LiteFold/InterPro · Datasets at Hugging Face

IPR009837

9,837

Matrix extracellular phosphoglycoprotein

MEPE

Family

552

false

Matrix extracellular phosphoglycoprotein (also known as Osteoblast/osteocyte factor 45 or osteoregulin) has multiple functions, being involved in cell signalling, mineral homeostasis, and mineralization, as it plays a role in bone mineralization by osteoblasts and cartilage mineralization by chondrocytes [ , , ]. It pr...

[ "GO:0031214" ]

[ "biomineral tissue development" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07175", "PTHR16510" ]

[ "Osteoregulin", "" ]

[ 325, 551 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-381426", "R-GGA-8957275", "R-HSA-381426", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275", "R-RNO-381426", "R-RNO-8957275" ]

[ "REACTOME:R-GGA-381426", "REACTOME:R-GGA-8957275", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

8

[]

0

[ "PUB00013029", "PUB00095364", "PUB00095366", "PUB00095367", "PUB00095368", "PUB00095369" ]

[ "10967096", "19998030", "19005008", "14962809", "20665709", "22766095" ]

[ "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes.", "MEPE's diverse effects on mineralization.", "Matrix extracellular phosphoglycoprotein inhibits phosphate transport.", "MEPE has the prope...

[ 2000, 2010, 2008, 2004, 2010, 2012 ]

6

[]

0

null

[ "Amniota", "Paenibacillus antibioticophila" ]

[ 551, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 5 ]

3

true

Family

Matrix extracellular phosphoglycoprotein

MEPE

2

IPR009838

9,838

Type IV conjugative transfer system, protein TraL

T4SS_TraL

Family

2,198

false

This entry represents bacterial TraL proteins. TraL is a predicted peripheral membrane protein involved in bacterial sex pilus assembly [ ]. TraL is part of the type IV secretion system for conjugative plasmid transfer [ ]. The exact function of TraL is unknown.

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF07178", "TIGR02762" ]

[ "TraL", "TraL_TIGR" ]

[ 2182, 1809 ]

2

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[]

0

[ "PUB00012609", "PUB00034396" ]

[ "8655498", "16138100" ]

[ "Analysis of the traLEKBP sequence and the TraP protein from three F-like plasmids: F, R100-1 and ColB2.", "Mobile genetic elements: the agents of open source evolution." ]

[ 1996, 2005 ]

2

[]

[ "IPR016382" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2183, 6, 9 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type IV conjugative transfer system, protein TraL

T4SS_TraL

7

IPR009839

9,839

SseB, N-terminal domain

SseB_N

Domain

11,524

false

This entry represents the N-terminal domain of SseB. SseB appears to be found exclusively in Enterobacteria. SseB enhances serine-sensitivity in Escherichia coli [ ] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [ ].

[]

0

[ "PFAM" ]

[ "PF07179" ]

[ "SseB" ]

[ 11524 ]

1

[]

0

[]

0

[ "PUB00013031", "PUB00013032" ]

[ "7982894", "12724372" ]

[ "Enhancement of serine-sensitivity by a gene encoding rhodanese-like protein in Escherichia coli.", "SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system." ]

[ 1994, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobrevibacter", "Siphoviridae sp. ctTwu10", "metagenomes" ]

[ 11407, 14, 29, 1, 73 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

SseB, N-terminal domain

SseB_N

7

IPR009841

9,841

VirC2

Family

90

false

This family consists of several VirC2 proteins which seem to be found exclusively in Agrobacterium species and Rhizobium etli. VirC2 is known to be involved in virulence in Agrobacterium species but its exact function is unclear [ , ].

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF010436", "PF07181", "PIRSF016094" ]

[ "PRK13862.1", "VirC2", "VirC2" ]

[ 60, 90, 66 ]

3

[]

0

[ "2rh3" ]

1

[ "PUB00013447", "PUB00013448" ]

[ "3584058", "3759904" ]

[ "Molecular characterization of the virC genes of the Ti plasmid.", "Molecular characterization of a host-range-determining locus from Agrobacterium tumefaciens." ]

[ 1987, 1986 ]

2

[]

0

null

[ "Alphaproteobacteria" ]

[ 90 ]

1

[]

0

true

Family

VirC2

7

IPR009842

9,842

Protein of unknown function DUF1402

DUF1402

Family

666

false

This family consists of several hypothetical bacterial proteins of around 310 residues in length. Members of this family seem to be found exclusively in alphaproteobacteria. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07182" ]

[ "DUF1402" ]

[ 666 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 666 ]

1

[]

0

true

Family

Protein of unknown function DUF1402

DUF1402

6

IPR009843

9,843

Protein of unknown function DUF1403

DUF1403

Family

892

false

This family consists of several hypothetical bacterial proteins of around 320 residues in length. Members of this family are mainly found in Rhizobium and Agrobacterium species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07183" ]

[ "DUF1403" ]

[ 892 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pleodorina starrii", "Pseudomonadota", "marine sediment metagenome" ]

[ 3, 879, 10 ]

3

[]

0

true

Family

Protein of unknown function DUF1403

DUF1403

6

IPR009845

9,845

Protein of unknown function DUF1405

DUF1405

Family

2,408

false

This family consists of several bacterial and related archaeal protein of around 180 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07187", "PTHR40042" ]

[ "DUF1405", "" ]

[ 2406, 2334 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Phytophthora kernoviae 00238/432", "human gut metagenome" ]

[ 572, 1834, 1, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1405

DUF1405

8

IPR009846

9,846

Splicing factor 3B subunit 5/RDS3 complex subunit 10

SF3b5/RDS3-10

Family

3,744

false

This family consists of several eukaryotic splicing factor 3B subunit 5 (SF3b5) proteins. SF3b5 is a 10kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex. SF3b5 and SF3b14b are also thought to facilitate the i...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07189", "PTHR20978" ]

[ "SF3b10", "" ]

[ 3743, 3595 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-BTA-72165", "R-DME-72165", "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-DME-72165", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165" ]

7

[ "5gm6", "5hy7", "5ife", "5lqw", "5nrl", "5o9z", "5z56", "5z57", "5z58", "5zwm", "5zwo", "5zya", "6ah0", "6ahd", "6en4", "6ff4", "6ff7", "6g90", "6qx9", "6y50", "6y5q", "7abg", "7abh", "7abi", "7b0i", "7b91", "7b92", "7b9c", "7dco", "7dvq", "7evn", "7evo"...

70

[ "PUB00013034", "PUB00042559" ]

[ "12234937", "15565172" ]

[ "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.", "Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing." ]

[ 2002, 2004 ]

2

[]

[ "IPR017089" ]

0

1

0

[ "Eukaryota" ]

[ 3744 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 8, 1, 3, 1, 2, 1, 5, 2, 1, 1, 6 ]

11

true

Family

Splicing factor 3B subunit 5/RDS3 complex subunit 10

SF3b5/RDS3-10

6

IPR009847

9,847

SNURF family

SNURF

Family

267

false

This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested that SNURF is involved in the regulation of processes required for late steps of spermatid maturation [ , ...

[]

0

[ "PFAM" ]

[ "PF07192" ]

[ "SNURF" ]

[ 267 ]

1

[]

0

[]

0

[ "PUB00013449", "PUB00013450" ]

[ "12351196", "12874792" ]

[ "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation.", "Translational regulation of a novel testis-specific RNF4 transcript." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Eutheria" ]

[ 267 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 2 ]

3

true

Family

SNURF family

SNURF

9

IPR009848

9,848

Protein of unknown function DUF1408

DUF1408

Family

45

false

This family consists of several hypothetical Lactococcus lactis and related phage proteins of around 75 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07193" ]

[ "DUF1408" ]

[ 45 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Lactococcus" ]

[ 10, 35 ]

2

[]

0

true

Family

Protein of unknown function DUF1408

DUF1408

6

IPR009849

9,849

Domain of unknown function DUF1410

DUF1410

Domain

168

false

This entry represents a conserved domain, approximately 100 residues long, multiple copies of which are sometimes found within hypothetical proteins of unknown function from Mycoplasmoidales.

[]

0

[ "PFAM" ]

[ "PF07198" ]

[ "DUF1410" ]

[ 168 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 168 ]

1

[]

0

true

Domain

Domain of unknown function DUF1410

DUF1410

1

IPR009850

9,850

Domain of unknown function DUF1411

DUF1411

Domain

41

false

This domain is sometimes repeated within some eukaryotic Babesia proteins of unknown function, including from B.bovis. It covers almost the full length of the protein in sequences from the archaeal Sulfolobus, such as .

[]

0

[ "PFAM" ]

[ "PF07199" ]

[ "DUF1411" ]

[ 41 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Babesia", "Bacillus cereus group", "Saccharolobus" ]

[ 28, 2, 11 ]

3

[]

0

true

Domain

Domain of unknown function DUF1411

DUF1411

9

IPR009851

9,851

Modifier of rudimentary, Modr

Mod_r

Domain

8,122

false

This entry represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic [ ], and both of these regions...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF07200", "PS51314" ]

[ "Mod_r", "VPS37_C" ]

[ 7986, 7540 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-917729", "R-HSA-162588", "R-HSA-174490", "R-HSA-917729", "R-HSA-9610379", "R-HSA-9615710", "R-MMU-917729", "R-SCE-917729" ]

[ "REACTOME:R-DDI-917729", "REACTOME:R-HSA-162588", "REACTOME:R-HSA-174490", "REACTOME:R-HSA-917729", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9615710", "REACTOME:R-MMU-917729", "REACTOME:R-SCE-917729" ]

8

[ "2caz", "2f66", "2p22", "4gdo", "6vme" ]

5

[ "PUB00013037" ]

[ "7651329" ]

[ "Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 18, 8103, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 6, 4, 11, 6, 1, 8, 17, 1, 15 ]

11

true

Domain

Modifier of rudimentary, Modr

Mod_r

6

IPR009852

9,852

Centromere protein J, C-terminal domain

CENPJ_C_dom

Domain

2,546

false

This entry represents a C-terminal domain found in members of the T complex protein 10 family. This domain contains unusual G repeats [ ]. Centromere protein J (also known as Centrosomal-P4.1-associated-protein, CPAP), a member of the TCP10 family, plays an important role in cell division and centrosome function by par...

[]

0

[ "PFAM" ]

[ "PF07202" ]

[ "Tcp10_C" ]

[ 2546 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-6804115", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-6804115", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-6804115", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MM...

16

[ "4bxp", "4bxq", "4bxr", "4by2", "4ld1", "4ld3", "4lzf", "4mpz" ]

8

[ "PUB00013039", "PUB00033370", "PUB00033371", "PUB00052372", "PUB00060686", "PUB00101591", "PUB00101592", "PUB00101593", "PUB00101594", "PUB00101595" ]

[ "12068715", "15047868", "11003675", "17681131", "20531387", "22699936", "24052813", "24076405", "24385583", "27306797" ]

[ "[Sterility of males determined by functional features of the mouse spermatozoa bearing t-complex]", "Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly.", "Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) whi...

[ 2002, 2004, 2000, 2007, 2010, 2012, 2013, 2013, 2014, 2016 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 36, 2507, 3 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 1, 3, 23, 12 ]

5

true

Domain

Centromere protein J, C-terminal domain

CENPJ_C_dom

3

IPR009853

9,853

Protein of unknown function DUF1412

DUF1412

Family

96

false

This family consists of several Caenorhabditis elegans proteins of around 70-75 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07203", "PTHR34602" ]

[ "DUF1412", "" ]

[ 96, 92 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 96 ]

1

[ "Caenorhabditis elegans" ]

[ 9 ]

1

true

Family

Protein of unknown function DUF1412

DUF1412

8

IPR009854

9,854

Orthoreovirus membrane fusion p10

Orthoreo_P10

Family

109

false

This family consists of several Orthoreovirus membrane fusion protein p10 sequences. p10 is thought to be a multifunctional protein that plays a key role in virus-host interaction [ ].

[]

0

[ "PFAM" ]

[ "PF07204" ]

[ "Orthoreo_P10" ]

[ 109 ]

1

[]

0

[]

0

[ "PUB00013040" ]

[ "11893756" ]

[ "Modification of late membrane permeability in avian reovirus-infected cells: viroporin activity of the S1-encoded nonstructural p10 protein." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Orthornavirae" ]

[ 19, 90 ]

2

[]

0

true

Family

Orthoreovirus membrane fusion p10

Orthoreo_P10

6

IPR009855

9,855

Baculovirus late expression factor 10

Baculo_LEF-10

Family

105

false

This family consists of several Baculovirus specific late expression factor 10 (LEF-10) sequences. LEF-10 is thought to be a late expressed structural protein although its exact function is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF07206" ]

[ "Baculo_LEF-10" ]

[ 105 ]

1

[]

0

[]

0

[ "PUB00013041" ]

[ "12202224" ]

[ "Transcriptional analysis and preliminary characterization of ORF Bm42 from Bombyx mori nucleopolyhedrovirus." ]

[ 2002 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 105 ]

1

[]

0

true

Family

Baculovirus late expression factor 10

Baculo_LEF-10

6

IPR009856

9,856

Light regulated Lir1

Lir1

Family

664

false

This family consists of several plant specific light regulated Lir1 proteins. Lir1 mRNA accumulates in the light, reaching maximum and minimum steady-state levels at the end of the light and dark period, respectively. Plants germinated in the dark have very low levels of lir1 mRNA, whereas plants germinated in continuo...

[ "GO:0009507" ]

[ "chloroplast" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07207", "PTHR36762" ]

[ "Lir1", "" ]

[ 664, 623 ]

2

[]

0

[]

0

[ "PUB00013042", "PUB00087327" ]

[ "8499615", "26941088" ]

[ "Circadian rhythmicity in the expression of a novel light-regulated rice gene.", "LIGHT-INDUCED RICE1 Regulates Light-Dependent Attachment of LEAF-TYPE FERREDOXIN-NADP+ OXIDOREDUCTASE to the Thylakoid Membrane in Rice and Arabidopsis." ]

[ 1993, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 664 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 16 ]

3

true

Family

Light regulated Lir1

Lir1

5

IPR009857

9,857

Uncharacterised protein family UPF0352

UPF0352

Family

1,932

false

This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.

[]

0

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00816", "PF07208", "PIRSF006188" ]

[ "UPF0352", "DUF1414", "UCP006188" ]

[ 1806, 1932, 1824 ]

3

[]

0

[ "2jpq", "2jr2", "2jrx", "2juw", "2juz", "2ota", "2qti" ]

7

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 1930, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0352

UPF0352

1

IPR009858

9,858

Protein of unknown function DUF1415

DUF1415

Family

3,593

false

This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07209" ]

[ "DUF1415" ]

[ 3593 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3141, 412, 40 ]

3

[]

0

true

Family

Protein of unknown function DUF1415

DUF1415

4

IPR009859

9,859

Protein of unknown function, Gam-like

Gam-like

Family

77

false

The Gam protein, originally characterised in Bacteriophage Mu, protects linear double stranded DNA from exonuclease degradation in vitro and in vivo [ ]. This protein is also found in many bacterial species as part of a suspected prophage. Further studies have shown that Gam is a functional counterpart of the eukaryoti...

[]

0

[ "PIRSF" ]

[ "PIRSF015195" ]

[ "DUF1417" ]

[ 77 ]

1

[]

0

[]

0

[ "PUB00013109", "PUB00014993" ]

[ "2945162", "12524520" ]

[ "Purification of the gam gene-product of bacteriophage Mu and determination of the nucleotide sequence of the gam gene.", "The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku." ]

[ 1986, 2003 ]

2

[ "IPR009951" ]

[]

1

0

1

[ "Bacilli", "Caudoviricetes" ]

[ 63, 14 ]

2

[]

0

true

Family

Protein of unknown function, Gam-like

Gam-like

5

IPR009860

9,860

Hyaluronidase, bacterial

Hyaluronidase_bac

Family

73

false

This family consists of several phage associated hyaluronidase proteins ( ) which are mostly from Streptococcus pyogenes and its bacteriophages. The substrate of hyaluronidase is hyaluronic acid, a sugar polymer composed of alternating N-acetylglucosamine and glucuronic acid residues. Hyaluronic acid is found in the gr...

[ "GO:0004415", "GO:0045227" ]

[ "hyalurononglucosaminidase activity", "capsule polysaccharide biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07212" ]

[ "Hyaluronidase_1" ]

[ 73 ]

1

[]

0

[ "2c3f", "2dp5", "2wb3", "2wh7", "2yvv", "2yw0", "2yx2", "3eka", "4ufq", "6wv2", "6wwx", "6wxa", "6x3m" ]

13

[ "PUB00013043" ]

[ "7622224" ]

[ "Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "unclassified bacterial viruses" ]

[ 71, 2 ]

2

[]

0

true

Family

Hyaluronidase, bacterial

Hyaluronidase_bac

1

IPR009861

9,861

Hematopoietic cell signal transducer

HCST

Family

450

false

Hematopoietic cell signal transducer (HCST, also known as DAP10) is a transmembrane adaptor that associates with an activation receptor, NKG2D, which is found on NK and subsets of T cells. The ligands for this receptor include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins [ ]. In act...

[ "GO:0005102", "GO:0043548", "GO:0050776", "GO:0051897", "GO:0016020" ]

[ "signaling receptor binding", "phosphatidylinositol 3-kinase binding", "regulation of immune response", "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "PFAM", "PANTHER" ]

[ "PF07213", "PTHR21409" ]

[ "DAP10", "" ]

[ 445, 397 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-198933", "R-HSA-198933", "R-MMU-198933", "R-RNO-198933", "R-SSC-198933" ]

[ "REACTOME:R-BTA-198933", "REACTOME:R-HSA-198933", "REACTOME:R-MMU-198933", "REACTOME:R-RNO-198933", "REACTOME:R-SSC-198933" ]

5

[]

0

[ "PUB00013044", "PUB00075576" ]

[ "12740576", "18097042" ]

[ "NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.", "Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors." ]

[ 2003, 2008 ]

2

[]

0

null

[ "Eukaryota", "Legionella antarctica" ]

[ 449, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4 ]

4

true

Family

Hematopoietic cell signal transducer

HCST

7

IPR009862

9,862

Protein of unknown function DUF1419

DUF1419

Family

485

false

This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti (Mesorhizobium loti). The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07215" ]

[ "DUF1419" ]

[ 485 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chiloscyllium punctatum", "Pseudomonadati" ]

[ 2, 483 ]

2

[]

0

true

Family

Protein of unknown function DUF1419

DUF1419

5

IPR009863

9,863

Type III secretion protein, LcrG

T3SS_LcrG_PcrG

Family

130

false

LcrG is found in type III secretion operons, along with LcrR, H and V. LcrG is a negative regulator for secretion of Yersinia outer-membrane proteins (Yops) by blocking the secretion apparatus from the inner membrane [ , ]. Also known as PcrG in Pseudomonas, the protein is believed to make a 1:1 complex with PcrV (LcrV...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07216", "TIGR02573" ]

[ "LcrG", "LcrG_PcrG" ]

[ 130, 107 ]

2

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[]

0

[ "PUB00007789", "PUB00013046", "PUB00020747", "PUB00069640" ]

[ "11443094", "9484897", "14565848", "19109068" ]

[ "Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.", "Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus.", "Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginos...

[ 2001, 1998, 2003, 2009 ]

4

[]

0

null

[ "Bacteria", "Clupea harengus" ]

[ 127, 3 ]

2

[]

0

true

Family

Type III secretion protein, LcrG

T3SS_LcrG_PcrG

1

IPR009864

9,864

Rhoptry-associated protein 1, plasmodium

RAP1_Plasmodium

Family

260

false

This family consists of several rhoptry-associated protein 1 (RAP-1) sequences which appear to be specific to Plasmodium falciparum [ ].

[]

0

[ "PFAM" ]

[ "PF07218" ]

[ "RAP1" ]

[ 260 ]

1

[]

0

[]

0

[ "PUB00013048" ]

[ "11254620" ]

[ "Rhoptry-associated protein 1-binding monoclonal antibody raised against a heterologous peptide sequence inhibits Plasmodium falciparum growth in vitro." ]

[ 2001 ]

1

[]

0

null

[ "Alveolata" ]

[ 260 ]

1

[]

0

true

Family

Rhoptry-associated protein 1, plasmodium

RAP1_Plasmodium

2

IPR009865

9,865

Proacrosin binding sp32

Proacrosin-bd

Family

972

false

This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein, which is known to bind with 55- and 53kDa proacrosins and the 49kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin ma...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07222", "PTHR21362" ]

[ "PBP_sp32", "" ]

[ 955, 954 ]

2

[]

0

[]

0

[ "PUB00013050", "PUB00077124" ]

[ "8144514", "25867384" ]

[ "An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate.", "Expression and tyrosine phosphorylation of sp32 regulate the activation of the boar proacrosin/acrosin system." ]

[ 1994, 2015 ]

2

[]

0

null

[ "Eukaryota", "Mycobacterium bohemicum DSM 44277" ]

[ 971, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 4, 6 ]

3

true

Family

Proacrosin binding sp32

Proacrosin-bd

4

IPR009866

9,866

NADH:ubiquinone oxidoreductase, subunit NDUFB4

NADH_UbQ_OxRdtase_NDUFB4_su

Family

1,948

false

This family contains the accessory subunit of complex I NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4, not involved in catalysis [ ].

[ "GO:0005739" ]

[ "mitochondrion" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07225", "PTHR15469" ]

[ "NDUF_B4", "" ]

[ 1947, 1481 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

4

[ "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf", "6zkg"...

208

[ "PUB00005074", "PUB00043561", "PUB00045437", "PUB00097152" ]

[ "1470679", "10940377", "18394423", "31485716" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).", "Insights from Drosophila ...

[ 1992, 2000, 2008, 2020 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1948 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3, 3, 8 ]

6

true

Family

NADH:ubiquinone oxidoreductase, subunit NDUFB4

NADH_UbQ_OxRdtase_NDUFB4_su

7

IPR009867

9,867

Protein of unknown function DUF1422

DUF1422

Family

1,485

false

This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008278", "PF07226" ]

[ "PRK11056.1", "DUF1422" ]

[ 1440, 1485 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Neoptera", "metagenomes" ]

[ 1481, 2, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1422

DUF1422

1

IPR009868

9,868

VirE2

Family

60

false

This family consists of several VirE2 proteins which seem to be specific to Agrobacterium tumefaciens and Rhizobium etli. VirE2 is known to interact, via its C terminus, with VirD4. A. tumefaciens transfers oncogenic DNA and effector proteins to plant cells during the course of infection. Substrate translocation across...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PFAM" ]

[ "NF010442", "PF07229" ]

[ "PRK13868.1", "VirE2" ]

[ 38, 60 ]

2

[]

0

[ "3btp", "4blf" ]

2

[ "PUB00013053" ]

[ "12950931" ]

[ "VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens." ]

[ 2003 ]

1

[]

0

null

[ "Hyphomicrobiales" ]

[ 60 ]

1

[]

0

true

Family

VirE2

8

IPR009869

9,869

Nematode resistance protein-like HSPRO1, N-terminal

HSPRO1_N

Domain

789

false

This entry represents the N terminus (approximately 180 residues) of plant HSPRO1, which is believed to confer resistance to nematodes [ ]. Proteins containing this domain also include HSPRO2, which is involved in basal resistance [ ].

[ "GO:0006952" ]

[ "defense response" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07231" ]

[ "Hs1pro-1_N" ]

[ 789 ]

1

[]

0

[]

0

[ "PUB00012976", "PUB00074857" ]

[ "12669798", "17977154" ]

[ "Isolation and linkage analysis of expressed disease-resistance gene analogues of sugar beet (Beta vulgaris L.).", "Basal resistance against Pseudomonas syringae in Arabidopsis involves WRKY53 and a protein with homology to a nematode resistance protein." ]

[ 2003, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 784 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 2, 5 ]

3

true

Domain

Nematode resistance protein-like HSPRO1, N-terminal

HSPRO1_N

3

IPR009870

9,870

Putative replication protein DUF1424

DUF1424

Family

91

false

Members of this family seem to be found mainly in Halobacteria. The function of this family is unknown. This protein is probably a replication protein due to conservation of functional motifs.

[]

0

[ "PFAM" ]

[ "PF07232" ]

[ "DUF1424" ]

[ 91 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphapleolipovirus", "Halobacteriales", "Lederbergia galactosidilytica" ]

[ 2, 88, 1 ]

3

[]

0

true

Family

Putative replication protein DUF1424

DUF1424

6

IPR009871

9,871

Movement and RNA silencing protein

MP

Family

213

false

This family consists of several Babuvirus proteins of around 120 residues in length. Proteins in this family include movement and RNA silencing protein (also known as MP) from Banana bunchy top virus. MP acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mec...

[]

0

[ "PFAM" ]

[ "PF07234" ]

[ "Babuvirus_MP" ]

[ 213 ]

1

[]

0

[]

0

[ "PUB00070087" ]

[ "19816653" ]

[ "Identification of two RNA silencing suppressors from banana bunchy top virus." ]

[ 2009 ]

1

[]

0

null

[ "Babuvirus" ]

[ 213 ]

1

[]

0

true

Family

Movement and RNA silencing protein

MP

1

IPR009872

9,872

Protein of unknown function DUF1427

DUF1427

Family

2,604

false

This family consists of several bacterial proteins of around 100 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07235" ]

[ "DUF1427" ]

[ 2604 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "metagenomes" ]

[ 2580, 19, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF1427

DUF1427

6

IPR009873

9,873

Phytoreovirus S7

Phytoreo_S7

Family

11

false

This family consists of several Phytoreovirus S7 proteins which are thought to be viral core proteins [ ].

[]

0

[ "PFAM" ]

[ "PF07236" ]

[ "Phytoreo_S7" ]

[ 11 ]

1

[]

0

[ "1uf2" ]

1

[ "PUB00013055" ]

[ "2313270" ]

[ "Sequence analysis and product assignment of segment 7 of the rice dwarf virus genome." ]

[ 1990 ]

1

[]

0

null

[ "Phytoreovirus" ]

[ 11 ]

1

[]

0

true

Family

Phytoreovirus S7

Phytoreo_S7

6

IPR009874

9,874

Protein of unknown function DUF1428

DUF1428

Family

3,937

false

This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07237", "PIRSF007028" ]

[ "DUF1428", "UCP007028" ]

[ 3937, 3423 ]

2

[]

0

[ "2okq" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 54, 3855, 6, 22 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1428

DUF1428

5

IPR009875

9,875

PilZ domain

PilZ_domain

Domain

45,344

false

The ubiquitous bacterial second messenger cyclic-di-GMP (c-di-GMP) is associated with the regulation of biofilm formation, the control of exopolysaccharide synthesis, flagellar- and pili-based motility, gene expression, interactions of bacteria with eukaryotic hosts and multicellular behaviour in diverse bacteria. This...

[ "GO:0035438" ]

[ "cyclic-di-GMP binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PFAM" ]

[ "PF07238", "PF22006" ]

[ "PilZ", "PilZ-like" ]

[ 45323, 21 ]

2

[ "REACTOME" ]

[ "R-HSA-9931953" ]

[ "REACTOME:R-HSA-9931953" ]

1

[ "1yln", "1ywu", "2gjg", "2l74", "2rde", "3cnr", "3dsg", "3kyf", "3kyg", "4f48", "4fou", "4hg6", "4i86", "4p00", "4p02", "4q63", "4rt0", "4rt1", "4xrn", "5eiy", "5ej1", "5ejz", "5vx6", "5xly", "5y4r", "5y6f", "5y6g", "7lby", "7lkm", "7lkn", "7lko", "7lkq"...

38

[ "PUB00049330", "PUB00054999", "PUB00055000", "PUB00098203" ]

[ "18034161", "16249258", "16920715", "31740493" ]

[ "The structural basis of cyclic diguanylate signal transduction by PilZ domains.", "PilZ domain is part of the bacterial c-di-GMP binding protein.", "The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria.", "Structural Conservation an...

[ 2007, 2006, 2006, 2020 ]

4

[]

[ "IPR011752" ]

0

1

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 44502, 3, 31, 3, 805 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

PilZ domain

PilZ_domain

7

IPR009876

9,876

Outer membrane adhesin OpcA

OM_adhesin_OpcA

Family

81

false

This entry represents OpcA-type outer membrane adhesion proteins. OpcA (formerly called 5C) was isolated from Neisseria meningitidis, causative agent of meningococcal meningitis and septicemia. An outer membrane protein embedded in the lipid bilayer, OpcA was shown to play an important role in meningococcal adhesion an...

[]

0

[ "PFAM" ]

[ "PF07239" ]

[ "OpcA" ]

[ 81 ]

1

[]

0

[ "1k24", "2vdf" ]

2

[ "PUB00013057", "PUB00028792", "PUB00035658" ]

[ "12706886", "11891340", "17114231" ]

[ "Identification of opcA gene in Neisseria polysaccharea: interspecies diversity of Opc protein family.", "Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis.", "Membrane simulations of OpcA: gating in the loops?" ]

[ 2003, 2002, 2007 ]

3

[]

0

null

[ "Neisseriaceae" ]

[ 81 ]

1

[]

0

true

Family

Outer membrane adhesin OpcA

OM_adhesin_OpcA

4

IPR009879

9,879

Phlebovirus nonstructural NS-M

Phlebovirus_NSM

Domain

240

false

This entry consists of several Phlebovirus nonstructural NS-M proteins, which represent the N-terminal region of the M polyprotein precursor. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07246" ]

[ "Phlebovirus_NSM" ]

[ 240 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Phlebovirus" ]

[ 240 ]

1

[]

0

true

Domain

Phlebovirus nonstructural NS-M

Phlebovirus_NSM

8

IPR009880

9,880

Glyoxal oxidase, N-terminal

Glyoxal_oxidase_N

Domain

11,277

false

This entry represents the N terminus (approximately 300 residues) of a number of plant and fungal glyoxal oxidase enzymes. Glyoxal oxidase catalyses the oxidation of aldehydes to carboxylic acids, coupled with reduction of dioxygen to hydrogen peroxide. It is an essential component of the extracellular lignin degradati...

[]

0

[ "PFAM" ]

[ "PF07250" ]

[ "Glyoxal_oxid_N" ]

[ 11277 ]

1

[]

0

[ "1gof", "1gog", "1goh", "1k3i", "1t2x", "2eib", "2eic", "2eid", "2eie", "2jkx", "2vz1", "2vz3", "2wq8", "4unm", "6xlr", "6xls", "6xlt", "8tx5", "8tx6", "9g43", "9g8h" ]

21

[ "PUB00013062" ]

[ "10593910" ]

[ "Identification of catalytic residues in glyoxal oxidase by targeted mutagenesis." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 5, 1257, 10012, 3 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 2, 10, 17 ]

4

true

Domain

Glyoxal oxidase, N-terminal

Glyoxal_oxidase_N

4

IPR009881

9,881

Protein of unknown function DUF1433

DUF1433

Family

814

false

This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.

[]

0

[ "PFAM" ]

[ "PF07252" ]

[ "DUF1433" ]

[ 814 ]

1

[]

0

[ "2k3d" ]

1

[]

0

[]

0

null

[ "Bacillota" ]

[ 814 ]

1

[]

0

true

Family

Protein of unknown function DUF1433

DUF1433

3

IPR009882

9,882

Gypsy

Family

426

false

This family consists of several Gypsy/Env proteins from Drosophila and Ceratitis fruit fly species. Gypsy is an endogenous retrovirus of Drosophila melanogaster. Phylogenetic studies suggest that occasional horizontal transfer events of gypsy occur between Drosophila species. Gypsy possesses infective properties associ...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07253", "PIRSF003841" ]

[ "Gypsy", "Gypsy" ]

[ 405, 64 ]

2

[]

0

[]

0

[ "PUB00013063" ]

[ "11805056" ]

[ "Comparative and functional studies of Drosophila species invasion by the gypsy endogenous retrovirus." ]

[ 2002 ]

1

[]

0

null

[ "Opisthokonta", "Riboviria" ]

[ 417, 9 ]

2

[ "Drosophila melanogaster" ]

[ 21 ]

1

true

Family

Gypsy

8

IPR009883

9,883

Inner membrane protein YgfX

YgfX

Family

3,366

false

This family includes bacterial proteins including the probable inner membrane protein YgfX from Escherichia coli (formerly known as CptA). This had been thought to be a toxin, but it has no effect on cell growth [ ]. It has been shown to interact with the cytoskeletal proteins FtsZ and MreB and to inhibit FtsZ GTP-depe...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07254", "PIRSF020653" ]

[ "Cpta_toxin", "UCP020653" ]

[ 3366, 1023 ]

2

[]

0

[]

0

[ "PUB00066693", "PUB00075551", "PUB00083888" ]

[ "22474332", "22239607", "23657679" ]

[ "SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.", "A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli.", "YgfX (CptA) is a multimeric membrane protein that interacts wit...

[ 2012, 2012, 2013 ]

3

[]

0

null

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 3348, 2, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YgfX

YgfX

1

IPR009885

9,885

Protein of unknown function DUF1435

DUF1435

Family

1,235

false

This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07256" ]

[ "DUF1435" ]

[ 1235 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1234, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1435

DUF1435

2

IPR009887

9,887

Progressive ankylosis

ANKH

Family

1,509

false

This family consists of several progressive ankylosis protein (ANK or ANKH) sequences, also known as Mineralization regulator ANKH in mammals. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PP i ), a major inhibitor of physiologic and pathologic calcification, bone mineralisation an...

[ "GO:0005315", "GO:0035435", "GO:0016020" ]

[ "phosphate transmembrane transporter activity", "phosphate ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF07260", "PTHR28384" ]

[ "ANKH", "" ]

[ 1437, 1478 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-5223345", "R-HSA-5223345", "R-MMU-5223345", "R-RNO-5223345" ]

[ "REACTOME:R-DRE-5223345", "REACTOME:R-HSA-5223345", "REACTOME:R-MMU-5223345", "REACTOME:R-RNO-5223345" ]

4

[]

0

[ "PUB00013069", "PUB00013070" ]

[ "11326272", "11326338" ]

[ "Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.", "Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 171, 1332, 6 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 3, 4 ]

4

true

Family

Progressive ankylosis

ANKH

1

IPR009888

9,888

Immunity protein CdiI, Proteobacteria type

CdiI_Proteobact

Family

636

false

Contact-dependent growth inhibition (CDI) toxins are expressed by Gram-negative bacteria as part of a mechanism to inhibit the growth of neighbouring bacteria. This entry includes the inhibitor (CdiI) of the CdiA effector protein from Escherichia coli EC869 (which is a DNAse). CdiA secretion is dependent on the outer m...

[]

0

[ "PFAM", "CDD" ]

[ "PF07262", "cd13445" ]

[ "CdiI", "CDI_inhibitor_EC869_like" ]

[ 635, 409 ]

2

[]

0

[ "2gkp", "4g6u", "4zqu", "4zqv", "4zqw" ]

5

[ "PUB00057480", "PUB00065129" ]

[ "21085179", "23236156" ]

[ "A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria.", "Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems." ]

[ 2010, 2012 ]

2

[]

0

null

[ "Bacteria", "Parastrongyloides trichosuri", "marine sediment metagenome" ]

[ 633, 1, 2 ]

3

[]

0

true

Family

Immunity protein CdiI, Proteobacteria type

CdiI_Proteobact

3

IPR009889

9,889

Dentin matrix 1

DMP1

Family

1,077

false

This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 [ ]. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localised in the nuclear compa...

[ "GO:0001503", "GO:0030198" ]

[ "ossification", "extracellular matrix organization" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07263", "PTHR23400" ]

[ "DMP1", "" ]

[ 1051, 1052 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3000178", "R-HSA-381426", "R-HSA-8957275", "R-MMU-3000178", "R-MMU-381426", "R-MMU-8957275", "R-RNO-3000178", "R-RNO-381426", "R-RNO-8957275" ]

[ "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-3000178", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-3000178", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

9

[]

0

[ "PUB00013072", "PUB00013073", "PUB00013074" ]

[ "9177774", "12615915", "12929940" ]

[ "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.", "Dual functional roles of dentin matrix protein 1. Implications in biomineralization an...

[ 1997, 2003, 2003 ]

3

[]

0

null

[ "Tetrapoda" ]

[ 1077 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5 ]

3

true

Family

Dentin matrix 1

DMP1

4

IPR009891

9,891

Tapetum specific TAP35/TAP44

TAP35_44

Family

123

false

This family consists of several plant tapetum specific proteins. Members of this family are found in Arabidopsis thaliana, Brassica napus and Sinapis alba. Members of this family may be involved in sporopollenin formation and/or deposition [ ].

[]

0

[ "PFAM" ]

[ "PF07265" ]

[ "TAP35_44" ]

[ 123 ]

1

[]

0

[]

0

[ "PUB00013077" ]

[ "7764317" ]

[ "The proteins encoded by two tapetum-specific transcripts, Sa tap35 and Sa tap44, from Sinapis alba L. are localized in the exine cell wall layer of developing microspores." ]

[ 1994 ]

1

[]

0

null

[ "Brassicaceae" ]

[ 123 ]

1

[ "Arabidopsis thaliana" ]

[ 8 ]

1

true

Family

Tapetum specific TAP35/TAP44

TAP35_44

3

IPR009893

9,893

Nucleopolyhedrovirus capsid P80/P87

Nucleo_P80/P87

Family

152

false

This family consists of several nuclear polyhedrosis viruses capsid P80 and P87 protein sequences [ ]. P87 is expressed late in infection and concentrated in infected cell nuclei [ ]. P80 (VP80) is involved in the packaging of nucleocapsids and in the egress of progeny nucleocapsids from the virogenic stroma toward the...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF07267", "PIRSF003639" ]

[ "Nucleo_P87", "Nucleo_P87" ]

[ 152, 45 ]

2

[]

0

[ "8i8b", "8vwi", "8vwj", "9h2a", "9h2b", "9h2j" ]

6

[ "PUB00013078", "PUB00073478", "PUB00081413", "PUB00081414" ]

[ "2184573", "1529529", "21450830", "21449023" ]

[ "A capsid-associated protein of the multicapsid nuclear polyhedrosis virus of Orgyia pseudotsugata: genetic location, sequence, transcriptional mapping, and immunocytochemical characterization.", "Nucleotide sequence and transcriptional analysis of the p80 gene of Autographa californica nuclear polyhedrosis virus...

[ 1990, 1992, 2011, 2011 ]

4

[]

0

null

[ "Alphabaculovirus", "Prorocentrum micans" ]

[ 151, 1 ]

2

[]

0

true

Family

Nucleopolyhedrovirus capsid P80/P87

Nucleo_P80/P87

8

IPR009894

9,894

Exported

EppA_BapA

Family

95

false

This family consists of a number of exported protein precursor (EppA and BapA) sequences which seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). bapA gene sequences are quite stable but the encoded proteins do not provoke a strong immune response in most individuals. Conversely, EppA proteins are m...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF033732", "PF07268" ]

[ "borfam95", "EppA_BapA" ]

[ 90, 95 ]

2

[]

0

[]

0

[ "PUB00013079", "PUB00095231" ]

[ "12724373", "22544270" ]

[ "Immunological and genetic characterization of Borrelia burgdorferi BapA and EppA proteins.", "EbfC (YbaB) is a new type of bacterial nucleoid-associated protein and a global regulator of gene expression in the Lyme disease spirochete." ]

[ 2003, 2012 ]

2

[]

0

null

[ "Borreliaceae" ]

[ 95 ]

1

[]

0

true

Family

Exported

EppA_BapA

3

IPR009895

9,895

Protein of unknown function DUF1438

DUF1438

Family

34

false

This family consists of several hypothetical proteins of around 170 residues in length predominantly found in rodents. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07270", "PTHR31647" ]

[ "DUF1438", "" ]

[ 34, 34 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Muroidea" ]

[ 34 ]

1

[ "Mus musculus" ]

[ 13 ]

1

true

Family

Protein of unknown function DUF1438

DUF1438

3

IPR009896

9,896

Cytadhesin P30/P32

Cytadhesin_P30/P32

Family

235

false

This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localised on the tip organelle. It is thought that it is important in cytadherence and virulence [ ].

[ "GO:0044650", "GO:0016020" ]

[ "adhesion of symbiont to host cell", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07271" ]

[ "Cytadhesin_P30" ]

[ 235 ]

1

[]

0

[]

0

[ "PUB00013081" ]

[ "9632619" ]

[ "Characterization of MGC2, a Mycoplasma gallisepticum cytadhesin with homology to the Mycoplasma pneumoniae 30-kilodalton protein P30 and Mycoplasma genitalium P32." ]

[ 1998 ]

1

[]

0

null

[ "Bilateria", "Mycoplasmatota" ]

[ 9, 226 ]

2

[]

0

true

Family

Cytadhesin P30/P32

Cytadhesin_P30/P32

4

IPR009899

9,899

Antirestriction

ArdA

Family

4,536

false

This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification [ ].

[]

0

[ "PFAM" ]

[ "PF07275" ]

[ "ArdA" ]

[ 4536 ]

1

[]

0

[ "2w82", "7bto", "7btr" ]

3

[ "PUB00013083" ]

[ "12618468" ]

[ "Plasmid R16 ArdA protein preferentially targets restriction activity of the type I restriction-modification system EcoKI." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Plasmid pKM101", "unclassified sequences" ]

[ 4423, 62, 2, 1, 48 ]

5

[]

0

true

Family

Antirestriction

ArdA

9

IPR009900

9,900

Apopolysialoglycoprotein

PSGP

Repeat

89

false

This entry represents a series of 13 residue repeats found in the apopolysialoglycoprotein of Oncorhynchus mykiss (Rainbow trout) and Oncorhynchus masou (Cherry salmon). Polysialoglycoprotein (PSGP) of unfertilised eggs of rainbow trout consists of tandem repeats of a glycotridecapeptide, Asp-Asp-Ala-Thr*-Ser*-Glu-Ala-...

[]

0

[ "PFAM" ]

[ "PF07276" ]

[ "PSGP" ]

[ 89 ]

1

[]

0

[]

0

[ "PUB00013084" ]

[ "3182867" ]

[ "Molecular cloning and characterization of cDNAs coding for apo-polysialoglycoprotein of rainbow trout eggs. Multiple mRNA species transcribed from multiple genes contain diverged numbers of exact 39-base (13-amino acid) repeats." ]

[ 1988 ]

1

[]

0

null

[ "Mycobacterium spongiae", "Salmoninae" ]

[ 1, 88 ]

2

[]

0

true

Repeat

Apopolysialoglycoprotein

PSGP

4

IPR009901

9,901

Bacteriophage VT1-Sakai, H0025

Phage_VT1-Sakai_H0025

Family

1,218

false

This entry is represented by Bacteriophage VT1-Sakai, H0025 ( ]. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. It also includes several hypothetical Enterobacterial proteins of around 160 residues in length.

[]

0

[ "PFAM" ]

[ "PF07278" ]

[ "DUF1441" ]

[ 1218 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 1131, 82, 5 ]

3

[]

0

true

Family

Bacteriophage VT1-Sakai, H0025

Phage_VT1-Sakai_H0025

9

IPR009902

9,902

Protein of unknown function DUF1442

DUF1442

Family

2,657

false

This family consists of several hypothetical Arabidopsis thaliana proteins of around 225 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07279", "PTHR33593" ]

[ "DUF1442", "" ]

[ 2632, 2516 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta", "mine drainage metagenome" ]

[ 2656, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 6, 2 ]

3

true

Family

Protein of unknown function DUF1442

DUF1442

4

IPR009903

9,903

Per os infectivity factor AC110

AcMNPV_AC110

Family

109

false

This family of Baculovirus proteins includes Autographa californica nuclear polyhedrosis virus (AcMNPV) Per os infectivity factor AC110, which is required for oral infectivity. It may play a role after occlusion-derived virions pass through the host's peritrophic membrane [ ].

[]

0

[ "PFAM" ]

[ "PF07280" ]

[ "Ac110_PIF" ]

[ 109 ]

1

[]

0

[]

0

[ "PUB00082597" ]

[ "27212681" ]

[ "The Autographa californica multiple nucleopolyhedrovirus ac110 gene encodes a new per os infectivity factor." ]

[ 2016 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 109 ]

1

[]

0

true

Family

Per os infectivity factor AC110

AcMNPV_AC110

3

IPR009905

9,905

2-vinyl bacteriochlorophyllide hydratase

BCHF

Family

701

false

This family contains the bacterial enzyme 2-vinyl bacteriochlorophyllide hydratase (approximately 150 residues long). This is involved in the light-independent bacteriochlorophyll biosynthesis pathway by adding water across the 2-vinyl group [ ].This enzyme is apparently absent from cyanobacteria (which do not use bact...

[ "GO:0016836", "GO:0019685", "GO:0030494" ]

[ "hydro-lyase activity", "photosynthesis, dark reaction", "bacteriochlorophyll biosynthetic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM", "NCBIFAM" ]

[ "PF07284", "TIGR02020" ]

[ "BCHF", "BchF" ]

[ 701, 699 ]

2

[ "GP" ]

[ "GenProp0146" ]

[ "GP:GenProp0146" ]

1

[]

0

[ "PUB00008141" ]

[ "8385667" ]

[ "bchFNBH bacteriochlorophyll synthesis genes of Rhodobacter capsulatus and identification of the third subunit of light-independent protochlorophyllide reductase in bacteria and plants." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Effrenium voratum", "freshwater sediment metagenome" ]

[ 699, 1, 1 ]

3

[]

0

true

Family

2-vinyl bacteriochlorophyllide hydratase

BCHF

5

IPR009906

9,906

D-glutamate cyclase-like domain

D-Glu_cyclase

Domain

6,669

false

This entry represents a domain found at the N-terminal of mitochondrial D-glutamate cyclase ( ), which converts D-glutamate to 5-oxo-D-proline [ ]. This domain is also found in numerous uncharacterised proteins from bacteria.

[]

0

[ "PFAM" ]

[ "PF07286" ]

[ "D-Glu_cyclase" ]

[ 6669 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "4.2.1.-", "PWY-2229", "PWY-2467", "PWY-5061", "PWY-5367", "PWY-5408", "PWY-5409", "PWY-5410", "PWY-5644", "PWY-5780", "PWY-5793", "PWY-5979", "PWY-6322", "PWY-6602", "PWY-6627", "PWY-6672", "PWY-6679", "PWY-6721", "PWY-6749", "PWY-6944", "PWY-6945", "PWY-6946", "PWY-6948...

[ "EC:4.2.1.-", "METACYC:PWY-2229", "METACYC:PWY-2467", "METACYC:PWY-5061", "METACYC:PWY-5367", "METACYC:PWY-5408", "METACYC:PWY-5409", "METACYC:PWY-5410", "METACYC:PWY-5644", "METACYC:PWY-5780", "METACYC:PWY-5793", "METACYC:PWY-5979", "METACYC:PWY-6322", "METACYC:PWY-6602", "METACYC:PWY-6...

53

[ "2pif", "3db9" ]

2

[ "PUB00086027" ]

[ "28266638" ]

[ "D-Glutamate is metabolized in the heart mitochondria." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4616, 1980, 73 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 12, 3, 5, 1 ]

5

true

Domain

D-glutamate cyclase-like domain

D-Glu_cyclase

3

IPR009907

9,907

RNA polymerase epsilon subunit

RpoY

Family

2,324

false

RNA polymerase in bacteria is a multisubunit protein complex that is essential for gene expression. This entry represents the epsilon subunit encoded by the rpoY gene. The structure of epsilon shows simple β-sheet with an α-helix running diagonally along the back of the structure forming a β-β-α-β fold [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01553", "NF010188", "PF07288" ]

[ "RNApol_bact_RpoY", "PRK13667.1", "RpoY" ]

[ 2277, 2175, 2324 ]

3

[ "EC" ]

[ "2.7.7.6" ]

[ "EC:2.7.7.6" ]

1

[ "4njc", "6wvk", "6zca", "6zfb", "7ckq", "7f75", "8x6f", "8x6g", "8xa6", "8xa7", "8xa8" ]

11

[ "PUB00095126" ]

[ "25092033" ]

[ "?, a new subunit of RNA polymerase found in gram-positive bacteria." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2320, 1, 3 ]

3

[]

0

true

Family

RNA polymerase epsilon subunit

RpoY

7

IPR009908

9,908

Methylamine utilisation protein, MauE

Methylamine_util_MauE

Domain

13,321

false

This entry consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-...

[ "GO:0030416", "GO:0016020" ]

[ "methylamine metabolic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07291" ]

[ "MauE" ]

[ 13321 ]

1

[]

0

[]

0

[ "PUB00013087" ]

[ "9403107" ]

[ "MauE and MauD proteins are essential in methylamine metabolism of Paracoccus denitrificans." ]

[ 1997 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 39, 12982, 15, 2, 283 ]

5

[]

0

true

Domain

Methylamine utilisation protein, MauE

Methylamine_util_MauE

6

IPR009909

9,909

Nmi/IFP 35 domain

Nmi/IFP35_dom

Domain

2,116

false

This entry represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localisation [ ]. This domain is predicted to contain a region that is swapp...

[]

0

[ "PFAM" ]

[ "PF07292" ]

[ "NID" ]

[ 2116 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-909733", "R-HSA-9692916" ]

[ "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9692916" ]

2

[]

0

[ "PUB00013088" ]

[ "10950963" ]

[ "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35." ]

[ 2000 ]

1

[]

0

null

[ "Deuterostomia" ]

[ 2116 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 5, 4, 8 ]

4

true

Domain

Nmi/IFP 35 domain

Nmi/IFP35_dom

6

IPR009910

9,910

Protein of unknown function DUF1450

DUF1450

Family

3,282

false

This entry consists of several hypothetical bacterial proteins of around 80 residues in length representing two families. Members contain four highly conserved cysteine residues and their function is unknown.

[]

0

[ "PFAM" ]

[ "PF07293" ]

[ "DUF1450" ]

[ 3282 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR020880", "IPR022916" ]

0

2

0

[ "Bacteria", "Halobacteriales", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 3271, 7, 1, 3 ]

4

[]

0

true

Family

Protein of unknown function DUF1450

DUF1450

6

IPR009911

9,911

Fibroin P25

Fibroin_P25

Family

149

false

This family consists of several insect fibroin P25 proteins. Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25. The heavy and light chains are linked by a disulphide bond, and P25 associates with disulphide-linked heavy and light chains by noncovalent in...

[ "GO:0005198", "GO:0005576" ]

[ "structural molecule activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF07294", "PIRSF008881" ]

[ "Fibroin_P25", "Fibroin_P25" ]

[ 149, 40 ]

2

[]

0

[]

0

[ "PUB00013089" ]

[ "10986287" ]

[ "Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio." ]

[ 2000 ]

1

[]

0

null

[ "Chitinophaga agrisoli", "Ditrysia" ]

[ 3, 146 ]

2

[]

0

true

Family

Fibroin P25

Fibroin_P25

7

IPR009912

9,912

Zinc-ribbon containing domain

DUF1451

Family

2,728

false

This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein.

[]

0

[ "PFAM" ]

[ "PF07295" ]

[ "DUF1451" ]

[ 2728 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Trichuris trichiura", "unclassified sequences" ]

[ 2635, 46, 1, 46 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Zinc-ribbon containing domain

DUF1451

1

IPR009915

9,915

NnrU domain

NnrU_dom

Domain

5,614

false

This entry represents a domain found in bacterial NnrU proteins. It can also be found in plant 15-cis-zeta-carotene isomerase (Z-ISO). NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that NnrU and perhaps NnrT are required for expression of b...

[]

0

[ "PFAM" ]

[ "PF07298" ]

[ "NnrU" ]

[ 5614 ]

1

[ "EC", "METACYC" ]

[ "2.1.1.334", "PWY-7793" ]

[ "EC:2.1.1.334", "METACYC:PWY-7793" ]

2

[]

0

[ "PUB00013091", "PUB00077046" ]

[ "9171397", "20335404" ]

[ "Characterization of the nitric oxide reductase-encoding region in Rhodobacter sphaeroides 2.4.3.", "Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants." ]

[ 1997, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 4696, 832, 30, 56 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 2, 4 ]

3

true

Domain

NnrU domain

NnrU_dom

5

IPR009917

9,917

SRA1/Sec31

Domain

2,673

false

This domain can be found in several hypothetical mammalian steroid receptor RNA activator proteins. The SRA-RNAs encode stable proteins that are widely expressed and upregulated in breast cancer cell lines. SRA-RNA is a steroid receptor co-activator which acts as a functional RNA [ ]. This domain is also found at the C...

[]

0

[ "PFAM" ]

[ "PF07304" ]

[ "SRA1" ]

[ 2673 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-204005", "R-SPO-204005" ]

[ "REACTOME:R-SCE-204005", "REACTOME:R-SPO-204005" ]

2

[ "2mgx", "2yru", "4bzj", "4bzk", "4nbo", "6zg5", "6zg6", "6zl0" ]

8

[ "PUB00090750", "PUB00090763" ]

[ "27282881", "9190202" ]

[ "Steroid receptor RNA activator: Biologic function and role in disease.", "Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum." ]

[ 2016, 1997 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2673 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 3, 4, 1, 5, 1, 1 ]

8

true

Domain

SRA1/Sec31

6

IPR009918

9,918

Protein of unknown function DUF1454

DUF1454

Family

1,292

false

This family consists of several Enterobacterial sequences of around 200 residues in length, which are often known as YiiQ proteins. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07305" ]

[ "DUF1454" ]

[ 1292 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1288, 2, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1454

DUF1454

4

IPR009919

9,919

Protein of unknown function DUF1455

DUF1455

Family

9

false

This family consists of several hypothetical putative outer membrane proteins which appear to be specific to Anaplasma marginale and Anaplasma ovis.

[]

0

[ "PFAM" ]

[ "PF07306" ]

[ "DUF1455" ]

[ 9 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Anaplasma" ]

[ 9 ]

1

[]

0

true

Family

Protein of unknown function DUF1455

DUF1455

1

IPR009920

9,920

Heptaprenyl diphosphate synthase subunit 1

HEPPP_synth_su1

Family

1,622

false

This family contains subunit 1 of bacterial heptaprenyl diphosphate synthase (HEPPP synthase) ( ) (approximately 230 residues long). The enzyme consists of two subunits, both of which are required for catalysis of heptaprenyl diphosphate synthesis, the precursor for the side chain of the isoprenoid quinone menaquinone-...

[ "GO:0009234" ]

[ "menaquinone biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07307" ]

[ "HEPPP_synt_1" ]

[ 1622 ]

1

[]

0

[]

0

[ "PUB00013095", "PUB00053776" ]

[ "9748348", "9720033" ]

[ "Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex.", "The gerC locus of Bacillus subtilis, required for menaquinone biosynthesis, is concerned only indirectly with spore germination." ]

[ 1998, 1998 ]

2

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432" ]

[ 1621, 1 ]

2

[]

0

true

Family

Heptaprenyl diphosphate synthase subunit 1

HEPPP_synth_su1

5

IPR009921

9,921

YehS-like

Family

5,139

false

This entry represents a family of bacterial proteins that includes Uncharacterized protein YehS from Escherichia coli, which appears to be associated with growth in the presence of n-butanol or n-hexane [ ]. This protein is predicted to have an all-α structure.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07308", "PTHR37805" ]

[ "DUF1456", "" ]

[ 5139, 5121 ]

2

[]

0

[]

0

[ "PUB00101786" ]

[ "30234107" ]

[ "CRISPR Gene Perturbations Provide Insights for Improving Bacterial Biofuel Tolerance." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5091, 5, 43 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YehS-like

3

IPR009922

9,922

Protein of unknown function DUF1457

DUF1457

Family

3,004

false

This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. Members of this group contain a domain that is distantly similar to other PAS domains.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07310", "PIRSF031878" ]

[ "PAS_5", "UCP031878" ]

[ 3004, 822 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2977, 5, 22 ]

3

[]

0

true

Family

Protein of unknown function DUF1457

DUF1457

1

IPR009923

9,923

Dodecin

Family

7,420

false

Dodecin flavoprotein is a small dodecameric flavin-binding protein from Halobacterium salinarium (Halobacterium halobium) that contains two flavins stacked in a single binding pocket between two tryptophan residues to form an aromatic tetrade [ ]. Dodecin binds riboflavin, although it appears to have a broad specificit...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07311", "PTHR39324" ]

[ "Dodecin", "" ]

[ 7420, 7016 ]

2

[]

0

[ "1mog", "2cc6", "2cc7", "2cc8", "2cc9", "2ccb", "2ccc", "2cie", "2cif", "2cjc", "2cz8", "2deg", "2deh", "2dev", "2ux9", "2v18", "2v19", "2v21", "2vkf", "2vkg", "2vx9", "2vxa", "2vyx", "2yiz", "2yj0", "3onr", "3oqt", "4b2h", "4b2j", "4b2k", "4b2m", "6r1e"...

33

[ "PUB00027394", "PUB00035544", "PUB00049943" ]

[ "12679016", "16460756", "19224924" ]

[ "Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum.", "Dodecins: a family of lumichrome binding proteins.", "Dodecin is the key player in flavin homeostasis of archaea." ]

[ 2003, 2006, 2009 ]

3

[]

[ "IPR050049" ]

0

1

0

[ "Archaea", "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 451, 6842, 6, 121 ]

4

[]

0

true

Family

Dodecin

9

IPR009925

9,925

Protein of unknown function DUF1463

DUF1463

Family

145

false

This entry represents a family of hypothetical proteins of around 140 residues in length found in Borrelia species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07316" ]

[ "DUF1463" ]

[ 145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 145 ]

1

[]

0

true

Family

Protein of unknown function DUF1463

DUF1463

7

IPR009926

9,926

Type III secretion system flagellar brake protein YcgR, PilZN domain

T3SS_YcgR_PilZN

Domain

7,287

false

This entry represents the N-terminal domain of YcgR proteins, located N-terminal to PilZ domains, thus named PilZN domain (also known as YcgR domain) [ ]. The function of this domain is not known, but it is known to interact with the C-terminal which has cyclic-di-GMP bound [ ]. YcgR is involved in the flagellar motor ...

[]

0

[ "PFAM", "PFAM" ]

[ "PF07317", "PF12945" ]

[ "PilZN", "PilZNR" ]

[ 3580, 3707 ]

2

[]

0

[ "1yln", "2gjg", "2rde", "3kyf", "3kyg", "5vx6", "5y6f", "5y6h" ]

8

[ "PUB00013097", "PUB00049330", "PUB00055001", "PUB00098203" ]

[ "11031114", "18034161", "20346719", "31740493" ]

[ "Two novel flagellar components and H-NS are involved in the motor function of Escherichia coli.", "The structural basis of cyclic diguanylate signal transduction by PilZ domains.", "The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a \"backstop brake\" mecha...

[ 2000, 2007, 2010, 2020 ]

4

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 7195, 3, 89 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Type III secretion system flagellar brake protein YcgR, PilZN domain

T3SS_YcgR_PilZN

2

IPR009928

9,928

Primosomal DnaI, N-terminal

DnaI_N

Domain

3,207

false

This entry represents the N terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase [...

[]

0

[ "PFAM" ]

[ "PF07319" ]

[ "DnaI_N" ]

[ 3207 ]

1

[]

0

[ "2k7r", "2qgz", "4m4w" ]

3

[ "PUB00009584" ]

[ "11679082" ]

[ "DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Lecanosticta acicola", "Vedamuthuvirus", "metagenomes" ]

[ 3199, 1, 5, 2 ]

4

[]

0

true

Domain

Primosomal DnaI, N-terminal

DnaI_N

2

IPR009929

9,929

Type III secretion sytem,YscO

T3SS_YscO

Family

502

false

This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis [ ].

[]

0

[ "PFAM" ]

[ "PF07321" ]

[ "YscO" ]

[ 502 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "4mh6" ]

1

[ "PUB00013099" ]

[ "9683485" ]

[ "YscO of Yersinia pestis is a mobile core component of the Yop secretion system." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "invertebrate metagenome" ]

[ 489, 12, 1 ]

3

[]

0

true

Family

Type III secretion sytem,YscO

T3SS_YscO

7

IPR009930

9,930

Structural protein Vp10, Seadornavirus

Seadorna_Vp10

Family

30

false

This entry represents Vp10 protein from Seadornavirus. It is around 240 residues in length. Vp10 forms the virion spike "foot" and helps anchor the Vp9 spike "head" protein in the virion [ ].

[]

0

[ "PFAM" ]

[ "PF07322" ]

[ "Seadorna_Vp10" ]

[ 30 ]

1

[ "GP" ]

[ "GenProp1016" ]

[ "GP:GenProp1016" ]

1

[ "8k42", "8k49", "8k4a", "8w9p", "8w9q", "8w9r" ]

6

[ "PUB00038053" ]

[ "15642258" ]

[ "The structure and function of the outer coat protein VP9 of Banna virus." ]

[ 2005 ]

1

[]

0

null

[ "Seadornavirus", "viral metagenome" ]

[ 29, 1 ]

2

[]

0

true

Family

Structural protein Vp10, Seadornavirus

Seadorna_Vp10

9

IPR009931

9,931

Curtovirus V2

Curto_V2

Family

132

false

This family consists of several Curtovirus V2 proteins. The exact function of V2 is unclear but it is known that the protein is required for a successful host infection process [ ].

[]

0

[ "PFAM" ]

[ "PF07325" ]

[ "Curto_V2" ]

[ 132 ]

1

[]

0

[]

0

[ "PUB00005619" ]

[ "9123819" ]

[ "Genetic analysis of the monopartite tomato yellow leaf curl geminivirus: roles of V1, V2, and C2 ORFs in viral pathogenesis." ]

[ 1997 ]

1

[]

0

null

[ "Geminiviridae" ]

[ 132 ]

1

[]

0

true

Family

Curtovirus V2

Curto_V2

9

IPR009932

9,932

RCS1

Family

1,239

false

RCS1 (also known as FAM64A, CATS or PIMREG) is a substrate of APC/C. It may control the metaphase to anaphase transition [ ]. It is also a substrate of the Kinase Interacting Stathmin (KIS). RCS1 is highly expressed in cancer cell lines in a cell cycle dependent manner and is induced by mitogens [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07326", "PTHR35819" ]

[ "RCS1", "" ]

[ 1239, 1229 ]

2

[]

0

[]

0

[ "PUB00084339", "PUB00084340" ]

[ "18757745", "23419774" ]

[ "RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.", "The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS)." ]

[ 2008, 2013 ]

2

[]

0

null

[ "Vertebrata" ]

[ 1239 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 4, 5 ]

4

true

Family

RCS1

8

IPR009935

9,935

Protein of unknown function DUF1467

DUF1467

Family

2,526

false

This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07330" ]

[ "DUF1467" ]

[ 2526 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "metagenomes" ]

[ 2507, 19 ]

2

[]

0

true

Family

Protein of unknown function DUF1467

DUF1467

9

IPR009936

9,936

Domain of unknown function DUF1468

DUF1468

Domain

19,994

false

This entry represents a domain found in a group of uncharacterised bacterial sequences, including 16.3 kDa protein in TAR-I ttuC' 3'region from the common pathogen of grapevine Agrobacterium vitis [ ]. In most members of this group, this domain covers the whole length of the protein, and many of them are annotated as t...

[]

0

[ "PFAM" ]

[ "PF07331" ]

[ "TctB" ]

[ 19994 ]

1

[]

0

[]

0

[ "PUB00006491" ]

[ "8672817" ]

[ "Characterization and distribution of tartrate utilization genes in the grapevine pathogen Agrobacterium vitis." ]

[ 1996 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 133, 19592, 10, 259 ]

4

[]

0

true

Domain

Domain of unknown function DUF1468

DUF1468

8

IPR009938

9,938

Nmi/IFP 35 domain, N-terminal

Nmi/IFP35_N

Domain

600

false

This entry represents the N terminus of interferon-induced 35kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an α helical configuration [ ]. This group of proteins also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.

[]

0

[ "PFAM" ]

[ "PF07334" ]

[ "IFP_35_N" ]

[ 600 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-909733", "R-HSA-9692916" ]

[ "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9692916" ]

2

[]

0

[ "PUB00013088" ]

[ "10950963" ]

[ "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35." ]

[ 2000 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 600 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 5, 7 ]

3

true

Domain

Nmi/IFP 35 domain, N-terminal

Nmi/IFP35_N

6

IPR009939

9,939

Fungal chitosanase

Chitosanase_fungal

Family

2,556

false

This family consists of chitosanase proteins. Chitin, xylan, 6-O-sulphated chitosan and O-carboxymethyl chitin are indigestible by chitosanase [ ].

[ "GO:0016977" ]

[ "chitosanase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07335", "PTHR42061" ]

[ "Glyco_hydro_75", "" ]

[ 2548, 2441 ]

2

[ "EC" ]

[ "3.2.1.132" ]

[ "EC:3.2.1.132" ]

1

[ "7tvl", "7tvm" ]

2

[ "PUB00013105" ]

[ "11115392" ]

[ "An Aspergillus chitosanase with potential for large-scale preparation of chitosan oligosaccharides." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Opisthokonta" ]

[ 1045, 1, 1510 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Fungal chitosanase

Chitosanase_fungal

5

IPR009941

9,941

Protein of unknown function DUF1473

DUF1473

Family

150

false

This entry represents a family of hypothetical proteins of around 150 residues in length found in Borrelia species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07341" ]

[ "DUF1473" ]

[ 150 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliaceae" ]

[ 150 ]

1

[]

0

true

Family

Protein of unknown function DUF1473

DUF1473

8

IPR009942

9,942

TscT toxin domain

DUF1474

Domain

123

false

This entry represents a domain of unknown function in bacterial proteins of around 100 residues in length. These proteins seem to be found exclusively in Staphylococcus species. The function of these proteins is unknown. This entry includes TscT protein [ ], which is part of the TscT/TscA toxin-antitoxin system, also n...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047366", "PF07342" ]

[ "TscT", "TscT" ]

[ 103, 123 ]

2

[]

0

[]

0

[ "PUB00159162" ]

[ "31375497" ]

[ "Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome", "uncultured Caudovirales phage" ]

[ 121, 1, 1 ]

3

[]

0

true

Domain

TscT toxin domain

DUF1474

7

IPR009943

9,943

Protein of unknown function DUF1475

DUF1475

Family

1,246

false

This family consists of several hypothetical plant proteins of around 250 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07343", "PTHR36318" ]

[ "DUF1475", "" ]

[ 1233, 1119 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 165, 1078, 3 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 4, 14 ]

3

true

Family

Protein of unknown function DUF1475

DUF1475

4

IPR009945

9,945

ATPase inhibitor subunit zeta

ATPase_inh_sub_z

Family

2,698

false

This entry represents zeta-subunits, which are found in alpha-proteobacterial F1F0-ATPase regulatory proteins. The zeta subunit is a potent inhibitor of the alpha-proteobacterial F1FO-ATPase. The inhibitory region resides in the first 14 N-terminal residues of the protein, which protrude from the 4-α-helix bundle struc...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07345", "PIRSF031780" ]

[ "ATPaseInh_sub_z", "UCP031780" ]

[ 2698, 2462 ]

2

[]

0

[ "2kzc", "2ll0", "2mdz", "5dn6", "7vkv" ]

5

[ "PUB00091055", "PUB00091056", "PUB00091057" ]

[ "24522203", "19783785", "24838125" ]

[ "The ζ subunit of the F1FO-ATP synthase of α-proteobacteria controls rotation of the nanomotor with a different structure.", "A novel 11-kDa inhibitory subunit in the F1FO ATP synthase of Paracoccus denitrificans and related alpha-proteobacteria.", "NMR structures of α-proteobacterial ATPase-regulating ζ-subuni...

[ 2014, 2010, 2014 ]

3

[]

0

null

[ "Bacteria", "Syncephalis pseudoplumigaleata", "metagenomes" ]

[ 2655, 1, 42 ]

3

[]

0

true

Family

ATPase inhibitor subunit zeta

ATPase_inh_sub_z

4

IPR009946

9,946

Autographa californica nuclear polyhedrosis virus, Orf4

AcMNPV_Orf4

Family

99

false

This entry is represented by Orf4 in EGT-IAP1 intergenic region fom Autographa californica nuclear polyhedrosis virus (AcMNPV), also known as Uncharacterized 12.2 kDa protein. It is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF07346" ]

[ "DUF1477" ]

[ 99 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphabaculovirus" ]

[ 99 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus, Orf4

AcMNPV_Orf4

1

IPR009947

9,947

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

NDUA7

Family

1,528

false

This family contains the eukaryotic NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (NDUA7 or NDUFA7, also known as NADH:ubiquinone oxidoreductase subunit B14.5a, Complex I-B14.5a). This is approximately 100 residues long, and forms part of a multiprotein complex that resides on the inner mitochondrial mem...

[ "GO:0042773", "GO:0005743" ]

[ "ATP synthesis coupled electron transport", "mitochondrial inner membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07347", "PTHR12485" ]

[ "CI-B14_5a", "" ]

[ 1522, 1472 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

6

[ "5gup", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zk9", "6zkc", "6zkd", "6zke", "6zkf", "6zkg", "6zkh", "6zki", "6zkj", "6zkk"...

220

[ "PUB00005074", "PUB00043561", "PUB00045437", "PUB00086570", "PUB00097152", "PUB00097153" ]

[ "1470679", "10940377", "18394423", "27626371", "31485716", "23527692" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).", "Accessory subunits are in...

[ 1992, 2000, 2008, 2016, 2020, 2013 ]

6

[]

0

null

[ "Eukaryota" ]

[ 1528 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 5, 2, 2 ]

6

true

Family

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

NDUA7

1

IPR009948

9,948

Syd

Family

2,361

false

This family contains the Syd protein that has been implicated in the Sec-dependent transport of polypeptides across the inner membrane in bacteria. Syd has been shown to bind the SecY subunit of membrane-embedded SecYEG heterotrimer (also known as core translocon or SecY complex) which is a conserved protein-conducting...

[ "GO:0009898" ]

[ "cytoplasmic side of plasma membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PFAM", "CDD" ]

[ "MF_01104", "NF003439", "PF07348", "cd16323" ]

[ "Syd", "PRK04968.1", "Syd", "Syd" ]

[ 1944, 2107, 2360, 2307 ]

4

[]

0

[ "3ffv" ]

1

[ "PUB00051956", "PUB00085728", "PUB00085729" ]

[ "19139097", "21632250", "9645430" ]

[ "Structure, binding, and activity of Syd, a SecY-interacting protein.", "The SecY complex: conducting the orchestra of protein translocation.", "Genetic analysis of an essential cytoplasmic domain of Escherichia coli SecY based on resistance to Syd, a SecY-interacting protein." ]

[ 2009, 2011, 1998 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2354, 4, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Syd

5

IPR009949

9,949

Sapovirus VP3

Sapovirus_VP3

Family

165

false

This family consists of several hypothetical Sapovirus VP3 proteins of around 165 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07349" ]

[ "DUF1478" ]

[ 165 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caliciviridae" ]

[ 165 ]

1

[]

0

true

Family

Sapovirus VP3

Sapovirus_VP3

1

IPR009953

9,953

Dinitrogenase reductase ADP-ribosyltransferase

DRA_trans

Family

491

false

This family consists of several bacterial dinitrogenase reductase ADP-ribosyltransferase (DRAT) proteins. Members of this family seem to be specific to Rhodospirillum, Rhodobacter and Azospirillum species. Dinitrogenase reductase ADP-ribosyl transferase (DRAT) carries out the transfer of the ADP-ribose from NAD to the ...

[ "GO:0030701", "GO:0009399" ]

[ "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "nitrogen fixation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07357" ]

[ "DRAT" ]

[ 491 ]

1

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[]

0

[ "PUB00013113" ]

[ "11160092" ]

[ "Effect of P(II) and its homolog GlnK on reversible ADP-ribosylation of dinitrogenase reductase by heterologous expression of the Rhodospirillum rubrum dinitrogenase reductase ADP-ribosyl transferase-dinitrogenase reductase-activating glycohydrolase regulatory system in Klebsiella pneumoniae." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Rotaria sordida", "metagenomes" ]

[ 477, 3, 11 ]

3

[]

0

true

Family

Dinitrogenase reductase ADP-ribosyltransferase

DRA_trans

5

IPR009954

9,954

Protein of unknown function DUF1482

DUF1482

Family

1,207

false

This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07358" ]

[ "DUF1482" ]

[ 1207 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Podoviridae sp. ct3k57", "bioreactor metagenome" ]

[ 1205, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1482

DUF1482

1

IPR009955

9,955

Liver-expressed antimicrobial peptide 2

LEAP-2

Family

934

false

This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core structure with two disulphide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesised as a 77-residue precursor...

[ "GO:0042742" ]

[ "defense response to bacterium" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07359", "PTHR21007" ]

[ "LEAP-2", "" ]

[ 931, 924 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803157", "R-HSA-6803157", "R-MMU-6803157" ]

[ "REACTOME:R-BTA-6803157", "REACTOME:R-HSA-6803157", "REACTOME:R-MMU-6803157" ]

3

[ "2l1q" ]

1

[ "PUB00013114" ]

[ "12493837" ]

[ "Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver." ]

[ 2003 ]

1

[]

0

null

[ "Vertebrata" ]

[ 934 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 1, 3 ]

4

true

Family

Liver-expressed antimicrobial peptide 2

LEAP-2

4

IPR009957

9,957

Protein of unknown function DUF1484

DUF1484

Family

325

false

This family consists of several hypothetical bacterial proteins of around 110 residues in length. Members of this family appear to be found in Ralstonia solanacearum and related betaproteobacteria. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07363" ]

[ "DUF1484" ]

[ 325 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Zea mays", "marine sediment metagenome" ]

[ 323, 1, 1 ]

3

[ "Zea mays" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1484

DUF1484

1

IPR009958

9,958

Conotoxin, alpha-type

Conotoxin_a-typ

Family

580

false

This family consists of several alpha-conotoxin precursor proteins from a number of Conus species. Cone snail toxins, conotoxins, are small peptides with disulphide connectivity that target ion channels or G-protein-coupled receptors. Based on the number and pattern of disulphide bonds and biological activities, conoto...

[ "GO:0030550", "GO:0005576" ]

[ "acetylcholine receptor inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07365" ]

[ "Toxin_8" ]

[ 580 ]

1

[ "PROSITEDOC" ]

[ "PDOC60004" ]

[ "PROSITEDOC:PDOC60004" ]

1

[ "1mtq", "2gcz", "2md6", "5jme", "5t90", "5ug3", "5ug5", "7lqr", "7n43" ]

9

[ "PUB00013117", "PUB00016617", "PUB00016622", "PUB00017022", "PUB00096643", "PUB00097914" ]

[ "3196703", "11478951", "10988292", "1390774", "28238803", "33610632" ]

[ "Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI.", "Cone venom--from accidental stings to deliberate injection.", "lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.", "Novel al...

[ 1988, 2001, 2000, 1992, 2017, 2021 ]

6

[]

0

null

[ "Conoidea", "Microbacterium laevaniformans" ]

[ 579, 1 ]

2

[]

0

true

Family

Conotoxin, alpha-type

Conotoxin_a-typ

4

IPR009959

9,959

Polyketide cyclase SnoaL-like

Cyclase_SnoaL-like

Family

24,380

false

Polyketides form a diverse group of compounds produced mainly by microorganisms and plants. This family of polyketide synthases includes aklanonic acid methyl ester cyclases, involved in the synthesis of aklavinone, an intermediate in the biosynthetic pathway of clinically important anthracyclines such as daunorubicin ...

[ "GO:0030638" ]

[ "polyketide metabolic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07366", "PTHR38436" ]

[ "SnoaL", "" ]

[ 18232, 19526 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "5.5.1.23", "PWY-7352", "PWY-7354" ]

[ "EC:5.5.1.23", "METACYC:PWY-7352", "METACYC:PWY-7354" ]

3

[ "1sjw", "2f98", "2f99", "2gex", "2gey", "3ehc", "3f9s", "3g0k", "3g8z", "3k0z", "3kkg", "4lgq", "5x7l", "6hnl", "6hnm", "6hnn", "8kaa", "8r20", "8r2b", "8r2e", "8ysb" ]

21

[ "PUB00021066", "PUB00086899", "PUB00086900" ]

[ "15071504", "10200167", "7836284" ]

[ "Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.", "DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme.", "Analysis of clustered genes encoding both early and late steps in daunomycin biosynt...

[ 2004, 1999, 1995 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 547, 19397, 4199, 1, 14, 222 ]

6

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Polyketide cyclase SnoaL-like

Cyclase_SnoaL-like

1

IPR009960

9,960

Fungal fruit body lectin

Fruit_body_lectin_fun

Family

565

false

This family consists of several fungal fruit body lectin proteins. Fruit body lectins are thought to have insecticidal activity [ ] and may also function in capturing nematodes [ ]. One member of this family, the lectin XCL from Xerocomus chrysenteron, induces drastic changes in the actin cytoskeleton after sugar bindi...

[]

0

[ "PFAM" ]

[ "PF07367" ]

[ "FB_lectin" ]

[ 565 ]

1

[]

0

[ "1x99", "1xi0", "1y2t", "1y2u", "1y2v", "1y2w", "1y2x", "2ofc", "2ofd", "2ofe", "3qds", "3qdt", "3qdu", "3qdv", "3qdw", "3qdx", "3qdy", "4yld", "4z2f", "4z2q", "4z2s" ]

21

[ "PUB00013118", "PUB00013454", "PUB00032353" ]

[ "12450118", "12787928", "15561152" ]

[ "Two genes encoding fruit body lectins of Pleurotus cornucopiae: sequence similarity with the lectin of a nematode-trapping fungus.", "Xerocomus chrysenteron lectin: identification of a new pesticidal protein.", "A new lectin family with structure similarity to actinoporins revealed by the crystal structure of ...

[ 2002, 2003, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 565 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Fungal fruit body lectin

Fruit_body_lectin_fun

6

IPR009961

9,961

Protein of unknown function DUF1487

DUF1487

Family

274

false

This family consists of several uncharacterised proteins from Drosophila melanogaster. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07368", "PTHR21644" ]

[ "DUF1487", "" ]

[ 269, 259 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Proteus mirabilis", "Protostomia" ]

[ 1, 273 ]

2

[ "Drosophila melanogaster" ]

[ 21 ]

1

true

Family

Protein of unknown function DUF1487

DUF1487

1