LiteFold/InterPro · Datasets at Hugging Face

IPR009588

9,588

Feline immunodeficiency virus, Orf3

FIV_Orf3

Family

8

false

This family consists of several hypothetical Feline immunodeficiency virus (FIV) proteins. Members of this family are typically around 67 residues long and are often annotated as ORF3 proteins. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06712" ]

[ "DUF1199" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Feline immunodeficiency virus" ]

[ 8 ]

1

[]

0

true

Family

Feline immunodeficiency virus, Orf3

FIV_Orf3

3

IPR009589

9,589

Uncharacterized protein YyaB-like, PH domain

PH_YyaB-like

Domain

2,459

false

This entry represents the PH domain found in several uncharacterised proteins mainly from bacteroidetes and Bacillus species, whose function is unknown [ ].

[ "GO:0030153" ]

[ "bacteriocin immunity" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06713" ]

[ "bPH_4" ]

[ 2459 ]

1

[]

0

[]

0

[ "PUB00054230", "PUB00077111" ]

[ "19913036", "19047653" ]

[ "Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.", "Immunity to the bacteriocin sublancin 168 Is determined by the SunI (YolF) protein of Bacillus subtilis." ]

[ 2010, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 2440, 2, 6, 11 ]

4

[]

0

true

Domain

Uncharacterized protein YyaB-like, PH domain

PH_YyaB-like

6

IPR009590

9,590

Protein Gp5, N-terminal OB-fold domain

Gp5_OB_N

Domain

543

false

This domain is found at the N-terminal of the Gp5 baseplate protein of Bacteriophage T4. The baseplate is located at the end of the phage tail. Gp5 is a lysozyme essential for localised hydrolysis of bacterial cell walls, which is necessary for viral DNA injection [ ]. This domain binds to the Gp27 protein [ ]. It has ...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06714" ]

[ "Gp5_OB" ]

[ 543 ]

1

[]

0

[ "1k28", "1pdl", "1wth", "2z6b", "5iv5", "9f4a", "9f4b" ]

7

[ "PUB00012803", "PUB00064575" ]

[ "11823865", "12837775" ]

[ "Structure of the cell-puncturing device of bacteriophage T4.", "Homotrimeric, beta-stranded viral adhesins and tail proteins." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Pseudomonadati", "Viruses", "metagenomes" ]

[ 2, 508, 33 ]

3

[]

0

true

Domain

Protein Gp5, N-terminal OB-fold domain

Gp5_OB_N

3

IPR009591

9,591

Movement protein p6, Beet yellows virus

Beet_yellows_virus_p6

Family

12

false

Movement proteins (MPs) encoded by many virus genera are specialised proteins essential for plant viral genomes or virions transport within and between cells. There are some models of virus movement, such as Tobacco mosaic virus (TMV) model or the one described in several families of the icosahedral RNA viruses and par...

[]

0

[ "PFAM" ]

[ "PF06716" ]

[ "MP_p6" ]

[ 12 ]

1

[]

0

[]

0

[ "PUB00094403" ]

[ "15016890" ]

[ "Movement protein of a closterovirus is a type III integral transmembrane protein localized to the endoplasmic reticulum." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Closterovirus", "Glossina austeni" ]

[ 2, 9, 1 ]

3

[]

0

true

Family

Movement protein p6, Beet yellows virus

Beet_yellows_virus_p6

3

IPR009592

9,592

Protein of unknown function DUF1202

DUF1202

Family

1,197

false

This family consists of several hypothetical bacterial proteins of around 335 residues in length. Members of this family are found exclusively in Escherichia coli and Salmonella species and are often referred to as YggM proteins. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06717" ]

[ "DUF1202" ]

[ 1197 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1196, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1202

DUF1202

6

IPR009593

9,593

Protein of unknown function DUF1203

DUF1203

Family

2,555

false

This family consists of several hypothetical bacterial proteins of around 155 residues in length. Family members are present in Rhizobium, Agrobacterium and Streptomyces species.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06718", "PIRSF034110" ]

[ "DUF1203", "DUF1203" ]

[ 2555, 2312 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2466, 80, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF1203

DUF1203

6

IPR009595

9,595

Bacteriophage DNA replication protein Gp16.7

Phage_DNA_replic_GP16.7

Family

44

false

The early-expressed gene 16.7 is conserved in bacteriophage phi-29 and related phages. It encodes a membrane protein, GP16.7, consisting of an N-terminal transmembrane domain and a C-terminal DNA-binding and dimerisation domain. GP16.7 plays an important role in organising membrane-associated bacteriophage DNA replicat...

[ "GO:0039693" ]

[ "viral DNA genome replication" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06720" ]

[ "Phi-29_GP16_7" ]

[ 44 ]

1

[]

0

[ "1zae", "2bnk", "2c5r" ]

3

[ "PUB00038816", "PUB00056221", "PUB00056222" ]

[ "15772069", "10921898", "11169113" ]

[ "Structure of the functional domain of phi29 replication organizer: insights into oligomerization and dna binding.", "Dynamic relocalization of phage phi 29 DNA during replication and the role of the viral protein p16.7.", "Characterization of the bacteriophage phi29-encoded protein p16.7: a membrane protein in...

[ 2005, 2000, 2001 ]

3

[]

0

null

[ "Aliicoccus persicus", "Salasmaviridae" ]

[ 1, 43 ]

2

[]

0

true

Family

Bacteriophage DNA replication protein Gp16.7

Phage_DNA_replic_GP16.7

7

IPR009597

9,597

Domain of unknown function DUF1206

DUF1206

Domain

5,687

false

This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.

[]

0

[ "PFAM" ]

[ "PF06724" ]

[ "DUF1206" ]

[ 5687 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5576, 93, 18 ]

3

[]

0

true

Domain

Domain of unknown function DUF1206

DUF1206

1

IPR009598

9,598

Apoptosis inducing factor BLCAP

BCALP

Family

2,208

false

This family consists of a series of short proteins of around 90 residues in length which includes Apoptosis inducing factor BLCAP from human ( ), also known as BC10. BCALP acts as a tumor suppressor; it induces growth arrest at G1/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mec...

[]

0

[ "PANTHER", "SMART" ]

[ "PTHR13259", "SM01396" ]

[ "", "BC10" ]

[ 2152, 2200 ]

2

[]

0

[]

0

[ "PUB00012807", "PUB00044678", "PUB00153763", "PUB00153764", "PUB00153765", "PUB00153766" ]

[ "11920613", "15797904", "16675915", "17031575", "21844121", "26986503" ]

[ "bc10: A novel human bladder cancer-associated protein with a conserved genomic structure downregulated in invasive cancer.", "A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10.", "Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor ...

[ 2002, 2005, 2006, 2007, 2011, 2016 ]

6

[]

0

null

[ "Opisthokonta" ]

[ 2208 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 3, 1, 1, 2, 1 ]

8

true

Family

Apoptosis inducing factor BLCAP

BCALP

9

IPR009599

9,599

Protein of unknown function DUF1207

DUF1207

Family

364

false

This family consists of a number of hypothetical bacterial proteins of around 410 residues in length, which seem to be specific to Chlamydia species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06727" ]

[ "DUF1207" ]

[ 364 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "unclassified sequences" ]

[ 354, 3, 7 ]

3

[]

0

true

Family

Protein of unknown function DUF1207

DUF1207

5

IPR009600

9,600

GPI transamidase subunit PIG-U

PIG-U

Family

4,944

false

Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the C terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subuni...

[ "GO:0016255", "GO:0016020", "GO:0042765" ]

[ "attachment of GPI anchor to protein", "membrane", "GPI-anchor transamidase complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06728", "PTHR13121" ]

[ "PIG-U", "" ]

[ 4938, 4766 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162791", "R-MMU-162791", "R-RNO-162791" ]

[ "REACTOME:R-HSA-162791", "REACTOME:R-MMU-162791", "REACTOME:R-RNO-162791" ]

3

[ "7w72", "7wld", "8imx", "8imy" ]

4

[ "PUB00012808" ]

[ "12802054" ]

[ "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati" ]

[ 19, 4921, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 1, 2, 1, 3, 3, 1, 6, 7, 1, 1, 15 ]

12

true

Family

GPI transamidase subunit PIG-U

PIG-U

4

IPR009601

9,601

Centromere protein R

CENP-R

Family

783

false

Centromere protein R (CENP-R, also known as NRIF3) is a transcription co-regulator that can have both co-activator and co-repressor functions [ , ]. It is involved in the co-activation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion [ , ]. It is a probable component of...

[ "GO:0006355", "GO:0034080" ]

[ "regulation of DNA-templated transcription", "CENP-A containing chromatin assembly" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06729", "PIRSF011860", "PTHR15581" ]

[ "CENP-R", "NRIF3_coact_rcpt", "" ]

[ 778, 300, 781 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-141444", "R-HSA-205043", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-205043", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-606279", "R-MMU-68877", "R-MMU-9648025", "R-RNO-141444", "R-R...

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-205043", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-606279", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-205043", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU...

24

[ "7pb8", "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh" ]

9

[ "PUB00012809", "PUB00044194", "PUB00066731", "PUB00066732", "PUB00066733" ]

[ "11713274", "16622419", "10490654", "12244126", "15254226" ]

[ "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.", "The human CENP-A centromeric nucleosome-associated complex.", "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors.", "Role of beta(3)-endonexin in the r...

[ 2001, 2006, 1999, 2002, 2004 ]

5

[]

0

null

[ "Gnathostomata" ]

[ 783 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 2, 10 ]

4

true

Family

Centromere protein R

CENP-R

2

IPR009602

9,602

CBY1-interacting BAR domain-containing protein/FAM92

CBAR/FAM92

Family

2,658

false

This entry represents a group of CBY1-interacting BAR domain-containing proteins formerly known as FAM92. Proteins in this family have a role in embryogenesis, being essential for ectoderm and axial mesoderm development [ ]. They may regulate cell proliferation and apoptosis [ ]. During spermatogenesis, these proteins ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06730", "PTHR21223" ]

[ "FAM92", "" ]

[ 2610, 2602 ]

2

[]

0

[ "8ceg", "9uhd" ]

2

[ "PUB00057417", "PUB00057418", "PUB00085188", "PUB00097911", "PUB00097912", "PUB00100315" ]

[ "17440976", "17646714", "27528616", "30395363", "31821146", "33370260" ]

[ "Isolation and characterization of a novel Xenopus gene (xVAP019) encoding a DUF1208 domain containing protein.", "Identification and characterization of two novel variants of the DUF1208 protein FAM92A1.", "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.", "FAM92A Under...

[ 2007, 2007, 2016, 2019, 2019, 2020 ]

6

[]

0

null

[ "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "marine sediment metagenome" ]

[ 1, 2652, 5 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 14, 9, 9 ]

5

true

Family

CBY1-interacting BAR domain-containing protein/FAM92

CBAR/FAM92

3

IPR009604

9,604

LsmAD domain

LsmAD_domain

Domain

8,299

false

This domain can be found in eukaryotic ataxin-2 [ ]. Ataxin-2 is predicted to consist of mostly non-globular domains [ ]. This domain has been shown to interact with RNA helicase DDX6 [ ]. Ataxin-2 has many functions, such as endocytic receptor cycling [ ], translational regulation, embryonic development [ ], energy me...

[]

0

[ "PFAM", "SMART" ]

[ "PF06741", "SM01272" ]

[ "LsmAD", "LsmAD" ]

[ 8186, 8282 ]

2

[]

0

[]

0

[ "PUB00012814", "PUB00044761", "PUB00065004", "PUB00077680", "PUB00077681", "PUB00077682", "PUB00077683", "PUB00077684", "PUB00086748", "PUB00095159", "PUB00095160", "PUB00095161", "PUB00095162", "PUB00095163" ]

[ "9462862", "16115810", "17392519", "18602463", "8896555", "25902068", "15342467", "16293225", "15082763", "29427103", "9819425", "15121841", "30982600", "18981231" ]

[ "Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain.", "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.", "Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodie...

[ 1998, 2005, 2007, 2008, 1996, 2015, 2004, 2006, 2004, 2018, 1998, 2004, 2019, 2008 ]

14

[]

0

null

[ "Eukaryota" ]

[ 8299 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 35, 2, 21, 11, 1, 3, 19, 1, 1, 33 ]

12

true

Domain

LsmAD domain

LsmAD_domain

2

IPR009606

9,606

DESIGUAL/Modifying wall lignin-1/2

DEAL/Modifying_wall_lignin1/2

Family

8,134

false

This entry represents a group of proteins from Streptophytes, including Protein VASCULATURE COMPLEXITY AND CONNECTIVITY (also known as DEAL1), Protein DESIGUAL 2-4 (DEAL2-4) and Protein MODIFYING WALL LIGNIN-1/2 (MWL-1/2). DEAL1 is required for embryo provasculature development and cotyledon vascular complexity and con...

[]

0

[ "PFAM" ]

[ "PF06749" ]

[ "DUF1218" ]

[ 8134 ]

1

[]

0

[]

0

[ "PUB00092870", "PUB00100316", "PUB00100317" ]

[ "26930070", "29139551", "25149602" ]

[ "The Arabidopsis Domain of Unknown Function 1218 (DUF1218) Containing Proteins, MODIFYING WALL LIGNIN-1 and 2 (At1g31720/MWL-1 and At4g19370/MWL-2) Function Redundantly to Alter Secondary Cell Wall Lignin Content.", "Members of the DEAL subfamily of the DUF1218 gene family are required for bilateral symmetry but ...

[ 2016, 2018, 2014 ]

3

[]

0

null

[ "Alkalicoccobacillus murimartini", "Eukaryota" ]

[ 1, 8133 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 61, 56, 54 ]

3

true

Family

DESIGUAL/Modifying wall lignin-1/2

DEAL/Modifying_wall_lignin1/2

7

IPR009607

9,607

Enhancer of polycomb, C-terminal

Enhancer_polycomb_C

Domain

2,577

false

This entry represents the C terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation [ ].

[]

0

[ "PFAM" ]

[ "PF06752" ]

[ "E_Pc_C" ]

[ 2577 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3214847", "R-HSA-8953750", "R-MMU-8953750" ]

[ "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-8953750", "REACTOME:R-MMU-8953750" ]

3

[ "6nfx", "8qr1", "8xvg", "8xvt", "9c57", "9c62", "9c6n", "9cac", "9cae" ]

9

[ "PUB00012820" ]

[ "9735366" ]

[ "The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals." ]

[ 1998 ]

1

[]

0

null

[ "Bilateria" ]

[ 2577 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 4, 5, 8 ]

4

true

Domain

Enhancer of polycomb, C-terminal

Enhancer_polycomb_C

9

IPR009608

9,608

Bradykinin

Family

16

false

This family consists of several Bradykinin sequences. The skins of anuran amphibians, in addition to mucus glands, contain highly specialised poison glands, which, in reaction to stress or attack, exude a complex noxious cocktail of biologically active molecules. These secretions often contain a plethora of peptides am...

[ "GO:0005179", "GO:0006952", "GO:0035821", "GO:0005576" ]

[ "hormone activity", "defense response", "modulation of process of another organism", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06753" ]

[ "Bradykinin" ]

[ 16 ]

1

[]

0

[]

0

[ "PUB00012821", "PUB00099770", "PUB00099771" ]

[ "12230583", "29571654", "25793726" ]

[ "Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin.", "The anuran skin peptide bradykinin mediates its own absorption across epithelial barriers of the digestive tract.", "A review on bradykinin-related peptides isolated from amphibian skin secretion." ]

[ 2002, 2018, 2015 ]

3

[]

0

null

[ "Bilateria" ]

[ 16 ]

1

[]

0

true

Family

Bradykinin

5

IPR009609

9,609

Phosphonate metabolism PhnG

Phosphonate_metab_PhnG

Family

3,874

false

This family consists of several bacterial phosphonate metabolism protein PhnG sequences. In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The exact function of PhnG is unknown, however it is thought likely that along with six other proteins PhnG makes up the...

[ "GO:0015716", "GO:0019634" ]

[ "organic phosphonate transport", "organic phosphonate metabolic process" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF06754", "TIGR03293" ]

[ "PhnG", "PhnG_redo" ]

[ 3874, 3635 ]

2

[ "GP", "GP", "GP", "GP" ]

[ "GenProp0232", "GenProp1165", "GenProp1381", "GenProp1630" ]

[ "GP:GenProp0232", "GP:GenProp1165", "GP:GenProp1381", "GP:GenProp1630" ]

4

[ "4xb6", "7z15", "7z16", "7z17", "7z18", "7z19" ]

6

[ "PUB00012822" ]

[ "9882650" ]

[ "Rhizobium (Sinorhizobium) meliloti phn genes: characterization and identification of their protein products." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 3820, 4, 34, 16 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphonate metabolism PhnG

Phosphonate_metab_PhnG

9

IPR009612

9,612

IcmF-related

IcmF-rel

Domain

8,899

false

This entry represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed [ ] to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many entry members are hypothetica...

[]

0

[ "PFAM" ]

[ "PF06761" ]

[ "IcmF-related" ]

[ 8899 ]

1

[]

0

[ "6hs7", "6ixh" ]

2

[ "PUB00012816", "PUB00093973", "PUB00151684" ]

[ "12127983", "31379775", "26200339" ]

[ "Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency.", "Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.", "Biogenesis and structure of a type VI secretion membrane core complex." ]

[ 2002, 2019, 2015 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8835, 14, 50 ]

3

[]

0

true

Domain

IcmF-related

IcmF-rel

1

IPR009613

9,613

Lipase maturation factor

LMF

Family

6,237

false

This family of transmembrane proteins includes the lipase maturation factors LMF1 and LMF2. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [ ]. LMF1 acts as a specific chaperone for dimeric lipases, required both for maturation and transport of active lipoprotein lipase (LPL) throug...

[ "GO:0051604" ]

[ "protein maturation" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR14463" ]

[ "" ]

[ 6237 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8963889", "R-MMU-8963889", "R-RNO-8963889", "R-XTR-8963889" ]

[ "REACTOME:R-HSA-8963889", "REACTOME:R-MMU-8963889", "REACTOME:R-RNO-8963889", "REACTOME:R-XTR-8963889" ]

4

[]

0

[ "PUB00057509", "PUB00057511", "PUB00098585" ]

[ "17994020", "20543905", "24909692" ]

[ "Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.", "Mechanisms of lipase maturation.", "Purification, cellular levels, and functional domains of lipase maturation factor 1." ]

[ 2007, 2010, 2014 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 61, 2117, 4030, 29 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 12, 6, 7 ]

5

true

Family

Lipase maturation factor

LMF

3

IPR009614

9,614

Toxin YoeB

YoeB_toxin

Family

8,101

false

This is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in . The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively qu...

[ "GO:0004519", "GO:0006401" ]

[ "endonuclease activity", "RNA catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF06769", "PTHR38039", "TIGR02116" ]

[ "YoeB_toxin", "", "toxin_Txe_YoeB" ]

[ 8016, 7713, 7735 ]

3

[ "GP", "GP" ]

[ "GenProp0321", "GenProp1133" ]

[ "GP:GenProp0321", "GP:GenProp1133" ]

2

[ "2a6q", "2a6r", "2a6s", "3oei", "4v8x", "6l8e", "6l8f", "6l8g", "6n90", "6ny6", "6otr", "6oxa", "6oxi", "7bwf", "7cua", "7v5y", "7v5z", "7v6w", "8yxv" ]

19

[ "PUB00015566", "PUB00075545", "PUB00075546" ]

[ "12603745", "17170003", "19124462" ]

[ "Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium.", "Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression.", "The inhibitory mechanism of protein synthe...

[ 2003, 2007, 2009 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanimicrococcus", "Opisthokonta", "unclassified sequences" ]

[ 7928, 4, 2, 14, 153 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Toxin YoeB

YoeB_toxin

2

IPR009615

9,615

Viral desmoplakin, N-terminal

Desmo_N

Domain

188

false

This entry represents the N terminus of viral desmoplakin. Desmoplakin is a component of mature desmosomes, which are the main adhesive junctions in epithelia and cardiac muscle. Desmoplakin is also essential for the maturation of adherens junctions [ ]. Note that many family members are hypothetical.

[]

0

[ "PFAM" ]

[ "PF06771" ]

[ "Desmo_N" ]

[ 188 ]

1

[]

0

[ "9h2j", "9h2k" ]

2

[ "PUB00012832" ]

[ "11781580" ]

[ "Deconstructing desmoplakin." ]

[ 2001 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 188 ]

1

[]

0

true

Domain

Viral desmoplakin, N-terminal

Desmo_N

9

IPR009617

9,617

Seipin

Family

5,388

false

This entry represents Seipin found in mammals. This entry also includes Seipin homologues from fission yeasts and plants. There are three SEIPIN homologues in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3. Similar to their animal homologues, plant and yeast Seipins also play roles in lipid droplet (LD)...

[ "GO:0019915" ]

[ "lipid storage" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06775", "PTHR21212" ]

[ "Seipin", "" ]

[ 5365, 4871 ]

2

[]

0

[ "6ds5", "6mlu", "9c8d", "9c8e" ]

4

[ "PUB00044745", "PUB00077089", "PUB00077090" ]

[ "11479539", "22269949", "26362606" ]

[ "Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.", "Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation.", "Arabidopsis SEIPIN Proteins Modulate Triacylglycerol Accumulation ...

[ 2001, 2012, 2015 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5388 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 12, 1, 11, 1, 21, 4, 1, 6, 6, 1, 9 ]

11

true

Family

Seipin

1

IPR009619

9,619

Cell division protein CrgA

CrgA

Family

4,577

false

CrgA is a transmembrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mycobacterium tuberculosis, CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_00631", "PF06781" ]

[ "CrgA", "CrgA" ]

[ 4448, 4577 ]

2

[]

0

[ "2mmu", "9nm2" ]

2

[ "PUB00081940" ]

[ "25548160" ]

[ "Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Candidatus Nitrosomaritimum aestuariumsis", "Halteria grandinella", "metagenomes" ]

[ 4435, 1, 1, 140 ]

4

[]

0

true

Family

Cell division protein CrgA

CrgA

9

IPR009620

9,620

Uncharacterised protein family UPF0236

UPF0236

Family

2,431

false

This entry represents a family of bacterial proteins of unknown function. Some family members are thought to be transposases [ ].

[]

0

[ "PFAM" ]

[ "PF06782" ]

[ "UPF0236" ]

[ 2431 ]

1

[]

0

[]

0

[ "PUB00101018" ]

[ "26779141" ]

[ "New Insights into the Classification and Integration Specificity of Streptococcus Integrative Conjugative Elements through Extensive Genome Exploration." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "Trichuris trichiura", "metagenomes" ]

[ 2367, 15, 1, 48 ]

4

[]

0

true

Family

Uncharacterised protein family UPF0236

UPF0236

7

IPR009622

9,622

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

NDUFAF4

Family

1,707

false

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4, also known as HRPAP20) is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) [ ]. It may be involved in cell proliferation and survival of hormone-dependent tumor cells [ ].

[ "GO:0032981" ]

[ "mitochondrial respiratory chain complex I assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06784", "PTHR13338" ]

[ "UPF0240", "" ]

[ 1683, 1490 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6799198", "R-CEL-6799198", "R-DME-6799198", "R-HSA-6799198", "R-MMU-6799198", "R-RNO-6799198" ]

[ "REACTOME:R-BTA-6799198", "REACTOME:R-CEL-6799198", "REACTOME:R-DME-6799198", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-6799198" ]

6

[]

0

[ "PUB00067986", "PUB00067987" ]

[ "14871833", "17001319" ]

[ "Identification of HRPAP20: a novel phosphoprotein that enhances growth and survival in hormone-responsive tumor cells.", "HRPAP20: a novel calmodulin-binding protein that increases breast cancer cell invasion." ]

[ 2004, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1707 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 3, 4 ]

6

true

Family

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

NDUFAF4

5

IPR009623

9,623

UPF0242, N-terminal

UPF0242_N

Domain

47

false

This region includes an N-terminal transmembrane region and a C-terminal coiled-coil.

[]

0

[ "PFAM" ]

[ "PF06785" ]

[ "UPF0242" ]

[ 47 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Diptera" ]

[ 43, 4 ]

2

[]

0

true

Domain

UPF0242, N-terminal

UPF0242_N

6

IPR009624

9,624

Uncharacterised protein family UPF0253

UPF0253

Family

1,282

false

This is a group of proteins of unknown function.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01064", "NF003436", "PF06786" ]

[ "UPF0253", "PRK04964.1", "UPF0253" ]

[ 1190, 1260, 1282 ]

3

[]

0

[ "5h1n" ]

1

[]

0

[]

0

null

[ "Bacteria", "Bracon brevicornis" ]

[ 1281, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0253

UPF0253

2

IPR009625

9,625

FeGP cofactor biosynthesis protein HcgF

HcgF

Family

85

false

This archaeal family includes the iron guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF which catalyses the transesterification of AMP-GP to afford a Cys (HcgF)-S-GP thioester [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_00673", "NF002122", "PF06787", "PIRSF018786" ]

[ "UPF0254", "PRK00962.1", "HcgF", "UPF0254" ]

[ 79, 81, 85, 19 ]

4

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

219

[ "3wva", "3wvb", "3wvc" ]

3

[ "PUB00098596" ]

[ "25882909" ]

[ "Protein-pyridinol thioester precursor for biosynthesis of the organometallic acyl-iron ligand in [Fe]-hydrogenase cofactor." ]

[ 2015 ]

1

[]

0

null

[ "Desulfurobacterium", "Methanobacteriota", "bioreactor metagenome" ]

[ 4, 80, 1 ]

3

[]

0

true

Family

FeGP cofactor biosynthesis protein HcgF

HcgF

5

IPR009626

9,626

Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal

MINAR1-like_C

Domain

1,825

false

MINAR1 is a Notch2-binding protein that has been shown to inhibit angiogenesis and breast cancer growth [ ]. This entry represents the C terminus of the MINAR1 protein.

[]

0

[ "PFAM" ]

[ "PF06789" ]

[ "MINAR1_C" ]

[ 1825 ]

1

[]

0

[]

0

[ "PUB00089813" ]

[ "29329397" ]

[ "MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth." ]

[ 2018 ]

1

[]

0

null

[ "Bilateria" ]

[ 1825 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 3, 4, 12 ]

4

true

Domain

Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal

MINAR1-like_C

6

IPR009627

9,627

Uncharacterised protein family UPF0259

UPF0259

Family

1,322

false

This is a group of membrane proteins of unknown function.

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01067", "NF002774" ]

[ "UPF0259", "PRK02868.1" ]

[ 1310, 1230 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1320, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0259

UPF0259

5

IPR009628

9,628

Bacteriophage tail tape measure, N-terminal

Phage_tape_measure_N

Domain

4,011

false

This entry represents a conserved region located towards the N-terminal end of prophage tail length tape measure protein (TMP). TMP is important for assembly of phage tails and involved in tail length determination. Mutated forms TMP cause tail fibres to be shortened [ ]. The characteristics of the protein distribution...

[]

0

[ "PFAM" ]

[ "PF06791" ]

[ "TMP_2" ]

[ 4011 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "8iyk", "8iyl", "8k35", "9l9p" ]

4

[ "PUB00010241" ]

[ "11040123" ]

[ "Mutational analysis of two structural genes of the temperate lactococcal bacteriophage TP901-1 involved in tail length determination and baseplate assembly." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Natrarchaeobaculum sulfurireducens", "Viruses", "metagenomes" ]

[ 3551, 7, 1, 430, 22 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Bacteriophage tail tape measure, N-terminal

Phage_tape_measure_N

9

IPR009629

9,629

Erythrovirus X

Erythrovirus_X

Family

38

false

This family consists of several Erythrovirus X proteins, which seem to be found exclusively in human parvovirus and human erythrovirus. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06795" ]

[ "Erythrovirus_X" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Erythroparvovirus" ]

[ 38 ]

1

[]

0

true

Family

Erythrovirus X

Erythrovirus_X

3

IPR009630

9,630

Protein of unknown function DUF1229

DUF1229

Family

108

false

This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira.

[]

0

[ "PFAM" ]

[ "PF06797" ]

[ "DUF1229" ]

[ 108 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 108 ]

1

[]

0

true

Family

Protein of unknown function DUF1229

DUF1229

2

IPR009631

9,631

CGLD27-like

Family

1,879

false

This family consist of proteins found in plants and algal chloroplasts, and in cyanobacteria. It includes CGLD27 (CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27), which has been described as one out of 14 Fe-responsive orthologues in Chlamydomonas and Arabidopsis, indicating that it is an important component of the iron...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06799", "PTHR34214" ]

[ "CGLD27-like", "" ]

[ 1860, 1825 ]

2

[]

0

[]

0

[ "PUB00086879" ]

[ "23043051" ]

[ "Systems and trans-system level analysis identifies conserved iron deficiency responses in the plant lineage." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 363, 1516 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 6, 9 ]

3

true

Family

CGLD27-like

3

IPR009633

9,633

Vaccinia virus, B17

Vaccinia_virus_B17

Family

93

false

This family consists of several Orthopoxvirus specific proteins predominantly of around 340 residues in length. This family contains the Vaccinia virus, B17 protein, the function of which is unknown.

[]

0

[ "PFAM" ]

[ "PF06802" ]

[ "DUF1231" ]

[ 93 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chordopoxvirinae", "Perkinsus chesapeaki" ]

[ 92, 1 ]

2

[]

0

true

Family

Vaccinia virus, B17

Vaccinia_virus_B17

8

IPR009634

9,634

Rac prophage excisionase XisR

XisR

Family

1,214

false

This entry represents XisR, an excisionase that induces excision of the Rac prophage, a cryptic prophage harbouring several genes with important physiological functions. XisR binds to and shifts the right attachment site of Rac, facilitating prophage excision [ ].

[]

0

[ "PFAM" ]

[ "PF06806" ]

[ "DUF1233" ]

[ 1214 ]

1

[]

0

[ "2kvv" ]

1

[ "PUB00159858" ]

[ "26530864" ]

[ "Physiological Function of Rac Prophage During Biofilm Formation and Regulation of Rac Excision in Escherichia coli K-12." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Viruses", "unclassified sequences" ]

[ 1160, 50, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Rac prophage excisionase XisR

XisR

5

IPR009635

9,635

Neural proliferation differentiation control-1

NPDC1

Family

2,104

false

This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differentiation. It has been suggested that NPDC1 may be involved in the development of several secretion glands. This family also contains the C-terminal r...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06809", "PTHR23352" ]

[ "NPDC1", "" ]

[ 2092, 2041 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-198933", "R-MMU-198933" ]

[ "REACTOME:R-HSA-198933", "REACTOME:R-MMU-198933" ]

2

[]

0

[ "PUB00012844" ]

[ "10970871" ]

[ "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission." ]

[ 2000 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 2104 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 3, 4, 7, 8 ]

6

true

Family

Neural proliferation differentiation control-1

NPDC1

9

IPR009636

9,636

Capsid assembly scaffolding protein

SCAF

Family

2,113

false

This entry consists of several phage scaffolding proteins involved in the icosahedric procapsid assembly [ ]. They co-assemble with the capsid proteins to form the procapsid, in which the scaffolding protein is found within the external shell of icosahedrally arranged capsid protein subunits. In a subsequent step the s...

[ "GO:0019069" ]

[ "viral capsid assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06810" ]

[ "Phage_scaffold" ]

[ 2113 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00080982", "PUB00080983" ]

[ "22514336", "18377930" ]

[ "Capsid structure and its stability at the late stages of bacteriophage SPP1 assembly.", "Oligomerization of the SPP1 scaffolding protein." ]

[ 2012, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "metagenomes" ]

[ 1694, 2, 1, 392, 24 ]

5

[]

0

true

Family

Capsid assembly scaffolding protein

SCAF

8

IPR009637

9,637

Transmembrane protein GPR107/GPR108-like

GPR107/GPR108-like

Family

13,130

false

This entry represents a group of transmembrane proteins, including mammalian GPR107, GPR108, TMEM87A and TMEM87B which have been collectively termed lung seven transmembrane receptor or LUSTR and are evolutionary related. Together with GPR180, TMEM145, TMEM181, and WLS, they have been described as GOST proteins (for GO...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR21229" ]

[ "" ]

[ 13130 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8980692", "R-MMU-8980692" ]

[ "REACTOME:R-HSA-8980692", "REACTOME:R-MMU-8980692" ]

2

[ "8ctj", "8hsi", "8htt", "8kb4" ]

4

[ "PUB00077130", "PUB00077131", "PUB00093391", "PUB00151072", "PUB00151073", "PUB00151074", "PUB00151075", "PUB00151076" ]

[ "25031321", "17454009", "18671868", "36373655", "30332431", "31784416", "24849652", "32280726" ]

[ "GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.", "Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled recept...

[ 2014, 2007, 2008, 2022, 2018, 2020, 2014, 2020 ]

8

[]

0

null

[ "Eukaryota" ]

[ 13130 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 39, 2, 13, 2, 30, 13, 1, 29, 14, 2, 2, 71 ]

12

true

Family

Transmembrane protein GPR107/GPR108-like

GPR107/GPR108-like

6

IPR009640

9,640

Bacteriophage 933W, L0121, tail fibre, C-terminal

Phage_933W_L0121_C

Domain

729

false

This entry represents the C terminus of phage 933W tail fibre protein. This domain is found together with conserved RLGP motif. The characteristics of the protein distribution suggest prophage matches.

[]

0

[ "PFAM" ]

[ "PF06820" ]

[ "Phage_fiber_C" ]

[ 729 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Enterobacteriaceae" ]

[ 114, 615 ]

2

[]

0

true

Domain

Bacteriophage 933W, L0121, tail fibre, C-terminal

Phage_933W_L0121_C

5

IPR009641

9,641

Vaccinia virus, A37

Vaccinia_virus_A37

Family

159

false

This family contains a number of poxviral proteins, which include Vaccinia virus A37, also known as Protein OPG165, the function of which is unknown.

[]

0

[ "PFAM" ]

[ "PF06822" ]

[ "DUF1235" ]

[ 159 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Poxviridae" ]

[ 159 ]

1

[]

0

true

Family

Vaccinia virus, A37

Vaccinia_virus_A37

5

IPR009642

9,642

Protein of unknown function DUF1236

DUF1236

Family

3,252

false

This family contains a number of hypothetical bacterial proteins of unknown function. Some family members contain more than one copy of the region represented by this family.

[]

0

[ "PFAM" ]

[ "PF06823" ]

[ "DUF1236" ]

[ 3252 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pleodorina starrii", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 3245, 6 ]

3

[]

0

true

Family

Protein of unknown function DUF1236

DUF1236

8

IPR009643

9,643

Heat shock factor binding 1

HS1-bd

Family

4,209

false

Heat shock factor binding protein 1 (HSBP1) interacts with the oligomerization domain of heat shock factor 1 (Hsf1), suppressing Hsf1's transcriptional activity following stress. It plays an essential role during early mouse and zebrafish embryonic development [ ]. In the plant Arabidopsis, heat shock factor-binding pr...

[ "GO:0003714" ]

[ "transcription corepressor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06825", "PTHR19424" ]

[ "HSBP1", "" ]

[ 4022, 3621 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3371568", "R-BTA-3371571", "R-HSA-3371511", "R-HSA-3371568", "R-HSA-3371571", "R-MMU-3371568", "R-MMU-3371571", "R-RNO-3371568", "R-RNO-3371571", "R-SPO-3371568", "R-SPO-3371571" ]

[ "REACTOME:R-BTA-3371568", "REACTOME:R-BTA-3371571", "REACTOME:R-HSA-3371511", "REACTOME:R-HSA-3371568", "REACTOME:R-HSA-3371571", "REACTOME:R-MMU-3371568", "REACTOME:R-MMU-3371571", "REACTOME:R-RNO-3371568", "REACTOME:R-RNO-3371571", "REACTOME:R-SPO-3371568", "REACTOME:R-SPO-3371571" ]

11

[ "3ci9" ]

1

[ "PUB00079188", "PUB00089627", "PUB00089628" ]

[ "24380799", "20388662", "20657173" ]

[ "An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.", "Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arab...

[ 2014, 2010, 2010 ]

3

[]

0

null

[ "Chryseobacterium gambrini", "Eukaryota", "Thermofilum pendens" ]

[ 1, 4207, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 3, 5, 4, 2, 1, 4, 5, 1, 7 ]

11

true

Family

Heat shock factor binding 1

HS1-bd

4

IPR009644

9,644

FKTN/Mannosyltransferase regulator

FKTN/MNN-like

Family

4,206

false

This entry covers FKTN protein in mammals and its orthologues in C.elegans (W02B3.4, W02B3.1 and T07A5.1) , yeast (MNN4) and related Mannosyltransferase regulator proteins. Ribitol-5-phosphate transferase (FKTN) is a eukaryotic protein necessary for the maintenance of muscle integrity, cortical histiogenesis, and norma...

[]

0

[ "PANTHER" ]

[ "PTHR15407" ]

[ "" ]

[ 4206 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9939291", "R-MMU-9939291" ]

[ "REACTOME:R-HSA-9939291", "REACTOME:R-MMU-9939291" ]

2

[]

0

[ "PUB00012851", "PUB00044679", "PUB00070173", "PUB00070174", "PUB00098859", "PUB00100318" ]

[ "12783852", "11445638", "9023541", "9459307", "29477842", "26923585" ]

[ "Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development.", "Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy.", "Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Sacchar...

[ 2003, 2001, 1996, 1997, 2018, 2016 ]

6

[]

0

null

[ "Eukaryota", "Pseudomonadati", "Viruses" ]

[ 4195, 8, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 6, 2, 12, 3, 2, 3, 2 ]

7

true

Family

FKTN/Mannosyltransferase regulator

FKTN/MNN-like

6

IPR009645

9,645

Uncharacterised conserved protein GguC

GguC

Family

2,384

false

There is currently no experimental data for members of this family or their homologues. Agrobacterium tumefaciens GguC is encoded by the same operon as ChvE (periplasmic sugar-binding protein that transmits the signal to the VirA/VirG signalling system), GguA and GguB (putative ABC-type sugar transporter components) [ ...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF040903", "PIRSF033905" ]

[ "GguC", "UCP033905" ]

[ 2384, 2317 ]

2

[]

0

[]

0

[ "PUB00027829" ]

[ "11514518" ]

[ "The Brucella suis homologue of the Agrobacterium tumefaciens chromosomal virulence operon chvE is essential for sugar utilization but not for survival in macrophages." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Durusdinium trenchii", "unclassified sequences" ]

[ 2374, 1, 9 ]

3

[]

0

true

Family

Uncharacterised conserved protein GguC

GguC

6

IPR009647

9,647

Penicillin-binding, C-terminal

PBP_C

Domain

8,401

false

This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit ( ). It is predicted to be a β fold.

[]

0

[ "PFAM" ]

[ "PF06832" ]

[ "BiPBP_C" ]

[ 8401 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8344, 7, 50 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Penicillin-binding, C-terminal

PBP_C

6

IPR009648

9,648

Biotin-dependent malonate decarboxylase, gamma subunit

Malonate_gamma

Family

2,530

false

This family consists of several bacterial malonate decarboxylase gamma subunit proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H + to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the pho...

[ "GO:0005975" ]

[ "carbohydrate metabolic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03134" ]

[ "malonate_gamma" ]

[ 2530 ]

1

[ "GP" ]

[ "GenProp0674" ]

[ "GP:GenProp0674" ]

1

[ "5vip", "5vit", "5vj1" ]

3

[ "PUB00012854", "PUB00043059" ]

[ "9208947", "10561613" ]

[ "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli.", "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus." ]

[ 1997, 1999 ]

2

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Opisthokonta", "mine drainage metagenome" ]

[ 2521, 4, 2, 3 ]

4

[]

0

true

Family

Biotin-dependent malonate decarboxylase, gamma subunit

Malonate_gamma

1

IPR009649

9,649

TraU

Family

4,905

false

This family consists of several bacterial TraU proteins. TraU appears to be more essential to conjugal DNA transfer than to assembly of pilus filaments [ ].

[]

0

[ "PFAM" ]

[ "PF06834" ]

[ "TraU" ]

[ 4905 ]

1

[ "GP" ]

[ "GenProp0484" ]

[ "GP:GenProp0484" ]

1

[]

0

[ "PUB00012855" ]

[ "2198250" ]

[ "Characterization of the F-plasmid conjugative transfer gene traU." ]

[ 1990 ]

1

[]

[ "IPR026331" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4839, 27, 39 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TraU

5

IPR009650

9,650

Fijivirus P9-2

Fijivirus_P9-2

Family

58

false

This family consists of several Fijivirus specific P9-2 proteins from Rice black streaked dwarf virus (RBSDV) and Fiji disease virus. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06837" ]

[ "Fijivirus_P9-2" ]

[ 58 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fijivirus", "Kingdonia uniflora" ]

[ 57, 1 ]

2

[]

0

true

Family

Fijivirus P9-2

Fijivirus_P9-2

7

IPR009651

9,651

Putative methionine gamma-lyase

Met_g_lyase_put

Family

5,171

false

This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06838", "PTHR46658" ]

[ "Met_gamma_lyase", "" ]

[ 5166, 5152 ]

2

[]

0

[ "3fd0", "3gwp", "3ht4", "3hvy", "3i16", "3jzl" ]

6

[ "PUB00017592", "PUB00046180" ]

[ "9190812", "9488680" ]

[ "Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida.", "The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes." ]

[ 1997, 1998 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4418, 713, 40 ]

3

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 21 ]

2

true

Family

Putative methionine gamma-lyase

Met_g_lyase_put

3

IPR009652

9,652

Programmed cell death protein 10

PDCD10

Family

2,064

false

Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration [ ]. It also has roles outside of this complex [ ], it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability [ ]. PDCD10/CCM3 was originally discovered to be ...

[]

0

[ "PANTHER" ]

[ "PTHR13250" ]

[ "" ]

[ 2064 ]

1

[]

0

[ "3ajm", "3l8i", "3l8j", "3rqe", "3rqf", "3rqg", "3w8h", "3w8i", "4geh", "4tvq" ]

10

[ "PUB00076417", "PUB00076418", "PUB00076419", "PUB00096889" ]

[ "24595293", "24481819", "20229348", "26490252" ]

[ "Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.", "Cerebral cavernous malformation proteins at a glance.", "cDNA cloning and expression of an apoptosis-related gene, humanTFAR15 gene.", "Downregulation of programmed cell death 10 is associated with tumor cel...

[ 2014, 2014, 1999, 2015 ]

4

[]

0

null

[ "Opisthokonta" ]

[ 2064 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 9, 4, 4 ]

6

true

Family

Programmed cell death protein 10

PDCD10

9

IPR009653

9,653

Protein kish

Ksh1

Family

3,982

false

Protein kish is involved in the early part of the secretory pathway [ ].

[]

0

[ "PFAM" ]

[ "PF06842" ]

[ "DUF1242" ]

[ 3982 ]

1

[]

0

[]

0

[ "PUB00075580" ]

[ "19942856" ]

[ "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway." ]

[ 2010 ]

1

[]

[ "IPR042863" ]

0

1

0

[ "Eukaryota", "bird metagenome" ]

[ 3981, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 3, 2, 3, 3, 1, 4, 7, 1, 1, 5 ]

12

true

Family

Protein kish

Ksh1

7

IPR009656

9,656

PHB de-polymerase, C-terminal

PHB_depo_C

Domain

5,519

false

This entry represents the C terminus of bacterial poly(3-hydroxybutyrate) (PHB) de-polymerase. This degrades PHB granules to oligomers and monomers of 3-hydroxy-butyric acid.

[]

0

[ "PFAM" ]

[ "PF06850" ]

[ "PHB_depo_C" ]

[ 5519 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halocatena salina", "metagenomes" ]

[ 5479, 5, 1, 34 ]

4

[]

0

true

Domain

PHB de-polymerase, C-terminal

PHB_depo_C

2

IPR009657

9,657

Protein Ac34

Protein_Ac34

Family

110

false

Protein Ac34 from Autographa californica nuclear polyhedrosis virus (AcMNPV) induces translocation subunits of the actin nucleator actin-related protein complex Arp2/3 to the nucleus during AcMNPV infection. The Arp2/3 complex regulates actin polymerization and plays a variety of roles during infection, including nucle...

[]

0

[ "PFAM" ]

[ "PF06851" ]

[ "DUF1247" ]

[ 110 ]

1

[]

0

[]

0

[ "PUB00089649" ]

[ "27900558" ]

[ "The role of viral protein Ac34 in nuclear relocation of subunits of the actin-related protein 2/3 complex." ]

[ 2016 ]

1

[]

0

null

[ "Alphabaculovirus" ]

[ 110 ]

1

[]

0

true

Family

Protein Ac34

Protein_Ac34

1

IPR009658

9,658

Domain of unknown function DUF1248

DUF1248

Domain

180

false

This entry represents a conserved region within a number of proteins of unknown function that seem to be specific to Caenorhabditis elegans. Note that some proteins in the entry contain more than one copy of this region. Structurally related to Gcn5-related N-acetyltransferase (GNAT) family.

[]

0

[ "PFAM" ]

[ "PF06852" ]

[ "DUF1248" ]

[ 180 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 180 ]

1

[ "Caenorhabditis elegans" ]

[ 19 ]

1

true

Domain

Domain of unknown function DUF1248

DUF1248

7

IPR009659

9,659

Protein of unknown function DUF1249

DUF1249

Family

3,716

false

This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06853", "PTHR38774" ]

[ "DUF1249", "" ]

[ 3710, 3668 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3657, 6, 53 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1249

DUF1249

8

IPR009660

9,660

Bacteriophage A500, Gp15

Phage_A500_Gp15

Family

1,120

false

This entry describes Gp15 from Bacteriophage A500 (Listeria phage A500), related proteins in other bacteriophage, and prophage regions of bacterial genomes. The function is unknown.

[]

0

[ "PFAM" ]

[ "PF06854" ]

[ "Phage_Gp15" ]

[ 1120 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Tritrichomonas musculus", "Viruses", "bioreactor metagenome" ]

[ 933, 1, 183, 3 ]

4

[]

0

true

Family

Bacteriophage A500, Gp15

Phage_A500_Gp15

3

IPR009661

9,661

Autographa californica nuclear polyhedrosis virus, Da18

AcMNPV_Da18

Family

123

false

This entry is represented by Da18 from Autographa californica nuclear polyhedrosis virus (AcMNPV), also known as Early 18.5 kDa protein. It is a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF06856" ]

[ "AcMNPV_Orf17" ]

[ 123 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses" ]

[ 123 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus, Da18

AcMNPV_Da18

4

IPR009662

9,662

Malonate decarboxylase delta subunit

Malonate_deCO2ase_dsu

Family

2,518

false

This family consists of the acyl carrier protein, also called the delta subunit, of malonate decarboxylase. This subunit has the same covalently bound prosthetic group, derived from and similar to coenzyme A, as does citrate lyase, although this protein and the acyl carrier protein of citrate lyase do not show signific...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00710", "TIGR03130" ]

[ "Malonate_deCO2ase_dsu", "malonate_delta" ]

[ 2518, 2501 ]

2

[ "GP" ]

[ "GenProp0674" ]

[ "GP:GenProp0674" ]

1

[ "5vit", "5vj1" ]

2

[ "PUB00012854" ]

[ "9208947" ]

[ "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli." ]

[ 1997 ]

1

[ "IPR023439" ]

[]

1

0

1

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "metagenomes" ]

[ 2503, 4, 2, 9 ]

4

[]

0

true

Family

Malonate decarboxylase delta subunit

Malonate_deCO2ase_dsu

2

IPR009665

9,665

Spore protease-like YyaC

YyaC

Family

3,195

false

This family consists of a number of proteins conserved among the endospore-forming subset of the firmicutes, which are largely uncharacterised. A member of this entry, called YyaC, shows many similarities to the germination protease GPR, which is found in exactly the same set of organisms and has a known role in the sp...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06866", "TIGR02841" ]

[ "DUF1256", "spore_YyaC" ]

[ 3195, 3150 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[]

0

null

[ "Bacillus phage G", "Bacteria", "metagenomes" ]

[ 1, 3177, 17 ]

3

[]

0

true

Family

Spore protease-like YyaC

YyaC

8

IPR009666

9,666

Uncharacterised protein family Ycf35

Uncharacterised_Ycf35

Family

1,475

false

This family represents Ycf35, which is encoded in algal chloroplast and in cyanobacteria. The function of these proteins are unknown. As the family is exclusively found in phototrophic organisms it may play a role in photosynthesis.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06868", "PTHR39638" ]

[ "DUF1257", "" ]

[ 1475, 1343 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 3, 1075, 6, 378, 13 ]

5

[]

0

true

Family

Uncharacterised protein family Ycf35

Uncharacterised_Ycf35

8

IPR009667

9,667

Protein of unknown function DUF1258

DUF1258

Family

799

false

This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to rotifers, nematodes and arthropods. Note that this family contains a number of conserved cysteine and histidine residues.

[]

0

[ "PFAM" ]

[ "PF06869" ]

[ "DUF1258" ]

[ 799 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 799 ]

1

[ "Caenorhabditis elegans" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1258

DUF1258

9

IPR009668

9,668

RNA polymerase I associated factor, A49-like

RNA_pol-assoc_fac_A49-like

Family

4,443

false

Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures. Deletion analysis of the fusion yeast homologue indicates that o...

[ "GO:0003677", "GO:0006351" ]

[ "DNA binding", "DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06870", "PTHR14440" ]

[ "RNA_pol_I_A49", "" ]

[ 4422, 4294 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-73762", "R-DDI-73772", "R-HSA-427413", "R-HSA-5250924", "R-HSA-73762", "R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-MMU-73772", "R-MMU-73863", "R-SCE-73762", "R-SCE-73772", "R-SPO-73762", "R-SPO-73772" ]

[ "REACTOME:R-DDI-73762", "REACTOME:R-DDI-73772", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73772", "REACTOME:R-HSA-73863", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-73762", "REACTOME:R-MMU-73772", "REACTOME:R-MMU-73863", "REACTOME:R-SCE-73762", ...

15

[ "3nff", "3nfg", "3nfh", "3nfi", "4c2m", "4c3h", "4c3i", "4c3j", "4ym7", "5g5l", "5lmx", "5m3f", "5m3m", "5m5w", "5m5x", "5m5y", "5m64", "5n5y", "5n5z", "5n60", "5n61", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6h67", "6h68", "6hko", "6rqh", "6rql", "6rqt"...

50

[ "PUB00012886" ]

[ "12893961" ]

[ "The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase I and required for maximizing transcription of ribosomal DNA." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4443 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 5, 3, 1, 3, 4, 1, 1, 6 ]

12

true

Family

RNA polymerase I associated factor, A49-like

RNA_pol-assoc_fac_A49-like

8

IPR009669

9,669

Cysteine protease, VirA/EspG

Cys_protease_VirA/EspG

Family

83

false

This entry represents a family of bacterial virulence proteins, including EspG from Citrobacter rodentium and Escherichia coli and VirA from Shigella flexneri. Both EspG and VirA are delivered into infected host epithelial cells by a type III secretory system [ , ]. These proteins function through the disruption of the...

[ "GO:0004197" ]

[ "cysteine-type endopeptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF" ]

[ "PF06872", "PIRSF011515" ]

[ "EspG", "EspG" ]

[ 83, 72 ]

2

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[ "3eb8", "3ee1", "3pcr", "3pcs", "3q1c", "4fma", "4fmb", "4fmc", "4fmd", "4fme" ]

10

[ "PUB00012887", "PUB00043282", "PUB00043283", "PUB00043284", "PUB00043285" ]

[ "11349072", "18312845", "15972534", "17095701", "12065406" ]

[ "EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri.", "Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli.", "Enteropathogenic Escherichia coli type III effectors Es...

[ 2001, 2008, 2005, 2006, 2002 ]

5

[]

0

null

[ "Enterobacterales" ]

[ 83 ]

1

[]

0

true

Family

Cysteine protease, VirA/EspG

Cys_protease_VirA/EspG

8

IPR009671

9,671

Regulator of ribonuclease activity B domain

RraB_dom

Domain

5,550

false

This entry represents a domain found in regulator of ribonuclease activity B (RraB) protein. RraB regulates mRNA abundance by binding to RNaseE and inhibiting its endonucleolytic activity [ , ]. A subset of these proteins are predicted to function as immunity proteins [ ].

[]

0

[ "PFAM" ]

[ "PF06877" ]

[ "RraB" ]

[ 5550 ]

1

[]

0

[ "1nxi" ]

1

[ "PUB00035720", "PUB00056807", "PUB00066726" ]

[ "16771842", "18510556", "22731697" ]

[ "Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.", "Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA.", "Polymorphic toxin systems: Comprehensive characteriz...

[ 2006, 2008, 2012 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5521, 9, 20 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Regulator of ribonuclease activity B domain

RraB_dom

2

IPR009674

9,674

DNA-directed RNA polymerase I subunit RPA2, domain 4

Rpa2_dom_4

Domain

4,475

false

This domain is found between domain 3 and domain 5, but shows no homology to domain 4 of Rpb2. The external domains in multisubunit RNA polymerase (those most distant from the active site) are known to demonstrate more sequence variability [ ].

[ "GO:0003899", "GO:0006351", "GO:0005634" ]

[ "DNA-directed RNA polymerase activity", "DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06883" ]

[ "RNA_pol_Rpa2_4" ]

[ 4475 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.7.6", "R-CEL-5250924", "R-CEL-73762", "R-CEL-73772", "R-DDI-73762", "R-DDI-73772", "R-DME-73762", "R-DME-73772", "R-HSA-427413", "R-HSA-5250924", "R-HSA-73762", "R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-MMU-73772", "R-MMU-73863", "R-SCE-73762", "R-SCE-...

[ "EC:2.7.7.6", "REACTOME:R-CEL-5250924", "REACTOME:R-CEL-73762", "REACTOME:R-CEL-73772", "REACTOME:R-DDI-73762", "REACTOME:R-DDI-73772", "REACTOME:R-DME-73762", "REACTOME:R-DME-73772", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73772", "REACTOME...

21

[ "4c2m", "4c3h", "4c3i", "4c3j", "4ym7", "5g5l", "5lmx", "5m3f", "5m3m", "5m5w", "5m5x", "5m5y", "5m64", "5n5y", "5n5z", "5n60", "5n61", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6h67", "6h68", "6hko", "6hlq", "6hlr", "6hls", "6rqh", "6rql", "6rqt", "6rrd"...

55

[ "PUB00008731" ]

[ "11313498" ]

[ "Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 4474, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 6, 3, 1, 4, 2, 1, 1, 10 ]

12

true

Domain

DNA-directed RNA polymerase I subunit RPA2, domain 4

Rpa2_dom_4

8

IPR009675

9,675

TPX2

TPX2_fam

Family

5,896

false

This family represents the eukaryotic targeting protein for Xklp2 (TPX2). TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenan...

[ "GO:0032147", "GO:0060236", "GO:0005819", "GO:0005874" ]

[ "activation of protein kinase activity", "regulation of mitotic spindle organization", "spindle", "microtubule" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PANTHER" ]

[ "PTHR14326" ]

[ "" ]

[ 5896 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6804756", "R-HSA-8854518", "R-MMU-6804756", "R-MMU-8854518", "R-XTR-6804756", "R-XTR-8854518" ]

[ "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-6804756", "REACTOME:R-MMU-8854518", "REACTOME:R-XTR-6804756", "REACTOME:R-XTR-8854518" ]

6

[ "6bjc", "8cx6" ]

2

[ "PUB00012901", "PUB00012902", "PUB00063872" ]

[ "8548825", "10871281", "18663142" ]

[ "Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis.", "TPX2, A novel xenopus MAP involved in spindle pole organization.", "Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A." ]

[ 1996, 2000, 2008 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5896 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 44, 4, 4, 3, 15, 4, 62 ]

7

true

Family

TPX2

TPX2_fam

7

IPR009676

9,676

Protein of unknown function DUF1265

DUF1265

Family

39

false

This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be restricted to Caenorhabditis elegans.

[]

0

[ "PFAM" ]

[ "PF06887" ]

[ "DUF1265" ]

[ 39 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditomorpha" ]

[ 39 ]

1

[ "Caenorhabditis elegans" ]

[ 11 ]

1

true

Family

Protein of unknown function DUF1265

DUF1265

2

IPR009677

9,677

Protein of unknown function DUF1266

DUF1266

Domain

4,587

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06889" ]

[ "DUF1266" ]

[ 4587 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "Opisthokonta", "metagenomes", "unclassified Caudoviricetes" ]

[ 4563, 11, 4, 7, 2 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Protein of unknown function DUF1266

DUF1266

1

IPR009678

9,678

Bacteriophage tail completion protein R

Phage_tail_completion_R

Family

3,655

false

Bacteriophage tail completion R is thought to be essential for stable head joining [ ].

[]

0

[ "PFAM" ]

[ "PF06891" ]

[ "P2_Phage_GpR" ]

[ 3655 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00012904" ]

[ "8178426" ]

[ "Molecular cloning and characterization of bacteriophage P2 genes R and S involved in tail completion." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Nosema bombycis (strain CQ1 / CVCC 102059)", "Viruses", "metagenomes" ]

[ 3500, 1, 142, 12 ]

4

[]

0

true

Family

Bacteriophage tail completion protein R

Phage_tail_completion_R

5

IPR009679

9,679

Bacteriophage 186, CII-like

Phage_186_CII-like

Family

4,184

false

This entry represents Regulatory protein CII from Escherichia phage 186 (Bacteriophage 186) and similar proteins from tailed bacteriophages (Caudovirales) and prophages from Proteobacteria. CII (also known as CP76) is a transcriptional activator essential for the establishment of lysogeny [ , , ]. The expression of thi...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06892" ]

[ "Phage_CP76" ]

[ 4184 ]

1

[]

0

[ "6vli", "6vmh", "6vpe" ]

3

[ "PUB00012905", "PUB00020087", "PUB00100041", "PUB00100138" ]

[ "3806670", "2704042", "33211866", "34681220" ]

[ "Control of gene expression in the P2-related template coliphages. III. DNA sequence of the major control region of phage 186.", "Control of gene expression in the P2-related temperate coliphage 186. VI. Sequence analysis of the early lytic region.", "Instability of CII is needed for efficient switching between...

[ 1986, 1989, 2020, 2021 ]

4

[]

[ "IPR048188" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4086, 7, 75, 16 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bacteriophage 186, CII-like

Phage_186_CII-like

7

IPR009681

9,681

Phage tail assembly chaperone protein, Siphoviridae

Phage_TAC_Siphoviridae

Family

350

false

This is a family of phage tail tube assembly chaperone proteins from some Siphoviridae viruses [ ].

[]

0

[ "PFAM" ]

[ "PF06896" ]

[ "Phage_TAC_3" ]

[ 350 ]

1

[]

0

[]

0

[ "PUB00075454" ]

[ "23542344" ]

[ "A conserved spiral structure for highly diverged phage tail assembly chaperones." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Castilleja foliolosa", "Methanobrevibacter arboriphilus", "Viruses" ]

[ 246, 1, 1, 102 ]

4

[]

0

true

Family

Phage tail assembly chaperone protein, Siphoviridae

Phage_TAC_Siphoviridae

3

IPR009683

9,683

Extensin-like, C-terminal

Extensin-like_C

Domain

5,858

false

This entry represents the C terminus (approx. 120 residues) of a number of bacterial extensin-like proteins. Extensins are cell wall glycoproteins normally associated with plants, where they strengthen the cell wall in response to mechanical stress [ ].

[]

0

[ "PFAM" ]

[ "PF06904" ]

[ "Extensin-like_C" ]

[ 5858 ]

1

[]

0

[]

0

[ "PUB00012911" ]

[ "8148875" ]

[ "Extensin: repetitive motifs, functional sites, post-translational codes, and phylogeny." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Diploscapter pachys", "ecological metagenomes" ]

[ 5832, 2, 24 ]

3

[]

0

true

Domain

Extensin-like, C-terminal

Extensin-like_C

7

IPR009684

9,684

Latexin

Family

1,500

false

This family consists of several animal specific latexin and proteins related to latexin that belong to MEROPS proteinase inhibitor family I47, clan I- [ ].

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF011132", "PTHR28591" ]

[ "Prot_inh_latexin", "" ]

[ 297, 1500 ]

2

[]

0

[ "1wnh", "2bo9" ]

2

[ "PUB00012913", "PUB00014133", "PUB00014970", "PUB00014971", "PUB00014972", "PUB00014973" ]

[ "11455960", "14705960", "10698712", "12952168", "8601727", "11929948" ]

[ "Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor.", "Evolutionary families of peptidase inhibitors.", "Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures disti...

[ 2000, 2004, 2000, 2003, 1996, 2002 ]

6

[]

[ "IPR027261" ]

0

1

0

[ "Bilateria" ]

[ 1500 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 3, 4, 5 ]

4

true

Family

Latexin

9

IPR009685

9,685

Male enhanced antigen 1

MEA1

Family

1,285

false

This family consists of several mammalian male enhanced antigen 1 (MEA1) proteins. The Mea-1 gene is found to be localised in primary and secondary spermatocytes and spermatids, but the protein products are detected only in spermatids. Intensive transcription of Mea-1 gene and specific localisation of the gene product ...

[ "GO:0007283" ]

[ "spermatogenesis" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR17005" ]

[ "" ]

[ 1285 ]

1

[]

0

[]

0

[ "PUB00012914" ]

[ "8907304" ]

[ "Genomic sequence analysis of the bovine male-enhanced antigen-1 (Mea-1) and differential localization of its transcripts and products during spermatogenesis." ]

[ 1996 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1285 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 3, 6, 5 ]

5

true

Family

Male enhanced antigen 1

MEA1

9

IPR009686

9,686

Senescence/spartin-associated, C-terminal

Senescence/spartin_C

Domain

6,129

false

This is the AAA ATPase domain found at the C-terminal of plant senescence-associated proteins and spartin. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours, after the flower opens, and it is believed that senescence proteins produced around that tim...

[]

0

[ "PFAM" ]

[ "PF06911" ]

[ "Senescence" ]

[ 6129 ]

1

[]

0

[]

0

[ "PUB00012915", "PUB00050561", "PUB00053590", "PUB00097767" ]

[ "10412903", "18202664", "12676568", "23439121" ]

[ "Identification of senescence-associated genes from daylily petals.", "Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.", "The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia.", "Spartin regulates synaptic...

[ 1999, 2008, 2003, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 10, 6119 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 35, 1, 2, 2, 5, 3, 1, 10, 5, 17 ]

10

true

Domain

Senescence/spartin-associated, C-terminal

Senescence/spartin_C

5

IPR009689

9,689

Protein of unknown function DUF1280

DUF1280

Family

698

false

This family represents a conserved region approximately 200 residues long within a number of proteins of unknown function that seem to be specific to Caenorhabditis elegans.

[]

0

[ "PFAM" ]

[ "PF06918" ]

[ "DUF1280" ]

[ 698 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 698 ]

1

[ "Caenorhabditis elegans" ]

[ 5 ]

1

true

Family

Protein of unknown function DUF1280

DUF1280

1

IPR009690

9,690

Bacteriophage T4, Gp30.7

Phage_T4_Gp30_7

Family

256

false

This family consists of several phage Gp30.7 proteins of 121 residues in length. Family members seem to be exclusively from the T4-like viruses. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06919" ]

[ "Phage_T4_Gp30_7" ]

[ 256 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Salmonella enterica", "Viruses" ]

[ 22, 234 ]

2

[]

0

true

Family

Bacteriophage T4, Gp30.7

Phage_T4_Gp30_7

6

IPR009692

9,692

P13 protein, Citrus tristeza virus

P13_Citrus_tristeza_virus

Family

90

false

This entry represents the 13kDa P13 protein from Citrus tristeza virus (CTV) strains. CTV, a member of the closterovirus group, is one of the more complex single-stranded RNA viruses [ ]. The function of the P13 protein is unknown.

[]

0

[ "PFAM" ]

[ "PF06922" ]

[ "CTV_P13" ]

[ 90 ]

1

[]

0

[]

0

[ "PUB00012918" ]

[ "9024813" ]

[ "Kinetics of accumulation of citrus tristeza virus RNAs." ]

[ 1997 ]

1

[]

0

null

[ "Citrus tristeza virus" ]

[ 90 ]

1

[]

0

true

Family

P13 protein, Citrus tristeza virus

P13_Citrus_tristeza_virus

2

IPR009693

9,693

Glucitol operon activator

Glucitol_operon_activator

Family

2,198

false

This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system, which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF007592", "PF06923", "PIRSF011474" ]

[ "PRK10234.1", "GutM", "Glucitol_operon_activator" ]

[ 821, 2198, 1337 ]

3

[]

0

[]

0

[ "PUB00012919" ]

[ "3062173" ]

[ "Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli." ]

[ 1988 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2184, 14 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glucitol operon activator

Glucitol_operon_activator

6

IPR009694

9,694

Domain of unknown function DUF1281

DUF1281

Domain

1,183

false

This entry describes a domain of unkown function found generally at the N-terminal of YubA and YubB in enterobacteriaceae. This domain is mostly found in Escherichia coli, Salmonella typhimurium and Shigella species. This domain is usually found in association with . YubA and YubB have not been fully functionally chara...

[]

0

[ "PFAM" ]

[ "PF06924" ]

[ "DUF1281" ]

[ 1183 ]

1

[]

0

[ "2ijr" ]

1

[ "PUB00160281" ]

[ "28248504" ]

[ "Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci." ]

[ 2017 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 1183 ]

1

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF1281

DUF1281

5

IPR009695

9,695

Diacylglycerol glucosyltransferase, N-terminal

Diacylglyc_glucosyltr_N

Domain

7,717

false

This entry represents a conserved region of approximately 180 residues found towards the N terminus of a number of glycosyltransferases, such as plant chloroplastic monogalactosyldiacylglycerol synthases [ ] and bacterial diacylglycerol glucosyltransferases [ ].

[ "GO:0016758", "GO:0009247" ]

[ "hexosyltransferase activity", "glycolipid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06925" ]

[ "MGDG_synth" ]

[ 7717 ]

1

[ "EC", "GP", "METACYC" ]

[ "2.4.1.315", "GenProp1302", "PWY-7817" ]

[ "EC:2.4.1.315", "GP:GenProp1302", "METACYC:PWY-7817" ]

3

[ "4wyi", "4x1t" ]

2

[ "PUB00012920", "PUB00070820" ]

[ "11553816", "17209021" ]

[ "Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana.", "Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus." ]

[ 2001, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina mazei", "metagenomes" ]

[ 5669, 2005, 1, 42 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 9, 10 ]

3

true

Domain

Diacylglycerol glucosyltransferase, N-terminal

Diacylglyc_glucosyltr_N

2

IPR009696

9,696

Putative replisome organiser, C-terminal

Rep_Org_C

Domain

60

false

This entry represents the C terminus (approximately 100 residues) of a putative replisome organiser protein in Lactococcus bacteriophages [ ].

[]

0

[ "PFAM" ]

[ "PF06926" ]

[ "Rep_Org_C" ]

[ 60 ]

1

[]

0

[]

0

[ "PUB00012921" ]

[ "11157223" ]

[ "Improvement and optimization of two engineered phage resistance mechanisms in Lactococcus lactis." ]

[ 2001 ]

1

[]

0

null

[ "Caudoviricetes", "Lactobacillales", "Zophobas morio" ]

[ 3, 56, 1 ]

3

[]

0

true

Domain

Putative replisome organiser, C-terminal

Rep_Org_C

9

IPR009699

9,699

Mastadenovirus E4/Orf3

Mastadenovirus_E4/Orf3

Family

194

false

This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is th...

[]

0

[ "PFAM" ]

[ "PF06931" ]

[ "Adeno_E4_ORF3" ]

[ 194 ]

1

[]

0

[ "4djb" ]

1

[ "PUB00012925" ]

[ "12692231" ]

[ "Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation." ]

[ 2003 ]

1

[]

0

null

[ "Mastadenovirus" ]

[ 194 ]

1

[]

0

true

Family

Mastadenovirus E4/Orf3

Mastadenovirus_E4/Orf3

9

IPR009701

9,701

Special lobe-specific silk SSP160

SSP160

Family

15

false

This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomidae species.

[]

0

[ "PFAM" ]

[ "PF06933" ]

[ "SSP160" ]

[ 15 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chironomidae" ]

[ 15 ]

1

[]

0

true

Family

Special lobe-specific silk SSP160

SSP160

6

IPR009702

9,702

Protein of unknown function DUF1284

DUF1284

Family

1,482

false

This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.

[]

0

[ "PFAM" ]

[ "PF06935" ]

[ "DUF1284" ]

[ 1482 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Arthropoda", "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 4, 1360, 109, 9 ]

4

[]

0

true

Family

Protein of unknown function DUF1284

DUF1284

4

IPR009703

9,703

Selenoprotein S

Selenoprotein_S

Family

1,293

false

This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. These proteins are involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins which participate in the transfer of misfol...

[ "GO:0006886", "GO:0005789" ]

[ "intracellular protein transport", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06936", "PTHR28621" ]

[ "Selenoprotein_S", "" ]

[ 1281, 1211 ]

2

[ "REACTOME" ]

[ "R-HSA-8866654" ]

[ "REACTOME:R-HSA-8866654" ]

1

[ "2q2f", "5kiu", "5kiw", "5kiy" ]

4

[ "PUB00015116" ]

[ "12477932" ]

[ "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1293 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 3, 6 ]

5

true

Family

Selenoprotein S

Selenoprotein_S

3

IPR009704

9,704

EURL protein

EURL_prot

Family

1,075

false

This family consists of several animal EURL proteins. EURL is preferentially expressed in chick retinal precursor cells as well as in the anterior epithelial cells of the lens at early stages of development. EURL transcripts are found primarily in the peripheral dorsal retina, i.e., the most undifferentiated part of th...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06937", "PTHR15961" ]

[ "EURL", "" ]

[ 1063, 1038 ]

2

[]

0

[]

0

[ "PUB00012937" ]

[ "12815627" ]

[ "Isolation of a novel cDNA enriched in the undifferentiated chick retina and lens." ]

[ 2003 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1075 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 5, 3 ]

4

true

Family

EURL protein

EURL_prot

8

IPR009705

9,705

Protein of unknown function DUF1286

DUF1286

Family

124

false

This family consists of several hypothetical archaeal proteins of around 120 residues in length. Most proteins in this group are found in the family Sulfolobaceae. The function of this protein family is unknown.

[]

0

[ "PFAM" ]

[ "PF06939" ]

[ "DUF1286" ]

[ 124 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 124 ]

1

[]

0

true

Family

Protein of unknown function DUF1286

DUF1286

3

IPR009706

9,706

Protein of unknown function DUF1287

DUF1287

Family

2,278

false

This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06940", "PIRSF011444" ]

[ "DUF1287", "DUF1287" ]

[ 2278, 1518 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2230, 5, 43 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1287

DUF1287

7

IPR009707

9,707

Membrane protein GlpM/YdgC

GlpM/YdgC

Family

1,848

false

This family consists of several bacterial membrane proteins, including GlpM Pseudomonas aeruginosa and YdgC from E. coli . GlpM may play a role in alginate biosynthesis [ ]. The function of inner membrane protein YdgC is not clear [ ].

[]

0

[ "PFAM" ]

[ "PF06942" ]

[ "GlpM" ]

[ 1848 ]

1

[]

0

[]

0

[ "PUB00012939", "PUB00042652" ]

[ "7642508", "15919996" ]

[ "Identification of Pseudomonas aeruginosa glpM, whose gene product is required for efficient alginate biosynthesis from various carbon sources.", "Global topology analysis of the Escherichia coli inner membrane proteome." ]

[ 1995, 2005 ]

2

[]

0

null

[ "Bacteria", "Steinernema glaseri", "metagenomes" ]

[ 1842, 1, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Membrane protein GlpM/YdgC

GlpM/YdgC

7

IPR009708

9,708

Bacteriophage A118-like, holin/antiholin

Phage_A118_holin/antiholin

Family

498

false

This entry represents the Bacteriophage A118-like, holin/antiholin protein. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. An alternative isoform exists that is thought to function as an antiholin by counteracting the aggregation of the holin molecules. The is...

[]

0

[ "PFAM" ]

[ "PF06946" ]

[ "Phage_holin_5_1" ]

[ 498 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00010120", "PUB00092874", "PUB00105459" ]

[ "11459934", "2138979", "25157079" ]

[ "Holins kill without warning.", "The lethal lambda S gene encodes its own inhibitor.", "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications." ]

[ 2001, 1990, 2015 ]

3

[]

0

null

[ "Bacteria", "Viruses", "bioreactor metagenome" ]

[ 485, 12, 1 ]

3

[]

0

true

Family

Bacteriophage A118-like, holin/antiholin

Phage_A118_holin/antiholin

6

IPR009709

9,709

Protein of unknown function DUF1290

DUF1290

Family

3,811

false

This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06947", "PIRSF018579" ]

[ "DUF1290", "Sbp" ]

[ 3811, 3700 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3776, 35 ]

2

[]

0

true

Family

Protein of unknown function DUF1290

DUF1290

4

IPR009711

9,711

Uncharacterised protein family UPF0473

UPF0473

Family

7,542

false

This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01448", "PF06949", "PTHR40066" ]

[ "UPF0473", "DUF1292", "" ]

[ 3509, 7535, 3158 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctLx49", "metagenomes" ]

[ 11, 7469, 8, 1, 53 ]

5

[]

0

true

Family

Uncharacterised protein family UPF0473

UPF0473

8

IPR009712

9,712

Vibrio phage Vf33, Vpf117

Vibrio_phage_Vf33_Vpf117

Family

102

false

This entry is represented by Vibrio phage Vf33, Vpf117. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06950" ]

[ "DUF1293" ]

[ 102 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Inoviridae" ]

[ 82, 20 ]

2

[]

0

true

Family

Vibrio phage Vf33, Vpf117

Vibrio_phage_Vf33_Vpf117

1

IPR009713

9,713

Uncharacterised protein family PsiA

Uncharacterised_PsiA

Family

1,335

false

This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli [ ].

[]

0

[ "PFAM" ]

[ "PF06952" ]

[ "PsiA" ]

[ 1335 ]

1

[]

0

[]

0

[ "PUB00012941" ]

[ "3526338" ]

[ "An inhibitor of SOS induction, specified by a plasmid locus in Escherichia coli." ]

[ 1986 ]

1

[]

0

null

[ "Bacteria", "Protostomia", "metagenomes" ]

[ 1329, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family PsiA

Uncharacterised_PsiA

1

IPR009714

9,714

Resistin-like molecule hormone family

RELM

Family

569

false

RELMs, secreted proteins with roles including insulin resistance and the activation of inflammatory processes, are also known as found in inflammatory zone (FIZZ), and include four members in mouse (RELM-alpha/FIZZ1/HIMF, RELM-beta/FIZZ2, Resistin/FIZZ3, and RELM-gamma/FIZZ4) and two members in human (resistin and RELM...

[ "GO:0005179", "GO:0005576" ]

[ "hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06954", "PTHR21101", "cd16333" ]

[ "Resistin", "", "RELM" ]

[ 560, 544, 398 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-HSA-6798695", "R-HSA-9615017", "R-MMU-6798695" ]

[ "REACTOME:R-BTA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9615017", "REACTOME:R-MMU-6798695" ]

4

[ "1rfx", "1rgx", "1rh7" ]

3

[ "PUB00030653", "PUB00094721", "PUB00094724", "PUB00094725", "PUB00094726", "PUB00094727", "PUB00094728", "PUB00094729", "PUB00094730", "PUB00094731" ]

[ "15155948", "24320036", "26662574", "18975914", "12594039", "27001185", "11201732", "28192887", "28417458", "29866514" ]

[ "Disulfide-dependent multimeric assembly of resistin family hormones.", "Resistin: an inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome.", "Resistin's, obesity and insulin resistance: the continuing disconnect between rodents and humans.", "Biophysical analyses of hum...

[ 2004, 2014, 2016, 2008, 2003, 2016, 2001, 2017, 2017, 2018 ]

10

[]

0

null

[ "Eumetazoa", "Teichococcus vastitatis" ]

[ 568, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 11, 10 ]

3

true

Family

Resistin-like molecule hormone family

RELM

5

IPR009715

9,715

Regulator of RNA terminal phosphate cyclase

RtcR

Domain

2,098

false

RtcR is a sigma54-dependent enhancer binding protein [ ] that activates transcription of the rtcBA operon. The product of the rtcA gene is an RNA 3 -terminal phosphate cyclase [ ]. This domain is found at the N terminus of the RtcR sequence. RtcR, and other sigma54-dependent activators, contain in the central region of...

[]

0

[ "PFAM" ]

[ "PF06956" ]

[ "RtcR" ]

[ 2098 ]

1

[]

0

[]

0

[ "PUB00012944", "PUB00012945" ]

[ "12618438", "9738023" ]

[ "Domain architectures of sigma54-dependent transcriptional activators.", "Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon." ]

[ 2003, 1998 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2090, 3, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Regulator of RNA terminal phosphate cyclase

RtcR

1

IPR009716

9,716

Ferroportin-1

Family

5,772

false

This entry represents the Solute carrier family 40 member 1 (SLC40A) family of proteins, also known as Ferroportin 1 (or simply ferroportin (FPN), the major iron transporter key in cellular and systemic iron levels balance. In mammals, it mediates the absorption of dietary iron by transporting ferrous iron across the b...

[ "GO:0005381", "GO:0034755", "GO:0016020" ]

[ "iron ion transmembrane transporter activity", "iron ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06963", "PTHR11660", "cd17480" ]

[ "FPN1", "", "MFS_SLC40A1_like" ]

[ 5765, 5655, 3369 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-425410", "R-CFA-917937", "R-DRE-425410", "R-DRE-917937", "R-HSA-425410", "R-HSA-5619049", "R-HSA-5619060", "R-HSA-5655799", "R-HSA-917937", "R-MMU-425410", "R-MMU-917937", "R-RNO-425410", "R-RNO-917937" ]

[ "REACTOME:R-CFA-425410", "REACTOME:R-CFA-917937", "REACTOME:R-DRE-425410", "REACTOME:R-DRE-917937", "REACTOME:R-HSA-425410", "REACTOME:R-HSA-5619049", "REACTOME:R-HSA-5619060", "REACTOME:R-HSA-5655799", "REACTOME:R-HSA-917937", "REACTOME:R-MMU-425410", "REACTOME:R-MMU-917937", "REACTOME:R-RNO-...

13

[ "5aym", "5ayn", "5ayo", "6btx", "6vyh", "6w4s", "6wbv", "6wik", "8bzy", "8c02", "8c03", "8dl6", "8dl7", "8dl8" ]

14

[ "PUB00054047", "PUB00099591", "PUB00099592", "PUB00099593" ]

[ "10882071", "29237594", "32814342", "30082682" ]

[ "A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.", "Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin.", "Structure of hepcidin-bound ferroportin reveals iron homeostatic m...

[ 2000, 2018, 2020, 2018 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "seawater metagenome" ]

[ 11, 5760, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 2, 19, 10, 3, 1, 8, 4, 36 ]

9

true

Family

Ferroportin-1

5