoprotein C-II

Apo-CII

Family

433

false

Apolipoprotein CII (apoC-II) is a surface constituent of plasma lipoproteins and the activator for lipoprotein lipase (LPL). It is therefore central for lipid transport in blood. Lipoprotein lipase is a key enzyme in the regulation of triglyceride levels in human serum [ ]. It is the C-terminal helix of apoC-II that is...

[ "GO:0008047", "GO:0006629", "GO:0006869", "GO:0042627" ]

[ "enzyme activator activity", "lipid metabolic process", "lipid transport", "chylomicron" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05355", "PTHR16566" ]

[ "Apo-CII", "" ]

[ 428, 427 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8963888", "R-BTA-8963901", "R-BTA-8964058", "R-BTA-975634", "R-CFA-8963888", "R-CFA-8963901", "R-CFA-8964058", "R-CFA-975634", "R-HSA-8963888", "R-HSA-8963889", "R-HSA-8963901", "R-HSA-8964058", "R-HSA-9029569", "R-HSA-975634", "R-MMU-8963888", "R-MMU-8963901", "R-MMU-8964058"...

[ "REACTOME:R-BTA-8963888", "REACTOME:R-BTA-8963901", "REACTOME:R-BTA-8964058", "REACTOME:R-BTA-975634", "REACTOME:R-CFA-8963888", "REACTOME:R-CFA-8963901", "REACTOME:R-CFA-8964058", "REACTOME:R-CFA-975634", "REACTOME:R-HSA-8963888", "REACTOME:R-HSA-8963889", "REACTOME:R-HSA-8963901", "REACTOME:...

22

[ "1by6", "1i5j", "1o8t", "1soh" ]

4

[ "PUB00010498", "PUB00025907", "PUB00029348" ]

[ "10903476", "11331005", "12590574" ]

[ "Structure of a biologically active fragment of human serum apolipoprotein C-II in the presence of sodium dodecyl sulfate and dodecylphosphocholine.", "NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate.", "Global structure and dynamics of human apolipoprotein CII in complex wi...

[ 2000, 2001, 2003 ]

3

[]

0

null

[ "Bilateria" ]

[ 433 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 2, 2 ]

4

true

Family

Apolipoprotein C-II

Apo-CII

1

IPR008021

8,021

Attachment protein G3P, N-terminal

Attachment_G3P_N

Domain

79

false

The G3P protein (also known as attachment protein or coat protein A) of filamentous phage such as M13, phage fd and phage f1, is an essential coat protein for the infection of Escherichia coli. The G3P protein consists of three domains: two N-terminal domains (N1 and N2) with a similar β-barrel fold, and a C-terminal d...

[]

0

[ "PFAM" ]

[ "PF05357" ]

[ "Phage_Coat_A" ]

[ 79 ]

1

[]

0

[ "1fgp", "1g3p", "1tol", "2g3p", "2x9a", "2x9b", "3dgs", "3knq", "4eo1", "8b3o", "8ixk", "8jwx", "9g8e" ]

13

[ "PUB00010500", "PUB00033212", "PUB00033213" ]

[ "10329170", "9461080", "12767837" ]

[ "Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability.", "The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p.", "The folding mechanism of a two-domain protein: folding kinetics and ...

[ 1999, 1998, 2003 ]

3

[]

0

null

[ "Bacteria", "Ceraceosorus bombacis", "Inoviridae" ]

[ 59, 1, 19 ]

3

[]

0

true

Domain

Attachment protein G3P, N-terminal

Attachment_G3P_N

6

IPR008022

8,022

DicB

Family

240

false

DicB is part of the dic operon, which resides on cryptic prophage Kim. Under normal conditions, expression of dicB is actively repressed. When expression is induced, however, cell division rapidly ceases, and this division block is dependent on MinC with which it interacts [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF049927", "PF05358" ]

[ "CellDivInhibDicB", "DicB" ]

[ 219, 240 ]

2

[]

0

[]

0

[ "PUB00010501", "PUB00163086" ]

[ "12003935", "27466443" ]

[ "Targeting of (D)MinC/MinD and (D)MinC/DicB complexes to septal rings in Escherichia coli suggests a multistep mechanism for MinC-mediated destruction of nascent FtsZ rings.", "Characterization of DicB by partially masking its potent inhibitory activity of cell division." ]

[ 2002, 2016 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 240 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DicB

1

IPR008023

8,023

Protein of unknown function DUF748

DUF748

Family

6,296

false

This is a family of proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF05359" ]

[ "DUF748" ]

[ 6296 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6184, 16, 96 ]

3

[]

0

true

Family

Protein of unknown function DUF748

DUF748

6

IPR008024

8,024

YiaAB two helix

YiaAB

Domain

5,277

false

This domain consists of two transmembrane helices and a conserved linking section.

[]

0

[ "PFAM" ]

[ "PF05360" ]

[ "YiaAB" ]

[ 5277 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctHip2", "metagenomes" ]

[ 5259, 6, 1, 11 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

YiaAB two helix

YiaAB

3

IPR008025

8,025

CPI-17

Family

3,586

false

Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17 (also known a...

[ "GO:0042325", "GO:0005737" ]

[ "regulation of phosphorylation", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05361", "PTHR16188" ]

[ "PP1_inhibitor", "" ]

[ 3562, 3507 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5625740", "R-MMU-5625740", "R-RNO-5625740", "R-SSC-5625740" ]

[ "REACTOME:R-HSA-5625740", "REACTOME:R-MMU-5625740", "REACTOME:R-RNO-5625740", "REACTOME:R-SSC-5625740" ]

4

[ "1j2m", "1j2n", "1k5o", "2rlt" ]

4

[ "PUB00010502" ]

[ "11734001" ]

[ "Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3584, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 1, 12, 12, 22 ]

6

true

Family

CPI-17

9

IPR008026

8,026

Herpesvirus ICP47

Herpes_ICP47

Family

59

false

ICP47 (US12) is a key factor in the evasion of cellular immune response against Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)-infected cells. Specific inhibition of the transporter associated with antigen processing (TAP) by ICP47 prevents peptide transport into the endoplasmic reticulum and subsequent loa...

[ "GO:0052031" ]

[ "symbiont-mediated perturbation of host defense response" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05363" ]

[ "Herpes_US12" ]

[ 59 ]

1

[]

0

[ "1qlo", "5u1d" ]

2

[ "PUB00010503" ]

[ "10521276" ]

[ "Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy." ]

[ 1999 ]

1

[]

0

null

[ "Rhodospirillaceae", "Simplexvirus" ]

[ 2, 57 ]

2

[]

0

true

Family

Herpesvirus ICP47

Herpes_ICP47

8

IPR008027

8,027

Cytochrome b-c1 complex subunit 9

QCR9

Family

3,222

false

Cytochrome b-c1 complex subunit 9 (QCR9) is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. It may interact with cytochrome c1 [ , ]. QCR9 contains the single transmembrane helix structure.

[ "GO:0006122" ]

[ "mitochondrial electron transport, ubiquinol to cytochrome c" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05365", "PTHR12980" ]

[ "UCR_UQCRX_QCR9", "" ]

[ 3217, 2801 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-9865881", "R-DDI-611105", "R-DME-611105", "R-DME-9865881", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-MMU-9865881", "R-SCE-611105", "R-SCE-9865878", "R-SPO-611105" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9865881", "REACTOME:R-DDI-611105", "REACTOME:R-DME-611105", "REACTOME:R-DME-9865881", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9865881", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-9865881", "REACTOME:R-SCE-611105", "REACTOME:R-SCE-9865878", "REACTOME:R-SP...

12

[ "1bcc", "1be3", "1bgy", "1ezv", "1kb9", "1kyo", "1l0l", "1l0n", "1ntk", "1ntm", "1ntz", "1nu1", "1p84", "1pp9", "1ppj", "1qcr", "1sqb", "1sqp", "1sqq", "1sqv", "1sqx", "2a06", "2bcc", "2fyu", "2ibz", "2ybb", "3bcc", "3cwb", "3cx5", "3cxh", "3h1h", "3h1i"...

176

[ "PUB00014570", "PUB00063090" ]

[ "2174427", "1332881" ]

[ "Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4.", "Deletion of subunit 9 of the Saccharomyces cerevisiae cytoch...

[ 1990, 1992 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3222 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 4, 2, 2, 1, 3, 5, 1, 1, 9 ]

12

true

Family

Cytochrome b-c1 complex subunit 9

QCR9

2

IPR008028

8,028

Sarcolipin

Family

222

false

This entry represents Sarcolipin (SLN) and similar proteins from vertebrates. SLN is a short integral membrane protein that regulates Ca-ATPase activity in skeletal muscle [ ]. It has also been shown to amplify calcineurin signalling, and is a potential therapeutic target for the management of muscular dystrophy, as it...

[ "GO:0030234", "GO:0016020" ]

[ "enzyme regulator activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF05366", "cd20253" ]

[ "Sarcolipin", "Sarcolipin" ]

[ 222, 190 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5578775", "R-HSA-936837" ]

[ "REACTOME:R-HSA-5578775", "REACTOME:R-HSA-936837" ]

2

[ "1jdm", "3w5a", "4h1w" ]

3

[ "PUB00010505", "PUB00102247", "PUB00102248" ]

[ "11781085", "29051551", "30137316" ]

[ "Structure and orientation of sarcolipin in lipid environments.", "Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice.", "Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology." ]

[ 2002, 2017, 2018 ]

3

[]

0

null

[ "Euteleostomi" ]

[ 222 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1 ]

4

true

Family

Sarcolipin

9

IPR008029

8,029

Bacteriophage T7, Gp3, endodeoxynuclease I

Phage_T7_Gp3_endoDNaseI

Family

686

false

Endonuclease I ( ) is a junction-resolving enzyme encoded by bacteriophage T7, that selectively binds and cleaves four-way Holliday DNA junctions [ ]. The structure of the enzyme shows that it forms a symmetric homodimer arranged in two well-separated domains. Each domain, however, is composed of elements from both sub...

[ "GO:0008833", "GO:0015074", "GO:0016032" ]

[ "deoxyribonuclease IV (phage-T4-induced) activity", "DNA integration", "viral process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM", "CDD" ]

[ "PF05367", "cd22324" ]

[ "Phage_endo_I", "Endonuclease_I" ]

[ 685, 646 ]

2

[]

0

[ "1fzr", "1m0d", "1m0i", "2pfj", "3cae" ]

5

[ "PUB00010506", "PUB00010507" ]

[ "12093751", "11135673" ]

[ "Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I.", "Crystal structure of the Holliday junction resolving enzyme T7 endonuclease I." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 88, 2, 587, 9 ]

4

[]

0

true

Family

Bacteriophage T7, Gp3, endodeoxynuclease I

Phage_T7_Gp3_endoDNaseI

1

IPR008030

8,030

NmrA-like domain

NmrA-like

Domain

72,394

false

NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA [ ]. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may b...

[]

0

[ "PFAM" ]

[ "PF05368" ]

[ "NmrA" ]

[ 72394 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-70635", "R-HSA-70635", "R-MMU-611105", "R-MMU-6799198", "R-MMU-70635", "R-RNO-611105", "R-RNO-6799198" ]

[ "REACTOME:R-BTA-70635", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-70635", "REACTOME:R-RNO-611105", "REACTOME:R-RNO-6799198" ]

7

[ "1k6i", "1k6j", "1k6x", "1qyc", "1qyd", "1ti7", "1xgk", "2exx", "2gas", "2jl1", "2qw8", "2qx7", "2qys", "2qzz", "2r2g", "2r6j", "2vrb", "2vrc", "2vus", "2vut", "2vuu", "2wm3", "2wmd", "2zcu", "2zcv", "3c1o", "3c3x", "3dxf", "3e5m", "3i52", "3i5m", "3i6i"...

99

[ "PUB00010508", "PUB00030449", "PUB00049911", "PUB00094311" ]

[ "11726498", "13129921", "18602114", "18263583" ]

[ "The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.", "Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases.", "Structural a...

[ 2001, 2003, 2008, 2008 ]

4

[]

[ "IPR045312" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Klosneuvirinae", "metagenomes" ]

[ 196, 23449, 48632, 2, 115 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 49, 1, 6, 5, 12, 48, 9, 45 ]

8

true

Domain

NmrA-like domain

NmrA-like

5

IPR008031

8,031

Monomethylamine methyltransferase MtmB

MtmB_MeTrfase

Family

341

false

Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG [ ]. The structure of the enzyme reveals a homohexamer comprised of individual subunits with a TIM barrel fold. MtmB initiates the metabolism of monomethylamine ...

[ "GO:0008168", "GO:0032259" ]

[ "methyltransferase activity", "methylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05369" ]

[ "MtmB" ]

[ 341 ]

1

[ "EC", "METACYC" ]

[ "2.1.1.248", "PWY-5247" ]

[ "EC:2.1.1.248", "METACYC:PWY-5247" ]

2

[ "1l2q", "1nth", "1tv2", "1tv3", "1tv4" ]

5

[ "PUB00010606", "PUB00035327", "PUB00069753" ]

[ "12121639", "9642198", "9195968" ]

[ "Genetic code: introducing pyrrolysine.", "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.", "Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri." ]

[ 2002, 1998, 1997 ]

3

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 189, 95, 57 ]

3

[]

0

true

Family

Monomethylamine methyltransferase MtmB

MtmB_MeTrfase

6

IPR008032

8,032

Protein of unknown function DUF749

DUF749

Family

87

false

This is a family of unknown function found in archaebacterial proteins. The family has been solved via structural genomics techniques and comprises of segregated helical and anti-parallel β sheet regions. It is a putative metal-binding protein.

[]

0

[ "PFAM" ]

[ "PF05370" ]

[ "DUF749" ]

[ 87 ]

1

[]

0

[ "1iqo", "1iqs" ]

2

[]

0

[]

[ "IPR016458" ]

0

1

0

[ "Methanomada group", "ecological metagenomes" ]

[ 85, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF749

DUF749

9

IPR008034

8,034

Delta-hemolysin

Delta_lysin

Family

48

false

Delta-hemolysin (also known as Delta-lysin) is a 26 amino acid, hemolytic peptide toxin secreted by Staphylococcus aureus. It is thought that delta-toxin forms an amphipathic helix upon binding to lipid bilayers [ ]. It possesses hemolytic/lytic and antimicrobial activity [ ]. It may slightly perturb the membrane or le...

[ "GO:0019836", "GO:0005576" ]

[ "symbiont-mediated hemolysis of host erythrocyte", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05372" ]

[ "Delta_lysin" ]

[ 48 ]

1

[]

0

[ "1dtc", "2dtb", "2kam" ]

3

[ "PUB00010512", "PUB00070720" ]

[ "12206677", "19150639" ]

[ "Mechanism and kinetics of delta-lysin interaction with phospholipid vesicles.", "delta-hemolysin, an update on a membrane-interacting peptide." ]

[ 2002, 2009 ]

2

[]

0

null

[ "Bacteria" ]

[ 48 ]

1

[]

0

true

Family

Delta-hemolysin

Delta_lysin

6

IPR008035

8,035

L-proline 3-hydroxylase, C-terminal

Pro_3_hydrox_C

Domain

139

false

Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure contains conserved motifs present in other 2-OG oxyg...

[ "GO:0016706" ]

[ "2-oxoglutarate-dependent dioxygenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05373" ]

[ "Pro_3_hydrox_C" ]

[ 139 ]

1

[]

0

[ "1e5r", "1e5s", "4p7w", "4p7x" ]

4

[ "PUB00020183" ]

[ "11737217" ]

[ "Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria" ]

[ 139 ]

1

[]

0

true

Domain

L-proline 3-hydroxylase, C-terminal

Pro_3_hydrox_C

9

IPR008036

8,036

Conotoxin, mu-type

Conotoxin_mu-typ

Family

21

false

This entry represents Mu-type conotoxins. Cone snail toxins, conotoxins, are small peptides with disulphide connectivity, that target ion-channels or G-protein coupled receptors. Based on the number and pattern of disulphide bonds and biological activities, conotoxins can be classified into several families [ ]. Omega,...

[ "GO:0019871", "GO:0005576" ]

[ "sodium channel inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PROSITE" ]

[ "PF05374", "PS60013" ]

[ "Mu-conotoxin", "MU_CONOTOXIN" ]

[ 10, 15 ]

2

[ "PROSITEDOC" ]

[ "PDOC60004" ]

[ "PROSITEDOC:PDOC60004" ]

1

[ "1gib", "1q2j", "1r9i", "1tcg", "1tch", "1tcj", "1tck", "2yen", "6mjd", "6x8r" ]

10

[ "PUB00010513", "PUB00010514", "PUB00016617", "PUB00016622", "PUB00017021", "PUB00096639", "PUB00096640", "PUB00099605" ]

[ "12006587", "12193600", "11478951", "10988292", "2410412", "21652775", "30360356", "33023152" ]

[ "Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels.", "Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.", "Cone venom--from accidental stings to deliberate injection.", "lambda-conotoxins, a n...

[ 2002, 2002, 2001, 2000, 1985, 2011, 2018, 2020 ]

8

[]

0

null

[ "Bacillati", "Conus" ]

[ 3, 18 ]

2

[]

0

true

Family

Conotoxin, mu-type

Conotoxin_mu-typ

6

IPR008037

8,037

Pacifastin domain

Pacifastin_dom

Domain

1,455

false

Proteins containing this domain are proteinase inhibitors belonging to MEROPS inhibitor family I19 (clan IW) and sharing a pacifastin domain of ~35 residues, which contains a characteristic pattern of six conserved cysteine residues (C-x(9,12)-C-N-x-C-x-C-x(2,3)-G-x(3,6)-C-T-x(3)- C). The pacifastin domain consists of ...

[ "GO:0030414" ]

[ "peptidase inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05375", "PS51446" ]

[ "Pacifastin_I", "PACIFASTIN" ]

[ 1381, 936 ]

2

[]

0

[ "1gl0", "1gl1", "1kgm", "1kio", "1kj0", "1pmc", "1wo9", "2f91", "2vu8", "2xtt", "3tvj", "4djz", "7sao", "7sap", "7sgq", "7slt", "7snc", "7snd" ]

18

[ "PUB00001409", "PUB00010515", "PUB00011845", "PUB00011846", "PUB00011847", "PUB00014299", "PUB00014300", "PUB00014301", "PUB00049902", "PUB00052614" ]

[ "1740125", "9192625", "11856311", "11997226", "11495915", "1472051", "10696590", "9475173", "19020355", "15631618" ]

[ "Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide.", "Pacifastin, a novel 155-kDa heterodimeric proteinase inhibitor containing a unique transferrin chain.", "Comparative structure analysis of proteinase inhibitors from t...

[ 1992, 1997, 2002, 2002, 2001, 1992, 2000, 1998, 2008, 2005 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "marine metagenome" ]

[ 35, 1416, 3, 1 ]

4

[ "Danio rerio" ]

[ 3 ]

1

true

Domain

Pacifastin domain

Pacifastin_dom

3

IPR008040

8,040

Hydantoinase/oxoprolinase, N-terminal

Hydant_A_N

Domain

28,107

false

This domain is found at the N terminus of the hydantoinase/oxoprolinase family.

[]

0

[ "PFAM" ]

[ "PF05378" ]

[ "Hydant_A_N" ]

[ 28107 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1664", "R-DDI-174403", "R-HSA-174403", "R-HSA-5578998", "R-MMU-174403", "R-RNO-174403", "R-SCE-174403", "R-SPO-174403" ]

[ "GP:GenProp1664", "REACTOME:R-DDI-174403", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-5578998", "REACTOME:R-MMU-174403", "REACTOME:R-RNO-174403", "REACTOME:R-SCE-174403", "REACTOME:R-SPO-174403" ]

8

[ "5l9w", "5m45", "5svb", "5svc", "6yra", "9h03" ]

6

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1217, 17665, 8759, 466 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 2, 3, 5, 2, 3, 6, 1, 2, 2 ]

12

true

Domain

Hydantoinase/oxoprolinase, N-terminal

Hydant_A_N

1

IPR008042

8,042

Retrotransposon Pao-like, RNAseH-like domain

Retrotrans_Pao_RNase-like

Domain

26,032

false

This domain is found in Pao retrotransposons and retroviruses. It may adopt a RNaseH-like fold.

[]

0

[ "PFAM" ]

[ "PF05380" ]

[ "Peptidase_A17" ]

[ 26032 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 13, 26016, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster" ]

[ 1, 155, 6 ]

3

true

Domain

Retrotransposon Pao-like, RNAseH-like domain

Retrotrans_Pao_RNase-like

5

IPR008044

8,044

Bacteriophage lysin

Phage_lysin

Domain

1,054

false

This entry is represents bacteriophage lysins (Cell wall hydrolase; ). The Pal protein from the pneumococcal bacteriophage Dp-1 ( ) has been shown to be an N-acetylmuramoyl-L-alanine amidase [ ]. According to the known modular structure of this and other peptidoglycan hydrolases from the pneumococcal system, the active...

[]

0

[ "PFAM" ]

[ "PF05382" ]

[ "Amidase_5" ]

[ 1054 ]

1

[]

0

[ "8tw1" ]

1

[ "PUB00004669", "PUB00010518", "PUB00010519" ]

[ "3422470", "6146601", "9379901" ]

[ "Molecular evolution of lytic enzymes of Streptococcus pneumoniae and its bacteriophages.", "Biochemical characterization of a murein hydrolase induced by bacteriophage Dp-1 in Streptococcus pneumoniae: comparative study between bacteriophage-associated lysin and the host amidase.", "The lytic enzyme of the pne...

[ 1988, 1984, 1997 ]

3

[]

0

null

[ "Bacteria", "Viruses" ]

[ 852, 202 ]

2

[]

0

true

Domain

Bacteriophage lysin

Phage_lysin

3

IPR008045

8,045

DNA replication licensing factor Mcm2

MCM2

Family

4,644

false

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm2 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is pa...

[ "GO:0003677", "GO:0005524", "GO:0006270", "GO:0005634", "GO:0042555" ]

[ "DNA binding", "ATP binding", "DNA replication initiation", "nucleus", "MCM complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01658" ]

[ "MCMPROTEIN2" ]

[ 4644 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-HSA-9825895", "R-MMU-176187", "R-MMU-68867", "R-MMU-68949", "R-MMU-68962", "R-MMU-69052", "R-SCE-...

[ "EC:3.6.4.12", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-176974", "REACTOME:R-HSA-68867", "REACTOME:R-HSA-68949", "REACTOME:R-HSA-68962", "REACTOME:R-HSA-69052", "REACTOME:...

31

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo", "7plo"...

83

[ "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "19896182", "19910535", "22841721", "17506634" ]

[ "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.", "Control over DNA replication in time and space.", "Structure and mechanism of helicases and nucleic...

[ 2009, 2009, 2012, 2007 ]

4

[ "IPR031327" ]

[]

1

0

1

[ "Eukaryota", "Thermococcus" ]

[ 4642, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 5, 3, 1, 1, 2, 1, 1, 12 ]

12

true

Family

DNA replication licensing factor Mcm2

MCM2

9

IPR008046

8,046

DNA replication licensing factor Mcm3

Mcm3

Family

5,065

false

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm3 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is pa...

[ "GO:0003677", "GO:0005524", "GO:0006270", "GO:0042555" ]

[ "DNA binding", "ATP binding", "DNA replication initiation", "MCM complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01659" ]

[ "MCMPROTEIN3" ]

[ 5065 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-BTA-176187", "R-BTA-68867", "R-BTA-68949", "R-BTA-68962", "R-BTA-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-MMU-176187", "R-MMU-6...

[ "EC:3.6.4.12", "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68867", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-BTA-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:...

35

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgc", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo"...

84

[ "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "19896182", "19910535", "22841721", "17506634" ]

[ "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.", "Control over DNA replication in time and space.", "Structure and mechanism of helicases and nucleic...

[ 2009, 2009, 2012, 2007 ]

4

[ "IPR031327" ]

[]

1

0

1

[ "Eukaryota", "Thermoproteota archaeon" ]

[ 5064, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 3, 2, 10, 4, 1, 2, 2, 1, 1, 20 ]

12

true

Family

DNA replication licensing factor Mcm3

Mcm3

5

IPR008047

8,047

DNA replication licensing factor MCM4

MCM_4

Family

5,023

false

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm3 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is pa...

[ "GO:0003677", "GO:0003678", "GO:0005524", "GO:0006270", "GO:0042555" ]

[ "DNA binding", "DNA helicase activity", "ATP binding", "DNA replication initiation", "MCM complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01660" ]

[ "MCMPROTEIN4" ]

[ 5023 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-CEL-68867", "R-CEL-68949", "R-CEL-68962", "R-CEL-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-MMU-176187", "R-MMU-68867", "R-MMU-68...

[ "EC:3.6.4.12", "REACTOME:R-CEL-68867", "REACTOME:R-CEL-68949", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-176974", "REACTOME:...

34

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo", "7plo"...

83

[ "PUB00010306", "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "8901561", "19896182", "19910535", "22841721", "17506634" ]

[ "Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.", "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA re...

[ 1996, 2009, 2009, 2012, 2007 ]

5

[ "IPR031327" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 171, 4850, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 3, 9, 8, 1, 2, 3, 1, 1, 10 ]

12

true

Family

DNA replication licensing factor MCM4

MCM_4

6

IPR008048

8,048

DNA replication licensing factor Mcm5

MCM5

Family

4,588

false

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm5 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is pa...

[ "GO:0003688", "GO:0005524", "GO:0006270", "GO:0005634", "GO:0042555" ]

[ "DNA replication origin binding", "ATP binding", "DNA replication initiation", "nucleus", "MCM complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01661" ]

[ "MCMPROTEIN5" ]

[ 4588 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-CEL-68867", "R-CEL-68949", "R-CEL-68962", "R-CEL-69052", "R-DDI-68867", "R-DDI-68962", "R-DDI-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-690...

[ "EC:3.6.4.12", "REACTOME:R-CEL-68867", "REACTOME:R-CEL-68949", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69052", "REACTOME:R-DDI-68867", "REACTOME:R-DDI-68962", "REACTOME:R-DDI-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-...

38

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo", "7plo"...

82

[ "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "19896182", "19910535", "22841721", "17506634" ]

[ "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.", "Control over DNA replication in time and space.", "Structure and mechanism of helicases and nucleic...

[ 2009, 2009, 2012, 2007 ]

4

[ "IPR031327" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4588 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 10, 3, 1, 1, 5, 1, 1, 17 ]

12

true

Family

DNA replication licensing factor Mcm5

MCM5

6

IPR008049

8,049

DNA replication licensing factor Mcm6

MCM6

Family

4,591

false

In eukaryotes, Mcm6 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replicatio...

[ "GO:0003677", "GO:0003678", "GO:0005524", "GO:0006270", "GO:0005634", "GO:0042555" ]

[ "DNA binding", "DNA helicase activity", "ATP binding", "DNA replication initiation", "nucleus", "MCM complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

6

[ "PRINTS" ]

[ "PR01662" ]

[ "MCMPROTEIN6" ]

[ 4591 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-CEL-68867", "R-CEL-68949", "R-CEL-68962", "R-CEL-69052", "R-DDI-68867", "R-DDI-68962", "R-DDI-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-690...

[ "EC:3.6.4.12", "REACTOME:R-CEL-68867", "REACTOME:R-CEL-68949", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69052", "REACTOME:R-DDI-68867", "REACTOME:R-DDI-68962", "REACTOME:R-DDI-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-...

37

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo", "7plo"...

83

[ "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "19896182", "19910535", "22841721", "17506634" ]

[ "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.", "Control over DNA replication in time and space.", "Structure and mechanism of helicases and nucleic...

[ 2009, 2009, 2012, 2007 ]

4

[ "IPR031327" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4591 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 2, 2, 4, 1, 1, 7, 1, 1, 8 ]

12

true

Family

DNA replication licensing factor Mcm6

MCM6

1

IPR008050

8,050

DNA replication licensing factor Mcm7

MCM7

Family

7,494

false

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm7 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [ ]. MCM2-7 complex is pa...

[ "GO:0003677", "GO:0003678", "GO:0005524", "GO:0006270", "GO:0042555" ]

[ "DNA binding", "DNA helicase activity", "ATP binding", "DNA replication initiation", "MCM complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PRINTS", "CDD" ]

[ "PR01663", "cd17758" ]

[ "MCMPROTEIN7", "MCM7" ]

[ 7288, 3546 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-BTA-176187", "R-BTA-68867", "R-BTA-68949", "R-BTA-68962", "R-BTA-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-MMU-176187", "R-MMU-6...

[ "EC:3.6.4.12", "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68867", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-BTA-69052", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:...

35

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgc", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo"...

84

[ "PUB00010327", "PUB00010416", "PUB00063043", "PUB00063044", "PUB00063046", "PUB00063047" ]

[ "9566894", "11861392", "19896182", "19910535", "22841721", "17506634" ]

[ "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.", "Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.", "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin...

[ 1998, 2002, 2009, 2009, 2012, 2007 ]

6

[ "IPR031327" ]

[]

1

0

1

[ "Eukaryota" ]

[ 7494 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 9, 7, 1, 1, 5, 1, 1, 19 ]

12

true

Family

DNA replication licensing factor Mcm7

MCM7

9

IPR008052

8,052

Voltage gated sodium channel, alpha-4 subunit, mammalian

Na_channel_a4su_mammal

Family

211

false

Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in most electrically excitable cells [ ]. They may exist in 3 states [ ]: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated s...

[ "GO:0005248", "GO:0006814", "GO:0001518" ]

[ "voltage-gated sodium channel activity", "sodium ion transport", "voltage-gated sodium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01665" ]

[ "NACHANNEL4" ]

[ 211 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892" ]

2

[ "6agf" ]

1

[ "PUB00000213", "PUB00003989", "PUB00004785", "PUB00069395", "PUB00069664", "PUB00069665", "PUB00069666", "PUB00069667", "PUB00069668", "PUB00069669", "PUB00096460", "PUB00096461" ]

[ "1323284", "6209577", "1317577", "16919992", "10369308", "19118277", "11591859", "18046642", "20076800", "12766226", "21947499", "27143702" ]

[ "Proposed tertiary structure of the sodium channel.", "Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.", "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.", "Neuronal voltage-gated s...

[ 1992, 1984, 1992, 2006, 1999, 2009, 2001, 2008, 2009, 2003, 2012, 2016 ]

12

[ "IPR001696" ]

[]

1

0

1

[ "Mammalia" ]

[ 211 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3 ]

3

true

Family

Voltage gated sodium channel, alpha-4 subunit, mammalian

Na_channel_a4su_mammal

3

IPR008053

8,053

Voltage gated sodium channel, alpha-5 subunit

Na_channel_a5su

Family

1,226

false

Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in most electrically excitable cells [ ]. They may exist in 3 states [ ]: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated s...

[ "GO:0005248", "GO:0006814", "GO:0001518" ]

[ "voltage-gated sodium channel activity", "sodium ion transport", "voltage-gated sodium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01666" ]

[ "NACHANNEL5" ]

[ 1226 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892" ]

2

[ "6lqa", "7dtc", "8vyj", "8vyk", "9ith" ]

5

[ "PUB00000213", "PUB00003989", "PUB00004785", "PUB00010544", "PUB00010545", "PUB00010546", "PUB00096460", "PUB00096461" ]

[ "1323284", "6209577", "1317577", "7889574", "10358800", "10471492", "21947499", "27143702" ]

[ "Proposed tertiary structure of the sodium channel.", "Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.", "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.", "SCN5A mutations associat...

[ 1992, 1984, 1992, 1995, 1999, 1999, 2012, 2016 ]

8

[ "IPR001696" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 1226 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 5, 8 ]

3

true

Family

Voltage gated sodium channel, alpha-5 subunit

Na_channel_a5su

1

IPR008054

8,054

Voltage gated sodium channel, alpha-8 subunit

Na_channel_a8su

Family

1,759

false

Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in most electrically excitable cells [ ]. They may exist in 3 states [ ]: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated s...

[ "GO:0005248", "GO:0006814", "GO:0001518" ]

[ "voltage-gated sodium channel activity", "sodium ion transport", "voltage-gated sodium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01667" ]

[ "NACHANNEL8" ]

[ 1759 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892" ]

2

[ "8fhd", "8gz1", "8gz2", "9dk5" ]

4

[ "PUB00000213", "PUB00003989", "PUB00004785", "PUB00010547", "PUB00010548", "PUB00096460", "PUB00096461", "PUB00100435", "PUB00100436", "PUB00100437" ]

[ "1323284", "6209577", "1317577", "9192691", "9698304", "21947499", "27143702", "26677014", "8815882", "25725044" ]

[ "Proposed tertiary structure of the sodium channel.", "Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.", "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.", "Molecular characterizati...

[ 1992, 1984, 1992, 1997, 1998, 2012, 2016, 2016, 1996, 2015 ]

10

[ "IPR001696" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1759 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 6, 8, 8 ]

4

true

Family

Voltage gated sodium channel, alpha-8 subunit

Na_channel_a8su

1

IPR008055

8,055

Neurotensin/neuromedin N

NeurotensiN

Family

873

false

Neurotensin is a 13-residue peptide transmitter, sharing significant similarity in its 6 C-terminal amino acid residues with several other neuropeptides, including neuromedin N (which is derived from the same precursor). This C-terminal region is responsible for the full biological activity, the N-terminal portion havi...

[ "GO:0005184", "GO:0005576" ]

[ "neuropeptide hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF07421", "PR01668", "PTHR15356" ]

[ "Pro-NT_NN", "NEUROTENSIN", "" ]

[ 872, 761, 871 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-375276", "R-BTA-416476", "R-CFA-375276", "R-CFA-416476", "R-HSA-375276", "R-HSA-416476", "R-MMU-375276", "R-MMU-416476", "R-RNO-375276", "R-RNO-416476" ]

[ "REACTOME:R-BTA-375276", "REACTOME:R-BTA-416476", "REACTOME:R-CFA-375276", "REACTOME:R-CFA-416476", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476" ]

10

[]

0

[ "PUB00010549" ]

[ "11811984" ]

[ "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity." ]

[ 2002 ]

1

[]

0

null

[ "Bilateria" ]

[ 873 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 3 ]

4

true

Family

Neurotensin/neuromedin N

NeurotensiN

9

IPR008056

8,056

Tapasin

Family

765

false

Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8 T cells. The majority of peptides found associated with class I molecules are derived from nuclear and cytosolic proteins, and they are generated largely by the proteasome complex. These peptides are transported from cytosol into...

[ "GO:0019885", "GO:0016020" ]

[ "antigen processing and presentation of endogenous peptide antigen via MHC class I", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01669" ]

[ "TAPASIN" ]

[ 765 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-983170", "R-HSA-1236974", "R-HSA-983170", "R-MMU-1236974", "R-MMU-983170" ]

[ "REACTOME:R-CFA-983170", "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-983170", "REACTOME:R-MMU-1236974", "REACTOME:R-MMU-983170" ]

5

[ "3f8u", "6eny", "7qng", "7qpd", "7tue", "7tuf", "7tug" ]

7

[ "PUB00010318", "PUB00010342", "PUB00010346", "PUB00010359", "PUB00010594" ]

[ "9271576", "10085102", "10382748", "10636848", "9238042" ]

[ "A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.", "Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing.", "The N-terminal region of tapasin is required t...

[ 1997, 1999, 1999, 2000, 1997 ]

5

[]

0

null

[ "Gnathostomata" ]

[ 765 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 15, 15, 6 ]

4

true

Family

Tapasin

2

IPR008057

8,057

Gamma-aminobutyric-acid A receptor, Rho

GABAAa_rho_rcpt

Family

1,032

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01670" ]

[ "GABAARRHO" ]

[ 1032 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977443", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-BTA-977443", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[ "8op9", "8oq6", "8oq7", "8oq8", "8oqa", "8rh4", "8rh7", "8rh8", "8rh9", "8rhg", "9frb", "9fre", "9frf", "9frg", "9frh", "9fri", "9g55", "9g57", "9g5q", "9g5r", "9g60", "9g62", "9g70", "9g78", "9g7a", "9g7b" ]

26

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010279", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "6097844", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1984, 1999, 2008, 2004, 2008, 2004 ]

14

[ "IPR006028" ]

[ "IPR008058", "IPR008059" ]

1

2

0

[ "Euteleostomi" ]

[ 1032 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 3, 6 ]

4

true

Family

Gamma-aminobutyric-acid A receptor, Rho

GABAAa_rho_rcpt

7

IPR008058

8,058

Gamma-aminobutyric-acid A receptor, Rho1

GABAAa_rho1_rcpt

Family

513

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01671" ]

[ "GABAARRHO1" ]

[ 513 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

3

[ "8op9", "8oq6", "8oq7", "8oq8", "8oqa", "8rh4", "8rh7", "8rh8", "8rh9", "8rhg", "9frb", "9fre", "9frf", "9frg", "9frh", "9fri", "9g55", "9g57", "9g5q", "9g5r", "9g60", "9g62", "9g70", "9g78", "9g7a", "9g7b" ]

26

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010279", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "6097844", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1984, 1999, 2008, 2004, 2008, 2004 ]

14

[ "IPR008057" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 513 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, Rho1

GABAAa_rho1_rcpt

2

IPR008059

8,059

Gamma-aminobutyric-acid A receptor, Rho2

GABAAa_rho2_rcpt

Family

673

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01672" ]

[ "GABAARRHO2" ]

[ 673 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977443", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-BTA-977443", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010279", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "6097844", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1984, 1999, 2008, 2004, 2008, 2004 ]

14

[ "IPR008057" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 673 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 2, 6 ]

4

true

Family

Gamma-aminobutyric-acid A receptor, Rho2

GABAAa_rho2_rcpt

4

IPR008060

8,060

Glycine receptor beta

Glycine_rcpt_B

Family

1,179

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0016934", "GO:0006821", "GO:0016020", "GO:0045211" ]

[ "extracellularly glycine-gated chloride channel activity", "chloride transport", "membrane", "postsynaptic membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01677" ]

[ "GLYRBETA" ]

[ 1179 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-112314", "R-HSA-112314", "R-MMU-112314", "R-RNO-112314" ]

[ "REACTOME:R-BTA-112314", "REACTOME:R-HSA-112314", "REACTOME:R-MMU-112314", "REACTOME:R-RNO-112314" ]

4

[ "7mly", "7tu9", "7tvi", "8fe1" ]

4

[ "PUB00000213", "PUB00002675", "PUB00003455", "PUB00010340", "PUB00010348", "PUB00010386", "PUB00010388", "PUB00010391", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1323284", "1721053", "1846404", "10026168", "10414351", "11358478", "11396606", "11437237", "18446614", "15383648", "18760291", "15165736" ]

[ "Proposed tertiary structure of the sodium channel.", "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "Structural features of the ligand-binding ...

[ 1992, 1991, 1991, 1999, 1999, 2001, 2001, 2001, 2008, 2004, 2008, 2004 ]

12

[ "IPR006201" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1179 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 1, 3, 3 ]

4

true

Family

Glycine receptor beta

Glycine_rcpt_B

7

IPR008061

8,061

Potassium channel, inwardly rectifying, Kir5

K_chnl_inward-rec_Kir5

Family

644

false

Inwardly-rectifying potassium channels (Kir) are the principal class of two-TM domain potassium channels. They are characterised by the property of inward-rectification, which is described as the ability to allow large inward currents and smaller outward currents. Inwardly rectifying potassium channels (Kir) are respon...

[ "GO:0005242", "GO:0006813", "GO:0016020" ]

[ "inward rectifier potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01678" ]

[ "KIR5CHANNEL" ]

[ 644 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1296041", "R-HSA-1296067", "R-HSA-997272", "R-MMU-1296041", "R-MMU-1296067", "R-MMU-997272", "R-RNO-1296041", "R-RNO-1296067", "R-RNO-997272" ]

[ "REACTOME:R-HSA-1296041", "REACTOME:R-HSA-1296067", "REACTOME:R-HSA-997272", "REACTOME:R-MMU-1296041", "REACTOME:R-MMU-1296067", "REACTOME:R-MMU-997272", "REACTOME:R-RNO-1296041", "REACTOME:R-RNO-1296067", "REACTOME:R-RNO-997272" ]

9

[]

0

[ "PUB00001055", "PUB00001069", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00009378", "PUB00009410", "PUB00009411" ]

[ "1772658", "7580148", "1879548", "1373731", "2448635", "2451788", "2555158", "11178249", "10102275", "10449331" ]

[ "The molecular biology of K+ channels.", "The inward rectifier potassium channel family.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced ...

[ 1991, 1995, 1991, 1992, 1988, 1988, 1989, 2000, 1999, 1999 ]

10

[ "IPR016449" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 644 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 4, 8 ]

3

true

Family

Potassium channel, inwardly rectifying, Kir5

K_chnl_inward-rec_Kir5

6

IPR008062

8,062

Inward rectifier potassium channel 13

KCNJ13

Family

610

false

Inward rectifier potassium channels are characterised by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more posi...

[ "GO:0005242", "GO:0006813", "GO:0016020" ]

[ "inward rectifier potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01679" ]

[ "KIR7CHANNEL" ]

[ 610 ]

1

[]

0

[]

0

[ "PUB00068055", "PUB00068056" ]

[ "18179896", "21763485" ]

[ "Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration.", "Recessive mutations in KCNJ13, encoding an inwardly rectifying potassium channel subunit, cause leber congenital amaurosis." ]

[ 2008, 2011 ]

2

[ "IPR016449" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 610 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 5 ]

3

true

Family

Inward rectifier potassium channel 13

KCNJ13

8

IPR008063

8,063

Fas receptor

Fas_rcpt

Family

2,335

false

Like all apoptotic cell death, T cell receptor (TCR)-mediated death can be divided into two phases: an inductive phase and an effector phase. The effector phase includes a sequence of steps that are common to apoptosis in many cell types, which, if not interrupted, will lead to cell death. The induction phase, which of...

[ "GO:0004888", "GO:0006915", "GO:0006955", "GO:0007165", "GO:0016020" ]

[ "transmembrane signaling receptor activity", "apoptotic process", "immune response", "signal transduction", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01680" ]

[ "TNFACTORR6" ]

[ 2335 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-140534", "R-HSA-3371378", "R-HSA-5213460", "R-HSA-5218900", "R-HSA-6803211", "R-HSA-69416", "R-HSA-75157", "R-MMU-3371378", "R-MMU-5218900", "R-MMU-69416", "R-MMU-75157", "R-RNO-3371378", "R-RNO-5218900", "R-RNO-69416", "R-RNO-75157", "R-SSC-3371378", "R-SSC-5218900", "R-SSC...

[ "REACTOME:R-HSA-140534", "REACTOME:R-HSA-3371378", "REACTOME:R-HSA-5213460", "REACTOME:R-HSA-5218900", "REACTOME:R-HSA-6803211", "REACTOME:R-HSA-69416", "REACTOME:R-HSA-75157", "REACTOME:R-MMU-3371378", "REACTOME:R-MMU-5218900", "REACTOME:R-MMU-69416", "REACTOME:R-MMU-75157", "REACTOME:R-RNO-3...

19

[ "3thm", "3tje", "4mxw", "5tl5", "5tlj", "5tlk", "7kx0", "8ds5" ]

8

[ "PUB00010387", "PUB00010403" ]

[ "11391000", "11741599" ]

[ "CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.", "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Bilateria", "Nucleocytoviricota" ]

[ 2332, 3 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 19, 3, 8 ]

4

true

Family

Fas receptor

Fas_rcpt

6

IPR008065

8,065

Pro-FMRFamide-related neuropeptide FF

NPFF

Family

409

false

Neuropeptide FF (together with neuropeptides AF and SF, which are derived from the same precursor) belongs to a family of neuropeptides containing an RF-amide motif at their C-termini [ ]. Neuropeptide FF is found at high concentrations in the posterior pituitary, spinal cord, hypothalamus and medulla, and is believed ...

[ "GO:0005102", "GO:0005184" ]

[ "signaling receptor binding", "neuropeptide hormone activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PIRSF", "PRINTS", "PANTHER" ]

[ "PF15085", "PIRSF038092", "PR01682", "PTHR15044" ]

[ "NPFF", "FMRFamid-rel_pep_precur", "FMRFAMIDEPEP", "" ]

[ 401, 219, 275, 390 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-389397", "R-BTA-416476", "R-HSA-389397", "R-HSA-416476", "R-MMU-389397", "R-MMU-416476", "R-RNO-389397", "R-RNO-416476" ]

[ "REACTOME:R-BTA-389397", "REACTOME:R-BTA-416476", "REACTOME:R-HSA-389397", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-389397", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-389397", "REACTOME:R-RNO-416476" ]

8

[]

0

[ "PUB00007775" ]

[ "11325803" ]

[ "Functional characterization of a human receptor for neuropeptide FF and related peptides." ]

[ 2001 ]

1

[]

0

null

[ "Vertebrata" ]

[ 409 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 2, 2 ]

4

true

Family

Pro-FMRFamide-related neuropeptide FF

NPFF

6

IPR008066

8,066

Cytochrome P450, E-class, group I, CYP1

Cyt_P450_E_grp-I_CYP1

Family

2,377

false

Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty ac...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01683" ]

[ "EP450ICYP1A" ]

[ 2377 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REAC...

[ "1.14.14.1", "PWY-5451", "PWY-5665", "PWY-6398", "PWY-6992", "PWY-7466", "R-HSA-156581", "R-HSA-1989781", "R-HSA-211957", "R-HSA-211981", "R-HSA-2142670", "R-HSA-2142816", "R-HSA-5423646", "R-HSA-9018681", "R-HSA-9027307", "R-MMU-156581", "R-MMU-211957", "R-MMU-211981", "R-MMU-21...

[ "EC:1.14.14.1", "METACYC:PWY-5451", "METACYC:PWY-5665", "METACYC:PWY-6398", "METACYC:PWY-6992", "METACYC:PWY-7466", "REACTOME:R-HSA-156581", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-211957", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-2142670", "REACTOME:R-HSA-2142816", "REACTOME:R-HSA-5423646...

31

[ "2hi4", "4i8v", "6dwm", "6dwn", "6o5y", "6udl", "6udm" ]

7

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033973", "PUB00033974", "PUB00033983" ]

[ "16042601", "17023115", "15128046", "8637843", "16112414", "16922636", "16485905" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 2005, 2005, 2006 ]

7

[ "IPR002401" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2377 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 10, 4, 6 ]

4

true

Family

Cytochrome P450, E-class, group I, CYP1

Cyt_P450_E_grp-I_CYP1

9

IPR008067

8,067

Cytochrome P450, E-class, group I, CYP2A-like

Cyt_P450_E_grp-I_CYP2A-like

Family

2,363

false

Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty ac...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01684" ]

[ "EP450ICYP2A" ]

[ 2363 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.14.1", "PWY-5451", "PWY-5665", "PWY-6398", "PWY-6992", "PWY-7466", "R-HSA-211935", "R-HSA-211958", "R-HSA-211981", "R-HSA-211999", "R-HSA-5423646", "R-MMU-211935", "R-MMU-211958", "R-MMU-211981", "R-MMU-211999", "R-MMU-5423646", "R-RNO-211935", "R-RNO-211981", "R-RNO-211999...

[ "EC:1.14.14.1", "METACYC:PWY-5451", "METACYC:PWY-5665", "METACYC:PWY-6398", "METACYC:PWY-6992", "METACYC:PWY-7466", "REACTOME:R-HSA-211935", "REACTOME:R-HSA-211958", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-211999", "REACTOME:R-HSA-5423646", "REACTOME:R-MMU-211935", "REACTOME:R-MMU-211958", ...

20

[ "1z10", "1z11", "2fdu", "2fdv", "2fdw", "2fdy", "2p85", "2pg5", "2pg6", "2pg7", "3ebs", "3t3q", "3t3r", "3t3s", "4ejg", "4ejh", "4eji", "4ejj", "4rui" ]

19

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033975" ]

[ "16042601", "17023115", "15128046", "8637843", "16635107" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 2006 ]

5

[ "IPR002401" ]

[]

1

0

1

[ "Opisthokonta" ]

[ 2363 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 13, 13 ]

4

true

Family

Cytochrome P450, E-class, group I, CYP2A-like

Cyt_P450_E_grp-I_CYP2A-like

7

IPR008068

8,068

Cytochrome P450, E-class, group I, CYP2B-like

Cyt_P450_E_grp-I_CYP2B-like

Family

694

false

Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty ac...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01685" ]

[ "EP450ICYP2B" ]

[ 694 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.14.1", "PWY-5451", "PWY-5665", "PWY-6398", "PWY-6992", "PWY-7466", "R-HSA-211935", "R-HSA-211945", "R-HSA-211981", "R-HSA-211999", "R-MMU-211981" ]

[ "EC:1.14.14.1", "METACYC:PWY-5451", "METACYC:PWY-5665", "METACYC:PWY-6398", "METACYC:PWY-6992", "METACYC:PWY-7466", "REACTOME:R-HSA-211935", "REACTOME:R-HSA-211945", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-211999", "REACTOME:R-MMU-211981" ]

11

[ "1po5", "1suo", "2bdm", "2q6n", "3g5n", "3g93", "3ibd", "3kw4", "3me6", "3mvr", "3qoa", "3qu8", "3r1a", "3r1b", "3tk3", "3tmz", "3ua5", "3uas", "4h1n", "4i91", "4jlt", "4mgj", "4rql", "4rrt", "4zv8", "5e0e", "5e58", "5em4", "5iut", "5iuz", "5uap", "5uda"...

36

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033976" ]

[ "16042601", "17023115", "15128046", "8637843", "16935426" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 2007 ]

5

[ "IPR002401" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 694 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 9, 24 ]

3

true

Family

Cytochrome P450, E-class, group I, CYP2B-like

Cyt_P450_E_grp-I_CYP2B-like

8

IPR008069

8,069

Cytochrome P450, E-class, group I, CYP2D-like

Cyt_P450_E_grp-I_CYP2D-like

Family

5,238

false

This entry represents the CYP2D family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfami...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01686" ]

[ "EP450ICYP2D" ]

[ 5238 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.14", "R-BTA-211935", "R-BTA-211958", "R-BTA-211981", "R-BTA-211999", "R-BTA-9027307", "R-BTA-9749641", "R-HSA-211935", "R-HSA-211958", "R-HSA-211981", "R-HSA-211999", "R-HSA-2142816", "R-HSA-5579011", "R-HSA-9027307", "R-HSA-9749641", "R-MMU-211958", "R-MMU-2142816", "R-RNO-2...

[ "EC:1.14.14", "REACTOME:R-BTA-211935", "REACTOME:R-BTA-211958", "REACTOME:R-BTA-211981", "REACTOME:R-BTA-211999", "REACTOME:R-BTA-9027307", "REACTOME:R-BTA-9749641", "REACTOME:R-HSA-211935", "REACTOME:R-HSA-211958", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-211999", "REACTOME:R-HSA-2142816", ...

23

[ "2f9q", "3qm4", "3tbg", "3tda", "4wnt", "4wnu", "4wnv", "4wnw", "4xry", "4xrz", "5tft", "5tfu", "6csb", "6csd" ]

14

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033977", "PUB00033978" ]

[ "16042601", "17023115", "15128046", "8637843", "16033950", "15817819" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 2005, 2005 ]

6

[ "IPR002401" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5238 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 31, 40, 18, 21 ]

4

true

Family

Cytochrome P450, E-class, group I, CYP2D-like

Cyt_P450_E_grp-I_CYP2D-like

4

IPR008070

8,070

Cytochrome P450, E-class, group I, CYP2E-like

Cyt_P450_E_grp-I_CYP2E-like

Family

309

false

Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty ac...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01687" ]

[ "EP450ICYP2E" ]

[ 309 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REAC...

[ "1.14.14.1", "PWY-5451", "PWY-5665", "PWY-6398", "PWY-6992", "PWY-7466", "R-CFA-211981", "R-CFA-211999", "R-CFA-9027307", "R-CFA-9749641", "R-CFA-9753281", "R-HSA-211981", "R-HSA-211999", "R-HSA-9027307", "R-HSA-9749641", "R-HSA-9753281", "R-MMU-211981", "R-MMU-211999", "R-MMU-90...

[ "EC:1.14.14.1", "METACYC:PWY-5451", "METACYC:PWY-5665", "METACYC:PWY-6398", "METACYC:PWY-6992", "METACYC:PWY-7466", "REACTOME:R-CFA-211981", "REACTOME:R-CFA-211999", "REACTOME:R-CFA-9027307", "REACTOME:R-CFA-9749641", "REACTOME:R-CFA-9753281", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-211999"...

26

[]

0

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033979" ]

[ "16042601", "17023115", "15128046", "8637843", "9784018" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 1998 ]

5

[ "IPR002401" ]

[]

1

0

1

[ "Bilateria" ]

[ 309 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 4, 9 ]

3

true

Family

Cytochrome P450, E-class, group I, CYP2E-like

Cyt_P450_E_grp-I_CYP2E-like

3

IPR008071

8,071

Cytochrome P450, E-class, group I, CYP2J-like

Cyt_P450_E_grp-I_CYP2J-like

Family

1,586

false

This entry represents the CYP2J family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfami...

[ "GO:0004497", "GO:0005506", "GO:0016712", "GO:0020037" ]

[ "monooxygenase activity", "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "heme binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PRINTS" ]

[ "PR01688" ]

[ "EP450ICYP2J" ]

[ 1586 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.14.1", "PWY-5451", "PWY-5665", "PWY-6398", "PWY-6992", "PWY-7466", "R-HSA-211935", "R-HSA-211981", "R-HSA-2142670", "R-MMU-211935", "R-MMU-211981", "R-MMU-2142670", "R-RNO-211935", "R-RNO-211981", "R-RNO-2142670" ]

[ "EC:1.14.14.1", "METACYC:PWY-5451", "METACYC:PWY-5665", "METACYC:PWY-6398", "METACYC:PWY-6992", "METACYC:PWY-7466", "REACTOME:R-HSA-211935", "REACTOME:R-HSA-211981", "REACTOME:R-HSA-2142670", "REACTOME:R-MMU-211935", "REACTOME:R-MMU-211981", "REACTOME:R-MMU-2142670", "REACTOME:R-RNO-211935",...

15

[]

0

[ "PUB00033965", "PUB00033966", "PUB00033967", "PUB00033969", "PUB00033980", "PUB00033981", "PUB00033982", "PUB00096641" ]

[ "16042601", "17023115", "15128046", "8637843", "16842832", "9606960", "14978252", "19923256" ]

[ "Biodiversity of cytochrome P450 redox systems.", "Cytochrome P450--redox partner fusion enzymes.", "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.", "Structural domains of P450-containi...

[ 2005, 2007, 2004, 1995, 2006, 1998, 2004, 2010 ]

8

[ "IPR002401" ]

[]

1

0

1

[ "Bilateria" ]

[ 1586 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 16, 15 ]

4

true

Family

Cytochrome P450, E-class, group I, CYP2J-like

Cyt_P450_E_grp-I_CYP2J-like

4

IPR008073

8,073

Potassium channel subfamily K member 15

TASK5

Family

399

false

TASK is a member of the TWIK-related (two P-domain) K + channel family identified in human tissues [ ]. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found in the brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 2...

[ "GO:0005267", "GO:0071805", "GO:0016020" ]

[ "potassium channel activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01690" ]

[ "TASK5CHANNEL" ]

[ 399 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5576886", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-5576886", "REACTOME:R-RNO-5576886" ]

2

[]

0

[ "PUB00001308", "PUB00010551" ]

[ "9312005", "11680614" ]

[ "TASK, a human background K+ channel to sense external pH variations near physiological pH.", "TASK-5, a novel member of the tandem pore K+ channel family." ]

[ 1997, 2001 ]

2

[ "IPR003092" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 399 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3 ]

3

true

Family

Potassium channel subfamily K member 15

TASK5

6

IPR008074

8,074

Two pore domain potassium channel, TRAAK

2pore_dom_K_chnl_TRAAK

Family

241

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005267", "GO:0071805", "GO:0016020" ]

[ "potassium channel activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01691" ]

[ "TRAAKCHANNEL" ]

[ 241 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1299503", "R-HSA-5576886", "R-MMU-1299503", "R-MMU-5576886", "R-RNO-1299503", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-1299503", "REACTOME:R-HSA-5576886", "REACTOME:R-MMU-1299503", "REACTOME:R-MMU-5576886", "REACTOME:R-RNO-1299503", "REACTOME:R-RNO-5576886" ]

6

[ "3um7", "4i9w", "4rue", "4ruf", "4wfe", "4wff", "4wfg", "4wfh", "6pis" ]

9

[ "PUB00001055", "PUB00001278", "PUB00001298", "PUB00001308", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00004219", "PUB00004878", "PUB00006577", "PUB00009378", "PUB00010552" ]

[ "1772658", "8605869", "9003761", "9312005", "1879548", "1373731", "2448635", "2451788", "7651518", "8917578", "2555158", "11178249", "9880510" ]

[ "The molecular biology of K+ channels.", "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.", "Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.", "TASK, a human background K+ channel to sense external pH variatio...

[ 1991, 1996, 1996, 1997, 1991, 1992, 1988, 1988, 1995, 1996, 1989, 2000, 1999 ]

13

[ "IPR003280" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 241 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 2 ]

3

true

Family

Two pore domain potassium channel, TRAAK

2pore_dom_K_chnl_TRAAK

9

IPR008075

8,075

Lipocalin-interacting membrane receptor

LIMR

Family

4,189

false

Beyond its interaction with Lipocalin-1 (Lcn-1), the precise physiological function of lipocalin-1 interacting membrane receptor (LIMR) is unknown [ ]. LIMR can mediate the internalization of Lcn-1 in cultured cells, suggesting a role in cell signaling [ ]. It could be involved in the detoxification of the ligands boun...

[]

0

[ "PRINTS", "PANTHER" ]

[ "PR01692", "PTHR12625" ]

[ "LIPOCALINIMR", "" ]

[ 3926, 4008 ]

2

[]

0

[]

0

[ "PUB00006109", "PUB00010385", "PUB00080712", "PUB00080714" ]

[ "1400345", "11287427", "26512105", "12591932" ]

[ "cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily.", "Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display.", "Fly LMBR1/LIMR-type protein Lilipod promotes germ-line stem cell self-renew...

[ 1992, 2001, 2015, 2003 ]

4

[ "IPR006876" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "marine metagenome" ]

[ 8, 70, 4110, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 28, 6, 8 ]

6

true

Family

Lipocalin-interacting membrane receptor

LIMR

7

IPR008077

8,077

GPCR, family 2, brain-specific angiogenesis inhibitor

GPCR_2_brain_angio_inhib

Family

5,902

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0016525", "GO:0016020" ]

[ "negative regulation of angiogenesis", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01694" ]

[ "BAIPRECURSOR" ]

[ 5902 ]

1

[]

0

[ "4dlo", "8oek" ]

2

[ "PUB00001208", "PUB00004310", "PUB00004961", "PUB00005147", "PUB00005148", "PUB00010553", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816", "PUB00086878" ]

[ "1646711", "1314625", "8170923", "1658940", "1658941", "9393972", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293", "27832497" ]

[ "Molecular cloning and expression of a cDNA encoding the secretin receptor.", "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.", "Fingerprinting G-protein-coupled receptors.", "Expression cloning of an adenylate cyclase-coupled calcitonin receptor.", ...

[ 1991, 1992, 1994, 1991, 1991, 1997, 2003, 1994, 2005, 2009, 2006, 2013, 2016 ]

13

[ "IPR000832" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 5902 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 92, 17, 22, 16 ]

4

true

Family

GPCR, family 2, brain-specific angiogenesis inhibitor

GPCR_2_brain_angio_inhib

8

IPR008078

8,078

GPCR family 2, Ig-hepta-like receptor

GPCR_2_Ig-hepta-like_rcpt

Family

2,025

false

Ig-Hepta/GPR116 is a member of the G protein-coupled receptor family. It has been named Ig-hepta due to the presence of two immunoglobulin-like repeats in its large extracellular domain. The receptor is expressed predominantly in the lung, this expression being strongly induce postnatally. Biochemical analysis indicate...

[ "GO:0004930", "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01695" ]

[ "IGHEPTARCPTR" ]

[ 2025 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5683826", "R-MMU-5683826", "R-RNO-5683826" ]

[ "REACTOME:R-HSA-5683826", "REACTOME:R-MMU-5683826", "REACTOME:R-RNO-5683826" ]

3

[ "7wu3", "7wu4", "7wu5", "7wxu", "7wxw", "7wy0", "7wz7", "7x2v", "8g2y" ]

9

[ "PUB00001208", "PUB00004310", "PUB00005147", "PUB00005148", "PUB00010554", "PUB00075336", "PUB00075337" ]

[ "1646711", "1314625", "1658940", "1658941", "10391944", "25778400", "22837050" ]

[ "Molecular cloning and expression of a cDNA encoding the secretin receptor.", "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.", "Expression cloning of an adenylate cyclase-coupled calcitonin receptor.", "A G protein-linked receptor for parathyroid horm...

[ 1991, 1992, 1991, 1991, 1999, 2015, 2012 ]

7

[ "IPR000832" ]

[]

1

0

1

[ "Vertebrata" ]

[ 2025 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 12, 11, 10 ]

4

true

Family

GPCR family 2, Ig-hepta-like receptor

GPCR_2_Ig-hepta-like_rcpt

7

IPR008079

8,079

Voltage-dependent calcium channel, L-type, beta-3 subunit

VDCC_L_b3su

Family

1,392

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01696" ]

[ "LCACHANNELB3" ]

[ 1392 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-HSA-400042", "R-HSA-419037", "R-HSA-422356", "R-HSA-9856532", "R-MMU-112308", "R-MMU-422356", "R-RNO-112308", "R-RNO-422356" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-HSA-400042", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-422356", "REACTOME:R-HSA-9856532", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-422356", "REACTOME:R-RNO-112308", "REACTOME:R-RNO-422356" ]

9

[ "2d46", "7mix", "7miy", "7uhf", "7uhg", "8e59", "8e5a", "8e5b", "8epl", "8fd7", "8fhs", "8we6", "8we7", "8we8", "8we9", "8x90", "8x91", "8x93" ]

18

[ "PUB00007090", "PUB00010555", "PUB00036034" ]

[ "9153247", "7679112", "14657414" ]

[ "Beta subunit heterogeneity in neuronal L-type Ca2+ channels.", "Cloning and expression of a third calcium channel beta subunit.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels." ]

[ 1997, 1993, 2003 ]

3

[ "IPR000584" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1392 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 18, 4, 6 ]

4

true

Family

Voltage-dependent calcium channel, L-type, beta-3 subunit

VDCC_L_b3su

8

IPR008081

8,081

Cytoplasmic FMR1-interacting

Cytoplasmic_FMR1-int

Family

5,720

false

This entry includes cytoplasmic fragile X messenger ribonucleoprotein 1-interacting proteins from humans and their homologues, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. In humans, there are two members, CYFIP1 and CYFIP2. They both interact with FMRP (Fragile X ...

[ "GO:0031267", "GO:0030833" ]

[ "small GTPase binding", "regulation of actin filament polymerization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PRINTS", "PANTHER" ]

[ "PF05994", "PIRSF008153", "PR01698", "PTHR12195" ]

[ "FragX_IP", "FMR1_interacting", "CYTOFMRPINTP", "" ]

[ 5362, 4969, 4600, 5661 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-2029482", "R-CEL-5663213", "R-CEL-6798695", "R-CEL-9013149", "R-CEL-9013404", "R-CEL-9013408", "R-CEL-9013423", "R-DDI-2029482", "R-DDI-5663213", "R-DDI-6798695", "R-DDI-9013149", "R-DDI-9013404", "R-DDI-9013408", "R-DDI-9013423", "R-DME-2029482", "R-DME-4420097", "R-DME-56632...

[ "REACTOME:R-CEL-2029482", "REACTOME:R-CEL-5663213", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013404", "REACTOME:R-CEL-9013408", "REACTOME:R-CEL-9013423", "REACTOME:R-DDI-2029482", "REACTOME:R-DDI-5663213", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9013149", "REACTOM...

41

[ "3p8c", "4n78", "7usc", "7usd", "7use" ]

5

[ "PUB00011944", "PUB00085142", "PUB00085143", "PUB00085144", "PUB00085145", "PUB00085146" ]

[ "11438699", "26824476", "15269173", "15294869", "27524794", "18805096" ]

[ "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.", "Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks.", "Sra-1 inter...

[ 2001, 2016, 2004, 2004, 2016, 2008 ]

6

[]

0

null

[ "Eukaryota" ]

[ 5720 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 8, 3, 34, 10, 4, 8, 14 ]

9

true

Family

Cytoplasmic FMR1-interacting

Cytoplasmic_FMR1-int

9

IPR008083

8,083

CD34 antigen

CD34

Family

1,168

false

The CD34 group of monoclonal antibodies recognises CD34 (also termed CD34 antigen), a 105-120kDa cell surface glycoprotein, which is selectively expressed by human myeloid and lymphoid progenitor cells, including the haemopoietic stem cell. The protein is also expressed on vascular endothelial cells. Here, it is concen...

[ "GO:0007155", "GO:0016020" ]

[ "cell adhesion", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01700", "PTHR16677" ]

[ "CD34ANTIGEN", "" ]

[ 639, 1168 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-198933", "R-HSA-198933", "R-MMU-198933" ]

[ "REACTOME:R-CFA-198933", "REACTOME:R-HSA-198933", "REACTOME:R-MMU-198933" ]

3

[]

0

[ "PUB00010258", "PUB00010259" ]

[ "1694174", "1709048" ]

[ "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells.", "The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts." ]

[ 1990, 1991 ]

2

[ "IPR013836" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1168 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 9, 6, 2 ]

4

true

Family

CD34 antigen

CD34

6

IPR008087

8,087

Autoimmune regulator, AIRE

AIRE

Family

914

false

AIRE (AutoImmune REgulator) is a transcription factor that plays an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (T...

[ "GO:0003677", "GO:0045182", "GO:0006959", "GO:0005634", "GO:0005737" ]

[ "DNA binding", "translation regulator activity", "humoral immune response", "nucleus", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01711" ]

[ "AIREGULATOR" ]

[ 914 ]

1

[]

0

[]

0

[ "PUB00010323", "PUB00010341", "PUB00010343", "PUB00010394", "PUB00097088", "PUB00097089" ]

[ "9398840", "10049735", "10208866", "11533054", "26972725", "26084028" ]

[ "An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.", "Isolation and characterization of the mouse Aire gene.", "Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.", "The autoimmune regulator (AIRE) is a DNA...

[ 1997, 1999, 1999, 2001, 2016, 2015 ]

6

[ "IPR043563" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 914 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 7, 6 ]

4

true

Family

Autoimmune regulator, AIRE

AIRE

6

IPR008088

8,088

Alpha giardin

Alpha_giardin

Family

117

false

Giardia lamblia (Giardia intestinalis) is a protozoan parasite of numerous mammals, including Homo sapiens [ ]. It belongs to the phylum Sarcomastigophora, and is amongst the most primitive eukaryotes identified to date. It is the main causative agent of global protozoan diarrhoea, and severe infection can cause giardi...

[ "GO:0005509", "GO:0005544", "GO:0007010" ]

[ "calcium ion binding", "calcium-dependent phospholipid binding", "cytoskeleton organization" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PRINTS" ]

[ "PR01712" ]

[ "ALPHAGIARDIN" ]

[ 117 ]

1

[]

0

[ "2ii2", "2iic", "4evf", "4evh" ]

4

[ "PUB00001395", "PUB00010286", "PUB00010295", "PUB00010344", "PUB00010390", "PUB00015121", "PUB00093769" ]

[ "1646719", "7630843", "8278341", "10220891", "11432808", "15059252", "22796298" ]

[ "Amino acid sequence analysis of the annexin super-gene family of proteins.", "Giardiasis. Taming this pervasive parasitic infection.", "Characterization of an immunodominant Giardia lamblia protein antigen related to alpha giardin.", "Functional identification of alpha 1-giardin as an annexin of Giardia lamb...

[ 1991, 1995, 1993, 1999, 2001, 2004, 2012 ]

7

[]

0

null

[ "Hexamitidae" ]

[ 117 ]

1

[]

0

true

Family

Alpha giardin

Alpha_giardin

1

IPR008090

8,090

Ferric iron reductase

Fe_iron_reduct

Family

2,644

false

Iron is essential for growth in both bacteria and mammals. Controlling the amount of free iron in solution is often used as a tactic by hosts to limit invasion of pathogenic microbes; binding iron tightly within protein molecules can accomplish this. Such iron-protein complexes include haem in blood, lactoferrin in tea...

[]

0

[ "PRINTS", "NCBIFAM" ]

[ "PR01714", "TIGR03951" ]

[ "2FE2SRDCTASE", "Fe_III_red_FhuF" ]

[ 1915, 2574 ]

2

[]

0

[ "7qp5" ]

1

[ "PUB00006650", "PUB00010339", "PUB00010345", "PUB00101361" ]

[ "8057905", "9990318", "10322040", "33559753" ]

[ "Detection, isolation, and characterization of siderophores.", "FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center.", "SufS is a NifS-like protein, and SufD is necessary for stability of the [2Fe-2S] FhuF protein in Escherichia coli.", "Conjuring up a ghost: structural and ...

[ 1994, 1998, 1999, 2021 ]

4

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 2634, 10 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ferric iron reductase

Fe_iron_reduct

5

IPR008092

8,092

Small ribosomal subunit protein mS29, metazoa

Ribosomal_mS29_met

Family

2,100

false

This entry represents the family of small ribosomal subunit mitochondrial protein mS29 which was originally described as death-associated-protein-3 (DAP-3). This protein was also known as MRPS29 in mammals and RSM23 in yeast. These proteins carry a P-loop DNA-binding motif, and induce apoptosis [ ]. mS29 has been shown...

[ "GO:0006915", "GO:0005761", "GO:0015935" ]

[ "apoptotic process", "mitochondrial ribosome", "small ribosomal subunit" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01716" ]

[ "DEATHASSOCP3" ]

[ 2100 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.5.-", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "EC:3.6.5.-", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

8

[ "3j9m", "3jd5", "5aj3", "5aj4", "6gaw", "6gaz", "6neq", "6nf8", "6nu2", "6nu3", "6rw4", "6rw5", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5i", "7a5k", "7l08", "7nqh", "7nql"...

77

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00010337", "PUB00010371" ]

[ "11297922", "11290319", "11114498", "9889192", "11017876" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.", "The apoptosis mediator mDAP-3...

[ 2001, 2001, 2000, 1999, 2000 ]

5

[ "IPR019368" ]

[]

1

0

1

[ "Eukaryota", "Zoogloea oleivorans" ]

[ 2099, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 8, 9, 6 ]

6

true

Family

Small ribosomal subunit protein mS29, metazoa

Ribosomal_mS29_met

7

IPR008093

8,093

T cell antigen CD28

CD28

Family

600

false

Antigen (Ag) recognition by the T cell receptor (TCR) induces activation of T lymphocytes. However, TCR-mediated signals alone are insufficient for efficient T cell activation, and additional co-stimulatory signals are required. One of the most important surface molecules that delivers co-stimulatory signals for T cell...

[ "GO:0006955", "GO:0016020" ]

[ "immune response", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01717" ]

[ "CD28ANTIGEN" ]

[ 600 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1257604", "R-HSA-164939", "R-HSA-2219530", "R-HSA-389356", "R-HSA-389357", "R-HSA-389359", "R-HSA-6811558", "R-MMU-1257604", "R-MMU-389356", "R-MMU-389357", "R-MMU-389359", "R-MMU-6811558", "R-RNO-1257604", "R-RNO-389356", "R-RNO-389357", "R-RNO-389359", "R-RNO-6811558" ]

[ "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-164939", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-389356", "REACTOME:R-HSA-389357", "REACTOME:R-HSA-389359", "REACTOME:R-HSA-6811558", "REACTOME:R-MMU-1257604", "REACTOME:R-MMU-389356", "REACTOME:R-MMU-389357", "REACTOME:R-MMU-389359", "REACTOME:R-MMU...

17

[ "2nae" ]

1

[ "PUB00010266", "PUB00010267", "PUB00010399", "PUB00010400", "PUB00010414", "PUB00010419" ]

[ "2157764", "2162892", "11698427", "11698433", "11827987", "11884439" ]

[ "The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.", "The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.", "Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.", ...

[ 1990, 1990, 2001, 2001, 2002, 2002 ]

6

[ "IPR040216" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 600 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 2 ]

3

true

Family

T cell antigen CD28

CD28

3

IPR008094

8,094

Claudin-15

Claudin15

Family

204

false

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ...

[ "GO:0005198", "GO:0005923" ]

[ "structural molecule activity", "bicellular tight junction" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01718" ]

[ "CLAUDIN15" ]

[ 204 ]

1

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[ "4p79" ]

1

[ "PUB00070979", "PUB00070980", "PUB00070981", "PUB00070982" ]

[ "24665401", "20188437", "21372174", "10562289" ]

[ "Claudin interactions in and out of the tight junction.", "The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.", "Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occlud...

[ 2013, 2010, 2011, 1999 ]

4

[ "IPR006187" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 204 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1 ]

3

true

Family

Claudin-15

Claudin15

2

IPR008095

8,095

MHC class II transactivator

MHC_II_transact

Family

1,241

false

Class II transactivator (CIITA) determines the level, cell type specificity, inducibility and extinction of MHC-II expression. CIITA is also the obligatory mediator of INF-gamma inducible MHC-II expression. Thus control of MHC-II expression is ultimately dependent on the control of expression of the CIITA gene itself. ...

[ "GO:0005524", "GO:0006355" ]

[ "ATP binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS" ]

[ "PR01719" ]

[ "MHCIIACTVATR" ]

[ 1241 ]

1

[ "REACTOME" ]

[ "R-HSA-877300" ]

[ "REACTOME:R-HSA-877300" ]

1

[]

0

[ "PUB00010315", "PUB00010329", "PUB00010367", "PUB00010389", "PUB00010392", "PUB00010406", "PUB00010407", "PUB00010413" ]

[ "9184229", "9600954", "10809673", "11413136", "11438649", "11777970", "11792431", "11823510" ]

[ "Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.", "CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.", "CI...

[ 1997, 1998, 2000, 2001, 2001, 2002, 2002, 2002 ]

8

[]

0

null

[ "Opisthokonta" ]

[ 1241 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 9, 11, 10 ]

4

true

Family

MHC class II transactivator

MHC_II_transact

3

IPR008096

8,096

Cytotoxic T-lymphocyte antigen 4

CTLA4

Family

726

false

T cell-dependent immune processes require cell-surface interactions that mediate the initiation, modulation and the ultimate course of the response. The specificity of T cell recognition is determined by the engagement of the T cell receptor (TCR) on T cells with cognate peptide-MHC complexes presented by antigen prese...

[ "GO:0006955", "GO:0016020" ]

[ "immune response", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01720" ]

[ "CTLANTIGEN4" ]

[ 726 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-389356", "R-HSA-389513", "R-HSA-8877330", "R-MMU-389356", "R-MMU-389513" ]

[ "REACTOME:R-HSA-389356", "REACTOME:R-HSA-389513", "REACTOME:R-HSA-8877330", "REACTOME:R-MMU-389356", "REACTOME:R-MMU-389513" ]

5

[ "1ah1", "1dqt", "1i85", "1i8l", "2x44", "3bx7", "3osk", "4kkn", "4n8p", "5e56", "5e5m", "5ggv", "5tru", "5xj3", "6rp8", "6rpj", "6rqm", "6xy2", "7dv4", "7elx", "7su0", "7su1", "8gab", "8hit", "9dq3", "9dq4", "9dq5" ]

27

[ "PUB00010260", "PUB00010330", "PUB00010376", "PUB00010408", "PUB00010415" ]

[ "1714933", "9600957", "11052947", "11807776", "11841692" ]

[ "CTLA-4 is a second receptor for the B cell activation antigen B7.", "B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.", "Structure of murine CTLA-4 and its role in modulating T cell responsiveness.", "CTLA-4 regulates cell cycle progression...

[ 1991, 1998, 2000, 2002, 2002 ]

5

[ "IPR040216" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 726 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 6 ]

3

true

Family

Cytotoxic T-lymphocyte antigen 4

CTLA4

6

IPR008098

8,098

Gamma-aminobutyric-acid A receptor delta subunit

GABAAd_rcpt

Family

922

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01722" ]

[ "GABAARDELTA" ]

[ 922 ]

1

[]

0

[ "7qn5", "7qn6", "7qn7", "7qn8", "7qn9", "7qnc", "7qnd" ]

7

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR006028" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 922 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 3, 3 ]

4

true

Family

Gamma-aminobutyric-acid A receptor delta subunit

GABAAd_rcpt

9

IPR008099

8,099

Gamma-aminobutyric-acid A receptor epsilon subunit

GABAAe_rcpt

Family

40

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01723" ]

[ "GABAAREPSLON" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010312", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "9039914", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1997, 1999, 2008, 2004, 2008, 2004 ]

14

[ "IPR006028" ]

[]

1

0

1

[ "Euarchontoglires" ]

[ 40 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 8 ]

3

true

Family

Gamma-aminobutyric-acid A receptor epsilon subunit

GABAAe_rcpt

3

IPR008100

8,100

Gamma-aminobutyric-acid A receptor pi subunit

GABAAp_rcpt

Family

727

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01724" ]

[ "GABAARPI" ]

[ 727 ]

1

[]

0

[ "8vsz", "8vv0" ]

2

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010314", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "9182563", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1997, 1999, 2008, 2004, 2008, 2004 ]

14

[ "IPR006028" ]

[]

1

0

1

[ "Vertebrata" ]

[ 727 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 9, 2, 3 ]

4

true

Family

Gamma-aminobutyric-acid A receptor pi subunit

GABAAp_rcpt

8

IPR008101

8,101

Gamma-aminobutyric-acid A receptor theta subunit

GABAAt_rcpt

Family

167

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006811", "GO:0016020" ]

[ "GABA-A receptor activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01725" ]

[ "GABAARTHETA" ]

[ 167 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1236394", "R-HSA-977443", "R-MMU-977443" ]

[ "REACTOME:R-HSA-1236394", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443" ]

3

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR006028" ]

[]

1

0

1

[ "Eutheria" ]

[ 167 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 6 ]

3

true

Family

Gamma-aminobutyric-acid A receptor theta subunit

GABAAt_rcpt

9

IPR008102

8,102

Histamine H4 receptor

Histamine_H4_rcpt

Family

171

false

Histamine plays an important role in a variety of pathophysiological conditions. In allergic conditions, histamine is released from basophils and mast cells and is responsible for symptoms of allergic conditions of the skin and airways. In the gastric mucosa, gastric induced histamine release stimulates parietal cells ...

[ "GO:0004969", "GO:0006954", "GO:0007186", "GO:0007204", "GO:0043408", "GO:0016020" ]

[ "histamine receptor activity", "inflammatory response", "G protein-coupled receptor signaling pathway", "positive regulation of cytosolic calcium ion concentration", "regulation of MAPK cascade", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "biological_process", "cellular_component" ]

6

[ "PRINTS" ]

[ "PR01726" ]

[ "HISTAMINEH4R" ]

[ 171 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "265", "R-HSA-390650", "R-HSA-418594", "R-MMU-390650", "R-MMU-418594", "R-RNO-390650", "R-RNO-418594" ]

[ "IUPHAR:265", "REACTOME:R-HSA-390650", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-390650", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-390650", "REACTOME:R-RNO-418594" ]

7

[ "7yfc", "7yfd", "8hn8", "8hoc", "8jxt", "8jxv", "8jxw", "8jxx", "8yn9", "8yna", "9jed", "9l42" ]

12

[ "PUB00010558", "PUB00063500", "PUB00063501", "PUB00063502", "PUB00063503", "PUB00063504", "PUB00063506", "PUB00063507", "PUB00063556", "PUB00063557", "PUB00063558" ]

[ "11179434", "16402096", "19772756", "12113221", "17490952", "19843401", "9311023", "12626656", "15274415", "19309354", "22202056" ]

[ "Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.", "Histamine and its receptors.", "Intranasal antihistamines for allergic rhinitis: mechanism of action.", "Histamine and antihistamines in anaphylaxis.", "Histamine and histamine intolerance.", "...

[ 2001, 2006, 2009, 2002, 2007, 2009, 1997, 2003, 2004, 2009, 2012 ]

11

[ "IPR000276" ]

[]

1

0

1

[ "Mammalia" ]

[ 171 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3 ]

3

true

Family

Histamine H4 receptor

Histamine_H4_rcpt

9

IPR008103

8,103

KiSS-1 peptide receptor

KiSS_1_rcpt

Family

1,169

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0004930", "GO:0016020" ]

[ "G protein-coupled receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01728" ]

[ "KISS1RECEPTR" ]

[ 1169 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "266", "R-HSA-375276", "R-HSA-416476", "R-MMU-375276", "R-MMU-416476", "R-RNO-375276", "R-RNO-416476" ]

[ "IUPHAR:266", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476" ]

7

[ "8xgo", "8xgs", "8xgu", "8zjd", "8zje" ]

5

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00010559", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "11385580", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.",...

[ 1990, 1988, 1993, 1994, 2001, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[ "IPR000276" ]

[]

1

0

1

[ "Bilateria" ]

[ 1169 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 4, 3 ]

4

true

Family

KiSS-1 peptide receptor

KiSS_1_rcpt

5

IPR008104

8,104

Macrophage infectivity potentiator

INFPOTNTIATR

Family

1,197

false

Legionella pneumophila, the causative agent of Legionnaire's disease, is a facultative intracellular microbe that commonly infects human lung monocytes and macrophages and causes pneumonia [ ]. It is water-borne and highly virulent, relying on several specific pathogenic factors to invade and infect the alveolar tissue...

[ "GO:0003755", "GO:0016020" ]

[ "peptidyl-prolyl cis-trans isomerase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01730" ]

[ "INFPOTNTIATR" ]

[ 1197 ]

1

[ "EC" ]

[ "5.2.1.8" ]

[ "EC:5.2.1.8" ]

1

[ "1fd9", "8bjc", "8bjd", "8r39", "8ruo" ]

5

[ "PUB00010255", "PUB00010272", "PUB00010282", "PUB00010296", "PUB00010393" ]

[ "1379319", "2925252", "7516906", "8347938", "11524681" ]

[ "Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity.", "DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity.", "Characterization of Mip proteins of Legionella pneumophila.", "Analysis of virulence factors of Legionella pne...

[ 1992, 1989, 1994, 1993, 2001 ]

5

[]

0

null

[ "Bacteria", "Mollusca", "metagenomes" ]

[ 1176, 2, 19 ]

3

[]

0

true

Family

Macrophage infectivity potentiator

INFPOTNTIATR

7

IPR008106

8,106

Neisseria toxin MafB

Adhesin_MafB

Family

250

false

MafB constitutes a family of secreted toxins in pathogenic Neisseria species, probably involved in interbacterial competition [ ]. Genes immediately downstream of mafB encode a specific immunity protein (MafI). MafB proteins exhibit a signal peptide sequence, a N-terminal conserved domain and a C-terminal variable regi...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF06255", "PR01732" ]

[ "MafB", "ADHESINMAFB" ]

[ 250, 195 ]

2

[]

0

[]

0

[ "PUB00010382", "PUB00073618" ]

[ "11173033", "25569427" ]

[ "Meningococcal pathogenesis: at the boundary between the pre- and post-genomic eras.", "A new family of secreted toxins in pathogenic Neisseria species." ]

[ 2001, 2015 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 250 ]

1

[]

0

true

Family

Neisseria toxin MafB

Adhesin_MafB

2

IPR008107

8,107

Mycoplasma P48 major surface lipoprotein

Mycoplasma_p48

Family

483

false

Mycoplasma species are unique amongst bacteria in having very small genomes and lacking cell walls, and are wholly dependent on their host for survival, be it in a symbiotic or pathogenic lifestyle [ ]. Some virulent species can quickly adapt to new environments, and utilise a number of cell surface moieties to attach ...

[]

0

[ "PIRSF", "PRINTS" ]

[ "PIRSF032900", "PR01733" ]

[ "Mycoplasma_p48", "LIPPROTEIN48" ]

[ 89, 482 ]

2

[]

0

[]

0

[ "PUB00010310", "PUB00010319", "PUB00010350", "PUB00010360" ]

[ "8921000", "9286066", "10455005", "10703704" ]

[ "cDNA and genomic cloning and expression of the P48 monocytic differentiation/activation factor, a Mycoplasma fermentans gene product.", "New developments in diagnostic and treatment of mycoplasma infections in humans.", "Expression of the monocytic differentiation/activation factor P48 in Mycoplasma species.",...

[ 1996, 1997, 1999, 2000 ]

4

[]

0

null

[ "Bacteria", "Hirondellea gigas", "metagenomes" ]

[ 472, 1, 10 ]

3

[]

0

true

Family

Mycoplasma P48 major surface lipoprotein

Mycoplasma_p48

5

IPR008108

8,108

Phosphatase IpgD/SopB

IpgD/SopB

Family

889

false

Some Gram-negative animal enteropathogens express a specialised secretion system to directly "inject" exotoxins into the cytoplasm of host cells. Dubbed the type III secretion system, it is of specific interest to researchers, as the components of such a system are only expressed in pathogenic strains [ ]. The system i...

[ "GO:0016791" ]

[ "phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PFAM", "PRINTS" ]

[ "NF011905", "PF05925", "PR01734" ]

[ "PRK15378.1", "IpgD", "TYPE3OMBPROT" ]

[ 727, 889, 789 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531", "PWY-7771...

[ "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720", "METACYC:PWY-6...

36

[ "4did", "8jzl" ]

2

[ "PUB00007817", "PUB00011913", "PUB00057230" ]

[ "11018143", "12356723", "9826652" ]

[ "Assembly and function of type III secretory systems.", "Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.", "SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase." ]

[ 2000, 2002, 1998 ]

3

[]

0

null

[ "Bacteria", "Eutetramitia", "invertebrate metagenome" ]

[ 882, 6, 1 ]

3

[]

0

true

Family

Phosphatase IpgD/SopB

IpgD/SopB

4

IPR008109

8,109

P2Y13 purinoceptor

P2Y13_rcpt

Family

979

false

There are three distinct families of extracellular receptors for purine and pyrimidine nucleotides [ ], known as P1, P2X and P2Y purinoceptors [ ]. These receptors induce a wide variety of biological effects and are involved in many different cellular functions [ , , ]. P2X receptors are ligand-gated ion channels, wher...

[ "GO:0045028", "GO:0007186", "GO:0007194", "GO:0016020" ]

[ "G protein-coupled purinergic nucleotide receptor activity", "G protein-coupled receptor signaling pathway", "negative regulation of adenylate cyclase activity", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01735" ]

[ "P2Y13PRNCPTR" ]

[ 979 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-417957", "R-HSA-418594", "R-MMU-417957", "R-MMU-418594", "R-RNO-417957", "R-RNO-418594" ]

[ "REACTOME:R-HSA-417957", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-417957", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-417957", "REACTOME:R-RNO-418594" ]

6

[ "4ntj", "4pxz", "4py0", "7pp1" ]

4

[ "PUB00007054", "PUB00010560", "PUB00018923", "PUB00028347", "PUB00033968", "PUB00066193", "PUB00066194", "PUB00066195", "PUB00066196", "PUB00066197", "PUB00066198", "PUB00066203", "PUB00066204", "PUB00066205", "PUB00066206", "PUB00066207", "PUB00066208", "PUB00066209", "PUB000662...

[ "12270951", "11961076", "11546776", "8872457", "11111826", "10629443", "20471713", "11099464", "19921464", "11734617", "16257449", "9364468", "7724657", "16968944", "8508924", "19386608", "8921391", "8702478", "12724320", "18404483", "9755289", "11794691", "16914897", "...

[ "Molecular physiology of P2X receptors.", "P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.", "Identification of a novel human ADP receptor coupled to G(i).", "Modelling the P2Y purinoceptor using rhodopsin as template.", "Molecular pharmacology of P...

[ 2002, 2002, 2001, 1995, 2000, 2000, 2011, 2000, 2010, 2001, 2006, 1997, 1994, 2006, 1993, 2009, 1996, 1996, 2003, 2006, 1998, 2001, 2006, 2006, 2000, 2004, 2003, 2004 ]

28

[ "IPR000276" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 979 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 6 ]

3

true

Family

P2Y13 purinoceptor

P2Y13_rcpt

6

IPR008110

8,110

Porphyromonas gingivalis fimbrillin protein

Fimbrillin

Family

100

false

Periodontal disease in humans is a major health problem in the developed world, and is caused by a number of specialised pathogens that inhabit the oral cavity. Amongst the bacterial species culturable from periodontal lesions are the streptococcal microbes Streptococcus mutans and Streptococcus sobrinus, and the Gram-...

[ "GO:0005198", "GO:0007155", "GO:0009289" ]

[ "structural molecule activity", "cell adhesion", "pilus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01737" ]

[ "FIMBRILLIN" ]

[ 100 ]

1

[]

0

[ "4q98", "6jzj", "6jzk", "6kmf" ]

4

[ "PUB00010262", "PUB00010271", "PUB00010404" ]

[ "1987052", "2895100", "11748193" ]

[ "Porphyromonas (Bacteroides) gingivalis fimbrillin: size, amino-terminal sequence, and antigenic heterogeneity.", "Molecular cloning and sequencing of the gene encoding the fimbrial subunit protein of Bacteroides gingivalis.", "Functional differences among FimA variants of Porphyromonas gingivalis and their eff...

[ 1991, 1988, 2002 ]

3

[]

0

null

[ "Bacteroidales" ]

[ 100 ]

1

[]

0

true

Family

Porphyromonas gingivalis fimbrillin protein

Fimbrillin

1