LiteFold/InterPro · Datasets at Hugging Face

IPR009962

9,962

Protein of unknown function DUF1488

DUF1488

Family

4,629

false

This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07369" ]

[ "DUF1488" ]

[ 4629 ]

1

[]

0

[ "2gpi" ]

1

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 4617, 12 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1488

DUF1488

8

IPR009963

9,963

Protein of unknown function DUF1490

DUF1490

Family

637

false

DUF1490 consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07371" ]

[ "DUF1490" ]

[ 637 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 636, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF1490

DUF1490

3

IPR009966

9,966

Prosystemin/Systemin

Family

24

false

This family consists of several plant specific Systemin and Prosystemin proteins. Systemin is processed from a larger prohormone protein, called prosystemin, by proteolytic cleavages [ ]. Systemin activates a lipid-based signal transduction pathway in which linolenic acid is converted to jasmonic acid, a potent activat...

[]

0

[ "PFAM" ]

[ "PF07376" ]

[ "Prosystemin" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00066862" ]

[ "10708853" ]

[ "The systemin signaling pathway: differential activation of plant defensive genes." ]

[ 2000 ]

1

[]

0

null

[ "Pentapetalae" ]

[ 24 ]

1

[]

0

true

Family

Prosystemin/Systemin

7

IPR009967

9,967

Flagellum biosynthesis repressor FlbT

Flagellum_FlbT

Family

2,326

false

This family consists of several FlbT proteins. FlbT is a post-transcriptional repressor function in flagellum biogenesis. FlbT is associated with the 5' untranslated region (UTR) of fljK (25kDa flagellin) mRNA and that this association requires a predicted loop structure in the transcript. Mutations within this loop ab...

[ "GO:0048027", "GO:0006402", "GO:1902209" ]

[ "mRNA 5'-UTR binding", "mRNA catabolic process", "negative regulation of bacterial-type flagellum assembly" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00783", "PF07378", "PIRSF009533" ]

[ "FlbT", "FlbT", "FlbT" ]

[ 588, 2326, 879 ]

3

[]

0

[]

0

[ "PUB00013122" ]

[ "11029689" ]

[ "FlbT, the post-transcriptional regulator of flagellin synthesis in Caulobacter crescentus, interacts with the 5' untranslated region of flagellin mRNA." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Effrenium voratum", "metagenomes" ]

[ 2303, 1, 22 ]

3

[]

0

true

Family

Flagellum biosynthesis repressor FlbT

Flagellum_FlbT

1

IPR009968

9,968

Protein of unknown function DUF1494

DUF1494

Family

32

false

This family consists of several bacterial proteins of around 175 residues in length. Members of this family seem to be found exclusively in Chlamydia species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07379" ]

[ "DUF1494" ]

[ 32 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 32 ]

1

[]

0

true

Family

Protein of unknown function DUF1494

DUF1494

5

IPR009969

9,969

Pneumovirus M2-2

Pneumo_M2-2

Family

452

false

This family consists of several Pneumovirus M2-2 proteins. The M2-2 protein acts as a regulatory factor that mediates the switch from transcription to RNA replication [ ]. It acts late in infection in which it inhibits viral transcription and up-regulates RNA replication [ , ], mediated by phosphorylation of the P prot...

[]

0

[ "PFAM" ]

[ "PF07380" ]

[ "Pneumo_M2" ]

[ 452 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9828642", "R-HSA-9828721", "R-HSA-9834752" ]

[ "REACTOME:R-HSA-9828642", "REACTOME:R-HSA-9828721", "REACTOME:R-HSA-9834752" ]

3

[]

0

[ "PUB00095618", "PUB00095620", "PUB00095621" ]

[ "15890897", "26474524", "16254330" ]

[ "Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity.", "Phosphorylation of the human respiratory syncytial virus P protein mediates M2-2 regulation of viral RNA synthesis, a process that involves two P proteins.", "Overexpression o...

[ 2005, 2016, 2005 ]

3

[]

0

null

[ "Orthopneumovirus" ]

[ 452 ]

1

[]

0

true

Family

Pneumovirus M2-2

Pneumo_M2-2

4

IPR009970

9,970

Histone H1-like nucleoprotein HC2

HC2

Family

1,842

false

This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles [ ].

[ "GO:0003677", "GO:0030527", "GO:0030261" ]

[ "DNA binding", "structural constituent of chromatin", "chromosome condensation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF07382" ]

[ "HC2" ]

[ 1842 ]

1

[]

0

[]

0

[ "PUB00013123" ]

[ "8733229" ]

[ "Purification of recombinant Chlamydia trachomatis histone H1-like protein Hc2, and comparative functional analysis of Hc2 and Hc1." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrosopumilus adriaticus", "Viruses", "metagenomes" ]

[ 1534, 244, 1, 3, 60 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Histone H1-like nucleoprotein HC2

HC2

8

IPR009971

9,971

Protein of unknown function DUF1496

DUF1496

Family

1,520

false

This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07383" ]

[ "DUF1496" ]

[ 1520 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1512, 5, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1496

DUF1496

7

IPR009972

9,972

Protein of unknown function DUF1497

DUF1497

Family

38

false

This entry represents a family of several short phage and bacterial proteins whose function is not known. This family seems to be found exclusively in Lactococcus lactis and the bacteriophages that infect this organism.

[]

0

[ "PFAM" ]

[ "PF07384" ]

[ "DUF1497" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Lactococcus", "Viruses" ]

[ 27, 11 ]

2

[]

0

true

Family

Protein of unknown function DUF1497

DUF1497

3

IPR009973

9,973

Seadornavirus VP7

Seadorna_VP7

Family

51

false

This family consists of several Seadornavirus specific VP7 proteins of around 305 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07387" ]

[ "Seadorna_VP7" ]

[ 51 ]

1

[ "GP" ]

[ "GenProp1016" ]

[ "GP:GenProp1016" ]

1

[]

0

[]

0

[]

0

null

[ "Cylindrospermopsis curvispora GIHE-G1", "Fungi", "Viruses", "viral metagenome" ]

[ 1, 16, 30, 4 ]

4

[]

0

true

Family

Seadornavirus VP7

Seadorna_VP7

4

IPR009974

9,974

Vaccinia virus, B6

Vaccinia_virus_B6

Family

79

false

This family consists of several Orthopoxvirus specific proteins, which include Vaccinia virus, B6 protein, also known as Protein OPG191. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07389" ]

[ "Pox_B6" ]

[ 79 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chordopoxvirinae" ]

[ 79 ]

1

[]

0

true

Family

Vaccinia virus, B6

Vaccinia_virus_B6

9

IPR009975

9,975

Mycoplasma P30

P30

Family

41

false

This family consists of several P30 proteins which seem to be specific to Mycoplasma agalactiae. P30 is a 30kDa immunodominant antigen and is known to be a transmembrane protein [ ].

[]

0

[ "PFAM" ]

[ "PF07390" ]

[ "P30" ]

[ 41 ]

1

[]

0

[]

0

[ "PUB00013125" ]

[ "11473997" ]

[ "Characterization and analysis of a stable serotype-associated membrane protein (P30) of Mycoplasma agalactiae." ]

[ 2001 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 41 ]

1

[]

0

true

Family

Mycoplasma P30

P30

2

IPR009976

9,976

Exocyst complex component Sec10-like

Sec10-like

Family

7,135

false

This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for membrane fusion [ , , ]. It is also involved in cell polarisation, primary...

[ "GO:0005737" ]

[ "cytoplasm" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR12100" ]

[ "" ]

[ 7135 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-264876", "R-CEL-5620916", "R-DDI-264876", "R-DME-264876", "R-DME-5620916", "R-HSA-1445148", "R-HSA-264876", "R-HSA-5620916", "R-MMU-264876", "R-MMU-5620916", "R-RNO-264876", "R-RNO-5620916" ]

[ "REACTOME:R-CEL-264876", "REACTOME:R-CEL-5620916", "REACTOME:R-DDI-264876", "REACTOME:R-DME-264876", "REACTOME:R-DME-5620916", "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-5620916", "REACTOME:R-MMU-264876", "REACTOME:R-MMU-5620916", "REACTOME:R-RNO-264876", "REACTOME:R-RN...

12

[ "5h11", "5yfp", "6vkl" ]

3

[ "PUB00013127", "PUB00059255", "PUB00059256", "PUB00059257", "PUB00100040", "PUB00100048" ]

[ "12665531", "10769031", "11287615", "12511573", "28098232", "29335562" ]

[ "The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum.", "The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae.", "Skp1p and the F-box protein Rcy1p form a non-SCF complex invol...

[ 2003, 2000, 2001, 2003, 2017, 2018 ]

6

[]

0

null

[ "Eukaryota" ]

[ 7135 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 3, 6, 4, 2, 4, 4, 2, 2, 7 ]

12

true

Family

Exocyst complex component Sec10-like

Sec10-like

4

IPR009977

9,977

Mig-14

Family

1,771

false

This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood [ ].

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF011840", "PF07395", "PIRSF029703" ]

[ "PRK15312.1", "Mig-14", "Mig-14" ]

[ 595, 1771, 1356 ]

3

[]

0

[]

0

[ "PUB00013128" ]

[ "12029036" ]

[ "mig-14 is a Salmonella gene that plays a role in bacterial resistance to antimicrobial peptides." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Diploscapter pachys" ]

[ 1770, 1 ]

2

[]

0

true

Family

Mig-14

6

IPR009978

9,978

Putative Na+/H+ antiporter

Na_H_antiport_3

Family

978

false

This family consists of several hypothetical bacterial proteins of around 440 residues in length. The function of this family is unknown. Many members carry 11 or 12 transmembrane regions, suggesting that they might be transporters. One family member, is classified by TCDB as being an NhaE type of Na+/H+ antiporter.

[]

0

[ "PFAM" ]

[ "PF07399" ]

[ "Na_H_antiport_3" ]

[ 978 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 955, 2, 21 ]

3

[]

0

true

Family

Putative Na+/H+ antiporter

Na_H_antiport_3

4

IPR009979

9,979

Bovine Lentivirus VIF

Lenti_VIF_2

Family

72

false

This family consists of several Lentivirus viral infectivity factor (VIF) proteins. VIF is known to be essential for ability of cell-free virus preparation to infect cells [ ]. Members of this family are specific to Bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) which also infects cattle.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07401", "PIRSF003854" ]

[ "Lenti_VIF_2", "Lenti_VIF_2" ]

[ 72, 2 ]

2

[]

0

[ "7upn" ]

1

[ "PUB00013132" ]

[ "9440006" ]

[ "Sequence data analysis reveals a relationship between LSR2, the recombinant fusion protein mimicing M.Leprae and VIF of bovine immunodeficiency virus (BIV)." ]

[ 1997 ]

1

[]

0

null

[ "Lentivirus" ]

[ 72 ]

1

[]

0

true

Family

Bovine Lentivirus VIF

Lenti_VIF_2

6

IPR009980

9,980

Human herpesvirus U26

Herpes_U26

Family

38

false

This family consists of several Human herpesvirus U26 proteins of around 300 residues in length. The function of this family is unknown.

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07402" ]

[ "Herpes_U26" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Homo sapiens", "Roseolovirus", "Salmonella enterica" ]

[ 1, 36, 1 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Human herpesvirus U26

Herpes_U26

5

IPR009981

9,981

Protein of unknown function DUF1505

DUF1505

Family

41

false

This family consists of several uncharacterised Caenorhabditis elegans proteins of around 115 resides in length. Members of this family contain 6 highly conserved cysteine residues. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07403" ]

[ "DUF1505" ]

[ 41 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 41 ]

1

[ "Caenorhabditis elegans" ]

[ 6 ]

1

true

Family

Protein of unknown function DUF1505

DUF1505

3

IPR009983

9,983

Uncharacterised protein family UPF0358

UPF0358

Family

1,815

false

This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown; however they form α-helical bundles and are thought to be involved in control of cell shape [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01560", "NF010187", "PF07408" ]

[ "UPF0358", "PRK13666.1", "DUF1507" ]

[ 1457, 1701, 1815 ]

3

[]

0

[ "2gbo", "2odm" ]

2

[ "PUB00043225" ]

[ "17469204" ]

[ "Crystal structure of S. aureus YlaN, an essential leucine rich protein involved in the control of cell shape." ]

[ 2007 ]

1

[]

0

null

[ "Bacilli", "Eukaryota", "bioreactor metagenome" ]

[ 1811, 3, 1 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0358

UPF0358

9

IPR009985

9,985

Crinivirus P26

Crinivirus_P26

Family

5

false

This family consists of several Crinivirus P26 proteins which seem to be found exclusively in the Lettuce infectious yellows virus. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07416" ]

[ "Crinivirus_P26" ]

[ 5 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Lettuce infectious yellows virus" ]

[ 5 ]

1

[]

0

true

Family

Crinivirus P26

Crinivirus_P26

1

IPR009986

9,986

Sigma factor-binding transcriptional regulator Crl

Tscrpt_reg_Crl

Family

1,583

false

This family contains the bacterial Sigma factor-binding protein Crl. This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria [ ]. These proteins bind to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes....

[ "GO:0045893" ]

[ "positive regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01178", "NF008217", "PF07417" ]

[ "Crl", "PRK10984.1", "Crl" ]

[ 1473, 1535, 1583 ]

3

[]

0

[ "2mz8", "3rpj", "4q11", "6kj6", "6omf" ]

5

[ "PUB00013139", "PUB00091054" ]

[ "1357528", "27180360" ]

[ "The Crl protein activates cryptic genes for curli formation and fibronectin binding in Escherichia coli HB101.", "Recent advances in the characterization of Crl, the unconventional activator of the stress sigma factor σS/RpoS." ]

[ 1992, 2016 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1578, 5 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sigma factor-binding transcriptional regulator Crl

Tscrpt_reg_Crl

9

IPR009987

9,987

PilM, inner membrane

IM_PilM

Family

1,101

false

This entry contains the bacterial protein PilM (approximately 150 residues long). PilM is an inner membrane protein that has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body [ ].

[]

0

[ "PFAM" ]

[ "PF07419" ]

[ "PilM" ]

[ 1101 ]

1

[]

0

[ "3eoi", "3hg9" ]

2

[ "PUB00012885" ]

[ "11751821" ]

[ "Genes required for plasmid R64 thin-pilus biogenesis: identification and localization of products of the pilK, pilM, pilO, pilP, pilR, and pilT genes." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Plasmid R64", "Pseudomonadati", "mine drainage metagenome" ]

[ 2, 1, 1094, 4 ]

4

[]

0

true

Family

PilM, inner membrane

IM_PilM

7

IPR009988

9,988

Domain of unknown function DUF1510

DUF1510

Domain

1,353

false

Proteins containing this domain consist of several hypothetical bacterial proteins of around 200 residues in length. Their function is unknown.

[]

0

[ "PFAM" ]

[ "PF07423" ]

[ "DUF1510" ]

[ 1353 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1351, 2 ]

2

[]

0

true

Domain

Domain of unknown function DUF1510

DUF1510

7

IPR009989

9,989

TrbM

Family

1,351

false

This family contains the bacterial protein TrbM (approximately 180 residues long). In Comamonas testosteroni T-2, TrbM is derived from the IncP1beta plasmid pTSA, which encodes the widespread genes for p-toluenesulphonate (TSA) degradation [ ]. This family also includes MPFK and its functional homologue kikA, which are...

[]

0

[ "PFAM" ]

[ "PF07424" ]

[ "TrbM" ]

[ 1351 ]

1

[]

0

[]

0

[ "PUB00013142", "PUB00098340" ]

[ "11282598", "31604768" ]

[ "Map of the IncP1beta plasmid pTSA encoding the widespread genes (tsa) for p-toluenesulfonate degradation in Comamonas testosteroni T-2.", "Conjugative Transfer of IncP-9 Catabolic Plasmids Requires a Previously Uncharacterized Gene, <i>mpfK</i>, Whose Homologs Are Conserved in Various MPF<sub>T</sub>-Type Plasmi...

[ 2001, 2019 ]

2

[]

0

null

[ "Bacteria", "Caenorhabditis japonica", "bioreactor metagenome", "plasmids" ]

[ 1338, 3, 1, 9 ]

4

[]

0

true

Family

TrbM

2

IPR009990

9,990

Pardaxin

Family

5

false

This family consists of several Pardaxin proteins. Pardaxin, a 33-amino-acid pore-forming polypeptide toxin isolated from the Red Sea Moses sole Pardachirus marmoratus, has a helix-hinge-helix structure. This is a common structural motif found both in antibacterial peptides that can act selectively on bacterial membran...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF07425", "PIRSF037561" ]

[ "Pardaxin", "Pardaxin" ]

[ 5, 5 ]

2

[]

0

[ "1xc0", "2kns" ]

2

[ "PUB00013143", "PUB00013144" ]

[ "8620888", "3996550" ]

[ "A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus.", "Pharyngeal cavity and the gills are the target organ for the repellent action of pardaxin in shark." ]

[ 1996, 1985 ]

2

[]

0

null

[ "Pardachirus" ]

[ 5 ]

1

[]

0

true

Family

Pardaxin

3

IPR009991

9,991

Dynactin subunit 3

DCTN3

Family

3,095

false

DCTN3 is the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localises to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis [ ].

[ "GO:0061640", "GO:0005869" ]

[ "cytoskeleton-dependent cytokinesis", "dynactin complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07426", "PTHR28360" ]

[ "Dynactin_p22", "" ]

[ 3087, 2151 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2132295", "R-BTA-2565942", "R-BTA-3371497", "R-BTA-380259", "R-BTA-380270", "R-BTA-380284", "R-BTA-380320", "R-BTA-5620912", "R-BTA-6807878", "R-BTA-6811436", "R-BTA-8854518", "R-HSA-2132295", "R-HSA-2565942", "R-HSA-3371497", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", ...

[ "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-2565942", "REACTOME:R-BTA-3371497", "REACTOME:R-BTA-380259", "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380284", "REACTOME:R-BTA-380320", "REACTOME:R-BTA-5620912", "REACTOME:R-BTA-6807878", "REACTOME:R-BTA-6811436", "REACTOME:R-BTA-8854518", "REACTOME:R-...

43

[ "6znl", "7z8f", "8ptk", "9b7j", "9dgr", "9dgs", "9dgt", "9dgu", "9dgv" ]

9

[ "PUB00013145" ]

[ "9722614" ]

[ "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells." ]

[ 1998 ]

1

[]

0

null

[ "Bacillus phage Bolokhovo", "Eukaryota", "Pseudomonadati" ]

[ 1, 3091, 3 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 6, 2, 5 ]

5

true

Family

Dynactin subunit 3

DCTN3

5

IPR009992

9,992

Acyltransferase Tri3/Sat12/Sat16/Mac1

Tri3/Sat12/Sat16/Mac1

Family

511

false

This entry includes Tri3 from Fusarium sporotrichioides [ ], Mac1 from Ustilago maydis [ ], and Sat16/Sat12 from Stachybotrys chartarum [ ]. Tri3/Sat12/Sat16 are trichothecene 15-O-acetyltransferases involved in mycotoxins biosynthesis. Mac1 is an acetyltransferase involved in the mannosylerythritol lipids (MELs) biosy...

[ "GO:0016407", "GO:0043386" ]

[ "acetyltransferase activity", "mycotoxin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07428" ]

[ "Tri3" ]

[ 511 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887" ]

[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887" ]

11

[ "3fot", "3fp0" ]

2

[ "PUB00052014", "PUB00087317", "PUB00093997" ]

[ "19319932", "25015739", "31103599" ]

[ "Structural and functional characterization of TRI3 trichothecene 15-O-acetyltransferase from Fusarium sporotrichioides.", "Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys.", "Elucidation of substrate specificities of decorating enzymes involved in...

[ 2009, 2014, 2019 ]

3

[]

0

null

[ "Dikarya" ]

[ 511 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Acyltransferase Tri3/Sat12/Sat16/Mac1

Tri3/Sat12/Sat16/Mac1

6

IPR009993

9,993

TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase

WecF

Family

2,297

false

TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase catalyses the synthesis of Fuc4NAc-ManNAcA-GlcNAc-PP-Und (lipid III) as part of the biosynthetic pathway of enterobacterial common antigen (ECA), a polysaccharide comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc [ ].

[ "GO:0008417", "GO:0009246" ]

[ "fucosyltransferase activity", "enterobacterial common antigen biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01002", "NF002753", "PF07429" ]

[ "WecF_RffT", "PRK02797.1-2", "Glyco_transf_56" ]

[ 1557, 1610, 2297 ]

3

[ "EC", "GP" ]

[ "2.4.1.325", "GenProp1270" ]

[ "EC:2.4.1.325", "GP:GenProp1270" ]

2

[]

0

[ "PUB00012908" ]

[ "11673418" ]

[ "Identification of the structural gene for the TDP-Fuc4NAc:lipid II Fuc4NAc transferase involved in synthesis of enterobacterial common antigen in Escherichia coli K-12." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 2281, 2, 4, 10 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase

WecF

3

IPR009994

9,994

Phloem filament PP1

PP1

Domain

51

false

This domain represents a conserved region approximately 200 residues long, four copies of which are found within the plant phloem filament protein PP1. This is one of the constituents of the proteinaceous filaments found in the sieve elements of Cucurbita phloem [ ].

[]

0

[ "PFAM" ]

[ "PF07430" ]

[ "PP1" ]

[ 51 ]

1

[]

0

[]

0

[ "PUB00013147" ]

[ "9263452" ]

[ "Molecular characterization of a phloem-specific gene encoding the filament protein, phloem protein 1 (PP1), from Cucurbita maxima." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota" ]

[ 51 ]

1

[]

0

true

Domain

Phloem filament PP1

PP1

4

IPR009995

9,995

Protein of unknown function DUF1512

DUF1512

Family

214

false

This family consists of several archaeal proteins of around 370 residues in length. The function of this family is unknown.

[]

0

[ "PIRSF" ]

[ "PIRSF016495" ]

[ "UCP016495" ]

[ 214 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 207, 7 ]

2

[]

0

true

Family

Protein of unknown function DUF1512

DUF1512

6

IPR009996

9,996

Regulatory protein YycH

YycH

Domain

2,663

false

The YycFG two-component system is the only signal transduction system in Bacillus subtilis known to be essential for cell viability. This system is highly conserved in low-G+C Gram-positive bacteria, regulating important processes such as cell wall homeostasis, cell membrane integrity, and cell division. Four other gen...

[]

0

[ "PFAM" ]

[ "PF07435" ]

[ "YycH" ]

[ 2663 ]

1

[]

0

[ "2fgt" ]

1

[ "PUB00021076", "PUB00040661", "PUB00042101", "PUB00045177" ]

[ "16030236", "16600972", "17307848", "17307850" ]

[ "YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.", "The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.", "The crystal structure of Bacillus subtilis YycI revea...

[ 2005, 2006, 2007, 2007 ]

4

[]

0

null

[ "Bacteria", "Trichuris trichiura", "bioreactor metagenome" ]

[ 2661, 1, 1 ]

3

[]

0

true

Domain

Regulatory protein YycH

YycH

7

IPR009998

9,998

YfaZ

Family

2,134

false

This family contains the precursor of the bacterial protein YfaZ (approximately 180 residues long). Many members of this family are hypothetical proteins.

[]

0

[ "PFAM" ]

[ "PF07437" ]

[ "YfaZ" ]

[ 2134 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 2099, 4, 30, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YfaZ

2

IPR009999

9,999

Protein of unknown function DUF1514

DUF1514

Family

171

false

This entry includes Bacteriophage phi PVL, Orf60. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several Staphylococcus aureus and related bacteriophage proteins of around 65 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07438" ]

[ "DUF1514" ]

[ 171 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Viruses" ]

[ 101, 70 ]

2

[]

0

true

Family

Protein of unknown function DUF1514

DUF1514

7

IPR010000

10,000

Caerin 1

Caerin_1

Domain

28

false

This entry consists of several caerin 1 proteins from Litoria species, Australian tree frogs. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides [ ]. These peptides are excreted from amphibian skin, and can interact with and disrupt bacterial membranes, leading to the ...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07440" ]

[ "Caerin_1" ]

[ 28 ]

1

[]

0

[]

0

[ "PUB00013151", "PUB00094036" ]

[ "12717721", "12709067" ]

[ "The solution structures and activity of caerin 1.1 and caerin 1.4 in aqueous trifluoroethanol and dodecylphosphocholine micelles.", "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain...

[ 2003, 2003 ]

2

[]

0

null

[ "Pelodryadinae" ]

[ 28 ]

1

[]

0

true

Domain

Caerin 1

Caerin_1

5

IPR010001

10,001

SigmaK-factor processing regulatory BofA

BofA

Family

2,667

false

This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Follow...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07441", "TIGR02862" ]

[ "BofA", "spore_BofA" ]

[ 2667, 1351 ]

2

[]

0

[]

0

[ "PUB00013152" ]

[ "10464210" ]

[ "Role of the sporulation protein BofA in regulating activation of the Bacillus subtilis developmental transcription factor sigmaK." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 317, 2324, 26 ]

3

[]

0

true

Family

SigmaK-factor processing regulatory BofA

BofA

2

IPR010002

10,002

Poneritoxin

Family

13

false

This family contains a number of Poneritoxin (also known as ponericin) peptides (approximately 30 residues long) from the venom of the predatory ant Pachycondyla goeldii (Ponerine ant). These peptides exhibit antibacterial and insecticidal properties, and may adopt an amphipathic α-helical structure in polar environmen...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07442" ]

[ "Ponericin" ]

[ 13 ]

1

[]

0

[]

0

[ "PUB00013153" ]

[ "11279030" ]

[ "Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii." ]

[ 2001 ]

1

[]

0

null

[ "Ponerini" ]

[ 13 ]

1

[]

0

true

Family

Poneritoxin

2

IPR010004

10,004

Uncharacterised protein family Ycf66

Uncharacterised_Ycf66

Family

1,183

false

This entry represents Ycf66, a protein that is restricted to the chloroplasts of simple plants and algae. It is also found in the cyanobacteria. The function is unknown. As the family is exclusively found in phototrophic organisms it may play a role in photosynthesis.

[]

0

[ "PFAM" ]

[ "PF07444" ]

[ "Ycf66_N" ]

[ 1183 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Natronoglomus mannanivorans", "marine metagenome" ]

[ 727, 454, 1, 1 ]

4

[]

0

true

Family

Uncharacterised protein family Ycf66

Uncharacterised_Ycf66

2

IPR010005

10,005

Formate hydrogenlyase maturation HycH

Formate_DH_maturation_HycH

Family

1,384

false

This family contains the bacterial formate hydrogenlyase maturation protein HycH, which is approximately 140 residues long. This may be required for the conversion of a precursor form of the large subunit of hydrogenlyase 3 into a mature form [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011664", "PF07450" ]

[ "PRK15084.1", "HycH" ]

[ 1269, 1384 ]

2

[]

0

[]

0

[ "PUB00013159" ]

[ "1625581" ]

[ "Mutational analysis of the operon (hyc) determining hydrogenase 3 formation in Escherichia coli." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "metagenomes" ]

[ 1380, 1, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Formate hydrogenlyase maturation HycH

Formate_DH_maturation_HycH

1

IPR010006

10,006

Bacteriophage P4, Psu, polarity suppression protein

Phage_P4_Psu

Family

1,025

false

This family contains a number of phage polarity suppression proteins (Psu) (approximately 190 residues long). The Psu protein of Bacteriophage P4 causes suppression of transcriptional polarity in Escherichia coli by overcoming Rho termination factor activity [ ]. It has the structure of a golf stick composed of seven h...

[]

0

[ "PFAM" ]

[ "PF07455" ]

[ "Psu" ]

[ 1025 ]

1

[]

0

[ "3rx6", "4dvd", "8peu", "8pew", "8pex", "8pey", "9gcs", "9gct" ]

8

[ "PUB00013162", "PUB00097466" ]

[ "9007066", "23150672" ]

[ "In vivo and in vitro evidence for an anti-Rho activity induced by the phage P4 polarity suppressor protein Psu.", "The first structure of polarity suppression protein, Psu from enterobacteria phage P4, reveals a novel fold and a knotted dimer." ]

[ 1997, 2012 ]

2

[]

0

null

[ "Bacteria", "human gut metagenome", "unclassified Caudoviricetes" ]

[ 1020, 3, 2 ]

3

[]

0

true

Family

Bacteriophage P4, Psu, polarity suppression protein

Phage_P4_Psu

8

IPR010007

10,007

SPAN-X family

SPAN-X_fam

Family

200

false

This entry represents SPAN-X (Sperm Protein Associated with the Nucleus on the X chromosome) family proteins, including N1, N2, N3 and N5. These human sperm proteins are associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTA...

[]

0

[ "PFAM" ]

[ "PF07458" ]

[ "SPAN-X" ]

[ 200 ]

1

[]

0

[]

0

[ "PUB00013163" ]

[ "11133693" ]

[ "Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa." ]

[ 2001 ]

1

[]

0

null

[ "Boreoeutheria" ]

[ 200 ]

1

[ "Homo sapiens" ]

[ 27 ]

1

true

Family

SPAN-X family

SPAN-X_fam

6

IPR010008

10,008

Vibrio phage CTX, RstB

Vibrio_Phage_CTX_RstB

Family

133

false

This family contains a number of RstB proteins approximately 120 residues long, including RstB1 and RstB2, from the Vibrio cholerae phage CTX. Functional analyses indicate that rstB2 is required for integration of the CTXphi phage into the V. cholerae chromosome [ ].

[]

0

[ "PFAM" ]

[ "PF07459" ]

[ "CTX_RstB" ]

[ 133 ]

1

[]

0

[]

0

[ "PUB00013164" ]

[ "9220000" ]

[ "Regulation, replication, and integration functions of the Vibrio cholerae CTXphi are encoded by region RS2." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Entamoeba histolytica HM-1:IMSS-B", "Viruses", "marine sediment metagenome" ]

[ 113, 1, 18, 1 ]

4

[]

0

true

Family

Vibrio phage CTX, RstB

Vibrio_Phage_CTX_RstB

2

IPR010009

10,009

Apolipophorin-III

ApoLp-III

Family

313

false

This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insec...

[ "GO:0008289", "GO:0006869", "GO:0005576" ]

[ "lipid binding", "lipid transport", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07464" ]

[ "ApoLp-III" ]

[ 313 ]

1

[]

0

[ "1eq1" ]

1

[ "PUB00013168" ]

[ "11818551" ]

[ "Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 14, 299 ]

2

[]

0

true

Family

Apolipophorin-III

ApoLp-III

8

IPR010010

10,010

Photosystem I PsaM, reaction centre

PSI_PsaM

Family

1,581

false

Members of this protein family are PsaM, which is subunit XII of the photosystem I reaction centre. PsaM forms part of the photosystem I complex and its binding is stabilised by PsaI [ ]. This protein is found in both the Cyanobacteria and the chloroplasts of plants, but is absent from non-oxygenic photosynthetic bacte...

[ "GO:0015979" ]

[ "photosynthesis" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00828", "PF07465", "TIGR03053" ]

[ "PSI_PsaM", "PsaM", "PS_I_psaM" ]

[ 1512, 1530, 1574 ]

3

[ "GP" ]

[ "GenProp0660" ]

[ "GP:GenProp0660" ]

1

[ "1jb0", "3pcq", "4fe1", "4kt0", "4l6v", "5oy0", "5zf0", "5zgb", "5zgh", "6fos", "6hqb", "6igz", "6jeo", "6k33", "6k61", "6kif", "6kig", "6kmw", "6kmx", "6l35", "6l4u", "6lu1", "6ly5", "6nwa", "6pfy", "6pgk", "6pnj", "6tcl", "6tra", "6trc", "6trd", "6uzv"...

87

[ "PUB00013169" ]

[ "8787020" ]

[ "Characterization of psaI and psaL mutants of Synechococcus sp. strain PCC 7002: a new model for state transitions in cyanobacteria." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 322, 1259 ]

2

[]

0

true

Family

Photosystem I PsaM, reaction centre

PSI_PsaM

1

IPR010011

10,011

Nuclear receptor coactivator, DUF1518

NCO_DUF1518

Domain

4,192

false

This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3), also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [ , ]. NCOA1 directly binds nuclear receptors and stimulates the transcrip...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "SMART" ]

[ "PF07469", "SM01151" ]

[ "DUF1518", "DUF1518" ]

[ 3074, 4171 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-159418", "R-DRE-3214847", "R-DRE-400206", "R-DRE-5625886", "R-DRE-9707564", "R-HSA-1368108", "R-HSA-159418", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-1989781", "R-HSA-211976", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-3214847", "R-HSA-381340", "R-HSA-3899300", "...

[ "REACTOME:R-DRE-159418", "REACTOME:R-DRE-3214847", "REACTOME:R-DRE-400206", "REACTOME:R-DRE-5625886", "REACTOME:R-DRE-9707564", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-192105", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-193807", "REACTOME:R-HSA-1989781", "REACTOME:R-HS...

63

[]

0

[ "PUB00046527", "PUB00069370", "PUB00069371", "PUB00069373", "PUB00069375", "PUB00069376", "PUB00069378", "PUB00069379", "PUB00069383", "PUB00069384", "PUB00069386", "PUB00097822" ]

[ "12138096", "10823921", "9427757", "10713439", "12954634", "11773079", "10449719", "12529333", "12507421", "9430642", "23226788", "21854393" ]

[ "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.", "The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.", "Isoforms of steroid receptor co-activator 1...

[ 2002, 2000, 1998, 2000, 2003, 2002, 1999, 2003, 2002, 1998, 2012, 2011 ]

12

[]

0

null

[ "Vertebrata" ]

[ 4192 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 14, 13, 14 ]

4

true

Domain

Nuclear receptor coactivator, DUF1518

NCO_DUF1518

8

IPR010012

10,012

Spasmodic peptide gm9a

Toxin_11

Family

7

false

This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the 'spasmodic peptide', tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile [ ]. Upon injection of this venom co...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07473" ]

[ "Toxin_11" ]

[ 7 ]

1

[]

0

[ "1ixt", "2mso" ]

2

[ "PUB00010514", "PUB00013174" ]

[ "12193600", "10677206" ]

[ "Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.", "The spasmodic peptide defines a new conotoxin superfamily." ]

[ 2002, 2000 ]

2

[]

0

null

[ "Conus" ]

[ 7 ]

1

[]

0

true

Family

Spasmodic peptide gm9a

Toxin_11

5

IPR010014

10,014

Diphthamide synthesis DHP2

DHP2

Family

3,330

false

DPH2, also known as diphthamide biosynthesis protein 2 or 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, has been shown in Saccharomyces cerevisiae (Baker's yeast) to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide [ ]. This m...

[ "GO:0017183" ]

[ "protein histidyl modification to diphthamide" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR00272" ]

[ "DPH2" ]

[ 3330 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5358493", "R-DDI-5358493", "R-DRE-5358493", "R-HSA-5358493", "R-MMU-5358493", "R-SCE-5358493", "R-SPO-5358493" ]

[ "REACTOME:R-CEL-5358493", "REACTOME:R-DDI-5358493", "REACTOME:R-DRE-5358493", "REACTOME:R-HSA-5358493", "REACTOME:R-MMU-5358493", "REACTOME:R-SCE-5358493", "REACTOME:R-SPO-5358493" ]

7

[]

0

[ "PUB00005715", "PUB00017070" ]

[ "8406038", "15485916" ]

[ "Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.", "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2." ]

[ 1993, 2004 ]

2

[ "IPR016435" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3330 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 4, 1, 1, 1, 2, 1, 1, 2, 1, 1 ]

10

true

Family

Diphthamide synthesis DHP2

DHP2

2

IPR010017

10,017

tRNA U34 carboxymethyltransferase

CmoB

Family

4,717

false

This family represents tRNA U34 carboxymethyltransferase CmoB. CmoA and CmoB are important components of the cmo5U biosynthetic pathway. These enzymes are involved in the conversion of 5-hydroxyuridine (ho5U) to uridine-5-oxyacetic acid (cmo5U) at the wobble position (34) of tRNA [ ]. Uridine-5-oxyacetic acid at tRNA p...

[ "GO:0016765", "GO:0002098" ]

[ "transferase activity, transferring alkyl or aryl (other than methyl) groups", "tRNA wobble uridine modification" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01590", "TIGR00452" ]

[ "tRNA_carboxymethyltr_CmoB", "" ]

[ 4640, 4711 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METAC...

[ "2.5.1.-", "GenProp1077", "GenProp1340", "PWY-4502", "PWY-4681", "PWY-5802", "PWY-5815", "PWY-5816", "PWY-5817", "PWY-5893", "PWY-5979", "PWY-6262", "PWY-6403", "PWY-6659", "PWY-6681", "PWY-6936", "PWY-7372", "PWY-7405", "PWY-7407", "PWY-7493", "PWY-7520", "PWY-7529", "PW...

[ "EC:2.5.1.-", "GP:GenProp1077", "GP:GenProp1340", "METACYC:PWY-4502", "METACYC:PWY-4681", "METACYC:PWY-5802", "METACYC:PWY-5815", "METACYC:PWY-5816", "METACYC:PWY-5817", "METACYC:PWY-5893", "METACYC:PWY-5979", "METACYC:PWY-6262", "METACYC:PWY-6403", "METACYC:PWY-6659", "METACYC:PWY-6681"...

45

[ "4p7c", "4qnu", "4qnv", "4qnx", "7ct8", "7ct9", "7cta" ]

7

[ "PUB00043575", "PUB00043576", "PUB00079211" ]

[ "15383682", "17942742", "23676670" ]

[ "The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo.", "The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons.", "Structure-guided discovery of the metabolite carboxy-SAM that modulates tR...

[ 2004, 2007, 2013 ]

3

[ "IPR027555" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4647, 5, 65 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

tRNA U34 carboxymethyltransferase

CmoB

2

IPR010020

10,020

Integral membrane protein, YccS/YhfK

Integral_membrane_YCCS_YHJK

Family

5,179

false

This entry identifies a clade of sequences from gamma and beta proteobacteria. These proteins are more than 700 amino acids long and many have been annotated as putative membrane proteins. The gene from Salmonella has been annotated as a putative efflux transporter. The gene from Escherichia coli has been annotated as ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01667" ]

[ "YCCS_YHFK" ]

[ 5179 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR010019" ]

0

1

0

[ "Bacteria", "leotiomyceta", "metagenomes" ]

[ 5175, 2, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Integral membrane protein, YccS/YhfK

Integral_membrane_YCCS_YHJK

9

IPR010021

10,021

Phosphatidylglycerophosphate phosphatase

PGPP1/Gep4

Family

6,796

false

This group of proteins is a part of the IIIA subfamily of the haloacid dehalogenase (HAD) superfamily of hydrolases. All characterised members of this subfamily and most characterised members of the HAD superfamily are phosphatases. HAD superfamily phosphatases contain active site residues in several conserved catalyti...

[ "GO:0008962" ]

[ "phosphatidylglycerophosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01668" ]

[ "YqeG_hyp_ppase" ]

[ 6796 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.3.27", "PWY-5269", "PWY-5668", "PWY-7817" ]

[ "EC:3.1.3.27", "METACYC:PWY-5269", "METACYC:PWY-5668", "METACYC:PWY-7817" ]

4

[]

0

[ "PUB00003337", "PUB00066452", "PUB00066888", "PUB00094223" ]

[ "7966317", "20485265", "19221197", "25910650" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4.", "The genetic interactome of prohib...

[ 1994, 2010, 2009, 2015 ]

4

[]

[ "IPR027706" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4869, 1902, 25 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 4, 1, 3, 1, 5 ]

5

true

Family

Phosphatidylglycerophosphate phosphatase

PGPP1/Gep4

9

IPR010022

10,022

Protein of unknown function XkdX

XkdX

Family

1,528

false

This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09693", "TIGR01669" ]

[ "Phage_XkdX", "phage_XkdX" ]

[ 1488, 827 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "bioreactor metagenome" ]

[ 1297, 223, 8 ]

3

[]

0

true

Family

Protein of unknown function XkdX

XkdX

7

IPR010023

10,023

KdsC family

KdsC_fam

Family

12,516

false

This entry is a part of the haloacid dehalogenase (HAD) superfamily of hydrolases, mainly from beta, gamma and epsilon proteobacteria, Aquifex, Fusobacterium, Porphyromonas and Methanosarcina. All characterised members of the HAD-superfamily hydrolase, subfamily IIIA and most characterised members of the HAD superfamil...

[ "GO:0016788" ]

[ "hydrolase activity, acting on ester bonds" ]

[ "molecular_function" ]

1

[ "PIRSF", "SFLD", "NCBIFAM" ]

[ "PIRSF006118", "SFLDG01138", "TIGR01670" ]

[ "KDO8-P_Ptase", "C1.6.2:_Deoxy-d-mannose-octulo", "KdsC-phosphatas" ]

[ 10482, 12351, 10953 ]

3

[ "EC", "GP", "METACYC", "METACYC" ]

[ "3.1.3.45", "GenProp0204", "PWY-1269", "PWY-7674" ]

[ "EC:3.1.3.45", "GP:GenProp0204", "METACYC:PWY-1269", "METACYC:PWY-7674" ]

4

[ "1j8d", "1k1e", "2p9j", "2r8e", "2r8x", "2r8y", "2r8z", "3e81", "3e84", "3e8m", "3hyc", "3i6b", "3ij5", "3mmz", "3mn1", "3n07", "3n1u", "3nrj", "4hgn", "4hgo", "4hgp", "4hgq", "4hgr", "4nav", "4um5", "4um7", "4umd", "4ume", "4umf", "7t35" ]

30

[ "PUB00003337", "PUB00015003", "PUB00028127", "PUB00051616", "PUB00088395" ]

[ "7966317", "11835514", "12639950", "18986982", "23848398" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase.", "Escherichia coli YrbI is 3-deoxy-D-man...

[ 1994, 2002, 2003, 2009, 2013 ]

5

[]

[ "IPR014098" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 27, 12217, 23, 5, 244 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

KdsC family

KdsC_fam

7

IPR010024

10,024

Conserved hypothetical protein CHP1671

CHP16711

Family

1,468

false

This entry represents an uncharacterised, well-conserved family of proteins found in bacteriophage and prophage regions of mainly Gram-positive bacteria.

[]

0

[ "NCBIFAM" ]

[ "TIGR01671" ]

[ "phage_TIGR01671" ]

[ 1468 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2ox7", "2p84", "2qyz" ]

3

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Opisthokonta", "Viruses", "metagenomes" ]

[ 1134, 2, 2, 265, 65 ]

5

[]

0

true

Family

Conserved hypothetical protein CHP1671

CHP16711

6

IPR010025

10,025

HAD-superfamily phosphatase, subfamily IIIB, AphA

HAD-SF_ppase_IIIB_AphA

Family

1,324

false

This family of proteins is a member of the IIIB subfamily ( ) of the haloacid dehalogenase (HAD) superfamily of hydrolases. All characterised members of subfamily III and most characterised members of the HAD superfamily are phosphatases. HAD superfamily phosphatases contain active site residues in several conserved ca...

[ "GO:0003993", "GO:0030288" ]

[ "acid phosphatase activity", "outer membrane-bounded periplasmic space" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF", "SFLD", "NCBIFAM", "CDD" ]

[ "PIRSF017818", "SFLDG01127", "TIGR01672", "cd07499" ]

[ "Acid_Ptase_B", "C1.3:_Acid_Phosphatase_Like", "AphA", "HAD_CBAP" ]

[ 1134, 1270, 1314, 961 ]

4

[ "EC", "GP", "METACYC" ]

[ "3.1.3.2", "GenProp1301", "PWY-6348" ]

[ "EC:3.1.3.2", "GP:GenProp1301", "METACYC:PWY-6348" ]

3

[ "1n8n", "1n9k", "1rmq", "1rmt", "1rmy", "1z5g", "1z5u", "1z88", "2aut", "2b82", "2b8j", "2g1a", "2heg", "2hf7", "3cz4" ]

15

[ "PUB00003337", "PUB00013764", "PUB00013766", "PUB00014777" ]

[ "7966317", "9011040", "9760992", "14687572" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "Identification of the gene (aphA) encoding the class B acid phosphatase/phosphotransferase of Escherichia coli MG1655 and character...

[ 1994, 1997, 1998, 2004 ]

4

[ "IPR005519" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5", "metagenomes" ]

[ 1320, 1, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HAD-superfamily phosphatase, subfamily IIIB, AphA

HAD-SF_ppase_IIIB_AphA

1

IPR010026

10,026

Phage holin, LL-H family

Phage_holin_LL-H

Family

1,010

false

This entry represents a family of putative phage holins from a number of phage and prophage regions of Gram-positive bacteria. Like other holins, it is small (about 100 amino acids) with stretches of hydrophobic sequence and is encoded adjacent to lytic enzymes.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09682", "TIGR01673" ]

[ "Phage_holin_6_1", "holin_LLH" ]

[ 998, 575 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 778, 2, 214, 16 ]

4

[]

0

true

Family

Phage holin, LL-H family

Phage_holin_LL-H

1

IPR010027

10,027

Tail assembly protein G

Tail_assembly_G

Domain

1,063

false

This entry represents a domain found in the tail assembly protein G from lambda-like viruses and their prophage. In bacteriophage lambda, the overlapping open reading frames G and T are expressed by a programmed translational frameshift to produce the tail assembly proteins G and GT [ ]. Tail assembly protein GT shares...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06894", "TIGR01674" ]

[ "Phage_TAC_2", "phage_lambda_G" ]

[ 1062, 962 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00012906", "PUB00094496", "PUB00094497" ]

[ "8230192", "23911548", "23851014" ]

[ "A programmed translational frameshift is required for the synthesis of a bacteriophage lambda tail assembly protein.", "Chaperone-protein interactions that mediate assembly of the bacteriophage lambda tail to the correct length.", "A balanced ratio of proteins from gene G and frameshift-extended gene GT is req...

[ 1993, 2014, 2013 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "human gut metagenome" ]

[ 1039, 23, 1 ]

3

[]

0

true

Domain

Tail assembly protein G

Tail_assembly_G

8

IPR010028

10,028

Acid phosphatase, plant

Acid_phosphatase_pln

Family

2,868

false

This entry represents a family of acid phosphatase [ , ] from plants which are closely related to the class B non-specific acid phosphatase OlpA ( , which is believed to be a 5'-nucleotide phosphatase) and somewhat more distantly to another class B phosphatase, AphA ( ). Together these three clades define a subfamily o...

[ "GO:0003993" ]

[ "acid phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01675" ]

[ "plant-AP" ]

[ 2868 ]

1

[]

0

[ "4fyp" ]

1

[ "PUB00008422", "PUB00013754", "PUB00013762", "PUB00013775" ]

[ "1639823", "9193092", "9758760", "9747802" ]

[ "The soybean vegetative storage proteins VSP alpha and VSP beta are acid phosphatases active on polyphosphates.", "Soybean root nodule acid phosphatase.", "Purification and characterization of a soybean root nodule phosphatase expressed in Pichia pastoris.", "Arabidopsis thaliana vegetative storage protein (V...

[ 1992, 1997, 1998, 1998 ]

4

[ "IPR014403" ]

[]

1

0

1

[ "Euphyllophyta" ]

[ 2868 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 31, 15, 16 ]

3

true

Family

Acid phosphatase, plant

Acid_phosphatase_pln

4

IPR010029

10,029

Galactonolactone dehydrogenase

GL_DH

Family

742

false

This entry identifies L-galactono-gamma-lactone dehydrogenase . This enzyme performs the final step in ascorbic acid biosynthesis in higher plants. The protein is homologous to ascorbic acid biosynthesis enzymes of other species: L-gulono-gamma-lactone oxidase in rat and L-galactono-gamma-lactone oxidase in yeast. All ...

[ "GO:0016633" ]

[ "galactonolactone dehydrogenase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01676" ]

[ "GLDHase" ]

[ 742 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC" ]

[ "1.3.2.3", "GenProp1230", "GenProp1637", "PWY-8143", "PWY-882" ]

[ "EC:1.3.2.3", "GP:GenProp1230", "GP:GenProp1637", "METACYC:PWY-8143", "METACYC:PWY-882" ]

5

[ "7a24", "7sml", "8qmy", "8qnb", "8qnc", "8qnr" ]

6

[]

0

[ "IPR010031" ]

[]

1

0

1

[ "Eukaryota" ]

[ 742 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 4 ]

3

true

Family

Galactonolactone dehydrogenase

GL_DH

2

IPR010030

10,030

L-gulonolactone oxidase, plant

GULO_Plant

Family

2,016

false

This entry represents a family of L-gulonolactone oxidases. At least seven distinct members are found in Arabidopsis thaliana (Mouse-ear cress). This group of proteins may be involved in the biosynthesis of ascorbic acid [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01677" ]

[ "pln_FAD_oxido" ]

[ 2016 ]

1

[ "EC" ]

[ "1.1.3.8" ]

[ "EC:1.1.3.8" ]

1

[]

0

[ "PUB00074288" ]

[ "20622436" ]

[ "The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid." ]

[ 2010 ]

1

[]

0

null

[ "Embryophyta" ]

[ 2016 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 18, 16 ]

3

true

Family

L-gulonolactone oxidase, plant

GULO_Plant

6

IPR010031

10,031

L-gulonolactone/D-arabinono-1,4-lactone oxidase-like

FAD_lactone_oxidase-like

Family

19,920

false

This entry identifies a family of at least two different sugar 1,4 lactone oxidases, both involved in synthesising ascorbic acid or a derivative. These include L-gulono-1,4-lactone dehydrogenase from bacteria ([ec:1.1.2.-]), L-gulonolactone oxidase ( ) from mammals and D-arabinono-1,4-lactone oxidase Alo1 ( ) from yeas...

[ "GO:0016899" ]

[ "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF000136", "PTHR43762" ]

[ "LGO_GLO", "" ]

[ 10328, 19878 ]

2

[ "EC" ]

[ "1.1.3" ]

[ "EC:1.1.3" ]

1

[ "1i19", "2i0k", "2vfr", "2vfs", "2vft", "2vfu", "2vfv", "3js8", "4aut", "4f4q", "4fdn", "4fdo", "4fdp", "4feh", "4ff6", "4g3t", "4g3u", "4kw5", "4ncr", "4p8c", "4p8h", "4p8k", "4p8l", "4p8m", "4p8n", "4p8p", "4p8t", "4p8y", "4pfa", "4pfd", "5oel", "5oep"...

46

[ "PUB00062468", "PUB00101423" ]

[ "22956199", "19299584" ]

[ "Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis.", "Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis." ]

[ 2012, 2009 ]

2

[]

[ "IPR010029", "IPR030654" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 34, 13721, 5953, 24, 188 ]

5

[ "Arabidopsis thaliana", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea may...

[ 3, 3, 1, 2, 3, 1, 1, 7 ]

8

true

Family

L-gulonolactone/D-arabinono-1,4-lactone oxidase-like

FAD_lactone_oxidase-like

6

IPR010033

10,033

HAD-superfamily phosphatase, subfamily IIIC

HAD_SF_ppase_IIIC

Domain

6,796

false

This entry represents the IIIC subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate nucleophile hydrolases. Subfamily III, which includes subfamily IIIA ( ) and subfamily IIIB ( ) contains sequences which do not contain either of the insert domains between the 1st and 2nd conserved catalytic motifs, su...

[]

0

[ "NCBIFAM" ]

[ "TIGR01681" ]

[ "HAD-SF-IIIC" ]

[ 6796 ]

1

[]

0

[ "1u7o", "1u7p", "2wm8", "3slr", "8i8b", "8vwi", "8vwj", "9h2a", "9h2b" ]

9

[ "PUB00003337", "PUB00009589" ]

[ "7966317", "11601995" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases." ]

[ 1994, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 126, 3399, 3067, 159, 45 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 4, 1, 1, 1, 1, 7, 3, 1, 1, 3 ]

10

true

Domain

HAD-superfamily phosphatase, subfamily IIIC

HAD_SF_ppase_IIIC

9

IPR010035

10,035

ThiS, thiamine-biosynthesis

Thi_S

Family

17,054

false

This entry identifies the ThiS family, which are thiamine-biosynthesis proteins related to MoaD. MoaD is a molybdenum cofactor biosynthesis protein. Both ThiS and MoaD proteins are involved in sulphur transfer.

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR34472", "TIGR01683" ]

[ "", "thiS" ]

[ 15543, 17047 ]

2

[ "GP", "GP" ]

[ "GenProp0250", "GenProp1175" ]

[ "GP:GenProp0250", "GP:GenProp1175" ]

2

[ "1f0z", "1tyg", "1zud", "2cu3", "2htm", "2k5p", "2lek", "3cwi" ]

8

[]

0

[ "IPR003749" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 16466, 358, 220 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ThiS, thiamine-biosynthesis

Thi_S

5

IPR010036

10,036

Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type

MDP_1_eu_arc

Family

4,431

false

This entry represents two closely related clades of sequences from eukaryotes and archaea, however, some uncharacterised bacterial sequences are also included in this family. The mouse enzyme has been characterised as a phosphatase and has been positively identified as a member of the haloacid dehalogenase (HAD) superf...

[ "GO:0016791" ]

[ "phosphatase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF12689", "PTHR17901", "TIGR01685" ]

[ "Acid_PPase", "", "MDP-1" ]

[ 4322, 4228, 2657 ]

3

[ "EC" ]

[ "3.1.3.48" ]

[ "EC:3.1.3.48" ]

1

[ "1u7o", "1u7p", "2wm8" ]

3

[ "PUB00009589", "PUB00013839", "PUB00031695" ]

[ "11601995", "10889041", "15461449" ]

[ "MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases.", "MDP-1: A novel eukaryotic magnesium-dependent phosphatase.", "X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily." ]

[ 2001, 2000, 2004 ]

3

[]

[ "IPR035679" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Imitervirales", "metagenomes" ]

[ 113, 100, 4211, 2, 5 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 5, 1, 3, 1, 1, 9, 3, 1, 1, 5 ]

10

true

Family

Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type

MDP_1_eu_arc

3

IPR010037

10,037

FkbH domain

FkbH_domain

Domain

3,328

false

This entry describes a domain of unknown function. One of proteins with this domain is a modular polyketide synthase, which is 4800 amino acids in length from Streptomyces avermitilis, where the domain is the C-terminal segment. By contrast, the FkbH protein from Streptomyces hygroscopicus ( ) apparently contains only ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01686" ]

[ "FkbH" ]

[ 3328 ]

1

[]

0

[ "3slr" ]

1

[ "PUB00003337", "PUB00013763" ]

[ "7966317", "10863099" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual pol...

[ 1994, 2000 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13, 3193, 78, 44 ]

4

[]

0

true

Domain

FkbH domain

FkbH_domain

6

IPR010038

10,038

MoaD, archaeal-type

MoaD_arc-typ

Family

3,115

false

Members of this family appear to be mainly archaeal and bacterial versions of MoaD, subunit 1 of molybdopterin converting factor. Small archaeal modifier protein 1 (SAM1) is a member of this family and it is involved in protein tagging in an ubiquitin-like system from archaea known as SAMPylation [ ]. It is not known w...

[]

0

[ "NCBIFAM" ]

[ "TIGR01687" ]

[ "moaD_arch" ]

[ 3115 ]

1

[]

0

[ "1v8c", "1vjk", "2g1e", "2k22", "2l52", "2l83", "2m19", "3po0", "4hro" ]

9

[ "PUB00058154", "PUB00058155", "PUB00058156", "PUB00058157" ]

[ "20547064", "20054389", "21368171", "17064282" ]

[ "SAMPyling proteins in archaea.", "Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii.", "E1- and ubiquitin-like proteins provide a direct link between protein conjugation and sulfur transfer in archaea.", "Enzymatic activation of sulfur for incorporation into biomolecules in prokar...

[ 2010, 2010, 2011, 2006 ]

4

[ "IPR003749" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1120, 1840, 58, 97 ]

4

[]

0

true

Family

MoaD, archaeal-type

MoaD_arc-typ

5

IPR010039

10,039

Capsule biosynthesis phosphatase

EcbF_BcbF

Family

312

false

This entry describes a small family of highly conserved proteins (>60% identity). Two of these, BcbF and EcbF of Pasteurella multocida are believed to be part of the capsule polysaccharide biosynthesis machinery because they are co-transcribed from a locus devoted to that purpose [ ]. In P. multocida there are six diff...

[]

0

[ "NCBIFAM" ]

[ "TIGR01689" ]

[ "EcbF-BcbF" ]

[ 312 ]

1

[]

0

[ "1xpj" ]

1

[ "PUB00003337", "PUB00013832" ]

[ "7966317", "10699509" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "Genetic organisation of the capsule biosynthetic locus of Pasteurella multocida M1404 (B:2)." ]

[ 1994, 2000 ]

2

[]

0

null

[ "Bacteria", "Diploscapter pachys" ]

[ 311, 1 ]

2

[]

0

true

Family

Capsule biosynthesis phosphatase

EcbF_BcbF

9

IPR010043

10,043

Bifunctional uridylyltransferase/uridylyl-removing enzyme

GlnD

Family

15,429

false

GlnD is a uridylyltransferase/uridylyl-removing enzyme for signal-transduction protein PII which acts as the sensory component of the nitrogen regulation (ntr) system [ , ]. The ntr system modulates nitrogen metabolism in response to the prevailing nitrogen source and the requirements of the cell. During nitrogen fixat...

[ "GO:0008773" ]

[ "[protein-PII] uridylyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00277", "PIRSF006288", "PTHR47320", "TIGR01693" ]

[ "PII_uridylyl_transf", "PII_uridyltransf", "", "UTase_glnD" ]

[ 13516, 12567, 15428, 11785 ]

4

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.59", "3.1.4.-", "PWY-5978", "PWY-6129", "PWY-6689", "PWY-7119", "PWY-7366" ]

[ "EC:2.7.7.59", "EC:3.1.4.-", "METACYC:PWY-5978", "METACYC:PWY-6129", "METACYC:PWY-6689", "METACYC:PWY-7119", "METACYC:PWY-7366" ]

7

[]

0

[ "PUB00006542", "PUB00015136", "PUB00015137" ]

[ "6130097", "11065377", "11810255" ]

[ "Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme.", "The Rhizobium leguminosarum bv. viciae glnD gene, encoding a uridylyltransferase/uridylyl-removing enzyme, is expressed in the root nodule but is not essential for nit...

[ 1983, 2000, 2002 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14628, 381, 420 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 1, 4, 11 ]

4

true

Family

Bifunctional uridylyltransferase/uridylyl-removing enzyme

GlnD

8

IPR010044

10,044

Methylthioadenosine phosphorylase (MTAP)

MTAP

Family

13,361

false

This entry represents the methylthioadenosine phosphorylase (MTAP). MTAP catalyses the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. It is involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. It is responsible for the first step i...

[ "GO:0017061" ]

[ "S-methyl-5-thioadenosine phosphorylase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_01963", "PTHR42679", "TIGR01694", "cd09010" ]

[ "MTAP", "", "MTAP", "MTAP_SsMTAPII_like_MTIP" ]

[ 12031, 13269, 9842, 12895 ]

4

[ "EC", "EC", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.2", "2.4.2.28", "GenProp0729", "PWY-6756", "PWY-8130", "R-BTA-1237112", "R-CEL-1237112", "R-DME-1237112", "R-DRE-1237112", "R-HSA-1237112", "R-HSA-8950505", "R-MMU-1237112", "R-SCE-1237112", "R-SPO-1237112" ]

[ "EC:2.4.2", "EC:2.4.2.28", "GP:GenProp0729", "METACYC:PWY-6756", "METACYC:PWY-8130", "REACTOME:R-BTA-1237112", "REACTOME:R-CEL-1237112", "REACTOME:R-DME-1237112", "REACTOME:R-DRE-1237112", "REACTOME:R-HSA-1237112", "REACTOME:R-HSA-8950505", "REACTOME:R-MMU-1237112", "REACTOME:R-SCE-1237112",...

14

[ "1cb0", "1cg6", "1k27", "1sd1", "1sd2", "1v4n", "1wta", "2a8y", "3ozb", "3ozc", "3ozd", "3oze", "3t94", "4glf", "4glj", "4l5a", "4l5c", "4l5y", "4l6i", "5eub", "5f73", "5f76", "5f77", "5f78", "5f7j", "5f7o", "5f7x", "5f7z", "5fak", "5tc5", "5tc6", "5tc7"...

44

[ "PUB00060784", "PUB00060785" ]

[ "2108157", "3091600" ]

[ "Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase.", "Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta." ]

[ 1990, 1986 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 840, 8253, 3923, 345 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 3, 6, 15, 1, 1, 3, 1, 1 ]

9

true

Family

Methylthioadenosine phosphorylase (MTAP)

MTAP

5

IPR010045

10,045

Phosphopentomutase

DeoB

Family

11,157

false

This entry describes bacterial phosphopentomutase. This protein is involved in the purine and pyrimidine salvage pathway of nucleotide synthesis. It catalyses a phosphotransfer on ribose and deoxyribose, converting D-ribose 1-phosphate to D-ribose 5-phosphate, and 2-deoxy-D-ribose 1-phosphate to 2-deoxy-D-ribose 5-phos...

[ "GO:0000287", "GO:0008973", "GO:0009117", "GO:0043094", "GO:0005737" ]

[ "magnesium ion binding", "phosphopentomutase activity", "nucleotide metabolic process", "metabolic compound salvage", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00740", "PIRSF001491", "PTHR21110", "TIGR01696", "cd16009" ]

[ "Phosphopentomut", "Ppentomutase", "", "deoB", "PPM" ]

[ 9345, 10034, 11154, 9462, 10166 ]

5

[ "EC", "GP", "GP", "GP", "GP", "METACYC" ]

[ "5.4.2.7", "GenProp1278", "GenProp1559", "GenProp1631", "GenProp1752", "PWY-7180" ]

[ "EC:5.4.2.7", "GP:GenProp1278", "GP:GenProp1559", "GP:GenProp1631", "GP:GenProp1752", "METACYC:PWY-7180" ]

6

[ "3m7v", "3m8w", "3m8y", "3m8z", "3ot9", "3twz", "3tx0", "3un2", "3un3", "3un5", "3uny", "3uo0", "4lr7", "4lr8", "4lr9", "4lra", "4lrb", "4lrc", "4lrd", "4lre", "4lrf", "4n7t" ]

22

[ "PUB00014944" ]

[ "9692190" ]

[ "Phosphopentomutase of Bacillus stearothermophilus TH6-2: the enzyme and its gene ppm." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 11033, 16, 108 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 2 ]

2

true

Family

Phosphopentomutase

DeoB

1

IPR010046

10,046

Oxidoreductase alpha (molybdopterin) subunit

Mopterin_OxRdtse_a_bac

Family

11,592

false

This entry includes a well-defined clade of molybdopterin-dependent formate dehydrogenases, bacterial type [ , , , ]. It represents the alpha subunit, which contains a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulphur clusters and cytochromes. This entry also includes pro...

[ "GO:0008863", "GO:0030151", "GO:0051539" ]

[ "formate dehydrogenase (NAD+) activity", "molybdenum ion binding", "4 iron, 4 sulfur cluster binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "NCBIFAM" ]

[ "TIGR01701" ]

[ "Fdhalpha-like" ]

[ 11592 ]

1

[]

0

[]

0

[ "PUB00009739", "PUB00013252", "PUB00027834", "PUB00027901", "PUB00027976", "PUB00073482" ]

[ "9036855", "12694615", "12948771", "7747941", "8052647", "11731152" ]

[ "Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.", "Regulatory network of acid resistance genes in Escherichia coli.", "Formate dehydrogenase--a versatile enzyme in changing environments.", "The hydrogenases and formate dehydrogenases ...

[ 1997, 2003, 2003, 1994, 1994, 2001 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8, 11525, 7, 52 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Oxidoreductase alpha (molybdopterin) subunit

Mopterin_OxRdtse_a_bac

7

IPR010047

10,047

Ni-containing CO dehydrogenase

CODH

Family

1,827

false

This entry describes the Ni-containing carbon monoxide dehydrogenase (CODH) family ( ). These enzymes reversibly oxidise CO to CO(2), and play key roles in the energy-yielding pathways of various autotrophic anaerobes, allowing these organisms to grow with CO as the sole carbon source [ ]. The active sites of these enz...

[ "GO:0016151", "GO:0043885", "GO:0051539", "GO:0006091" ]

[ "nickel cation binding", "anaerobic carbon-monoxide dehydrogenase activity", "4 iron, 4 sulfur cluster binding", "generation of precursor metabolites and energy" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PIRSF", "NCBIFAM", "CDD" ]

[ "PIRSF005023", "TIGR01702", "cd01915" ]

[ "CODH", "CO_DH_cata", "CODH" ]

[ 1547, 1821, 605 ]

3

[ "EC", "METACYC", "METACYC" ]

[ "1.2.7.4", "PWY-5372", "PWY-6780" ]

[ "EC:1.2.7.4", "METACYC:PWY-5372", "METACYC:PWY-6780" ]

3

[ "1jqk", "1mjg", "1oao", "1su6", "1su7", "1su8", "1suf", "2yiv", "2z8y", "3b51", "3b52", "3b53", "3i01", "3i04", "3i39", "4udx", "4udy", "5fle", "6b6v", "6b6w", "6b6x", "6b6y", "6dc2", "6elq", "6onc", "6ond", "6ons", "6t7j", "6vwy", "6vwz", "6vx0", "6vx1"...

111

[ "PUB00015141", "PUB00015142", "PUB00015143", "PUB00015144" ]

[ "12627225", "15221479", "15248760", "14646063" ]

[ "Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase.", "Crystallographic evidence for a CO/CO(2) tunnel gating mechanism in the bifunctional carbon monoxide dehydrogenase/acetyl coenzyme A synthase from Moorella thermoacetica.", "CO-induce...

[ 2003, 2004, 2004, 2003 ]

4

[ "IPR004137" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Cyprideis torosa", "unclassified sequences" ]

[ 190, 1556, 1, 80 ]

4

[]

0

true

Family

Ni-containing CO dehydrogenase

CODH

9

IPR010048

10,048

Hydroxylamine reductase

Hydroxylam_reduct

Family

6,775

false

Hybrid cluster proteins (HCP, or Prismane) have been identified in bacteria, archaea and eukaryotic protozoa. No specific function has yet been assigned to these proteins, but it may involve oxidoreductase enzymatic activity. These proteins contain one 4Fe-4S cluster, and one hybrid 4Fe-2O-2S cluster, the latter being ...

[ "GO:0016661", "GO:0051536", "GO:0005737" ]

[ "oxidoreductase activity, acting on other nitrogenous compounds as donors", "iron-sulfur cluster binding", "cytoplasm" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "NCBIFAM", "CDD" ]

[ "MF_00069", "PIRSF000076", "TIGR01703", "cd01914" ]

[ "Hydroxylam_reduct", "HCP", "hybrid_clust", "HCP" ]

[ 6658, 5526, 6771, 5374 ]

4

[ "EC" ]

[ "1.7.99.1" ]

[ "EC:1.7.99.1" ]

1

[ "1e1d", "1e2u", "1e9v", "1gn9", "1gnl", "1gnt", "1oa0", "1oa1", "1upx", "1w9m", "7de4", "7e0l", "7wsx", "8cnr", "8cns" ]

15

[ "PUB00015144", "PUB00015150" ]

[ "14646063", "12764602" ]

[ "Structure of the hybrid cluster protein (HCP) from Desulfovibrio desulfuricans ATCC 27774 containing molecules in the oxidized and reduced states.", "Reduced hybrid cluster proteins (HCP) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at high resolution u...

[ 2003, 2003 ]

2

[ "IPR004137" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 277, 6228, 212, 58 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Hydroxylamine reductase

Hydroxylam_reduct

9

IPR010049

10,049

MTA/SAH nucleosidase

MTA_SAH_Nsdase

Family

11,492

false

This entry represents the enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) ( ) which acts on its two substrates at the same active site. This enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulphur ligan...

[ "GO:0008782", "GO:0008930", "GO:0009164", "GO:0019509" ]

[ "adenosylhomocysteine nucleosidase activity", "methylthioadenosine nucleosidase activity", "nucleoside catabolic process", "L-methionine salvage from methylthioadenosine" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_01684", "TIGR01704" ]

[ "Salvage_MtnN", "MTA_SAH-Nsdase" ]

[ 4216, 11491 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.2.9", "GenProp0730", "GenProp0757", "GenProp1482", "PWY-6151", "PWY-6153", "PWY-6154", "PWY-8131" ]

[ "EC:3.2.2.9", "GP:GenProp0730", "GP:GenProp0757", "GP:GenProp1482", "METACYC:PWY-6151", "METACYC:PWY-6153", "METACYC:PWY-6154", "METACYC:PWY-8131" ]

8

[ "1jys", "1nc1", "1nc3", "1y6q", "1y6r", "1z5n", "1z5o", "1z5p", "1zos", "3bl6", "3df9", "3dp9", "3eei", "3mms", "3nm4", "3nm5", "3nm6", "3o4v", "4bmx", "4bmy", "4bmz", "4bn0", "4f1w", "4f2p", "4f2w", "4f3c", "4f3k", "4ffs", "4g41", "4g89", "4gmh", "4jos"...

68

[ "PUB00013756", "PUB00013829", "PUB00050679", "PUB00099944" ]

[ "10574451", "11591349", "18453700", "21166890" ]

[ "Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis.", "Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.", "Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocys...

[ 1999, 2001, 2008, 2011 ]

4

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "Siphoviridae sp. ctaLC6", "unclassified sequences" ]

[ 11339, 1, 74, 1, 77 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MTA/SAH nucleosidase

MTA_SAH_Nsdase

8

IPR010050

10,050

5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative

MTA_SAH_nuc_hyp

Family

930

false

This entry represents the enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, which acts on its two substrates at the same active site , and similar sequences mainly found in alphaproteobacteria. This group of sequences is related but distinct to . This enzyme is involved in the recycling of the componen...

[]

0

[ "NCBIFAM" ]

[ "TIGR01705" ]

[ "MTA_SAH-nuc-hyp" ]

[ 930 ]

1

[]

0

[ "4pr3" ]

1

[ "PUB00013756", "PUB00013829", "PUB00106629" ]

[ "10574451", "11591349", "24657441" ]

[ "Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis.", "Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.", "Crystal structure and biochemical studies of Brucella melitensis 5'-methylt...

[ 1999, 2001, 2014 ]

3

[]

0

null

[ "Pseudomonadota", "ecological metagenomes" ]

[ 926, 4 ]

2

[]

0

true

Family

5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative

MTA_SAH_nuc_hyp

8

IPR010051

10,051

Periplasmic nitrate reductase, large subunit

Periplasm_NO3_reductase_lsu

Family

3,755

false

This entry represents the large subunit of a family of nitrate reductases found in proteobacteria which are localised to the periplasm. This subunit binds molybdopterin and contains a twin-arginine motif at the N terminus. The protein associates with NapB, a soluble haem-containing protein and NapC, a membrane-bound cy...

[ "GO:0008940", "GO:0030151" ]

[ "nitrate reductase activity", "molybdenum ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01630", "TIGR01706" ]

[ "Nitrate_reduct_NapA", "NAPA" ]

[ 3650, 3444 ]

2

[ "EC", "GP", "METACYC" ]

[ "1.9.6.1", "GenProp1504", "PWY-5674" ]

[ "EC:1.9.6.1", "GP:GenProp1504", "METACYC:PWY-5674" ]

3

[ "1ogy", "2jim", "2jio", "2jip", "2jiq", "2jir", "2nap", "2nya", "2v3v", "2v45", "3ml1", "3o5a" ]

12

[ "PUB00013806", "PUB00013835", "PUB00013852" ]

[ "7639719", "11844760", "8376334" ]

[ "The napEDABC gene cluster encoding the periplasmic nitrate reductase system of Thiosphaera pantotropha.", "Periplasmic nitrate reductase (NapABC enzyme) supports anaerobic respiration by Escherichia coli K-12.", "Structure and function of a periplasmic nitrate reductase in Alcaligenes eutrophus H16." ]

[ 1995, 2002, 1993 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3724, 3, 28 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Periplasmic nitrate reductase, large subunit

Periplasm_NO3_reductase_lsu

5

IPR010052

10,052

Type II secretion system protein GspI

T2SS_protein-GspI

Family

5,728

false

GspI is a pseudopilin component of the type II secretion system (T2SS). It contains the prepilin signal sequences [ ]. In Pseudomonas aeruginosa GspI homologue, known as XcpV, has been suggested to be the central component and initiator of pseudopilus formation [ ]. The type II secretion system (T2SS) is one of several...

[ "GO:0015628", "GO:0015627" ]

[ "protein secretion by the type II secretion system", "type II protein secretion system complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR38779", "TIGR01707" ]

[ "", "gspI" ]

[ 5659, 4607 ]

2

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "2ret", "3cfi", "3ci0", "5bw0", "5vtm", "6utu" ]

6

[ "PUB00002231", "PUB00051842", "PUB00093998", "PUB00094002", "PUB00094004", "PUB00094020" ]

[ "8407845", "19217396", "30767847", "28258547", "22523076", "19828448" ]

[ "Isolation and analysis of eight exe genes and their involvement in extracellular protein secretion and outer membrane assembly in Aeromonas hydrophila.", "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Architecture, Function, and Subst...

[ 1993, 2009, 2019, 2017, 2012, 2009 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5617, 13, 98 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type II secretion system protein GspI

T2SS_protein-GspI

4

IPR010054

10,054

Type II secretion system protein GspG

Type2_sec_GspG

Family

8,139

false

GspG is the major pseudopilin of the type 2 secretion systems (T2SSs). The N-terminal hydrophobic helices of the GspG subunits arrange within the core of the pseudopilus, with the C-terminal domains and the Ca2+-binding sites located at the surface. The structure of GspG (also known as PulG) has been revealed [ ]. The ...

[ "GO:0015628", "GO:0015627" ]

[ "protein secretion by the type II secretion system", "type II protein secretion system complex" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01710" ]

[ "typeII_sec_gspG" ]

[ 8139 ]

1

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "1t92", "2kep", "3fu1", "3g20", "3gn9", "4lw9", "5o2y", "5wda" ]

8

[ "PUB00051842", "PUB00093998", "PUB00093999", "PUB00094002", "PUB00094004" ]

[ "19217396", "30767847", "28993624", "28258547", "22523076" ]

[ "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Architecture, Function, and Substrates of the Type II Secretion System.", "Structure of the calcium-dependent type 2 secretion pseudopilus.", "1H, 15N and 13C resonance assignments and s...

[ 2009, 2019, 2017, 2017, 2012 ]

5

[ "IPR000983" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7966, 16, 157 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type II secretion system protein GspG

Type2_sec_GspG

4

IPR010055

10,055

Type II secretion system protein GspJ

T2SS_protein-GspJ

Family

5,209

false

This family of proteins represents GspJ which is targeted to the membrane of Escherichia coli. GspJ forms a complex with GspI and GspK, which is part of the type 2 secretion system, involved in the translocation of proteins across the outer membrane of E.coli. The GSPK-I-J complex has quasi-helical characteristics [ ]....

[ "GO:0015628", "GO:0015627" ]

[ "protein secretion by the type II secretion system", "type II protein secretion system complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF11612", "TIGR01711" ]

[ "T2SSJ", "gspJ" ]

[ 5209, 3008 ]

2

[ "GP" ]

[ "GenProp0053" ]

[ "GP:GenProp0053" ]

1

[ "2ret", "3cfi", "3ci0", "3nje", "5bw0", "5vtm", "6utu" ]

7

[ "PUB00051007", "PUB00051842", "PUB00093998", "PUB00094002", "PUB00094004" ]

[ "18438417", "19217396", "30767847", "28258547", "22523076" ]

[ "Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system.", "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Architecture, Function, and Substrates of the Type II Secretion System.", "1...

[ 2008, 2009, 2019, 2017, 2012 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Halorubrum tibetense", "unclassified sequences" ]

[ 5106, 12, 1, 90 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type II secretion system protein GspJ

T2SS_protein-GspJ

2

IPR010056

10,056

Phage replisome organiser, N-terminal domain

Phage_rep_org__N

Domain

2,130

false

This entry represents the N-terminal domain of a small family of phage proteins. The proteins in this group contain a region of low-complexity sequence that reflects DNA direct repeats able to function as an origin of phage replication. The low-complexity region is adjacent to this N-terminal domain.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09681", "TIGR01714" ]

[ "Phage_rep_org_N", "phage_rep_org_N" ]

[ 2130, 2020 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Polyphaga", "Viruses", "unclassified sequences" ]

[ 1926, 2, 155, 47 ]

4

[]

0

true

Domain

Phage replisome organiser, N-terminal domain

Phage_rep_org__N

5

IPR010057

10,057

HTH-type transcriptional regulator Rgg, C-terminal domain

Transcription_activator_Rgg_C

Domain

4,684

false

This domain is found at the C-terminal of HTH-type transcriptional regulator Rgg (also called RopB) from Streptococcus gordonii, and similar proteins predominantly found in Firmicutes. Rgg is a peptide pheromone receptor that directly binds pheromones transported to the cytosol. The large C-terminal repeat domain conta...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF21259", "TIGR01716" ]

[ "Rgg_C", "RGG_Cterm" ]

[ 4629, 4041 ]

2

[]

0

[ "4ryk", "4yv6", "4yv9", "5dl2", "5w4m", "5w4n", "6dql", "6w1a", "6w1e", "6w1f", "7ji0", "7zcv", "9lth" ]

13

[ "PUB00039428", "PUB00099792", "PUB00152672", "PUB00152673", "PUB00152674" ]

[ "16339309", "17038121", "26714274", "25847993", "29030429" ]

[ "Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.", "Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides.", "Structural and functional analysis of RopB: a major virulence regulator in Strept...

[ 2005, 2006, 2016, 2015, 2017 ]

5

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 4678, 6 ]

2

[]

0

true

Domain

HTH-type transcriptional regulator Rgg, C-terminal domain

Transcription_activator_Rgg_C

8

IPR010058

10,058

Uridine phosphorylase

Uridine_phosphorylase

Family

2,637

false

This entry represents a family of bacterial and archaeal uridine phosphorylases unrelated to the mammalian enzymes of the same name. The Escherichia coli [ ], Salmonella [ ] and Klebsiella [ ] genes have been characterised. Sequences from Clostridium, Streptomyces, Treponema, Aeropyrum and Pyrobaculum are also included...

[ "GO:0004850", "GO:0009166", "GO:0005737" ]

[ "uridine phosphorylase activity", "nucleotide catabolic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01718" ]

[ "Uridine-psphlse" ]

[ 2637 ]

1

[ "EC", "GP", "METACYC" ]

[ "2.4.2.3", "GenProp1576", "PWY-5532" ]

[ "EC:2.4.2.3", "GP:GenProp1576", "METACYC:PWY-5532" ]

3

[ "1k3f", "1lx7", "1rxc", "1rxs", "1rxu", "1rxy", "1ryz", "1sj9", "1t0u", "1tgv", "1tgy", "1u1c", "1u1d", "1u1e", "1u1f", "1u1g", "1y1q", "1y1r", "1y1s", "1y1t", "1zl2", "2hn9", "2hrd", "2hsw", "2hwu", "2i8a", "2iq5", "2oec", "2oxf", "2pga", "2qdk", "2rj3"...

74

[ "PUB00000763", "PUB00002872", "PUB00013784", "PUB00013819" ]

[ "8534998", "7929153", "9526114", "16751" ]

[ "Molecular cloning and nucleotide sequence of purine nucleoside phosphorylase and uridine phosphorylase genes from Klebsiella sp.", "Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosph...

[ 1995, 1994, 1998, 1977 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Ecdysozoa", "Siphoviridae sp. ctjdk2", "metagenomes" ]

[ 105, 2518, 2, 1, 11 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uridine phosphorylase

Uridine_phosphorylase

9

IPR010059

10,059

Uridine phosphorylase, eukaryotic

Uridine_phosphorylase_euk

Family

2,965

false

This entry represents a clade of mainly eukaryotic uridine phosphorylases. Uridine phosphorylase (UP) catalyzes the reversible phosphorolysis of uracil ribosides and analogous compounds to their respective nucleobases and ribose 1-phosphate. Human UPP1 has a role in the activation of pyrimidine nucleoside analogues use...

[ "GO:0004850", "GO:0009166", "GO:0005737" ]

[ "uridine phosphorylase activity", "nucleotide catabolic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR01719", "cd17763" ]

[ "euk_UDPppase", "UP_hUPP-like" ]

[ 2935, 2840 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.2.3", "GenProp1380", "GenProp1410", "GenProp1576", "PWY-5532", "R-CEL-73614", "R-CEL-73621", "R-HSA-73614", "R-HSA-73621", "R-MMU-73614", "R-MMU-73621" ]

[ "EC:2.4.2.3", "GP:GenProp1380", "GP:GenProp1410", "GP:GenProp1576", "METACYC:PWY-5532", "REACTOME:R-CEL-73614", "REACTOME:R-CEL-73621", "REACTOME:R-HSA-73614", "REACTOME:R-HSA-73621", "REACTOME:R-MMU-73614", "REACTOME:R-MMU-73621" ]

11

[ "2xrf", "3eue", "3euf", "3ku4", "3kuk", "3kvr", "3kvy", "3nbq", "3p0e", "3p0f", "4txh", "4txj", "4txl", "4txm", "4txn", "5cyf", "5cyg", "6kd3" ]

18

[ "PUB00051804", "PUB00071562" ]

[ "19291308", "19645718" ]

[ "Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.", "Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans." ]

[ 2009, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 8, 2956, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 5, 6, 10, 4 ]

6

true

Family

Uridine phosphorylase, eukaryotic

Uridine_phosphorylase_euk

6

IPR010060

10,060

Non-ribosomal peptide synthase

NRPS_synth

Domain

13,485

false

This entry represents a region of 171 amino acids long and contains three very highly conserved regions. At the N terminus is a nearly invariant lysine (position 11) followed by xxxRxxPxxGxGYG in which the proline and the first glycine are invariant. This is followed approximately 22 residues later by the motif FNYLG. ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01720" ]

[ "NRPS-para261" ]

[ 13485 ]

1

[]

0

[ "2xhg", "5isw", "5isx", "6ta8", "9bfd", "9bfe", "9bff", "9bfg", "9rde" ]

9

[ "PUB00033383", "PUB00033384", "PUB00033385", "PUB00033386", "PUB00033387", "PUB00155465" ]

[ "9427658", "7718566", "14670971", "1847909", "2768192", "17159203" ]

[ "The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.", "Gramicidin S synthetase 1 (phenylalanine racemase), a prototype of amino acid racemases containing the cofactor 4'-phosphopantetheine.", "The linear pentadecapeptid...

[ 1997, 1995, 2004, 1991, 1989, 2006 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13374, 99, 12 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Non-ribosomal peptide synthase

NRPS_synth

7

IPR010062

10,062

5,10-methenyltetrahydromethanopterin hydrogenase

HMD_

Family

79

false

The N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase system of methanogenic archaea is composed of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd, ) and F420-dependent methylenetetrahydromethanopterin dehydrogenase ( ) [ , ]. Hmd is an iron-sulphur-cluster-free enzyme that contains an intrinsic...

[ "GO:0047068", "GO:0019386" ]

[ "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "methanogenesis, from carbon dioxide" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01090", "PIRSF500165", "TIGR01723" ]

[ "HMD", "HMDI", "hmd_TIGR" ]

[ 70, 44, 79 ]

3

[ "EC", "GP", "METACYC" ]

[ "1.12.98.2", "GenProp0915", "PWY-7784" ]

[ "EC:1.12.98.2", "GP:GenProp0915", "METACYC:PWY-7784" ]

3

[ "2b0j", "3daf", "3dag", "3f46", "3f47", "3h65", "4jjf", "4jjg", "5ok4", "6ggu", "6hac", "6hae", "6hav", "6yk9", "6yka", "6ykb" ]

16

[ "PUB00013473", "PUB00014604", "PUB00014605", "PUB00016833" ]

[ "11081790", "8215796", "9151968", "15506791" ]

[ "Regulation of the synthesis of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) and of HmdII and HmdIII in Methanothermobacter marburgensis.", "Two N5,N10-methylenetetrahydromethanopterin dehydrogenases in the extreme thermophile Methanopyrus kandleri: characterization of the coenzyme F420-depende...

[ 2000, 1993, 1997, 2004 ]

4

[ "IPR024190" ]

[]

1

0

1

[ "Methanobacteriota", "bioreactor metagenome" ]

[ 78, 1 ]

2

[]

0

true

Family

5,10-methenyltetrahydromethanopterin hydrogenase

HMD_

2

IPR010064

10,064

Bacteriophage HK97-gp10, putative tail-component

HK97-gp10_tail

Family

8,361

false

This family is found in HK97-gp10-like phage proteins. These may be tail component proteins.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04883", "TIGR01725" ]

[ "HK97-gp10_like", "phge_HK97_gp10" ]

[ 7330, 5120 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "9mu2" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 55, 6977, 7, 1151, 171 ]

5

[]

0

true

Family

Bacteriophage HK97-gp10, putative tail-component

HK97-gp10_tail

3

IPR010065

10,065

Amino acid ABC transporter, permease protein, 3-TM domain

AA_ABC_transptr_permease_3TM

Domain

138,970

false

ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) [ ]. Thi...

[ "GO:0022857", "GO:0071705", "GO:0016020", "GO:0043190" ]

[ "transmembrane transporter activity", "nitrogen compound transport", "membrane", "ATP-binding cassette (ABC) transporter complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR01726" ]

[ "HEQRo_perm_3TM" ]

[ 138970 ]

1

[]

0

[ "4yms", "4ymt", "4ymu", "4ymv", "4ymw" ]

5

[ "PUB00014769", "PUB00072608", "PUB00072609", "PUB00087457" ]

[ "9873074", "24021237", "9520394", "1987170" ]

[ "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "Conformational changes of the bacterial type I ATP-binding cassette importer HisQMP2 at distinct steps of the catalytic cycle.", "In vitro disassembly and reassembly of an ABC tr...

[ 1999, 2014, 1998, 1991 ]

4

[ "IPR000515" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 646, 137370, 78, 876 ]

4

[ "Escherichia coli (strain K12)" ]

[ 10 ]

1

true

Domain

Amino acid ABC transporter, permease protein, 3-TM domain

AA_ABC_transptr_permease_3TM

1

IPR010067

10,067

Aliphatic sulfonates-binding protein

ABC_SsuA_sub-bd

Family

17,269

false

Members of this family are substrate-binding periplasmic proteins of ABC transporters. This subfamily includes SsuA, a member of a transporter operon needed to obtain sulphur from aliphatic sulphonates. Related proteins include taurine (NH2-CH2-CH2-S03H) binding proteins, the probable sulphate ester binding protein Ats...

[ "GO:0042626", "GO:0016020" ]

[ "ATPase-coupled transmembrane transporter activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01728" ]

[ "SsuA_fam" ]

[ 17269 ]

1

[]

0

[ "2x26", "3e4r", "3ksj", "3ksx" ]

4

[ "PUB00013474" ]

[ "10506196" ]

[ "The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 242, 16946, 10, 71 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

Aliphatic sulfonates-binding protein

ABC_SsuA_sub-bd

4

IPR010068

10,068

Taurine ABC transporter, substrate-binding protein TauA

Peri-bd_TauA

Family

3,202

false

This entry represents taurine-binding periplasmic protein TauA. TauA is part of tauABCD gene cluster involved in sulfonate transport in sulphate starvation condition. TauA plays a major role in ABC transport system and could be ideal candidate to serve as taurine catcher in biological fluids [ ]. The most closely relat...

[ "GO:0042597" ]

[ "periplasmic space" ]

[ "cellular_component" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR01729", "cd13560" ]

[ "taurine_ABC_bnd", "PBP2_taurine" ]

[ 2868, 2311 ]

2

[]

0

[ "6ssy", "6st0", "6st1", "6stl", "8pxh" ]

5

[ "PUB00062320" ]

[ "17203388" ]

[ "Functional characteristics of TauA binding protein from TauABC Escherichia coli system." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 3181, 5, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Taurine ABC transporter, substrate-binding protein TauA

Peri-bd_TauA

9

IPR010069

10,069

Toxin CdiA-like, Filamentous hemagglutinin motif repeats

CdiA_FHA1_rpt

Repeat

4,866

false

This entry represents several repeats of the filamentous hemagglutinin (FHA-1) motif, which have approximately 20 amino acids. The repeats are found at the N-terminal domain of Toxin CdiA from Escherichia coli and similar proteins mostly from bacterial species, including several plant and animal pathogens. The FHA-1 re...

[]

0

[ "NCBIFAM" ]

[ "TIGR01731" ]

[ "fil_hemag_20aa" ]

[ 4866 ]

1

[]

0

[]

0

[ "PUB00057480", "PUB00088209", "PUB00100043", "PUB00100044", "PUB00100045", "PUB00100046" ]

[ "21085179", "24657090", "33121148", "25174572", "28223500", "30388452" ]

[ "A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria.", "CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria.", "Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!", "The proton-motive force is required for translocation ...

[ 2010, 2014, 2020, 2014, 2017, 2018 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Halogeometricum salsisoli", "metagenomes" ]

[ 4803, 49, 1, 13 ]

4

[]

0

true

Repeat

Toxin CdiA-like, Filamentous hemagglutinin motif repeats

CdiA_FHA1_rpt

6

IPR010070

10,070

Sporulation protein YjcZ-like

YjcZ-like

Family

6,825

false

Endospores of B. subtilis are encased in a thick protein shell known as the spore coat. The coat's complex structure comprises an inner coat (IC) and an outer coat (OC), and includes more than 70 spore-specific proteins. This entry includes several sporulation-specific proteins including YjcZ [ ] and SscA, which is inv...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09680", "TIGR01732" ]

[ "YjcZ_2", "tiny_TM_bacill" ]

[ 6690, 6641 ]

2

[]

0

[]

0

[ "PUB00058247", "PUB00089623" ]

[ "14523132", "21670523" ]

[ "Bacillus subtilis spoVIF (yjcC) gene, involved in coat assembly and spore resistance.", "A novel small protein of Bacillus subtilis involved in spore germination and spore coat assembly." ]

[ 2003, 2011 ]

2

[]

0

null

[ "Bacillus phage SPbeta", "Bacteria", "Fungi incertae sedis", "marine sediment metagenome" ]

[ 1, 6821, 2, 1 ]

4

[]

0

true

Family

Sporulation protein YjcZ-like

YjcZ-like

3

IPR010071

10,071

Amino acid adenylation domain

AA_adenyl_dom

Domain

86,393

false

This entry represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalysed is aa + ATP to aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called 'A-domains' in that co...

[]

0

[ "NCBIFAM" ]

[ "TIGR01733" ]

[ "AA-adenyl-dom" ]

[ 86393 ]

1

[]

0

[ "1amu", "2vsq", "3dhv", "3e7w", "3e7x", "3fcc", "3fce", "3l8c", "3lgx", "3vnq", "3vnr", "3vns", "4d4g", "4d4h", "4d4i", "4d56", "4d57", "4gr4", "4gr5", "4pzp", "4zxh", "4zxi", "5es5", "5es6", "5es7", "5es8", "5es9", "5ja1", "5ja2", "5jnf", "5n81", "5n82"...

92

[ "PUB00013827" ]

[ "10021423" ]

[ "How do peptide synthetases generate structural diversity?" ]

[ 1999 ]

1

[ "IPR000873" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Mimiviridae", "unclassified sequences" ]

[ 73198, 13042, 31, 5, 117 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 1, 2 ]

5

true

Domain

Amino acid adenylation domain

AA_adenyl_dom

1

IPR010072

10,072

D-alanine--D-alanyl carrier protein ligase

DltA

Family

2,028

false

DltA is part of the operon for incorporation of D-Ala residues into lipoteichoic acids (LTAs), which requires the activity of four gene products (DltA to DltD). DltA is a cytoplasmic D-alanine-D-alanyl carrier protein ligase that catalyses the D-alanylation of the D-alanyl carrier protein DltC (or Dcp); DltB is a trans...

[ "GO:0005524", "GO:0047473", "GO:0070395" ]

[ "ATP binding", "D-alanine [D-alanyl carrier protein] ligase activity", "lipoteichoic acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00593", "TIGR01734" ]

[ "DltA", "D-ala-DACP-lig" ]

[ 1994, 1954 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "6.2.1.54", "GenProp0958", "GenProp1398", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-8040", "PWY-8343", "PWY-8443" ]

[ "EC:6.2.1.54", "GP:GenProp0958", "GP:GenProp1398", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-8040", "METACYC:PWY-8343", "METACYC:PWY-8443" ]

10

[ "3dhv", "3e7w", "3e7x", "3fcc", "3fce", "3l8c", "3lgx", "4pzp", "7r27", "7vhv" ]

10

[ "PUB00086696", "PUB00086797" ]

[ "11849532", "8682792" ]

[ "Formation of D-alanyl-lipoteichoic acid is required for adhesion and virulence of Listeria monocytogenes.", "The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC." ]

[ 2002, 1996 ]

2

[ "IPR044507" ]

[]

1

0

1

[ "Bacteria", "bioreactor metagenome" ]

[ 2026, 2 ]

2

[]

0

true

Family

D-alanine--D-alanyl carrier protein ligase

DltA

5

IPR010074

10,074

Phosphoribosylformylglycinamidine subunit PurL

PRibForGlyAmidine_synth_PurL

Family

14,669

false

This entry represents the small PurL, also known as phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as phosphoribosylformylglycinamidine synthase, PurL and formylglycinamidine ribonucleotide (FGAM) synthase, catalyzes the ATP-de...

[ "GO:0004642", "GO:0006189" ]

[ "phosphoribosylformylglycinamidine synthase activity", "'de novo' IMP biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00420", "NF002290", "PIRSF001587", "PTHR43555", "TIGR01736" ]

[ "PurL_2", "PRK01213.1", "FGAM_synthase_II", "", "FGAM_synth_II" ]

[ 14012, 12614, 12239, 14668, 13126 ]

5

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.5.3", "GenProp0110", "PWY-6121", "PWY-6122", "PWY-6277" ]

[ "EC:6.3.5.3", "GP:GenProp0110", "METACYC:PWY-6121", "METACYC:PWY-6122", "METACYC:PWY-6277" ]

5

[ "1vk3", "2hru", "2hry", "2hs0", "2hs3", "2hs4", "3d54", "3viu" ]

8

[ "PUB00016818", "PUB00016819" ]

[ "15301531", "15301530" ]

[ "Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography.", "The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Microbacterium phage Min1", "unclassified sequences" ]

[ 887, 13130, 54, 1, 597 ]

5

[]

0

true

Family

Phosphoribosylformylglycinamidine subunit PurL

PRibForGlyAmidine_synth_PurL

8

IPR010075

10,075

Phosphoribosylformylglycinamidine synthase subunit PurQ

PRibForGlyAmidine_synth_PurQ

Family

13,479

false

In Gram-negative bacteria and eukaryotes, formylglycinamideribonucleotide amidotransferase is a single protein. In archaea and Gram-positive bacteria it is formed from three proteins. This entry describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidin...

[ "GO:0004642", "GO:0006189" ]

[ "phosphoribosylformylglycinamidine synthase activity", "'de novo' IMP biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00421", "PIRSF001586", "PTHR47552", "TIGR01737" ]

[ "PurQ", "FGAM_synth_I", "", "FGAM_synth_I" ]

[ 12313, 13097, 12558, 12760 ]

4

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.5.1.2", "6.3.5.3", "GenProp0110", "PWY-5921", "PWY-6121", "PWY-6122", "PWY-6277" ]

[ "EC:3.5.1.2", "EC:6.3.5.3", "GP:GenProp0110", "METACYC:PWY-5921", "METACYC:PWY-6121", "METACYC:PWY-6122", "METACYC:PWY-6277" ]

7

[ "3d54" ]

1

[ "PUB00016819" ]

[ "15301530" ]

[ "The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 827, 12228, 30, 394 ]

4

[]

0

true

Family

Phosphoribosylformylglycinamidine synthase subunit PurQ

PRibForGlyAmidine_synth_PurQ

9

IPR010076

10,076

Pimeloyl-[acyl-carrier protein] methyl ester esterase

BioH

Family

3,428

false

This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin [ ]. Its exact function is unknown, but it has been shown to possess carboxylesterase activity with a preference for short acyl chain substrates [ ]. This enzyme belongs t...

[ "GO:0052689", "GO:0009102" ]

[ "carboxylic ester hydrolase activity", "biotin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01260", "TIGR01738" ]

[ "Carboxylester", "bioH" ]

[ 3183, 3333 ]

2

[ "EC", "GP", "METACYC" ]

[ "3.1.1.85", "GenProp0036", "PWY-6519" ]

[ "EC:3.1.1.85", "GP:GenProp0036", "METACYC:PWY-6519" ]

3

[ "1m33", "4etw", "4nmw", "6k5e" ]

4

[ "PUB00013477", "PUB00020998" ]

[ "11904168", "12732651" ]

[ "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway.", "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 3396, 3, 29 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pimeloyl-[acyl-carrier protein] methyl ester esterase

BioH

6

IPR010077

10,077

Herpes virus tegument protein

Herpes_virus_tegument

Family

247

false

This is a family of major tegument proteins from Herpesviruses. Herpesvirus tegument proteins counteract the intrinsic anti-viral defenses and support the early steps of infection. BNRF1 is the Epstein-Barr virus (EBV) major tegument protein and plays an important role in viral transport from the endosomes to the nucle...

[ "GO:0075733", "GO:0019033" ]

[ "intracellular transport of virus", "viral tegument" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01739" ]

[ "tegu_FGAM_synt" ]

[ 247 ]

1

[]

0

[]

0

[ "PUB00074597", "PUB00074599" ]

[ "16973549", "22102817" ]

[ "Epstein-Barr virus BNRF1 protein allows efficient transfer from the endosomal compartment to the nucleus of primary B lymphocytes.", "EBV tegument protein BNRF1 disrupts DAXX-ATRX to activate viral early gene transcription." ]

[ 2006, 2011 ]

2

[]

0

null

[ "Orthoherpesviridae" ]

[ 247 ]

1

[]

0

true

Family

Herpes virus tegument protein

Herpes_virus_tegument

6

IPR010078

10,078

Pur operon repressor

PurR_Bsub

Family

3,545

false

This entry represents the pur operon repressor PurR of low-GC Gram-positive bacteria. This homodimeric repressor contains a large region homologous to phosphoribosyltransferases and is inhibited by 5-phosphoribosyl 1-pyrophosphate [ ]. PurR is a DNA-binding transcriptional repressor that controls the expression of a nu...

[ "GO:0003677", "GO:0045892", "GO:0045982" ]

[ "DNA binding", "negative regulation of DNA-templated transcription", "negative regulation of purine nucleobase metabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01743" ]

[ "purR_Bsub" ]

[ 3545 ]

1

[]

0

[ "1o57", "1p4a", "7rmw" ]

3

[ "PUB00013478", "PUB00015789", "PUB00155436", "PUB00155437" ]

[ "7638212", "11591660", "10919400", "34967415" ]

[ "Identification of the Bacillus subtilis pur operon repressor.", "Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO.", "Mutations in the Bacillus subtilis purine repressor that perturb PR...

[ 1995, 2001, 2000, 2022 ]

4

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3535, 10 ]

2

[]

0

true

Family

Pur operon repressor

PurR_Bsub

9

IPR010079

10,079

Xanthine phosphoribosyltransferase

Xanthine_PRibTrfase

Family

6,496

false

This entry represent a xanthine-specific phosphoribosyltransferase of Bacillus subtilis and closely related proteins from other species, mostly from other Gram-positive bacteria. The adjacent gene is a xanthine transporter; B. subtilis can import xanthine for the purine salvage pathway or for catabolism to obtain nitro...

[ "GO:0016763", "GO:0043101", "GO:0046110" ]

[ "pentosyltransferase activity", "purine-containing compound salvage", "xanthine metabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01184", "TIGR01744" ]

[ "XPRTase", "XPRTase" ]

[ 6131, 6496 ]

2

[ "EC", "GP" ]

[ "2.4.2.22", "GenProp0696" ]

[ "EC:2.4.2.22", "GP:GenProp0696" ]

2

[ "1y0b", "2fxv", "6w1i" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 6434, 35, 5, 22 ]

4

[]

0

true

Family

Xanthine phosphoribosyltransferase

Xanthine_PRibTrfase

2

IPR010080

10,080

Thioester reductase-like domain

Thioester_reductase-like_dom

Domain

10,472

false

This domain includes the C-terminal domain from the fungal alpha aminoadipate reductase enzyme (also known as aminoadipate semialdehyde dehydrogenase) which is involved in the biosynthesis of lysine [ ], as well as the reductase-containing component of the myxochelin biosynthetic gene cluster, MxcG [ ]. The mechanism o...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR01746", "cd05235" ]

[ "Thioester-redct", "SDR_e1" ]

[ 10184, 8800 ]

2

[]

0

[ "4dqv", "4f6c", "4f6l", "4u5q", "4u7w", "4w4t", "5msc", "5msd", "5mso", "5msp", "5msq", "5msr", "5mss", "5mst", "5msu", "5msv", "5msw", "6vtj", "6vtz", "8v1x" ]

20

[ "PUB00000419", "PUB00013797", "PUB00013811", "PUB00013838", "PUB00027779", "PUB00027780", "PUB00081093", "PUB00081094", "PUB00081095", "PUB00081096", "PUB00081097" ]

[ "7742302", "11254122", "11029592", "10320345", "12604213", "12604210", "19011750", "19011748", "20423462", "19027726", "19061874" ]

[ "Short-chain dehydrogenases/reductases (SDR).", "Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.", "The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.", "Lysine biosynthesis in Saccharom...

[ 1995, 2001, 2000, 1999, 2003, 2003, 2008, 2008, 2010, 2009, 2009 ]

11

[ "IPR013120" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 5636, 4826, 2, 8 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Domain

Thioester reductase-like domain

Thioester_reductase-like_dom

9

IPR010081

10,081

Diaminopropionate ammonia-lyase

DiNH2opropionate_NH3_lyase

Family

3,081

false

This small family includes diaminopropionate ammonia-lyase from Salmonella typhimurium [ ] and a small number of close homologues, about 50 % identical in sequence. The enzyme is a pyridoxal phosphate-binding homodimer homologous to threonine dehydratase (threonine deaminase).

[ "GO:0008838", "GO:0030170" ]

[ "diaminopropionate ammonia-lyase activity", "pyridoxal phosphate binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01747" ]

[ "diampropi_NH3ly" ]

[ 3081 ]

1

[ "EC" ]

[ "4.3.1.15" ]

[ "EC:4.3.1.15" ]

1

[ "4d9g", "4d9i", "4d9k", "4d9m", "4d9n", "5ygr" ]

6

[ "PUB00013480" ]

[ "3275662" ]

[ "Diaminopropionate ammonia-lyase from Salmonella typhimurium. Purification and characterization of the crystalline enzyme, and sequence determination of the pyridoxal 5'-phosphate binding peptide." ]

[ 1988 ]

1

[]

[ "IPR019871" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4, 3026, 22, 29 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Diaminopropionate ammonia-lyase

DiNH2opropionate_NH3_lyase

2

IPR010083

10,083

Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA

FabA

Family

6,690

false

This enzyme, FabA, shows overlapping substrate specificity with FabZ with regard to chain length in fatty acid biosynthesis. It is commonly designated 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase as if it were specific for that chain length, but its specificity is broader; it is active even in the initiation of...

[ "GO:0019171", "GO:0006633", "GO:0005737" ]

[ "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "fatty acid biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00405", "TIGR01749", "cd01287" ]

[ "FabA", "fabA", "FabA" ]

[ 4794, 6087, 5735 ]

3

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.1.59", "5.3.3.14", "GenProp0681", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6282", "PWY-6519", "PWY-7388", "PWY-7663", "PWY-7664", "PWY-7858", "PWY-8173", "PWY-8174", "PWY-8175", "PWY-8203", "PWY-8279", "PWY-8280", "PWY-8427", "PWYG-321" ]

[ "EC:4.2.1.59", "EC:5.3.3.14", "GP:GenProp0681", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989", "METACYC:PWY-6282", "METACYC:PWY-6519", "METACYC:PWY-7388", "METACYC:PWY-7663", "METACYC:PWY-7664", "METACYC:PWY-7858", "METACYC:PWY-8173", "METACYC:PWY-8174", "METACYC:PWY-8175", ...

20

[ "1mka", "1mkb", "2cf2", "3q62", "4b0b", "4b0c", "4b0i", "4b0j", "4b8u", "4cl6", "4fq9", "4keh", "5f6r", "5hd6", "6b7j", "7bhj", "7bis", "7bk9", "7bka", "8b72" ]

20

[ "PUB00005275" ]

[ "8805534" ]

[ "Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site." ]

[ 1996 ]

1

[ "IPR013114" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6554, 20, 116 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA

FabA

6