LiteFold/InterPro · Datasets at Hugging Face

IPR009221

9,221

Corrinoid adenosyltransferase PduO

PduO

Family

904

false

ATP:cob(I)alamin (or ATP:corrinoid) adenosyltransferases ( ), catalyse the conversion of cobalamin (vitamin B12) into its coenzyme form, adenosylcobalamin (AdoCbl)or coenzyme B12 [ ]. AdoCbl contains an adenosyl moiety liganded to the cobalt ion of cobalamin via a covalent Co-C bond. AdoCbl is required as a cofactor fo...

[]

0

[ "PIRSF" ]

[ "PIRSF036411" ]

[ "ATR_PduO" ]

[ 904 ]

1

[]

0

[]

0

[ "PUB00006386", "PUB00013593", "PUB00015064", "PUB00035323", "PUB00035324", "PUB00100245" ]

[ "9311132", "11160088", "15317775", "16672609", "15516577", "27446048" ]

[ "Glycerol conversion to 1,3-propanediol by Clostridium pasteurianum: cloning and expression of the gene encoding 1,3-propanediol dehydrogenase.", "Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.", "The eutT gene of Salmonel...

[ 1997, 2001, 2004, 2006, 2004, 2016 ]

6

[]

0

null

[ "Bacteria" ]

[ 904 ]

1

[]

0

true

Family

Corrinoid adenosyltransferase PduO

PduO

9

IPR009223

9,223

Adenomatous polyposis coli protein repeat

APC_rpt

Repeat

3,057

false

This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin [ ].

[ "GO:0016055" ]

[ "Wnt signaling pathway" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05923" ]

[ "APC_r" ]

[ 3057 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-111465", "R-HSA-195253", "R-HSA-196299", "R-HSA-3769402", "R-HSA-4641262", "R-HSA-5339716", "R-HSA-5358747", "R-HSA-5358749", "R-HSA-5358751", "R-HSA-5358752", "R-HSA-5467333", "R-HSA-5467337", "R-HSA-5467340", "R-HSA-5467348", "R-HSA-5689896", "R-MMU-111465", "R-MMU-195253", ...

[ "REACTOME:R-HSA-111465", "REACTOME:R-HSA-195253", "REACTOME:R-HSA-196299", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-4641262", "REACTOME:R-HSA-5339716", "REACTOME:R-HSA-5358747", "REACTOME:R-HSA-5358749", "REACTOME:R-HSA-5358751", "REACTOME:R-HSA-5358752", "REACTOME:R-HSA-5467333", "REACTOME:R...

27

[ "1th1", "1v18" ]

2

[ "PUB00011912" ]

[ "9823329" ]

[ "Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin." ]

[ 1998 ]

1

[]

0

null

[ "Bilateria", "Methanolobus halotolerans", "Okeania hirsuta" ]

[ 3055, 1, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 7, 18, 7, 15 ]

5

true

Repeat

Adenomatous polyposis coli protein repeat

APC_rpt

8

IPR009224

9,224

SAMP

Repeat

2,514

false

This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin [ ].

[ "GO:0008013", "GO:0016055" ]

[ "beta-catenin binding", "Wnt signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05924" ]

[ "SAMP" ]

[ 2514 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-111465", "R-HSA-195253", "R-HSA-196299", "R-HSA-3769402", "R-HSA-4641262", "R-HSA-5339716", "R-HSA-5358747", "R-HSA-5358749", "R-HSA-5358751", "R-HSA-5358752", "R-HSA-5467333", "R-HSA-5467337", "R-HSA-5467340", "R-HSA-5467348", "R-HSA-5689896", "R-MMU-111465", "R-MMU-195253", ...

[ "REACTOME:R-HSA-111465", "REACTOME:R-HSA-195253", "REACTOME:R-HSA-196299", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-4641262", "REACTOME:R-HSA-5339716", "REACTOME:R-HSA-5358747", "REACTOME:R-HSA-5358749", "REACTOME:R-HSA-5358751", "REACTOME:R-HSA-5358752", "REACTOME:R-HSA-5467333", "REACTOME:R...

27

[ "1emu", "2rqu" ]

2

[ "PUB00011912" ]

[ "9823329" ]

[ "Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin." ]

[ 1998 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 2514 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 10, 7, 15 ]

4

true

Repeat

SAMP

8

IPR009225

9,225

Bacteriophage head completion protein GpL

Phage_head_completion_GpL

Family

3,484

false

This entry represents the head completion protein GpL found in bacteriophages and prophages. GpL allows the completion of filled heads by rendering newly packaged DNA in the heads resistant to DNase. The protein is thought to bind to DNA filled capsids [ ].

[ "GO:0019069" ]

[ "viral capsid assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05926" ]

[ "Phage_GPL" ]

[ 3484 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00011914" ]

[ "1837355" ]

[ "Nucleotide sequence of the DNA packaging and capsid synthesis genes of bacteriophage P2." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Capitella teleta", "Halolamina pelagica", "Viruses", "metagenomes" ]

[ 3307, 1, 1, 166, 9 ]

5

[]

0

true

Family

Bacteriophage head completion protein GpL

Phage_head_completion_GpL

4

IPR009227

9,227

Zea mays MURB-like

Zea_mays_MuDR

Family

22

false

This family consists of several Zea mays (Maize) specific MURB-like proteins. The transposition of Mu elements underlying Mutator activity in maize requires a transcriptionally active MuDR element. Despite variation in MuDR copy number and RNA levels in Mutator lines, transposition events are consistently late in plant...

[]

0

[ "PFAM" ]

[ "PF05928" ]

[ "Zea_mays_MuDR" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00011916" ]

[ "11251096" ]

[ "Expression and post-transcriptional regulation of maize transposable element MuDR and its derivatives." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 22 ]

1

[ "Zea mays" ]

[ 20 ]

1

true

Family

Zea mays MURB-like

Zea_mays_MuDR

6

IPR009228

9,228

Capsid scaffolding protein GpO

Capsid_scaffold_GpO

Family

3,795

false

The bacteriophage P2 capsid is formed by multiple copies of the capsid protein GpN. The scaffolding protein GpO, which is essential for the assembly of this capsid, consists of an N-terminal serine protease domain and a C-terminal scaffolding domain [ , ]. During capsid assembly, GpO interacts with GpN via the N-termin...

[ "GO:0019069" ]

[ "viral capsid assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05929" ]

[ "Phage_GPO" ]

[ 3795 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00011914", "PUB00056601" ]

[ "1837355", "19064277" ]

[ "Nucleotide sequence of the DNA packaging and capsid synthesis genes of bacteriophage P2.", "Functional domains of the bacteriophage P2 scaffolding protein: identification of residues involved in assembly and protease activity." ]

[ 1991, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3616, 4, 166, 9 ]

4

[]

0

true

Family

Capsid scaffolding protein GpO

Capsid_scaffold_GpO

2

IPR009229

9,229

AgrD, cyclic lactone autoinducer peptide

AgrD

Family

1,951

false

Members of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterised is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histi...

[]

0

[ "PFAM", "SMART", "NCBIFAM" ]

[ "PF05931", "SM00794", "TIGR04223" ]

[ "AgrD", "AgrD", "quorum_AgrD" ]

[ 167, 156, 1950 ]

3

[ "GP" ]

[ "GenProp1011" ]

[ "GP:GenProp1011" ]

1

[]

0

[ "PUB00011918", "PUB00159283", "PUB00159284" ]

[ "11807079", "19520867", "15001569" ]

[ "High genetic variability of the agr locus in Staphylococcus species.", "Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis.", "Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in S...

[ 2002, 2009, 2004 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1919, 6, 26 ]

3

[]

0

true

Family

AgrD, cyclic lactone autoinducer peptide

AgrD

1

IPR009230

9,230

ATP synthase protein 8, fungal type

ATP_synth_su8_fun

Family

945

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0015078", "GO:0015986", "GO:0045259" ]

[ "proton transmembrane transporter activity", "proton motive force-driven ATP synthesis", "proton-transporting ATP synthase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF05933", "PTHR36101" ]

[ "Fun_ATP-synt_8", "" ]

[ 945, 758 ]

2

[]

0

[ "6b2z", "6b8h", "6cp3", "6cp5", "6cp6", "6cp7", "6wtd", "7tjy", "7tjz", "7tk0", "7tk1", "7tk2", "7tk3", "7tk4", "7tk5", "7tk6", "7tk7", "7tk8", "7tk9", "7tka", "7tkb", "7tkc", "7tkd", "7tke", "7tkf", "7tkg", "7tkh", "7tki", "7tkj", "7tkk", "7tkl", "7tkm"...

42

[ "PUB00009752", "PUB00020603", "PUB00020604", "PUB00020648", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00081957" ]

[ "11309608", "15473999", "15078220", "12626501", "20450191", "18937357", "1385979", "9741106", "10838056" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "The molecular neighborhood ...

[ 2001, 2004, 2004, 2003, 2010, 2008, 1992, 1998, 2000 ]

9

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 940 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

ATP synthase protein 8, fungal type

ATP_synth_su8_fun

2

IPR009232

9,232

EB-1 binding

EB1-bd

Domain

1,387

false

This region at the C terminus of the APC proteins binds the microtubule-associating protein EB-1 [ ]. At the C terminus of the alignment is also a PDZ-binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins (e.g. ).

[ "GO:0008013", "GO:0016055" ]

[ "beta-catenin binding", "Wnt signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05937" ]

[ "EB1_binding" ]

[ 1387 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-111465", "R-HSA-195253", "R-HSA-196299", "R-HSA-3769402", "R-HSA-4641262", "R-HSA-5339716", "R-HSA-5358747", "R-HSA-5358749", "R-HSA-5358751", "R-HSA-5358752", "R-HSA-5467333", "R-HSA-5467337", "R-HSA-5467340", "R-HSA-5467348", "R-HSA-5689896", "R-MMU-111465", "R-MMU-195253", ...

[ "REACTOME:R-HSA-111465", "REACTOME:R-HSA-195253", "REACTOME:R-HSA-196299", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-4641262", "REACTOME:R-HSA-5339716", "REACTOME:R-HSA-5358747", "REACTOME:R-HSA-5358749", "REACTOME:R-HSA-5358751", "REACTOME:R-HSA-5358752", "REACTOME:R-HSA-5467333", "REACTOME:R...

27

[]

0

[ "PUB00011922" ]

[ "11514192" ]

[ "The adenomatous polyposis coli protein: in the limelight out at the edge." ]

[ 2001 ]

1

[]

0

null

[ "Vertebrata" ]

[ 1387 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 3, 9 ]

4

true

Domain

EB-1 binding

EB1-bd

3

IPR009233

9,233

Competence pheromone ComX, Bacillus-type

Competence_ComX_Bacillus

Family

296

false

Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...

[]

0

[ "PFAM" ]

[ "PF05952" ]

[ "ComX" ]

[ 296 ]

1

[]

0

[]

0

[ "PUB00011930", "PUB00052316" ]

[ "12067344", "8901420" ]

[ "Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants.", "Who's competent and when: regulation of natural genetic competence in bacteria." ]

[ 2002, 1996 ]

2

[]

0

null

[ "Bacillota" ]

[ 296 ]

1

[]

0

true

Family

Competence pheromone ComX, Bacillus-type

Competence_ComX_Bacillus

3

IPR009234

9,234

Adenomatous polyposis coli protein basic domain

APC_basic_dom

Domain

2,056

false

This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules [ ].

[ "GO:0008017", "GO:0016055" ]

[ "microtubule binding", "Wnt signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05956" ]

[ "APC_basic" ]

[ 2056 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-111465", "R-HSA-195253", "R-HSA-196299", "R-HSA-3769402", "R-HSA-4641262", "R-HSA-5339716", "R-HSA-5358747", "R-HSA-5358749", "R-HSA-5358751", "R-HSA-5358752", "R-HSA-5467333", "R-HSA-5467337", "R-HSA-5467340", "R-HSA-5467348", "R-HSA-5689896", "R-MMU-111465", "R-MMU-195253", ...

[ "REACTOME:R-HSA-111465", "REACTOME:R-HSA-195253", "REACTOME:R-HSA-196299", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-4641262", "REACTOME:R-HSA-5339716", "REACTOME:R-HSA-5358747", "REACTOME:R-HSA-5358749", "REACTOME:R-HSA-5358751", "REACTOME:R-HSA-5358752", "REACTOME:R-HSA-5467333", "REACTOME:R...

27

[]

0

[ "PUB00011932" ]

[ "9654054" ]

[ "A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau." ]

[ 1998 ]

1

[]

0

null

[ "Vertebrata" ]

[ 2056 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 9, 6, 15 ]

4

true

Domain

Adenomatous polyposis coli protein basic domain

APC_basic_dom

3

IPR009235

9,235

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf146

AcMNPV_Orf146

Family

151

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf146; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF05959" ]

[ "DUF884" ]

[ 151 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 151 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf146

AcMNPV_Orf146

9

IPR009236

9,236

Chordopoxvirus A13L

Chordopox_A13L

Family

137

false

The major components of the vaccinia virus membrane consists of the A17L, A14L, A13L, L1L, D8R, and H3L proteins. This entry represents the A13L protein, also known as Virion membrane protein OPG139, which is 70 amino acids long and has an N-terminal hydrophobic region that is implicated in cotranslational insertion of...

[]

0

[ "PFAM" ]

[ "PF05961" ]

[ "Chordopox_A13L" ]

[ 137 ]

1

[]

0

[]

0

[ "PUB00075392" ]

[ "15280497" ]

[ "Vaccinia virus morphogenesis: a13 phosphoprotein is required for assembly of mature virions." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Poxviridae" ]

[ 6, 7, 124 ]

3

[]

0

true

Family

Chordopoxvirus A13L

Chordopox_A13L

7

IPR009238

9,238

Chordopoxvirus A33R

Chordopox_A33R

Family

151

false

This family consists of several Chordopoxvirus A33R proteins. A33R, also known as Protein OPG161, plays a role in promoting Ab-resistant cell-to-cell spread of virus [ ] and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV) and, subsequently, the production ...

[]

0

[ "PFAM" ]

[ "PF05966" ]

[ "Chordopox_A33R" ]

[ 151 ]

1

[]

0

[ "3k7b", "4lqf", "4lu5", "4m1g", "8xa4", "9kyz", "9msn", "9mso", "9msp" ]

9

[ "PUB00011936", "PUB00011937", "PUB00103652", "PUB00103653", "PUB00103654" ]

[ "11752718", "12634370", "23255618", "31941777", "11119600" ]

[ "Antibody-sensitive and antibody-resistant cell-to-cell spread by vaccinia virus: role of the A33R protein in antibody-resistant spread.", "Mapping and functional analysis of interaction sites within the cytoplasmic domains of the vaccinia virus A33R and A36R envelope proteins.", "Transport and stability of the...

[ 2002, 2003, 2013, 2020, 2001 ]

5

[]

0

null

[ "Bilateria", "Poxviridae" ]

[ 7, 144 ]

2

[]

0

true

Family

Chordopoxvirus A33R

Chordopox_A33R

6

IPR009239

9,239

Bacillus PapR

Bacillus_PapR

Family

163

false

This family consists of the Bacillus species-specific PapR protein. The papR gene belongs to the PlcR regulon and is located 70 bp downstream from plcR. It encodes a 48-amino-acid peptide. Disruption of the papR gene abolishes expression of the PlcR regulon, resulting in a large decrease in haemolysis and virulence in ...

[]

0

[ "PFAM" ]

[ "PF05968" ]

[ "Bacillus_PapR" ]

[ 163 ]

1

[]

0

[]

0

[ "PUB00011938" ]

[ "12198157" ]

[ "A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group." ]

[ 2002 ]

1

[]

0

null

[ "Bacillus" ]

[ 163 ]

1

[]

0

true

Family

Bacillus PapR

Bacillus_PapR

3

IPR009241

9,241

Toxin HigB-like

HigB-like

Family

14,248

false

This entry consists of putative toxins, including probable endoribonuclease HigB1 [ ]. HigB1 is a toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) module. Upon expression in M.smegmatis it inhibits colony formation and cell growth [ , ].

[]

0

[ "PFAM" ]

[ "PF05973" ]

[ "Gp49" ]

[ 14248 ]

1

[ "GP" ]

[ "GenProp0321" ]

[ "GP:GenProp0321" ]

1

[ "6af3", "6af4", "7awk", "7nbu" ]

4

[ "PUB00067485", "PUB00077565" ]

[ "20011113", "23927792" ]

[ "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution.", "Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of t...

[ 2009, 2013 ]

2

[]

[ "IPR014056" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 13974, 16, 5, 16, 237 ]

5

[]

0

true

Family

Toxin HigB-like

HigB-like

1

IPR009242

9,242

Protein of unknown function DUF896

DUF896

Family

4,730

false

In Bacillus subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC [ ]. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in Gram-positive Firmicutes. Structures show ...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01103", "PF05979", "PTHR37300" ]

[ "UPF0291", "DUF896", "" ]

[ 4466, 4730, 4661 ]

3

[]

0

[ "2hep", "2jvd", "3bhp" ]

3

[ "PUB00047592", "PUB00053936", "PUB00070793" ]

[ "18431750", "12581363", "21348639" ]

[ "Solution NMR structure of the SOS response protein YnzC from Bacillus subtilis.", "Identification of a protein, YneA, responsible for cell division suppression during the SOS response in Bacillus subtilis.", "Ab initio modeling led annotation suggests nucleic acid binding function for many DUFs." ]

[ 2008, 2003, 2011 ]

3

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 4697, 2, 31 ]

3

[]

0

true

Family

Protein of unknown function DUF896

DUF896

4

IPR009245

9,245

Herpesvirus UL22A

Cytomegalo_UL22A

Family

42

false

This family consists of several Cytomegalovirus UL20A proteins. UL20A is thought to be a glycoprotein [ ].

[]

0

[ "PFAM" ]

[ "PF05984" ]

[ "Cytomega_UL20A" ]

[ 42 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[]

0

[ "PUB00011941" ]

[ "11928987" ]

[ "Characterisation of transcripts from the human cytomegalovirus genes TRL7, UL20a, UL36, UL65, UL94, US3 and US34." ]

[ 2002 ]

1

[]

0

null

[ "Cytomegalovirus" ]

[ 42 ]

1

[]

0

true

Family

Herpesvirus UL22A

Cytomegalo_UL22A

5

IPR009246

9,246

Ethanolamine ammonia-lyase small subunit

EutC

Family

6,601

false

This family consists of several bacterial ethanolamine ammonia-lyase small subunit (EutC) sequences. Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia [ ].

[ "GO:0008851", "GO:0006520" ]

[ "ethanolamine ammonia-lyase activity", "amino acid metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_00601", "NF003971", "PF05985", "PIRSF018982", "PTHR39330" ]

[ "EutC", "PRK05465.1", "EutC", "EutC", "" ]

[ 6218, 6233, 6596, 5881, 6403 ]

5

[ "EC", "GP", "GP", "GP", "GP" ]

[ "4.3.1.7", "GenProp0292", "GenProp0294", "GenProp1167", "GenProp1762" ]

[ "EC:4.3.1.7", "GP:GenProp0292", "GP:GenProp0294", "GP:GenProp1167", "GP:GenProp1762" ]

5

[ "3abo", "3abq", "3abr", "3abs", "3any", "3ao0", "5ysn", "5ysr", "7xrm", "7xrn" ]

10

[ "PUB00002563" ]

[ "2197274" ]

[ "Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 6524, 17, 29, 31 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ethanolamine ammonia-lyase small subunit

EutC

4

IPR009247

9,247

Chordopoxvirus A35R

Chordopox_A35R

Family

111

false

This family consists of several Chordopoxvirus sequences homologous to the Vaccinia virus A35R protein, also known as Protein OPG163, which affects the expression of MHC class II molecules on the surface of host antigen presenting cells (APCs) [ , ].

[]

0

[ "PFAM" ]

[ "PF05989" ]

[ "Chordopox_A35R" ]

[ 111 ]

1

[]

0

[]

0

[ "PUB00103655", "PUB00103656" ]

[ "19828608", "19954808" ]

[ "The poxvirus A35 protein is an immunoregulator.", "Vaccinia virus A35R inhibits MHC class II antigen presentation." ]

[ 2010, 2010 ]

2

[]

0

null

[ "Poxviridae" ]

[ 111 ]

1

[]

0

true

Family

Chordopoxvirus A35R

Chordopox_A35R

3

IPR009248

9,248

SbmA/BacA-like

SbmA_BacA

Family

2,747

false

The Rhizobium meliloti (Sinorhizobium meliloti) bacA gene encodes a function that is essential for bacterial differentiation into bacteroids within plant cells in the symbiosis between R. meliloti and alfalfa. An Escherichia coli homologue of BacA, SbmA, is implicated in the uptake of microcins and bleomycin. This fami...

[ "GO:1904680", "GO:0015833", "GO:0016020" ]

[ "peptide transmembrane transporter activity", "peptide transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05992" ]

[ "SbmA_BacA" ]

[ 2747 ]

1

[]

0

[ "7p34", "9g3d", "9g3e", "9g3f", "9g3g", "9g4e", "9g4f" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Marine Group I thaumarchaeote", "metagenomes" ]

[ 2609, 81, 3, 54 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

SbmA/BacA-like

SbmA_BacA

3

IPR009249

9,249

Ferredoxin-dependent bilin reductase

Ferredoxin-dep_bilin_Rdtase

Family

1,821

false

This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase (PebA) and phycoerythrobilin:ferredoxin oxidoreductase (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting p...

[ "GO:0016636", "GO:0050897", "GO:0010024" ]

[ "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "cobalt ion binding", "phytochromobilin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PANTHER" ]

[ "PF05996", "PTHR34557" ]

[ "Fe_bilin_red", "" ]

[ 1791, 1760 ]

2

[ "EC" ]

[ "1.3.7" ]

[ "EC:1.3.7" ]

1

[ "2d1e", "2dke", "2g18", "2vck", "2vcl", "2vgr", "2x9i", "2x9j", "2x9o", "3ajg", "3ajh", "3f0l", "3f0m", "3i8u", "3i94", "3i95", "3nb8", "3nb9", "4eoc", "4eod", "4eoe", "4qcd", "5b4h", "5b4i", "5b4j", "5owg", "6kmd", "6kme", "6qwq", "6qx6", "7yk9", "7ykb"...

35

[ "PUB00011945" ]

[ "11283349" ]

[ "Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms." ]

[ 2001 ]

1

[]

[ "IPR022827", "IPR022870", "IPR023658" ]

0

3

0

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 735, 1051, 26, 9 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 4, 7 ]

3

true

Family

Ferredoxin-dependent bilin reductase

Ferredoxin-dep_bilin_Rdtase

2

IPR009251

9,251

Alpha-2,3-sialyltransferase

A-2_3-sialyltransferase

Family

224

false

This entry represents several alpha-2,3-sialyltransferase ( ) proteins, most of which are found in the food-borne pathogen Campylobacter jejuni. Sialyltransferases transfer a sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to terminal positions of various key glycoconjugates, which ...

[]

0

[ "PFAM" ]

[ "PF06002" ]

[ "CST-I" ]

[ 224 ]

1

[]

0

[ "1ro7", "1ro8", "2drj", "2p2v", "2p56", "2wqq", "2x61", "2x62", "2x63", "9c08" ]

10

[ "PUB00030744" ]

[ "14730352" ]

[ "Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria" ]

[ 224 ]

1

[]

0

true

Family

Alpha-2,3-sialyltransferase

A-2_3-sialyltransferase

8

IPR009254

9,254

Laminin alpha, domain I

Laminin_aI

Domain

5,010

false

Laminins are glycoproteins that are major constituents of the basement membrane of cells. Laminins are trimeric molecules; laminin-1 is an alpha1 beta1 gamma1 trimer. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [ ]. Binding t...

[ "GO:0005102", "GO:0030155", "GO:0030334", "GO:0045995" ]

[ "signaling receptor binding", "regulation of cell adhesion", "regulation of cell migration", "regulation of embryonic development" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process" ]

4

[ "PFAM" ]

[ "PF06008" ]

[ "Laminin_I" ]

[ 5010 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1474228", "R-HSA-2022090", "R-HSA-2214320", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-373760", "R-HSA-446107", "R-HSA-6785807", "R-HSA-8874081", "R-HSA-9619665", "R-HSA-9638630", "R-HSA-9913351", "R-HSA-9925563", "R-MMU-3000157", "R-MMU-8874081", "R-MMU-9913351...

[ "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-2214320", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-373760", "REACTOME:R-HSA-446107", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8874081", "REACTOME:R-HSA-9619665", "REACTOME:...

17

[]

0

[ "PUB00012222" ]

[ "3182802" ]

[ "Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains." ]

[ 1988 ]

1

[]

0

null

[ "Bacillota", "Eukaryota" ]

[ 5, 5005 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 2, 20, 9, 22 ]

5

true

Domain

Laminin alpha, domain I

Laminin_aI

2

IPR009256

9,256

YqgQ-like

Family

2,361

false

This family consists of short proteins predominantly found in Firmicutes, including Uncharacterized protein YqgQ from Bacillus subtilis. YqgQ folds into a three-helical bundle, with the helix order being left-handed and with the third helix flanked by a loop. Based on sequence and structural homology, this protein is t...

[]

0

[ "PFAM" ]

[ "PF06014" ]

[ "YqgQ-like" ]

[ 2361 ]

1

[]

0

[ "2nn4" ]

1

[ "PUB00101010" ]

[ "20057058" ]

[ "Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria" ]

[ 2361 ]

1

[]

0

true

Family

YqgQ-like

9

IPR009257

9,257

Chordopoxvirus A30L

Chordopox_A30L

Family

105

false

This family consists of several short Chordopoxvirus proteins which are homologous to the A30L protein of Vaccinia virus, also known as Protein OPG157. The vaccinia virus A30L protein is required for the association of electron-dense, granular, proteinaceous material with the concave surfaces of crescent membranes, an ...

[]

0

[ "PFAM" ]

[ "PF06015" ]

[ "Chordopox_A30L" ]

[ 105 ]

1

[]

0

[]

0

[ "PUB00012223", "PUB00012257" ]

[ "12610117", "11390577" ]

[ "Vaccinia virus G7L protein Interacts with the A30L protein and is required for association of viral membranes with dense viroplasm to form immature virions.", "Vaccinia virus A30L protein is required for association of viral membranes with dense viroplasm to form immature virions." ]

[ 2003, 2001 ]

2

[]

0

null

[ "Biomaibacter acetigenes", "Dreissena polymorpha", "Poxviridae" ]

[ 1, 1, 103 ]

3

[]

0

true

Family

Chordopoxvirus A30L

Chordopox_A30L

8

IPR009258

9,258

Bacteriophage T4, Gp30.8

Phage_T4_Gp30.8

Family

237

false

This entry is represented by Bacteriophage T4, Gp30.8; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF06019" ]

[ "Phage_30_8" ]

[ 237 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses" ]

[ 237 ]

1

[]

0

true

Family

Bacteriophage T4, Gp30.8

Phage_T4_Gp30.8

4

IPR009259

9,259

Drosophila roughex

Roughex

Family

74

false

This family consists of several roughex (RUX) proteins specific to Drosophila species. Roughex can influence the intracellular distribution of cyclin A and is therefore defined as a distinct and specialised cell cycle inhibitor for cyclin A-dependent kinase activity [ ]. Rux is though to regulate the metaphase to anaph...

[]

0

[ "PFAM" ]

[ "PF06020" ]

[ "Roughex" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00012227", "PUB00012228" ]

[ "11027291", "11231149" ]

[ "Roughex mediates G(1) arrest through a physical association with cyclin A.", "The cyclin-dependent kinase inhibitor Roughex is involved in mitotic exit in Drosophila." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Drosophilinae" ]

[ 74 ]

1

[ "Drosophila melanogaster" ]

[ 5 ]

1

true

Family

Drosophila roughex

Roughex

2

IPR009260

9,260

CRISPR-associated exonuclease Csa1

CRISPR-ass_Csa1

Family

190

false

CRISPR (clustered regularly interspaced short palindromic repeats) elements and cas (CRISPR-associated) genes are widespread in Bacteria and Archaea. The CRISPR/Cas system operates as a defense mechanism against mobile genetic elements (i.e., viruses or plasmids). Csa1 is part of the archaeal subtype I-A system. Cas1 h...

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF06023", "PIRSF009226", "TIGR01896" ]

[ "Csa1", "UCP009226", "cas_AF1879" ]

[ 190, 77, 171 ]

3

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0319" ]

[ "GP:GenProp0021", "GP:GenProp0319" ]

2

[]

0

[ "PUB00073621" ]

[ "22408157" ]

[ "Characterization of the CRISPR/Cas subtype I-A system of the hyperthermophilic crenarchaeon Thermoproteus tenax." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 155, 33, 2 ]

3

[]

0

true

Family

CRISPR-associated exonuclease Csa1

CRISPR-ass_Csa1

4

IPR009262

9,262

Solute carrier family 35 member SLC35F1/F2/F6

SLC35_F1/F2/F6

Family

9,047

false

This entry contains some of the solute carrier family 35 members, including SLC35F1, SLC35F2 and SLC35F6. In humans, SLC35F6 is involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. It promotes pancreatic ductal adenocarcinoma (PDAC) cell growth and may play a...

[ "GO:0022857", "GO:0055085", "GO:0016020" ]

[ "transmembrane transporter activity", "transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06027" ]

[ "SLC35F" ]

[ 9047 ]

1

[]

0

[]

0

[ "PUB00066821" ]

[ "19154410" ]

[ "Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis." ]

[ 2009 ]

1

[]

0

null

[ "Bacillati", "Eukaryota", "Siphoviridae sp. ctmpG14", "marine metagenome" ]

[ 7, 9038, 1, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea...

[ 26, 4, 6, 7, 5, 1, 17, 10, 1, 33 ]

10

true

Family

Solute carrier family 35 member SLC35F1/F2/F6

SLC35_F1/F2/F6

6

IPR009263

9,263

SERTA domain

SERTA_dom

Domain

5,206

false

The SERTA (for SEI-1, RBT-1, and TARA) domain is a motif of ~47 residues corresponding to the largest conserved region among TRIP-Br (transcriptional regulator interacting with the PHD-bromodomain) proteins, an evolutionarily conserved family restricted to higher eukaryotes. In proteins of the TRIP-Br family, the SERTA...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF06031", "PS51053" ]

[ "SERTA", "SERTA" ]

[ 5071, 5182 ]

2

[ "PROSITEDOC" ]

[ "PDOC51053" ]

[ "PROSITEDOC:PDOC51053" ]

1

[ "9n0z" ]

1

[ "PUB00012229" ]

[ "11861561" ]

[ "The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Streptomyces" ]

[ 5202, 4 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 21, 5, 8, 11, 16 ]

5

true

Domain

SERTA domain

SERTA_dom

2

IPR009264

9,264

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf57

AcMNPV_Orf57

Family

104

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf57; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF06033" ]

[ "DUF918" ]

[ 104 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphabaculovirus" ]

[ 104 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf57

AcMNPV_Orf57

5

IPR009265

9,265

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf29

AcMNPV_Orf29

Family

128

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf29. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several short baculovirus proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06034" ]

[ "DUF919" ]

[ 128 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae", "Ignelater luminosus", "Pseudomonadati", "metagenomes" ]

[ 107, 1, 16, 4 ]

4

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf29

AcMNPV_Orf29

3

IPR009266

9,266

Adenovirus E3

Adeno_E3

Family

156

false

This family consists of several Adenovirus E3 proteins. The E3 protein does not seem to be essential for virus replication in cultured cells suggesting that the protein may function in virus-host interactions [ ].

[]

0

[ "PFAM" ]

[ "PF06040" ]

[ "Adeno_E3" ]

[ 156 ]

1

[]

0

[]

0

[ "PUB00012232" ]

[ "7769690" ]

[ "Region E3 of subgroup B human adenoviruses encodes a 16-kilodalton membrane protein that may be a distant analog of the E3-6.7K protein of subgroup C adenoviruses." ]

[ 1995 ]

1

[]

0

null

[ "Mastadenovirus", "Plasmodium gallinaceum", "Streptomyces bauhiniae" ]

[ 154, 1, 1 ]

3

[]

0

true

Family

Adenovirus E3

Adeno_E3

4

IPR009267

9,267

Putative nucleotidyltransferase

NTP_transf_6

Family

4,812

false

This family consists of several hypothetical bacterial proteins of unknown function. This family was recently identified as belonging to the nucleotidyltransferase superfamily [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06042", "PTHR39166" ]

[ "NTP_transf_6", "" ]

[ 4811, 4758 ]

2

[]

0

[ "2la3" ]

1

[ "PUB00066751" ]

[ "19833706" ]

[ "Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4537, 263, 12 ]

3

[]

0

true

Family

Putative nucleotidyltransferase

NTP_transf_6

9

IPR009268

9,268

Reovirus P9-like

Reo_P9

Family

135

false

These proteins of unknown function are found in Rice black streaked dwarf virus (RBSDV) and other viruses.

[]

0

[ "PFAM" ]

[ "PF06043" ]

[ "Reo_P9" ]

[ 135 ]

1

[]

0

[ "3vjj", "5eft", "6uct", "7kvc", "7kvd" ]

5

[]

0

[]

0

null

[ "Fijivirus" ]

[ 135 ]

1

[]

0

true

Family

Reovirus P9-like

Reo_P9

6

IPR009269

9,269

NF-kappa-B-activating protein, C-terminal

NKAP_C

Domain

3,403

false

This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. It is the HDAC3 binding domain required for transcriptional repression [ ]. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell develop...

[ "GO:0003682" ]

[ "chromatin binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06047" ]

[ "Nkap_C" ]

[ 3403 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-72163", "R-DME-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-DDI-72163", "REACTOME:R-DME-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

5

[ "6qdv", "7w5b", "8c6j", "9fmd" ]

4

[ "PUB00075800", "PUB00075801", "PUB00075802" ]

[ "19409814", "21624937", "23481390" ]

[ "NKAP is a transcriptional repressor of notch signaling and is required for T cell development.", "NKAP is required for T cell maturation and acquisition of functional competency.", "The transcriptional repressor NKAP is required for the development of iNKT cells." ]

[ 2009, 2011, 2013 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3403 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 1, 1, 3, 2, 4, 6, 4 ]

9

true

Domain

NF-kappa-B-activating protein, C-terminal

NKAP_C

2

IPR009270

9,270

Domain of unknown function DUF927

DUF927

Domain

4,023

false

This entry represents a domain found in bacterial proteins of unknown function. The crystal stucture has been solved for a protein containing this domain [ ].

[]

0

[ "PFAM" ]

[ "PF06048" ]

[ "DUF927" ]

[ 4023 ]

1

[]

0

[ "5dgk", "8tch" ]

2

[ "PUB00085154" ]

[ "27571176" ]

[ "Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Viruses", "unclassified sequences" ]

[ 3899, 4, 29, 57, 34 ]

5

[]

0

true

Domain

Domain of unknown function DUF927

DUF927

6

IPR009271

9,271

Coagulation factor V, LSPD

Coagulation_factor_V_LSPD

Repeat

55

false

The name LSPD derives from the conserved residues in the middle of the repeat. These repeats are found in coagulation factor V and occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation [ ]. Coagulation factor V is a ...

[ "GO:0007596" ]

[ "blood coagulation" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06049" ]

[ "LSPR" ]

[ 55 ]

1

[]

0

[]

0

[ "PUB00012236" ]

[ "11229814" ]

[ "Porcine factor V: cDNA cloning, gene mapping, three-dimensional protein modeling of membrane binding sites and comparative anatomy of domains." ]

[ 2001 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 55 ]

1

[]

0

true

Repeat

Coagulation factor V, LSPD

Coagulation_factor_V_LSPD

5

IPR009272

9,272

Protein of unknown function DUF929

DUF929

Family

402

false

This is a family of proteins from the archaeon Sulfolobus, with undetermined function.

[]

0

[ "PFAM" ]

[ "PF06053" ]

[ "DUF929" ]

[ 402 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 216, 165, 21 ]

3

[]

0

true

Family

Protein of unknown function DUF929

DUF929

5

IPR009273

9,273

Protein of unknown function DUF930

DUF930

Family

1,215

false

This is a family of proteins with undetermined function from bacteria, mainly from the Rhizobiales order.

[]

0

[ "PFAM" ]

[ "PF06059" ]

[ "DUF930" ]

[ 1215 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 1214, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF930

DUF930

9

IPR009274

9,274

Host-nuclease inhibitor Gam

Gam

Family

447

false

This superfamily represents the host-nuclease inhibitor protein Gam. Structurally, it consists of 4 α helices, 2 long and 2 short. Within bacteriophage lambda protein Gam, one of the long helices (H4) acts as a dimerisation interface to form an antiparallel helix. The two short helices (H2 and H3) from each dimer form ...

[ "GO:0060703" ]

[ "deoxyribonuclease inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06064" ]

[ "Gam" ]

[ 447 ]

1

[]

0

[ "2uuz", "2uv1", "5mbv" ]

3

[ "PUB00042446" ]

[ "17544443" ]

[ "The crystal structure of lambda-Gam protein suggests a model for RecBCD inhibition." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Timema douglasi", "Viruses", "metagenomes" ]

[ 378, 1, 66, 2 ]

4

[]

0

true

Family

Host-nuclease inhibitor Gam

Gam

5

IPR009275

9,275

SepZ

Family

78

false

SepZ is a component of the type III secretion system use in bacteria. SepZ is a gene within the enterocyte effacement locus. SepZ mutants exhibit reduced invasion efficiency and lack of tyrosine phosphorylation of Hp90 [ ].

[]

0

[ "PFAM" ]

[ "PF06066" ]

[ "SepZ" ]

[ 78 ]

1

[]

0

[]

0

[ "PUB00012247" ]

[ "8878013" ]

[ "Attaching and effacing of host cells by enteropathogenic Escherichia coli in the absence of detectable tyrosine kinase mediated signal transduction." ]

[ 1996 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 78 ]

1

[]

0

true

Family

SepZ

3

IPR009278

9,278

Herpesvirus US9

Herpes_US9

Family

130

false

This family consists of several US9 and related proteins from the Alphaherpesviruses. The function of the US9 protein is unknown although in Bovine herpesvirus 5 Us9 is essential for the anterograde spread of the virus from the olfactory mucosa to the bulb [ ]. Together with the gE/gI heterodimer, US9 is involved in th...

[ "GO:0075733" ]

[ "intracellular transport of virus" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06072" ]

[ "Herpes_US9" ]

[ 130 ]

1

[]

0

[]

0

[ "PUB00012252", "PUB00078891" ]

[ "11907224", "18753205" ]

[ "Bovine herpesvirus 5 (BHV-5) Us9 is essential for BHV-5 neuropathogenesis.", "Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons." ]

[ 2002, 2008 ]

2

[]

0

null

[ "Alphaherpesvirinae", "Bacteria" ]

[ 128, 2 ]

2

[]

0

true

Family

Herpesvirus US9

Herpes_US9

8

IPR009279

9,279

Portal protein, Mu bacteriophage

Portal_Mu

Family

4,541

false

This entry represents phage portal proteins found in bacteriophage Mu (gp29 protein) and related proteins. This protein forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-...

[]

0

[ "PFAM" ]

[ "PF06074" ]

[ "Portal_Mu" ]

[ 4541 ]

1

[]

0

[ "8rka", "8rkb", "8rqe", "9c39", "9khx", "9knu" ]

6

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 23, 3420, 21, 909, 168 ]

5

[]

0

true

Family

Portal protein, Mu bacteriophage

Portal_Mu

5

IPR009280

9,280

Orthopoxvirus F14

Orthopox_F14

Family

65

false

This family consists of several short Orthopoxvirus F14 proteins. F14 is also known as Protein OPG058. The function of this protein is unknown.

[]

0

[ "PFAM" ]

[ "PF06076" ]

[ "Orthopox_F14" ]

[ 65 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Orthopoxvirus" ]

[ 65 ]

1

[]

0

true

Family

Orthopoxvirus F14

Orthopox_F14

6

IPR009281

9,281

Transmembrane protein 176A/B

TMEM176A/TMEM176B

Family

635

false

Transmembrane (TMEM)-176A and 176B proteins are closely related to MS4A (membrane-spanning 4-domains subfamily A) proteins [ ]. Their levels are significantly elevated in certain cancers [ , ]. TMEM176B (LR8, Torid, Clast1) is broadly expressed, but was up regulated in antigen presenting cells in a rat model of allogra...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR15756" ]

[ "" ]

[ 635 ]

1

[]

0

[]

0

[ "PUB00072763", "PUB00072801", "PUB00072803", "PUB00072804" ]

[ "20186339", "16095493", "12097419", "22244448" ]

[ "Phylogenetic analysis of the MS4A and TMEM176 gene families.", "Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts.", "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.", "Abnormal accumulation of human tra...

[ 2010, 2005, 2002, 2012 ]

4

[]

0

null

[ "Euteleostomi" ]

[ 635 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 7, 9, 5 ]

4

true

Family

Transmembrane protein 176A/B

TMEM176A/TMEM176B

9

IPR009282

9,282

Protein of unknown function DUF937

DUF937

Family

4,525

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06078" ]

[ "DUF937" ]

[ 4525 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 4490, 4, 4, 27 ]

4

[]

0

true

Family

Protein of unknown function DUF937

DUF937

8

IPR009283

9,283

Apyrase

Family

2,908

false

This family consists of several eukaryotic apyrase (or adenosine diphosphatase) proteins ( ), and related nucleoside diphosphatases ( ). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular ...

[ "GO:0005509", "GO:0017110" ]

[ "calcium ion binding", "nucleoside diphosphate phosphatase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06079", "PTHR13023" ]

[ "Apyrase", "" ]

[ 2895, 2847 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.1", "R-CEL-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695" ]

[ "EC:3.6.1", "REACTOME:R-CEL-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695" ]

5

[ "1s18", "1s1d", "2h2n", "2h2u" ]

4

[ "PUB00013405", "PUB00082592", "PUB00082593" ]

[ "12234496", "15248776", "9804829" ]

[ "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases.", "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and th...

[ 2002, 2004, 1998 ]

3

[]

0

null

[ "Eukaryota", "Pseudomonadota", "marine sediment metagenome" ]

[ 2872, 35, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 6, 2, 1, 5 ]

6

true

Family

Apyrase

8

IPR009285

9,285

Poxvirus A26L-like, N-terminal domain

Poxvirus_A26L-like_N

Domain

400

false

This entry represents a domain found at the N-terminal of A26L from Vaccinia virus, also known as Envelop protein OPG153, and similar sequences from poxvirus. A26L is an envelop protein that mediates acid-dependent endocytosis into host cells [ ]. It plays an important role in endocytic entry of the virus by acting as ...

[]

0

[ "PFAM" ]

[ "PF06086" ]

[ "Pox_A30L_A26L" ]

[ 400 ]

1

[]

0

[ "6a9s" ]

1

[ "PUB00012257", "PUB00103657", "PUB00103658", "PUB00103659" ]

[ "11390577", "22278246", "31220181", "20538855" ]

[ "Vaccinia virus A30L protein is required for association of viral membranes with dense viroplasm to form immature virions.", "Vaccinia mature virus fusion regulator A26 protein binds to A16 and G9 proteins of the viral entry fusion complex and dissociates from mature virions at low pH.", "Vaccinia viral A26 pro...

[ 2001, 2012, 2019, 2010 ]

4

[]

0

null

[ "Poxviridae" ]

[ 400 ]

1

[]

0

true

Domain

Poxvirus A26L-like, N-terminal domain

Poxvirus_A26L-like_N

2

IPR009286

9,286

Inositol-pentakisphosphate 2-kinase

Ins_P5_2-kin

Family

5,021

false

This is a family of inositol-pentakisphosphate 2-kinases (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA...

[ "GO:0005524", "GO:0035299" ]

[ "ATP binding", "inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06090", "PTHR14456" ]

[ "Ins_P5_2-kin", "" ]

[ 4998, 4777 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.158", "GenProp1249", "GenProp1509", "GenProp1574", "PWY-4661", "PWY-6361", "PWY-6362", "PWY-6369", "PWY-6372", "PWY-6554", "R-DRE-1855167", "R-DRE-1855191", "R-HSA-1855167", "R-HSA-1855191", "R-MMU-1855167", "R-MMU-1855191", "R-RNO-1855167", "R-RNO-1855191" ]

[ "EC:2.7.1.158", "GP:GenProp1249", "GP:GenProp1509", "GP:GenProp1574", "METACYC:PWY-4661", "METACYC:PWY-6361", "METACYC:PWY-6362", "METACYC:PWY-6369", "METACYC:PWY-6372", "METACYC:PWY-6554", "REACTOME:R-DRE-1855167", "REACTOME:R-DRE-1855191", "REACTOME:R-HSA-1855167", "REACTOME:R-HSA-185519...

18

[ "2xal", "2xam", "2xan", "2xao", "2xar", "3uds", "3udt", "3udz", "4aqk", "4axc", "4axd", "4axe", "4axf", "4lv7", "5mw8", "5mwl", "5mwm", "5xu6", "6fjk", "6fl3", "6fl8", "6gfg", "6gfh" ]

23

[ "PUB00044654" ]

[ "10960485" ]

[ "Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5021 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 26, 1, 2, 4, 3, 3, 1, 1, 4, 1, 1, 16 ]

12

true

Family

Inositol-pentakisphosphate 2-kinase

Ins_P5_2-kin

4

IPR009287

9,287

Transcription initiation Spt4

Spt4

Family

4,225

false

This family consists of several eukaryotic transcription initiation Spt4 proteins. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physic...

[ "GO:0008270", "GO:0006355", "GO:0140673", "GO:0005634" ]

[ "zinc ion binding", "regulation of DNA-templated transcription", "transcription elongation-coupled chromatin remodeling", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PIRSF", "PANTHER" ]

[ "PIRSF025023", "PTHR12882" ]

[ "Spt4", "" ]

[ 3204, 4225 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-112382", "R-CEL-113418", "R-CEL-674695", "R-CEL-6796648", "R-CEL-75955", "R-DME-112382", "R-DME-113418", "R-DME-674695", "R-DME-6796648", "R-DME-6807505", "R-DME-75955", "R-DRE-674695", "R-DRE-6796648", "R-HSA-112382", "R-HSA-113418", "R-HSA-167152", "R-HSA-167158", "R-HSA-1...

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-113418", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6796648", "REACTOME:R-CEL-75955", "REACTOME:R-DME-112382", "REACTOME:R-DME-113418", "REACTOME:R-DME-674695", "REACTOME:R-DME-6796648", "REACTOME:R-DME-6807505", "REACTOME:R-DME-75955", "REACTOME:R-DRE-67...

40

[ "2exu", "3h7h", "5oik", "5xon", "6gmh", "6gml", "6ir9", "6j4w", "6j4x", "6j4y", "6j4z", "6j50", "6j51", "6ted", "7nkx", "7nky", "7oky", "7und", "7wbv", "7wbw", "7wbx", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "7ycx", "8a3y", "8jh2", "8p4c"...

59

[ "PUB00012261" ]

[ "11182892" ]

[ "Control of eukaryotic transcription elongation." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4225 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 4, 1, 3, 6, 1, 1, 5 ]

12

true

Family

Transcription initiation Spt4

Spt4

1

IPR009288

9,288

Gamma-glutamylcyclotransferase, AIG2-like domain

AIG2-like_dom

Domain

20,224

false

This entry represents a domain found in a group of gamma-glutamyl cyclotransferases (GGCTs), including AIG2 from Arabidopsis. GGCT is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline [ , , ]. AIG2 is an Ar...

[]

0

[ "PFAM" ]

[ "PF06094" ]

[ "GGACT" ]

[ 20224 ]

1

[ "GP" ]

[ "GenProp1664" ]

[ "GP:GenProp1664" ]

1

[ "1v30", "1vkb", "1xhs", "2g0q", "2jqv", "2kl2", "2qik", "3jub", "3juc", "3jud" ]

10

[ "PUB00007984", "PUB00035714", "PUB00040892", "PUB00054829", "PUB00058764" ]

[ "8742710", "17462573", "16754964", "20110353", "20851126" ]

[ "Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.", "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.", "Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the ...

[ 1996, 2007, 2006, 2010, 2010 ]

5

[ "IPR013024" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 385, 11098, 8481, 103, 157 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 40, 1, 3, 6, 1, 3, 4, 1, 12, 4, 20 ]

11

true

Domain

Gamma-glutamylcyclotransferase, AIG2-like domain

AIG2-like_dom

9

IPR009289

9,289

Baculoviridae 8.2kDa

Baculo_8kDa

Family

82

false

Family of proteins from various Baculoviruses with undetermined function.

[]

0

[ "PFAM" ]

[ "PF06096" ]

[ "Baculo_8kDa" ]

[ 82 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 82 ]

1

[]

0

true

Family

Baculoviridae 8.2kDa

Baculo_8kDa

9

IPR009290

9,290

Radial spoke 3

Radial_spoke_3

Family

2,405

false

This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organisms from protists to humans. They are centred by precisely organised, microtubule-based structures, the axonemes. The axo...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06098", "PTHR21648" ]

[ "Radial_spoke_3", "" ]

[ 2376, 2305 ]

2

[]

0

[ "7jrj", "7jtk", "7jts", "7ju4", "8glv", "8j07", "8wzb", "8x2u", "9e5c", "9fqr" ]

10

[ "PUB00012262" ]

[ "12589069" ]

[ "Identification of a novel leucine-rich repeat protein as a component of flagellar radial spoke in the Ascidian Ciona intestinalis." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2405 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 7, 5 ]

5

true

Family

Radial spoke 3

Radial_spoke_3

5

IPR009291

9,291

Vacuolar protein sorting-associated protein 62

Vps62

Family

7,751

false

Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins [ ].

[]

0

[ "PFAM" ]

[ "PF06101" ]

[ "Vps62" ]

[ 7751 ]

1

[]

0

[ "6fbm" ]

1

[ "PUB00019468" ]

[ "12134085" ]

[ "Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Megaviridae environmental sample", "Methanosarcinales", "metagenomes" ]

[ 370, 7372, 1, 2, 6 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 62, 1, 16, 33 ]

4

true

Family

Vacuolar protein sorting-associated protein 62

Vps62

5

IPR009292

9,292

rRNA biogenesis protein RRP36

RRP36

Family

4,539

false

RRP36 is involved in the early processing steps of the pre-rRNA [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06102", "PTHR21738" ]

[ "RRP36", "" ]

[ 4502, 4353 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-DDI-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-DDI-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

7

[]

0

[ "PUB00077125" ]

[ "20038530" ]

[ "Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4539 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 1, 1, 2, 4, 1, 2, 3, 1, 1, 49 ]

12

true

Family

rRNA biogenesis protein RRP36

RRP36

8

IPR009293

9,293

Uncharacterised protein family UPF0478

UPF0478

Family

6,562

false

This family consists of bacterial sequences several of which are thought to be general stress proteins.

[]

0

[ "PFAM" ]

[ "PF06103" ]

[ "DUF948" ]

[ 6562 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Fungi", "metagenomes" ]

[ 6460, 3, 99 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0478

UPF0478

5

IPR009294

9,294

Gamma-secretase subunit Aph-1

Aph-1

Family

3,603

false

This family consists of several eukaryotic Aph-1 proteins. Aph-1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signalling paradigm and as a key step in the patho...

[ "GO:0016485", "GO:0043085", "GO:0016020" ]

[ "protein processing", "positive regulation of catalytic activity", "membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06105", "PTHR12889" ]

[ "Aph-1", "" ]

[ 3576, 3467 ]

2

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2017", "R-CEL-1251985", "R-CEL-3928665", "R-DME-1251985", "R-DME-3928665", "R-DRE-1251985", "R-DRE-193692", "R-DRE-3928665", "R-DRE-9839383", "R-HSA-1251985", "R-HSA-193692", "R-HSA-205043", "R-HSA-2122948", "R-HSA-2644606", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-3928665", ...

[ "GP:GenProp2017", "REACTOME:R-CEL-1251985", "REACTOME:R-CEL-3928665", "REACTOME:R-DME-1251985", "REACTOME:R-DME-3928665", "REACTOME:R-DRE-1251985", "REACTOME:R-DRE-193692", "REACTOME:R-DRE-3928665", "REACTOME:R-DRE-9839383", "REACTOME:R-HSA-1251985", "REACTOME:R-HSA-193692", "REACTOME:R-HSA-20...

29

[ "5a63", "5fn2", "5fn3", "5fn4", "5fn5", "6idf", "6iyc", "6lqg", "6lr4", "7c9i", "7d8x", "7y5t", "7y5x", "7y5z", "8im7", "8k8e", "8kco", "8kcp", "8kcs", "8kct", "8kcu", "8oqy", "8oqz", "8x52", "8x53", "8x54", "9k95" ]

27

[ "PUB00012265", "PUB00059246" ]

[ "12740439", "12110170" ]

[ "Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.", "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3603 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 2, 2, 10, 9, 3, 14, 6 ]

9

true

Family

Gamma-secretase subunit Aph-1

Aph-1

4

IPR009295

9,295

S. aureus uracil DNA glycosylase inhibitor

SAUGI

Family

225

false

Uracil-DNA glycosylase inhibitors are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 or SAUGI (for Staphylococcus aureus uracil-DNA glycosylase inhibitor) ( ) acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-remo...

[]

0

[ "PFAM" ]

[ "PF06106" ]

[ "SAUGI" ]

[ 225 ]

1

[]

0

[ "2kcd", "3wdg", "5ayr", "5ays", "6lyj", "6lyv", "8ain", "9iro" ]

8

[ "PUB00085049", "PUB00085050" ]

[ "24150946", "26980279" ]

[ "Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor.", "Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase." ]

[ 2014, 2016 ]

2

[]

0

null

[ "Bacillales", "human gut metagenome" ]

[ 223, 2 ]

2

[]

0

true

Family

S. aureus uracil DNA glycosylase inhibitor

SAUGI

9

IPR009296

9,296

Protein of unknown function DUF951

DUF951

Family

4,519

false

This family consists of several short hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06107", "PIRSF037263", "PTHR38455" ]

[ "DUF951", "DUF951_bac", "" ]

[ 4519, 4098, 4493 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Geodia barretti", "metagenomes" ]

[ 4467, 1, 51 ]

3

[]

0

true

Family

Protein of unknown function DUF951

DUF951

6

IPR009297

9,297

Protein of unknown function DUF952

DUF952

Family

7,779

false

This family consists of several hypothetical bacterial and plant proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06108", "PTHR34129" ]

[ "DUF952", "" ]

[ 7770, 6969 ]

2

[]

0

[ "2jqn", "2o0p", "2o0q" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Hyperionvirus sp.", "Stenosarchaea group", "metagenomes" ]

[ 5859, 1856, 2, 10, 52 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 6, 3 ]

4

true

Family

Protein of unknown function DUF952

DUF952

3

IPR009299

9,299

Gammaherpesvirus capsid

Herpes_capsid

Family

66

false

This family includes the small capsomere-interacting protein (SCP) from Gammaherpesviruses. By analogy with SCP from human herpesvirus 1, SCP forms a complex with the major capsid protein in the cytoplasm which is translocated to the nucleus. SCP decorates the outer surface of the capsid shell during capsid assembly, f...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04022", "PF06112" ]

[ "HSV_SCP_gammahv", "Herpes_capsid" ]

[ 58, 66 ]

2

[]

0

[ "6b43", "6ppb", "6ppd", "6pph", "6w19", "6w2d", "6w2e", "7bqx", "7br7", "7br8", "7bsi" ]

11

[]

0

[]

0

null

[ "Gammaherpesvirinae" ]

[ 66 ]

1

[]

0

true

Family

Gammaherpesvirus capsid

Herpes_capsid

3

IPR009300

9,300

Transcription activator RinB

Transcription_activator_RinB

Family

309

false

This family consists of several Staphylococcus aureus bacteriophage RinB proteins and related sequences from their host. The int gene of staphylococcal bacteriophage phi 11 is the only viral gene responsible for the integrative recombination of phi 11. rinA and rinB, are both required to activate expression of the int ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PFAM" ]

[ "NF047427", "PF06116" ]

[ "phage_activ_RinB", "RinB" ]

[ 308, 299 ]

2

[]

0

[]

0

[ "PUB00009648", "PUB00105396" ]

[ "8432703", "31402174" ]

[ "Cloning, sequencing, and genetic characterization of regulatory genes, rinA and rinB, required for the activation of staphylococcal phage phi 11 int expression.", "Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes." ]

[ 1993, 2019 ]

2

[]

0

null

[ "Bacteria", "Viruses" ]

[ 176, 133 ]

2

[]

0

true

Family

Transcription activator RinB

Transcription_activator_RinB

1

IPR009302

9,302

Tail length tape measure

Tail_length_tape_measure

Domain

769

false

This entry consists of the tail length tape measure protein from Bacteriophage HK97 and related sequences from Escherichia coli.

[]

0

[ "PFAM" ]

[ "PF06120" ]

[ "Phage_HK97_TLTM" ]

[ 769 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Pseudomonadota" ]

[ 30, 739 ]

2

[]

0

true

Domain

Tail length tape measure

Tail_length_tape_measure

6

IPR009303

9,303

Protein of unknown function DUF960

DUF960

Family

1,217

false

This family consists of several hypothetical proteins from several species of bacteria. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06124" ]

[ "DUF960" ]

[ 1217 ]

1

[]

0

[ "2r41" ]

1

[]

0

[]

0

null

[ "Bacteria", "Trichuris trichiura", "bioreactor metagenome" ]

[ 1214, 1, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF960

DUF960

1

IPR009304

9,304

Herpesvirus Latent membrane 2

Herpes_LAMP2

Family

66

false

This is a family of Kaposi's sarcoma-associated herpesvirus (HHV8) latent membrane protein. It includes protein K15, which plays a role in the modulation of host signaling pathways [ , ].

[]

0

[ "PFAM" ]

[ "PF06126" ]

[ "Herpes_LAMP2" ]

[ 66 ]

1

[]

0

[]

0

[ "PUB00070220", "PUB00070221" ]

[ "12915550", "18985015" ]

[ "Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein.", "Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities." ]

[ 2003, 2008 ]

2

[]

0

null

[ "Rhadinovirus" ]

[ 66 ]

1

[]

0

true

Family

Herpesvirus Latent membrane 2

Herpes_LAMP2

3

IPR009305

9,305

2-hydroxy-palmitic acid dioxygenase Mpo1-like

Mpo1-like

Family

13,097

false

Budding yeast Mpo1 is a dioxygenase that catalyzes the alpha-oxidation of a 2-hydroxy fatty acid in an Fe2+-dependent manner [ ]. This entry also includes Mpo1 homologues from bacteria, fungi and plants. Their function is not clear.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06127", "PTHR28026" ]

[ "Mpo1-like", "" ]

[ 13007, 7896 ]

2

[]

0

[]

0

[ "PUB00093982" ]

[ "30530523" ]

[ "Yeast Mpo1 Is a Novel Dioxygenase That Catalyzes the α-Oxidation of a 2-Hydroxy Fatty Acid in an Fe2+-Dependent Manner." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 8807, 4221, 2, 67 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 9, 1, 14, 1, 1, 13 ]

6

true

Family

2-hydroxy-palmitic acid dioxygenase Mpo1-like

Mpo1-like

8

IPR009307

9,307

Bacterial microcompartment shell protein EutS/PduU/CutR

EutS/PduU/CutR

Family

2,555

false

Bacterial microcompartments (BCMs) function as organelles by sequestering particular metabolic processes within the cell. The shells of varied microcompartments are built primarily from small proteins belonging to the BMC domain family. This family represents Bacterial microcompartment shell protein EutS, PduU and CutR...

[ "GO:0031469" ]

[ "bacterial microcompartment" ]

[ "cellular_component" ]

1

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF012296", "PTHR40449", "cd07046" ]

[ "EutS_PduU", "", "BMC_PduU-EutS" ]

[ 2362, 2555, 2167 ]

3

[]

0

[ "3cgi", "3i96", "3ia0", "4axi", "6xph", "6xpi", "6xpj", "6xpk", "6xpl" ]

9

[ "PUB00009955", "PUB00015066", "PUB00050993", "PUB00061435", "PUB00100314" ]

[ "10464203", "12923081", "18786396", "20044574", "32885887" ]

[ "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "Protein content of polyhedral organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol in Salmonella enterica serovar Typhimurium LT2.", "Structure of the PduU shell pro...

[ 1999, 2003, 2008, 2010, 2020 ]

5

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2541, 14 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bacterial microcompartment shell protein EutS/PduU/CutR

EutS/PduU/CutR

1

IPR009308

9,308

Rhamnose isomerase

Rhamnose_isomerase

Family

3,712

false

This family consists of several bacterial L-rhamnose isomerase proteins ( ). This enzyme interconverts L-rhamnose and L-rhamnulose. In some species, including Escherichia coli, this is the first step in rhamnose catabolism. Sequential steps are catalysed by rhamnulose kinase (rhaB), then rhamnulose-1-phosphate aldolase...

[ "GO:0008740", "GO:0030145" ]

[ "L-rhamnose isomerase activity", "manganese ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM", "PFAM", "NCBIFAM" ]

[ "MF_00541", "NF002203", "PF06134", "TIGR01748" ]

[ "RhaA", "PRK01076.1", "RhaA", "rhaA" ]

[ 2980, 2959, 3712, 2641 ]

4

[ "EC", "GP" ]

[ "5.3.1.14", "GenProp0457" ]

[ "EC:5.3.1.14", "GP:GenProp0457" ]

2

[ "1d8w", "1de5", "1de6", "3p14", "3uu0", "3uva", "3uxi", "8jq3", "8jq4", "8jq5", "8jq6" ]

11

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3646, 3, 63 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Rhamnose isomerase

Rhamnose_isomerase

1

IPR009309

9,309

IreB regulatory phosphoprotein-like

IreB-like

Family

4,245

false

This protein family represents a group of sequences from firmicutes, including IreB from Enterococcus faecalis and ReoM from Listeria monocytogenes. IreB is a cytosolic 10.5kDa protein that is highly conserved among low-GC Gram-positive bacteria. It is involved in the PASTA kinase-mediated signalling pathway regulating...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_01507", "NF003997", "PF06135", "PIRSF037258", "PTHR40067" ]

[ "UPF0297", "PRK05473.1", "IreB", "DUF965_bac", "" ]

[ 3637, 4200, 4245, 3887, 4237 ]

5

[]

0

[ "5us5", "6tif", "7y86", "7y8z" ]

4

[ "PUB00091063", "PUB00104135", "PUB00104198", "PUB00163191", "PUB00163192", "PUB00163193", "PUB00163194" ]

[ "28551334", "32469310", "24080657", "34624065", "37688380", "34672600", "40272164" ]

[ "Structure and Dimerization of IreB, a Negative Regulator of Cephalosporin Resistance in Enterococcus faecalis.", "PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM.", "IreB, a Ser/Thr kinase substrate, influences antimicrobial resistance in Enterococcus faecalis.", "PASTA...

[ 2017, 2020, 2013, 2021, 2023, 2021, 2025 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4218, 2, 25 ]

3

[]

0

true

Family

IreB regulatory phosphoprotein-like

IreB-like

3

IPR009311

9,311

Interferon alpha-inducible protein IFI6/IFI27-like

IFI6/IFI27-like

Family

5,805

false

This entry represents interferon alpha-inducible proteins IFI6 (also known as IFI-6-16) and IFI27-like (also known as ISG12) which play a role in the apoptotic process and also have pro-apoptotic activity [ , ]. ISG12a is a mitochondrial protein that contributes to IFN-induced apoptosis through perturbation of normal m...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06140", "PTHR16932" ]

[ "Ifi-6-16", "" ]

[ 5609, 4500 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9909505", "R-HSA-909733", "R-HSA-9909505" ]

[ "REACTOME:R-BTA-9909505", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9909505" ]

3

[ "2loq" ]

1

[ "PUB00068042", "PUB00070160", "PUB00095286" ]

[ "18330707", "14728724", "27673746" ]

[ "Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a.", "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.", "Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 prot...

[ 2008, 2004, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 5800 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 11, 15, 10, 7, 8 ]

5

true

Family

Interferon alpha-inducible protein IFI6/IFI27-like

IFI6/IFI27-like

8

IPR009312

9,312

Minor tail protein U-like

Phage_lambda_GpU-like

Family

1,154

false

This entry represents bacteriophage lambda, GpU, a minor tail protein. GpU plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the completion protein [ ]. GpU forms a hexameric ring within the tail structur...

[]

0

[ "PFAM" ]

[ "PF06141" ]

[ "Phage_tail_U" ]

[ 1154 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "1z1z", "3fz2", "3fzb", "8iyd", "8k37", "8xow", "8xpm", "8xqb" ]

8

[ "PUB00074548" ]

[ "2150582" ]

[ "Mechanism of length determination in bacteriophage lambda tails." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Viruses" ]

[ 1129, 25 ]

2

[]

0

true

Family

Minor tail protein U-like

Phage_lambda_GpU-like

2

IPR009313

9,313

Baculovirus 11kDa

Baculo_11_kDa

Family

103

false

This is a family of uncharacterised Baculovirus proteins that are all about 11kDa in size.

[]

0

[ "PFAM" ]

[ "PF06143" ]

[ "Baculo_11_kDa" ]

[ 103 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae", "Metabacillus idriensis" ]

[ 102, 1 ]

2

[]

0

true

Family

Baculovirus 11kDa

Baculo_11_kDa

9

IPR009314

9,314

Coronavirus nonstructural NS1

Corona_NS1

Family

58

false

One of the members of this family is a 4.9kDa proteins, encoded by Bovine coronavirus NS1 [ ].

[]

0

[ "PFAM" ]

[ "PF06145" ]

[ "Corona_NS1" ]

[ 58 ]

1

[ "GP" ]

[ "GenProp1009" ]

[ "GP:GenProp1009" ]

1

[]

0

[ "PUB00012272" ]

[ "2142556" ]

[ "Sequence and expression analysis of potential nonstructural proteins of 4.9, 4.8, 12.7, and 9.5 kDa encoded between the spike and membrane protein genes of the bovine coronavirus." ]

[ 1990 ]

1

[]

0

null

[ "Coronaviridae" ]

[ 58 ]

1

[]

0

true

Family

Coronavirus nonstructural NS1

Corona_NS1

3

IPR009315

9,315

Phosphate-starvation-induced PsiE

P_starv_induced_PsiE

Family

4,096

false

Phosphate-starvation-inducible E (PsiE) expression is under direct positive and negative control by PhoB and cAMP-CRP, respectively [ ]. PsiE is an integral membrane protein with four transmembrane helices. The second α helix contains a conserved glutamic acid residue and the third helix contains a conserved arginine r...

[ "GO:0016036", "GO:0016020" ]

[ "cellular response to phosphate starvation", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_01048", "PIRSF029598", "PTHR37819" ]

[ "PsiE", "PsiE", "" ]

[ 1327, 3482, 4096 ]

3

[]

0

[]

0

[ "PUB00012273" ]

[ "10986267" ]

[ "Dual transcriptional regulation of the Escherichia coli phosphate-starvation-inducible psiE gene of the phosphate regulon by PhoB and the cyclic AMP (cAMP)-cAMP receptor protein complex." ]

[ 2000 ]

1

[ "IPR020948" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4076, 3, 17 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphate-starvation-induced PsiE

P_starv_induced_PsiE

9

IPR009316

9,316

COG complex component, COG2

COG2

Family

5,091

false

The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function and it is necessary for retrograde trafficking in the Golgi apparatus and for protein glycosylation [ , ].

[ "GO:0007030", "GO:0015031", "GO:0016020" ]

[ "Golgi organization", "protein transport", "membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR12961" ]

[ "" ]

[ 5091 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6807878", "R-CEL-6811438", "R-DDI-6807878", "R-DDI-6811438", "R-DME-6807878", "R-DME-6811438", "R-DME-6811440", "R-HSA-6807878", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-6807878", "R-MMU-6811438", "R-MMU-6811440" ]

[ "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811438", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811438", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811438", "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6807878", "REACTOM...

13

[]

0

[ "PUB00012274", "PUB00100047" ]

[ "11980916", "34061181" ]

[ "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.", "Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System." ]

[ 2002, 2021 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5091 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 3, 1, 1, 1, 6, 5, 1, 2, 4, 1, 22 ]

11

true

Family

COG complex component, COG2

COG2

6

IPR009317

9,317

ChaB

Family

3,768

false

This family of proteins contain a conserved 60 residue region. This protein is known as ChaB in Escherichia coli and is found next to ChaA, which is a cation transporter protein [ , ]. ChaB may regulate ChaA function in some way.

[]

0

[ "PFAM" ]

[ "PF06150" ]

[ "ChaB" ]

[ 3768 ]

1

[]

0

[ "1sg7" ]

1

[ "PUB00019288", "PUB00031047" ]

[ "12460671", "15306028" ]

[ "Expression of chaA, a sodium ion extrusion system of Escherichia coli, is regulated by osmolarity and pH.", "The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 58, 3420, 10, 245, 35 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ChaB

5

IPR009318

9,318

Gustatory receptor

Gustatory_rcpt

Family

2,340

false

In Drosophila, taste is perceived by gustatory neurons located in sensilla distributed on several different appendages throughout the body of the animal. This family represents the taste receptor sensitive to trehalose [ , ].

[ "GO:0008527", "GO:0050912", "GO:0016020" ]

[ "taste receptor activity", "detection of chemical stimulus involved in sensory perception of taste", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF06151", "PIRSF038981" ]

[ "Trehalose_recp", "GRP" ]

[ 2340, 875 ]

2

[]

0

[ "8jme", "8jmh", "8jmi", "8ze0", "8ze2" ]

5

[ "PUB00013409", "PUB00013410" ]

[ "10710312", "11516643" ]

[ "Candidate taste receptors in Drosophila.", "Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Eumetazoa", "viral metagenome" ]

[ 2339, 1 ]

2

[ "Drosophila melanogaster" ]

[ 62 ]

1

true

Family

Gustatory receptor

Gustatory_rcpt

8

IPR009319

9,319

Lactococcus phage , Structural protein

Phage_A118_VSP1

Family

1,770

false

This entry represents Structural protein from Lactococcus phage and similar proteins from tailed bacteriophages and bacterial prophages.

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06152" ]

[ "Phage_min_cap2" ]

[ 1770 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2, 1505, 3, 248, 12 ]

5

[]

0

true

Family

Lactococcus phage , Structural protein

Phage_A118_VSP1

4

IPR009320

9,320

Antitoxin CbeA

Antitoxin_CbeA

Family

1,837

false

This is a family of cognate antitoxins to the CbtA toxins that act by inhibiting the polymerisation of cytoskeletal proteins (see ). These are classified as a type IV toxin-antitoxin system [ ]. The family includes three proteins from E. coli YagB, YeeU and YfjZ, which act not by forming a complex with CbtA but through...

[ "GO:0051495" ]

[ "positive regulation of cytoskeleton organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06154" ]

[ "CbeA_antitoxin" ]

[ 1837 ]

1

[]

0

[ "2ea9", "2h28", "2inw", "2jn7" ]

4

[ "PUB00086029", "PUB00086030" ]

[ "14594833", "22515815" ]

[ "A novel family of Escherichia coli toxin-antitoxin gene pairs.", "YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli." ]

[ 2003, 2012 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1835, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Family

Antitoxin CbeA

Antitoxin_CbeA

4

IPR009323

9,323

Protein of unknown function DUF979

DUF979

Family

3,456

false

This family consists of several putative bacterial membrane proteins. The function of this family is unclear.

[]

0

[ "PFAM" ]

[ "PF06166" ]

[ "DUF979" ]

[ 3456 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Linnemannia gamsii", "Thermococcus aggregans", "metagenomes" ]

[ 3441, 1, 1, 13 ]

4

[]

0

true

Family

Protein of unknown function DUF979

DUF979

3

IPR009324

9,324

Protein of unknown function DUF981

DUF981

Family

530

false

This is a family of uncharacterised proteins found in bacteria and archaea.

[]

0

[ "PFAM" ]

[ "PF06168" ]

[ "DUF981" ]

[ 530 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 125, 391, 14 ]

3

[]

0

true

Family

Protein of unknown function DUF981

DUF981

7

IPR009325

9,325

Protein of unknown function DUF983

DUF983

Family

7,292

false

This family consists of several bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06170" ]

[ "DUF983" ]

[ 7292 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7220, 5, 67 ]

3

[]

0

true

Family

Protein of unknown function DUF983

DUF983

4

IPR009326

9,326

Protein of unknown function DUF984

DUF984

Family

6,242

false

This is a family of bacterial proteins with unknown function. This entry includes the uncharacterised protein YhfF from Bacillus subtilis.

[]

0

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF021320", "PTHR39203", "cd06553" ]

[ "DUF984", "", "ASCH_Ef3133_like" ]

[ 4976, 6213, 4948 ]

3

[]

0

[ "1t62", "3s9x" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 5, 6116, 83, 38 ]

4

[]

0

true

Family

Protein of unknown function DUF984

DUF984

1

IPR009328

9,328

Protein of unknown function DUF986

DUF986

Family

1,639

false

This family consists of several bacterial putative membrane proteins of unknown function.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_01071", "NF002791", "PF06173", "PIRSF020687" ]

[ "UPF0266", "PRK02913.1", "DUF986", "UCP020687" ]

[ 1541, 1550, 1639, 1516 ]

4

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanocaldococcus jannaschii", "metagenomes" ]

[ 1634, 2, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF986

DUF986

9

IPR009329

9,329

Protein of unknown function DUF987

DUF987

Family

959

false

This is a family of bacterial proteins that are related to the hypothetical protein YeeT.

[]

0

[ "PFAM" ]

[ "PF06174" ]

[ "DUF987" ]

[ 959 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Pseudomonadati", "human gut metagenome" ]

[ 18, 938, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Protein of unknown function DUF987

DUF987

8

IPR009330

9,330

Lipopolysaccharide core heptose(II) kinase

LipoPS_heptP_kinase

Family

1,624

false

This family consists of several bacterial lipopolysaccharide core biosynthesis proteins (WaaY or RfaY). The waaY, waaQ, and waaP genes are located in the central operon of the waa (formerly rfa) locus on the chromosome of Escherichia coli. This locus contains genes whose products are involved in the assembly of the cor...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007684", "PF06176" ]

[ "PRK10359.1", "WaaY" ]

[ 1144, 1624 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "GenProp0203", "GenProp1651", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PW...

[ "EC:2.7.1.-", "GP:GenProp0203", "GP:GenProp1651", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948"...

23

[]

0

[ "PUB00012277" ]

[ "9756860" ]

[ "Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Candidatus Marsarchaeota", "Eukaryota", "Pithoviruses", "metagenomes" ]

[ 1502, 6, 109, 5, 2 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipopolysaccharide core heptose(II) kinase

LipoPS_heptP_kinase

8

IPR009331

9,331

Oligogalacturonate-specific porin

Oligogalacturonate-sp_porin

Family

4,136

false

This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM ( ) from Erwinia chrysanthemi. The phytopathogenic Gram-negative bacteria E. chrysanthemi secretes pectinases, which are able to degrade the pectic polymers of plant cell walls, and uses the deg...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06178", "PTHR38105" ]

[ "KdgM", "" ]

[ 4125, 3975 ]

2

[]

0

[ "2wjq", "2wjr", "4fqe", "4pr7", "8xua" ]

5

[ "PUB00012278" ]

[ "11773048" ]

[ "The oligogalacturonate-specific porin KdgM of Erwinia chrysanthemi belongs to a new porin family." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Salmonella phage JD01", "Thelohanellus kitauei", "human gut metagenome" ]

[ 4129, 1, 1, 5 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Oligogalacturonate-specific porin

Oligogalacturonate-sp_porin

9

IPR009332

9,332

Mediator of RNA polymerase II transcription subunit 22

Med22

Family

3,968

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06179", "PTHR12434" ]

[ "Med22", "" ]

[ 3946, 2814 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-381340", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110" ]

3

[ "3j1o", "3r84", "3rj1", "4gwp", "4gwq", "4h63", "4v1o", "5n9j", "5oqm", "5sva", "5u0p", "5u0s", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw"...

33

[ "PUB00012279" ]

[ "11891058" ]

[ "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts." ]

[ 2002 ]

1

[]

[ "IPR016530" ]

0

1

0

[ "Eukaryota" ]

[ 3968 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 4, 2, 6, 2, 1, 5, 3, 1, 1, 5 ]

12

true

Family

Mediator of RNA polymerase II transcription subunit 22

Med22

3

IPR009333

9,333

Protein of unknown function DUF992

DUF992

Family

1,614

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06186" ]

[ "DUF992" ]

[ 1614 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 1606, 8 ]

2

[]

0

true

Family

Protein of unknown function DUF992

DUF992

9

IPR009334

9,334

Protein of unknown function DUF993

DUF993

Family

3,511

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06187" ]

[ "DUF993" ]

[ 3511 ]

1

[]

0

[ "4dnh" ]

1

[]

0

[]

0

null

[ "Bacteria", "Ricinus communis", "metagenomes" ]

[ 3493, 2, 16 ]

3

[]

0

true

Family

Protein of unknown function DUF993

DUF993

3

IPR009337

9,337

Protein of unknown function DUF995

DUF995

Family

667

false

This is a family of uncharacterised Proteobacteria proteins.

[]

0

[ "PFAM" ]

[ "PF06191" ]

[ "DUF995" ]

[ 667 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 661, 3, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF995

DUF995

9

IPR009338

9,338

Protein of unknown function Orf51

Orf51

Family

237

false

This entry is represents a family of predicted proteins found in bacteriophages and prophages.

[]

0

[ "PFAM" ]

[ "PF06194" ]

[ "Phage_Orf51" ]

[ 237 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 125, 112 ]

2

[]

0

true

Family

Protein of unknown function Orf51

Orf51

2

IPR009339

9,339

Protein of unknown function DUF998

DUF998

Family

9,529

false

This is a family of proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF06197" ]

[ "DUF998" ]

[ 9529 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 640, 8763, 29, 97 ]

4

[]

0

true

Family

Protein of unknown function DUF998

DUF998

8

IPR009340

9,340

Protein of unknown function DUF999

DUF999

Family

22

false

This is a family of conserved Schizosaccharomyces proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF06198" ]

[ "DUF999" ]

[ 22 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Schizosaccharomyces" ]

[ 22 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 10 ]

1

true

Family

Protein of unknown function DUF999

DUF999

4

IPR009343

9,343

Protein of unknown function DUF1002

DUF1002

Family

3,189

false

This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.

[]

0

[ "PFAM" ]

[ "PF06207" ]

[ "DUF1002" ]

[ 3189 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomada group", "metagenomes" ]

[ 3134, 46, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF1002

DUF1002

5

IPR009344

9,344

Borna disease virus G

BDV_G

Family

116

false

This family consists of Borna disease virus G glycoprotein sequences. Borna disease virus (BDV) infection produces a variety of clinical diseases, from behavioural illnesses to classical fatal encephalitis [ ]. G protein is important for viral entry into the host cell [ , ].

[]

0

[ "PFAM" ]

[ "PF06208" ]

[ "BDV_G" ]

[ 116 ]

1

[]

0

[]

0

[ "PUB00012286", "PUB00013406", "PUB00013407" ]

[ "12163584", "8985354", "11435588" ]

[ "Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes.", "Biochemical and functional analysis of the Borna disease virus G protein.", "N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recogn...

[ 2002, 1997, 2001 ]

3

[]

0

null

[ "Mononegavirales" ]

[ 116 ]

1

[]

0

true

Family

Borna disease virus G

BDV_G

9

IPR009345

9,345

BMP and activin membrane-bound inhibitor

BAMBI

Family

899

false

This entry consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related t...

[ "GO:0030512", "GO:0090263" ]

[ "negative regulation of transforming growth factor beta receptor signaling pathway", "positive regulation of canonical Wnt signaling pathway" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037456" ]

[ "BAMBI" ]

[ 899 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2173788", "R-MMU-2173788", "R-RNO-2173788" ]

[ "REACTOME:R-HSA-2173788", "REACTOME:R-MMU-2173788", "REACTOME:R-RNO-2173788" ]

3

[]

0

[ "PUB00012288", "PUB00077059", "PUB00099036", "PUB00099037", "PUB00099038", "PUB00099039" ]

[ "10519551", "26247931", "32740798", "31786181", "30580997", "32739209" ]

[ "Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.", "BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling.", "The role of BAMBI in regulating adipogenesis and myogenesis and the association between its polymorphisms and growth traits in cattle.", "Bone morphogenetic ...

[ 1999, 2015, 2020, 2020, 2019, 2020 ]

6

[]

0

null

[ "Chordata" ]

[ 899 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 2, 3 ]

4

true

Family

BMP and activin membrane-bound inhibitor

BAMBI

7

IPR009346

9,346

GRIM-19

Family

3,914

false

This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homologue of GRIM-19 was co-purified w...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06212", "PTHR12966" ]

[ "GRIM-19", "" ]

[ 3908, 3792 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-9837999" ]

11

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9b", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs"...

283

[ "PUB00012289" ]

[ "12628925" ]

[ "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3914 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 1, 1, 7, 1, 1, 2, 5, 7 ]

10

true

Family

GRIM-19

5