LiteFold/InterPro · Datasets at Hugging Face

IPR009347

9,347

Rice tungro bacilliform virus P46

RTBV_P46

Family

41

false

This family consists of several Rice tungro bacilliform virus P46 proteins (also known as P4). The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06216" ]

[ "RTBV_P46" ]

[ 41 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhynchospora tenuis", "Tungrovirus" ]

[ 9, 32 ]

2

[]

0

true

Family

Rice tungro bacilliform virus P46

RTBV_P46

9

IPR009348

9,348

Nitrogen permease regulator 2-like

NPR2-like

Family

3,919

false

This family of regulators are involved in post-translational control of nitrogen permease. In mammals, members may act as a tumour suppressor that suppresses cell growth and enhances sensitivity to various anticancer drugs [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06218", "PTHR12991" ]

[ "NPR2", "" ]

[ 3856, 3865 ]

2

[ "GP", "REACTOME", "REACTOME" ]

[ "GenProp2028", "R-HSA-9639288", "R-MMU-9639288" ]

[ "GP:GenProp2028", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288" ]

3

[ "6ces", "6cet", "7t3a", "7t3b", "7t3c", "8adl", "8ae6", "8fw5", "9h4q", "9h5k", "9v0j" ]

11

[ "PUB00053872", "PUB00063283", "PUB00085662" ]

[ "19521502", "18616680", "23723238" ]

[ "A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.", "TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.", "A Tumor suppressor complex with GAP activity for the Rag GTPases that s...

[ 2009, 2008, 2013 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3919 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 1, 1, 4, 2, 1, 4, 1, 1 ]

9

true

Family

Nitrogen permease regulator 2-like

NPR2-like

9

IPR009349

9,349

TRIP4/RQT4, C2HC5-type zinc finger

TRIP4/RQT4_C2HC5_Znf

Domain

4,226

false

This entry represents a C2HC5-type zinc finger found in human activating signal cointegrator 1 (ASC-1, also known as TRIP4) and its orthologue from yeast RQC trigger complex subunit RQT4 which function as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that deg...

[ "GO:0008270", "GO:0072344", "GO:0005634", "GO:0180022" ]

[ "zinc ion binding", "rescue of stalled cytosolic ribosome", "nucleus", "RQC-trigger complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06221" ]

[ "zf-C2HC5" ]

[ 4226 ]

1

[]

0

[ "7zpq", "7zrs", "7zuw", "8alz" ]

4

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00071531", "PUB00088961", "PUB00151150", "PUB00151151", "PUB00151152" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "10454579", "25219498", "32099016", "32579943", "36302773" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 1999, 2014, 2020, 2020, 2022 ]

11

[]

0

null

[ "Eukaryota", "Methanococcales", "Sporomusa" ]

[ 4221, 3, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 2, 2, 3, 1, 1, 11, 1, 1, 3 ]

12

true

Domain

TRIP4/RQT4, C2HC5-type zinc finger

TRIP4/RQT4_C2HC5_Znf

1

IPR009350

9,350

Minor tail T

Phage_tail_T

Domain

1,979

false

This entry represents the 'T' domain of the tail assembly protein GT from lambda-like viruses and their prophage. In bacteriophage lambda, the overlapping open reading frames G and T are expressed by a programmed translational frameshift to produce the tail assembly proteins G and GT [ ]. Tail assembly protein GT share...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06223", "TIGR01715" ]

[ "Phage_tail_T", "phage_lam_T" ]

[ 1972, 895 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00012906", "PUB00094496", "PUB00094497" ]

[ "8230192", "23911548", "23851014" ]

[ "A programmed translational frameshift is required for the synthesis of a bacteriophage lambda tail assembly protein.", "Chaperone-protein interactions that mediate assembly of the bacteriophage lambda tail to the correct length.", "A balanced ratio of proteins from gene G and frameshift-extended gene GT is req...

[ 1993, 2014, 2013 ]

3

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 1888, 66, 25 ]

3

[]

0

true

Domain

Minor tail T

Phage_tail_T

1

IPR009351

9,351

DNA glycosylase AlkZ-like

AlkZ-like

Family

21,353

false

This protein family includes Interstrand DNA cross-link repair glycosylase (YcaQ) from Escherichia coli, AlkZ from Streptomyces sahachiroi (also known as Azi36), and similar proteins predominantly found in bacteria. YcaQ is a DNA glycosylase that protects cells against the toxicity of agents causing interstrand DNA cro...

[]

0

[ "PFAM" ]

[ "PF06224" ]

[ "AlkZ-like" ]

[ 21353 ]

1

[]

0

[ "5uuj" ]

1

[ "PUB00100682", "PUB00100683" ]

[ "28396405", "32409837" ]

[ "Structure of a DNA glycosylase that unhooks interstrand cross-links.", "Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks." ]

[ 2017, 2020 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 50, 21109, 21, 173 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA glycosylase AlkZ-like

AlkZ-like

3

IPR009353

9,353

Orthopoxvirus, Protein N1

Orthopox_N1

Family

63

false

This family represents Protein N1 and similar proteins from the genus Orthopoxvirus. N1 is a Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B [ , ].

[ "GO:0052031", "GO:0052150" ]

[ "symbiont-mediated perturbation of host defense response", "symbiont-mediated perturbation of host apoptosis" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF003784" ]

[ "VAC_N1L" ]

[ 63 ]

1

[]

0

[ "2i39", "2uxe", "4bbb", "4bbc", "4bbd", "8xy1", "8xy2", "8xy3", "8xy4" ]

9

[ "PUB00049498", "PUB00062445" ]

[ "17485524", "22194685" ]

[ "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.", "Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence." ]

[ 2007, 2011 ]

2

[ "IPR022819" ]

[]

1

0

1

[ "Orthopoxvirus" ]

[ 63 ]

1

[]

0

true

Family

Orthopoxvirus, Protein N1

Orthopox_N1

4

IPR009354

9,354

Usg-like

Usg

Family

1,961

false

This is a family of bacterial proteins, referred to as Usg. Usg is found in the same operon as trpF, trpB, and trpA and is expressed in a coupled transcription-translation system [ ].

[]

0

[ "PFAM" ]

[ "PF06233" ]

[ "Usg" ]

[ 1961 ]

1

[]

0

[]

0

[ "PUB00012296" ]

[ "2828322" ]

[ "Structure of the Caulobacter crescentus trpFBA operon." ]

[ 1988 ]

1

[]

0

null

[ "Bacteria", "Marine Group I thaumarchaeote", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 1947, 3, 10, 1 ]

4

[]

0

true

Family

Usg-like

Usg

6

IPR009355

9,355

Toluene-4-monooxygenase system B

Toluene_mOase_B

Family

285

false

This family includes several toluene-4-monooxygenase system ( ) protein B (TmoB) sequences. Pseudomonas mendocina KR1 metabolises toluene as a carbon source. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system [ ]. Also included in the f...

[]

0

[ "PFAM" ]

[ "PF06234" ]

[ "TmoB" ]

[ 285 ]

1

[]

0

[ "1t0q", "1t0r", "1t0s", "2inc", "2ind", "2rdb", "3dhg", "3dhh", "3dhi", "3ge3", "3ge8", "3i5j", "3i63", "3n1x", "3n1y", "3n1z", "3n20", "3q14", "3q2a", "3q3m", "3q3n", "3q3o", "3ri7", "3rmk", "3rn9", "3rna", "3rnb", "3rnc", "3rne", "3rnf", "3rng", "4p1b"...

37

[ "PUB00012297", "PUB00088050" ]

[ "1885512", "9312093" ]

[ "Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.", "Alkene monooxygenase from Xanthobacter strain Py2. Purification and characterization of a four-component system central to the bacterial metabolism of aliphatic alkenes." ]

[ 1991, 1997 ]

2

[]

0

null

[ "Bacteria", "Halobacteriales", "ecological metagenomes" ]

[ 273, 3, 9 ]

3

[]

0

true

Family

Toluene-4-monooxygenase system B

Toluene_mOase_B

3

IPR009356

9,356

NADH dehydrogenase subunit 4L

NAD_DH_su4L

Family

402

false

This family consists of NADH dehydrogenase subunit 4L (NAD4L) proteins from the mitochondria of several parasitic flatworms.

[]

0

[ "PFAM" ]

[ "PF06235" ]

[ "NAD4L" ]

[ 402 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Lophotrochozoa", "Metamycoplasma phocicerebrale" ]

[ 401, 1 ]

2

[]

0

true

Family

NADH dehydrogenase subunit 4L

NAD_DH_su4L

8

IPR009357

9,357

Solute carrier family 52, riboflavin transporter

Riboflavin_transptr

Family

3,797

false

This entry includes a group of animal riboflavin transporters, including SLC52A1, SLC52A2 and SLC52A3 from humans which belong to the MFS superfamily [ , ]. They are plasma membrane proteins that transport vitamin B2 (riboflavin, RF) into cells [ ]. In case of infection by retroviruses, they act as cell receptors to re...

[ "GO:0032217", "GO:0032218", "GO:0005886" ]

[ "riboflavin transmembrane transporter activity", "riboflavin transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06237", "PTHR12929" ]

[ "SLC52_ribofla_tr", "" ]

[ 3791, 3671 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-196843", "R-CEL-196843", "R-DRE-196843", "R-HSA-196843", "R-MMU-196843", "R-RNO-196843" ]

[ "REACTOME:R-BTA-196843", "REACTOME:R-CEL-196843", "REACTOME:R-DRE-196843", "REACTOME:R-HSA-196843", "REACTOME:R-MMU-196843", "REACTOME:R-RNO-196843" ]

6

[ "8xsm", "8xsn" ]

2

[ "PUB00078058", "PUB00078059", "PUB00103551", "PUB00103552", "PUB00103553", "PUB00103554" ]

[ "19307586", "25284511", "27702554", "24253200", "36164651", "23506902" ]

[ "Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor.", "Identification and characterization of 5'-flanking region of the human riboflavin transporter 1 gene (SLC52A1).", "SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian ...

[ 2009, 2014, 2016, 2014, 2022, 2013 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3797 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 12, 2, 23, 2, 10 ]

6

true

Family

Solute carrier family 52, riboflavin transporter

Riboflavin_transptr

8

IPR009359

9,359

1,2-phenylacetyl-CoA epoxidase, subunit B

PaaB

Family

6,748

false

This entry represents the 1,2-phenylacetyl-CoA epoxidase, subunit B (also known as PaaB) and related bacterial proteins. Phenylacetyl-CoA monooxygenase (epoxidase) is a multicomponent enzyme, PaaABC(D)E, responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (P...

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF06243", "PIRSF030200", "TIGR02157" ]

[ "PaaB", "PaaB", "PA_CoA_Oxy2" ]

[ 6748, 5417, 5995 ]

3

[]

0

[ "3egr", "4iit" ]

2

[ "PUB00005820", "PUB00010200", "PUB00055817", "PUB00075378", "PUB00088285" ]

[ "9600981", "9748275", "21247899", "20660314", "22398448" ]

[ "Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon.", "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway.", "Structural and functional studies of the Escherichia coli phenylacetyl-CoA ...

[ 1998, 1998, 2011, 2010, 2012 ]

5

[]

[ "IPR023976" ]

0

1

0

[ "Bacteria", "Darwinula stevensoni", "Halobacteriales", "unclassified sequences" ]

[ 6372, 1, 330, 45 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

1,2-phenylacetyl-CoA epoxidase, subunit B

PaaB

8

IPR009360

9,360

Pre-mRNA-splicing factor Isy1

Isy1

Family

5,682

false

This entry includes yeast Isy1 and it's homologues from plants and animals. In budding yeast, Isy1 is part of the NineTeen Complex (NTC), which is involved in spliceosome activation by specifying the interaction of U5 and U6 with pre-mRNA for their stable association with the spliceosome after U4 dissociation [ ]. The ...

[ "GO:0000350" ]

[ "generation of catalytic spliceosome for second transesterification step" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06246", "PTHR13021" ]

[ "Isy1", "" ]

[ 5681, 5288 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-72163", "R-DDI-6781823", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-72163", "R-HSA-6781823", "R-HSA-6781827", "R-HSA-6782135", "R-HSA-6782210", "R-HSA-72163", "R-MMU-6781823", "R-MMU-6782135", "R-MMU-6782210", "R-MMU-72163", "...

[ "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-72163", "REACTOME:R-DDI-6781823", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-72163", "REACTOME:R-HSA-6781823", "REACTOME:R-HSA-6781827", "REACTOME:R-HSA-6782135", "REACTOME:R-...

28

[ "1x4t", "5gmk", "5lj3", "5lj5", "5yzg", "6ff7", "6j6g", "6j6h", "6j6n", "6j6q", "6zym", "7a5p", "7b9v", "8c6j", "8ch6", "8i0w", "8ro0", "8ro1", "8ro2", "9dtr", "9fmd", "9l5s" ]

22

[ "PUB00084341" ]

[ "16540691" ]

[ "Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5682 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 2, 5, 6, 1, 4, 7, 1, 1, 17 ]

12

true

Family

Pre-mRNA-splicing factor Isy1

Isy1

6

IPR009361

9,361

Centromere/kinetochore protein zw10, N-terminal

Zw10_N

Domain

1,968

false

This domain is found N-terminal in homologues of Centromere/kinetochore protein ZW10. Zeste white 10 (ZW10) was initially identified as a mitotic checkpoint protein involved in chromosome segregation, and then implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, but it is also important in n...

[ "GO:0000278", "GO:0000775", "GO:0005634" ]

[ "mitotic cell cycle", "chromosome, centromeric region", "nucleus" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06248" ]

[ "Zw10_N" ]

[ 1968 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-6811434", "R-DME-6811434", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-6811434", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-6811434", "R-MMU-68877", "R-MMU-9648025", "R-RNO-141444", ...

[ "REACTOME:R-CEL-6811434", "REACTOME:R-DME-6811434", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-...

23

[ "7qpg" ]

1

[ "PUB00013411", "PUB00044109", "PUB00044110", "PUB00044111", "PUB00044112", "PUB00044113", "PUB00100050" ]

[ "11146659", "17102640", "16505164", "17576797", "18268100", "17509882", "22685323" ]

[ "Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.", "ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?", "Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function.", "Spi...

[ 2000, 2006, 2006, 2007, 2008, 2007, 2012 ]

7

[]

0

null

[ "Eukaryota" ]

[ 1968 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 1, 3, 4, 1, 2 ]

7

true

Domain

Centromere/kinetochore protein zw10, N-terminal

Zw10_N

2

IPR009362

9,362

YhcG PDDEXK nuclease domain

YhcG_C

Domain

8,708

false

This domain can be found in uncharacterised proteins in viruses, archaea and bacteria, most notably it is found in YhcG protein from E.coli. This entry represents the C-terminal PDDEXK domain belonging to the PD-(D/E)XK superfamily of nucleases involved in DNA recombination and repair [ ]. Profile HMM analysis identifi...

[]

0

[ "PFAM" ]

[ "PF06250" ]

[ "YhcG_C" ]

[ 8708 ]

1

[]

0

[]

0

[ "PUB00054003", "PUB00091061" ]

[ "16011798", "19402753" ]

[ "The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional predictions for domains of (hitherto) unknown function.", "Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins." ]

[ 2005, 2009 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 136, 8374, 18, 4, 176 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YhcG PDDEXK nuclease domain

YhcG_C

7

IPR009363

9,363

Bacteriophage Mu, Gp16

Phage_Mu_Gp16

Family

2,401

false

This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably co...

[]

0

[ "PFAM" ]

[ "PF06252" ]

[ "GemA" ]

[ 2401 ]

1

[]

0

[]

0

[ "PUB00097481" ]

[ "11278077" ]

[ "The GemA protein of phage Mu and the GyrB gyrase subunit of Escherichia coli: the search for targets and interactions leading to the reversion of Mu-induced mutations." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Cuniculiplasma divulgatum", "Opisthokonta", "Viruses", "metagenomes" ]

[ 2295, 2, 3, 81, 20 ]

5

[]

0

true

Family

Bacteriophage Mu, Gp16

Phage_Mu_Gp16

6

IPR009364

9,364

YdaT-like

Family

1,678

false

YdaT is a transcriptional regulator whose expression significantly impairs bacterial growth and cell viability. It disrupts the expression of multiple regulons normally governed by RcsA, leading to defects in lipopolysaccharide biosynthesis and cell division. While YdaT has no impact on Rac prophage excision, its overe...

[]

0

[ "PFAM" ]

[ "PF06254" ]

[ "YdaT_toxin" ]

[ 1678 ]

1

[]

0

[ "3c4r", "8bt1" ]

2

[ "PUB00075651", "PUB00099919", "PUB00160759", "PUB00160760" ]

[ "21927020", "29205229", "29205228", "38153127" ]

[ "Regulation of growth and death in Escherichia coli by toxin-antitoxin systems.", "CRISPR-Cas-Mediated Gene Silencing Reveals RacR To Be a Negative Regulator of YdaS and YdaT Toxins in <i>Escherichia coli</i> K-12.", "Repression of YdaS Toxin Is Mediated by Transcriptional Repressor RacR in the Cryptic <i>rac</...

[ 2011, 2017, 2017, 2024 ]

4

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "organismal metagenomes" ]

[ 1665, 2, 8, 3 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

YdaT-like

4

IPR009365

9,365

Nucleopolyhedrovirus LEF-12

Nucleo_LEF-12

Family

71

false

This family consists of several Nucleopolyhedrovirus late expression factor-12 (LEF-12) proteins. The function of this family is unknown [ , ].

[]

0

[ "PFAM" ]

[ "PF06256" ]

[ "Nucleo_LEF-12" ]

[ 71 ]

1

[]

0

[]

0

[ "PUB00013412", "PUB00013413" ]

[ "10814576", "12414945" ]

[ "Identification and molecular characterization of the Choristoneura fumiferana multicapsid nucleopolyhedrovirus genomic region encoding the regulatory genes pkip, p47, lef-12, and gta.", "Baculovirus lef-12 is not required for viral replication." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Alphabaculovirus" ]

[ 71 ]

1

[]

0

true

Family

Nucleopolyhedrovirus LEF-12

Nucleo_LEF-12

2

IPR009366

9,366

Protein Veg

Protein_Veg

Family

3,506

false

VEG protein is highly conserved among Gram-positive bacteria. It stimulates biofilm formation through inducing transcription of the tapA-sipW-tasA operon. The products of this operon are responsible for production of the amyloid fibre (TasA) component of the biofilm. Veg or a Veg-induced protein acts as an antirepresso...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06257", "PIRSF037257", "PTHR40026" ]

[ "VEG", "DUF1021", "" ]

[ 3506, 3010, 3459 ]

3

[]

0

[ "3fb9" ]

1

[ "PUB00070838", "PUB00070839" ]

[ "12761295", "23378512" ]

[ "Transcriptional, functional and cytochemical analyses of the veg gene in Bacillus subtilis.", "Functional analysis of the protein Veg, which stimulates biofilm formation in Bacillus subtilis." ]

[ 2003, 2013 ]

2

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 3487, 1, 18 ]

3

[]

0

true

Family

Protein Veg

Protein_Veg

4

IPR009367

9,367

Mitochondrial fission protein ELM1-like

Elm1-like

Family

4,094

false

In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites [ ]. Its function in bacteria is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06258", "PTHR33986" ]

[ "Mito_fiss_Elm1", "" ]

[ 4010, 3013 ]

2

[]

0

[]

0

[ "PUB00057490" ]

[ "18559960" ]

[ "Arabidopsis ELONGATED MITOCHONDRIA1 is required for localization of DYNAMIN-RELATED PROTEIN3A to mitochondrial fission sites." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2496, 1532, 66 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 7, 21 ]

3

true

Family

Mitochondrial fission protein ELM1-like

Elm1-like

1

IPR009368

9,368

Protein of unknown function DUF1024

DUF1024

Family

221

false

This family consists of several hypothetical proteins, mainly Staphylococcus aureus phage phi proteins which are related to Orf64 from Staphylococcus phage 92 (Bacteriophage 92). The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06260" ]

[ "DUF1024" ]

[ 221 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 107, 114 ]

2

[]

0

true

Family

Protein of unknown function DUF1024

DUF1024

3

IPR009370

9,370

YutD-like

Family

3,045

false

This family contains a group of uncharacterised bacterial proteins, including YutD from Bacillus subtilis (PDBe:2kl5), a probable antitoxin component of a putative type VII toxin-antitoxin (TA) system, that probably neutralizes cognate toxin YutE.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06265", "PIRSF012565" ]

[ "YutD-like", "DUF1027" ]

[ 3045, 2537 ]

2

[]

0

[ "2kl5" ]

1

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3043, 2 ]

2

[]

0

true

Family

YutD-like

7

IPR009371

9,371

Type III secretion protein HrpF

T3SS_HrpF

Family

319

false

The species Pseudomonas syringae encompasses plant pathogens with differing host specificities and corresponding pathovar designations. P. syringae requires the Hrp (type III protein secretion) system, encoded by a 25-kb cluster of hrp and hrc genes, in order to elicit the hypersensitive response (HR) in nonhosts or to...

[]

0

[ "PFAM" ]

[ "PF06266" ]

[ "HrpF" ]

[ 319 ]

1

[]

0

[]

0

[ "PUB00012305" ]

[ "9721291" ]

[ "Characterization of the hrpC and hrpRS operons of Pseudomonas syringae pathovars syringae, tomato, and glycinea and analysis of the ability of hrpF, hrpG, hrcC, hrpT, and hrpV mutants to elicit the hypersensitive response and disease in plants." ]

[ 1998 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Pseudomonadota" ]

[ 1, 318 ]

2

[]

0

true

Family

Type III secretion protein HrpF

T3SS_HrpF

2

IPR009372

9,372

Poxvirus virion membrane protein A14.5

Poxvirus_A14.5

Family

75

false

This is a family of Poxvirus proteins. It includes virion membrane protein A14.5 from Vaccinia virus, also known as Virion membrane protein OPG141, which has been shown to enhance virulence in mice [ ].

[]

0

[ "PFAM" ]

[ "PF06269" ]

[ "DUF1029" ]

[ 75 ]

1

[]

0

[]

0

[ "PUB00078099" ]

[ "10756020" ]

[ "The vaccinia virus A14.5L gene encodes a hydrophobic 53-amino-acid virion membrane protein that enhances virulence in mice and is conserved among vertebrate poxviruses." ]

[ 2000 ]

1

[]

0

null

[ "Chordopoxvirinae" ]

[ 75 ]

1

[]

0

true

Family

Poxvirus virion membrane protein A14.5

Poxvirus_A14.5

4

IPR009373

9,373

Circovirus 2, Orf5

Circovirus2_Orf5

Family

10

false

This family consists of several short Circovirus proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06270" ]

[ "DUF1030" ]

[ 10 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Porcine circovirus 2" ]

[ 10 ]

1

[]

0

true

Family

Circovirus 2, Orf5

Circovirus2_Orf5

4

IPR009374

9,374

Eukaryotic translation initiation factor 3 subunit K

eIF3k

Family

4,356

false

Eukaryotic translation initiation factor 3 subunit K is a Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [ , ].

[ "GO:0003743", "GO:0005737", "GO:0005852" ]

[ "translation initiation factor activity", "cytoplasm", "eukaryotic translation initiation factor 3 complex" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "HAMAP", "PANTHER" ]

[ "MF_03010", "PTHR13022" ]

[ "eIF3k", "" ]

[ 3665, 4312 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-CEL-156827", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "...

39

[ "1rz4", "3j8b", "3j8c", "5a5t", "6fec", "6w2s", "6w2t", "6yam", "6ybd", "6zmw", "6zon", "6zp4", "6zvj", "7a09", "7ase", "7qp6", "7qp7", "8oz0", "8pj1", "8pj2", "8pj3", "8pj4", "8pj5", "8pj6", "8ppl", "8rg0", "8xxn", "9bln", "9cpa" ]

29

[ "PUB00005773", "PUB00010248" ]

[ "8995409", "11042177" ]

[ "Conservation and diversity of eukaryotic translation initiation factor eIF3.", "Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4355, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 2, 1, 9, 3, 1, 1, 9, 18 ]

10

true

Family

Eukaryotic translation initiation factor 3 subunit K

eIF3k

4

IPR009376

9,376

Protein of unknown function DUF1031

DUF1031

Family

81

false

This family of uncharacterised proteins is found mostly in Lactococcus species and their bacteriophages.

[]

0

[ "PFAM" ]

[ "PF06275" ]

[ "DUF1031" ]

[ 81 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Lactobacillales" ]

[ 9, 72 ]

2

[]

0

true

Family

Protein of unknown function DUF1031

DUF1031

4

IPR009377

9,377

Ethanolamine ammonia-lyase reactivase EutA

EutA

Family

2,321

false

Proteins in this entry are EutA ethanolamine utilization proteins, reactivating factors for ethanolamine ammonia lyase, encoded by the ethanolamine utilization eut operon [ ]. The holoenzyme of adenosylcobalamin-dependent ethanolamine ammonia-lyase (EutBC, , ), which is part of the ethanolamine utilization pathway [ , ...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06277", "PIRSF012293" ]

[ "EutA", "EutA" ]

[ 2321, 1989 ]

2

[ "GP" ]

[ "GenProp0292" ]

[ "GP:GenProp0292" ]

1

[]

0

[ "PUB00009955", "PUB00013593", "PUB00014696", "PUB00027782", "PUB00035324" ]

[ "10464203", "11160088", "2656649", "15466038", "15516577" ]

[ "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.", "Functions required for vitamin B12-dependent etha...

[ 1999, 2001, 1989, 2004, 2004 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Capitella teleta", "unclassified sequences" ]

[ 38, 2240, 1, 42 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ethanolamine ammonia-lyase reactivase EutA

EutA

4

IPR009378

9,378

Condensin II complex subunit H2, N-terminal

H2_N

Domain

2,336

false

This entry represents the N-terminal domain of the H2 subunit of the condensing II complex, found in eukaryotes but not in fungi.

[]

0

[ "PFAM" ]

[ "PF06278" ]

[ "CNDH2_N" ]

[ 2336 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2299718", "R-CEL-2299718", "R-DRE-2299718", "R-HSA-2299718", "R-MMU-2299718", "R-RNO-2299718" ]

[ "REACTOME:R-BTA-2299718", "REACTOME:R-CEL-2299718", "REACTOME:R-DRE-2299718", "REACTOME:R-HSA-2299718", "REACTOME:R-MMU-2299718", "REACTOME:R-RNO-2299718" ]

6

[ "9f5w" ]

1

[ "PUB00056005", "PUB00075710" ]

[ "20442714", "22855829" ]

[ "Condensin and cohesin complexity: the expanding repertoire of functions.", "Condensins: universal organizers of chromosomes with diverse functions." ]

[ 2010, 2012 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2335, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 4, 5, 3, 4, 5, 11 ]

8

true

Domain

Condensin II complex subunit H2, N-terminal

H2_N

5

IPR009379

9,379

Structural protein VP1/VP3

VP1_VP3

Family

42

false

Sulfolobus virus-like particle SSV1 and its fusellovirus homologues can be found in many acidic (pH less than 4.0) hot springs (greater than 70 degrees C) around the world. SSV1 contains a 15.5-kb double-stranded DNA genome that encodes 34 proteins with greater than 50 amino acids [ ]. A site-specific integrase and a D...

[ "GO:0005198", "GO:0016020" ]

[ "structural molecule activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06281" ]

[ "VP1_VP3" ]

[ 42 ]

1

[]

0

[ "7xdi" ]

1

[ "PUB00014897" ]

[ "1926776" ]

[ "Complete nucleotide sequence of the virus SSV1 of the archaebacterium Sulfolobus shibatae." ]

[ 1991 ]

1

[]

0

null

[ "Fuselloviridae", "Sulfolobaceae" ]

[ 22, 20 ]

2

[]

0

true

Family

Structural protein VP1/VP3

VP1_VP3

8

IPR009380

9,380

Protein of unknown function DUF1036

DUF1036

Family

1,927

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06282" ]

[ "DUF1036" ]

[ 1927 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina barkeri (strain Fusaro / DSM 804)", "ecological metagenomes" ]

[ 1909, 4, 1, 13 ]

4

[]

0

true

Family

Protein of unknown function DUF1036

DUF1036

1

IPR009381

9,381

Trehalose catabolism protein, ThuA, prokaryote

Trehalose_catabolism_ThuA_prok

Family

3,301

false

This family consists of several bacterial thuA like proteins, including thuA from Sinorhizobium meliloti ( ) [ ]. The S. meliloti thuA gene is part of the thu operon (thuEFGKAB) that codes for transport and utilization functions of the disaccharide trehalose. ThuA is an enzyme(s) involved in the conversion of disacchar...

[]

0

[ "PIRSF" ]

[ "PIRSF030013" ]

[ "ThuA" ]

[ 3301 ]

1

[]

0

[ "1t0b" ]

1

[ "PUB00076441", "PUB00076443" ]

[ "23772075", "16042015" ]

[ "The thuEFGKAB operon of rhizobia and agrobacterium tumefaciens codes for transport of trehalose, maltitol, and isomers of sucrose and their assimilation through the formation of their 3-keto derivatives.", "Role of trehalose transport and utilization in Sinorhizobium meliloti--alfalfa interactions." ]

[ 2013, 2005 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "unclassified sequences" ]

[ 2971, 317, 13 ]

3

[]

0

true

Family

Trehalose catabolism protein, ThuA, prokaryote

Trehalose_catabolism_ThuA_prok

6

IPR009382

9,382

Coleoptericin

Family

107

false

This family consists of several insect coleoptericin, acaloleptin, holotricin and rhinocerosin proteins which are all known to be antibacterial proteins [ ]. These all appear to be short, glycine-rich molecules, inducible by infection.

[ "GO:0042742", "GO:0005576" ]

[ "defense response to bacterium", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06286" ]

[ "Coleoptericin" ]

[ 107 ]

1

[]

0

[]

0

[ "PUB00012308" ]

[ "11520352" ]

[ "Purification, characterization and gene expression of a glycine and proline-rich antibacterial protein family from larvae of a beetle, Allomyrina dichotoma." ]

[ 2001 ]

1

[]

0

null

[ "Endopterygota" ]

[ 107 ]

1

[]

0

true

Family

Coleoptericin

4

IPR009383

9,383

Protein of unknown function DUF1040

DUF1040

Family

1,597

false

This family consists of several bacterial YihD proteins of unknown function [ ].

[]

0

[ "PFAM" ]

[ "PF06288" ]

[ "DUF1040" ]

[ 1597 ]

1

[]

0

[ "2ko6" ]

1

[ "PUB00009964" ]

[ "9868784" ]

[ "Small genes/gene-products in Escherichia coli K-12." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Halosegnis longus", "Opisthokonta", "human gut metagenome" ]

[ 1592, 1, 3, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1040

DUF1040

4

IPR009384

9,384

Swarming motility protein SwrD-like

SwrD-like

Family

3,219

false

Bacillus subtilis SwrD increases flagellar torque and is necessary for swarming [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06289", "PTHR39185" ]

[ "FlbD", "" ]

[ 3219, 3137 ]

2

[]

0

[]

0

[ "PUB00088307" ]

[ "29061663" ]

[ "SwrD (YlzI) Promotes Swarming in Bacillus subtilis by Increasing Power to Flagellar Motors." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Sar", "metagenomes" ]

[ 3177, 6, 2, 34 ]

4

[]

0

true

Family

Swarming motility protein SwrD-like

SwrD-like

5

IPR009386

9,386

Z-ring associated protein G-like

ZapG-like

Family

3,384

false

This entry represents Z-ring associated protein G from Escherichia coli (ZapG) and similar proteins predominantly found in gammaproteobacteria. ZapG is involved in cell division, cell envelope biogenesis and cell shape maintenance. It is a key regulator of cell envelope growth, playing a crucial role in coordinating ce...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06295", "PIRSF006318", "PTHR39579" ]

[ "ZapG-like", "YhcB", "" ]

[ 3384, 2301, 3158 ]

3

[]

0

[ "6un9" ]

1

[ "PUB00104752", "PUB00151520", "PUB00151521", "PUB00151522", "PUB00151523" ]

[ "33895137", "27335665", "32323199", "34941903", "36077106" ]

[ "ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis.", "Inner Membrane Protein YhcB Interacts with RodZ Involved in Cell Shape Maintenance in Escherichia coli.", "Phenotypic characterization of a conserved inner membrane protein YhcB i...

[ 2021, 2012, 2020, 2021, 2022 ]

5

[]

0

null

[ "Bacteria", "Neoptera", "metagenomes" ]

[ 3364, 2, 18 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Z-ring associated protein G-like

ZapG-like

1

IPR009387

9,387

Toxin HigB-2

HigB-2

Family

5,934

false

Bacterial toxin-antitoxin loci consist of two genes in an operon encoding a 'toxin' and an 'antitoxin' respectively. Ectopic expression of the toxins severely reduces cell growth and prevents colony formation. This entry includes HigB-2, one of the toxins found in Vibrio cholerae. It inhibits translation by cleavage of...

[]

0

[ "PFAM", "PIRSF", "PIRSF" ]

[ "PF06296", "PIRSF018634", "PIRSF039032" ]

[ "RelE", "UCP018634", "HigB-2" ]

[ 4279, 1697, 3498 ]

3

[]

0

[ "5ja8", "5ja9", "5jaa", "5mje", "8a0x" ]

5

[ "PUB00063680", "PUB00076680" ]

[ "17020579", "17085558" ]

[ "Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids.", "Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae." ]

[ 2006, 2007 ]

2

[]

0

null

[ "Bacteria", "Methanosarcinales", "Opisthokonta", "Siphoviridae sp. ctpbe1", "unclassified sequences" ]

[ 5865, 3, 8, 1, 57 ]

5

[]

0

true

Family

Toxin HigB-2

HigB-2

3

IPR009388

9,388

Photosystem II PsbY

PSII_PsbY

Family

1,541

false

This family represents the low molecular weight transmembrane protein PsbY found in PSII. In higher plants, two related PsbY proteins exist, PsbY-1 and PsbY-2, which appear to function as a heterodimer. In spinach and Arabidopsis, these two proteins arise from a single-copy nuclear gene that is processed in the chlorop...

[ "GO:0030145", "GO:0015979", "GO:0009523", "GO:0016020" ]

[ "manganese ion binding", "photosynthesis", "photosystem II", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "HAMAP", "PFAM" ]

[ "MF_00717", "PF06298" ]

[ "PSII_PsbY", "PsbY" ]

[ 1458, 1537 ]

2

[ "GP" ]

[ "GenProp0661" ]

[ "GP:GenProp0661" ]

1

[ "4il6", "4pj0", "4ub6", "4ub8", "5gth", "5gti", "5kaf", "5kai", "5mx2", "5tis", "5ws5", "5ws6", "6dhe", "6dhf", "6dhg", "6dhh", "6dho", "6dhp", "6jlj", "6jlk", "6jll", "6jlm", "6jln", "6jlo", "6jlp", "6jlu", "6w1o", "6w1p", "6w1q", "6w1r", "6w1t", "6w1u"...

88

[ "PUB00012313", "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015379", "PUB00097583", "PUB00152828" ]

[ "9829828", "12518057", "15100025", "14871485", "15042356", "30076221", "33846594" ]

[ "PsbY, a novel manganese-binding, low-molecular-mass protein associated with photosystem II.", "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement of photosystem 2.", "The low molecular mass subun...

[ 1998, 2003, 2004, 2004, 2004, 2018, 2021 ]

7

[]

[ "IPR038760" ]

0

1

0

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 352, 1188, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 6 ]

3

true

Family

Photosystem II PsbY

PSII_PsbY

3

IPR009389

9,389

Protein of unknown function DUF1045

DUF1045

Family

2,604

false

This family consists of several hypothetical proteins from Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF06299", "PIRSF033328", "TIGR03223" ]

[ "DUF1045", "Phest_Mll4975", "Phn_opern_protn" ]

[ 2604, 2286, 1379 ]

3

[ "GP" ]

[ "GenProp0232" ]

[ "GP:GenProp0232" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2581, 15, 8 ]

3

[]

0

true

Family

Protein of unknown function DUF1045

DUF1045

7

IPR009390

9,390

Macrodomain Ter protein, MatP

MatP

Family

1,622

false

This entry contains MatP (YcbG), which is a component of the MatP/MatS site-specific system that organises the Ter macrodomain (MD) in Escherichia coli (strain K12) and related enterobacteria during replication of the chromosome. In E. coli there are 23 matS sequences, located in the Ter region which is centred on dif....

[ "GO:0043565" ]

[ "sequence-specific DNA binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01073", "NF003471" ]

[ "MatP", "PRK05097.1" ]

[ 1604, 1622 ]

2

[]

0

[ "3vea", "3veb", "4d8j", "7nyw", "7nyx", "7nyz", "7nz0", "7nz2", "7nz3" ]

9

[ "PUB00053963", "PUB00053964", "PUB00053965", "PUB00053966", "PUB00053967" ]

[ "16860572", "14685268", "7877981", "17020576", "18984159" ]

[ "Chromosome organization and segregation in bacteria.", "migS, a cis-acting site that affects bipolar positioning of oriC on the Escherichia coli chromosome.", "The dif resolvase locus of the Escherichia coli chromosome can be replaced by a 33-bp sequence, but function depends on location.", "The Escherichia ...

[ 2006, 2004, 1995, 2006, 2008 ]

5

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1620, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Macrodomain Ter protein, MatP

MatP

2

IPR009391

9,391

23S rRNA methylase leader peptide

ErmCL

Family

179

false

This family consists of several very short bacterial 23S rRNA methylase leader peptide (ErmCL) sequences. ermC confers resistance to macrolide-lincosamide streptogramin B antibiotics by specifying a ribosomal RNA methylase, which results in decreased ribosomal affinity for these antibiotics. ermC expression is induced ...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06308" ]

[ "ErmC" ]

[ 179 ]

1

[]

0

[]

0

[ "PUB00012317", "PUB00091060" ]

[ "4018035", "28369621" ]

[ "Induction of ermC requires translation of the leader peptide.", "Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain." ]

[ 1985, 2017 ]

2

[]

0

null

[ "Bacteria", "Plasmid pIlo8" ]

[ 178, 1 ]

2

[]

0

true

Family

23S rRNA methylase leader peptide

ErmCL

8

IPR009392

9,392

Drosophila ACP53EA

ACP53EA

Family

225

false

This family consists of several Drosophila ACP53EA accessory gland (seminal) proteins [ ].

[]

0

[ "PFAM" ]

[ "PF06313" ]

[ "ACP53EA" ]

[ 225 ]

1

[]

0

[]

0

[ "PUB00019093" ]

[ "11102381" ]

[ "Molecular population genetics of male accessory gland proteins in Drosophila." ]

[ 2000 ]

1

[]

0

null

[ "Drosophilinae" ]

[ 225 ]

1

[ "Drosophila melanogaster" ]

[ 14 ]

1

true

Family

Drosophila ACP53EA

ACP53EA

9

IPR009394

9,394

DNA repair protein MmcB-like

MmcB-like

Family

2,738

false

Proteins in this entry include MmcB ( ) from Caulobacter crescentus. MmcB is required specifically for MMC-induced mutagenesis. Based on the structural analysis of a close homologue, MmcB is predicted to be an endonuclease [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06319", "PIRSF031796" ]

[ "MmcB-like", "UPC031796" ]

[ 2738, 2376 ]

2

[]

0

[ "3dnx" ]

1

[ "PUB00077771" ]

[ "26162909" ]

[ "Functional characterization of two SOS-regulated genes involved in mitomycin C resistance in Caulobacter crescentus." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2658, 3, 32, 45 ]

4

[]

0

true

Family

DNA repair protein MmcB-like

MmcB-like

4

IPR009395

9,395

Biogenesis of lysosome-related organelles complex 1 subunit 1

BLOC1S1

Family

3,017

false

GCN5L1 (general control of amino acid synthesis 5-like 1), also known as BLOC1S1 (biogenesis of lysosome-related organelles complex 1 subunit 1). It is a component of the BLOC-1 complex, a complex required for normal biogenesis of lysosome-related organelles [ ]. GCN5L1 has been identified as a critical component of th...

[ "GO:0031083" ]

[ "BLOC-1 complex" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR13073" ]

[ "" ]

[ 3017 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

230

[]

0

[ "PUB00043622", "PUB00075401", "PUB00075402" ]

[ "17182842", "22309213", "24356961" ]

[ "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.", "Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.", "GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinate...

[ 2007, 2012, 2014 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3017 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 2, 7, 3, 1, 11, 5, 7 ]

10

true

Family

Biogenesis of lysosome-related organelles complex 1 subunit 1

BLOC1S1

7

IPR009396

9,396

Pigment-dispersing hormone

Pigment_DH

Family

275

false

This family consists of several eukaryotic pigment-dispersing hormone (PDH) proteins. The pigment-dispersing hormone (PDH) is produced in the eyestalks of Crustacea where it induces light-adapting movements of pigment in the compound eye and regulates the pigment dispersion in the chromatophores [ ].

[ "GO:0005179", "GO:0009416", "GO:0005576" ]

[ "hormone activity", "response to light stimulus", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06324" ]

[ "Pigment_DH" ]

[ 275 ]

1

[]

0

[]

0

[ "PUB00012324" ]

[ "8477858" ]

[ "Structure and localization of mRNA encoding a pigment dispersing hormone (PDH) in the eyestalk of the crayfish Orconectes limosus." ]

[ 1993 ]

1

[]

0

null

[ "Brachyspira pilosicoli", "Panarthropoda" ]

[ 1, 274 ]

2

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Family

Pigment-dispersing hormone

Pigment_DH

1

IPR009397

9,397

Vesiculovirus matrix

Vesiculo_matrix

Family

413

false

This family consists of several Vesiculovirus matrix proteins. The matrix (M) protein of vesicular stomatitis virus (VSV) expressed in the absence of other viral components causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown...

[ "GO:0005198", "GO:0019031" ]

[ "structural molecule activity", "viral envelope" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06326" ]

[ "Vesiculo_matrix" ]

[ 413 ]

1

[]

0

[ "1lg7", "2w2r", "4owr", "7umk", "7uml", "7uws" ]

6

[ "PUB00012325" ]

[ "12692256" ]

[ "The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death." ]

[ 2003 ]

1

[]

0

null

[ "Riboviria" ]

[ 413 ]

1

[]

0

true

Family

Vesiculovirus matrix

Vesiculo_matrix

1

IPR009398

9,398

Adenylate cyclase, conserved domain

Adcy_conserved_dom

Domain

9,636

false

Cyclic AMP (cAMP) is a ubiquitous signalling molecule which mediates many cellular processes by activating cAMP-dependent kinases and also inducing protein-protein interactions. This molecule is produced by the adenylate cyclase (AC) enzyme, using ATP as its substrate. Mammalian adenylate cyclase has nine closely relat...

[ "GO:0004016", "GO:0006171", "GO:0005886" ]

[ "adenylate cyclase activity", "cAMP biosynthetic process", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06327" ]

[ "Adcy_cons_dom" ]

[ 9636 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "4.6.1.1", "R-DME-163615", "R-DME-170660", "R-DME-170670", "R-DME-5610787", "R-HSA-163359", "R-HSA-163615", "R-HSA-164378", "R-HSA-170660", "R-HSA-170670", "R-HSA-381676", "R-HSA-400042", "R-HSA-418555", "R-HSA-418594", "R-HSA-418597", "R-HSA-432040", "R-HSA-442720", "R-HSA-5610787...

[ "EC:4.6.1.1", "REACTOME:R-DME-163615", "REACTOME:R-DME-170660", "REACTOME:R-DME-170670", "REACTOME:R-DME-5610787", "REACTOME:R-HSA-163359", "REACTOME:R-HSA-163615", "REACTOME:R-HSA-164378", "REACTOME:R-HSA-170660", "REACTOME:R-HSA-170670", "REACTOME:R-HSA-381676", "REACTOME:R-HSA-400042", "R...

34

[ "8buz", "8bv5", "8sl3", "8sl4" ]

4

[ "PUB00034664", "PUB00034665", "PUB00034666" ]

[ "11264454", "12940771", "9417641" ]

[ "Regulation and role of adenylyl cyclase isoforms.", "Regulation and organization of adenylyl cyclases and cAMP.", "Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS." ]

[ 2001, 2003, 1997 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 9636 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 72, 15, 27, 18, 30 ]

5

true

Domain

Adenylate cyclase, conserved domain

Adcy_conserved_dom

3

IPR009400

9,400

TFIIH subunit TTDA/Tfb5

TFIIH_TTDA/Tfb5

Family

3,291

false

This entry represents TTDA/Tfb5 subunit of TFIIH basal transcription factor complex. These proteins have a structural motif consisting of a 2-layer sandwich structure with an α/β plait topology. Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms. Transcription/repa...

[ "GO:0006289", "GO:0006367", "GO:0000439" ]

[ "nucleotide-excision repair", "transcription initiation at RNA polymerase II promoter", "transcription factor TFIIH core complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER", "SMART" ]

[ "PF06331", "PTHR28580", "SM01395" ]

[ "Tfb5", "", "Tbf5" ]

[ 3283, 2885, 3262 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2048", "R-BTA-113418", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-72086", "R-BTA-73762", "R-BTA-73772", "R-BTA-73776", "R-BTA-73779", "R-BTA-73863", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042"...

[ "GP:GenProp2048", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-73762", "REACTOME:R-BTA-73772"...

145

[ "1ydl", "2jnj", "3dgp", "3dom", "5fmf", "5ivw", "5iy6", "5iy7", "5iy8", "5iy9", "5of4", "5oqj", "5oqm", "5sva", "6gym", "6nmi", "6o9l", "6o9m", "6ro4", "6trs", "7ad8", "7egb", "7egc", "7ena", "7enc", "7k01", "7k04", "7lbm", "7m2u", "7ml0", "7ml1", "7ml2"...

76

[ "PUB00035717", "PUB00062813" ]

[ "15220921", "21592869" ]

[ "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.", "A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor." ]

[ 2004, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3291 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 1, 1, 1, 1, 7, 3, 1, 1, 5 ]

12

true

Family

TFIIH subunit TTDA/Tfb5

TFIIH_TTDA/Tfb5

1

IPR009401

9,401

Mediator complex subunit Med13, C-terminal

Med13_C

Domain

6,685

false

This entry represents the C-terminal domain of Med13. This domain is also identified as an RNaseH domain of the medPIWI PIWI/Argonaute module. medPIWI is the core domain found in the Med13 protein. The medPIWI module in Med13 is predicted to bind double-stranded nucleic acids, triggering the experimentally-observed con...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06333" ]

[ "Med13_C" ]

[ 6685 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

6

[ "7kpv", "7kpx", "8t1l", "8t9d", "8tq2", "8tqc", "8tqw", "8trh" ]

8

[ "PUB00012328", "PUB00091016" ]

[ "12738880", "23758928" ]

[ "TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.", "Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes." ]

[ 2003, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6685 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 4, 4, 6, 1, 3, 8, 1, 1, 28 ]

12

true

Domain

Mediator complex subunit Med13, C-terminal

Med13_C

2

IPR009402

9,402

Orthopoxvirus A47

Orthopox_A47

Family

88

false

This family consists of several Orthopoxvirus A47 proteins. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06334" ]

[ "Orthopox_A47" ]

[ 88 ]

1

[]

0

[ "8gbe" ]

1

[]

0

[]

0

null

[ "Chordopoxvirinae" ]

[ 88 ]

1

[]

0

true

Family

Orthopoxvirus A47

Orthopox_A47

2

IPR009403

9,403

Protein of unknown function UPF0637

UPF0637

Family

2,242

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_01851", "PF06335", "PIRSF021332" ]

[ "UPF0637", "DUF1054", "DUF1054" ]

[ 1875, 2242, 1912 ]

3

[]

0

[ "2a8e", "3mqz" ]

2

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2238, 1, 3 ]

3

[]

0

true

Family

Protein of unknown function UPF0637

UPF0637

1

IPR009404

9,404

Coronavirus 5a

Corona_5a

Family

124

false

This family consists of several Coronavirus 5a proteins. The function of this family is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF06336" ]

[ "Corona_5a" ]

[ 124 ]

1

[]

0

[]

0

[ "PUB00008387" ]

[ "9168126" ]

[ "Sequence analysis of gene 3, gene 4 and gene 5 of avian infectious bronchitis virus strain CU-T2." ]

[ 1997 ]

1

[]

0

null

[ "Gammacoronavirus" ]

[ 124 ]

1

[]

0

true

Family

Coronavirus 5a

Corona_5a

6

IPR009405

9,405

Vibrio cholerae toxin co-regulated pilus biosynthesis F

TcpF

Family

13

false

This family consists of several Vibrio cholerae toxin co-regulated pilus biosynthesis protein F (TcpF) sequences. TcpF is known to be a secreted virulence protein but its exact function is unknown [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06340", "PIRSF020763" ]

[ "TcpF", "TcpF" ]

[ 13, 12 ]

2

[]

0

[ "3oc5", "3oc8", "7w65" ]

3

[ "PUB00012331" ]

[ "11466276" ]

[ "Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae." ]

[ 2001 ]

1

[]

0

null

[ "Vibrio" ]

[ 13 ]

1

[]

0

true

Family

Vibrio cholerae toxin co-regulated pilus biosynthesis F

TcpF

8

IPR009406

9,406

Protein of unknown function DUF1056

DUF1056

Family

241

false

This family consists of several proteins of unknown function from tailed bacteriophages and Firmicutes, including putative head-tail joining bacteriophage proteins.

[]

0

[ "PFAM" ]

[ "PF06341" ]

[ "DUF1056" ]

[ 241 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Gossypium raimondii", "Halobaculum halobium" ]

[ 158, 81, 1, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1056

DUF1056

3

IPR009407

9,407

Viral polyprotein, parechovirus P3B

VPP_parechovir_P3B

Domain

252

false

The viral polyprotein of parechoviruses contains: coat protein VP0 (P1AB); coat protein VP3 (P1C); coat protein VP1 (P1D); picornain 2A ( , core protein P2A); core protein P2B; core protein P2C; core protein P3A; genome-linked protein VPg (P3B); picornain 3C ( , MEROPS peptidase subfamily 3CF: parechovirus picornain 3C...

[]

0

[ "PFAM" ]

[ "PF06344" ]

[ "Parecho_VpG" ]

[ 252 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.48", "3.4.22.28", "3.6.1.15", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:2.7.7.48", "EC:3.4.22.28", "EC:3.6.1.15", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

8

[]

0

[ "PUB00033908" ]

[ "9820139" ]

[ "Molecular analysis of human parechovirus type 2 (formerly echovirus 23)." ]

[ 1998 ]

1

[]

0

null

[ "Parechovirus" ]

[ 252 ]

1

[]

0

true

Domain

Viral polyprotein, parechovirus P3B

VPP_parechovir_P3B

5

IPR009410

9,410

Allene oxide cyclase

Allene_ox_cyc

Family

1,394

false

This family consists of several plant specific allene oxide cyclase proteins ( ). The allene oxide cyclase (AOC)-catalysed step in jasmonate (JA) biosynthesis is important in the wound response of tomato [ ].

[ "GO:0016853" ]

[ "isomerase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06351", "PTHR31843" ]

[ "Allene_ox_cyc", "" ]

[ 1390, 1365 ]

2

[ "EC", "METACYC" ]

[ "5.3.99.6", "PWY-735" ]

[ "EC:5.3.99.6", "METACYC:PWY-735" ]

2

[ "1z8k", "1zvc", "2brj", "2dio", "2gin", "2q4i", "4cq6", "4cq7", "4h69", "4h6a", "4h6b", "4h6c" ]

12

[ "PUB00012334" ]

[ "12581315" ]

[ "Allene oxide cyclase dependence of the wound response and vascular bundle-specific generation of jasmonates in tomato - amplification in wound signalling." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Viridiplantae" ]

[ 25, 1369 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 1, 7 ]

3

true

Family

Allene oxide cyclase

Allene_ox_cyc

6

IPR009412

9,412

Protein of unknown function DUF1062

DUF1062

Family

2,078

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06353", "PIRSF021719" ]

[ "DUF1062", "DUF1062" ]

[ 2078, 871 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 2074, 4 ]

2

[]

0

true

Family

Protein of unknown function DUF1062

DUF1062

7

IPR009413

9,413

Hemolysin, aegerolysin type

Aegerolysin-typ

Family

888

false

This family consists of several bacterial and eukaryotic Aegerolysin-like proteins. Aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies, and these haemolysins may play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during...

[ "GO:0019836" ]

[ "symbiont-mediated hemolysis of host erythrocyte" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF06355", "PIRSF007951" ]

[ "Aegerolysin", "" ]

[ 888, 340 ]

2

[]

0

[ "4jox", "4oeb", "4v2t", "4v3a", "4v3m", "4v3n", "5v3s", "6myi", "6myj", "6myk", "6zc1", "6zc2", "9do6", "9do7", "9do8", "9do9", "9doa", "9dob" ]

18

[ "PUB00012335", "PUB00044762" ]

[ "12020804", "15912956" ]

[ "Pleurotus and Agrocybe hemolysins, new proteins hypothetically involved in fungal fruiting.", "Temporal and spatial expression of ostreolysin during development of the oyster mushroom (Pleurotus ostreatus)." ]

[ 2002, 2005 ]

2

[]

0

null

[ "Ascovirus", "Bacteria", "Eukaryota" ]

[ 2, 132, 754 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Hemolysin, aegerolysin type

Aegerolysin-typ

7

IPR009414

9,414

Protein of unknown function DUF1064

DUF1064

Family

1,766

false

This entry includes Bacteriophage 92, Orf34. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several phage and bacterial proteins whose functions have not been experimentally determined. Computational analysis involving sequence, predict...

[]

0

[ "PFAM" ]

[ "PF06356" ]

[ "DUF1064" ]

[ 1766 ]

1

[]

0

[]

0

[ "PUB00020736" ]

[ "15972856" ]

[ "Identification of novel restriction endonuclease-like fold families among hypothetical proteins." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Methanospirillum stamsii", "Opisthokonta", "Viruses", "metagenomes" ]

[ 1402, 1, 2, 282, 79 ]

5

[]

0

true

Family

Protein of unknown function DUF1064

DUF1064

9

IPR009415

9,415

Omega-atracotoxin

Omega-atracotox

Family

91

false

This family consists of several Hadronyche versuta (Blue mountains funnel-web spider) specific omega-atracotoxin proteins. Omega-Atracotoxin-Hv1a is an insect-specific neurotoxin whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatial...

[ "GO:0019855", "GO:0006952", "GO:0005576" ]

[ "calcium channel inhibitor activity", "defense response", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06357" ]

[ "Omega-toxin" ]

[ 91 ]

1

[ "PROSITEDOC" ]

[ "PDOC60016" ]

[ "PROSITEDOC:PDOC60016" ]

1

[ "1axh", "1hvw", "2h1z", "9kfq" ]

4

[ "PUB00012336" ]

[ "11313356" ]

[ "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a." ]

[ 2001 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 91 ]

1

[]

0

true

Family

Omega-atracotoxin

Omega-atracotox

2

IPR009417

9,417

Rice tungro bacilliform virus P12

RTBV_P12

Family

32

false

This family consists of several Rice tungro bacilliform virus P12 proteins. The function of this family is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF06361" ]

[ "RTBV_P12" ]

[ 32 ]

1

[]

0

[]

0

[ "PUB00012338" ]

[ "2041739" ]

[ "An analysis of the sequence of an infectious clone of rice tungro bacilliform virus, a plant pararetrovirus." ]

[ 1991 ]

1

[]

0

null

[ "Tungrovirus" ]

[ 32 ]

1

[]

0

true

Family

Rice tungro bacilliform virus P12

RTBV_P12

7

IPR009419

9,419

Viral polyprotein, parechovirus P3A

VPP_parechovir_P3A

Domain

288

false

The viral polyprotein of parechoviruses contains: coat protein VP0 (P1AB); coat protein VP3 (P1C); coat protein VP1 (P1D); picornain 2A ( , core protein P2A); core protein P2B; core protein P2C; core protein P3A; genome-linked protein VPg (P3B); picornain 3C ( , MEROPS peptidase subfamily 3CF: parechovirus picornain 3C...

[ "GO:0044423" ]

[ "virion component" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF06363" ]

[ "Picorna_P3A" ]

[ 288 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.48", "3.4.22.28", "3.6.1.15", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:2.7.7.48", "EC:3.4.22.28", "EC:3.6.1.15", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

8

[]

0

[ "PUB00012339", "PUB00033908" ]

[ "3018280", "9820139" ]

[ "Detection of a genome-linked protein (VPg) of hepatitis A virus and its comparison with other picornaviral VPgs.", "Molecular analysis of human parechovirus type 2 (formerly echovirus 23)." ]

[ 1986, 1998 ]

2

[]

0

null

[ "Micrurus corallinus", "Picornavirales" ]

[ 1, 287 ]

2

[]

0

true

Domain

Viral polyprotein, parechovirus P3A

VPP_parechovir_P3A

5

IPR009420

9,420

Flagellar protein FlhE

FlhE

Family

1,512

false

This family consists of several Enterobacterial FlhE flagellar proteins. The absence of FlhE results in a proton leak through the flagellar system, inappropriate secretion patterns, and cell death. FlhE is a member of the flhBAE operon. FlhA and FlhB are established components of the flagellar type III secretion system...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047946", "PF06366" ]

[ "FlgBrkeFlhE", "FlhE" ]

[ 780, 1512 ]

2

[]

0

[ "4qxl" ]

1

[ "PUB00076720", "PUB00163153" ]

[ "25545591", "22435757" ]

[ "Structure of Salmonella FlhE, conserved member of a flagellar type III secretion operon.", "Loss of FlhE in the flagellar Type III secretion system allows proton influx into Salmonella and Escherichia coli." ]

[ 2015, 2012 ]

2

[]

0

null

[ "Bacteria", "Trichomalopsis sarcophagae", "ecological metagenomes" ]

[ 1507, 1, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar protein FlhE

FlhE

1

IPR009422

9,422

Gem-associated protein 6

Gemin6

Family

1,377

false

This family consists of several animal Gemin6 proteins. The exact function of Gemin6 is unknown but it has been found to form part of the Survival of motor neuron complex. The SMN complex plays a key role in the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and other ribonucleoprotein particles [...

[ "GO:0000245", "GO:0005634" ]

[ "spliceosomal complex assembly", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR14710" ]

[ "" ]

[ 1377 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-191859", "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]

[ "REACTOME:R-BTA-191859", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]

4

[ "1y96", "7bbl" ]

2

[ "PUB00012343" ]

[ "11748230" ]

[ "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1377 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 4 ]

5

true

Family

Gem-associated protein 6

Gemin6

1

IPR009423

9,423

NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2

NDUC2

Family

1,448

false

This family consists of several NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUC2 or NDUFC2, also known as NADH-ubiquinone oxidoreductase subunit b14.5b) proteins. It is an accessory protein, not involved in catalysis [ , ].

[ "GO:0006120", "GO:0005743" ]

[ "mitochondrial electron transport, NADH to ubiquinone", "mitochondrial inner membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF06374", "PIRSF017834" ]

[ "NDUF_C2", "NADH-UbQ_OxRdtase_b14.5b" ]

[ 1448, 868 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6798695", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6798695", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6798695", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-6799198" ]

9

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf"...

209

[ "PUB00005074", "PUB00043561", "PUB00045437", "PUB00086570", "PUB00097152" ]

[ "1470679", "10940377", "18394423", "27626371", "31485716" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).", "Accessory subunits are in...

[ 1992, 2000, 2008, 2016, 2020 ]

5

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 1447, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 8, 3, 3 ]

6

true

Family

NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2

NDUC2

7

IPR009424

9,424

Arabinogalactan protein 16/20/22/41

AGP16/20/22/41

Family

2,163

false

This entry represents a group of arabinogalactan proteins (AGPs) from plants, and includes AGP16, AGP20, AGP22 and AGP41 [ ]. These proteoglycans have been implicated in various processes associated with plant growth and development, including embryogenesis and cell proliferation

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06376", "PTHR33374" ]

[ "AGP", "" ]

[ 2159, 2021 ]

2

[]

0

[]

0

[ "PUB00053881" ]

[ "11006345" ]

[ "The classical arabinogalactan protein gene family of arabidopsis." ]

[ 2000 ]

1

[]

0

null

[ "Embryophyta" ]

[ 2163 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 23, 31 ]

3

true

Family

Arabinogalactan protein 16/20/22/41

AGP16/20/22/41

2

IPR009425

9,425

SSAP, RNA binding domain

DSRM_SSAP

Domain

629

false

This entry describes the RNA binding domain from the Sak Single-Strand Annealing Protein (SSAP) from Staphylococcal Bacteriophage 80alpha, which is part of the Rad52-like superfamily. The Sak protein from phage 80alpha shares similarities with other SSAPs, such as Red-beta from phage lambda and RAD52 from eukaryotes. S...

[]

0

[ "PFAM" ]

[ "PF06378" ]

[ "SSAP_Sak" ]

[ 629 ]

1

[]

0

[ "8pq8", "8qe9" ]

2

[ "PUB00056679", "PUB00056680" ]

[ "21276096", "15150253" ]

[ "Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism.", "Lactococcal phage genes involved in sensitivity to AbiK and their relation to single-strand annealing proteins." ]

[ 2011, 2004 ]

2

[]

0

null

[ "Bacteria", "Methanolapillus millepedarum", "Viruses", "unclassified sequences" ]

[ 368, 1, 251, 9 ]

4

[]

0

true

Domain

SSAP, RNA binding domain

DSRM_SSAP

3

IPR009426

9,426

Barley yellow dwarf virus (BYDV), Gp6

BYDV_Gp6

Family

80

false

This family consists of several Barley yellow dwarf virus proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06380" ]

[ "DUF1072" ]

[ 80 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Luteovirus" ]

[ 80 ]

1

[]

0

true

Family

Barley yellow dwarf virus (BYDV), Gp6

BYDV_Gp6

3

IPR009427

9,427

Uncharacterised conserved protein UCP020357

UCP020357

Family

85

false

This entry represents a protein family of unknown function found in Borrelia species.

[]

0

[ "PIRSF" ]

[ "PIRSF020357" ]

[ "DUF1073" ]

[ 85 ]

1

[]

0

[ "8pho", "8php", "8phu", "8qo0", "8qo1" ]

5

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 85 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP020357

UCP020357

8

IPR009428

9,428

Beta-catenin-interacting ICAT domain

ICAT_dom

Domain

2,149

false

This domain is characteristic of eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various can...

[ "GO:0008013" ]

[ "beta-catenin binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06384" ]

[ "ICAT" ]

[ 2149 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3769402", "R-HSA-3769402", "R-MMU-3769402" ]

[ "REACTOME:R-BTA-3769402", "REACTOME:R-HSA-3769402", "REACTOME:R-MMU-3769402" ]

3

[ "1luj", "1m1e", "1t08" ]

3

[ "PUB00012347", "PUB00069800", "PUB00069801" ]

[ "12408824", "11712074", "15932753" ]

[ "The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.", "Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain.", "LZIC regulates neuronal survival during zebrafish development." ]

[ 2002, 2001, 2005 ]

3

[]

0

null

[ "Eukaryota", "Priestia veravalensis" ]

[ 2148, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 3, 2, 4 ]

5

true

Domain

Beta-catenin-interacting ICAT domain

ICAT_dom

2

IPR009429

9,429

Baculovirus LEF-11

Baculo_LEF-11

Family

146

false

This family consists of several Baculovirus LEF-11 proteins. The exact function of this family is unknown although it has been shown that LEF-11 is required for viral DNA replication during the infection cycle [ ] and plays a role in late/very late gene activation.

[ "GO:0006355", "GO:0019058" ]

[ "regulation of DNA-templated transcription", "viral life cycle" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF06385" ]

[ "Baculo_LEF-11" ]

[ 146 ]

1

[]

0

[]

0

[ "PUB00012348" ]

[ "11861844" ]

[ "Analysis of an Autographa californica nucleopolyhedrovirus lef-11 knockout: LEF-11 is essential for viral DNA replication." ]

[ 2002 ]

1

[]

0

null

[ "Baculoviridae", "Marine Group I thaumarchaeote" ]

[ 144, 2 ]

2

[]

0

true

Family

Baculovirus LEF-11

Baculo_LEF-11

5

IPR009430

9,430

Gas vesicle protein L/F

GvpL/GvpF

Family

5,501

false

Gas vesicles provide cells with buoyancy, enabling them to remain at the water surface. These organelles are generally synthesised by halophilic archaea and cyanobacteria, as well as some other prokaryotes. A cluster of 12-14 gvp genes (gvpMLKJIHGFEDACNO) is responsible for gas vesicle synthesis in Halobacterium sp. [ ...

[ "GO:0031412", "GO:0031411" ]

[ "gas vesicle organization", "gas vesicle" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06386", "PTHR36852" ]

[ "GvpL_GvpF", "" ]

[ 5501, 5374 ]

2

[ "GP" ]

[ "GenProp0460" ]

[ "GP:GenProp0460" ]

1

[ "4qsg", "6l5d" ]

2

[ "PUB00014923" ]

[ "15126480" ]

[ "Complexity of gas vesicle biogenesis in Halobacterium sp. strain NRC-1: identification of five new proteins." ]

[ 2004 ]

1

[]

[ "IPR054796" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 321, 5168, 2, 10 ]

4

[]

0

true

Family

Gas vesicle protein L/F

GvpL/GvpF

4

IPR009431

9,431

Neuronal vesicle trafficking-associated protein

NSG

Family

2,418

false

This family includes the neuron-enriched endosomal proteins NSG1 (NEEP21), NSG2 (P19) and NSG3 (calcyon, Caly). They interact with distinct elements of the endosomal and synaptic scaffolding machinery [ ]. NSG1 and NSG2 may not be resident endosomal proteins, and are also known as neuronal vesicle trafficking-associate...

[ "GO:0032051", "GO:0048268", "GO:0016020" ]

[ "clathrin light chain binding", "clathrin coat assembly", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06387", "PIRSF002383", "PTHR28546" ]

[ "Calcyon", "Calcyon", "" ]

[ 2418, 1357, 2399 ]

3

[ "IUPHAR" ]

[ "214" ]

[ "IUPHAR:214" ]

1

[]

0

[ "PUB00012349", "PUB00012350", "PUB00019244", "PUB00064276", "PUB00064277", "PUB00064278", "PUB00064280", "PUB00088059", "PUB00088062", "PUB00088065" ]

[ "11929934", "11923911", "12622665", "17170272", "17885599", "17623072", "16595675", "25376768", "28299779", "28874679" ]

[ "D1/D5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons.", "A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.", "Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophre...

[ 2002, 2002, 2003, 2006, 2007, 2007, 2006, 2015, 2017, 2017 ]

10

[]

0

null

[ "Chordata" ]

[ 2418 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 12, 11, 9 ]

4

true

Family

Neuronal vesicle trafficking-associated protein

NSG

4

IPR009432

9,432

Protein of unknown function DUF1075

DUF1075

Family

2,478

false

This family consists of several eukaryotic proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06388", "PTHR13674" ]

[ "DUF1075", "" ]

[ 2470, 2390 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Metazoa" ]

[ 2478 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 11, 4, 9 ]

6

true

Family

Protein of unknown function DUF1075

DUF1075

5

IPR009433

9,433

Filovirus membrane-associated VP24

Filo_VP24

Family

343

false

This family consists of several membrane-associated protein VP24 sequences from a variety of Ebola viruses, as well as Lake Victoria marburgvirus. The VP24 protein of Ebola virus sp. is believed to be a secondary matrix protein and minor component of virions. VP24 possesses structural features commonly associated with ...

[ "GO:0005198", "GO:0016032", "GO:0016020" ]

[ "structural molecule activity", "viral process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF06389", "PIRSF011355" ]

[ "Filo_VP24", "VP24" ]

[ 343, 248 ]

2

[]

0

[ "3vne", "3vnf", "4d9o", "4m0q", "4or8", "4u2x", "6ehm", "8usn", "8ust", "8y9j" ]

10

[ "PUB00012357" ]

[ "12525613" ]

[ "Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding." ]

[ 2003 ]

1

[]

0

null

[ "Filoviridae" ]

[ 343 ]

1

[]

0

true

Family

Filovirus membrane-associated VP24

Filo_VP24

1

IPR009434

9,434

Neuroendocrine secretory protein 55

NESP55

Family

148

false

The imprinted GNAS cluster, located on chromosome 2 in mice and chromosome 20 in humans, contains transcripts that are maternally, paternally, and/or biallelically expressed. Neuroendocrine secretory protein 55 (NESP55) is encoded by an upstream exon of the GNAS1 gene, which is expressed exclusively from the maternal a...

[ "GO:0071107" ]

[ "response to parathyroid hormone" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06390" ]

[ "NESP55" ]

[ 148 ]

1

[]

0

[]

0

[ "PUB00012358", "PUB00074854", "PUB00074855", "PUB00074856" ]

[ "12438142", "9860993", "23839232", "22378814" ]

[ "Neuroendocrine secretory protein 55: a novel marker for the constitutive secretory pathway.", "Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins.", "Maternal inheritance of the Gnas cluster mutation Ex1A-T affects size, implicating NESP55 in gro...

[ 2002, 1998, 2013, 2012 ]

4

[]

0

null

[ "Eutheria" ]

[ 148 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3 ]

3

true

Family

Neuroendocrine secretory protein 55

NESP55

8

IPR009436

9,436

Type-1 angiotensin II receptor-associated protein

AGTRAP

Family

1,482

false

AGTRAP (type-1 angiotensin II receptor-associated protein) appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation [ ]. It plays an important role in cardiac hypertrophy [ ].

[ "GO:0038166" ]

[ "angiotensin-activated signaling pathway" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER", "SMART" ]

[ "PF06396", "PTHR16521", "SM00805" ]

[ "AGTRAP", "", "AGTRAP" ]

[ 1482, 1394, 1325 ]

3

[ "IUPHAR", "REACTOME" ]

[ "34", "R-HSA-6802952" ]

[ "IUPHAR:34", "REACTOME:R-HSA-6802952" ]

2

[]

0

[ "PUB00019116", "PUB00078888" ]

[ "10358057", "15757644" ]

[ "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.", "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy." ]

[ 1999, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1482 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 4, 1, 3 ]

5

true

Family

Type-1 angiotensin II receptor-associated protein

AGTRAP

3

IPR009437

9,437

Lamprin

Family

48

false

This family consists of several lamprin proteins from Petromyzon marinus (sea lamprey). Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage. Although not generally homologous to any other protein, soluble la...

[ "GO:0005198", "GO:0031012" ]

[ "structural molecule activity", "extracellular matrix" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF06403", "PIRSF002264" ]

[ "Lamprin", "Lamprin" ]

[ 48, 13 ]

2

[]

0

[]

0

[ "PUB00012368" ]

[ "7678258" ]

[ "Characterization of lamprin, an unusual matrix protein from lamprey cartilage. Implications for evolution, structure, and assembly of elastin and other fibrillar proteins." ]

[ 1993 ]

1

[]

0

null

[ "Actinorhabdospora filicis", "Opisthokonta" ]

[ 1, 47 ]

2

[]

0

true

Family

Lamprin

4

IPR009439

9,439

Red chlorophyll catabolite reductase

RCC_reductase

Family

1,015

false

This family consists of several red chlorophyll catabolite reductase (RCC reductase) proteins. Red chlorophyll catabolite (RCC) reductase (RCCR) and pheophorbide (Pheide) a oxygenase (PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite ...

[ "GO:0051743" ]

[ "red chlorophyll catabolite reductase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06405", "PTHR34685" ]

[ "RCC_reductase", "" ]

[ 1014, 982 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "1.3.7.12", "PWY-5098", "PWY-6927" ]

[ "EC:1.3.7.12", "METACYC:PWY-5098", "METACYC:PWY-6927" ]

3

[ "2zxk", "2zxl", "3aga", "3agb", "3agc" ]

5

[ "PUB00012370", "PUB00093996" ]

[ "10743659", "21807436" ]

[ "Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.", "Knockdown of OsPAO and OsRCCR1 cause different plant death phenotypes in rice." ]

[ 2000, 2011 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 199, 806, 10 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 11, 2 ]

3

true

Family

Red chlorophyll catabolite reductase

RCC_reductase

6

IPR009440

9,440

Plasmid segregation protein ParM/StbA, N-terminal

ParM/StbA_N

Domain

1,543

false

This entry represents the N-terminal domain of bacterial plasmid segregation protein ParM, also known as StbA [ , ]. ParM is involved in the control of plasmid partition and required for the accurate segregation of the plasmid, which forms filaments to drive partition.

[]

0

[ "PFAM" ]

[ "PF06406" ]

[ "StbA_N" ]

[ 1543 ]

1

[]

0

[ "1mwk", "1mwm", "2qu4", "2zgy", "2zgz", "2zhc", "3iku", "3iky", "4a61", "4a62", "4a6j", "5aey", "5ai7" ]

13

[ "PUB00012371", "PUB00092376" ]

[ "1706707", "20106979" ]

[ "Transcription of the stability operon of IncFII plasmid NR1.", "Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation." ]

[ 1991, 2010 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Ecdysozoa", "metagenomes" ]

[ 1534, 3, 3, 3 ]

4

[]

0

true

Domain

Plasmid segregation protein ParM/StbA, N-terminal

ParM/StbA_N

1

IPR009441

9,441

P40 nucleoprotein, Borna disease virus

P40_nucleoprot_BD-vir

Family

549

false

This entry represents P40 nucleoproteins from several Borna disease virus (BDV) strains. BDV is an RNA virus that is a member of the Mononegavirales family, which includes such members as Measles virus and Ebola virus sp.. BDV causes an infection of the central nervous system in a wide range of vertebrates, which can p...

[]

0

[ "PFAM" ]

[ "PF06407" ]

[ "BDV_P40" ]

[ 549 ]

1

[]

0

[ "1n93", "1pp1" ]

2

[ "PUB00012372", "PUB00029014" ]

[ "9882386", "14527390" ]

[ "Borna disease virus nucleoprotein (p40) is a major target for CD8(+)-T-cell-mediated immune response.", "Crystal structure of the borna disease virus nucleoprotein." ]

[ 1999, 2003 ]

2

[]

0

null

[ "Bilateria", "Mononegavirales" ]

[ 94, 455 ]

2

[ "Homo sapiens" ]

[ 2 ]

1

true

Family

P40 nucleoprotein, Borna disease virus

P40_nucleoprot_BD-vir

6

IPR009443

9,443

Nuclear pore complex interacting protein

NPIP

Family

349

false

This family consists of a series of primate-specific nuclear pore complex-interacting protein (NPIP) sequences. NPIP are not considered one of the core structural nucleoporins that form the main scaffold of the nuclear pore complex (NPC), but it is classified as a nucleoporin-associated protein. This family is well con...

[]

0

[ "PANTHER" ]

[ "PTHR15438" ]

[ "" ]

[ 349 ]

1

[ "REACTOME" ]

[ "R-HSA-9692916" ]

[ "REACTOME:R-HSA-9692916" ]

1

[]

0

[ "PUB00012374", "PUB00160785" ]

[ "11586358", "25691464" ]

[ "Positive selection of a gene family during the emergence of humans and African apes.", "Nuclear pore proteins and the control of genome functions." ]

[ 2001, 2015 ]

2

[]

0

null

[ "Enterobacter hormaechei", "Eukaryota" ]

[ 1, 348 ]

2

[ "Homo sapiens" ]

[ 145 ]

1

true

Family

Nuclear pore complex interacting protein

NPIP

3

IPR009444

9,444

Conjugal transfer, TraD, alpha-type

Conjugal_tfr_TraD_a-type

Family

3,172

false

This family consists of a group of TraD conjugal transfer proteins found primarily, though not exclusively, in the alphaproteobacteria [ ].

[]

0

[ "PFAM" ]

[ "PF06412" ]

[ "TraD" ]

[ 3172 ]

1

[ "GP" ]

[ "GenProp0490" ]

[ "GP:GenProp0490" ]

1

[]

0

[ "PUB00012375" ]

[ "8763953" ]

[ "The tra region of the nopaline-type Ti plasmid is a chimera with elements related to the transfer systems of RSF1010, RP4, and F." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3150, 7, 15 ]

3

[]

0

true

Family

Conjugal transfer, TraD, alpha-type

Conjugal_tfr_TraD_a-type

1

IPR009445

9,445

ER membrane protein complex subunit 4

TMEM85/Emc4

Family

4,469

false

This entry includes ER membrane protein complex subunit 4 (EMC4, also known as TMEM85 in mammals) from animals and its orthologue Emc4 from budding yeasts. They inhibit hydrogen peroxide mediated cell death in yeast [ ]. Emc4 is part of the ER membrane complex (EMC) that enables the energy-independent insertion into en...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06417", "PIRSF017207", "PTHR19315" ]

[ "EMC4", "UCP017207_TM-p85", "" ]

[ 4465, 2720, 4326 ]

3

[]

0

[ "6wb9", "6z3w", "7ado", "7adp", "7kra", "7ktx", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

11

[ "PUB00067575", "PUB00086405", "PUB00096681", "PUB00096682" ]

[ "23431131", "18586032", "32459176", "32439656" ]

[ "Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex.", "Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.", "The architecture of EMC reveals a path for membrane protein insertion...

[ 2013, 2008, 2020, 2020 ]

4

[]

0

null

[ "Eukaryota", "Shewanella electrica" ]

[ 4468, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 1, 1, 6, 1, 1, 3, 3, 1, 1, 4 ]

12

true

Family

ER membrane protein complex subunit 4

TMEM85/Emc4

9

IPR009446

9,446

Mitochondrial genome maintenance protein Mgm101

Mgm101

Family

1,763

false

The Mgm101 is a Rad52-type single-stranded annealing protein (SSAP) required for mitochondrial DNA (mtDNA) repair and maintenance. Its C-terminal tail is required for single-stranded DNA binding [ ]. It may also play roles in the replication of the mitochondrial genome and the maintenance of its telomeres [ ].

[ "GO:0003697", "GO:0006281", "GO:0000262" ]

[ "single-stranded DNA binding", "DNA repair", "mitochondrial chromosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06420", "PTHR31404" ]

[ "Mgm101p", "" ]

[ 1763, 1750 ]

2

[]

0

[ "9yi6", "9yi7", "9yi8", "9yi9", "9yia" ]

5

[ "PUB00084984", "PUB00084985" ]

[ "23536705", "26743001" ]

[ "A short carboxyl-terminal tail is required for single-stranded DNA binding, higher-order structural organization, and stability of the mitochondrial single-stranded annealing protein Mgm101.", "The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome." ]

[ 2013, 2016 ]

2

[]

0

null

[ "Candidatus Brocadiaceae", "Eukaryota", "metagenomes" ]

[ 3, 1755, 5 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial genome maintenance protein Mgm101

Mgm101

1

IPR009447

9,447

Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1

PIGW/GWT1

Family

4,949

false

Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis [ ]. Mutations in PIGW are associated with...

[ "GO:0016746", "GO:0006506", "GO:0016020" ]

[ "acyltransferase activity", "GPI anchor biosynthetic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06423", "PIRSF017321", "PTHR20661" ]

[ "GWT1", "GWT1", "" ]

[ 4945, 3179, 4806 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-162710", "R-HSA-162710", "R-MMU-162710", "R-RNO-162710", "R-SCE-162710", "R-SPO-162710" ]

[ "REACTOME:R-DDI-162710", "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710", "REACTOME:R-RNO-162710", "REACTOME:R-SCE-162710", "REACTOME:R-SPO-162710" ]

6

[ "8xij", "8xik" ]

2

[ "PUB00013427", "PUB00089749" ]

[ "12714589", "24367057" ]

[ "GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.", "Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome." ]

[ 2003, 2014 ]

2

[]

0

null

[ "Candidatus Lokiarchaeum ossiferum", "Eukaryota" ]

[ 1, 4948 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 1, 2, 2, 2, 2, 4, 3, 1, 1, 28 ]

12

true

Family

Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1

PIGW/GWT1

5

IPR009448

9,448

UDP-glucose:Glycoprotein Glucosyltransferase

UDP-g_GGtrans

Family

8,301

false

The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. These proteins selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substra...

[ "GO:0003980", "GO:0009101" ]

[ "UDP-glucose:glycoprotein glucosyltransferase activity", "glycoprotein biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06427", "PTHR11226" ]

[ "UDP-g_GGTase", "" ]

[ 6156, 8297 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

201

[ "5h18", "5mu1", "5mzo", "5n2j", "5nv4", "5y7f", "5y7o", "6fsn", "6trf", "6trt", "6ts2", "6ts8", "7zhb", "7zkc", "7zle", "7zll", "7zlu", "7zxw" ]

18

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 8298 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 8, 1, 11, 14, 1, 5, 10, 1, 1, 19 ]

12

true

Family

UDP-glucose:Glycoprotein Glucosyltransferase

UDP-g_GGtrans

9

IPR009449

9,449

GDP/GTP exchange factor Sec2, N-terminal

Sec2_N

Domain

6,512

false

In Saccharomyces cerevisiae, Sec2 is a GDP/GTP exchange factor for Rab GTPase Sec4, which is required for vesicular transport at the post-Golgi stage of yeast secretion [ ]. It catalyses the dissociation of GDP from Sec4, also potently promoting binding of GTP. Activation of Sec4 by Sec2 is needed for the directed tran...

[]

0

[ "PFAM" ]

[ "PF06428" ]

[ "Sec2p" ]

[ 6512 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8876198", "R-HSA-5620912", "R-HSA-5620916", "R-HSA-5620922", "R-HSA-8876198", "R-MMU-8876198", "R-RNO-5620912", "R-RNO-5620916", "R-RNO-5620922", "R-RNO-8876198", "R-SCE-5620912", "R-SCE-8876198", "R-SPO-5620912", "R-SPO-8876198" ]

[ "REACTOME:R-BTA-8876198", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-5620916", "REACTOME:R-HSA-5620922", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-8876198", "REACTOME:R-RNO-5620912", "REACTOME:R-RNO-5620916", "REACTOME:R-RNO-5620922", "REACTOME:R-RNO-8876198", "REACTOME:R-SCE-5620912", "REACTOM...

14

[ "2e7s", "2eqb", "2ocy", "4lhx", "4lhy", "4lhz", "4li0", "4zdw", "6f6p" ]

9

[ "PUB00012383", "PUB00053588", "PUB00053589" ]

[ "9199166", "10747090", "12045183" ]

[ "Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles.", "The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles.", "Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade i...

[ 1997, 2000, 2002 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6512 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 24, 5, 7, 2, 12, 1, 2 ]

7

true

Domain

GDP/GTP exchange factor Sec2, N-terminal

Sec2_N

1

IPR009450

9,450

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Plno_GlcNAc_GPI2

Family

4,192

false

This entry represents the subunit C of the phosphatidylinositol N-acetylglucosaminyltransferase (PIG-C) and its yeast homologue, Gpi2. It catalyses the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This step involves products of three or four g...

[ "GO:0006506", "GO:0016020" ]

[ "GPI anchor biosynthetic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06432", "PIRSF016104", "PTHR12982" ]

[ "GPI2", "GPI2", "" ]

[ 4192, 2412, 4080 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-162710", "R-HSA-162710", "R-MMU-162710", "R-RNO-162710" ]

[ "REACTOME:R-BTA-162710", "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710", "REACTOME:R-RNO-162710" ]

4

[]

0

[ "PUB00068043" ]

[ "8806613" ]

[ "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2." ]

[ 1996 ]

1

[]

0

null

[ "Clostridium tertium", "Eukaryota" ]

[ 1, 4191 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 3, 1, 4, 1, 2, 3, 1, 1, 3 ]

12

true

Family

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Plno_GlcNAc_GPI2

9

IPR009451

9,451

Amine dehydrogenase heavy chain

Metamine_DH_Hvc

Family

784

false

This entry represents a group of bacterial amine dehydrogenase heavy chains. They include methylamine [ ] and arylamine dehydrogenase heavy chains [ ], which form heterotetramers with their respective light chains, and catalyse the oxidative deamination of amines to their corresponding aldehydes.

[ "GO:0030058", "GO:0042597" ]

[ "aliphatic amine dehydrogenase activity", "periplasmic space" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06433" ]

[ "Me-amine-dh_H" ]

[ 784 ]

1

[ "EC", "METACYC" ]

[ "1.4.9.1", "PWY-6967" ]

[ "EC:1.4.9.1", "METACYC:PWY-6967" ]

2

[ "1mae", "1maf", "1mda", "1mg2", "1mg3", "2agl", "2agw", "2agx", "2agy", "2agz", "2ah0", "2ah1", "2bbk", "2gc4", "2gc7", "2h3x", "2h47", "2hj4", "2hjb", "2hkm", "2hkr", "2hxc", "2i0r", "2i0s", "2i0t", "2iaa", "2iup", "2iuq", "2iur", "2iuv", "2j55", "2j56"...

69

[ "PUB00012384", "PUB00077064" ]

[ "9514722", "11495996" ]

[ "Refined crystal structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 A resolution.", "Cloning, sequencing and mutagenesis of the genes for aromatic amine dehydrogenase from Alcaligenes faecalis and evolution of amine dehydrogenases." ]

[ 1998, 2001 ]

2

[]

[ "IPR013476" ]

0

1

0

[ "Bacteria", "Steinernema glaseri", "unclassified sequences" ]

[ 769, 1, 14 ]

3

[]

0

true

Family

Amine dehydrogenase heavy chain

Metamine_DH_Hvc

4

IPR009452

9,452

Pneumovirus matrix 2-1

Pneumovirus_M2-1

Family

508

false

This family includes several Pneumovirus matrix glycoprotein M2-1 sequences. Family members function as transcription processivity factors that are essential for virus replication [ , ].

[ "GO:0005198", "GO:0046782", "GO:0044423" ]

[ "structural molecule activity", "regulation of viral transcription", "virion component" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF06436", "PIRSF003913" ]

[ "Pneumovirus_M2", "Matrix_glycop-M2_paramyxo" ]

[ 508, 452 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9820960", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9828721", "R-HSA-9828806", "R-HSA-9833110", "R-HSA-9834752" ]

[ "REACTOME:R-HSA-9820960", "REACTOME:R-HSA-9820962", "REACTOME:R-HSA-9828642", "REACTOME:R-HSA-9828721", "REACTOME:R-HSA-9828806", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9834752" ]

7

[ "2l9j", "4c3b", "4c3d", "4c3e", "4cs7", "4cs8", "4cs9", "4csa", "5nkx", "5noh", "6g0y", "6pzq" ]

12

[ "PUB00012386", "PUB00095618" ]

[ "12692207", "15890897" ]

[ "Identification of amino acids that are critical to the processivity function of respiratory syncytial virus M2-1 protein.", "Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity." ]

[ 2003, 2005 ]

2

[]

0

null

[ "Pneumoviridae" ]

[ 508 ]

1

[]

0

true

Family

Pneumovirus matrix 2-1

Pneumovirus_M2-1

1

IPR009453

9,453

IMP-specific 5-nucleotidase

ISN1

Family

1,682

false

The Saccharomyces cerevisiae ISN1 (YOR155c) gene encodes an IMP-specific 5'-nucleotidase, which catalyses degradation of IMP to inosine as part of the purine salvage pathway.

[ "GO:0000287", "GO:0008253", "GO:0006190", "GO:0009117" ]

[ "magnesium ion binding", "5'-nucleotidase activity", "inosine salvage", "nucleotide metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06437", "PIRSF028836", "PTHR28213" ]

[ "ISN1", "ISN1", "" ]

[ 1681, 1127, 1650 ]

3

[ "EC" ]

[ "3.1.3.99" ]

[ "EC:3.1.3.99" ]

1

[ "6rmd", "6rme", "6rmo", "6rmw", "6rn1", "6rnh", "8j6h", "8jb3" ]

8

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1682 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

IMP-specific 5-nucleotidase

ISN1

6

IPR009454

9,454

Lipid transport, open beta-sheet

Lipid_transpt_open_b-sht

Domain

2,112

false

This entry represents a conserved open β-sheet domain found in several lipid transport proteins, including vitellogenin and apolipoprotein B-100 [ ]. Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinog...

[ "GO:0005319", "GO:0006869" ]

[ "lipid transporter activity", "lipid transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06448" ]

[ "DUF1081" ]

[ 2112 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-202733", "R-HSA-3000471", "R-HSA-3000480", "R-HSA-3000484", "R-HSA-3000497", "R-HSA-381426", "R-HSA-432142", "R-HSA-5686938", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-8866423", "R-HSA-8957275", "R-HSA-8963888", "R-HSA-8963901", "R-HSA-8964026", "R-HSA-8964038", "R-HSA-8964041"...

[ "REACTOME:R-HSA-202733", "REACTOME:R-HSA-3000471", "REACTOME:R-HSA-3000480", "REACTOME:R-HSA-3000484", "REACTOME:R-HSA-3000497", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-432142", "REACTOME:R-HSA-5686938", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-HSA-8866423", "REACTOME:R...

56

[ "9bd1", "9bd8", "9bde", "9bdt", "9coo", "9e9r", "9ea7", "9eag" ]

8

[ "PUB00005307", "PUB00007158", "PUB00035546", "PUB00035551" ]

[ "9687371", "12135361", "17314313", "16238675" ]

[ "The structural basis of lipid interactions in lipovitellin, a soluble lipoprotein.", "Lipid-protein interactions in lipovitellin.", "Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins.", "Apolipoprotein B: a clinically important apolipoprotein which ...

[ 1998, 2002, 2007, 2005 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 2112 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 5, 2, 4 ]

5

true

Domain

Lipid transport, open beta-sheet

Lipid_transpt_open_b-sht

3

IPR009455

9,455

ATP synthase YMF19, uncharacterised, C-terminal

YMF19

Domain

1,158

false

This domain represents the C-terminal region of YMF19 of the F0 complex of mitochondrial F-ATPases from plants [ ]. This domain is found C-terminal to the plant mitochondrial ATPase subunit 8 domain .

[ "GO:0005739", "GO:0016020" ]

[ "mitochondrion", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06449" ]

[ "YMF19_C" ]

[ 1158 ]

1

[ "EC", "METACYC" ]

[ "7.1.2.2", "PWY-7980" ]

[ "EC:7.1.2.2", "METACYC:PWY-7980" ]

2

[]

0

[ "PUB00016657" ]

[ "12681508" ]

[ "The products of the mitochondrial orf25 and orfB genes are FO components in the plant F1FO ATP synthase." ]

[ 2003 ]

1

[]

0

null

[ "Spermatophyta" ]

[ 1158 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 2 ]

3

true

Domain

ATP synthase YMF19, uncharacterised, C-terminal

YMF19

2

IPR009456

9,456

Moricin family

Moricin_fam

Family

114

false

Moricin is a antibacterial peptide that is highly basic. The structure of moricin reveals that it is comprised of a long α-helix. The N terminus of the helix is amphipathic, and the C terminus of the helix is predominately hydrophobic. The amphipathic N-terminal segment of the α-helix is mainly responsible for the incr...

[ "GO:0042742", "GO:0005576" ]

[ "defense response to bacterium", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06451" ]

[ "Moricin" ]

[ 114 ]

1

[]

0

[ "1kv4", "1x22", "2jr8" ]

3

[ "PUB00012610" ]

[ "11997013" ]

[ "Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori." ]

[ 2002 ]

1

[]

0

null

[ "Ditrysia" ]

[ 114 ]

1

[]

0

true

Family

Moricin family

Moricin_fam

5

IPR009459

9,459

MucBP domain

MucBP_dom

Domain

5,545

false

The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins.

[]

0

[ "PFAM" ]

[ "PF06458" ]

[ "MucBP" ]

[ 5545 ]

1

[]

0

[ "2kt7", "2kvz", "7lsa", "7lsr", "7lst", "7lsu", "7yl4", "7yl5", "7yl6", "9qf8", "9qfa" ]

11

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "Opisthokonta", "Siphoviridae sp. ctzSN25", "metagenomes" ]

[ 5524, 3, 8, 1, 9 ]

5

[]

0

true

Domain

MucBP domain

MucBP_dom

5

IPR009460

9,460

Ryanodine Receptor TM 4-6

Ryanrecept_TM4-6

Domain

6,271

false

The release of Ca 2+ ions from intracellular stores is a key step in a wide variety of cellular functions. In striated muscle, the release of Ca 2+ from the sarcoplasmic reticulum (SR) leads to muscle contraction. Ca 2+ release occurs through large, high-conductance Ca 2+ release channels, also known as ryanodine recep...

[ "GO:0005219", "GO:0006874", "GO:0016020" ]

[ "ryanodine-sensitive calcium-release channel activity", "intracellular calcium ion homeostasis", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06459" ]

[ "RR_TM4-6" ]

[ 6271 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2672351", "R-HSA-5578775", "R-MMU-2672351", "R-MMU-5578775", "R-RNO-2672351", "R-RNO-5578775" ]

[ "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-5578775", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-5578775", "REACTOME:R-RNO-2672351", "REACTOME:R-RNO-5578775" ]

6

[ "3j8h", "5gky", "5gkz", "5gl0", "5gl1", "5go9", "5goa", "5j8v", "5l1d", "5t15", "5t9m", "5t9n", "5t9r", "5t9s", "5t9v", "5ta3", "5tal", "5tam", "5tan", "5tap", "5taq", "5tas", "5tat", "5tau", "5tav", "5taw", "5tax", "5tay", "5taz", "5tb0", "5tb1", "5tb2"...

177

[ "PUB00014960" ]

[ "15110152" ]

[ "Molecular regulation of cardiac ryanodine receptor ion channel." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota", "Pantoea vagans" ]

[ 6270, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 52, 8, 21, 8, 14 ]

6

true

Domain

Ryanodine Receptor TM 4-6

Ryanrecept_TM4-6

8

IPR009461

9,461

Non-structural protein NSP16, coronavirus-like

NSP16_CoV-like

Domain

5,204

false

This domain covers the NSP16 region of the coronavirus polyprotein. It was originally named NSP13 and later changed to NSP16 to distinguish it from the helicase region [ ]. NSP16 is a 7-methylguanine-triphosphate-adenosine (m7GpppA)-specific, SAM-dependent 2'-O-MTase that has selective RNA binding properties and is a c...

[]

0

[ "PFAM", "CDD" ]

[ "PF06460", "cd20762" ]

[ "CoV_Methyltr_2", "capping_2-OMTase_Nidovirales" ]

[ 5190, 61 ]

2

[ "EC", "EC", "EC", "EC", "EC", "EC", "EC", "EC", "EC", "EC", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "2.1.1.56", "2.1.1.57", "2.7.7.48", "2.7.7.50", "3.1.13.-", "3.4.19.12", "3.4.22.-", "3.6.4.12", "3.6.4.13", "4.6.1.-", "GenProp1009", "PWY-7375", "PWY-7379", "R-HSA-191859", "R-HSA-918233", "R-HSA-9679504", "R-HSA-9682706", "R-HSA-9682708", "R-HSA-9683439", "R-HSA-9684325", ...

[ "EC:2.1.1.56", "EC:2.1.1.57", "EC:2.7.7.48", "EC:2.7.7.50", "EC:3.1.13.-", "EC:3.4.19.12", "EC:3.4.22.-", "EC:3.6.4.12", "EC:3.6.4.13", "EC:4.6.1.-", "GP:GenProp1009", "METACYC:PWY-7375", "METACYC:PWY-7379", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-918233", "REACTOME:R-HSA-9679504", ...

29

[ "2xyq", "2xyr", "2xyv", "3r24", "5yn5", "5yn6", "5yn8", "5ynb", "5ynf", "5yni", "5ynj", "5ynm", "5ynn", "5yno", "5ynp", "5ynq", "6w4h", "6w61", "6w75", "6wjt", "6wkq", "6wks", "6wq3", "6wrz", "6wvn", "6xkm", "6yz1", "7bq7", "7c2i", "7c2j", "7jhe", "7jib"...

90

[ "PUB00012615", "PUB00094082", "PUB00099680", "PUB00099890" ]

[ "12809601", "18417574", "33794150", "32994211" ]

[ "mRNA cap-1 methyltransferase in the SARS genome.", "Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity.", "SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential.", "High-resolution structures of t...

[ 2003, 2008, 2021, 2020 ]

4

[ "IPR046438" ]

[]

1

0

1

[ "Nidovirales" ]

[ 5204 ]

1

[]

0

true

Domain

Non-structural protein NSP16, coronavirus-like

NSP16_CoV-like

5

IPR009462

9,462

CHD subfamily II, SANT-like domain

CHD_II_SANT-like

Domain

7,598

false

CHD proteins (name derived from the presence of a Chromodomain, SWI2/SNF2 ATPase/Helicase and a motif with sequence similarity to a DNA-binding domain) are ATP-dependent chromatin remodelers found in plant and animals. In eukaryotes, there are three subfamilies, I, II and III. This domain is found in members of subfami...

[ "GO:0003677", "GO:0006338" ]

[ "DNA binding", "chromatin remodeling" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF06461", "SM01146" ]

[ "CHDII_SANT-like", "DUF1086" ]

[ 7594, 7554 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "3.6.4.-", "PWY-7250", "R-CEL-4551638", "R-CEL-6804758", "R-CEL-9031628", "R-DME-3214815", "R-DME-6804758", "R-DME-8943724", "R-DME-9031628", "R-HSA-3214815", "R-HSA-427389", "R-HSA-4551638", "R-HSA-6804758", "R-HSA-73762", "R-HSA-8943724", "R-HSA-9031628", "R-HSA-9679191", "R-HSA-...

[ "EC:3.6.4.-", "METACYC:PWY-7250", "REACTOME:R-CEL-4551638", "REACTOME:R-CEL-6804758", "REACTOME:R-CEL-9031628", "REACTOME:R-DME-3214815", "REACTOME:R-DME-6804758", "REACTOME:R-DME-8943724", "REACTOME:R-DME-9031628", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427389", "REACTOME:R-HSA-4551638", ...

25

[ "6ryr", "6ryu", "8d4y" ]

3

[ "PUB00098174" ]

[ "23128324" ]

[ "PICKLE is a CHD subfamily II ATP-dependent chromatin remodeling factor." ]

[ 2013 ]

1

[]

0

null

[ "Eukaryota" ]

[ 7598 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 15, 2, 22, 5, 34, 13, 3, 23, 23 ]

9

true

Domain

CHD subfamily II, SANT-like domain

CHD_II_SANT-like

3

IPR009463

9,463

Domain of unknown function DUF1087

DUF1087

Domain

8,276

false

This domain is found in chromatin remodelling factors (CHDs) from subfamily II, including CHD3/4/5 from animals and PICKLE from Arabidopsis [ ]. The exact function is, as yet, unknown.

[]

0

[ "PFAM", "SMART" ]

[ "PF06465", "SM01147" ]

[ "DUF1087", "DUF1087" ]

[ 8218, 8217 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "3.6.4.-", "PWY-7250", "R-CEL-4551638", "R-CEL-6804758", "R-CEL-9031628", "R-DME-3214815", "R-DME-6804758", "R-DME-8943724", "R-DME-9031628", "R-HSA-3214815", "R-HSA-427389", "R-HSA-4551638", "R-HSA-6804758", "R-HSA-73762", "R-HSA-8943724", "R-HSA-9031628", "R-HSA-9679191", "R-HSA-...

[ "EC:3.6.4.-", "METACYC:PWY-7250", "REACTOME:R-CEL-4551638", "REACTOME:R-CEL-6804758", "REACTOME:R-CEL-9031628", "REACTOME:R-DME-3214815", "REACTOME:R-DME-6804758", "REACTOME:R-DME-8943724", "REACTOME:R-DME-9031628", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427389", "REACTOME:R-HSA-4551638", ...

25

[ "6ryr", "6ryu" ]

2

[ "PUB00098174" ]

[ "23128324" ]

[ "PICKLE is a CHD subfamily II ATP-dependent chromatin remodeling factor." ]

[ 2013 ]

1

[]

0

null

[ "Enterobacter cancerogenus", "Eukaryota" ]

[ 1, 8275 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 2, 22, 5, 32, 12, 3, 23, 49 ]

9

true

Domain

Domain of unknown function DUF1087

DUF1087

4

IPR009464

9,464

PCAF, N-terminal

PCAF_N

Domain

3,356

false

This region is spliced out of isoform 2. It is predicted to be of a mixed α/β fold - though predominantly helical.

[ "GO:0004402", "GO:0006355", "GO:0005634" ]

[ "histone acetyltransferase activity", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06466" ]

[ "PCAF_N" ]

[ 3356 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "2.3.1", "2.3.1.48", "R-DRE-2032785", "R-DRE-5689880", "R-DRE-5689901", "R-DRE-9018519", "R-DRE-9617629", "R-HSA-1912408", "R-HSA-2032785", "R-HSA-210744", "R-HSA-2122947", "R-HSA-2644606", "R-HSA-2894862", "R-HSA-3214847", "R-HSA-350054", "R-HSA-5250924", "R-HSA-5578768", "R-HSA-5...

[ "EC:2.3.1", "EC:2.3.1.48", "REACTOME:R-DRE-2032785", "REACTOME:R-DRE-5689880", "REACTOME:R-DRE-5689901", "REACTOME:R-DRE-9018519", "REACTOME:R-DRE-9617629", "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-2032785", "REACTOME:R-HSA-210744", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-2644606", "REACT...

40

[ "7by1" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3356 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 4, 8, 7 ]

6

true

Domain

PCAF, N-terminal

PCAF_N

4