LiteFold/InterPro · Datasets at Hugging Face

IPR010209

10,209

Ion-translocating oxidoreductase complex, subunit RnfG/RsxG

Ion_transpt_RnfG/RsxG

Family

7,929

false

The six-subunit complex RnfABCDGE in Rhodobacter capsulatus (Rhodopseudomonas capsulata) encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation [ ]. A closely related complex in Escherichia coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containi...

[ "GO:0009055", "GO:0022900", "GO:0005886" ]

[ "electron transfer activity", "electron transport chain", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00479", "PIRSF006091", "PTHR36118", "TIGR01947" ]

[ "RsxG_RnfG", "E_trnsport_RnfG", "", "rnfG" ]

[ 6533, 6335, 7887, 6138 ]

4

[ "GP" ]

[ "GenProp0130" ]

[ "GP:GenProp0130" ]

1

[ "3dcz", "7zc6", "8ahx", "8rb8", "8rb9", "8rbm", "8rbq", "9eri", "9erj", "9erk", "9erl" ]

11

[ "PUB00008135", "PUB00013513" ]

[ "9492268", "12773378" ]

[ "Overexpression in Escherichia coli of the rnf genes from Rhodobacter capsulatus--characterization of two membrane-bound iron-sulfur proteins.", "A reducing system of the superoxide sensor SoxR in Escherichia coli." ]

[ 1998, 2003 ]

2

[]

[ "IPR049687" ]

0

1

0

[ "Bacteria", "Methanobacteriota", "Opisthokonta", "unclassified sequences" ]

[ 7686, 41, 3, 199 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ion-translocating oxidoreductase complex, subunit RnfG/RsxG

Ion_transpt_RnfG/RsxG

1

IPR010210

10,210

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase

ADH_synthase

Family

1,066

false

This entry represents a family of enzymes related to fructose-bisphosphate aldolase. This enzyme catalyses a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic...

[ "GO:0016836", "GO:0009073" ]

[ "hydro-lyase activity", "aromatic amino acid family biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00960", "TIGR01949" ]

[ "ADH_synthase", "ADH_synth" ]

[ 990, 1061 ]

2

[ "EC", "GP", "METACYC" ]

[ "2.2.1.10", "GenProp0001", "PWY-6160" ]

[ "EC:2.2.1.10", "GP:GenProp0001", "METACYC:PWY-6160" ]

3

[ "2qjg", "2qjh", "2qji" ]

3

[ "PUB00060486", "PUB00060487" ]

[ "15182204", "18318840" ]

[ "L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.", "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity." ]

[ 2004, 2008 ]

2

[ "IPR041720" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 800, 244, 22 ]

3

[]

0

true

Family

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase

ADH_synthase

4

IPR010211

10,211

Redox-sensitive transcriptional activator SoxR

Redox-sen_tscrpt-act_SoxR

Family

7,703

false

SoxR is a MerR-family homodimeric transcription factor with a 2Fe-2S cluster in each monomer. The motif CIGCGCxxxxxC is conserved. Oxidation of the iron-sulphur cluster activates SoxR. The physiological role in Escherichia coli is response to oxidative stress. It is activated by superoxide, singlet oxygen, nitric oxide...

[ "GO:0003677", "GO:0051537", "GO:0006355", "GO:0006979" ]

[ "DNA binding", "2 iron, 2 sulfur cluster binding", "regulation of DNA-templated transcription", "response to oxidative stress" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "NCBIFAM", "CDD" ]

[ "TIGR01950", "cd01110" ]

[ "SoxR", "HTH_SoxR" ]

[ 7702, 6517 ]

2

[]

0

[ "2zhg", "2zhh" ]

2

[ "PUB00067988" ]

[ "12670967" ]

[ "Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization." ]

[ 2003 ]

1

[ "IPR047057" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 7656, 4, 43 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Redox-sensitive transcriptional activator SoxR

Redox-sen_tscrpt-act_SoxR

3

IPR010212

10,212

Probable transcription termination protein NusA, archaeal

NusA_arc

Family

936

false

This entry represents a family of archaeal proteins found in a single copy per genome. It contains two KH domains and is most closely related to the central region bacterial NusA, a transcription termination factor named for its interaction with phage lambda protein N in Escherichia coli. The proteins required for anti...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00945_A", "TIGR01952" ]

[ "NusA_A", "nusA_arch" ]

[ 902, 935 ]

2

[]

0

[ "2cxc", "2cy1" ]

2

[]

0

[ "IPR030842" ]

[]

1

0

1

[ "Archaea", "Candidatus Rhodobacter oscarellae", "Geodia barretti", "ecological metagenomes" ]

[ 901, 1, 1, 33 ]

4

[]

0

true

Family

Probable transcription termination protein NusA, archaeal

NusA_arc

6

IPR010213

10,213

Transcription factor NusA

TF_NusA

Domain

24,865

false

This entry describes NusA. This entry represents a region of NusA shared by all bacterial forms, and includes the S1 ( ) and KH RNA binding domains. Proteobacterial forms have an additional C-terminal region, not included in this entry, with two repeats of 50-residue domain rich in acidic amino acids. NusA is involved ...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01953" ]

[ "NusA" ]

[ 24865 ]

1

[ "GP" ]

[ "GenProp0132" ]

[ "GP:GenProp0132" ]

1

[ "1hh2", "1k0r", "1l2f", "2asb", "2atw", "4mtn", "5lm7", "5lm9", "5ms0", "6flq", "6gov", "6j9e", "6tqn", "6tqo", "6x6t", "6x7f", "6x7k", "6x9q", "6xas", "6xav", "6xdq", "6z9p", "6z9q", "6z9r", "6z9s", "6z9t", "7adb", "7adc", "7add", "7ade", "7py3", "7py5"...

63

[ "PUB00013514", "PUB00026894" ]

[ "11040219", "14621988" ]

[ "The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA.", "Crystal structure of NusA from Thermotoga maritima and functional implication of the N-terminal domain." ]

[ 2000, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24324, 64, 477 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcription factor NusA

TF_NusA

3

IPR010214

10,214

Transcription termination factor NusA, C-terminal duplication

Tscrpt_termin_fac_NusA_C_rpt

Repeat

8,873

false

NusA, or N utilisation substance protein A, is a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. It is named for the interaction in Escherichia coli of Bacteriophage lambda antitermination protein N with the N-utilisation s...

[]

0

[ "NCBIFAM" ]

[ "TIGR01954" ]

[ "nusA_Cterm_rpt" ]

[ 8873 ]

1

[ "GP" ]

[ "GenProp0132" ]

[ "GP:GenProp0132" ]

1

[ "1u9l", "1wcl", "1wcn", "2jzb", "5lm7", "5lm9", "5ms0", "6flq", "6gov", "6ib8", "6j9e", "6tqn", "6tqo", "6x6t", "6x7f", "6x7k", "6x9q", "6xas", "6xav", "6xdq", "6z9p", "6z9q", "6z9r", "6z9s", "6z9t", "7adb", "7adc", "7add", "7ade", "7py3", "7py5", "7py6"...

62

[ "PUB00013514" ]

[ "11040219" ]

[ "The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8721, 43, 109 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Repeat

Transcription termination factor NusA, C-terminal duplication

Tscrpt_termin_fac_NusA_C_rpt

3

IPR010215

10,215

Transcription antitermination protein RfaH

Transcription_antiterm_RfaH

Family

2,549

false

This entry represents the transcription antitermination protein, RfaH [ ]. This protein is most closely related to the transcriptional termination/antitermination protein NusG ( ) and contains the KOW motif ( ) [ ]. This protein appears to be limited to the proteobacteria. In Escherichia coli, it enhances distal genes ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00951", "TIGR01955" ]

[ "RfaH", "RfaH" ]

[ 2017, 2548 ]

2

[]

0

[ "2oug", "5ond", "6c6s", "6c6t", "8pen", "8pfg", "8pfj", "8phk", "8pib", "8pid", "8pil", "8pim", "8upo", "8upr", "8uql", "8uqm", "8uqp", "8ur0", "8urh", "8uri", "8urx", "8ury", "8vkv", "8vl1", "8voo" ]

25

[ "PUB00005458", "PUB00013807", "PUB00068165", "PUB00068166", "PUB00068167", "PUB00068168" ]

[ "8987397", "1584020", "8606157", "12007406", "11983161", "16452414" ]

[ "KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins.", "Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes.", "RfaH enhances elon...

[ 1996, 1992, 1996, 2002, 2002, 2006 ]

6

[ "IPR043425" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2524, 2, 23 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription antitermination protein RfaH

Transcription_antiterm_RfaH

4

IPR010216

10,216

Transcription antitermination protein, NusG, mycoplasma-related

Transcrpt_antiterm_NusG_myco

Family

837

false

This entry represents a family proteins orthologous to the bacterial transcription termination/antitermination factor NusG from Mycoplasmas and related species. These sequences from Mycoplasma are notably diverged from those in bacterial species, and although NusA and ribosomal protein S10 (NusE) appear to be present, ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01956" ]

[ "NusG_myco" ]

[ 837 ]

1

[ "GP" ]

[ "GenProp0132" ]

[ "GP:GenProp0132" ]

1

[]

0

[]

0

[ "IPR001062" ]

[]

1

0

1

[ "Bacillati", "bioreactor metagenome" ]

[ 836, 1 ]

2

[]

0

true

Family

Transcription antitermination protein, NusG, mycoplasma-related

Transcrpt_antiterm_NusG_myco

2

IPR010217

10,217

NAD(P)H-quinone oxidoreductase subunit 5, organellar chromatophore 2

NU5C2

Family

659

false

This family represents NAD(P)H-quinone oxidoreductase subunit 5, organellar chromatophore 2 (NU5C2 or NdhF2). Proteins in this entry are mainly found in Cyanobacteria. These enzymes are responsible for the following reaction: plastoquinone + H + + NADPH = plastoquinol + H + + NADP+ It is restricted to two paralogs in e...

[]

0

[ "NCBIFAM" ]

[ "TIGR01960" ]

[ "ndhF3_CO2" ]

[ 659 ]

1

[]

0

[ "6tjv" ]

1

[ "PUB00013515", "PUB00099652" ]

[ "10383770", "26286985" ]

[ "The involvement of NAD(P)H dehydrogenase subunits, NdhD3 and NdhF3, in high-affinity CO2 uptake in Synechococcus sp. PCC7002 gives evidence for multiple NDH-1 complexes with specific roles in cyanobacteria.", "Why chloroplasts and mitochondria retain their own genomes and genetic systems: Colocation for redox re...

[ 1999, 2015 ]

2

[ "IPR003945" ]

[]

1

0

1

[ "Cyanobacteriota", "Paulinella" ]

[ 655, 4 ]

2

[]

0

true

Family

NAD(P)H-quinone oxidoreductase subunit 5, organellar chromatophore 2

NU5C2

9

IPR010218

10,218

NADH dehydrogenase, subunit C

NADH_DH_suC

Family

32,069

false

This entry describes the C subunit of the NADH dehydrogenase complex I in bacteria, as well as many instances of the corresponding mitochondrial subunit (NADH dehydrogenase subunit 9) and of the F420H2 dehydrogenase in Methanosarcina. Complex I contains subunits designated A-N. This C subunit often occurs as a fusion p...

[ "GO:0016651" ]

[ "oxidoreductase activity, acting on NAD(P)H" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01357", "TIGR01961" ]

[ "NDH1_NuoC", "NuoC_fam" ]

[ 30109, 17924 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1.-", "GenProp0135", "GenProp1230", "GenProp1254", "GenProp1341", "GenProp1537", "GenProp1583", "GenProp1608", "GenProp1637", "GenProp1751", "R-DDI-6799198", "R-DDI-9013408", "R-DME-611105", "R-DME-6799198", "R-DME-9013408", "R-DME-9837999", "R-HSA-611105", "R-HSA-6799198", ...

[ "EC:7.1.1.-", "GP:GenProp0135", "GP:GenProp1230", "GP:GenProp1254", "GP:GenProp1341", "GP:GenProp1537", "GP:GenProp1583", "GP:GenProp1608", "GP:GenProp1637", "GP:GenProp1751", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9013408", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME...

24

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6hum", "6i0d", "6i1p", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx", "6nby", "6q8o"...

323

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 117, 15134, 16434, 384 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 1, 1, 3, 1, 1, 7, 5, 3 ]

11

true

Family

NADH dehydrogenase, subunit C

NADH_DH_suC

8

IPR010221

10,221

VCBS domain

VCBS_dom

Domain

9,225

false

This domain of about 100 residues is found multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution...

[]

0

[ "NCBIFAM" ]

[ "TIGR01965" ]

[ "VCBS_repeat" ]

[ 9225 ]

1

[]

0

[ "5k8g", "6x5v", "6x5w", "6x6m", "6x6q", "6xi1", "8yke" ]

7

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]

[ 14, 8971, 161, 77, 2 ]

5

[ "Mus musculus" ]

[ 3 ]

1

true

Domain

VCBS domain

VCBS_dom

8

IPR010222

10,222

RNA helicase HrpA

RNA_helicase_HrpA

Family

11,790

false

This entry represents HrpA, one of two related but uncharacterised DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterised, is about 800 amino acids long. Related characterised eukarotic proteins ...

[ "GO:0003724" ]

[ "RNA helicase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01967" ]

[ "DEAH_box_HrpA" ]

[ 11790 ]

1

[]

0

[ "6zww", "6zwx", "7akp", "8po6", "8po7", "8po8", "9gft", "9ggr" ]

8

[ "PUB00074061", "PUB00074062" ]

[ "15186427", "24367266" ]

[ "HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli.", "HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete." ]

[ 2004, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 11711, 8, 71 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA helicase HrpA

RNA_helicase_HrpA

4

IPR010223

10,223

ATP binding protein MinD

MinD

Family

11,283

false

This entry describes MinD, a multifunctional cell division protein that guides correct placement of the septum. In Escherichia coli, the cell division site is determined by the cooperative activity of min operon products MinC, MinD, and MinE [ ]. MinD is a membrane-associated ATPase and is a septum site-determining fac...

[ "GO:0016887" ]

[ "ATP hydrolysis activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01968" ]

[ "minD_bact" ]

[ 11283 ]

1

[ "GP" ]

[ "GenProp0165" ]

[ "GP:GenProp0165" ]

1

[ "3q9l", "3r9i", "3r9j", "4v02", "4v03", "6riq" ]

6

[ "PUB00014907", "PUB00014908" ]

[ "11566131", "15126639" ]

[ "The three-dimensional structure of septum site-determining protein MinD from Pyrococcus horikoshii OT3 in complex with Mg-ADP.", "Chloroplast division site placement requires dimerization of the ARC11/AtMinD1 protein in Arabidopsis." ]

[ 2001, 2004 ]

2

[ "IPR025501" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10430, 785, 68 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 3, 2 ]

4

true

Family

ATP binding protein MinD

MinD

3

IPR010224

10,224

ATP binding protein MinD, archaea

MinD_archaea

Family

484

false

This entry represents the archaeal MinD family. The exact roles of the various archaeal MinD homologues are unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR01969" ]

[ "minD_arch" ]

[ 484 ]

1

[]

0

[ "1g3q", "1g3r", "1hyq", "1ion" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 462, 18, 4 ]

3

[]

0

true

Family

ATP binding protein MinD, archaea

MinD_archaea

8

IPR010225

10,225

ATP-dependent helicase HrpB

HrpB

Family

11,146

false

This entry represents HrpB, one of two related predicted DEAH-box ATP-dependent helicases of unknown function found in many proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti (Sinorhizobium meliloti), designated HelO, has been studied but is not essential for growth and muta...

[ "GO:0004386" ]

[ "helicase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF005496", "TIGR01970" ]

[ "ATP_hel_hrpB", "DEAH_box_HrpB" ]

[ 10696, 10861 ]

2

[]

0

[ "6eud", "6heg", "6zww", "7akp" ]

4

[ "PUB00033619", "PUB00033866" ]

[ "11839499", "9252571" ]

[ "Helicase structure and mechanism.", "A helicase gene (helO) in Rhizobium meliloti WSM419." ]

[ 2002, 1997 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11048, 40, 58 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ATP-dependent helicase HrpB

HrpB

4

IPR010226

10,226

NADH-quinone oxidoreductase, chain I

NADH_quinone_OxRdtase_chainI

Family

38,683

false

This entry represents the I subunit (one of 14 subunits, A to N) of the NADH-quinone oxidoreductase complex I ( ) which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This family does no...

[ "GO:0016651", "GO:0051539", "GO:0016020" ]

[ "oxidoreductase activity, acting on NAD(P)H", "4 iron, 4 sulfur cluster binding", "membrane" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01351", "PTHR10849", "TIGR01971" ]

[ "NDH1_NuoI", "", "NuoI" ]

[ 32095, 25347, 31709 ]

3

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1.-", "GenProp0135", "GenProp1198", "GenProp1230", "GenProp1254", "GenProp1341", "GenProp1537", "GenProp1583", "GenProp1608", "GenProp1637", "GenProp1751", "R-BTA-611105", "R-BTA-6799198", "R-CEL-6799198", "R-DME-611105", "R-DME-6799198", "R-HSA-611105", "R-HSA-6799198", "R-...

[ "EC:7.1.1.-", "GP:GenProp0135", "GP:GenProp1198", "GP:GenProp1230", "GP:GenProp1254", "GP:GenProp1341", "GP:GenProp1537", "GP:GenProp1583", "GP:GenProp1608", "GP:GenProp1637", "GP:GenProp1751", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-CEL-6799198", "REACTOME:R-DME-6...

20

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "4wz7", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6cfw", "6g2j", "6g72", "6gcs", "6h8k", "6hum", "6i0d", "6i1p", "6khi", "6khj", "6l7o", "6l7p", "6nbq"...

336

[]

0

[]

[ "IPR004497" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 972, 19506, 17592, 3, 610 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 1, 2, 1, 3, 9, 5, 1, 6, 4, 15 ]

11

true

Family

NADH-quinone oxidoreductase, chain I

NADH_quinone_OxRdtase_chainI

7

IPR010227

10,227

NADH-quinone oxidoreductase, chain M/4

NADH_Q_OxRdtase_chainM/4

Family

54,563

false

This entry contains members of the complex I subunit 4 family. Members of this family include the 13th structural gene, M, of bacterial NADH dehydrogenase I (based on Escherichia coli), as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex.

[ "GO:0008137", "GO:0042773" ]

[ "NADH dehydrogenase (ubiquinone) activity", "ATP synthesis coupled electron transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01972" ]

[ "NDH_I_M" ]

[ 54563 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "7.1.1.-", "GenProp0135", "GenProp1198", "GenProp1254", "GenProp1341", "GenProp1537", "GenProp1583", "GenProp1608", "GenProp1751", "R-BTA-5419276", "R-BTA-611105", "R-BTA-6799198", "R-DRE-611105", "R-GGA-5419276", "R-GGA-611105", "R-GGA-6799198", "R-HSA-5419276", "R-HSA-611105", ...

[ "EC:7.1.1.-", "GP:GenProp0135", "GP:GenProp1198", "GP:GenProp1254", "GP:GenProp1341", "GP:GenProp1537", "GP:GenProp1583", "GP:GenProp1608", "GP:GenProp1751", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-DRE-611105", "REACTOME:R-GGA-5419276", "R...

28

[ "3rko", "4he8", "4hea", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6hum", "6i0d", "6i1p", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx", "6nby", "6q8o", "6q8w", "6q8x", "6q9b", "6qa9"...

296

[ "PUB00005074", "PUB00043561", "PUB00045437" ]

[ "1470679", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)." ]

[ 1992, 2000, 2008 ]

3

[ "IPR003918" ]

[ "IPR022997" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 577, 21032, 32402, 552 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 1, 651, 10, 1, 5, 10, 3 ]

9

true

Family

NADH-quinone oxidoreductase, chain M/4

NADH_Q_OxRdtase_chainM/4

7

IPR010228

10,228

NADH:ubiquinone oxidoreductase, subunit G

NADH_UbQ_OxRdtase_Gsu

Family

16,918

false

This entry describes the G subunit (one of 14 subunits, A to N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria while translocating protons, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplas...

[ "GO:0016651", "GO:0051536" ]

[ "oxidoreductase activity, acting on NAD(P)H", "iron-sulfur cluster binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01973" ]

[ "NuoG" ]

[ 16918 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "7.1.1.-", "GenProp0135", "GenProp1198", "GenProp1230", "GenProp1254", "GenProp1341", "GenProp1537", "GenProp1583", "GenProp1608", "GenProp1637", "GenProp1751", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-DDI-6799198", "R-DDI-9837999", "R-DME-611105", "R-DME-6799198", "R...

[ "EC:7.1.1.-", "GP:GenProp0135", "GP:GenProp1198", "GP:GenProp1230", "GP:GenProp1254", "GP:GenProp1341", "GP:GenProp1537", "GP:GenProp1583", "GP:GenProp1608", "GP:GenProp1637", "GP:GenProp1751", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-DDI-6...

28

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "5gpn", "5gup", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6i0d", "6i1p", "6q8o", "6q8w", "6q8x", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7"...

308

[ "PUB00005074", "PUB00043561", "PUB00045437" ]

[ "1470679", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)." ]

[ 1992, 2000, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12152, 4485, 281 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 4, 1, 4, 3, 1, 2, 4, 8 ]

11

true

Family

NADH:ubiquinone oxidoreductase, subunit G

NADH_UbQ_OxRdtase_Gsu

4

IPR010230

10,230

FeS cluster assembly SUF system, ATPase SufC

FeS-cluster_ATPase_SufC

Family

20,815

false

This entry represents SufC, which acts as an ATPase in the SUF system. SufC belongs to the ATP-binding cassette transporter family ( ) but is no longer thought to be part of a transporter. The complex is reported as cytosolic or associated with the membrane [ ]. Iron-sulphur (FeS) clusters are important cofactors for n...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "PANTHER", "NCBIFAM", "CDD" ]

[ "PTHR43204", "TIGR01978", "cd03217" ]

[ "", "sufC", "ABC_FeS_Assembly" ]

[ 20776, 19355, 19911 ]

3

[ "GP", "GP" ]

[ "GenProp0137", "GenProp1192" ]

[ "GP:GenProp0137", "GP:GenProp1192" ]

2

[ "2d2e", "2d2f", "2d3w", "2zu0", "5awf", "5awg", "9h78", "9h7x", "9h7y", "9hbl" ]

10

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640", "PUB00045387" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785", "11943156" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004, 2002 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctX581", "unclassified sequences" ]

[ 931, 17965, 1365, 1, 553 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 2, 3 ]

4

true

Family

FeS cluster assembly SUF system, ATPase SufC

FeS-cluster_ATPase_SufC

4

IPR010232

10,232

Probable protein kinase UbiB

UbiB

Family

8,953

false

UbiB (also known as as AarF) is required for ubiquinone biosynthesis [ , , ]. It may function in regulating Q8 biosynthesis via its putative kinase activity [ ].

[ "GO:0006744" ]

[ "ubiquinone biosynthetic process" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM", "NCBIFAM" ]

[ "MF_00414", "NF003404", "TIGR01982" ]

[ "UbiB", "PRK04750.1", "UbiB" ]

[ 4934, 5973, 8944 ]

3

[ "GP" ]

[ "GenProp0136" ]

[ "GP:GenProp0136" ]

1

[]

0

[ "PUB00007385", "PUB00013772", "PUB00013848", "PUB00068672", "PUB00162368" ]

[ "9422602", "10960098", "11583838", "23709220", "34362905" ]

[ "Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii.", "Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthe...

[ 1998, 2000, 2001, 2013, 2021 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8843, 15, 95 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Probable protein kinase UbiB

UbiB

8

IPR010233

10,233

Ubiquinone biosynthesis O-methyltransferase

UbiG_MeTrfase

Family

14,713

false

This entry represents an O-methyltransferase, which is believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and mitochondria (COQ3) [ , ]. A separate methylase (MenG/UbiE) catalyses the single C-methylation step. The most commonly used names for genes in this family do not indicate wh...

[ "GO:0010420", "GO:0061542", "GO:0006744" ]

[ "polyprenyldihydroxybenzoate methyltransferase activity", "3-demethylubiquinol 3-O-methyltransferase activity", "ubiquinone biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00472", "TIGR01983" ]

[ "UbiG", "UbiG" ]

[ 13270, 14621 ]

2

[ "EC", "EC", "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "2.1.1.222", "2.1.1.64", "GenProp0136", "GenProp1744", "PWY-5855", "PWY-5856", "PWY-5857", "PWY-5870", "PWY-5871", "PWY-5872", "PWY-5873", "PWY-6708", "PWY-7230", "R-DDI-2142789", "R-HSA-2142789", "R-MMU-2142789", "R-RNO-2142789", "R-SCE-2142789", "R-SPO-2142789" ]

[ "EC:2.1.1", "EC:2.1.1.222", "EC:2.1.1.64", "GP:GenProp0136", "GP:GenProp1744", "METACYC:PWY-5855", "METACYC:PWY-5856", "METACYC:PWY-5857", "METACYC:PWY-5870", "METACYC:PWY-5871", "METACYC:PWY-5872", "METACYC:PWY-5873", "METACYC:PWY-6708", "METACYC:PWY-7230", "REACTOME:R-DDI-2142789", "...

20

[ "4kdc", "4kdr", "5dpm" ]

3

[ "PUB00013843", "PUB00013848" ]

[ "10419476", "11583838" ]

[ "Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.", "Ubiquinone biosynthesis in microorganisms." ]

[ 1999, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9927, 4652, 134 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 1, 1, 4, 1, 2, 3, 1, 7, 3, 1, 1, 19 ]

13

true

Family

Ubiquinone biosynthesis O-methyltransferase

UbiG_MeTrfase

8

IPR010236

10,236

ISC system FeS cluster assembly, HscA chaperone

ISC_FeS_clus_asmbl_HscA

Family

5,776

false

This entry represents the HscA chaperone protein from the SUF system. HscA (or Hsc66) is a specialised bacterial Hsp70-class molecular chaperone that participates in the assembly of iron-sulphur cluster proteins. HscA resembles DnaK, but belongs to a separate clade. HscA interacts with IscU, which is believed to serve ...

[ "GO:0005524", "GO:0016887", "GO:0051082", "GO:0006457", "GO:0016226" ]

[ "ATP binding", "ATP hydrolysis activity", "unfolded protein binding", "protein folding", "iron-sulfur cluster assembly" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_00679", "TIGR01991" ]

[ "HscA", "HscA" ]

[ 5555, 5739 ]

2

[ "GP" ]

[ "GenProp0138" ]

[ "GP:GenProp0138" ]

1

[]

0

[ "PUB00003442", "PUB00014905", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "15100228", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Preferential substrate binding orientation by the molecular chaperone HscA.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S...

[ 1996, 2004, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

9

[ "IPR013126" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5707, 7, 62 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ISC system FeS cluster assembly, HscA chaperone

ISC_FeS_clus_asmbl_HscA

8

IPR010237

10,237

Pyrimidine 5-nucleotidase

Pyr-5-nucltdase

Family

8,591

false

This family of proteins includes the SDT1/SSM1 gene from yeast, which has been shown to code for a pyrimidine (UMP/CMP) 5'nucleotidase [ , ]. The family spans plants, fungi and bacteria. These enzymes are members of the haloacid dehalogenase (HAD) superfamily of hydrolases, specifically the IA subfamily.

[]

0

[ "SFLD", "NCBIFAM", "CDD" ]

[ "SFLDG01132", "TIGR01993", "cd02604" ]

[ "C1.5.3:_5'-Nucleotidase_Like", "Pyr-5-nucltdase", "HAD_5NT" ]

[ 7873, 8320, 2460 ]

3

[]

0

[ "3nuq", "3onn", "3opx", "7ef6", "7ef7" ]

5

[ "PUB00017734", "PUB00090511" ]

[ "11934891", "21268116" ]

[ "SDT1/SSM1, a multicopy suppressor of S-II null mutant, encodes a novel pyrimidine 5'-nucleotidase.", "Crystal structure of the pyrimidine 5'-nucleotidase SDT1 from Saccharomyces cerevisiae complexed with uridine 5'-monophosphate provides further insight into ligand binding." ]

[ 2002, 2011 ]

2

[ "IPR006439" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3718, 4824, 49 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 26, 1, 11, 2, 1, 26 ]

6

true

Family

Pyrimidine 5-nucleotidase

Pyr-5-nucltdase

3

IPR010238

10,238

NIF system FeS cluster assembly, NifU

NIF_FeS_clus_asmbl_NifU

Family

899

false

This entry represents the NifU protein from the NIF system that is involved in nitrogenase maturation. Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend ...

[ "GO:0005506", "GO:0051536", "GO:0016226" ]

[ "iron ion binding", "iron-sulfur cluster binding", "iron-sulfur cluster assembly" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02000" ]

[ "NifU_proper" ]

[ 899 ]

1

[ "GP" ]

[ "GenProp0742" ]

[ "GP:GenProp0742" ]

1

[]

0

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

8

[ "IPR016217" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 880, 19 ]

2

[]

0

true

Family

NIF system FeS cluster assembly, NifU

NIF_FeS_clus_asmbl_NifU

2

IPR010239

10,239

Conserved hypothetical protein CHP02001

CHP02001

Family

7,037

false

This entry represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis and Ralstonia solanacearum, usually as part of a paralogous family. The function is unknown.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09694", "TIGR02001" ]

[ "Gcw_chp", "gcw_chp" ]

[ 6994, 6453 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 6916, 4, 16, 101 ]

4

[]

0

true

Family

Conserved hypothetical protein CHP02001

CHP02001

4

IPR010240

10,240

Cysteine desulfurase IscS

Cys_deSase_IscS

Family

11,623

false

This entry represents cysteine deusulfurase (IscS), one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulphur cluster assembly [ , , ]. In M. tubercu...

[ "GO:0030170", "GO:0031071", "GO:0044571" ]

[ "pyridoxal phosphate binding", "cysteine desulfurase activity", "[2Fe-2S] cluster assembly" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00331", "TIGR02006" ]

[ "Cys_desulf_IscS", "IscS" ]

[ 11616, 8781 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME",...

[ "2.8.1.7", "GenProp0138", "GenProp0704", "GenProp1144", "GenProp1163", "GenProp1197", "GenProp1313", "GenProp1333", "GenProp1461", "GenProp1555", "GenProp1711", "PWY-6823", "PWY-6892", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-8165", "PWY-8452", "R-DDI-1362409", "R-DDI-947581", ...

[ "EC:2.8.1.7", "GP:GenProp0138", "GP:GenProp0704", "GP:GenProp1144", "GP:GenProp1163", "GP:GenProp1197", "GP:GenProp1313", "GP:GenProp1333", "GP:GenProp1461", "GP:GenProp1555", "GP:GenProp1711", "METACYC:PWY-6823", "METACYC:PWY-6892", "METACYC:PWY-7250", "METACYC:PWY-7892", "METACYC:PWY...

41

[ "1p3w", "3lvj", "3lvk", "3lvl", "3lvm", "4eb5", "4eb7", "4hvk", "4r5f", "5kz5", "5usr", "5wgb", "5wkp", "5wlw", "5wt2", "5wt4", "5wt5", "5wt6", "6kg0", "6kg1", "6nzu", "6uxe", "6w1d", "6wi2", "6wih", "7cet", "7ceu", "7rtk", "7xeq", "7xes", "8pk8", "8pk9"...

40

[ "PUB00021001", "PUB00043028", "PUB00095247" ]

[ "14978044", "16387657", "24548275" ]

[ "Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo.", "Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions.", "The cysteine desulfurase Isc...

[ 2004, 2006, 2014 ]

3

[ "IPR016454" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 193, 7383, 3970, 77 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 3, 1, 1, 1, 1, 4, 2, 1, 2, 4, 1, 1, 5 ]

13

true

Family

Cysteine desulfurase IscS

Cys_deSase_IscS

2

IPR010241

10,241

Ferredoxin [2Fe-2S], plant and bacteria

2Fe-2S_ferredoxin

Domain

5,758

false

2Fe-2S (also called plant type) ferredoxins occur as single-domain proteins or with a chloroplast transit peptide. In higher plants, ferredoxin is the unique soluble electron carrier protein located in the stroma, and a wide variety of essential metabolic and signalling processes depend upon the reduction by ferredoxin...

[ "GO:0009055", "GO:0051537", "GO:0022900" ]

[ "electron transfer activity", "2 iron, 2 sulfur cluster binding", "electron transport chain" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02008" ]

[ "fdx_plant" ]

[ 5758 ]

1

[]

0

[ "1a70", "1awd", "1czp", "1dox", "1doy", "1ewy", "1frd", "1frr", "1fxa", "1fxi", "1gaq", "1iue", "1j7a", "1j7b", "1j7c", "1off", "1pfd", "1qoa", "1qob", "1qof", "1qog", "1qt9", "1rfk", "1roe", "1wri", "2cjn", "2cjo", "2kaj", "2mh7", "2n0s", "2pvg", "2pvo"...

80

[ "PUB00001617", "PUB00014946", "PUB00017893" ]

[ "2065785", "14684843", "8586613" ]

[ "Divergent evolution of chloroplast-type ferredoxins.", "A post genomic characterization of Arabidopsis ferredoxins.", "Tertiary structure of [2Fe-2S] ferredoxin from Spirulina platensis refined at 2.5 A resolution: structural comparisons of plant-type ferredoxins and an electrostatic potential analysis." ]

[ 1991, 2004, 1995 ]

3

[ "IPR001041" ]

[]

1

0

1

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 1616, 54, 3904, 182, 2 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 19, 35 ]

3

true

Domain

Ferredoxin [2Fe-2S], plant and bacteria

2Fe-2S_ferredoxin

6

IPR010242

10,242

Transcription factor HTH, IscR

TF_HTH_IscR

Family

4,259

false

This entry describes IscR, an iron-sulphur binding transcription factor of the ISC iron-sulphur cluster assembly system [ ]. The HTH-type transcriptional regulator IscR (iron-sulphur cluster regulator) regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containi...

[ "GO:0003690", "GO:0003700", "GO:0006355" ]

[ "double-stranded DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01176", "TIGR02010" ]

[ "HTH_type_IscR", "IscR" ]

[ 1192, 4253 ]

2

[ "GP" ]

[ "GenProp0138" ]

[ "GP:GenProp0138" ]

1

[]

0

[ "PUB00003442", "PUB00028014", "PUB00033785", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640", "PUB00043090", "PUB00054980" ]

[ "8875867", "11498000", "11742080", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785", "16677314", "16824106" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins...

[ 1996, 2001, 2001, 2005, 2005, 2006, 2005, 2007, 2004, 2006, 2006 ]

11

[ "IPR000944" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4224, 2, 33 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription factor HTH, IscR

TF_HTH_IscR

2

IPR010243

10,243

DNA-directed RNA polymerase beta subunit, bacterial-type

RNA_pol_bsu_bac

Family

41,063

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01321", "TIGR02013" ]

[ "RNApol_bact_RpoB", "rpoB" ]

[ 40548, 26284 ]

2

[ "EC", "GP", "REACTOME" ]

[ "2.7.7.6", "GenProp0262", "R-HSA-9639775" ]

[ "EC:2.7.7.6", "GP:GenProp0262", "REACTOME:R-HSA-9639775" ]

3

[ "1hqm", "1i6v", "1iw7", "1l9u", "1l9z", "1smy", "1ynj", "1ynn", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2gho", "2o5i", "2o5j", "2ppb", "3aoh", "3aoi", "3dxj", "3eql", "3iyd", "3lu0", "3wod", "4g7h", "4g7o", "4g7z", "4gzy", "4gzz", "4jk1"...

648

[ "PUB00000061", "PUB00033173" ]

[ "3052291", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 1999 ]

2

[ "IPR015712" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26308, 14461, 294 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 5, 4 ]

4

true

Family

DNA-directed RNA polymerase beta subunit, bacterial-type

RNA_pol_bsu_bac

4

IPR010244

10,244

Chlorophyllide reductase subunit Z

BchZ

Family

664

false

This entry represents the Z subunit of the three-subunit enzyme, bacteriochlorophyllide reductase [ , ]. This enzyme is responsible for the reduction of the chlorin B-ring and is closely related to the protochlorophyllide reductase complex which reduces the D-ring. Both of these complexes in turn are homologous to nitr...

[ "GO:0016730", "GO:0030494" ]

[ "oxidoreductase activity, acting on iron-sulfur proteins as donors", "bacteriochlorophyll biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02014" ]

[ "BchZ" ]

[ 664 ]

1

[ "EC", "GP", "METACYC" ]

[ "1.3.7.15", "GenProp0146", "PWY-5526" ]

[ "EC:1.3.7.15", "GP:GenProp0146", "METACYC:PWY-5526" ]

3

[]

0

[ "PUB00002215", "PUB00013798" ]

[ "8468299", "10648776" ]

[ "The Rhodobacter capsulatus chlorin reductase-encoding locus, bchA, consists of three genes, bchX, bchY, and bchZ.", "DNA sequence analysis of the photosynthesis region of Rhodobacter sphaeroides 2.4.1." ]

[ 1993, 2000 ]

2

[ "IPR016209" ]

[]

1

0

1

[ "Bacteria", "Effrenium voratum", "freshwater sediment metagenome" ]

[ 662, 1, 1 ]

3

[]

0

true

Family

Chlorophyllide reductase subunit Z

BchZ

5

IPR010245

10,245

Chlorophyllide reductase subunit Y

BchY

Family

679

false

This entry represents the Y subunit of the three-subunit enzyme, (bacterio)chlorophyllide reductase [ , ]. This enzyme is responsible for the reduction of the chlorin B-ring and is closely related to the protochlorophyllide reductase complex which reduces the D-ring. Both of these complexes in turn are homologous to ni...

[ "GO:0016731", "GO:0015979", "GO:0030494", "GO:0016020" ]

[ "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor", "photosynthesis", "bacteriochlorophyll biosynthetic process", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02015" ]

[ "BchY" ]

[ 679 ]

1

[ "GP" ]

[ "GenProp0146" ]

[ "GP:GenProp0146" ]

1

[]

0

[ "PUB00002215", "PUB00013798" ]

[ "8468299", "10648776" ]

[ "The Rhodobacter capsulatus chlorin reductase-encoding locus, bchA, consists of three genes, bchX, bchY, and bchZ.", "DNA sequence analysis of the photosynthesis region of Rhodobacter sphaeroides 2.4.1." ]

[ 1993, 2000 ]

2

[ "IPR016209" ]

[]

1

0

1

[ "Bacteria", "freshwater sediment metagenome" ]

[ 678, 1 ]

2

[]

0

true

Family

Chlorophyllide reductase subunit Y

BchY

1

IPR010246

10,246

Chlorophyllide reductase iron protein subunit X

BchX

Family

676

false

This entry represents the X subunit of the three-subunit enzyme, (bacterio)chlorophyllide reductase [ , ]. This enzyme is responsible for the reduction of the chlorin B-ring and is closely related to the protochlorophyllide reductase complex which reduces the D-ring. Both of these complexes in turn are homologous to ni...

[ "GO:0005524", "GO:0016628", "GO:0051539", "GO:0015979", "GO:0030494" ]

[ "ATP binding", "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "4 iron, 4 sulfur cluster binding", "photosynthesis", "bacteriochlorophyll biosynthetic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02016" ]

[ "BchX" ]

[ 676 ]

1

[ "GP" ]

[ "GenProp0146" ]

[ "GP:GenProp0146" ]

1

[]

0

[ "PUB00002215", "PUB00013798" ]

[ "8468299", "10648776" ]

[ "The Rhodobacter capsulatus chlorin reductase-encoding locus, bchA, consists of three genes, bchX, bchY, and bchZ.", "DNA sequence analysis of the photosynthesis region of Rhodobacter sphaeroides 2.4.1." ]

[ 1993, 2000 ]

2

[ "IPR000392" ]

[]

1

0

1

[ "Bacteria", "freshwater sediment metagenome" ]

[ 675, 1 ]

2

[]

0

true

Family

Chlorophyllide reductase iron protein subunit X

BchX

6

IPR010247

10,247

N-formylglutamate deformylase

HutG_amidohyd

Family

4,023

false

In some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate may differ, with the next enzyme being formiminoglutamate hy...

[]

0

[ "NCBIFAM" ]

[ "TIGR02017" ]

[ "hutG_amidohyd" ]

[ 4023 ]

1

[]

0

[]

0

[ "PUB00013521" ]

[ "2842309" ]

[ "Organization and multiple regulation of histidine utilization genes in Pseudomonas putida." ]

[ 1988 ]

1

[ "IPR007709" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4001, 3, 19 ]

3

[]

0

true

Family

N-formylglutamate deformylase

HutG_amidohyd

4

IPR010249

10,249

Bacteriochlorophyll 4-vinyl reductase

BchJ

Family

379

false

This entry represents the component of bacteriochlorophyll synthetase responsible for reduction of the B-ring pendant ethylene (4-vinyl) group. It appears that this step must precede the reduction of ring D, at least by the 'dark' protochlorophyllide reductase enzymes BchN, BchB and BchL [ ]. This family appears to be ...

[ "GO:0015979", "GO:0030494" ]

[ "photosynthesis", "bacteriochlorophyll biosynthetic process" ]

[ "biological_process", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02019" ]

[ "BchJ" ]

[ 379 ]

1

[ "GP" ]

[ "GenProp0144" ]

[ "GP:GenProp0144" ]

1

[]

0

[ "PUB00013771" ]

[ "7876113" ]

[ "Altered monovinyl and divinyl protochlorophyllide pools in bchJ mutants of Rhodobacter capsulatus. Possible monovinyl substrate discrimination of light-independent protochlorophyllide reductase." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Chlorarachniophyceae", "freshwater sediment metagenome" ]

[ 375, 3, 1 ]

3

[]

0

true

Family

Bacteriochlorophyll 4-vinyl reductase

BchJ

1

IPR010251

10,251

Magnesium-protoporphyrin IX methyltransferase

Mg_prot_MeTrfase

Family

1,685

false

This entry represents magnesium-protoporphyrin IX methyltransferase ( ). This converts magnesium-protoporphyrin IX to magnesium-protoporphyrin IX metylester using S-adenosyl-L-methionine as a cofactor [ ], which represents the second committed step in the biosynthesis of chlorophyll and bacteriochlorophyll from protopo...

[ "GO:0046406", "GO:0015995" ]

[ "magnesium protoporphyrin IX methyltransferase activity", "chlorophyll biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PROFILE", "NCBIFAM" ]

[ "PS51556", "TIGR02021" ]

[ "SAM_MT_MG_PIX", "BchM-ChlM" ]

[ 1633, 1677 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.1.1.11", "GenProp0144", "PWY-5531", "PWY-7159" ]

[ "EC:2.1.1.11", "GP:GenProp0144", "METACYC:PWY-5531", "METACYC:PWY-7159" ]

4

[ "4qdj", "4qdk" ]

2

[ "PUB00013004", "PUB00034718", "PUB00034719" ]

[ "8071204", "7925960", "12489983" ]

[ "Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase.", "The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methy...

[ 1994, 1994, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "freshwater sediment metagenome" ]

[ 1049, 635, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 3, 2 ]

3

true

Family

Magnesium-protoporphyrin IX methyltransferase

Mg_prot_MeTrfase

7

IPR010252

10,252

Formimidoylglutamate deiminase

HutF

Family

6,443

false

In some species, histidine utilisation goes via urocanate to glutamate in four step, the last being removal of formamide. This entry describes an alternate fourth step, formimidoylglutamate deiminase which leads to N-formyl-L-glutamate [ , ]. This product may be acted on by formylglutamate amidohydrolase ( ) and bypass...

[]

0

[ "NCBIFAM" ]

[ "TIGR02022" ]

[ "hutF" ]

[ 6443 ]

1

[]

0

[ "3mdu", "3mdw", "4f0l", "4rdv", "4rdw", "4rzb" ]

6

[ "PUB00101363", "PUB00101364" ]

[ "17128965", "16475788" ]

[ "Mechanistic characterization of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa.", "Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily." ]

[ 2006, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6404, 5, 34 ]

3

[]

0

true

Family

Formimidoylglutamate deiminase

HutF

5

IPR010253

10,253

Geranylgeranyl reductase, plant/prokaryotic

BchP_ChlP_pln/prok

Family

2,188

false

This entry represents a group of geranylgeranyl reductases specific for the biosyntheses of bacteriochlorophyll and chlorophyll [ ]. It is unclear whether the processes of isoprenoid ligation to the chlorin ring and reduction of the geranylgeranyl chain to a phytyl chain are necessarily ordered the same way in all spec...

[ "GO:0045550", "GO:0015979", "GO:0015995" ]

[ "geranylgeranyl reductase activity", "photosynthesis", "chlorophyll biosynthetic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02023" ]

[ "BchP-ChlP" ]

[ 2188 ]

1

[ "EC", "GP", "GP", "GP" ]

[ "1.3.1.83", "GenProp0146", "GenProp1355", "GenProp1382" ]

[ "EC:1.3.1.83", "GP:GenProp0146", "GP:GenProp1355", "GP:GenProp1382" ]

4

[]

0

[ "PUB00013768", "PUB00013815" ]

[ "10398704", "10572128" ]

[ "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase", "Physical mapping and functional assignment of the geranylgeranyl-bacteriochlorophyll reduc...

[ 1999, 1999 ]

2

[ "IPR011777" ]

[ "IPR011774" ]

1

0

[ "Bacteria", "Eukaryota", "freshwater sediment metagenome" ]

[ 1022, 1165, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 5, 5 ]

3

true

Family

Geranylgeranyl reductase, plant/prokaryotic

BchP_ChlP_pln/prok

9

IPR010255

10,255

Haem peroxidase superfamily

Haem_peroxidase_sf

Homologous_superfamily

114,071

false

Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Most haem peroxidases follow the reaction scheme: Fe 3+ + H 2 O 2 -->[Fe 4+ =O]R' (Compound I) + H 2 O [Fe 4+ =O]R' + substrate -->[Fe 4+ =O]R (Compound II) + oxidised substrate [Fe 4...

[ "GO:0004601", "GO:0020037", "GO:0006979" ]

[ "peroxidase activity", "heme binding", "response to oxidative stress" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "SSF" ]

[ "SSF48113" ]

[ "" ]

[ 114071 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.11.1", "R-BTA-8941413", "R-CEL-209968", "R-CEL-6798695", "R-CEL-8941413", "R-CFA-140180", "R-CFA-209968", "R-CFA-2162123", "R-DDI-209968", "R-DDI-6798695", "R-DDI-8941413", "R-DME-209968", "R-DME-6798695", "R-DME-8941413", "R-GGA-2142770", "R-GGA-2162123", "R-GGA-9018677", "R-GG...

[ "EC:1.11.1", "REACTOME:R-BTA-8941413", "REACTOME:R-CEL-209968", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8941413", "REACTOME:R-CFA-140180", "REACTOME:R-CFA-209968", "REACTOME:R-CFA-2162123", "REACTOME:R-DDI-209968", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-8941413", "REACTOME:R-DME-209968", ...

56

[ "1a2f", "1a2g", "1aa4", "1ac4", "1ac8", "1aeb", "1aed", "1aee", "1aef", "1aeg", "1aeh", "1aej", "1aek", "1aem", "1aen", "1aeo", "1aeq", "1aes", "1aet", "1aeu", "1aev", "1apx", "1arp", "1aru", "1arv", "1arw", "1arx", "1ary", "1atj", "1b80", "1b82", "1b85"...

736

[ "PUB00001259", "PUB00004979", "PUB00005246", "PUB00013944" ]

[ "8062820", "2840655", "7922023", "10403190" ]

[ "Peroxidasin: a novel enzyme-matrix protein of Drosophila development.", "Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family.", "Structural variation in heme enzymes: a comparative analysis of p...

[ 1994, 1988, 1994, 1999 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 460, 18004, 95287, 13, 307 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 374, 14, 38, 23, 1, 46, 30, 7, 538, 35, 1, 653 ]

12

true

Homologous_superfamily

Haem peroxidase superfamily

Haem_peroxidase_sf

1

IPR010258

10,258

Conjugal transfer TrbG/VirB9/CagX

TrbG/VirB9/CagX

Family

8,892

false

Several bacterial pathogens utilise conjugation machines to export effector molecules during infection. Such systems are members of the type IV or 'adapted conjugation' secretion family. The prototypical type IV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein parti...

[]

0

[ "PFAM" ]

[ "PF03524" ]

[ "CagX" ]

[ 8892 ]

1

[]

0

[ "2n01", "2ofq", "2ypw", "3jqo", "3zbi", "3zbj", "5h3v", "6gyb", "6oeg", "6x6j", "6x6k", "6x6l", "6x6s", "7o3j", "7o3t", "8cb2", "8rt4", "8rt5", "8rt6", "8rt7", "8rt8" ]

21

[ "PUB00007668" ]

[ "10920394" ]

[ "Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells." ]

[ 2000 ]

1

[]

[ "IPR004357", "IPR014142", "IPR014148" ]

0

3

0

[ "Bacteria", "Eukaryota", "metagenomes", "plasmids", "uncultured Caudovirales phage" ]

[ 8761, 58, 63, 9, 1 ]

5

[]

0

true

Family

Conjugal transfer TrbG/VirB9/CagX

TrbG/VirB9/CagX

4

IPR010259

10,259

Peptidase S8 propeptide/proteinase inhibitor I9

S8pro/Inhibitor_I9

Domain

48,096

false

Proteinase propeptide inhibitors (sometimes refered to as activation peptides) are responsible for the modulation of folding and activity of the pro-enzyme or zymogen. The pro-segment docks into the enzyme moiety shielding the substrate binding site, thereby promoting inhibition of the enzyme. Several such propeptides ...

[]

0

[ "PFAM" ]

[ "PF05922" ]

[ "Inhibitor_I9" ]

[ 48096 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.21", "3.4.21.-", "PWY-7884", "R-HSA-381426", "R-HSA-8866427", "R-HSA-8957275", "R-HSA-8964038", "R-MMU-381426", "R-MMU-8866427", "R-MMU-8957275", "R-MMU-8964038", "R-RNO-381426", "R-RNO-8866427", "R-RNO-8957275", "R-RNO-8964038", "R-SCE-8866427", "R-SCE-8964038", "R-SPO-886642...

[ "EC:3.4.21", "EC:3.4.21.-", "METACYC:PWY-7884", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8866427", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-8964038", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8866427", "REACTOME:R-MMU-8957275", "REACTOME:R-MMU-8964038", "REACTOME:R-RNO-381426", "REACTOME:R-R...

19

[ "1scj", "2p4e", "2pmw", "2qtw", "2w2m", "2w2n", "2w2o", "2w2p", "2w2q", "2xtj", "3bgo", "3bps", "3cnq", "3co0", "3gcw", "3gcx", "3h42", "3m0c", "3p5b", "3p5c", "3sqo", "3whi", "4k8r", "4ne9", "4nmx", "4ov6", "4yn3", "5oca", "5vl7", "5vla", "5vlh", "5vlk"...

71

[ "PUB00011742", "PUB00011744", "PUB00045005" ]

[ "9811547", "12095256", "7559646" ]

[ "The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution.", "Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.", "Functional analysis of the propeptide of subtilisin E as an intramolecular chaperone for protein folding. Refolding and...

[ 1998, 2002, 1995 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 39, 10626, 37373, 58 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 248, 3, 7, 1, 4, 157, 2, 2, 3, 199 ]

10

true

Domain

Peptidase S8 propeptide/proteinase inhibitor I9

S8pro/Inhibitor_I9

1

IPR010260

10,260

DNA-binding transcriptional activator AlpA

AlpA

Family

14,236

false

This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppresses two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light. AlpA acts as a transcriptional regulator of the slpA gene; activation of...

[]

0

[ "PFAM" ]

[ "PF05930" ]

[ "Phage_AlpA" ]

[ 14236 ]

1

[]

0

[ "8c3t" ]

1

[ "PUB00011917" ]

[ "7511582" ]

[ "Alp suppression of Lon: dependence on the slpA gene." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 14050, 14, 40, 132 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA-binding transcriptional activator AlpA

AlpA

4

IPR010261

10,261

Tir chaperone protein (CesT) family

Tir_chaperone

Family

4,585

false

This family consists of a number of sequences which are highly similar to the Tir chaperone protein in Escherichia coli. In many Gram-negative bacteria, a key indicator of pathogenic potential is the possession of a specialised type III secretion system, which is utilised to deliver virulence effector proteins directly...

[ "GO:0030254" ]

[ "protein secretion by the type III secretion system" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05932" ]

[ "CesT" ]

[ 4585 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "1jya", "1jyo", "1k3e", "1k6z", "1l2w", "1n5b", "1s28", "1ttw", "1xkp", "2bho", "2bsh", "2bsi", "2bsj", "3epu", "3kxy", "4g6t", "4gf3", "4jmf", "5wez", "5z38", "6jnp", "7eva", "9uwz", "9ux0" ]

24

[ "PUB00011919", "PUB00012801", "PUB00057254", "PUB00094247" ]

[ "11849537", "9448330", "9642193", "16714561" ]

[ "Functional analysis of the enteropathogenic Escherichia coli type III secretion system chaperone CesT identifies domains that mediate substrate interactions.", "Homology and functional similarity of an hrp-linked pathogenicity locus, dspEF, of Erwinia amylovora and the avirulence locus avrE of Pseudomonas syring...

[ 2002, 1998, 1998, 2006 ]

4

[]

[ "IPR005416", "IPR013353", "IPR044530" ]

0

3

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4434, 143, 8 ]

3

[]

0

true

Family

Tir chaperone protein (CesT) family

Tir_chaperone

5

IPR010262

10,262

Arylsulfotransferase, bacteria

Arylsulfotransferase_bact

Family

6,877

false

This entry represents a group of arylsulphotransferase (ASST) mostly from bacteria. It transfers a sulphate group from phenolic sulphate esters to a phenolic acceptor substrate [ ].

[ "GO:0004062" ]

[ "aryl sulfotransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05935" ]

[ "Arylsulfotrans" ]

[ 6877 ]

1

[]

0

[ "3elq", "3ets", "3ett", "4p04", "4p05", "4p06", "4p07" ]

7

[ "PUB00011921" ]

[ "8887346" ]

[ "Cloning and sequencing of the Klebsiella K-36 astA gene, encoding an arylsulfate sulfotransferase." ]

[ 1996 ]

1

[]

[ "IPR028610" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Virus NIOZ-UU157", "unclassified sequences" ]

[ 305, 6174, 244, 1, 153 ]

5

[]

0

true

Family

Arylsulfotransferase, bacteria

Arylsulfotransferase_bact

4

IPR010264

10,264

Plant self-incompatibility S1

Self-incomp_S1

Family

9,770

false

This family consists of a series of plant proteins which are related to the Papaver rhoeas S1 self-incompatibility protein. Self-incompatibility (SI) is the single most important outbreeding device found in angiosperms and is a mechanism that regulates the acceptance or rejection of pollen. S1 is known to exhibit speci...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05938", "PTHR31232" ]

[ "Self-incomp_S1", "" ]

[ 9769, 7865 ]

2

[]

0

[ "6g7g" ]

1

[ "PUB00011923" ]

[ "8134385" ]

[ "Cloning and expression of a distinctive class of self-incompatibility (S) gene from Papaver rhoeas L." ]

[ 1994 ]

1

[]

0

null

[ "Eukaryota" ]

[ 9770 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans" ]

[ 200, 3 ]

2

true

Family

Plant self-incompatibility S1

Self-incomp_S1

5

IPR010265

10,265

Bacteriophage lambda, Tail tip protein M

Phage_lambda_TipM

Family

3,231

false

This entry represents Tail tip protein M from Escherichia phage lambda (Bacteriophage lambda). Members of this protein family are found in tailed bacteriophages (Caudovirales) and in bacterial prophages mostly among Proteobacteria. TipM is part of the distal tail tip which plays a role in DNA ejection during entry, and...

[]

0

[ "PFAM" ]

[ "PF05939" ]

[ "Phage_min_tail" ]

[ 3231 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "8iyk", "8iyl", "8k35", "8xcg", "9e7m", "9l9p" ]

6

[ "PUB00077057" ]

[ "1003470" ]

[ "Morphogenesis of bacteriophage lambda tail. Polymorphism in the assembly of the major tail protein." ]

[ 1976 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "Viruses", "metagenomes" ]

[ 2808, 5, 407, 11 ]

4

[]

0

true

Family

Bacteriophage lambda, Tail tip protein M

Phage_lambda_TipM

4

IPR010266

10,266

NnrS

Family

5,886

false

This family consists of several bacterial NnrS like proteins. NnrS is a haem-Cu protein (NnrS) and a member of the short-chain dehydrogenase family [ ]. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide,...

[]

0

[ "PFAM" ]

[ "PF05940" ]

[ "NnrS" ]

[ 5886 ]

1

[]

0

[]

0

[ "PUB00011924", "PUB00011925", "PUB00098477", "PUB00098478" ]

[ "12618453", "11882718", "22511349", "23935055" ]

[ "Operon structure and regulation of the nos gene region of Pseudomonas stutzeri, encoding an ABC-Type ATPase for maturation of nitrous oxide reductase.", "Characterization of a member of the NnrR regulon in Rhodobacter sphaeroides 2.4.3 encoding a haem-copper protein.", "The NorR regulon is critical for Vibrio ...

[ 2003, 2002, 2012, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Ferroplasma acidiphilum", "unclassified sequences" ]

[ 5780, 2, 1, 103 ]

4

[]

0

true

Family

NnrS

7

IPR010267

10,267

Chordopoxvirus A20R

Chordopox_A20R

Family

165

false

This family consists of several Chordopoxvirus A20R proteins. The A20R protein, also known as DNA polymerase processivity factor component OPG148, plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116 [ ]. It serves as a bridge which links the DNA ...

[]

0

[ "PFAM" ]

[ "PF05941" ]

[ "Chordopox_A20R" ]

[ 165 ]

1

[]

0

[ "4od8", "4oda", "4ygm", "4yig", "5jkr", "5jks", "5jkt", "8hdz", "8hg1", "8hlz", "8hm0", "8hoy", "8hpa", "8j86", "8j8f", "8j8g", "8k8s", "8k8u", "8q3r", "8wpe", "8wpf", "8wpk", "8wpp", "9k9r", "9k9s", "9k9t", "9k9u", "9k9v" ]

28

[ "PUB00011926", "PUB00103661", "PUB00103662", "PUB00103663" ]

[ "12490386", "20861259", "11711620", "16326701" ]

[ "Mapping interaction sites of the A20R protein component of the vaccinia virus DNA replication complex.", "Vaccinia virus D4 mutants defective in processive DNA synthesis retain binding to A20 and DNA.", "The A20R protein is a stoichiometric component of the processive form of vaccinia virus DNA polymerase.", ...

[ 2002, 2010, 2001, 2006 ]

4

[]

0

null

[ "Poxviridae" ]

[ 165 ]

1

[]

0

true

Family

Chordopoxvirus A20R

Chordopox_A20R

5

IPR010268

10,268

Archaeal PaREP1-like

PaREP1-like

Domain

1,116

false

This is a domain found in several archaeal PaREP1 proteins, whose function is unknown.

[]

0

[ "PFAM" ]

[ "PF05942" ]

[ "PaREP1" ]

[ 1116 ]

1

[]

0

[ "2jpu", "2q00" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1058, 15, 39, 4 ]

4

[]

0

true

Domain

Archaeal PaREP1-like

PaREP1-like

9

IPR010269

10,269

Type VI secretion system TssC-like

T6SS_TssC-like

Family

9,087

false

The long cytoplasmic tubular structure of the T6SS system is wrapped by a sheath structure composed of two proteins, TssB and TssC. Contraction of the sheath causes the internal tube of the T6SS with associated effectors to be propelled out of the effector cell and across the membranes of bacterial or eukaryotic target...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR35565", "TIGR03355" ]

[ "", "VI_chp_2" ]

[ 9086, 8141 ]

2

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "3j9g", "3j9o", "5mxn", "5myu", "5n8n", "5ojq", "5urw", "5urx", "9n4v" ]

9

[ "PUB00075434", "PUB00093972", "PUB00093973", "PUB00093981", "PUB00094011", "PUB00094013", "PUB00094016", "PUB00094017", "PUB00094018", "PUB00160456" ]

[ "24381728", "27288401", "31379775", "29307484", "26370934", "23341461", "24282569", "25723168", "28947741", "39546591" ]

[ "The rise of the Type VI secretion system.", "TssA forms a gp6-like ring attached to the type VI secretion sheath.", "Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.", "Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.", "Type VI secretion s...

[ 2013, 2016, 2019, 2018, 2015, 2013, 2013, 2015, 2017, 2024 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9009, 19, 59 ]

3

[]

0

true

Family

Type VI secretion system TssC-like

T6SS_TssC-like

2

IPR010270

10,270

Bacteriophage P2, GpM

Phage_P2_GpM

Family

3,619

false

This entry is represented by Bacteriophage P2, GpM. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several phage small terminase subunit proteins as well as some related bacterial sequences [ ]. M protein is probably an endonuclease whi...

[ "GO:0003677", "GO:0004519", "GO:0019069" ]

[ "DNA binding", "endonuclease activity", "viral capsid assembly" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05944" ]

[ "Phage_term_smal" ]

[ 3619 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00011914" ]

[ "1837355" ]

[ "Nucleotide sequence of the DNA packaging and capsid synthesis genes of bacteriophage P2." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 3440, 4, 166, 9 ]

4

[]

0

true

Family

Bacteriophage P2, GpM

Phage_P2_GpM

5

IPR010271

10,271

Toxin-coregulated pilus subunit TcpA

TcpA

Family

215

false

This family consists of toxin-coregulated pilus subunit (TcpA) proteins from Vibrio cholerae and related sequences. The major virulence factors of toxigenic V. cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonisation factor whi...

[ "GO:0009289", "GO:0043230" ]

[ "pilus", "extracellular organelle" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05946" ]

[ "TcpA" ]

[ 215 ]

1

[]

0

[ "1oqv", "3hrv", "3s0t", "3vor", "8uhf", "9iuf" ]

6

[ "PUB00011927" ]

[ "12540588" ]

[ "Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island." ]

[ 2003 ]

1

[]

0

null

[ "Affertcholeramvirus CTXphi", "Bacteria" ]

[ 5, 210 ]

2

[]

0

true

Family

Toxin-coregulated pilus subunit TcpA

TcpA

3

IPR010272

10,272

Type VI secretion system TssF

T6SS_TssF

Family

10,059

false

This entry represents a group of Gram-negative bacterial proteins that form part of the type VI pathogenicity secretion system (T6SS), including TssF [ ]. TssF is an essential baseplate component of the type VI secretion system. TssF is a homologue of phage tail proteins and is required for proper assembly of the Hcp t...

[]

0

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF05947", "PIRSF028304", "PTHR35370", "TIGR03359" ]

[ "T6SS_TssF", "UCP028304", "", "VI_chp_6" ]

[ 10059, 8304, 9469, 8785 ]

4

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "6giy", "6gj1", "6n38" ]

3

[ "PUB00075434", "PUB00077772", "PUB00093972", "PUB00093973", "PUB00093988", "PUB00160456" ]

[ "24381728", "26460929", "27288401", "31379775", "30568167", "39546591" ]

[ "The rise of the Type VI secretion system.", "The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization.", "TssA forms a gp6-like ring attached to the type VI secretion sheath.", ...

[ 2013, 2015, 2016, 2019, 2018, 2024 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9981, 16, 62 ]

3

[]

0

true

Family

Type VI secretion system TssF

T6SS_TssF

3

IPR010273

10,273

Protein of unknown function DUF881

DUF881

Family

10,769

false

This family consists of a series of hypothetical bacterial proteins. One of the family members from Bacillus subtilis is thought to be involved in cell division and sporulation [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05949", "PTHR37313" ]

[ "DUF881", "" ]

[ 10761, 10756 ]

2

[]

0

[ "3gmg" ]

1

[ "PUB00011928" ]

[ "2556375" ]

[ "Nucleotide sequence and insertional inactivation of a Bacillus subtilis gene that affects cell division, sporulation, and temperature sensitivity." ]

[ 1989 ]

1

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 10668, 1, 100 ]

3

[]

0

true

Family

Protein of unknown function DUF881

DUF881

6

IPR010274

10,274

Orthopoxvirus A36R

Orthopox_A36R

Family

94

false

This entry represents A36R from Vaccinia virus, also called Protein OPG164, and similar proteins predominantly found in orthopoxvirus. A36R is involved in the intracellular transport and egress of virions to the host cell surface with help of protein OPG056 [ ]. It also participates in the formation of actin tails at t...

[]

0

[ "PFAM" ]

[ "PF05950" ]

[ "Orthopox_A36R" ]

[ 94 ]

1

[]

0

[]

0

[ "PUB00011929", "PUB00103665", "PUB00103666", "PUB00103667", "PUB00103668" ]

[ "11017799", "19052096", "28631604", "27670116", "11470826" ]

[ "Identification and analysis of vaccinia virus palmitylproteins.", "Vaccinia virus protein F12 associates with intracellular enveloped virions through an interaction with A36.", "Vaccinia virus egress mediated by virus protein A36 is reliant on the F12 protein.", "NPF motifs in the vaccinia virus protein A36 ...

[ 2000, 2009, 2017, 2016, 2001 ]

5

[]

0

null

[ "Chordopoxvirinae" ]

[ 94 ]

1

[]

0

true

Family

Orthopoxvirus A36R

Orthopox_A36R

8

IPR010275

10,275

Peptidoglycan L,D-endopeptidase MepK

MepK

Family

5,934

false

This entry (previously DUF882) represents MepK and related proteins in bacteria. Some MepK proteins contain the TAT conserved site ( ). These proteins contain a similar fold to the zinc-binding motif in bacterial D-alanyl-D-alanine carboxypeptidases (DD-peptidases). Peptidoglycan L,D-endopeptidase MepK cleaves meso-dia...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05951", "PTHR37425" ]

[ "Peptidase_M15_2", "" ]

[ 5376, 5808 ]

2

[]

0

[]

0

[ "PUB00160786" ]

[ "30940749" ]

[ "Peptidoglycan hydrolase of an unusual cross-link cleavage specificity contributes to bacterial cell wall synthesis." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5869, 6, 13, 46 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Peptidoglycan L,D-endopeptidase MepK

MepK

9

IPR010276

10,276

Allatostatin

Family

257

false

This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata [ ].

[ "GO:0005184" ]

[ "neuropeptide hormone activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05953" ]

[ "Allatostatin" ]

[ 257 ]

1

[]

0

[]

0

[ "PUB00011931" ]

[ "10098619" ]

[ "The molecular evolution of the allatostatin precursor in cockroaches." ]

[ 1999 ]

1

[]

0

null

[ "Arthropoda", "Iodobacter fluviatilis" ]

[ 256, 1 ]

2

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Family

Allatostatin

3

IPR010278

10,278

Varicellovirus Gp2, glycoprotein

Varicellovirus_Gp2_glycop

Family

145

false

This entry consists of a number of glycoprotein Gp2 sequences mainly found from equine herpesviruses [ ].

[ "GO:0016032", "GO:0016020" ]

[ "viral process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05955" ]

[ "Herpes_gp2" ]

[ 145 ]

1

[]

0

[]

0

[ "PUB00019678" ]

[ "11958459" ]

[ "The C-terminal regions of the envelope glycoprotein gp2 of equine herpesviruses 1 and 4 are antigenically distinct." ]

[ 2002 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 145 ]

1

[]

0

true

Family

Varicellovirus Gp2, glycoprotein

Varicellovirus_Gp2_glycop

7

IPR010279

10,279

Inner membrane protein YqjD/ElaB

YqjD/ElaB

Family

7,929

false

This family consists of several bacterial proteins and includes the Escherichia coli genes for ElaB, YgaM and YqjD. YqjD is an inner membrane and ribosome binding protein expressed during the stationary growth phase. It is possible that YqjD inactivates ribosomes by localizing a part of the ribosome to the membrane dur...

[ "GO:0043022" ]

[ "ribosome binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR35893" ]

[ "" ]

[ 7929 ]

1

[]

0

[]

0

[ "PUB00086977", "PUB00086978" ]

[ "22661687", "28242719" ]

[ "YqjD is an inner membrane protein associated with stationary-phase ribosomes in Escherichia coli.", "Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli." ]

[ 2012, 2017 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanocalculus taiwanensis", "unclassified sequences" ]

[ 7890, 11, 1, 27 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Inner membrane protein YqjD/ElaB

YqjD/ElaB

9

IPR010280

10,280

(Uracil-5)-methyltransferase family

U5_MeTrfase_fam

Family

47,026

false

This family consists of (uracil-5-)-methyltransferases from bacteria, archaea and eukaryotes. They are class I-like SAM-binding methyltransferases. Methyltransferases (MTs) (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-me...

[ "GO:0008173", "GO:0006396" ]

[ "RNA methyltransferase activity", "RNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE", "PANTHER" ]

[ "PF05958", "PS51687", "PTHR11061" ]

[ "tRNA_U5-meth_tr", "SAM_MT_RNA_M5U", "" ]

[ 43333, 46598, 36819 ]

3

[ "EC", "PROSITEDOC" ]

[ "2.1.1", "PDOC00945" ]

[ "EC:2.1.1", "PROSITEDOC:PDOC00945" ]

2

[ "1uwv", "2bh2", "2jjq", "2vs1", "3bt7", "5xj1", "5xj2", "5zq0", "5zq1", "5zq8", "5zth", "8z62" ]

12

[ "PUB00054125", "PUB00057957", "PUB00057958" ]

[ "12826405", "16225687", "21858014" ]

[ "Many paths to methyltransfer: a chronicle of convergence.", "Natural history of S-adenosylmethionine-binding proteins.", "Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome." ]

[ 2003, 2005, 2011 ]

3

[]

[ "IPR001566", "IPR011825", "IPR011869", "IPR025795", "IPR045850" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 99, 38108, 8120, 60, 639 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 3, 3, 3, 3, 5, 8, 1, 9, 5, 1, 1, 44 ]

13

true

Family

(Uracil-5)-methyltransferase family

U5_MeTrfase_fam

1

IPR010281

10,281

Protein of unknown function DUF885

DUF885

Family

19,223

false

This family consists of hypothetical bacterial proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05960", "PTHR33361" ]

[ "DUF885", "" ]

[ 19161, 18780 ]

2

[]

0

[ "3iuk", "3o0y", "3u24" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 11, 17365, 1507, 2, 338 ]

5

[]

0

true

Family

Protein of unknown function DUF885

DUF885

1

IPR010282

10,282

Uncharacterised protein family HutD/Ves

Uncharacterised_HutD/Ves

Family

6,268

false

This entry contains proteins of unknown function, which include HutD from Pseudomonas fluorescens and Ves from Escherichia coli K12. HutD from P. fluorescens is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterised repressor protein HutC. Genetic analysis using transcr...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05962", "PTHR37943" ]

[ "HutD", "" ]

[ 6268, 6036 ]

2

[]

0

[ "1yll", "5fcc", "5v00" ]

3

[ "PUB00044765" ]

[ "17717196" ]

[ "Genetic analysis of the histidine utilization (hut) genes in Pseudomonas fluorescens SBW25." ]

[ 2007 ]

1

[]

[ "IPR023482" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6082, 146, 40 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family HutD/Ves

Uncharacterised_HutD/Ves

1

IPR010284

10,284

Photosystem II reaction center protein Ycf12

PSII_Ycf12_core-subunit

Family

1,748

false

This family represents Ycf12, also known as Photosystem II reaction center protein Psb30, a core subunit of photosystem II. Its function is unknown [ ]. Members of this entry are predominantly found in cyanobacteria and plants.

[ "GO:0015979", "GO:0009523", "GO:0016020" ]

[ "photosynthesis", "photosystem II", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "HAMAP", "PFAM" ]

[ "MF_01329", "PF05969" ]

[ "PSII_Psb30_Ycf12", "PSII_Ycf12" ]

[ 1613, 1748 ]

2

[]

0

[ "3a0b", "3a0h", "3kzi", "3wu2", "4fby", "4il6", "4ixq", "4ixr", "4pbu", "4pj0", "4rvy", "4tnh", "4tni", "4tnj", "4tnk", "4ub6", "4ub8", "4v62", "4v82", "4yuu", "5b5e", "5b66", "5e79", "5e7c", "5gth", "5gti", "5h2f", "5kaf", "5kai", "5mx2", "5tis", "5v2c"...

144

[ "PUB00053877" ]

[ "17935689" ]

[ "Ycf12 is a core subunit in the photosystem II complex." ]

[ 2007 ]

1

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 324, 1424 ]

2

[]

0

true

Family

Photosystem II reaction center protein Ycf12

PSII_Ycf12_core-subunit

7

IPR010285

10,285

DNA helicase Pif1-like, DEAD-box helicase domain

DNA_helicase_pif1-like_DEAD

Domain

34,191

false

This entry represents the DEAD-box helicase domain, which includes the ATP-binding region, of a group of DNA helicases, including Pif1 and Rrm3 from budding yeasts and Pfh1 from fusion yeast. This entry also includes Pif1 like proteins from prokaryotes and eukaryotes including plants. Pif1 is a DNA helicase conserved f...

[ "GO:0003678", "GO:0000723", "GO:0006281" ]

[ "DNA helicase activity", "telomere maintenance", "DNA repair" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF05970" ]

[ "PIF1" ]

[ 34191 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.3", "R-HSA-171319", "R-MMU-171319", "R-RNO-171319" ]

[ "EC:5.6.2.3", "REACTOME:R-HSA-171319", "REACTOME:R-MMU-171319", "REACTOME:R-RNO-171319" ]

4

[ "5fhd", "5fhe", "5fhf", "5fhg", "5fhh", "5ftb", "5ftc", "5ftd", "5fte", "5ftf", "5o6b", "5o6d", "5o6e", "6hph", "6hpq", "6hpt", "6hpu", "6l3g", "6s3e", "6s3h", "6s3i", "6s3m", "6s3n", "6s3o", "6s3p", "6xzt", "7ada", "7bil", "7lcc", "7oar", "7otj", "8bns"...

37

[ "PUB00053693", "PUB00053694", "PUB00066823", "PUB00066824", "PUB00069569", "PUB00069570" ]

[ "17172855", "16522649", "10926538", "10693764", "12058079", "18725402" ]

[ "Human PIF helicase is cell cycle regulated and associates with telomerase.", "The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity.", "Pif1p helicase, a catalytic inhibitor of telomerase in yeast.", "The Saccharomyces Pif1p DNA helicase and the highly related Rrm...

[ 2006, 2006, 2000, 2000, 2002, 2008 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4, 4680, 29033, 226, 248 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 25, 6, 33, 1, 2, 3, 3, 84, 2, 2, 1, 639 ]

12

true

Domain

DNA helicase Pif1-like, DEAD-box helicase domain

DNA_helicase_pif1-like_DEAD

6

IPR010286

10,286

METTL16/RlmF family

METTL16/RlmF

Family

9,789

false

This family includes ribosomal RNA large subunit methyltransferase F (RlmF), and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localisation [ ]. Another functional stu...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05971", "PTHR13393" ]

[ "Methyltransf_10", "" ]

[ 9753, 9649 ]

2

[ "EC", "EC" ]

[ "2.1.1", "2.1.1.181" ]

[ "EC:2.1.1", "EC:2.1.1.181" ]

2

[ "2h00", "3evz", "6b91", "6b92", "6du4", "6du5", "6gfk", "6gfn", "6gt5", "6m1u", "8gu3", "8pb3", "8pb4", "8pb5", "8pb6", "8pb7", "8pb8", "8qxq", "8zie", "8zig", "8zih", "8zii", "8zim", "8zio", "9fmh", "9fmi", "9fmj", "9fmk", "9gfs", "9gr6", "9gr7", "9u47"...

33

[ "PUB00052324", "PUB00085149", "PUB00086421", "PUB00086873" ]

[ "18021804", "27872311", "28525753", "28763571" ]

[ "The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel.", "Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.", "The U6 snRNA...

[ 2008, 2016, 2017, 2017 ]

4

[]

[ "IPR016909", "IPR017182" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 85, 4829, 4848, 27 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 2, 2, 2, 1, 6, 4, 1, 3, 4, 1, 9 ]

12

true

Family

METTL16/RlmF family

METTL16/RlmF

7

IPR010287

10,287

Protein of unknown function DUF892, YciF-like

DUF892_YciF-like

Family

9,706

false

This protein family is found in bacteria, including Protein YciF from Escherichia coli. This protein is produced by bacteria in response to stress conditions. It adopts a dimeric configuration in which each monomer shows five α-helices. Its function is still unknown [ ].

[]

0

[ "PFAM" ]

[ "PF05974" ]

[ "DUF892" ]

[ 9706 ]

1

[]

0

[ "2gs4", "2gyq", "3hiu", "3ogh", "4eru", "7tmv" ]

6

[ "PUB00041161" ]

[ "17001035" ]

[ "The crystal structure of the E. coli stress protein YciF." ]

[ 2006 ]

1

[]

[ "IPR047114" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 302, 9358, 16, 30 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF892, YciF-like

DUF892_YciF-like

2

IPR010288

10,288

Bacterial ABC transporter EcsB

EcsB_ABC

Family

4,434

false

The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions [ ]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [ , ]. More than 50 subfamil...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05975", "PIRSF037259" ]

[ "EcsB", "EcsB_ABC" ]

[ 4434, 3585 ]

2

[]

0

[]

0

[ "PUB00011939", "PUB00014769", "PUB00017894", "PUB00043654" ]

[ "8581172", "9873074", "11421269", "11421270" ]

[ "Molecular analysis of an operon in Bacillus subtilis encoding a novel ABC transporter with a role in exoprotein production, sporulation and competence.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physi...

[ 1996, 1999, 2001, 2001 ]

4

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 4425, 1, 8 ]

3

[]

0

true

Family

Bacterial ABC transporter EcsB

EcsB_ABC

5

IPR010290

10,290

Transmembrane secretion effector

TM_effector

Family

38,303

false

This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin [ ], and a protein involved in antibiotic resistance [ ].

[]

0

[ "PFAM" ]

[ "PF05977" ]

[ "MFS_3" ]

[ 38303 ]

1

[ "REACTOME" ]

[ "R-HSA-9638334" ]

[ "REACTOME:R-HSA-9638334" ]

1

[]

0

[ "PUB00053441", "PUB00060970" ]

[ "12068807", "15336408" ]

[ "Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter.", "The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis." ]

[ 2002, 2004 ]

2

[]

[ "IPR023722" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 97, 37223, 77, 906 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 1, 1 ]

2

true

Family

Transmembrane secretion effector

TM_effector

8

IPR010291

10,291

Ion channel regulatory protein, UNC-93

Ion_channel_UNC-93

Family

13,540

false

This family represents UNC-93 from Caenorhabditis elegans, protein unc-93 homologue A (UNC93A) and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) from mammals, and similar eukaryotic proteins. UNC-93 colocalises with SUP-10 and SUP-9 within muscle cells....

[]

0

[ "PFAM" ]

[ "PF05978" ]

[ "UNC-93" ]

[ 13540 ]

1

[]

0

[]

0

[ "PUB00053696", "PUB00097045", "PUB00097046", "PUB00101170" ]

[ "14534247", "27272503", "27458005", "23213353" ]

[ "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.", "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis.", "Inhibiting TLR9 and other UNC...

[ 2003, 2016, 2016, 2012 ]

4

[]

[ "IPR044771" ]

0

1

0

[ "Bacteria", "Eukaryota", "Mimiviridae" ]

[ 7, 13531, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 9, 26, 12, 6, 10, 8, 1, 12, 8, 1, 7 ]

11

true

Family

Ion channel regulatory protein, UNC-93

Ion_channel_UNC-93

8

IPR010292

10,292

Uncharacterised protein family CreA

Uncharacterised_CreA

Family

5,703

false

This family consists of several bacterial CreA proteins, the function of which is unknown.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05981", "PIRSF003174", "PTHR37952" ]

[ "CreA", "CreA", "" ]

[ 5703, 5242, 5685 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Straboviridae", "metagenomes" ]

[ 5516, 160, 4, 23 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family CreA

Uncharacterised_CreA

1

IPR010293

10,293

Na+-dependent bicarbonate transporter superfamily

Sbt_1

Family

3,162

false

This is a family of bacterial proteins that are likely to be part of the Na(+)-dependent bicarbonate transporter (sbt) family. Members carry 10TMS in a 5+5 duplicated structure. The loop between helices 5 and 6 in Synechocystis PCC6803 is likely to be the location for regulatory mechanisms governing the activation of t...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05982", "PTHR40400" ]

[ "Sbt_1", "" ]

[ 3162, 3149 ]

2

[]

0

[ "7cye", "7cyf", "7egk", "7egl" ]

4

[ "PUB00075354" ]

[ "21688970" ]

[ "Membrane topology of the cyanobacterial bicarbonate transporter, SbtA, and identification of potential regulatory loops." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrososphaerota", "ecological metagenomes" ]

[ 3051, 6, 29, 76 ]

4

[]

0

true

Family

Na+-dependent bicarbonate transporter superfamily

Sbt_1

3

IPR010294

10,294

ADAMTS/ADAMTS-like, Spacer 1

ADAMTS_spacer1

Domain

29,367

false

This entry represents the Spacer-1 domain found in ADAM-TS and ADAM-TS-like proteins. Proteolysis of the extracellular matrix plays a critical role in establishing tissue architecture during development and in tissue degradation in diseases such as cancer, arthritis, Alzheimer's disease and a variety of inflammatory co...

[]

0

[ "PFAM" ]

[ "PF05986" ]

[ "ADAMTS_spacer1" ]

[ 29367 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24", "R-BTA-1650814", "R-BTA-5173214", "R-CEL-5173214", "R-HSA-1474228", "R-HSA-1650814", "R-HSA-5083635", "R-HSA-5173214", "R-HSA-75892", "R-HSA-9845619", "R-HSA-9845621", "R-MMU-1474228", "R-MMU-1650814", "R-MMU-5173214", "R-MMU-75892", "R-RNO-1474228", "R-RNO-5173214" ]

[ "EC:3.4.24", "REACTOME:R-BTA-1650814", "REACTOME:R-BTA-5173214", "REACTOME:R-CEL-5173214", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-HSA-75892", "REACTOME:R-HSA-9845619", "REACTOME:R-HSA-9845621", "REACTOME:R-MMU-1474228...

17

[ "3ghm", "3ghn", "3vn4", "6qig" ]

4

[ "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017286", "PUB00017294", "PUB00085073", "PUB00090139", "PUB00090140", "PUB00098761", "PUB00098762", "PUB00098764", "PUB00098765" ]

[ "8995297", "10356395", "10464288", "9390552", "10417273", "11076767", "29885460", "11805097", "30905657", "17265492", "32150898", "34268335" ]

[ "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.", "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new fam...

[ 1997, 1999, 1999, 1997, 1999, 2000, 2018, 2002, 2019, 2007, 2020, 2021 ]

12

[]

0

null

[ "Eukaryota" ]

[ 29367 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 85, 11, 64, 66, 68 ]

6

true

Domain

ADAMTS/ADAMTS-like, Spacer 1

ADAMTS_spacer1

5

IPR010295

10,295

Protein of unknown function DUF898

DUF898

Family

3,911

false

This family consists of several bacterial proteins of unknown function. Some of the family, including YjgN, are putative transmembrane proteins. These proteins have a βααβα hairpin structure that is repeated.

[]

0

[ "PFAM" ]

[ "PF05987" ]

[ "DUF898" ]

[ 3911 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3874, 6, 31 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF898

DUF898

9

IPR010296

10,296

Protein of unknown function DUF899, thioredoxin-like

DUF899_thioredox

Family

8,307

false

This family consists of uncharacterised bacterial proteins of unknown function which are thioredoxin-like.

[]

0

[ "PFAM" ]

[ "PF05988" ]

[ "DUF899" ]

[ 8307 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 8, 7939, 349, 11 ]

4

[]

0

true

Family

Protein of unknown function DUF899, thioredoxin-like

DUF899_thioredox

4

IPR010297

10,297

Protein of unknown function DUF900, hydrolase-like

DUF900_hydrolase

Family

5,313

false

This domain is associated with proteins of unknown function, which are hydrolase-like.

[]

0

[ "PFAM" ]

[ "PF05990" ]

[ "DUF900" ]

[ 5313 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014586" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Fadolivirus FV1/VV64", "unclassified sequences" ]

[ 45, 4662, 568, 1, 37 ]

5

[]

0

true

Family

Protein of unknown function DUF900, hydrolase-like

DUF900_hydrolase

7

IPR010298

10,298

Ribosome-associated endoribonuclease 1

Rae1

Family

8,456

false

This entry represents Ribosome-associated endoribonuclease 1 (Rae1) also known as YacP. Rae1 associates with the ribosome and cleaves between specific codons of mRNAs in a translation- and reading frame-dependent manner [ , ]. It cleaves the yrzI operon mRNA within a short open reading frame called S1025 which encodes ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05991", "PTHR34547" ]

[ "NYN_YacP", "" ]

[ 8425, 6929 ]

2

[]

0

[ "5mq8", "5mq9" ]

2

[ "PUB00056584", "PUB00100990", "PUB00100991", "PUB00163240" ]

[ "17114934", "28363943", "29557713", "37142436" ]

[ "The NYN domains: novel predicted RNAses with a PIN domain-like fold.", "Rae1/YacP, a new endoribonuclease involved in ribosome-dependent mRNA decay in Bacillus subtilis.", "Distribution of the ribosome associated endonuclease Rae1 and the potential role of conserved amino acids in codon recognition.", ...

[ 2006, 2017, 2018, 2023 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7453, 919, 84 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 5, 8 ]

3

true

Family

Ribosome-associated endoribonuclease 1

Rae1

2

IPR010300

10,300

Cysteine dioxygenase type I

CDO_1

Family

11,590

false

Cysteine dioxygenase (CDO) plays an important role in the homeostatic regulation of steady-state cysteine levels and provides important oxidized metabolites of cysteine such as sulfate and taurine. It converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate production [ ]. This entry also i...

[ "GO:0005506", "GO:0016702" ]

[ "iron ion binding", "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05995", "PTHR12918" ]

[ "CDO_I", "" ]

[ 11189, 10860 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.20", "PWY-5331", "R-CEL-1614558", "R-HSA-1614558", "R-MMU-1614558", "R-RNO-1614558" ]

[ "EC:1.13.11.20", "METACYC:PWY-5331", "REACTOME:R-CEL-1614558", "REACTOME:R-HSA-1614558", "REACTOME:R-MMU-1614558", "REACTOME:R-RNO-1614558" ]

6

[ "2atf", "2b5h", "2gh2", "2ic1", "2q4s", "3eln", "3eqe", "3uss", "4ieo", "4iep", "4ieq", "4ier", "4ies", "4iet", "4ieu", "4iev", "4iew", "4iex", "4iey", "4iez", "4jtn", "4jto", "4kwj", "4kwk", "4kwl", "4pix", "4piy", "4piz", "4pjy", "4qm8", "4qm9", "4qma"...

90

[ "PUB00078862", "PUB00078863" ]

[ "26272617", "16855246" ]

[ "The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase.", "Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria." ]

[ 2015, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Megaviricetes", "Methanobacteriati", "metagenomes" ]

[ 7622, 3870, 15, 23, 60 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 2, 2, 1, 5, 1, 9 ]

7

true

Family

Cysteine dioxygenase type I

CDO_1

9

IPR010302

10,302

UL27-like protein, herpesvirus

UL27-like_protein_herpesevirus

Family

182

false

This entry represents a family of herpesvirus proteins that includes UL27, U5 and U7. UL27 promotes a cell cycle arrest in G0/G1 by inducing the proteasomal degradation of host histone acetyltransferase KAT5/Tip60 [ ].

[]

0

[ "PFAM" ]

[ "PF05999" ]

[ "Herpes_U5" ]

[ 182 ]

1

[ "REACTOME" ]

[ "R-HSA-9609690" ]

[ "REACTOME:R-HSA-9609690" ]

1

[ "7zn7", "7znn" ]

2

[ "PUB00151889" ]

[ "21320693" ]

[ "Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest." ]

[ 2011 ]

1

[]

0

null

[ "Herpesvirales", "Homo sapiens" ]

[ 181, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

UL27-like protein, herpesvirus

UL27-like_protein_herpesevirus

5

IPR010303

10,303

CREB-binding protein/p300, atypical RING domain

RING_CBP-p300

Domain

5,310

false

CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous...

[]

0

[ "PFAM", "CDD" ]

[ "PF06001", "cd15802" ]

[ "RING_CBP-p300", "RING_CBP-p300" ]

[ 5162, 5092 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.3.1.-", "2.3.1.48", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710"...

[ "EC:2.3.1.-", "EC:2.3.1.48", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", ...

350

[ "4bhw", "4n3w", "4n4f", "5i8b", "5i8g", "5lkt", "5lku", "5lkx", "5lkz", "5u7g", "5xzc", "6alb", "6gyr", "6k4n", "7ss8", "7ssk", "7vhy", "7vhz", "7vi0", "7w9v", "8cmz", "8cn0", "8cna", "8cnb", "8cnd", "8gzc", "8hag", "8hah", "8hai", "8haj", "8hak", "8hal"...

35

[ "PUB00074827" ]

[ "23934153" ]

[ "Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation." ]

[ 2013 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5310 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 1, 62, 4, 7, 7, 9, 2 ]

7

true

Domain

CREB-binding protein/p300, atypical RING domain

RING_CBP-p300

1

IPR010304

10,304

Survival motor neuron, Tudor domain

SMN_Tudor

Domain

4,525

false

This entry represents the Tudor domain of eukaryotic survival motor neuron (SMN) and survival of motor neuron-related-splicing factor 30 (SPF30) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) tha...

[ "GO:0003723", "GO:0006397", "GO:0005634", "GO:0005737" ]

[ "RNA binding", "mRNA processing", "nucleus", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06003" ]

[ "SMN_Tudor" ]

[ 4525 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-191859", "R-DRE-72163", "R-HSA-191859", "R-HSA-72163", "R-HSA-9754678", "R-MMU-191859", "R-MMU-72163", "R-RNO-191859", "R-RNO-72163", "R-XTR-72163" ]

[ "REACTOME:R-BTA-191859", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-191859", "REACTOME:R-RNO-72163", "REACTOME:R-XTR-72163" ]

10

[ "1g5v", "1mhn", "4a4e", "4a4f", "4a4g", "4a4h", "4qq6", "4v98", "7w2p", "7w30", "8poi" ]

11

[ "PUB00057060", "PUB00061133", "PUB00072203", "PUB00099986" ]

[ "22101937", "22607171", "18984161", "23022347" ]

[ "Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.", "Solution structure of the core SMN-Gemin2 complex.", "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.", "The survival motor neuron protein forms soluble glycine ...

[ 2011, 2012, 2008, 2012 ]

4

[]

[ "IPR047298" ]

0

1

0

[ "Eukaryota" ]

[ 4525 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 4, 4, 12, 9, 3, 11, 8 ]

8

true

Domain

Survival motor neuron, Tudor domain

SMN_Tudor

8

IPR010305

10,305

Lipoprotein YgdI/YgdR-like

YgdI/YgdR-like

Family

5,124

false

This family consists of several small bacterial lipoproteins, including YgdI and YgdR from E. coli. The function of this family is unknown.

[]

0

[ "NCBIFAM", "PANTHER" ]

[ "NF033216", "PTHR37011" ]

[ "lipo_YgdI_YgdR", "" ]

[ 5124, 5104 ]

2

[]

0

[ "2jn0", "2k57", "2ra2", "2rb6", "2rd1", "3bdu", "3fif", "5cai" ]

8

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 5113, 11 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Lipoprotein YgdI/YgdR-like

YgdI/YgdR-like

7

IPR010306

10,306

Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase

PhnJ

Family

3,934

false

The cleavage of the C-P bond in PRPn to form a-D-ribose-1,2-cyclic-phosphate-5-phosphate (PRcP) is assumed to involve a radical mechanism and PhnJ is a protein that, belonging to the Radical SAM superfamily can perform such a reaction. This enzyme appears to function through the formation of a glycyl radical by the 5'-...

[ "GO:0016829", "GO:0051539", "GO:0019700" ]

[ "lyase activity", "4 iron, 4 sulfur cluster binding", "organic phosphonate catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF", "SFLD" ]

[ "PF06007", "PIRSF011468", "SFLDF00379" ]

[ "PhnJ", "PhnJ", "Phosphonate_metabolism_(PhnJ)" ]

[ 3934, 3637, 3631 ]

3

[ "GP", "GP", "GP", "GP" ]

[ "GenProp0232", "GenProp1165", "GenProp1381", "GenProp1630" ]

[ "GP:GenProp0232", "GP:GenProp1165", "GP:GenProp1381", "GP:GenProp1630" ]

4

[ "4xb6", "7z15", "7z16", "7z17", "7z18", "7z19" ]

6

[ "PUB00079189", "PUB00081921" ]

[ "22089136", "23615610" ]

[ "Intermediates in the transformation of phosphonates to phosphate by bacteria.", "The catalytic mechanism for aerobic formation of methane by bacteria." ]

[ 2011, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 3880, 5, 34, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase

PhnJ

7

IPR010307

10,307

Laminin domain II

Laminin_dom_II

Domain

5,559

false

It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [ ].

[ "GO:0007155" ]

[ "cell adhesion" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06009" ]

[ "Laminin_II" ]

[ 5559 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1474228", "R-HSA-2022090", "R-HSA-2214320", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-373760", "R-HSA-446107", "R-HSA-6785807", "R-HSA-8874081", "R-HSA-9619665", "R-HSA-9638630", "R-HSA-9913351", "R-HSA-9925563", "R-MMU-3000157", "R-MMU-8874081", "R-MMU-9913351...

[ "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-2214320", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-373760", "REACTOME:R-HSA-446107", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8874081", "REACTOME:R-HSA-9619665", "REACTOME:...

17

[ "5mc9", "5xau", "7cec" ]

3

[ "PUB00012222" ]

[ "3182802" ]

[ "Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains." ]

[ 1988 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)" ]

[ 2, 5556, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 18, 2, 19, 12, 20 ]

6

true

Domain

Laminin domain II

Laminin_dom_II

7

IPR010308

10,308

TRP, C-terminal

TRP_C

Domain

6,956

false

This entry represents the C-terminal domain of transient receptor potential channel-like proteins. The family includes several fungal flavin carrier proteins, which may be responsible for the transport of FAD into the endoplasmatic reticulum lumen, where it is required for oxidative protein folding [ ]. The family also...

[]

0

[ "PFAM" ]

[ "PF06011" ]

[ "TRP" ]

[ 6956 ]

1

[]

0

[]

0

[ "PUB00020495", "PUB00057860" ]

[ "15537393", "16717099" ]

[ "A microbial TRP-like polycystic-kidney-disease-related ion channel gene.", "A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Chryseobacterium arthrosphaerae", "Eukaryota", "Megaviridae environmental sample" ]

[ 1, 6954, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 4, 3 ]

3

true

Domain

TRP, C-terminal

TRP_C

9

IPR010309

10,309

E3 ubiquitin ligase, domain of unknown function DUF908

E3_Ub_ligase_DUF908

Domain

5,700

false

This is a domain of unknown function found at the N terminus of a family of E3 ubiquitin protein ligases, including yeast TOM1, many of which appear to play a role in mRNA transcription and processing. This domain is found in association with and immediately N-terminal to another domain of unknown function: .

[]

0

[ "PFAM" ]

[ "PF06012" ]

[ "DUF908" ]

[ 5700 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.26", "PWY-7511", "R-HSA-6798695", "R-HSA-983168", "R-MMU-6798695", "R-MMU-983168", "R-SCE-6798695", "R-SCE-983168", "R-SPO-6798695", "R-SPO-983168" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-6798695", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-6798695", "REACTOME:R-SPO-983168" ]

10

[ "7bii", "7jq9", "7mop", "7mwd", "7mwe", "7mwf", "7nh1", "7nh3", "9dns", "9dnt", "9egk", "9eld", "9mhp" ]

13

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5699, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 8, 33, 7, 7, 8, 1, 5, 6, 1, 1, 24 ]

12

true

Domain

E3 ubiquitin ligase, domain of unknown function DUF908

E3_Ub_ligase_DUF908

2

IPR010310

10,310

Type VII secretion system ESAT-6-like

T7SS_ESAT-6-like

Family

19,320

false

Members of this protein family include secretion targets for type main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. Members of this family usually are ~100 amino acids in length but occasionally have long C-terminal extension [ ]. The best characterised me...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06013", "TIGR03930" ]

[ "WXG100", "WXG100_ESAT6" ]

[ 19258, 11741 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0904", "GenProp0905", "R-HSA-9635644", "R-HSA-9636383", "R-HSA-9636667", "R-HSA-9637628" ]

[ "GP:GenProp0904", "GP:GenProp0905", "REACTOME:R-HSA-9635644", "REACTOME:R-HSA-9636383", "REACTOME:R-HSA-9636667", "REACTOME:R-HSA-9637628" ]

6

[ "1wa8", "2kg7", "2vrz", "2vs0", "3fav", "3gvm", "3gwk", "3h6p", "3o9o", "3ogi", "3q4h", "3zbh", "4gzr", "4i0x", "4iyh", "4iyi", "4j10", "4j11", "4j41", "4j42", "4j7j", "4j7k", "4lws", "6j19" ]

24

[ "PUB00018371", "PUB00060402" ]

[ "11973144", "18723613" ]

[ "The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?", "ESAT-6-like protein secretion in Bacillus anthracis." ]

[ 2002, 2008 ]

2

[]

[ "IPR009416" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]

[ 19226, 43, 50, 1 ]

4

[]

0

true

Family

Type VII secretion system ESAT-6-like

T7SS_ESAT-6-like

1

IPR010313

10,313

Glycine N-acyltransferase

Glycine_N-acyltransferase

Family

2,968

false

This entry represents glycine N-acyltransferase (also called aralkyl acyl-CoA:amino acid N-acyltransferase; ). Mitochondrial acyltransferases catalyse the transfer of an acyl group from acyl-CoA to the N terminus of glycine to produce N-acylglycine. These enzymes can conjugate a multitude of substrates to form a variet...

[ "GO:0047961", "GO:0005739" ]

[ "glycine N-acyltransferase activity", "mitochondrion" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR15298" ]

[ "" ]

[ 2968 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1.13", "R-HSA-177128", "R-HSA-177135", "R-HSA-9749641", "R-MMU-177128", "R-MMU-177135", "R-MMU-9749641", "R-RNO-177128", "R-RNO-177135", "R-RNO-9749641" ]

[ "EC:2.3.1.13", "REACTOME:R-HSA-177128", "REACTOME:R-HSA-177135", "REACTOME:R-HSA-9749641", "REACTOME:R-MMU-177128", "REACTOME:R-MMU-177135", "REACTOME:R-MMU-9749641", "REACTOME:R-RNO-177128", "REACTOME:R-RNO-177135", "REACTOME:R-RNO-9749641" ]

10

[ "7pk0", "7pk1", "7pk2" ]

3

[ "PUB00036032", "PUB00036033" ]

[ "10630424", "8660675" ]

[ "The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase.", "Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase." ]

[ 2000, 1996 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 13, 2953, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 14, 7, 9 ]

5

true

Family

Glycine N-acyltransferase

Glycine_N-acyltransferase

6

IPR010315

10,315

Protein of unknown function DUF915, hydrolase-like

DUF915_hydro-like

Family

4,131

false

This family consists of bacterial hydrolase-like proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06028" ]

[ "DUF915" ]

[ 4131 ]

1

[]

0

[ "3ds8", "3fle", "3lp5" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Fadolivirus FV1/VV64", "metagenomes" ]

[ 4100, 20, 1, 10 ]

4

[]

0

true

Family

Protein of unknown function DUF915, hydrolase-like

DUF915_hydro-like

9

IPR010316

10,316

DNA-3-methyladenine glycosylase AlkA, N-terminal

AlkA_N

Domain

9,758

false

AlkA (DNA-3-methyladenine glycosylase II) is a base excision repair glycosylase from Escherichia coli. It removes a variety of alkylated bases from DNA, primarily by removing alkylation damage from duplex and single stranded DNA. AlkA is similar in fold and active site location to the bifunctional glycosylase/lyase end...

[]

0

[ "PFAM", "SMART" ]

[ "PF06029", "SM01009" ]

[ "AlkA_N", "AlkA_N" ]

[ 9383, 9685 ]

2

[ "EC" ]

[ "3.2.2.21" ]

[ "EC:3.2.2.21" ]

1

[ "1diz", "1mpg", "1pvs", "3cvs", "3cvt", "3cw7", "3cwa", "3cws", "3cwt", "3cwu", "3d4v", "3ogd", "3oh6", "3oh9" ]

14

[ "PUB00000939", "PUB00029997" ]

[ "8706136", "12009927" ]

[ "Structural basis for the excision repair of alkylation-damaged DNA.", "3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition." ]

[ 1996, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinales", "unclassified sequences" ]

[ 9688, 7, 5, 58 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA-3-methyladenine glycosylase AlkA, N-terminal

AlkA_N

9

IPR010317

10,317

WxL Interacting Protein, peptidoglycan binding domain

WxLIP_PGBD

Domain

3,613

false

This domain is found in WxL interacting proteins (WxLIP) which play a role in virulence and are widely distributed in firmicutes. The WxL proteins usually occur within a gene cluster that contains two WxL proteins and a WxL interacting protein composed of three domains: peptidoglycan binding domain (PGBD), host binding...

[]

0

[ "PFAM" ]

[ "PF06030" ]

[ "WxLIP_PGBD" ]

[ 3613 ]

1

[]

0

[]

0

[ "PUB00154331" ]

[ "37833244" ]

[ "DUF916 and DUF3324 in the WxL protein cluster bind to WxL and link bacterial and host surfaces." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "ecological metagenomes" ]

[ 3604, 3, 6 ]

3

[]

0

true

Domain

WxL Interacting Protein, peptidoglycan binding domain

WxLIP_PGBD

1

IPR010318

10,318

S-Me-THD, N-terminal domain

S-Me-THD_N

Domain

6,153

false

This entry represents a domain found N-terminal of S-methyl thiohydantoin desulfurase from Variovorax sp. (S-Me-THD), 3-(5-oxo-2-thioxoimidazolidin-4-yl)propionic acid desulfhydrase (ERTC) from Paenibacillus sp. and similar sequences mainly found in bacteria and fungi. S-Me-THD catalyses the hydrolysis of S-methyl-thio...

[]

0

[ "PFAM" ]

[ "PF06032" ]

[ "S-Me-THD_N" ]

[ 6153 ]

1

[]

0

[ "2o3i" ]

1

[ "PUB00155448", "PUB00163302" ]

[ "38389448", "33544568" ]

[ "Structure and Substrate Specificity of S-Methyl Thiourocanate Hydratase.", "In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism." ]

[ 2024, 2021 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 194, 3664, 2219, 76 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

S-Me-THD, N-terminal domain

S-Me-THD_N

7

IPR010319

10,319

Transglutaminase-like cysteine peptidase, predicted

Transglutaminase-like_Cys_pept

Family

6,817

false

Structural analysis predicts that this family of proteins are bacterial transglutaminase-like cysteine peptidases (BTLCPs) with an invariant Cys-His-Asp catalytic triad and an N-terminal signal sequence. They are predicted to possess the papain-like cysteine proteinase fold and catalyse post-translational protein modif...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06035", "PTHR39327" ]

[ "Peptidase_C93", "" ]

[ 6504, 6690 ]

2

[]

0

[ "4fgo", "4fgp", "4fgq", "4u65" ]

4

[ "PUB00015047" ]

[ "15288868" ]

[ "BTLCP proteins: a novel family of bacterial transglutaminase-like cysteine proteinases." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 253, 6463, 5, 12, 84 ]

5

[]

0

true

Family

Transglutaminase-like cysteine peptidase, predicted

Transglutaminase-like_Cys_pept

7

IPR010321

10,321

Protein of unknown function DUF922

DUF922

Family

2,848

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06037", "PIRSF010521" ]

[ "DUF922", "DUF922_bac" ]

[ 2848, 1155 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "ecological metagenomes" ]

[ 2798, 1, 33, 16 ]

4

[]

0

true

Family

Protein of unknown function DUF922

DUF922

3

IPR010323

10,323

Protein of unknown function DUF924

DUF924

Family

8,911

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06041" ]

[ "DUF924" ]

[ 8911 ]

1

[]

0

[ "2i6h" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6991, 1806, 11, 103 ]

4

[]

0

true

Family

Protein of unknown function DUF924

DUF924

1

IPR010324

10,324

Dam-replacing

DRP

Family

366

false

Dam-replacing protein (DRP) is a restriction endonuclease that is flanked by pseudo-transposable small repeat elements. The replacement of Dam-methylase by DRP allows phase variation through slippage-like mechanisms in several pathogenic isolates of Neisseria meningitidis [ ].

[]

0

[ "PFAM" ]

[ "PF06044" ]

[ "DpnI" ]

[ 366 ]

1

[]

0

[ "4esj", "4kyw" ]

2

[ "PUB00012233" ]

[ "11334887" ]

[ "Evolution and function of the neisserial dam-replacing gene." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Mimiviridae", "metagenomes" ]

[ 6, 347, 2, 11 ]

4

[]

0

true

Family

Dam-replacing

DRP

2

IPR010325

10,325

Rhamnogalacturonate lyase

Rhamnogal_lyase

Family

4,284

false

Rhamnogalacturonate lyase degrades the rhamnogalacturonan I (RG-I) backbone of pectin [ ]. This family contains mainly members from plants, but also contains the plant pathogen Erwinia chrysanthemi.

[]

0

[ "PFAM" ]

[ "PF06045" ]

[ "Rhamnogal_lyase" ]

[ 4284 ]

1

[]

0

[]

0

[ "PUB00012234" ]

[ "12591882" ]

[ "Rhamnogalacturonate lyase RhiE is secreted by the out system in Erwinia chrysanthemi." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 154, 4129, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 50, 16, 23 ]

3

true

Family

Rhamnogalacturonate lyase

Rhamnogal_lyase

2

IPR010326

10,326

Exocyst complex component EXOC3/Sec6

EXOC3/Sec6

Family

10,086

false

Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70. These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis-independent manner [...

[ "GO:0006887", "GO:0000145" ]

[ "exocytosis", "exocyst" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06046", "PTHR21292" ]

[ "Sec6", "" ]

[ 9623, 9925 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-264876", "R-BTA-5620916", "R-CEL-264876", "R-CEL-5620916", "R-DDI-264876", "R-DME-264876", "R-DME-5620916", "R-HSA-1445148", "R-HSA-264876", "R-HSA-5620916", "R-MMU-264876", "R-MMU-5620916", "R-RNO-264876", "R-RNO-5620916" ]

[ "REACTOME:R-BTA-264876", "REACTOME:R-BTA-5620916", "REACTOME:R-CEL-264876", "REACTOME:R-CEL-5620916", "REACTOME:R-DDI-264876", "REACTOME:R-DME-264876", "REACTOME:R-DME-5620916", "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-5620916", "REACTOME:R-MMU-264876", "REACTOME:R-MM...

14

[ "2fji", "5b86", "5yfp", "6vkl" ]

4

[ "PUB00012235" ]

[ "11854409" ]

[ "The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 10086 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 22, 1, 24, 15, 1, 5, 17, 1, 1, 26 ]

12

true

Family

Exocyst complex component EXOC3/Sec6

EXOC3/Sec6

1

IPR010327

10,327

FldB/FldC dehydratase alpha/beta subunit

FldB/FldC_alpha/beta

Family

6,537

false

This entry includes HgdA/B from Acidaminococcus fermentans, FldB/C from Clostridium sporogenes and BcrB/C from Thauera aromatica. Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase consists of two components: A (for activator or initiator) and D (for dehydratase). HgdA and B form a heterodimeric enzyme design...

[]

0

[ "PFAM" ]

[ "PF06050" ]

[ "HGD-D" ]

[ 6537 ]

1

[]

0

[ "3o3m", "3o3n", "3o3o", "6eno", "7yyl", "7yzm", "7yzq", "8s02", "8s1t", "8s2r" ]

10

[ "PUB00077140", "PUB00161736" ]

[ "11967068", "21366233" ]

[ "Molecular characterization of phenyllactate dehydratase and its initiator from Clostridium sporogenes.", "Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase." ]

[ 2002, 2011 ]

2

[]

[ "IPR011955", "IPR011958", "IPR017603", "IPR017604", "IPR047678" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctjdk2", "unclassified sequences" ]

[ 145, 6008, 2, 2, 380 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

FldB/FldC dehydratase alpha/beta subunit

FldB/FldC_alpha/beta

9

IPR010328

10,328

Protein of unknown function DUF928

DUF928

Family

1,686

false

This is a family of uncharacterised bacterial proteins. They contain a β-sheet connected to small α-helices. Some of them contain a ipid attachment site.

[]

0

[ "PFAM" ]

[ "PF06051" ]

[ "DUF928" ]

[ 1686 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1683, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF928

DUF928

3

IPR010329

10,329

3-hydroxyanthranilic acid dioxygenase

3hydroanth_dOase

Family

6,025

false

Members of this protein family, from both bacteria and eukaryotes, are the enzyme 3-hydroxyanthranilate 3,4-dioxygenase ( ). It is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [ ].The prokaryotic homologue is involved in the 2-nitrobenzoate degradation pathway ...

[ "GO:0000334", "GO:0005506" ]

[ "3-hydroxyanthranilate 3,4-dioxygenase activity", "iron ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00825", "PF06052", "PTHR15497", "TIGR03037", "cd06123" ]

[ "3_HAO", "3-HAO", "", "anthran_nbaC", "cupin_HAO" ]

[ 5407, 6000, 5984, 5478, 5811 ]

5

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.6", "GenProp1503", "PWY-5647", "PWY-5651", "PWY-6309", "PWY-6505", "R-CEL-71240", "R-DDI-71240", "R-DRE-71240", "R-HSA-71240", "R-MMU-71240", "R-RNO-71240", "R-SCE-71240", "R-XTR-71240" ]

[ "EC:1.13.11.6", "GP:GenProp1503", "METACYC:PWY-5647", "METACYC:PWY-5651", "METACYC:PWY-6309", "METACYC:PWY-6505", "REACTOME:R-CEL-71240", "REACTOME:R-DDI-71240", "REACTOME:R-DRE-71240", "REACTOME:R-HSA-71240", "REACTOME:R-MMU-71240", "REACTOME:R-RNO-71240", "REACTOME:R-SCE-71240", "REACTOM...

14

[ "1yfu", "1yfw", "1yfx", "1yfy", "1zvf", "2qnk", "3fe5", "4hsj", "4hsl", "4hvo", "4hvq", "4hvr", "4i3p", "4l2n", "4r52", "4wzc", "5tk5", "5tkq", "5v26", "5v27", "5v28", "6bvp", "6bvq", "6bvr", "6bvs", "6cd3", "6d60", "6d61", "6d62", "6vi5", "6vi6", "6vi7"...

37

[ "PUB00012238", "PUB00012239" ]

[ "9539135", "12620844" ]

[ "The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis.", "Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomon...

[ 1998, 2003 ]

2

[]

[ "IPR016700" ]

0

1

0

[ "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured marine group II/III euryarchaeote KM3_76_C12" ]

[ 2803, 3167, 54, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 5, 2, 4, 1, 10, 1 ]

7

true

Family

3-hydroxyanthranilic acid dioxygenase

3hydroanth_dOase

6

IPR010330

10,330

Competence protein CoiA, nuclease-like domain

CoiA_nuc

Domain

3,944

false

This entry represents a domain found in the Competence protein CoiA from Bacillus subtilis and related proteins. This domain has a detectable similarity to PD-(D/E)XK nuclease superfamily and is predicted to adopt a similar structure. CoiA falls within a competence-specific operon in Streptococcus. It is required for o...

[]

0

[ "PFAM" ]

[ "PF06054" ]

[ "CoiA_nuc" ]

[ 3944 ]

1

[]

0

[]

0

[ "PUB00052316", "PUB00081394" ]

[ "8901420", "17630974" ]

[ "Who's competent and when: regulation of natural genetic competence in bacteria.", "Multiple interactions among the competence proteins of Bacillus subtilis." ]

[ 1996, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "Viruses", "metagenomes" ]

[ 10, 3882, 1, 6, 45 ]

5

[]

0

true

Domain

Competence protein CoiA, nuclease-like domain

CoiA_nuc

3